Table S1. List of Viral Enriched KEGG Orthologs

Table S1. List of viral enriched KEGG orthologs.

Hyper Geometric P- number of hits KEGG Ortholog Name Definition GOS Scaffolds value in VirMic JCVI_SCAF_10966277 31713, JCVI_SCAF_10966273 85149, JCVI_SCAF_10966266 27396, 3-methyl-2-oxobutanoate JCVI_SCAF_10966268 K00606 panB hydroxymethyltransferase 1.00E-016 17 93752, [EC:2.1.2.11] JCVI_SCAF_10966272 84915, JCVI_SCAF_10966271 77339, JCVI_SCAF_10966271 77529, JCVI_SCAF_10966273 64882, JCVI_SCAF_10966270 K01185 E3.2.1.17 lysozyme [EC:3.2.1.17] 1.00E-016 15 18658, JCVI_SCAF_10966273 89241, JCVI_SCAF_10966269 79423, JCVI_SCAF_11016687 35076, JCVI_SCAF_10966269 enoyl-[acyl carrier protein] 68704, K02371 fabK 1.00E-016 14 reductase II [EC:1.3.1.-] JCVI_SCAF_10966277 51594, JCVI_SCAF_10966270 77249, JCVI_SCAF_10966271 62261, K03111 ssb single-strand DNA-binding JCVI_SCAF_10966275 1.00E-016 27 protein 10176, JCVI_SCAF_10966266 27396, JCVI_SCAF_10966269 23853, JCVI_SCAF_11016681 83919, JCVI_SCAF_10966272 31399, JCVI_SCAF_10966266 32408, JCVI_SCAF_10966275 22253, JCVI_SCAF_10966275 02316, JCVI_SCAF_10966280 36061, JCVI_SCAF_10966278 23561, JCVI_SCAF_10966273 85149, JCVI_SCAF_10966283 85900, JCVI_SCAF_10966282 01501, JCVI_SCAF_10966266 59356, JCVI_SCAF_10966268 93752, JCVI_SCAF_10966271 77339, JCVI_SCAF_10966275 04991, JCVI_SCAF_10966276 95455, JCVI_SCAF_10966281 11213, K03164 TOP2 DNA topoisomerase II JCVI_SCAF_10966268 1.00E-016 25 [EC:5.99.1.3] 53028, JCVI_SCAF_10966273 49372, JCVI_SCAF_10966268 70105, translation initiation factor JCVI_SCAF_10966273 K03257 EIF4A 1.00E-016 11 4A 48832, JCVI_SCAF_10966268 64678, JCVI_SCAF_10966283 10423, JCVI_SCAF_10966275 31280, thymidylate synthase JCVI_SCAF_10966270 K03465 E2.1.1.148, 1.00E-016 15 (FAD) [EC:2.1.1.148] 80753, JCVI_SCAF_10966281 67713, JCVI_SCAF_10966268 62564, JCVI_SCAF_10966269 11780, phage replication initiation JCVI_SCAF_10966273 K07467 rstA1 1.00E-016 8 protein 89014, ribonucleoside- JCVI_SCAF_10966268 K10807 RRM1 diphosphate reductase 1.00E-016 15 54395, subunit M1 [EC:1.17.4.1] JCVI_SCAF_10966271 38013, JCVI_SCAF_10966270 replication factor C 80753, K10755 RFC2_4 5.00E-015 7 subunit 2/4 JCVI_SCAF_10966269 11780, JCVI_SCAF_10966268 62564, formate dehydrogenase- JCVI_SCAF_10966273 K08350 fdnI 1.93E-014 5 N, gamma subunit 89014, JCVI_SCAF_10966269 07437, JCVI_SCAF_10966272 adenylate cyclase 89696, K01768 E4.6.1.1 1.43E-013 10 [EC:4.6.1.1] JCVI_SCAF_10966270 89045, JCVI_SCAF_10966269 15608, JCVI_SCAF_10966273 K02380 fdhE FdhE protein 2.17E-013 6 89014, JCVI_SCAF_10966268 54395, ribonucleoside- JCVI_SCAF_10966268 K00525 E1.17.4.1A, diphosphate reductase 7.06E-013 18 67376, alpha chain [EC:1.17.4.1] JCVI_SCAF_10966273 84817, JCVI_SCAF_11016682 91686, JCVI_SCAF_10966273 83283, JCVI_SCAF_10966271 68531, JCVI_SCAF_10966273 23705, JCVI_SCAF_10966269 87692, fructose-bisphosphate JCVI_SCAF_10966277 K01623 ALDO, aldolase, class I 7.83E-013 13 58744, [EC:4.1.2.13] JCVI_SCAF_10966270 57106, JCVI_SCAF_10966270 47369, JCVI_SCAF_10966277 05816, JCVI_SCAF_10966271 80231, JCVI_SCAF_10966269 94794, JCVI_SCAF_10966272 84174, JCVI_SCAF_10966269 replication factor C small 07808, K04801 rfcS 1.19E-012 7 subunit JCVI_SCAF_10966271 66494, JCVI_SCAF_10966268 52521, K04488 iscU, nitrogen fixation protein JCVI_SCAF_10966278 1.56E-012 9 NifU and related proteins 39980, JCVI_SCAF_10966268 54311, JCVI_SCAF_10966268 53996, JCVI_SCAF_10966271 60741, JCVI_SCAF_11016682 79682, JCVI_SCAF_10966269 45599, JCVI_SCAF_10966272 82967, JCVI_SCAF_10966272 96442, JCVI_SCAF_10966273 13587, JCVI_SCAF_10966276 GDPmannose 4, 6- 79763, K01711 E4.2.1.47, 5.45E-012 13 dehydratase [EC:4.2.1.47] JCVI_SCAF_10966275 56784, JCVI_SCAF_10966270 14936, JCVI_SCAF_10966268 48677, JCVI_SCAF_10966283 90190, JCVI_SCAF_10966271 81117, JCVI_SCAF_10966273 NAD(P)H-quinone 85003, K05575 ndhD oxidoreductase subunit 4 8.79E-012 9 JCVI_SCAF_10966271 [EC:1.6.5.3] 79179, JCVI_SCAF_10966271 56275, JCVI_SCAF_10966270 UDP-galactopyranose 23014, K01854 glf 4.91E-011 6 mutase [EC:5.4.99.9] JCVI_SCAF_10966269 07808, K03217 yidC, preprotein translocase JCVI_SCAF_10966273 1.02E-010 10 subunit YidC 56937, JCVI_SCAF_10966268 88333, JCVI_SCAF_10966270 12170, JCVI_SCAF_10966279 65504, JCVI_SCAF_10966269 56250, photosystem II P680 JCVI_SCAF_11016686 K02703 psbA 1.12E-010 7 reaction center D1 protein 99797, JCVI_SCAF_10966275 72272, JCVI_SCAF_10966270 16144, JCVI_SCAF_10966271 80827, phosphoserine JCVI_SCAF_10966273 K01079 serB, 1.66E-010 7 phosphatase [EC:3.1.3.3] 15158, JCVI_SCAF_10966268 UV DNA damage 54834, K13281 uvsE, 4.61E-010 6 endonuclease [EC:3.-.-.-] JCVI_SCAF_10966269 59094, JCVI_SCAF_10966274 86536, JCVI_SCAF_10966268 52842, JCVI_SCAF_10966270 peroxiredoxin (alkyl 32801, K03386 E1.11.1.15, hydroperoxide reductase 1.29E-009 7 JCVI_SCAF_10966280 subunit C) [EC:1.11.1.15] 32750, JCVI_SCAF_10966276 03677, JCVI_SCAF_10966273 98054, troponin T, fast skeletal JCVI_SCAF_10966268 K12046 TNNT3 1.43E-009 3 muscle 54834, acyl-CoA dehydrogenase JCVI_SCAF_10966268 K06445 fadE 1.14E-008 5 [EC:1.3.99.-] 54116, K02040 pstS phosphate transport JCVI_SCAF_10966269 7.14E-008 7 system substrate-binding 53943, JCVI_SCAF_10966275 13414, JCVI_SCAF_10966273 81361, JCVI_SCAF_10966269 38230, protein JCVI_SCAF_10966283 85461, JCVI_SCAF_10966269 85784, JCVI_SCAF_10966269 70597, JCVI_SCAF_10966273 17553, JCVI_SCAF_10966270 photosystem II P680 47510, K02706 psbD 1.94E-007 5 reaction center D2 protein JCVI_SCAF_10966271 45129, JCVI_SCAF_10966269 87982, fatty acid desaturase JCVI_SCAF_10966268 K12418 K12418 (delta-4 desaturase) 2.54E-007 2 54116, [EC:1.14.19.-] origin recognition complex JCVI_SCAF_10966272 K02604 ORC2 4.24E-007 2 subunit 2 55261, glutamyl-Q tRNA(Asp) JCVI_SCAF_10966273 K01894 gluQ 8.92E-007 4 synthetase [EC:6.1.1.-] 55747, mannose-6-phosphate JCVI_SCAF_10966269 K01809 E5.3.1.8, 2.72E-006 6 isomerase [EC:5.3.1.8] 07808, JCVI_SCAF_10966270 55207, orotate JCVI_SCAF_10966273 K00762 pyrE phosphoribosyltransferas 3.36E-006 6 75293, e [EC:2.4.2.10] JCVI_SCAF_10966270 55627, K00558 E2.1.1.37, DNA (cytosine-5-)- JCVI_SCAF_10966269 5.30E-006 6 methyltransferase 02801, [EC:2.1.1.37] JCVI_SCAF_10966276 84793, JCVI_SCAF_10966271 46939, JCVI_SCAF_10966272 82997, JCVI_SCAF_10966273 88037, JCVI_SCAF_11016683 08796, aminomethyltransferase JCVI_SCAF_10966270 K00605 gcvT, 6.78E-006 8 [EC:2.1.2.10] 55138, JCVI_SCAF_10966269 89824, JCVI_SCAF_10966270 50166, JCVI_SCAF_10966275 10176, JCVI_SCAF_10966283 85900, replicative DNA helicase JCVI_SCAF_10966280 K02314 dnaB 8.95E-006 8 [EC:3.6.4.12] 36061, JCVI_SCAF_10966269 23853, JCVI_SCAF_10966276 95455, DNA polymerase II small JCVI_SCAF_10966271 K02323 DPB2 1.86E-005 3 subunit [EC:2.7.7.7] 75513, 3-deoxy-manno- octulosonate JCVI_SCAF_10966270 K00979 kdsB cytidylyltransferase (CMP- 2.17E-005 5 98003, KDO synthetase) [EC:2.7.7.38] GDP-L-fucose synthase JCVI_SCAF_10966273 K02377 E1.1.1.271, 2.32E-005 5 [EC:1.1.1.271] 13587, JCVI_SCAF_10966268 nitronate monooxygenase 74170, K00459 E1.13.12.16 4.39E-005 4 [EC:1.13.12.16] JCVI_SCAF_10966273 28767, K05337 fer ferredoxin JCVI_SCAF_10966266 1.30E-004 3 56929, JCVI_SCAF_10966273 75096, JCVI_SCAF_10966280 00696, DnaJ homolog subfamily JCVI_SCAF_10966273 K09503 DNAJA2 1.57E-004 2 A member 2 48773, small subunit ribosomal JCVI_SCAF_10966266 K02963 RP-S18, 1.58E-004 4 protein S18 59356, JCVI_SCAF_10966269 51009, JCVI_SCAF_10966277 42493, peptide deformylase JCVI_SCAF_10966270 K01462 PDF, 2.90E-004 5 [EC:3.5.1.88] 11531, JCVI_SCAF_10966262 45080, JCVI_SCAF_10966275 70656, JCVI_SCAF_10966272 DNA polymerase 15520, K02334 dpo bacteriophage-type 3.03E-004 4 JCVI_SCAF_10966281 [EC:2.7.7.7] 70308, ribose 5-phosphate JCVI_SCAF_10966271 K01808 rpiB 3.23E-004 3 isomerase B [EC:5.3.1.6] 04658, D-beta-D-heptose 7- phosphate kinase / D- beta-D-heptose 1- JCVI_SCAF_10966269 K03272 gmhC, 3.34E-004 3 phosphate 72106, adenosyltransferase [EC:2.7.1.167 2.7.7.70] tRNA 2-thiouridine JCVI_SCAF_10966274 K11179 tusE, synthesizing protein E 3.77E-004 2 29578, [EC:2.8.1.-] prolyl 4-hydroxylase JCVI_SCAF_10966271 K00472 E1.14.11.2 3.88E-004 2 [EC:1.14.11.2] 67647, JCVI_SCAF_10966269 adenylate kinase 52198, K00939 E2.7.4.3, 4.10E-004 4 [EC:2.7.4.3] JCVI_SCAF_10966269 21742, K00612 E2.1.3.- carbamoyltransferase JCVI_SCAF_10966271 5.50E-004 4 [EC:2.1.3.-] 56527, JCVI_SCAF_10966270 09191, JCVI_SCAF_10966269 62337, JCVI_SCAF_11016685 10950, ribonucleoside- JCVI_SCAF_10966270 K00526 E1.17.4.1B, diphosphate reductase 5.74E-004 4 32617, beta chain [EC:1.17.4.1] JCVI_SCAF_10966283 76142, JCVI_SCAF_10966269 dTDP-glucose 4, 6- 61316, K01710 E4.2.1.46, 7.00E-004 5 dehydratase [EC:4.2.1.46] JCVI_SCAF_10966271 58059, adenylylsulfate kinase JCVI_SCAF_10966271 K00860 cysC 1.20E-003 3 [EC:2.7.1.25] 38013, curli production JCVI_SCAF_10966269 K06214 csgG assembly/transport 2.35E-003 2 09592, component CsgG oxaloacetate JCVI_SCAF_10966272 K01572 E4.1.1.3B, decarboxylase, beta 2.44E-003 2 51362, subunit [EC:4.1.1.3] JCVI_SCAF_10966278 dCMP deaminase 44348, K01493 comEB 3.11E-003 2 [EC:3.5.4.12] JCVI_SCAF_10966268 68761, JCVI_SCAF_10966271 K03642 rlpA rare lipoprotein A 3.28E-003 2 96549, JCVI_SCAF_10966270 DNA polymerase I 58519, K02335 DPO1, 3.28E-003 6 [EC:2.7.7.7] JCVI_SCAF_10966272 82997, formate dehydrogenase, JCVI_SCAF_10966273 K00124 E1.2.1.2B1 3.38E-003 2 beta subunit 89014, JCVI_SCAF_11016686 NAD(P)H-quinone 99781, K05580 ndhI oxidoreductase subunit I 3.61E-003 2 JCVI_SCAF_10966270 [EC:1.6.5.3] 89417, K00971 manC, mannose-1-phosphate JCVI_SCAF_10966272 3.68E-003 3 guanylyltransferase 68413, [EC:2.7.7.13] JCVI_SCAF_10966270 71151, JCVI_SCAF_10966274 09136, JCVI_SCAF_10966273 K13256 psiE protein PsiE 3.74E-003 2 30481, JCVI_SCAF_10966275 DNA-directed RNA 63526, K03006 RPB1, polymerase II subunit 5.79E-003 2 JCVI_SCAF_10966276 RPB1 [EC:2.7.7.6] 43471, JCVI_SCAF_10966268 ribonucleoside- 69772, K10808 RRM2 diphosphate reductase 7.32E-003 2 JCVI_SCAF_10966280 subunit M2 [EC:1.17.4.1] 38475, JCVI_SCAF_10966270 iron-sulfur cluster 41884, K13628 iscA, 7.73E-003 2 assembly protein JCVI_SCAF_10966269 34369, RNA polymerase JCVI_SCAF_10966273 K03087 SIG2, nonessential primary-like 7.90E-003 2 69111, sigma factor