Curriculum Vitae
Dr. Nizar M. Mhaidat
Assistant Professor
PhD, Clinical Oncology & Immunology
January 2010 Dr. Nizar Mhaidat:
Jordan University of Science and Technology
Faculty of Pharmacy
Department of Clinical Pharmacy
PO. Box 3030, Irbid 22110, Jordan
Phone:
Work: 0096227201000-23542 or -26774
Home: 0096227300039
Mobile: 00962785338533
Email: [email protected]
Education:
PhD Clinical Oncology & Immunology, 2006, Cancer Research Unit,
Faculty of Medicine, The University of Newcastle, NSW, Australia.
MS.c Clinical Pharmacy, 2001, Faculty of Pharmacy, Jordan University of Science & Technology, Jordan.
BS.c Pharmacy, 1998, Faculty of Pharmacy, Jordan University of
Science & Technology, Jordan.
High school, 1994, Green Hill International High School, Athens, Greek. Position Held and Experience:
1. Chairman of the Clinical Pharmacy Department at Jordan University
of Science & Technology, JUST, 2007.
2. Assistant Professor, Clinical Oncology and Immunology; JUST, 2006.
3. Active member of Jordanian Food & Drug Administration (JFDA) of
drug re-registration, 2008.
4. Head of Clinical Pharmacy Department in King Abdullah University
Hospital (KAUH), 2008.
5. Active member of the Jordanian Pharmaceutical Continuous Health
Education, 2007.
6. Active reviewer of Journal of cellular and molecular medicine, 2008.
7. Active member of the American Association of Cancer Research
(AACR), 2007.
8. Head of the internal pharmacy (KAUH), 2001-2003.
9. Clinical Pharmacist at the KAUH, 1999-2001.
10. General Manager of the local market; Al-Noor drug store, 1998-1999.
Publications and International Congresses Presentations:
1. Nizar M. Mhaidat, Yufang Wang, Kelly A. Kiejda, Xu Dong Zhang, and Peter Hersey: Docetaxel-Induced Apoptosis in Melanoma Cells is Dependent on Activation of Caspase-2; Molecular Cancer Therapeutics, 2007. 2. Nizar M. Mhaidat, Xu Dong Zhang, Chen Chen Jiang, and Peter Hersey: Docetaxel-induced apoptosis of human melanoma is mediated by activation of JNK and inhibited by the map kinase ERK1/2 pathway; Clinical Cancer Research, 2007. 3. Chen Chen Jiang, Li Hua Chen, Susan Gillespie, Kelly A. Kiejda, Nizar Mhaidat, Yu Fang Wang, Rick Thorne, Xu Dong Zhang, and Peter Hersey: Tunicamycin sensitize human melanoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by up-regulation of TRAIL-R2 via the unfolded protein response; Cancer Research, 2007. 4. Rick F. Thorne, Nizar Mhaidat, Kylie Ralston, and Gordon F. Burns; Shed gangliosides provide detergent-independent evidence for type-3 glycosynapses, BBRC, 2007. 5. Rick F. Thorne, Nizar Mhaidat, Kylie Ralston, and Gordon F. Burns; CD36 is a receptor for oxidized high-density lipoprotein: Implications for the development of atherosclerosis, FEBS Letters, 2007. 6. Nizar M. Mhaidat, XD Zhang, John Allen, Kelly Kiejda, Rodney Scoot, and Peter Hersey: Temozolomide Induces Senescence but not Apoptosis in Human Melanoma Cells; British Journal of Cancer, 2007. 7. Nizar M. Mhaidat, Rick Thorne, XD Zhang, and Peter Hersey: Regulation of docetaxel-induced apoptosis of human melanoma cells by different isoforms of protein kinase c; Molecular Cancer Research, 2007. 8. Nizar M. Mhaidat, Rick Thorne, XD Zhang, and Peter Hersey: Docetaxel-induced apoptosis of human melanoma is determined by the level of beta tubulin III. FEBS Letters, 2008. 9. Nizar Mhaidat, Xu Dong Zhang, Ping Wang, Susan Gillespie, and Peter Hersey. Antimicrotubule agent-induced activation of ERK1/2 protects human melanoma cells from apoptosis mediated by c-Jun N-terminal kinase. American Association for Cancer Research (AACR) Annual Meeting, USA, 2005. 10.Nizar Mhaidat, Xu Dong Zhang, Chen Chen Jiang, and Peter Hersey. Overcoming resistance of human melanoma to chemotherapy-induced apoptosis, AACR Annual Meeting, USA, 2006. 11.Nizar Mhaidat, Jing Jing Wu, Xu Dong Zhang, and Peter Hersey. Human Melanoma Cells Selected for Resistance to Apoptosis by Prolonged Exposure to Cisplatin, HMRI annual meeting, Australia, 2005. 12.Nizar M. Mhaidat, Rick Thorne, XD Zhang, and Peter Hersey. Docetaxel induces JNK-dependent apoptosis of human melanoma by induction of ER stress, Apoptosis, 2008. 13.Nizar M. Mhaidat, XD Zhang, and Peter Hersey. Overcoming resistance to apoptosis in cancer therapy. Adv Exp Med Biol. 2008. 14.Nizar M. Mhaidat, Peter Hersey. Endoplasmic reticulum; Foe or Friend in Cancer Cells. Int Rev Cytol, 2006. 15. Nizar M. Mhaidat, Karem Al-zoubi, Suleiman Al-Sweedan. Prevalence of depression in cancer patients. Supportive cancer care, 2009. 16. Karem Al-zoubi, Nizar M. Mhaidat. Bacterial resistance: awareness among medical teams (physicians, pharmacists and nurses) in north Jordan. Jordan Pharmaceutical Journal, 2009. 17. Nizar M. Mhaidat. Sensitization of colorectal cancer cells to paclitaxel-induced apoptosis by inhibition of MEK is caspase-4 dependant (In press), 2009. 18.Ahmad Al-Kofahi, Nizar M. Mhaidat. Screening of Jordanian medicinal plants for inhibition against clinical isolates of Helicobacter Pylori (submitted). 19.Nizar M. Mhaidat. Involvement of ER stress in chemotherapy- induced apoptosis of cancer cells. Advances in cancer research; from Lab. To Clinic. AACR Meeting in Jordan, 2008. 20. Karem Alzoubi, Nizar Mhaidat, Sayer Al azzam. Prevalence of migraine and tension-type headache among adult in Jordan. J. Headache Pain, 2009. 21.Nizar M. Mhaidat, Feras Alali, Sina Matalqah, Ismail Matalka, Saied Jaradat, Noor Al-Sawalha, Rick Thorne. Inhibition of MEK sensitizes paclitaxel-induced apoptosis of human colorectal cancer cells by downregulation of GRP78. Anticancer Drugs, 2009. 22.Al-Azzam SI, Al-Ajlony MJ, Al-Khateeb T, Alzoubi KH, Mhaidat N, Ayoub A. An audit of the precipitating factors for haemolytic crisis among glucose-6-phosphate dehydrogenase-deficient paediatric patients. J Med Screen., 2009. 23.Nizar Mhaidat, UPR signalling in colorectal cancer. ACCR Meeting in Boston, USA, 2009.
Current Research Projects:
1. Chemotherapy-induced apoptosis of cancer cells. 2. Death and survival signal transduction pathways in human cancer cells. 3. Endoplasmic reticulum (ER) stress and unfolded protein response (UPR); Implications in cancer management. 4. Endosomes formation and resistance to Taxanes-induced apoptosis. 5. Multidrug resistance protein in clinical response of cancer patients. Supervision of MSc thesis:
1. Nour Ahmad Sawalha, Paclitaxel-Induced ER-Stress of Human colorectal Cancer, 2007. 2. Aseera Mefleh Quwaimani, Altholactone-induced apoptosis of human colorectal cancer, 2008. 3. Sohad Ali Barakat, Involvement of MEK/ERK signaling pathway in the resistance of human colorectal cancer cells to doxorubicin-induced apoptosis, 2008. 4. Reem Mazen Al-Hammori, In vitro toxicity study of altholactone on human colorectal cancer cells: comparison with 5-Fourouracil, 2009. 5. Saleh Naser Abu-Shuqair, Annonacin; Evaluation of antitumour activity and safety index in colorectal cancer and normal cells, 2009. 6. Haeder Kathem Rabeie, Annonacin; Evaluation of antimicrobial activity and safety index, 2009. 7. Maha Burhan Al-Omari, Evaluation of colchicine effect on Cytokine Production from Peripheral Blood Mononuclear Cells of Type 1 Diabetic Patients, 2009. 8. Osama Shoqran, Evaluation of MDR1 polymorphism in Hodgkin Lymphoma patients, 2009. 9. Ibrahim Hamdan, Synthesis and biological evaluation of oxadiazole derivatives, 2010. 10. Israa Trad, Determination the antibiotic susceptibility of Pseudomonas aeruginosa and Staphylococcus aureus on biofilm bacteria: an in vitro study, 2010.