PHS 398 (Rev. 9/04), Biographical Sketch Format Page s6

Principal Investigator (Last, First, Middle):

BIOGRAPHICAL SKETCH Follow the formats and instructions below for all key personnel.

NAME POSITION TITLE Tamara Hershey, Ph.D. Associate Professor

CDI USER NAME

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Earlham College; Richmond, IN B.A. 1988 Psychology Washington Univ in St. Louis; St. Louis, MO Ph.D. 1996 Neuropsychology Long Island Jewish Medical Center, Glen Oaks, NY Intern 1995-6 Neuropsychology Washington Univ. School of Medicine, St. Louis, MO Postdoc 1996-2000 Neuroimaging

A. Positions and Honors. 1995-96: Clinical Neuropsychology Intern. Long Island Jewish Medical Center, Glen Oaks, NY 1996-2000: Postdoctoral Fellow, Washington University School of Medicine, St. Louis, MO 2001-2003: Instructor in Psychiatry, Washington University School of Medicine, St. Louis, MO 2003: Instructor in Neurology, Washington University School of Medicine, St. Louis, MO 2003-2008: Assistant Professor of Psychiatry, Washington University School of Medicine, St. Louis, MO 2004-2008: Assistant Professor of Radiology and Neurology, Washington University School of Medicine, St. Louis, MO 2008-present: Associate Professor (with tenure) of Psychiatry, Radiology and Neurology, Washington University School of Medicine, St. Louis, MO Honors: Phi Beta Kappa; Senior Thesis, Departmental, College Honors; Earlham College (1988), Washington University Graduate Fellowship (1992), James S. McDonnell Summer Institute in Cognitive Neuroscience Travel Award (1992), Washington University Dissertation Fellowship (1995), Epilepsy Foundation of America Postdoctoral Award (1996-97), Long Island Jewish Medical Center Research Award (1996-97), Alzheimer’s Disease and Related Disorders Program Research Award (1998-99), Juvenile Diabetes Foundation International, Research Award (1998-00), James S. McDonnell Higher Brain Function Postdoctoral Award (1999), National Research Service Award, National Institute of Neurological Disorders and Stroke (1999-01), Career Development Award, National Institute of Neurological Disorders and Stroke (2001-06), John Merck Scholar Nominee from Washington University School of Medicine (2003), Dorismae and Harvey A. Friedman Award for Aging Research (2005), Licensed Psychologist and Health Care Provider, Missouri (1999-present; Tourette Syndrome Association Scientific Advisory Board (2008-present).

C. Selected peer-reviewed publications (in chronological order). 1. Wu J.C., Gillin J.C., Buchsbaum M.S., Hershey T.G., Hazlett E., Sicotte N., Bunney W.E. Jr. (1991). The effect of sleep deprivation on cerebral glucose metabolic rate in normal humans assessed with positron emission tomography. Sleep, 14(7),155-67. 2. Wu J.C., Buchsbaum M.S., Hershey T.G., Hazlett E., Sicotte N., Johnson, J.C. (1991). PET in generalized anxiety disorder. Biological Psychiatry, 29, 1181-99. 3. Wu J.C., Gillin J.C., Buchsbaum M.S., Hershey T., Johnson, J.C., Bunney W.E. Jr. (1992). Effect of sleep deprivation on brain metabolism of depressed patients. American Journal of Psychiatry, 149(4), 538-43. 4. Wu J.C., Buchsbaum M.S., Johnson J.C., Hershey T.G., Wagner E.A., Teng C., Lottenberg S. (1993). Magnetic resonance and positron emission tomography imaging of the corpus callosum size, shape, and metabolic rate in unipolar depression. Journal of Affective Disorders, 28(1), 15-25. 5. Newcomer, J.W., Craft, S., Hershey, T., Askins, K., Bardgett, M.E. (1994). Glucocorticoid-induced impairment in declarative memory performance in adult humans. Journal of Neuroscience, 14(4), 2047-53. 6. Hvidberg, A., Fanelli, C.G., Hershey, T., Terkamp, C., Craft, S., & Cryer, P.E. (1996). Impact of recent antecedent hypoglycemia on hypoglycemic cognitive dysfunction in nondiabetic humans. Diabetes, 45, 1030-1036. 7. Hershey, T., Craft, S., Bhargava, N, & White, N. (1997). Memory and insulin dependent diabetes mellitus (IDDM): Effects of childhood onset and severe hypoglycemia. Journal of the International Neuropsychological Society, 3, 509-520.

CDI (Rev. 8/08) Page Biographical Sketch Format Page 8. Hershey, T., Craft, S., Glauser, T. & Hale, S. (1998). Short-term and long-term memory following early temporal lobe dysfunction. Neuropsychology, 12(1), 52-64. 9. Newcomer, J.W., Craft, S., Askins, K., Hershey, T., Bardgett, M., Csernansky, J.G., Gagliardi, A.E. (1998). Decreased sensitivity to glucocorticoid-induced impairment in declarative memory performance in schizophrenia. Psychoneuroendocrinology, 23(1) 65-72. 10. Ovalle, F., Fanelli, C.G., Paramore, D.S., Hershey, T., Craft, S., Cryer, P.E. (1998). Brief twice weekly episodes of hypoglycemia reduce detection off clinical hypoglycemia in type 1 diabetes mellitus. Diabetes, 47, 1472-1479. 11. Hershey, T., Black, K.J., Stambuk, M.K., Carl, J.C., McGee-Minnich, L., Perlmutter, J.S. (1998). Altered thalamic response to levodopa in Parkinsons disease patients with dopa-induced dyskinesias. Proceedings of the National Academy of Sciences, 95(20), 12016-12021. 12. Hershey, T. and Perlmutter, J.S. (1998). Estimating the preclinical parkinsonian period with positron emission tomography. Neurology Network Commentary, 2(3), 157-161. 13. Fanelli, C.G., Paramore, D.S., Hershey, T., Craft, S., Cryer, P.E. (1998). Impact of nocturnal hypoglycemia on hypoglycemic cognitive dysfunction in type 1 diabetes mellitus. Diabetes, 47, 1920-1927. 14. Newcomer, J.W., Farber, N.B., Jevtovic-Todorvic, V., Selke, G., Kelly, A., Hershey, T., Craft, S., Olney, J.W. (1999). Ketamine-induced NMDA receptor hypofunction as a model of memory impairment in schizophrenia. Neuropsychopharmacology, 20(2), 106-118. 15. Newcomer, J.W., Selke, G., Melson, A.K., Hershey, T., Craft, S., Richards, K., Alderson, A. (1999). Dose-dependent cortisol-induced decrease in declarative memory in humans. Archives of General Psychiatry, 56(6), 527-33. 16. Hershey, T., Bhargava, N., Sadler, M., White, N., Craft, S. (1999). Standard vs. Intensive insulin treatment in children with type 1 diabetes mellitus: Effects on memory and motor speed. Diabetes Care, 22(8), 1318-1324. 17. Hershey, T., Black, K.J., Carl, J., Perlmutter, J.S. (2000). Dopa-induced blood flow responses in non-human primates. Exp Neurol, 166(2), 342-349 18. Black, K.J., Hershey, T., Perlmutter, J.S. (2000). Diffuse temporal lobe activation by a dopamine D1 full agonist in primates. J Neurophysiol, 84(1), 549-557 19. Racette BA, Hartlein JM, Hershey T, Mink JW, Perlmutter JS, Black KJ: Clinical features and comorbidity of mood fluctuations in Parkinson's disease. J Neuropsychiatry Clin Neurosci 14(4), 438-442. 20. Perlmutter, J.S., Mink, J.W., Bastian, A.J., Zackowski, K., Hershey, T., Miyawaki, E., Koller, W., Videen, T.O. (2002). Blood flow responses to deep brain stimulation of thalamus. Neurology, 58(9), 1388-1394. 21. Black, K.J., Hershey, T., Koller, J.M., Videen, T.O., Mintun, M.A., Price, J.L., Perlmutter, J.S. (2002). A possible substrate for dopamine-related changes in mood and behavior: Prefrontal and limbic effects of a D3-preferring dopamine agonist. Proceedings of the National Academy of Sciences, 99(26), 17113-17118. 22. Hershey, T., Lillie, R., Sadler, M., White, N.H.. (2002) The effect of severe hypoglycemia on cognition and memory in children and adolescents with Type 1 diabetes mellitus. Diabetes, Nutrition and Metabolism 15(6), 426-429. 23. Hershey, T, Lillie, R., Sadler, M., White, N. (2003) Severe hypoglycemia and long-term spatial memory in children with type 1 diabetes mellitus: A retrospective study. Journal of the International Neuropsychological Society. 9, 740- 750. 24. Hershey, T., Black, K.J., Carl, J.L., McGee-Minnich, L., Perlmutter, J.S. (2003) Chronic treatment and disease severity alter brain responses to levodopa in PD. Journal of Neurology, Neuroscience and Psychiatry, 74, 844-851. 25. Black, K.J., Carl, J.L., Hartlein, J.M., Warren, S., Hershey, T., Perlmutter, J.S. (2003) Rapid intravenous loading of levodopa for human research: Clinical results. Journal of Neuroscience Methods. 127(1), 19-29. 26. Hershey, T., Revilla, F., Loepker, A., McGee-Minnich, L., Antenor, J., Videen, T., Mink, J.W., Perlmutter, J.S. (2003). Cortical and subcortical blood flow effects of subthalamic nucleus stimulation in PD. Neurology, 61(6), 816-821. 27. Hogue, C.W., Lillie, R., Hershey, T., Birge, S., Nassief, A.M., Thomas, B., Freedland, K. (2004). Gender influence on cognitive function after cardiac surgery. Annals of Thoracic Surgery, 76(4), 1119-11125. 28. Lyons-Warren, A., Lillie, R., Hershey, T. (2004). Short and long-term spatial delayed response performance across the lifespan. Developmental Neuropsychology, 26(3):661-78. 29. Hershey, T., Lillie, R., Sadler, M., White, N. (2004). A prospective study of severe hypoglycemia and spatial delayed response in children with T1DM. Pediatric Diabetes, 5(2), 63-71. 30. Hershey, T., Revilla, F., Schneider Gibson, P., Wernle, A., Dowling, J., Perlmutter, J.S. (2004) Stimulation of STN impairs aspects of cognitive control in PD. Neurology, 62(7), 1110-4. 31. Hershey, T., Black, K.J., Hartlein, J., Barch, D.M., Braver, T., Carl, J.L., Perlmutter, J.S. (2004) Cognitive- pharmacological fMRI in Tourette syndrome: A pilot study. Biological Psychiatry, 55(9), 916-925. 32. Hershey, T., Black, K.J., Hartlein, J., Braver, T., Barch, D.M., Carl, J.L., Perlmutter, J.S. (2004) Dopaminergic modulation of response inhibition: An fMRI study. Brain Research, Cognitive Brain Research, 20(3), 438-448. 33. Black, K.J., Hershey, T, Hartlein, J.M., Carl, J.L., Perlmutter, J.S. (2005) Parkinson’s disease patients with levodopa-related mood fluctuations have increased posterior cingulate response to acute levodopa. Neuropsychopharmacology, 30(3):590-601. 34. Hershey, T., Perantie, D.C., Warren, S.L., Zimmerman, E.C., Sadler, M., White, N.H. (2005). Frequency and timing of severe hypoglycemia (SH) affects spatial memory in children with type 1 diabetes mellitus (T1DM). PHS 398/2590 (Rev. 09/04) Page 2 Biographical Sketch Format Page Diabetes Care, 28, 2372-2377. 35. Hogue, C.W., Hershey, T. Dixon, D. Fucetola, R., Nassief, A. Freedland, K.E., Thomas, B. Schechtman, K. (2006). Preexisting cognitive impairment in women before cardiac surgery and its relationship with C-reactive protein concentrations. Anesth Analg, 102:1602–1608. 36. Weiss, E.M., Hershey, T., Karimi, M., Racette, B., Tabbal, S., Mink, J.W., and Perlmutter, J.S. (2006). Relative risk of spread of symptoms among the focal onset primary dystonias. Movement Disorders. 21(8):1175-81 37. Hershey, T and Mink, J.W. (2006). Using functional neuroimaging to study the brain’s response to deep brain stimulation. Neurology, 66(8), 1142-1143. 38. Powers, W.J., Videen, T.O., Markham, J., McGee-Minnich, L., Antenor-Dorsey, J.V., Hershey, T., Perlmutter, J.S. (2007) Selective defect of in vivo glycolysis in early Huntington’s disease striatum. Proceedings of the National Academy of Sciences. 104(8):2945-9. 39. Hogue, C.W., Freedland, K., Hershey, T., Fucetola, R., Nassief, A., Barzilai, B., Thomas, B., Davila-Roman, V., Birge, S., Dixon, D., Schechtman, K. (2007). Failure of 17ß-estradiol to provide protection against neurological complications after cardiac surgery for postmenopausal women. Stroke 38(7):2048-54. 40. Powers, W.J., Haas, R.H., Le, T., Videen, T.O., Hershey, T., McGee-Minnich, L., Perlmutter, J.S. (2007) Normal platelet mitochondrial complex I activity in Huntington's Disease. Neurobiology of Disease, 27(1):99-101. 41. Perantie, D., Wu, J., Lim, A., Warren, S. Koller, J., Black, K.J., Hershey, T. (2007) Brain volume differences associated with severe hypoglycemia and chronic hyperglycemia in children with T1DM. Diabetes Care 30(9):2331-7. 42. Videen, T.O., Campbell, M.C., Tabbal, S.D., Karimi, M., Hershey, T., Perlmutter, J.S. (2008) Validation of a fiducial-based atlas registration method for subthalamic nucleus localization and its application to deep brain stimulation. J Neurosci Methods, 168(2):275-81. 43. Foster, E.R, Black, K.J, Antenor-Dorsey, J.A., Perlmutter, J.S, Hershey, T. (2008). Motor asymmetry and substantia nigra volume are related to spatial delayed response performance in Parkinson disease. Brain and Cognition. Jun;67(1):1-10 44. Hogue, C.W. Jr, Fucetola, R.., Hershey, T., Nassief, A.., Dávila-Román, V.G., Barzilai, B., Thomas, B., Schechtman, K.B., Freedland, K. (2008). The role of postoperative neurocognitive dysfunction on quality of life for postmenopausal women 6 months after cardiac surgery. Anesth Analg. 2008 Jul;107(1):21-8. 45. Hershey, T., Wu, J., Perantie, D., Weaver, P., Karimi, M., Tabbal, S., Perlmutter, J.S. (2008). Unilateral vs. bilateral STN DBS effects on working memory and motor function in Parkinson disease. Exp Neurol Apr;210(2):402-8. 46. Perantie, D., Lim, A., Wu, J., Warren, S.L., Hayden, T., Sadler, M., White, N.H., Hershey, T. (2008) Effects of prior hypoglycemia and hyperglycemia on cognition in children with type 1 diabetes mellitus. Pediatr Diabetes. 2008 Apr;9(2):87-95. 47. Hogue CW, Fucetola R, Hershey T, Freedland K, Dávila-Román VG, Goate AM, Thompson RE. (2008). Risk factors for neurocognitive dysfunction after cardiac surgery in postmenopausal women. Ann Thorac Surg. Aug;86(2):511-6 48. Campbell, M.C., Karimi, M., Videen, T.O., Weaver, P.M., Tabbal, S.D., Perlmutter, J.S., Hershey,T. (2008). Neural correlates of STN DBS-induced impairment in cognitive function. Neuropsychologia, 46(13): 3162-9. 49. Karimi, M., Golchin, N., Tabbal, S.D., Hershey, T., Videen, T.O., Mink, J.W., Perlmutter, J.S. (2008). Bilateral subthalamic nucleus stimulation-induced regional blood flow responses correlate with improvement of motor signs in Parkinson disease. Brain, 131(Pt 10): 2710-9. 50. Foster, E.R., McDaniel, M.A., Repovs, G., Hershey, T. (2009). Prospective memory is differentially impaired in Parkinson disease across levels of executive demand in both the laboratory and everyday life. Neuropsychology, 23(3): 347-58. 51. DeAlwis, D., Myerson, J, Hershey, T., Hale, S. (2009). Children’s higher-order cognitive abilities and the development of primary and secondary memory. Psychonomic Bulletin & Review, 16(5): 925-30 52. Hershey, T., Perantie, D., Wu, J., Weaver, P., Black, K.J., White, N.H. (2010). Hippocampal volumes in youth with type 1 diabetes. Diabetes, 59(1): 236-41.

D. Research Support. Ongoing: R01 NS058797-02 Hershey 7/1/08-6/30/13 $263,681 Mapping mood in the subthalamic nucleus in PD This study tests the hypotheses that DBS STN can alter mood acutely depending upon the precise location of stimulation.

R01 DK064832-07 Hershey 8/1/03-7/31/13 $215,000 Glycemic control, brain structure and cognitive development in T1DM This study continues to follow a cohort of adolescents with T1DM and their non-diabetic siblings to determine the neurological consequences of hyperglycemia and hypoglycemia exposure.

PHS 398/2590 (Rev. 09/04) Page 3 Biographical Sketch Format Page DK064832-07S1 Hershey 8/1/03-7/31/11 $5,306 Glycemic Control, Brain Structure and Cognition in Youth with T1DM This administrative supplement will provide a rich research experience in diabetes and clinical neuroscience to promising summer undergraduate students, as well as enhancing the efficiency and productivity of the parent grant.

U10 HD056526-01 (White, Study Chair) Role: Cognitive Core Director 09/27/07 – 08/31/12 $140,001 DirecNet-2 The overall purpose of DirecNet-2 is to develop strategies to prevent hypoglycemia during treatment of diabetes in children and young adults.

U54 RR024992-02 (Polonsky) Role: Director of Neuropsych Service 9/17/07 – 5/31/12 $109,923 Washington University Institute of Clinical and Translational Sciences (Perlmutter) Brain, Behavior and Performance Unit (BBPU)

R01 MH73856-04 (Black) Role: Co-Investigator 2/15/05-1/31/11 $259,795 Dopaminergic Effects on Cortical Function in Tourette’s This study examines the ability of dopamine to modulate brain activity patterns induced by cognitive tasks in patients with Tourette syndrome.

American Parkinson Disease Association (Perlmutter) Role: Investigator 1999-2011 $100,000 APDA Advanced Research Center for PD

R01 NS41509-08 (Perlmutter) Role: Co-Investigator 5/01/04-7/31/11 $475,256 Mechanism of deep brain stimulation This study investigates how deep brain stimulation alters cognition and blood flow in PD

R01 NS040068-09 (Paulson) Role: PI of Subcontract 9/1/09-8/31/13 $84,520 Neurobiological Predictors of Huntington's Disease PREDICT-HD is an international 30-site observational study of persons at-risk for Huntington's disease (HD). The ultimate goal of PREDICT-HD is to define the neurobiology of HD sufficiently to allow clinical trials of potential disease-modifying therapies before at-risk individuals have diagnosable symptoms of the disease.

Pending: R01 DK085575-01 Hershey 7/1/10 – 6/30/15 $350,000 Central Dopamine Receptors in Obesity The study examines D2 receptors in the brains of obese and lean individuals, how they are related to reward sensitivity and how they change with time and weight loss.

1 P50 NS071667-01 (Perlmutter) Role: PI of Project 4: Neuroimaging and Cognitive Phenotype of LRRK2 7/1/10-6/30/15 $1,493,384 PD Translational Research: From Mouse to Human This Udall center focuses on providing a clear connection between neuroimaging biomarkers and pathophysiology of parkinsonism with the ultimate goal of developing biomarkers to help identify early evidence of underlying brain pathology that can be distinguished from evidence of later brain injury.

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