Supplemental Table. Results of the Systematic Search Strategy.*

Supplemental Table. Results of the systematic search strategy.* Database No.of Citations PubMed 458 Cochrane 1328 Web of Science 574 Embase 642 Total 3002 *Explicit search strategy: #1 Search Antidepressive*[Title/Abstract]

#2 Search (SNRI*[Title/Abstract] OR “Serotonin–norepinephrine reuptake inhibitor*”[Title/Abstract] OR “serotonin noradrenalin reuptake inhibitor”[Title/Abstract] OR “serotonin–noradrenaline reuptake inhibitor*”[Title/Abstract] OR venlafaxin*[Title/Abstract] OR milnacipran[Title/Abstract] OR duloxetin*[Title/Abstract] OR levomilnacipran[Title/Abstract] OR desvenlafaxin*[Title/Abstract] OR sibutramine[Title/Abstract])

#3 Search (SSRI*[Title/Abstract] OR “serotonin* reuptake inhibitor*”[Title/Abstract] OR “serotonin* re-uptake inhibitor*”[Title/Abstract]

OR fluoxetin*[Title/Abstract] OR fluvoxamin*[Title/Abstract] OR paroxetin*[Title/Abstract] OR sertralin*[Title/Abstract] OR citalopram[Title/Abstract] OR escitalopram[Title/Abstract] OR dapoxetin*[Title/Abstract])

#4 Search (TCA*[Title/Abstract] OR tricyclic*[Title/Abstract] OR amoxapine[Title/Abstract] OR clomipramine[Title/Abstract] OR trimipramine[Title/Abstract] OR desipramine[Title/Abstract] OR doxepin[Title/Abstract] OR imipramine[Title/Abstract] OR maprotiline[Title/Abstract] OR amitriptyline[Title/Abstract] OR nortriptyline[Title/Abstract] OR protriptyline[Title/Abstract] OR dothiepin[Title/Abstract] OR lofepramine[Title/Abstract] OR opipramol[Title/Abstract] OR dibenzepin[Title/Abstract])

#5 Search (SARI*[Title/Abstract] OR “serotonin uptake inhibitor*”[Title/Abstract] OR trazodone[Title/Abstract] OR nefazodone[Title/Abstract] OR cianopramine[Title/Abstract] OR litoxetine[Title/Abstract] OR lubazodone[Title/Abstract] OR vilazodone[Title/Abstract] OR eaooehdohoie[Title/Abstract] OR vortioxetine[Title/Abstract])

#6 Search (MAOI*[Title/Abstract] OR “monoamine oxidase inhibitor*”[Title/Abstract] OR isocarboxazid[Title/Abstract] OR nialamide[Title/Abstract] OR iproniazid[Title/Abstract] OR phenelzine[Title/Abstract] OR hydracarbazine[Title/Abstract] OR tranylcypromine[Title/Abstract] OR moclobemide[Title/Abstract] OR pirlindole[Title/Abstract] OR toloxatone[Title/Abstract] OR rasagiline[Title/Abstract] OR selegiline[Title/Abstract])

#7 Search (NaSSA*[Title/Abstract] OR “noradrenergic[Title/Abstract] AND specific serotonergic antidepressant”[Title/Abstract] OR aptazapine[Title/Abstract] OR esmirtazapine[Title/Abstract] OR mianserin[Title/Abstract] OR mirtazapine[Title/Abstract] OR setiptiline[Title/Abstract] OR cianopramine[Title/Abstract] OR litoxetine[Title/Abstract])

#8 Search (NDRI*[Title/Abstract] OR “norepinephrine–dopamine reuptake inhibitor*”[Title/Abstract] OR vortioxetine[Title/Abstract] OR amfebutamone[Title/Abstract] OR amineptine[Title/Abstract] OR bupropion[Title/Abstract] OR desoxypipradrol[Title/Abstract] OR dexmethylphenidate[Title/Abstract] OR difemetorex[Title/Abstract] OR diphenylprolinol[Title/Abstract] OR ethylphenidate[Title/Abstract] OR fencamfamine[Title/Abstract] OR fencamine[Title/Abstract] OR lefetamine[Title/Abstract] OR methylphenidate[Title/Abstract] OR nomifensine[Title/Abstract] OR “oxolinic acid”[Title/Abstract] OR pipradrol[Title/Abstract] OR prolintane[Title/Abstract] OR pyrovalerone[Title/Abstract] OR tametraline[Title/Abstract])

#9 Search (NRI*[Title/Abstract] OR NERI*[Title/Abstract] OR ARI*[Title/Abstract] OR “norepinephrine reuptake inhibitor”[Title/Abstract]

OR “adrenergic reuptake inhibitor”[Title/Abstract] OR atomoxetine[Title/Abstract] OR reboxetine[Title/Abstract] OR edivoxetine[Title/Abstract] OR viloxazine[Title/Abstract] OR maprotiline[Title/Abstract] OR nisoxetine[Title/Abstract] OR lortalamine[Title/Abstract] OR amedalin[Title/Abstract] OR daledalin[Title/Abstract] OR talopram[Title/Abstract] OR talsupram[Title/Abstract] OR tandamine[Title/Abstract] OR esreboxetine[Title/Abstract]) #10 Search (#1 or #2 or #3 or #4 or #5 or #6 or #7 or #8 or #9) #11 Search (headache[Title/Abstract] OR “headache disorders”[Title/Abstract] OR headach*[Title/Abstract] OR migrain*[Title/Abstract]

OR cephalgi*[Title/Abstract] OR cephalalgi*[Title/Abstract]) #12 Search (#10 and #11)

Supplemental Figure 1. Likelihood of experiencing an at least 50% reduction in migraine headaches compared with placebo

Supplemental Figure 2. Sensitivity analyses excluding trials with crossover designs for continiuous outcomes compared with placebo

Supplemental Figure 3. Likelihood of experiencing an at least 50% reduction in migraine headaches compared amitriptyline with SSRIs or SNRIs

Supplemental Figures 4a. ‘Risk of bias’ graph: review authors’ judgements about each risk of bias item presented as percentages across all included trials. Supplemental Figures 4b. ‘Risk of bias’ summary: review authors’ judgements about each risk of bias item for each included trials Supplemental Figure 5a. Inverted funnel plots of continiuous outcomes when compared with placebo. Supplemental Figure 5b. Inverted funnel plots of acceptability between between tricyclic antidepressants and placebo.