Bio 11 Spring 2012

BIO 11 Spring 2012

Emerging Infectious Diseases: How Microbes Rule the World

Class meets at 9L in LSC 100: M, W, F 8:45 AM – 9:50 AM. The x-hour is Th 8:45-9:50 AM and will be used throughout the term.

Professors Mary Lou Guerinot 325 LSC Office Hours: Tues 4-6 PM Wed 3-5 PM

Brad Taylor 332 LSC Office Hours: Mon 3-5 PM Tues 3-5 PM

Overview Biology 11 is the introductory course for all students interested in pursuing study in biology. There are several offerings of Bio 11 each year. Each is designed to provide a synthetic overview of the life sciences and to introduce the fundamental ideas, processes and theories on which the modern life sciences are built. Different offerings of Biology 11 have different themes that the instructors have chosen to introduce fundamental concepts and develop a perspective on the life sciences. Bio 11 has two main goals. The first is to stimulate interest in the science of life. The second is to introduce you to problem solving and encourage critical thinking in the life sciences.

Readings Required: Flu: The Story of the Great Influenza Pandemic of 1918 and the Search for the Virus That Caused It. By Gina Kolata. Available at Wheelock Books or you can get it on Amazon.com

Readings from the primary literature will be assigned throughout the term and will be available via Blackboard in dated subfolders within the Lectures folder.

Recommended: Emerging Infectious Diseases: A Guide to Diseases, Causative Agents, and Surveillance. 1st edition. Lisa A. Beltz. John Wiley and Sons, Inc. ISBN: 978-0-470-39803-6. Available in paperback at the Wheelock Books. A copy will be on permanent reserve at Dana Library as will Brock: Biology of Microorganisms, 13th Edition.

Blackboard We have set up a Blackboard site (https://www.dartmouth.edu/~blackboard/) for Bio 11. The specific reading assignments for each class, as well as PowerPoint presentations, will be available in dated subfolders within the Lectures folder on Blackboard.

Lecture recordings We will be putting recordings of our lectures onto Blackboard. However, if the technology fails, Bio 11 Spring 2012 which it invariably does, then some lectures may not be recorded.

NOTE REGARDING USE OF MATERIALS POSTED to BLACKBOARD ALL materials on our Blackboard site, including the recorded lectures, may not be posted on another website, broadcast, or distributed in electronic or print form to anyone else. Redistributing this material violates fair use, copyright, and privacy rights of the instructors and your fellow classmates. Thank you for understanding!

Assessment of Your Academic Performance We will have 4 quizzes during the X hour (Thursdays 8:45-9:50 AM). Quizzes will account for 75% of your overall grade in the class. Quizzes will focus on the topics covered in the preceding lectures. However, note that as the course progresses, we will take opportunities to link each week’s topics with earlier ones; these connections will be reflected in the quizzes. 20% of your grade will be based on your performance on the final exam. The final will cover all topic areas. It will be less detailed than the quizzes, and will emphasize major concepts, integration and synthesis. The remaining 5% of your grade will be based on the presentation of your emerging infectious disease (EID) reports.

Academic Honesty Academic honesty is essential. The following is quoted directly from the Dartmouth College Student Handbook: "Students who submit work that is not their own or who commit other acts of academic dishonesty forfeit the opportunity to continue at Dartmouth." The complete text of the Academic Honor Principle is in the Student Handbook or at (http://www.dartmouth.edu/~deancoll/documents/handbook/conduct/standards/honor.html). Please read the Honor Principle carefully; you are responsible for knowing and understanding the Honor Principle, and adhering to its letter and spirit. Any violations of the Honor Principle in this course must be referred to the Committee on Standards and can result in your suspension for multiple terms, or, in the most extreme cases, separation from the College.

Special Circumstances We encourage students with learning, physical, or psychiatric disabilities that may need special classroom accommodations to make an appointment to see Prof. Guerinot or Taylor by the end of the second week of the term. All discussions will be confidential, although we may need to consult the Student Accessibility Services office to discuss implementation of special requests.

We recognize that some students may wish to take part in religious observances that fall during the term. Should you have a religious observance that conflicts with your participation in the course, please speak with Professor Guerinot or Professor Taylor by the end of the second week of the term to discuss appropriate accommodations. Bio 11 Spring 2012

Daily Schedule Mar Mon What is an infectious disease? MLG 26 History of Microbiology Mar Wed How can we understand the patterns of infectious diseases? MLG 28 Mar Thurs No class 29 Mar Fri Using mathematical models to study infectious diseases BT 30

April Mon Main factors responsible for emerging infectious diseases BT 2 April Wed Class exercise: How does an epidemic spread? BT/ 4 MLG April Thurs Quiz #1 5 April Fri How do disease organisms work? MLG 6 Bacteria, Archaea, viruses, protists, fungi April Mon How do disease organisms work? MLG 9

April Wed How do disease organisms work? MLG 11 April Thurs Group projects working session 12 April Fri Pathogen effects on host behavior BT 13

April Mon Reciprocal evolution between a host and its disease organism BT 16 April Wed Why can’t we ever defeat a disease organism? MLG 18 Antibiotic Resistance; XDR TB April Thurs Quiz #2 19 April Fri Why can’t we ever defeat a disease organism? PART II MLG 20

April Mon The role of ecological interactions in Lyme disease BT 23 April Wed Importance of species diversity to emerging infectious diseases BT 25 {include recent gut microbiome work and obsesity}

April Thurs MOVIE 26 Bio 11 Spring 2012

April Fri Effects of land use change on emerging infectious diseases BT 27

April Mon Plant Pathogens and why you should care MLG 30 May 2 Wed MOVIE May 3 Thurs Quiz #3 May 4 Fri Transgenic approaches to vaccine development MLG

May 7 Mon Influenza MLG May 9 Wed Discussion of the book Flu by Gina Kolata MLG group #7 presentations on the research moratorium and redaction of recent influenza papers in Nature and Science May Thurs groups 1, 3, and 9 presentations 10 May Fri Malaria and its impact on human population genetics BT 11

May Mon groups 4, 5, and 10 presentations 14 May Wed SARS and the role of travel and trade in emerging infectious BT 16 diseases May Thurs Quiz #4 17 May Fri Impacts of climate change and extreme weather events on BT 18 infectious diseases

May Mon groups 2, 6 and 8 presentations 21 May Wed HIV MLG 23 May Thurs 24 May Fri HIV MLG 25

May Mon Memorial Day Holiday – No Class 28 May Wed Origins of major human infectious diseases BT 30 June 2 Sat Review Session MLG 6 PM BT June 4 Mon FINAL EXAMINATION 8AM