Megan M. Cartwright

MEGAN M. CARTWRIGHT

CONTACT Email: [email protected]

EDUCATION Ph.D. Candidate in Environmental Toxicology, University of Washington, Seattle, WA. Expected defense Fall 2015.  Thesis: Multi-walled carbon nanotube-induced lung pathology is modulated by mouse strain, glutathione status, and nanotube characteristics.  Advisor: Dr. Terrance Kavanagh

B.S. in Biochemistry, Ohio State University, Columbus, OH. Graduated 2006.

HONORS, AWARDS, & GRANTS NIEHS Travel Scholarship, NIEHS Population-Based Rodent Resources for Environmental Health Sciences Meeting, 2015.

Graduate Student Travel Award, University of Washington Graduate School, 2014.

Recipient of Pilot Project Award, NIEHS Center for Ecogenetics & Environmental Health, University of Washington, 2013.

Member, Phi Beta Kappa Honor Society, Ohio State University, 2006.

Graduated Magna cum Laude, with Distinction in Biochemistry, with Honors and Distinction in the Arts and Sciences, Ohio State University, 2006.

Dean’s List, Ohio State University, 2002 – 2006.

University Tradition Scholarship, Ohio State University, 2002 – 2006.

Dean’s Undergraduate Research Fund, Ohio State University, 2005 – 2006.

Pressey Honors Endowment, Ohio State University, 2006.

Undergraduate Student Government Academic Enrichment Grant, Ohio State University, 2006.

RESEARCH EXPERIENCE Graduate Research Assistant, University of Washington, 09/10 – present.  Investigating physicochemical-genetic interactions underlying carbon nanotube-induced lung inflammation, fibrosis, and function in vivo

M.M. Cartwright / Page 1 of 6  Investigated protective effect of growth factors on neuronal cytoskeleton in Parkinson’s disease in vitro model  Developed assay for predicting liver damage from serum samples  Cloned and characterized organophosphate-sensitive esterase domain of human Neuropathy Target Esterase

Research Technician II, Seattle Biomed, 01/08 – 04/10.  Characterized pregnancy-associated malaria vaccine candidate target  Promoted from Research Technician I to II

Research Technician Intermediate, University of Michigan Health System, 08/06 – 08/07.  Characterized genetic, metabolic, and biomechanical properties of sepsis- associated bacteria

Student Researcher, Comparative Orthopedic Laboratory, Ohio State University, 05/05 – 06/06.  Fulfilled research and thesis requirements for Undergraduate Honors Thesis  Investigated knockdown of Tumor Necrosis Factor-alpha in primary osteoarthritis through RNA interference in cultured guinea pig chondrocytes

Student Research Assistant, Department of Neuroscience, Ohio State University, 06/05 – 09/05.  Maintained mouse colony for epilepsy studies

Student Research Assistant, Department of Evolution, Ecology, and Organism Biology, Ohio State University, 06/04 – 09/04.  Collected field samples for long-term national study of controlled burns in forestland

TEACHING EXPERIENCE Graduate Teaching Assistant, University of Washington, 09/11 – 12/11. Course: Exploring Environment and Health Connections (ENV H 111)  Led weekly discussion section  Lectured for toxicology unit  Instructed and evaluated students on writing about environmental health and related science topics

Graduate Teaching Assistant, University of Washington, 01/12 – 03/12. Course: Environmental and Occupational Health (ENV H 511)  Lectured for environmental chemicals and toxicology unit  Graded student exams

AFFILIATIONS & LEADERSHIP

M.M. Cartwright / Page 2 of 6 Board Member, Engage, University of Washington, 08/14 – present.  Developing curriculum and fundraising for science communication workshops geared to graduate students

Secretary, Association for Women in Science – Seattle Chapter, 07/14 – present.  Documenting and maintaining records of Board meetings  Assisting with planning and execution of public events to promote women’s participation in science and technology

Board Member, Bioscience Careers Committee, University of Washington, 06/12 – present.  Organizing graduate student-run seminars hosting Ph.D.-level speakers on non-academic science careers

Student Member, Society of Toxicology, 03/14 – present.

Student Member, Pacific Northwest Association of Toxicologists, 08/13 – present.

Volunteer, Paws on Science, Pacific Science Center, 2013 – present.  Developing and running child-friendly experiments to promote public understanding of toxicology and molecular biology

Science Fair Judge, Seattle-area schools, 2011 – present.  Judging middle and high school science fair projects

RESEARCH COLLABORATIONS Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, 07/14 – 08/14.  Characterized multi-walled carbon nanotubes using helium ion microscopy, scanning electron microscopy, X-ray photoelectron spectroscopy, and Raman spectroscopy.

Gordon Group, New York University Langone Medical Center, 04/13 – present.  Analyzing lung tissue samples collected by Gordon Group from multiple strains of mice exposed to carbon nanotubes.

Posner Group, University of Washington, 06/13 – 09/14.  Characterized multi-walled carbon nanotubes by measuring zeta potentials and hydrodynamic diameters.

PRESENTATIONS Cartwright M. Vaping: History, Health, and Heigl. Invited presentation for middle and high school health teachers as part of environmental health continuing education unit. Seattle, WA: 2014.

M.M. Cartwright / Page 3 of 6 Cartwright M. Nanotechnology & Nanotoxicology. Invited public talk for Public Health Café, Seattle, WA: 2014.

Cartwright M. Faster Laptops, Better Drugs, Worse Lungs: The Perils and Promises of Carbon Nanotubes. Invited public talk at Town Hall Seattle, Seattle, WA: 2014.

PUBLICATIONS

Baker PE, Cole TB, Cartwright MM, Suzuki SM, Thummel TE, Lin YS, Co AL, Rettie AE, Kim JH, Furlong CE. Identifying safer anti-wear triaryl phosphate additives for jet engine lubricants. Chemico-Biological Interactions. 2013 Mar;203(1):257-64.

Avril M, Cartwright MM, Hathaway MJ, Smith JD. Induction of strain-transcendent antibodies to placental-type isolates with VAR2CSA DBL3 or DBL5 recombinant proteins. Malaria Journal. 2011 Feb;10(1):36.

Avril M, Cartwright MM, Hathaway MJ, Hommel M, Reiter K, Fried M, Narum DL, Beeson JG, Smith JD. Immunization with VAR2CSA-DBL5 recombinant protein elicits broadly cross-reactive antibodies to placental Plasmodium falciparum-infected erythrocytes. Infection & Immunity. 2010 May;78(5):2248-56.

Avril M, Hathaway MJ, Cartwright MM, Gose S, Narum DL, Smith JD. Optimizing expression of the pregnancy malaria vaccine candidate VAR2CSA in Pichia pastoris. Malaria Journal. 2009 Jun 29;8:143.

Chung H, Cartwright MM, Bortz DM, Jackson TL, Younger JG. Dynamical system analysis of Staphylococcus epidermidis bloodstream infection. SHOCK. 2008 Nov;30(5):518-26.

POSTERS Cartwright M, Schmuck S, Chisholm C, Corredor C, Posner J, Shutthanandan V, Baer DR, Kavanagh T. Glutathione deficiency modulates susceptibility to multi-walled carbon nanotube-associated acute lung pathology in mice. Poster presented at Pacific Northwest Association of Toxicologists, Seattle, WA: 2014.

Cartwright M, Schmuck S, White C, Corredor C, Botta D, Scoville D, Chishol C, Posner J, Gordon T, Kavanagh T. A comparative in vivo screening of nine classes of multi-walled carbon nanotubes for acute lung toxicity in mice. Poster presented at Society of Toxicology, Phoenix, AZ: 2014.

Cartwright M, Scoville D, Schmuck S, An D, Carosino C, White C, Corredor C, Gao X, Botta D, Chisholm C, Posner J, Gordon T, Altemeir W, Parks W, Kavanagh T. Characterization of pulmonary function and toxicity in mice following exposure to quantum dots or multi-walled carbon nanotubes. Poster presented at Symposium on NIEHS Centers for Nanotechnology Health Implications Research Consortium, Los Angeles, CA: 2013.

M.M. Cartwright / Page 4 of 6 Cartwright M, Schmuck S, White C, Corredor C, Botta D, Scoville D, Chishol C, Posner J, Gordon T, Kavanagh T. A comparative in vivo screening of nine classes of multi-walled carbon nanotubes for acute lung toxicity in mice. Poster presented at Pacific Northwest Association of Toxicologists, Seattle, WA: 2013.

Cartwright MM, Suzuki S, Cole T, Baker P, Furlong C. Recombinant human Neuropathy Target Esterase in inhibited in vitro by tri-o-cresyl phosphate’s cyclic metabolite. Poster presented at Pacific Northwest Association of Toxicologists, North Bonneville, WA: 2011.

Cartwright MM, Kavanagh TJ. Development of an assay for predicting acetaminophen- induced liver damage in mice based on serum levels of cell-free mitochondrial DNA. Presentation for 2011 Dept. of Environmental & Occupational Health Sciences Ph.D. Students Rotation Talks, Seattle, WA: 2011.

Avril M, Cartwright MM, Hathaway MJ, Hommel M, Beeson JG, Smith JD. Immunization with VAR2CSA DBL5 recombinant proteins elicits broadly cross-reactive antibodies to placental type, CSA-binding infected erythrocytes. Poster presented at American Society of Tropical Medicine and Hygiene 57th Annual Meeting, New Orleans, LA: 2008.

Chung H, Cartwright M, Thompson A, Jackson T, Bortz D, Younger J. Neutropenic Staphylococcus epidermidis bacterimia in a multicompartment pharmacokinetic system. Acad Emerg Med 14:S178-179. Poster presented at 2007 Society for Academic Emergency Medicine, Chicago, IL: 2007.

Cartwright M, Bender R, Younger J. Nitrogen limitation promotes spontaneous flocculation by encapsulated Klebsiella pneumoniae. Poster presented at 4th American Society of Microbiology Conference on Biofilms. Quebec City, Quebec, Canada: 2007.

Younger J, Cartwright M. Nonparametric statistical analysis of bacterial aggregate flow cytometric sizing data. Poster presented at 4th American Society of Microbiology Conference on Biofilms. Quebec City, Quebec, Canada: 2007.

Chung H, Jackson T, Bortz DM, Cartwright M, Younger J. Multiple-compartment bacterial clearance kinetics during murine bacteremia. J Crit Care 21(4):359-360. Poster presented at 5th International Conference on Complexity in Acute Illness. Washington, D.C.: 2006.

Cartwright M, Santangelo K, Bertone A. Down-regulation of Tumor Necrosis Factor-α in Dunkin-Hartley guinea pig chondrocytes using RNAi techniques. Poster presented at Denman Undergraduate Research Forum. Ohio State University, Columbus, OH: 2006.

Cartwright M, Santangelo K, Bertone A. Down-regulation of Tumor Necrosis Factor-α in Dunkin-Hartley guinea pig chondrocytes using RNAi techniques. Poster presented at

M.M. Cartwright / Page 5 of 6 College of Biological Sciences Annual Undergraduate Research Colloquium. Ohio State University, Columbus, OH: 2006.

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