Updated February 2011
CURRICULUM VITAE - Armand Zini, MD, FRCSC
Telephone: (514) 484-8810 H (514) 345-3511 W Fax: (514) 724-2718 e-mail: [email protected]
PROFESSIONAL EXPERIENCE
Hospital Appointments
July 1996 – February 2004: Mount Sinai Hospital, Toronto St Michael’s Hospital, Toronto
March 2004-present: St. Mary’s Hospital, Head, Division of Urology, Montreal McGill University Health Center, Montreal
University Appointments
July 1996 – February 2004: Associate Professor, Department of Surgery, University of Toronto
February 2004-present: Associate Professor, Department of Surgery, McGill University
POSTGRADUATE TRAINING
1994 - 1996 The Population Council and Cornell University, New York, NY Fellowship in Male Infertility
1991 - 1994 McGill University, Montreal, Quebec Resident in Urology
1989 - 1991 McGill University, Montreal, Quebec Resident in General Surgery
EDUCATION
1985 - 1989 McGill University, Montreal, Quebec Medical Doctor, Master of Surgery (MD, CM)
1982 - 1985 McGill University, Montreal, Quebec Bachelor of Science with Distinction in Biochemistry and Computer Science Armand Zini MD, FRCSC
CERTIFICATION AND LICENSURE
1990 L.M.C.C. Licentiate of the Medical Council of Canada
1994 F.R.C.S.C. Fellow of the Royal College of Surgeons of Canada
GRANTS AND AWARDS
1994 Ferdinand C. Valentine Scholarship for Research Fellowship 1994-1995 The New York Academy of Medicine
1995 Kidney Foundation of Canada Scholarship for Research Fellowship 1995-1996
1996 Canadian Urological Association Foundation Scholarship for Junior Faculty 1996-1997
2002 Physicians Services Incorporated (PSI) Grant, 2002-2004 Project title: Human sperm DNA denaturation and pregnancy outcome after IVF/ICSI
2007 McGill University Health Centre – Research Institute Grant Project title: Influence of varicocele on sperm DNA damage
2008 Canadian Institute of Health Research (CIHR) – Operating Grant: Co-investigator Project title: Sex-susceptibility for fetal origins of adult disease and trans-generational effects
INDUSTRY GRANTS
1998-9 Hoechst Marion Roussel GnRH therapy for idiopathic male infertility
2002-3 Solvay Pharma Andropausal symptoms in infertile men
2002-3 Organon Canada Testosterone and cognition
2006-7 Heinz Inc. Sperm DNA damage: protective effect of lycopene
MEMBERSHIPS
Canadian Medical Association Canadian Urological Association Canadian Fertility and Andrology Society American Society of Andrology American Urological Association American Society for Reproductive Medicine
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ADMINISTRATIVE FUNCTIONS
2002-2004 Secretary Canadian Andropause Society
EDITORIAL ACTIVITIES
Board Member: JARG – Journal of Assisted Reproduction and Genetics (2010 – present)
External Referee: Journal of Andrology (1996-present) Fertility & Sterility (1998-present) Human Reproduction (1999-present) Molecular Human Reproduction (2009-present) Biomed Central Urology (2001-present) Urology (2001-present) Journal of Urology (2001-present) Theriogenology (2004-present) Asian Journal of Andrology (2004-present) International Journal of Andrology (2005-present) The Lancet (2006-present) British Journal of Urology (BJU Int) (2006-present) Journal of Sexual Medicine (2007–present) Biology of Reproduction (2007–present) Reproductive Biology and Endocrinology (2007–present) RBMonline (2007-present) Journal of Clinical Oncology (2010-present)
Editor: Society for the Study of Male Reproduction (SMRU) Newsletter (2000)
Reviewer: CIHR – Canadian Institute for Health Research (2003-present)
UNIVERSITY TEACHING FUNCTIONS
2001.2004 Week Manager for Urology section of Foundations of Medical Practice course
SUPERVISORY EXPERIENCE
Clinical and Post-Doctoral Fellows Project title/theme 1996-97 Don Berardinucci, MD Varicocele and testicular volume 1997-98 Mark Noss, MD Ultrasound evaluation of varicoceles 1998-99 Victor Mak, MD Influence of sperm processing on DNA integrity 1999-2000 Victor Chow, MD GnRH therapy for idiopathic male infertility
3 Armand Zini MD, FRCSC
2000-01 Khaled Kamal, MD Biological variability of sperm DNA integrity 2001-02 Tony Fischer, MD Sperm DNA integrity & cytoplasmic droplets 2003-04 Jeanne O’Brien, MD† Sperm DNA integrity & retention of sperm histones 2004-06 Xiaoyang Zhang, MD Sperm nuclear histones and protamines 2005-07 Jamie Libman, MD (QUA*) Susceptibility of sperm DNA to oxidative stress 2006-08 Jason Boman, MD (QUA*) Role of SH groups in sperm DNA integrity 2007-09 Abdulazziz Baazeem, MD Sperm decondensation and chromatin structure 2010-12 Naif Al-Hathal, MD Sperm nuclear histone retention †American Society of Andrology Diagnostic Research Scholar *Quebec Urological Association Research Scholar
Urology Residents
1996.2004 Rotating residents in the Urology program at the University of Toronto 2004-2010 Rotating residents in the Urology program at McGill University
Elective Students (Research Electives) Project title/theme
1994-95 Lauren Israel Sperm cytoplasmic droplets 1996-97 Nafisa Dharamsi Varicocele embolization & testicular volume 1997-98 Frank Papanicolaou Sperm cytoplasmic droplets & IVF (AFUD Scolar*) 1997-98 Brian Fong Varicocele and testicular volume 1998-99 Marc Freeman Varicocele and residual sperm cytoplasmic droplets 1998-99 Sloan Hechter Varicocele and residual sperm cytoplasmic droplets 2000-01 Aschis Chawla Recurrent varicoceles 2001-02 Peter Stotland GnRH stimulation test & varicocelectomy outcome 2003-04 Ben Bowles Varicocelectomy and advanced female age 2007-08 Adrienne Quirouet Effect of oxidative stress on sperm H2Ax expression 2008-09 Raed Azhar Effect of varicocelectomy on sperm DNA integrity 2009-10 Khalid Alrabeah Effect of sperm DNA damage on IVF pregnancy 2009-10 Gaelle Kornitzer Antisperm antibodies and IVF pregnancy 2010-11 Walid Sharour Effect of varicocelectomy on sperm histones *American Foundation for Urological Diseases (AFUD) Scholarship Award
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INVITED LECTURER
1996 Sperm Aspiration Techniques Urology Update, Toronto, Canada
1998 Evaluation of Male Infertility 17th Congress of the Venezuela Urology Association, Caracas
1998 Advances in Male Infertility 7th Congress of the Morocco Urology Association, Casablanca
1999 Immotile Sperm & ICSI Society for the Study of Male Reproduction, Dallas, Texas
1999 Genetically Abnormal Sperm Canadian Fertility & Andrology Society, Toronto, Canada
1999 Oxidants and Male Infertility American Society for Reproductive Medicine, Toronto, Canada
1999 Sperm Retrieval Urology Update, Toronto, Canada
2000 Evaluation of Male Infertility Michener Institute, Toronto, Canada
2000 Sperm DNA Integrity University of Florence, Florence, Italy
2000 Sperm Retrieval Techniques Andrology Update, Toronto, Canada
2000 Varicocelectomy, Andrology Update, Toronto, Canada
2000 Prostatitis, Urology Update, Toronto, Canada
2002 Male Infertility: State of the Art Society of International Urologists, Stockholm, Sweden
2002 Male Infertility, Urology Update, Toronto, Canada
2004 Lycopene and Male Infertility American Dietician Association, Anaheim, California
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2004 Sperm DNA Damage and Male Infertility Canadian Fertility & Andrology Society, Jasper, Canada
2005 Impact of Heat on Male Infertility Society for the Study of Male Reproduction, San Antonio, Texas
2005 John Collins Lecture: Sperm DNA Damage and Male Infertility American Society for Reproductive Medicine, Montreal, Canada
2005 Treatment of Azoospermic Men Journee de L’Homme Infertile, Hopital Americain, Paris, France
2006 Semen Analysis in the Evaluation of Male Infertility Canadian Fertility & Andrology Society, Montreal, Canada
2007 Varicocele and Male Infertility Canadian Urological Association, Quebec City, Quebec
2007 Vasectomy Reversal or Assisted Reproduction Quebec Urological Association, Montreal, Quebec
2008 Evaluation of the Azoospermic Man Quebec Urological Association, Montreal, Quebec
2008 Clinical Utility of Sperm DNA Testing American Society of Andrology, Albuquerque, New Mexico
2008 Sperm DNA Damage: Clinical Importance Canadian Fertility & Andrology Society, Calgary, Canada
2009 Sperm DNA Damage: Role of Antioxidants International Society of Andrology, Rome, Italy
2009 Sperm DNA Damage: Clinical Utility ESHRE Workshop on Sperm DNA, Stockholm, Sweden
2009 Microsurgical Pearls: vasectomy reversal and varicocelectomy American Society for Reproductive Medicine, Atlanta, Georgia
2010 Sperm DNA and Chromatin Defects: Clinical Utility Genetics of Male Infertility, Salt Lake City, Utah
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LIVE VIDEO PRESENTATIONS
2007 Microsurgical Varicocelectomy Quebec Urological Association, Montreal, Quebec
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PUBLICATIONS
1. Zini A, de Lamirande E, Gagnon C. Reactive oxygen species in semen of infertile patients: levels of superoxide dismutase- and catalase-like activities in seminal plasma and spermatozoa. Int J Androl, 1993; 16:183-188.
2. Zini A, de Lamirande E , Gagnon C. Low levels of nitric oxide promote human sperm capacitation in vitro. J Androl 1995; 16: 424-431.
3. Zini A , Schlegel PN. Catalase mRNA expression in the adult male rat reproductive tract. J Androl 1996; 17: 473-480.
4. Zini A, Mielnik A, Schlegel PN. POU domain gene expression during spermatogenesis. World J Urol 1996; 14: 274-277.
5. Zini A, O'Bryan MK, Magid M, Schlegel PN. The immunohistochemical localization of endothelial nitric oxide synthase in testis, epididymis and vas suggests a possible role for nitric oxide in spermatogenesis, sperm maturation and programmed cell death. Biol Reprod 1996; 55: 935-941.
6. de Lamirande E, Jiang H, Zini A, Kodama H, Gagnon C. Reactive oxygen species and sperm physiology. Rev Reprod 1997; 2: 48-54.
7. Zini A , Schlegel PN. Cu/Zn superoxide dismutase, catalase and glutathione peroxidase mRNA expression in the rat testis after surgical cryptorchidism and efferent duct ligation. J Urol 1997; 158: 659-663.
8. Zini A , Schlegel PN. Identification and Characterization of antioxidant enzyme mRNAs in the rat epididymis. Int J Androl 1997; 20: 86-91.
9. Zini A, Schlegel PN. Expression of glutathione peroxidase mRNA in the adult male rat reproductive tract. Fertil Steril 1997; 68: 689-695.
10. Zini A, Buckspan M, Berardinucci D, Jarvi K. The influence of clinical and subclinical varicocele on testicular volume. Fertil Steril 1997; 68: 671-674.
11. Berardinucci D, Zini A, Jarvi K. Outcome of microsurgical reconstruction in men with suspected epididymal obstruction. J Urol 1998; 159: 831-834.
12. Zini A, Buckspan M, Berardinucci D, Jarvi K. Loss of left testicular volume in men with left varicocele: correlation with grade of varicocele. Arch Androl 1998; 41: 43-47.
13. Zini A , Abitbol J, Girardi SK, Schulsinger D, Goldstein M, Schlegel PN. Germ cell apoptosis and endothelial nitric oxide synthase (eNOS) expression following ischemia-reperfusion injury to the testis. Arch Androl 1998; 41: 63-71.
8 Armand Zini MD, FRCSC
14. Zini A, O'Bryan MK, Israel L, Schlegel PN. Human sperm NADH and NADPH diaphorase cytochemistry: correlation with sperm motility. Urology 1998; 51: 464-8.
15. Jarvi K, Zini A, Buckspan B, Ginsberg B, Asch M, Margolis M. Adverse effects on vaso- epididymostomy outcomes for men with concomitant abnormalities in prostate and seminal vesicle. J Urol 1998; 160:1410-2.
16. Garrels K, Zini A, Casper R, Meriano J, Jarvi K. Comparable pregnancy rates using fresh and frozen epididymal sperm for intracytoplasmic sperm injection. Arch Androl 1998; 41: 159-165.
17. Karakiewicz PI, Zini A, Meshref AW, Bazinet M, Aprikian AG, Elhilali MM. Population- based patterns of radical retropubic prostatectomy use. Urology 1998; 52: 219-223.
18. O'Bryan MK, Zini A, Cheng CY, Schlegel PN. Human sperm endothelial nitric oxide synthase expression: correlation with sperm motility. Fertil Steril 1998; 70: 1143-7.
19. Zini A, Abitbol J, Schulsinger D, Goldstein M, Schlegel PN. Restoration of spermatogenesis after scrotal replacement of experimentally cryptorchid rat testes: assessment of germ cell apoptosis and eNOS expression. Urology 1999; 53: 223-227.
20. Mak V, Zielenski J, Tsui LC, Durie P, Zini A, Martin S, Barry Longley T, Jarvi K. Proportion of cystic fibrosis gene mutations not detected by routine testing in men with obstructive azoospermia. JAMA 1999; 281:2217-24.
21. Zini A, Buckspan B, Jamal M, Jarvi K. Effect of varicocelectomy on the abnormal retention of residual cytoplasm by human spermatozoa. Hum Reprod 1999; 14: 1791-3.
22. Zini A, Mak V, Phang D, Jarvi K. Potential adverse effect of semen processing on human sperm DNA integrity. Fertil Steril 1999; 72: 496-9.
23. Mak V, Zielenski J, Tsui L-C, Durie P, Zini A, Martin S, Barry-Longley T, Jarvi KA. Cystic fibrosis gene mutations and infertile men with primary testicular failure. Hum Reprod 2000; 15: 436-9.
24. Zini A, Garrels K, Phang D. Antioxidant activity in the semen of fertile and infertile men. Urology 2000; 55: 922-6.
25. Papanikolaou F, Chow V, Jarvi K, Fong B, Ho M, Zini A. Effect of adult microsurgical varicocelectomy on testicular volume. Urology 2000; 56: 136-9.
26. Zini A, Defreitas G, Freeman M, Hechter S and Jarvi K. Varicocele is associated with the abnormal retention of cytoplasm by human spermatozoa. Fertil Steril 2000; 74: 461-4.
27. Chow V, Jarvi K, Buckspan M, Barry-Longley T and Zini A. Intranasal GnRH* therapy in men with idiopathic infertility: GnRH stimulation test may predict response to treatment. Fertil Steril 2000; 74: 605-6.
9 Armand Zini MD, FRCSC
28. Mak V, Jarvi K, Freeman M, Hechter S, Buckspan M, Zini A. Smoking is associated with retention of cytoplasm by human spermatozoa. Urology 2000; 56: 463-6.
29. Zini A, Nam RK, Mak V, Phang D, Jarvi K. Influence of initial semen quality on the integrity of human sperm DNA following semen processing. Fertil Steril 74: 824-7, 2000.
30. Zini A, Finelli A, Phang D, Jarvi K. Influence of semen processing technique on human sperm DNA integrity. Urology 56: 1081-84, 2000.
31. Zini A, Bielecki R, Phang D, Zenzes MT. Correlations between two markers of sperm DNA integrity, DNA denaturation and DNA fragmentation, in fertile and infertile men. Fertil Steril 75: 674-77, 2001.
32. Kamal KM, Jarvi K, Zini A. Microsurgical varicocelectomy in the era of art: Influence of initial semen quality on pregnancy rates Fertil Steril 75: 1013-6, 2001.
33. Zini A, O'Bryan MK, Schlegel PN. Nitric oxide synthase (NOS) activity in human seminal plasma. Urology 58: 85-89, 2001.
34. Zini A, Kamal KM, Phang D. Free thiols in human spermatozoa: correlation with sperm DNA integrity. Urology 58: 80-84, 2001.
35. Zini A, Mak V. Post-mortem sperm retrieval is not a urologist’s duty. Contemp Urology 13: 36- 49, 2001.
36. Zini A, Kamal KM, Phang D, Willis J, Jarvi K. Biological variability of sperm DNA denaturation in infertile men. Urology 58: 258-61, 2001.
37. Kamal K, Zini A, Jarvi K. Testicular block using intra-testicular lidocaine: a new anesthetic technique for percutaneous testis biopsy. Can J Urol 9: 1568-70, 2002.
38. Andonian S, Jarvi K, Zini A, Hermo L. Ultrastructural features of the vas deferens from patients undergoing vasectomy and vasectomy reversal. J Androl 23: 691-701, 2002.
39. Zini A, Fischer MA, Mak V, Phang D, Jarvi K. Catalase- and superoxide dismutase-like activities in human seminal plasma. Urol Res 30: 321-3, 2002.
40. Zini A, Fischer MA, Sharir S, Shayegan B, Phang D, Jarvi K. Prevalence of abnormal sperm DNA denaturation in fertile and infertile men. Urology 60: 1069-72, 2002.
41. Zini A. Varicocele: Evaluation and Treatment. J Sex Reprod Med 2:119-124, 2002.
42. Zini A, Schlegel PN. Effect of hormonal manipulation on mRNA expression of antioxidant enzymes in the rat testis. J Urol 169:767-771, 2003.
10 Armand Zini MD, FRCSC
43. Fischer MA, Willis J, Zini A. Human sperm DNA integrity: correlation with sperm cytoplasmic droplets. Urology 61: 207-11, 2003.
44. Deane L, Sharir S, Jarvi K, Zini A. High levels of sperm DNA denaturation as the sole semen abnormality in a patient post-chemotherapy for testis cancer. J Androl 25:23-4, 2004.
45. Zini A, Fischer MA, Nam RK, Jarvi K. Use of alternative and hormonal therapies in male infertility. Urology 63: 141-3, 2004.
46. O’Brien J, Bowles B, Kamal KM, Jarvi K, and Zini A. Does the GnRH stimulation test predict clinical outcome after microsurgical varicocelectomy? Urology 63: 1143-7, 2004.
47. Grober E, O’Brien J, Jarvi K, and Zini A. Preservation of testicular arteries during sub- inguinal microsurgical varicocelectomy: clinical considerations. J Androl 25: 740-743, 2004.
48. Chawla A, O'Brien J, Lisi M, Zini A, Jarvi K. Should all urologists performing vasectomy reversals be able to perform vasoepididymostomies if required? J Urol 172:1048-1050, 2004.
49. Grober E, Chan PTK, Zini A, Goldstein M. Microsurgical Treatment of Persistent or Recurrent Varicocele. Fertil Steril 82: 718-22, 2004.
50. O’Brien J, Bowles B, Kamal KM, Jarvi K, and Zini A. Microsurgical varicocelectomy in couples with advanced female age: natural history in the era of ART. J Androl 2004; 25: 939-43.
51. Chawla A, Bowles B, Zini A. Vasectomy follow-up: clinical significance of rare non-motile sperm in the post-op semen analysis. Urology 2004; 64:1212-5.
52. O’Brien J, Zini A. Human sperm DNA integrity and male infertility. Urology 2005; 65:16-22.
53. Zini A, Blumenfeld A, Libman J, Willis J. Beneficial effect of microsurgical varicocelectomy on human sperm DNA integrity. Hum Reprod 2005: 20:1018-1021.
54. O’Brien J, Lazarou S, Deane L, Jarvi K, and Zini A. Erectile dysfunction and andropausal symptoms in infertile men. J Urol 2005; 174: 132-4.
55. Chawla A, Kulkarni G, Kamal K, Zini A. Microsurgical varicocelectomy for recurrent painful varicoceles. Urology 2005; 66:1072-4.
56. Zini A, Meriano J, Kader K, Jarvi K, Laskin C, Cadesky, K. Potential adverse effect of sperm DNA damage on embryo quality after ICSI. Hum Reprod 2005; 20: 3476-80.
57. San Gabriel M, Zhang X, A Zini A. Estimation of sperm DNA damage by real time gene- specific PCR analysis. Fertil Steril 2006; 85: 797-9.
58. Zini A, Fischer MA, Bellack D, Noss MB, Kamal K, Chow V, Mak V. Technical modification of microsurgical varicocelectomy can reduce operating time. Urology 2006; 67: 803-6.
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59. Zini A, Libman J. Sperm DNA damage: clinical utility in the era of assisted reproduction. CMAJ 2006; 175:495-500.
60. Zhang X, San Gabriel M, A Zini A. Sperm nuclear protamine to histone ratio in fertile and infertile men: evidence of heterogeneous sub-populations of spermatozoa in the ejaculate. J Androl 2006; 27: 414-20.
61. Zini A, Libman J. Sperm DNA damage: importance in the era of assisted reproduction. Curr Opin Urol. 2006;16:428-34.
62. Libman J, Lo K, Jarvi K, Zini A. Beneficial effect of microsurgical varicocelectomy is superior for men with bilateral vs. unilateral repair. J Urol 2006 ; 176: 2602-5.
63. Zini A, San Gabriel M, Zhang X. The histone to protamine ratio in human spermatozoa: comparative study of whole and processed semen. Fertil Steril 2007; 87:217-9.
64. Zini A. Varicocelectomy: microsurgical subinguinal technique is the treatment of choice. CUAJ 2007;1: 273-6.
65. Zhang X, San Gabriel M, Libman J, Phillips, Courchesne A, Zini A. Localization of single- stranded DNA in human sperm nuclei. Fertil Steril 2007; 88:1334-8.
66. Zini A, Boman J, Jarvi K, Baazeem A. Varicocelectomy for advanced paternal age. Urology 2008; 72:109-13.
67. Zini A, Zhang X, San Gabriel M. Sperm nuclear histone H2B: correlation with sperm DNA denaturation and DNA stainability. Asian J Andrology 2008;10:865-71.
68. Boman J, Libman J, Zini A. Microsurgical varicocelectomy for isolated asthenospermia. J Urol 2008; 180:2129-32.
69. Zini A, Boman J, Belzile E, Ciampi A. Sperm DNA damage is associated with an increased risk of pregnancy loss after IVF and ICSI: Systematic review and meta-analysis. Hum Reprod 2008; 23:2663-8.
70. Zini A, Boman J, Baazeem A, Jarvi K, Libman J. Natural history of varicocele management in the era of intra-cytoplasmic sperm injection (ICSI). Fertil Steril 2008; 90:2251-6.
71. Zini A, Boman J. Varicocele: Red herring or red flag? Sem Rep Med. 2009; 27:171-8.
72. Zini A, Baazeem A, Sigman M. Semen analysis and sperm function assays: what do they mean? Sem Rep Med. 2009; 27:115-23.
73. Zini A, Phillips S, Courchesne A, Boman J, Baazeem A, Bissonette F, Kadoch IJ, San Gabriel M. Sperm head morphology is related to high DNA stainability by sperm chromatin structure assay. Fertil Steril 2009; 91:2495-500.
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74. Zini A, Sigman M. Are tests of sperm DNA damage clinically useful?: Pros and Cons. J Androl 2009; 30: 219-229.
75. Baazeem A, Boman J, Libman J, Jarvi K, Zini A. Microsurgical varicocelectomy for infertile men with oligospermia: differential effect of bilateral and unilateral varicocele on pregnancy outcome. BJU Int 2009; 104:524-8.
76. Baazeem A, Zini A. Surgery Illustrated - Surgical Atlas Microsurgical varicocelectomy. BJU Int. 2009;104: 420-7.
77. Zini A, San Gabriel M, Baazeem A. Antioxidants and sperm DNA damage: a clinical perspective. J Assist Reprod Genet 2009, 26:427-32.
78. Zini A, San Gabriel M, Libman J. Lycopene supplementation in vitro can protect human sperm DNA from oxidative damage. Fertil Steril 2010, 94:1033-1036.
79. Delouya G, Baazeem A, Boman JM, Violette P, Saad F, Zini, A. Identification of spermatozoa in archived testicular cancer specimens: implications for bench side sperm retrieval at orchiectomy. Urology 2010 Jun;75(6):1436-40.
80. Libman J, San Gabriel M, Sairam R, Zini A. Catalase can protect spermatozoa of FSH receptor knock-out mice against oxidant-induced DNA damage in vitro. Int J Androl 2010, 33:818- 22.
81. Libman J, Segal R, Baazeem A, Boman JM, Zini A. Microanatomy of the left and right spermatic cords at subinguinal microsurgical varicocelectomy: comparative study of primary and redo repairs. Urology 2010 Jun;75(6):1324-7.
82. Barratt C, Aitken J, de Boer P, Björndahl L, Carrell DT, Perreault SD, Kvist U, Lewis SEM, Perry MJ, Ramos L, Robaire B, Ward S, Zini A. Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications. A position report. Hum Reprod 2010 Apr;25(4):824-38.
83. Zini A, Phillips S, Lefebvre J, Baazeem A, Bissonette F, Kadoch IJ, San Gabriel M. Anti- sperm antibodies are not associated with sperm DNA damage: a prospective study of infertile men. J Reprod Immunology 2010 ;85:205-8.
84. Zini A. Are sperm chromatin and DNA defects relevant in the clinic. Syst Biol Reprod Med. 2011; 57: 78-85.
85. Jarvi K, Lo K, Fischer A, Grantmyre J, Zini A, Chow V, Mak V. CUA Guideline: The workup of azoospermic males. Can Urol Assoc J 2010; 4:163-7.
86. Zini A. CUA Guideline: Vasectomy Update 2010. Can Urol Assoc J 2010; 4:306-309.
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87. Zini A, Lefebvre J, Kornitzer G, Bissonette F, Kadoch IJ, Deane N, Phillips S. Anti-sperm antibodies are not related to fertilization or pregnancy at IVF and ICSI. J Reprod Immunology. 2011; 88: 80-4. 88. Zini A, Azhar R, Baazeem A, San Gabriel M. Effect of microsurgical varicocelectomy on human sperm chromatin and DNA integrity: a prospective trial. Int J Androl 2011; 34:14-9.
89. Hin-Yu VT, Zini A. Finasteride-induced secondary infertility associated with sperm DNA damage: a case report. Fertil Steril (in press).
90. Zini A, Al-Hathal N. Antioxidants and male infertility: fact or fiction? Asian J Andrology 2011 (in press).
91. Zini A, Jamal, W, Cowan L, Al-Hathal N. Is sperm DNA damage associated with IVF embryo quality? A systematic review. J Assist Reprod Genet 2011 (in press).
92. Zini A, Fahmy N, Al-Hathal N, Belzile E, Ciampi A, Kotb A. Anti-sperm antibodies are not associated with pregnancy after IVFand ICSI: systematic review and meta-analysis. Hum Reprod (in press).
SUBMITTED MANUSCRIPTS:
PUBLISHED ABSTRACTS
1. Zini A, de Lamirande E and Gagnon C. Nitric oxide increases capacitation of human spermatozoa. J Androl 1995; 16: (suppl) p28.
2. Zini A and Schlegel PN. Expression of catalase mRNA in the adult male rat reproductive tract, and in the rat testis during sexual maturation. J Androl 1995; 16: (suppl) p35.
3. Tripp B, Hanley J, Zini A, Bazinet M, Elhilali M. Falling rates of transurethral, retropubic and suprapubic prostatectomy in the province of Quebec: temporal trends from 1988 to 1993. J Urol 1995; 153: (suppl) 318A.
4. Zini A, Goldstein M and Schlegel PN. Expression of glutathione peroxidase mRNA in the adult male rat reproductive tract. Fertil Steril 1995; 63: (suppl) s3.
5. Zini A, O'Bryan MK and Schlegel PN. The immunohistochemical localization of nitric oxide synthase (NOS) in the human male reproductive tract and in spermatozoa, suggests a possible role for nitric oxide (NO) in spermatogenesis and sperm maturation and an association with subfertility. Endothelium 1995; 3: (suppl) s8.
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6. O'Bryan MK, Zini A, Schlegel PN and Cheng CY. The cyclic expression of nitric oxide synthase (NOS) in the rat testis is suggestive of a role for NOS in spermatogenesis. Endothelium 1995; 3: (suppl) s85.
7. Zini A, Goldstein M and Schlegel PN. Alterations in catalase and glutathione peroxidase mRNA expression in the rat testis after surgical cryptorchidism and efferent duct ligation. J Androl 1996; 17 (suppl) p35.
8. Zini A, O'Bryan MK and Schlegel PN. Nitric oxide synthase (NOS) activity in human seminal plasma. J Androl 1996 ; 17 (suppl) p34.
9. Zini A, O'Bryan MK, Magid M, and Schlegel PN. The localization of nitric oxide synthase in human testis, epididymis and vas suggests a role for nitric oxide in spermatogenesis and sperm maturation. J Urol 1996; 155: (suppl) 478A.
10. O'Bryan MK, Zini A, Cheng CY, Schlegel PN. eNOS is differentially regulated throughout the spermatogenic cycle in the rat testis. Endocrinology 1996 (suppl).
11. Zini A, Schulsinger D, Goldstein M, Schlegel PN. The localization of inducible nitric oxide synthase (iNOS) in the normal and postischemic rat testis. Fertil Steril 1996; 66: (suppl) S204.
12. Zini A, Schlegel PN. Selective destruction of Leydig cells induces lipid peroxidation in the seminiferous epithelium of the rat testis. Fertil Steril 1996; 66: (suppl) S76.
13. Zini A, Schlegel PN. Effect of hormonal manipulation on mRNA expression of antioxidant enzymes in the rat testis. Biol Reprod 1996; 54: (suppl) S72.
14. Zini A, Buckspan M, Berardinucci D, Jarvi K. Clinical and subclinical varicocele: Effect on testicular volume. Can J Urology 1997; 4: (suppl) 354.
15. Berardinucci D, Zini A, Jarvi K. Idiopathic epididymal obstruction: results of vasoepididymostomy. Can J Urology 1997; 4: (suppl) 354.
16. Zini A, Schlegel PN. Effect of hormonal manipulation on mRNA expression of antioxidant enzymes in the rat testis. Can J Urology 1997; 4: (suppl) 354.
17. Pace K, Jarvi K, and Zini A. The changing face of testicular cancer in Ontario:Temproal trends in mortality and incidence from 1964 to 1993. Can J Urology 1997; 4: (suppl) 357.
18. Garrels K, Zini A, Casper R, Meriano J, Jarvi K. Comparable pregnancy rates using fresh and frozen epididymal sperm for intracytoplasmic sperm injection. J Urol 1997; 157: (suppl) S450.
19. Karakiewicz P, Zini A, Bazinet M, Trudel C, Aprikian A and Elhilali M. Chrarcteristics of radical retropubic prostatectomy in the province of Quebec from January 1988 until December 1993. Br J Urol 1997; 80(suppl 2): p246.
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20. Zini A, Abitbol J, Schulsinger D, Goldstein M and Schlegel PN. Restoration of spermatogenesis after scrotal replacement of experimentally cryptorchid rat testes: assessment of germ cell apoptosis and eNOS expression. Fertil Steril 1997; 68: (suppl).
21. Zini A, Buckspan M, Berardinucci D, Jarvi K. The influence of clinical and subclinical varicocele on testicular volume. Fertil Steril 1997; 68: (suppl).
22. Zini A, O'Bryan MK, Cheng CY, Schlegel PN. Endothelial nitric oxide synthase (eNOS) in human spermatozoa. J Androl 1998; 19(suppl) p40.
23. Papanikolaou F, Greenblatt E, Pritzker K and Zini A. Retention of cytoplasm on human spermatozoa is associated with sperm dysfunction. J Urol 1998; 159: (suppl) S269.
24. Noss MB, Papanikolaou F, Fong B, Buckspan MB, Jarvi K and Zini A. Pre- and post- operative ultrasonography in the assessment of varicoceles: correlation with semen parameters. J Urol 1998; 159: (suppl) S208.
25. Zini A, Jarvi K, Arnett WP, Foussias G, Pappas H, Ghandi S, Melegos DN, Mullen B, Yu H, Srigley J and Diamandis EP. Prostaglandin D synthase in human semen: a potential marker to differentiate obstructive from non-obstructive azoospermia. Fertil Steril 1998; 70: (suppl) S71.
26. Logarakis NF, Bedard Y, Zini A, Buckspan MB, and Jarvi K. High incidence of testicular tumors in infertile men. Fertil Steril 1998; 70: (suppl) S12.
27. Papanikolaou F, Fong B, Jarvi K, Buckspan MB and Zini A. Repair of varicocele in the adult, unlike pediatric varicocelectomy, does not result in catch-up growth of the testicle. Fertil Steril 1998; 70: (suppl) S202.
28. Lee C, Jarvi K and Zini A. Retention of cytoplasm by human spermatozoa: correlation with sperm motility and sperm DNA fragmentation. Fertil Steril 1998; 70: (suppl) S271.
29. Mak V, Jarvi K, Phang D, Buckspan M, Zini A. Adverse effect of semen processing on human sperm DNA integrity. J Urol 1999; 161: (suppl) S282.
30. Mak V, Jarvi K, Freeman M, Hechter S, Buckspan M, Zini A. Smoking is associated with retention of cytoplasm by human spermatozoa. J Urol 1999; 161: (suppl) S343.
31. Arnett WP, Zini A, Jarvi K, Diamandis EP. Prostaglandin D synthase in human semen: a marker to differentiate obstructive from non-obstructive azoospermia. J Urol 1999; 161: (suppl) S280.
32. Mak V, Zielenski J, Tsui LC, Durie P, Zini A, Longley T, Martin S, Jarvi K. Cystic fibrosis gene mutations and infertile men with primary testicular failure. J Urol 1999; 161: (suppl) S345.
16 Armand Zini MD, FRCSC
33. Mak V, Zielenski J, Tsui LC, Durie P, Zini A, Longley T, Martin S, Jarvi K. Obstructive azoospermia: Importance of extensive screening for mutations in the CFTR gene. J Urol 1999; 161: (suppl) S281.
34. Mak V, Phang D, Zini A. Catalase- and superoxide dismutase-like activities in human semen: clinical considerations. Fertil Steril 1999; 72: (suppl) S220.
35. Jarvi K, Zini A, Buckspan M. Significance of Ultrasond-detected, non-palpable testicular masses in infertile males. Fertil Steril 1999; 72: (suppl) S55.
36. Garrels K, Phang D, Zini A. Antioxidant activity in the semen of fertile and infertile men. J Androl 2000; 21(suppl) p53.
37. Chow V, Papanikolaou F, Fong B, Ho M and Zini A. Effect of adult microsurgical varicocelectomy on testicular volume. J Androl 2000; 21(suppl) p53.
38. Finelli A, Jarvi K, Phang D, Zini A. Influence of semen processing technique on human sperm DNA integrity. J Androl 2000; 21(suppl) p53.
39. Andonian S, Durie P, Mak V, Zini A, Jarvi K, Hermo L. Ultrastructure of the vas deferens (VD) from healthy non-vasectomized and vasectomized patients. J Androl 2000; 21(suppl) p37.
40. Chow V, Jarvi K, Buckspan M, Barry-Longley T and Zini A. Intranasal GnRH* therapy in men with idiopathic infertility: GnRH stimulation test may predict response to treatment. J Urol 2000; 163 (suppl) p302.
41. Nam RK, Mak V, Phang D, Jarvi K, and Zini A. Influence of initial semen quality on the integrity of human sperm DNA following semen processing. J Urol 2000; 163 (suppl) p257.
42. Nam RK, Jarvi K, Phang D and Zini A. Influence of seminal superoxide dismutase and catalse-like activity on sperm DNA integrity. J Urol 2000; 163 (suppl) p298.
43. Sharir S, Jarvi K, Phang D and Zini A. Evaluation of sperm DNA integrity in male infertility. J Urol 2000; 163 (suppl) p256.
44. Chow V, Zini A, Meriano J and Jarvi K. Percutaneous vs. microsurgical epididymal sperm aspiration for use in intracytoplasmic sperm injection – a comparison of sperm retrieval techniques. J Urol 2000; 163 (suppl) p256.
45. Zini A, Defreitas G, Freeman M, Hechter S and Jarvi K. Varicocele is associated with the abnormal retention of cytoplasm by human spermatozoa. Fertil Steril 2000; 74: (suppl) p240.
46. Zini A, Bielecki R, Phang D, Zenzes MT. Correlations between two markers of sperm DNA integrity, DNA denaturation and DNA fragmentation, in fertile and infertile men. Fertil Steril 2000; 74: (suppl) p125.
17 Armand Zini MD, FRCSC
47. Zini A, Phang D. Incomplete oxidation of thiols in human spermatozoa: correlation with sperm DNA integrity. Fertil Steril 2000; 74: (suppl) p244.
48. Kamal KM, Zini A, Borrows L, Jarvi K, Nickel C. Prevalence of HPV in semen of infertile and fertile men. J Urol 2001; 165 (suppl) p308.
49. Chew B, Jarvi K, Kamal KM, Willis J, Zini A. Vasoepididymostomy is associated with retention of sperm cytoplasmic droplets. J Urol 2001; 165 (suppl) p334.
50. Kamal KM, Zini A, Phang D. Free thiols in human spermatozoa: correlation with sperm DNA integrity. J Urol 2001; 165 (suppl) p336.
51. Fischer MA, Tsui LC, Corey M, Zielenski J, Durie P, Zini A, Jarvi K. Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in oligoasthenospermic males: genotype-phenotype correlations. J Urol 2001; 165 (suppl) p336.
52. Fischer MA, Tsui LC, Corey M, Zielenski J, Durie P, Zini A, Jarvi K. Cystic fibrosis gene mutations in different categories of male infertility. J Urol 2001; 165 (suppl) p340.
53. Kamal KM, Phang D, Jarvi K, Willis J, Zini A. Biological variability of sperm DNA integrity in semen samples from infertile men. J Urol 2001; 165 (suppl) p346.
54. Kamal KM, Jarvi K, Zini A. The prevalence of bacterial infection in the semen of infertile men. J Urol 2001; 165 (suppl) p346.
55. Fischer MA, Kamal KM, Nam R, Jarvi K, Zini A. Patterns of use of alternative therapies in male infertility patients. J Urol 2001; 165 (suppl) p350.
56. Fischer MA, Kamal KM, Jarvi K, Zini A. The gonadotropin releasing hormone (GnRH) stimulation test may predict pregnancy outcome after microsurgical varicocelectomy. J Androl 2001; 22 (suppl) p110.
57. Kamal KM, Jarvi K, Phang D, Zini A. Adverse effect of semen processing on human sperm DNA integrity is not associated with increased levels of sperm free thiols. J Androl 2001; 22 (suppl) p159.
58. Kamal KM, Phang D, Zini A. Free thiols in human spermatozoa: correlation with sperm DNA integrity. J Androl 2001; 22 (suppl) p161.
59. Kamal KM, Phang D, Jarvi K, Willis J, Zini A. Biological variability of sperm DNA integrity in semen samples from infertile men. J Androl 2001; 22 (suppl) p162.
60. Chew B, Jarvi K, Kamal KM, Willis J, Zini A. Vasoepididimostomy and vasovasostomy are associated with retention of sperm cytoplasmic droplets. J Androl 2001; 22 (suppl) p189.
18 Armand Zini MD, FRCSC
61. Kamal KM, Jarvi K, Zini A. The prevalence of bacterial infection in the semen of infertile men. J Androl 2001; 22 (suppl) p191.
62. Fischer MA, Kamal KM, Jarvi K, Zini A. Gonadotropin releasing hormone (GnRH) stimulation test may predict pregnancy outcome after microsurgical varicocelectomy. Fertil Steril 2001; 76 (suppl) p443.
63. Kamal KM, Jarvi K, Phang D, Zini A. The effect of semen processing on human sperm DNA integrity is not associated with increased levels of sperm free thiols. Fertil Steril 2001; 76 (suppl) p42.
64. Kamal KM, Jarvi K, Zini A. Natural history of varicocelectomy in the era of advanced reproductive technologies. Fertil Steril 2001; 76: (suppl) p239.
65. Shayegan B, Jarvi K, Zini A. Isolated abnormality of sperm DNA integrity in male infertility is uncommon. J Urol 2002; 167 (suppl) p.
66. Shayegan B, Jarvi K, Zini A. Human sperm DNA integrity and seminal anti-oxidant activity in fertile and infertile men. J Urol 2002; 167 (suppl) p.
67. Lazarou SA, Fischer MA, Jarvi K, Zini A. Prevalence of andropause and erectile dysfunction symptoms male infertility patients. J Urol 2002; 167 (suppl) p.
68. Blumenfeld A, Jarvi K, Zini A. Effect of microsurgical varicocelectomy on sperm DNA integrity. J Urol 2003; 169 (suppl) p452.
69. Lisi M, Zini A, Jarvi K. If you can not do a vaso-epididymostomy should you be trying to do a vasectomy reversal? J Urol 2003; 169 (suppl) p408.
70. Lisi M, Zini A, Jarvi K. Sperm banking: recommendations for men undergoing vasoepididymostomy for idiopathic epididymal obstruction. J Urol 2003; 169 (suppl) p411.
71. Deane L, Lazarou SA, Jarvi K, Zini A. Prevalence of andropause and erectile dysfunction male infertility patients. Can J Urology 2003; 4: (suppl) 1864.
72. Perez Y, O’Brien J, Sharir S, Jarvi K, Zini A. Evaluation of sperm DNA integrity, standard semen parameters and pregnancy outcomes in male infertility. J Urol 2004; 171 (suppl) p364.
73. Kader K, Meriano J, Zini A. Effect of Sperm DNA Damage on Fertilization Rates at Intracytoplasmic Sperm Injection (ICSI)– A Single Centre Experience. J Urol 2004; 171 (suppl) p412.
74. O’Brien J, Bowles B, Kamal KM, Jarvi K, and Zini A. The GnRH stimulation test does not predict clinical outcome after microsurgical varicocelectomy. J Urol 2004; 171 (suppl) p411.
19 Armand Zini MD, FRCSC
75. O’Brien J, Bowles B, Kamal KM, Jarvi K, and Zini A. Microsurgical varicocelectomy in couples with advanced female age: natural history in the era of ART. J Urol 2004; 171 (suppl) p511.
76. Chawla A, Bowles B, Zini A. Vasectomy follow-up: clinical significance of rare non-motile sperm in the post-op semen analysis. J Urol 2004; 171 (suppl) p511.
77. O’Brien J, Bowles B, Lazarou SA, Jarvi K, Zini A. Prevalence of andropause and erectile dysfunction in male infertility patients. J Urol 2004; 171 (suppl) p369.
78. Grober E, O’Brien J, Jarvi K, and Zini A. Preservation of testicular arteries during sub- inguinal microsurgical varicocelectomy: clinical considerations. J Androl 2004; 25 (suppl).
79. O’Brien J, Bowles B, Kamal KM, Jarvi K, and Zini A. Microsurgical varicocelectomy in couples with advanced female age: natural history in the era of ART. J Androl 2004; 25 (suppl).
80. San Gabriel M, Zhang X, A Zini A. Estimation of sperm DNA damage by gene-specific PCR analysis. J Androl 2005; 26 (suppl), P59.
81. Zhang X, San Gabriel M, A Zini A. Estimation of nuclear protamine to histone ratio in the spermatozoa of fertile and infertile men. J Androl 2005; 26 (suppl), P57.
82. Zini A, Meriano J, Kader K, Jarvi K, Laskin C, Cadesky K. Influence of Sperm DNA Damage on Reproductive outcomes with ICSI. J Androl 2005; 26 (suppl), P44.
83. A shis K Chawla, Girish Kulkarni, Keith A Jarvi, Armand Zini. Microsurgical varicocelectomy for recurrent varicoceles associated with orchalgia. J Urol 2005; 173 (suppl).
84. Timothy O Davies, Brenden Mullen, Armand Zini, Kirk C Lo, Jennifer Willis, Keith A Jarvi, Potential etiologies and treatment of very high sperm DNA fragmentation found in men with infertility. J Urol 2005; 173 (suppl).
85. Dharm R Singh, Jeanne O'Brien, Ben Bowles, Keith A Jarvi, Armand Zini. LH and not the FSH response to GNRH stimulation predicts the pregnancy outcome after microsurgical varicocelectomy. J Urol 2005; 173 (suppl).
86. Jason M Boman, Aaron Blumenfeld, Jamie Libman, Keith A Jarvi, Jennifer Willis, Armand Zini, Beneficial effect of microsurgical varicocelectomy on human sperm DNA integrity. J Urol 2005; 173 (suppl).
87. Kenneth T Pace, Daniela Ghiculete, Ronald Kodama, Armand Zini, Sid Radomski, Kirk C Lo, Michael Robinette, Lesley K Carr, R John D'A Honey. Shock wave lithotripsy: interim results for a randomized, double-blinded trial to compare shock wave frequencies of 60 and 120 shocks per minute for proximal ureteral stones. J Urol 2005; 173 (suppl).
20 Armand Zini MD, FRCSC
88. San Gabriel M, Zhang X, A Zini A. Estimation of sperm DNA damage by gene-specific PCR analysis. J Androl 2005; 26 (suppl), P59.
89. Zhang X, San Gabriel M, A Zini A. Estimation of nuclear protamine to histone ratio in the spermatozoa of fertile and infertile men. J Androl 2005; 26 (suppl), P57.
90. Zini A, Meriano J, Kader K, Jarvi K, Laskin C, Cadesky K. Influence of Sperm DNA Damage on Reproductive outcomes with ICSI. J Androl 2005; 26 (suppl), P44.
91. San Gabriel M, Zhang X, A Zini A. Estimation of gene-specific sperm DNA damage by real time PCR analysis. Fertil Steril 2005; 84 (suppl).
92. Zhang X, San Gabriel M, A Zini A. Estimation of nuclear protamine to histone ratio in the spermatozoa of fertile and infertile men: evidence of heterogeneous sub-populations of spermatozoa in the ejaculate. Fertil Steril 2005; 84 (suppl).
93. Jamie Libman, Kirk Lo, Keith A Jarvi, Armand Zini. Beneficial effect of microsurgical varicocelectomy is superior for men with bilateral vs. unilateral repair. J Urol 2006 (suppl).
94. Zhang X, San Gabriel M, A Zini A. Sperm nuclear protamine to histone ratio in fertile and infertile men: evidence of heterogeneous sub-populations of spermatozoa in the ejaculate. J Urol 2006 (suppl).
95. Libman J, Baazeem A, Zini A. Influence of arterial and lymphatic anatomy on surgical operating times for microsurgical varicocelectomy. Fertil Steril 2006; 86 (suppl), s373.
96. Libman J, San Gabriel M, Zhang X, Zini A. Direct localization of human sperm DNA damage. Fertil Steril 2006; 86 (suppl), s352.
97. San Gabriel M, Zhang X, Libman J, Zini A. Co-localization of single-stranded DNA and histone H2B in human sperm nuclei: insight on the etiology of sperm DNA damage. J Androl 2007.
98. Boman J, Libman J, Baazeem A, Jarvi K, Zini A. Natural history of varicocele management in the era of intra-cytoplasmic sperm injection (ICSI). Fertil Steril 2007; (suppl).
99. Grunbaum A, Boman J, J Zini A. Varicocelectomy for advanced paternal age. Fertil Steril 2007; (suppl).
100. Boman J, Phillips S, Courchesne A, Kadoch J, Bissonette F, Zini A. Influence of epididymal sperm quality on pregnancy outcome after ICSI. Fertil Steril 2007; (suppl).
101. Libman J, San Gabriel M, Sairam R, Zini A. Catalase can protect spermatozoa of FSH receptor knock-out mice against oxidant-induced DNA damage in vitro. Fertil Steril 2008; (suppl).
102. Libman J, San Gabriel M, Zini A. Lycopene attenuates oxidative sperm DNA damage in vitro. Fertil Steril 2008; (suppl).
21 Armand Zini MD, FRCSC
103. Boman J, Libman J, Zini A. Microsurgical varicocelectomy for isolated asthenospermia. Fertil Steril 2008; (suppl).
104. Baazeem A, Jarvi K, Zini A. Microsurgical varicocelectomy for infertile men with bilateral varicocele. J Urol 2009; (suppl).
105. Baazeem A, Violette P, Boman J, Zini A. Feasibility of sperm retrieval at the time of radical orchiectomy for testis cancer. J Urol 2009; (suppl).
106. Zini A, Jamal, W, Cowan L, Al-Hathal N. Is sperm DNA damage associated with IVF embryo quality? A systematic review. J Androl (in press).
107. Zini A, Fahmy N, Al-Hathal N, Belzile E, Ciampi A, Kotb A. Anti-sperm antibodies are not associated with pregnancy after IVFand ICSI: systematic review and meta-analysis. J Androl (in press).
CHAPTERS AND PROCEEDINGS
1. Zini A, O'Bryan MK, Magid M, Schlegel PN. The immunohistochemical localization of nitric oxide synthase (NOS) in the human male reproductive tract and in spermatozoa, suggests a possible role for nitric oxide (NO) in spermatogenesis and sperm maturation and an association with subfertility. In: The Biology of Nitric Oxide, vol 5. Edited by S. Moncada, J. Stamler, S. Gross and E.A. Higgs. Portland Press, London, UK, 1996 p19.
2. O'Bryan MK, Zini A, Schlegel PN and Cheng CY. The cyclic expression of nitric oxide synthase (NOS) in the rat testis is suggestive of a role for NOS in spermatogenesis. In: The Biology of Nitric Oxide, vol 5. Edited by S. Moncada, J. Stamler, S. Gross and E.A. Higgs. Portland Press, London, UK, 1996 p241.
3. Zini A, Girardi SK, Goldstein M. Varicocele. In: Male Infertility and Sexual Dysfunction. Edited by Wayne Hellstrom. Springer-Verlag, New York Inc. 1997.
4. Zini A, Girardi SK, Goldstein M. Complex Vasal Reconstructions. In: Advances in Urology, Volume 10. Edited by Edward J. McGuire and Larry I. Lipschultz. Mosby, Chicago. 1997.
5. Kamal K, Zini A, Jarvi K. Bacteriospermia in infertile men. In: Andrology in the 21st Century. Edited by B. Robaire, H. Chemes and C.R. Morales. Medimond, Englewood, NJ, USA, 2001, p485- 89.
6. Zini A, Chokron C. Fertility in men with spermatogenesis abnormality. In: Encyclopedia of Endocrine Diseases, Volume 2. Edited by Luciano Martini. Elsevier Science (USA), San Diego, CA, 2004, p52-57.
22 Armand Zini MD, FRCSC
7. Zini A. Varicocele. In: Reproductive Medicine Secrets. Edited by Peter Chan and Marc Goldstein. Henley and Belfus Publishers. 2004.
8. Zini A, Sigman M. Advanced Sperm Fertility Tests. In: Infertility in the Male, 4th Edition. Edited by Larry Lipshultz, Stuart Howards, Craig Niederberger. Cambridge University Press, 2009.
9. Zini A, Maianski Z. Microsurgical Varicocelectomy. In: Glenn’s Urologic Surgery. Edited by XX. Lippincott Williams and Wilkins, 2008.
10. Baazeem A and Zini A. Microsurgical Varicocelectomy. In: BJU Atlas. BJU Int. 2009 ; 104:420-7.
11. Boman J and Zini A. Varicocelectomy. In: Male Infertility, 2nd Edition. Edited by Marc Goldstein and Peter Schlegel. Cambridge University Press, in press.
12. Zini A. In vitro studies of Antioxidants for male reproductive health. In: Antioxidants and Male Infertility. Edited by Sijo Parekattil and Ashok Agarwal. Springer (USA), in press.
13. Zini A. Sperm retrieval in cancerous testes. In: Assisted Reproduction Techniques: Challenges and Management Options. Edited by Khaldoun Sharif. Blackwell Publishing Ltd, Oxford, UK, in press.
BOOKS
1. Sperm DNA Damage: Biological and Clinical Applications in Assisted Reproduction. Edited by Armand Zini and Ashok Agarwal. Springer (USA), in press.
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