FF Principal Investigator/Program Director (Last, First, Middle): Baker, Michael E

FF Principal Investigator/Program Director (Last, first, middle): Baker, Michael E. BIOGRAPHICAL SKETCH NAME POSITION TITLE Michael E. Baker, Ph.D. Research Biochemist

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY (if applicable) Lehigh University, Bethlehem, PA B.S. 1960 Metallurgy Rensselaer Polytechnic Institute, Troy, NY M.S. 1964 Materials Science University of Chicago, Chicago, IL 1965 Chemistry Cornell University, Ithaca, NY Ph.D. 1968 Materials Science

RESEARCH AND PROFESSIONAL EXPERIENCE: Professional Experience 1960-1961 Metallurgist, Pratt & Whitney Aircraft, Middletown, Conn 1968-1971 NIH Fellow, Genetics Dept, Laboratory of Dr. Eric Shooter Chair Dept of Neurobiology 1975-1987, Stanford University, Stanford, CA 1971-1975 Senior Postdoctoral Fellow, Laboratory of Dr. Robert Holley, Nobel Laureate 1968, Salk Institute, San Diego, CA. 1976-1987 Assistant Research Biochemist, Univ. of California, San Diego 1988-1999 Associate Research Biochemist, Univ. of California, San Diego 2000-present Research Biochemist, Univ. of California, San Diego Honors and Awards 1968-1971 NIH Postdoctoral Fellowship 1971-1974 Senior Dernham Fellowship, California Cancer Society Summer -2002 Japan Society for the Promotion of Science, Senior Fellow at Hoshi University, Tokyo

Selected Publications 78. Grundy WN., Bailey TL., Elkan CP., Baker ME. Hidden Markov model analysis of motifs in steroid dehydrogenases and their homologs. Biochem. Biophys Res Commun. 231, 760-766, 1997. 80. Grundy, WN., Bailey, T.L., Elkan, C.P., Baker, M.E. Meta-MEME: Motif-based hidden Markov models of protein families. CABIOS 13, 397-406, 1997. 82. Baker, M.E. Steroid receptor phylogeny and vertebrate origins. Molec Cell Endocrinol 135, 101-107 1997. 83. Baker, M.E., Medlock, K.L., Sheehan D.M. Flavonoids inhibit estrogen binding to rat alpha-fetoprotein. Proc. Soc. Experimental Biol. & Med. 217, 317-321, 1998. 85. Fomitcheva J; Baker ME; Anderson E; Lee GY; Aziz N. Characterization of Ke 6, a new 17beta-hydroxysteroid dehydrogenase, and its expression in gonadal tissues. J. Biol. Chem. 273, 22664-22671, 1998. 91. Baker ME, Yan L, Pear MR. Three-dimensional model of human TIP30, a coactivator for HIV-1Tat-activated transcription, and CC3, a protein associated with metastasis suppression. Cell. Molec. Life Sci. 57, 851-858, 2000. 93. Baker ME. Evolution of 17beta-hydroxysteroid dehydrogenases and their role in androgen, estrogen and retinoid action. Molec. & Cellular Endocrinol. 171, 211-215, 2001. 94. Baker ME. Adrenal and sex steroid receptor evolution: Environmental implications. J. Molec. Endocrinol. 26, 119- 125, 2001. 96. Nakajin S, Itoda M, Ohno S, Takase N, Toyoshima S, Baker ME Deletion of 12 carboxyl-terminal residues from pig 3/,20-hydroxysteroid dehydrogenase affects steroid metabolism. Biochim Biophys Acta 1550, 175-182, 2001. 97. Baker ME Recent insights into the origins of adrenal and sex steroid receptors. J Mol Endocrinol 28, 149-152, 2002. 100. Baker ME Evolution of adrenal and sex steroid action in vertebrates: A ligand-based mechanism for complexity. BioEssays 25, 396-400, 2003. FF Principal Investigator/Program Director BAKER, MICHAEL E. 109. Atanasov AG, Nashev LG, Tam S, Baker ME, Odermatt A. Organotins disrupt the 11beta-hydroxysteroid dehydrogenase type 2-dependent local inactivation of glucocorticoids. Environ Health Perspect. 113, 1600-1606, 2005. 110. Sciotti MA, Tam, S, Wermuth B, Baker, ME. Differences in catalytic activity between rat testicular and ovarian carbonyl reductases are due to two amino acids. FEBS Lett. 580, 67-71, 2006. 113. Baker ME Evolution of metamorphosis: role of environment on expression of mutant nuclear receptors and other signal-transduction proteins. Integr Comp. Biol. 46, 808-814, 2006. 114. Ollikainen N, Chandsawangbhuwana C, Baker ME. Evolution of the thyroid hormone, retinoic acid, ecdysone and liver X receptors. Integr Comp Biol. 46, 815-826, 2006. 115. Baker ME, Chandsawangbhuwana C, Ollikainen N, Structural analysis of the evolution of steroid specificity in the mineralocorticoid and glucocorticoid receptors. BMC Evol Biol, 7:24, 2007. 116. Nashev LG, Chandsawangbhuwana C, Balazs Z, Atanasov AG, Dick B, Frey FJ, Baker ME, Odermatt A. Hexose-6- phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids. PLoS ONE, 2:e561, 2007. 117. Baker ME Amphioxus, a primitive chordate, is on steroids: evidence for sex steroids and steroidogenic enzymes. Endocrinology 148, 3551-3553, 2007. 118. Baker ME, Chandsawangbhuwana C. Analysis of 3D models of octopus estrogen receptor with estradiol: Evidence for steric clashes that prevent estrogen binding. Biochem Biophys Res Commun. 361, 782-788, 2007. 120. Baker ME, Chandsawangbhuwana C. Motif analysis of amphioxus, lamprey and invertebrate estrogen receptors: toward a better understanding of estrogen receptor evolution. Biochem Biophys Res Commun. 371, 724-728, 2008. 122. Baker ME. Trichoplax, the simplest known animal, contains an estrogen-related receptor but no estrogen receptor: Implications for estrogen receptor evolution. Biochem Biophys Res Commun. 375, 623-627, 2008. 123. Gumy C, Chandsawangbhuwana C, Dzyakanchuk AA, Kratschmar DV, Baker ME, Odermatt A. Dibutyltin disrupts glucocorticoid receptor function and impairs glucocorticoid-induced suppression of cytokine production. PLoS ONE 3, e3545, 2008. 124. Balázs Z, Nashev LG, Chandsawangbhuwana C, Baker ME, Odermatt A. Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11beta-hydroxysteroid dehydrogenase 1. Mol Cell Endocrinol 301, 117-122, 2009 125. Baker ME, Ruggeri B, Sprague LJ, Eckhardt-Ludka C, Lapira J, Wick I, Soverchia L, Ubaldi M, Polzonetti-Magni AM, Vidal-Dorsch D, Bay S, Gully JR, Reyes JA, Kelley KM, Schlenk D, Breen EC, Sásik R, Hardiman G. Analysis of endocrine disruption in Southern California coastal fish using an aquatic multispecies microarray. Environ Health Perspect. 117, 223-230, 2009 126. Wu W, Baker ME, Early SA, Bush KT, Nigam SK. Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members. Physiol Genomics 38:116- 124, 2009.. 127. Baker ME, Chang DJ. 3D model of amphioxus steroid receptor complexed with estradiol. Biochem Biophys Res Commun. 386, 516-520, 2009. 128. Baker ME, Chang DJ, Chandsawangbhuwana C. 3D model of lamprey estrogen receptor with estradiol and 15alpha- hydroxy-estradiol. PLoS ONE;4, e6038, 2009. 129. Markov GV, Tavares R, Dauphin-Villemant C, Demeneix BA, Baker ME, Laudet V Independent elaboration of steroid hormone signaling pathways in metazoans. Proc Natl Acad Sci USA. 106, 11913-11918, 2009. 130. Baker ME Evolution of 11beta-hydroxysteroid dehydrogenase-type 1 and 11beta-hydroxysteroid dehydrogenase-type 3. FEBS Lett. 584, 2279-2284, 2010 131. Baker ME. 11beta-hydroxysteroid dehydrogenase-type 2 evolved from an ancestral 17beta-hydroxysteroid dehydrogenase-type 2. Biochem Biophys Res Commun. 399, 215-220, 2010. 132. Baker ME. Origin and diversification of steroids: co-evolution of enzymes and nuclear receptors. Mol Cell Endocrinol. 334, 14-20, 2011. 133. Baker ME, Asnaashari P, Chang DJ, McDonnell S. 3D models of lamprey progesterone receptor complexed with progesterone, 7-hdyroxy-progesterone and 17-hydroxy-progesterone. Steroids. 76, 169-176, 2011. 134. Baker ME. Insights from the structure of estrogen receptor into the evolution of estrogens: Implications for endocrine disruption. Biochem Pharmacol. 82, 1-8, 2011. 135. Odermatt A, Da Cunha T, Penno CA, Chandsawangbhuwana C, Reichert C, Wolf A, Dong M, Baker ME. Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11β-hydroxysteroid dehydrogenase 1. Biochem J. 436, 621-629, 2011. 136. Andrieu T, Bertolini R, Nichols SE, Setoud R, Frey FJ, Baker ME, Frey BM. A novel steroidal antiandrogen targeting wild type and mutant androgen receptors. Biochemical Pharmacol. 82, 1651–1662, 2011. 137. Baker ME, Uh KY, Asnaashari P. 3D models of lamprey corticoid receptor complexed with 11-deoxycortisol and deoxycorticosterone. Steroids 76, 1451-1457, 2011. 138. Baker ME, Uh KY. Evolutionary analysis of the segment from helix 3 through helix 5 in vertebrate progesterone receptors. J Steroid Biochem Mol Biol. 132, 32-40, 2012. 139. Baker ME, Uh KY, Chandsawangbhuwana C. 3D models of human ERα and ERβ complexed with 5-androsten-3β,17β-diol. Steroids 77, 1192-1197, 2012 140. Baker ME, Chandsawangbhuwana C. 3D models of MBP, a biologically active metabolite of bisphenol A, in human estrogen receptor α and estrogen receptor β. PLoS One. 2012, 7, e46078. 141. Baker ME. What are the physiological estrogens? Steroids 78, 337-340, 2013. 142. Weinstain R, Kanter J, Friedman B, Ellies LG, Baker ME, Tsien RY. Fluorescent ligand for human progesterone receptor imaging in live cells. Bioconjug Chem. 24, 766-771, 2013. 143. Baker ME, Funder JW, Kattoula SR. Evolution of hormone selectivity in glucocorticoid and mineralocorticoid receptors. J Steroid Biochem Mol Biol. 137, 57-70, 2013 144. Baker ME, Vidal-Dorsch DE, Ribecco C, Sprague LJ, Angert M, Lekmine N, Ludka C, Martella A, Ricciardelli E, Bay SM, Gully JR, Kelley KM, Schlenk D, Carnevali O, Sášik R, Hardiman G. Molecular analysis of endocrine disruption in hornyhead turbot at wastewater outfalls in southern california using a second generation multi-species microarray.PLoS One 2013 8, e75553. 145. Nashev LG, Atanasov AG, Baker ME, Odermatt A. Cysteine-10 on 17 β-Hydroxysteroid Dehydrogenase 1 Has Stabilizing Interactions in the Cofactor Binding Region and Renders Sensitivity to Sulfhydryl Modifying Chemicals. Int J Cell Biol. 2013;2013:769536, 2013 146. Chandsawangbhuwana C, Baker ME 3D models of human ERα and ERβ complexed with coumestrol Steroids 80, 37–43, 2014. 147. Kattoula SR, Baker ME Structural and evolutionary analysis of the co-activator binding domain in vertebrate progesterone receptors. J Steroid Biochem Mol Biol. 141, 7-15, 2014. 148. Baker ME, Hardiman G. Transcriptional analysis of endocrine disruption using zebrafish and massively parallel sequencing. J Molecular Endocrinology 52, R241-R256, 2014.