University of Oxford

HEALTH EDUCATION THAMES VALLEY – ACADEMIC CLINICAL FELLOWSHIP IN PAEDIATRICS

About Health Education Thames Valley

We are the Local Education and Training Board (LETB) for Thames Valley covering Berkshire, Buckinghamshire and Oxfordshire. Our vision is to ensure the delivery of effective workforce planning and excellent education and training to develop a highly capable, flexible and motivated workforce that delivers improvements in health for the population of Thames Valley. Thames Valley LETB is responsible for the training of some 1500 trainees.

Health Education Thames Valley is a relatively small organisation with a defined geographical area which serves as a single unit of application. In the majority of cases successful candidates will be asked to preference their choice of location for either one or two years. Some programmes will require successful candidates to indicate a location and specialty. Future placements will usually be based on individual training and educational needs. Please note that applications are to the Health Education Thames Valley as a whole. This may mean that you may be allocated to any geographic location within Health Education Thames Valley depending on training needs.

Further particulars for the post of NIHR Academic Clinical Fellow in Paediatrics

Job title - Academic Clinical Fellow Duration of post - Three years

Applications are welcome from trainees at ST 1-3 for this Academic Clinical Fellow post. Academic Clinical Fellowship (ACF) posts have been awarded by the NIHR to University/NHS Trust/Deanery partnerships nationally through competition. Oxford has been very successful attracting 79 ACF and 30 Clinical Lecturer posts to date. These posts form part of the NIHR Integrated Training Pathway, further details of which can be found on the NIHR TCC website http://www.nihrtcc.nhs.uk. The University of Oxford enjoys an international reputation as a world-class centre of excellence in research and teaching. It employs over 7,800 academic, research and support staff across a wide range of academic disciplines.

The Medical Sciences Division, within which the Department of Paediatrics is located, includes the clinical and preclinical departments of the Medical School, plus Experimental Psychology (see http://www.medsci.ox.ac.uk/). The division is one of the major centres for clinical and basic biomedical research in Europe, with more

1 than 2,200 staff on the payroll and 800 postgraduate students. It includes several research Institutes and Units housed in modern buildings. The Division achieved top scores in both the 2001 and 2008 HEFCE research assessment exercises. The annual grant income from external sources for the Medical Sciences Division is over £90 million. The Division fosters the highest possible standards in research, teaching and patient care and seeks to recruit staff that share this vision. The Oxford Medical Sciences Division aims to sustain a high standard both in teaching and research and furthers the development of students by providing an environment in which basic and clinical research are actively pursued at the highest level.

The University Department of Paediatrics has a diverse and actively expanding portfolio of research in paediatric diseases and child health with areas of research in Paediatric Gastroenterology and Nutrition, Global Health, Haematology, Immunology and Infectious Disease and Neurosciences. These themes are discussed below.

Research Themes and Investigators within the University Department of Paediatrics

Paediatric Gastroenterology and Nutrition Dr Peter Sullivan’s Paediatric Nutrition Research Group studies the nutritional consequences of neurological impairment in children. Current studies focus on the impact of neurotrophic nutritional intervention to mitigate the effects of perinatal brain damage. This group also has research projects on infant nutrition, body composition, short gut syndrome, inflammatory bowel disease and coeliac disease. Email:[email protected] Further information is available at: http://www.paediatrics.ox.ac.uk/research/paediatric-gastroenterology-and-nutrition- group-1/

Dr Holm Uhlig’s research group is interested in the balance of the immune system that enables to fight gastrointestinal pathogens very effectively but tolerates commensal microbiota in the gut. Inflammatory bowel disease (IBD) can develop when this immune ballance in the gut is desturbed due to several mechanisms. Those include a breakdown in the epithelial barrier, inefficient killing of pathogenic or potentially pathogenic bacteria by phagocytes, as well as autoinflammatory defects and defective negative control of the innate and adaptive immune system by regulatory T cells. Dr Uhlig’s group investigates novel genetic defects that lead to very early onset intestinal inflammation using next generation sequencing as part of the Oxford IBD cohort study and the COLORS in IBD consortium (COLitis of early Onset - Rare diseaseS withIN IBD). The main aim of this consortium is to understand key functional immunological pathway that lead to inflammatory bowel disease. Email: [email protected] Further information is available at: http://www.ndm.ox.ac.uk/principal-investigators/researcher/holm-uhlig

Global Health The Department makes significant contribution to the Medical Sciences Division’s global health programme both through its strength in infectious disease, but also via strong links with the Oxford Tropical Network. Investigators working in Global Health with links to the Department of Paediatrics include Professor Dominic Kwiatowski (genetics and susceptibility to infection), Dr Jay Berkley (clinical epidemiology, Kilifi,

2 Kenya), Professor Mike English (health systems research, Nairobi, Kenya) and Professor Tom Williams (epidemiology of malaria and haemoglobinopathies, Kilifi, Kenya) while opportunities also exist for research in Nepal through the Oxford Vaccine Group (see below). Further information and contact details are available at: http://www.ndm.ox.ac.uk/principal-investigators

Haematology Professor Irene Roberts' group, based in the Weatherall Institute of Molecular Medicine and Department of Paediatrics, is carrying out clinical and translational research into the haematological problems of children with Down syndrome, including leukaemia. Her group has a particular interest in how trisomy 21 interferes with normal blood cell growth and differentiation and the mechanisms by which this leads to the increased susceptibility to leukaemia in these children. Laboratory studies use a combination of cellular and molecular techniques to address these questions. Clinical studies focus on haematological problems in the newborn period and the natural history of neonatal Transient Abnormal Myelopoiesis which evolves to acute leukaemia in 10-20% of cases. This work aims to identify factors which predict which neonates are at greatest risk of leukaemic transformation and devise strategies to reduce this risk. Email: [email protected] or via [email protected]

Immunology and Infectious Diseases Professor Philip Goulder is working to define mechanisms of immune control of HIV infection and exploring strategies to alter the natural course of infection in children. The Goulder Group studies cohorts of children and adults attending clinics in South Africa, in Durban, KwaZulu-Natal, and also in Kimberley, Northern Cape, in addition to smaller cohorts of HIV-infected study subjects attending clinics in the Thames Valley region in UK. The goal of this work is to define the immune responses that are effective in control of HIV, and that an effective HIV vaccine would need to induce. The particular interest of the group is in determining the nature of the vaccine, and the optimal timing of vaccination, that would address the rapidly growing number of children infected with HIV for whom the only option currently available is a lifetime on antiretroviral therapy starting from birth Email: [email protected] Further information is available at: http://www.paediatrics.ox.ac.uk/research/professor-philip-goulder

Professor Georg Holländer's research group studies the development and function of the adaptive immune system with a particular focus on delineating the molecular and cellular pathways that govern regular thymus organogenesis and function. The experimental work uses state-of-the art cellular and molecular methods as well as computational biological approaches to investigate wild type and gene targeted mouse models to interrogate the molecular mechanisms of health and specific immunodeficiencies. In parallel, other research activities focus on defining the genetic programmes that control the function of the human immune system. Several opportunities exist to learn molecular and cellular techniques of experimental immunology and to participate in the laboratory's research programme. Email: [email protected] Further information is available at: http://www.imm.ox.ac.uk/wimm-research/paediatrics/prof-georg-hollaender

3 Professor Andrew Pollard leads the Oxford Vaccine Group, based in the Centre for Clinical Vaccinology and Tropical Medicine. His research focuses on the design, development, clinical testing and laboratory evaluation of new and improved vaccines to improve public health. The applied immunology group studies the development of the B cell response using cellular, molecular and functional genomic approaches and a translational vaccinology programme has brought a Group B meningococcal vaccine to phase I trials. The group are developing a controlled human infection model of typhoid and paratyphoid to drive new approaches to prevention of enteric fever, of great relevance to the team’s field site in Nepal which studies bacterial infections in children and their vaccine prevention. Email: [email protected] Further information is available at: http://www.ovg.ox.ac.uk/

Neurosciences Dr Rebecca Slater is a Senior Lecturer within the Department of Paediatrics, a Wellcome Trust Career Development Fellow and Lecturer in Biomedical Science at Lady Margret Hall. Dr Slater leads the Paediatric and Infant Pain & Anaesthesia (PiPA) group, which focuses on understanding the development of human pain processing, with a particular focus on improving the treatment of infant pain. The group uses a range of non-invasive tools to explore the of development of pain in the human nervous system. The group is also investigating the long-term effects of prematurity and alterations in anaesthetic requirements in children born prematurely. Email: [email protected] Further information is available at: http://pipagroup.wordpress.com/about/

If trainees are interested in pursuing research in any of the above themes they should contact the academic leads of the themes as listed. Alternatively, they can contact Dr Matthew Snape, ACF programme coordinator ([email protected]), who will also be happy to discuss research opportunities in these and other areas. The Department has strong links with the Oxford University Hospitals NHS Trust Department of Paediatrics, which is co- located in the new Children’s Hospital. The candidate may also wish contact the relevant NHS consultant with their specialty interest, listed below, about clinical training opportunities in the Department.

Dr Eleri Adams Consultant Paediatrician (Neonatal Medicine) Dr Satish Adwani Consultant Paediatric Cardiologist Dr Tariq Ali Consultant Paediatric Intensive Care Dr Geetha Anand Consultant Paediatrician (General, Neurology) Dr Mark Anthony Consultant Paediatrician (Neonatal Medicine) Dr Nick Archer Consultant Paediatric Cardiologist Dr Charlotte Bennett Consultant Paediatrician (Neonatal Medicine) Dr Saleel Chandratre Consultant Paediatrician (Neurology) Dr Janet Craze Consultant Paediatrician (Renal & General) Dr Julie Edge Consultant Paediatrician (Diabetes) Dr Sri Gada Consultant Paediatrician (Community Child Health) Prof Philip Goulder* Hon. Consultant Paediatrician (Paediatric HIV disease) Dr Praveen Goyal Consultant Paediatrician (Community Child Health, General)

4 Mr Hugh Grant Consultant Paediatric Surgeon Dr Amit Gupta Consultant Paediatrician (Neonatal Medicine) Dr Georgina Hall Consultant Paediatric (Haematologist/Oncologist) Prof Georg Hollander Professor of Paediatrics Dr Jeremy Hull Consultant Paediatrician (Respiratory Medicine) Dr Andrew Ives Consultant Paediatrician (Respiratory Medicine) Dr Kevin Ives Consultant Paediatrician (Neonatal Medicine) Mr Paul Johnson* Clinical Reader & Hon Consultant in Paediatric Surgery Dr Sandeep Jayawant Consultant Paediatrician (Neurology) Mr Jay Jayamohan Consultant in Paediatric Neurosurgery Dr Dominic Kelly* Consultant Paediatrician (General and Academic) Prof Dominic Kwiatkowski* Hon Consultant Paediatrician (Tropical Paediatrics) Miss Kokila Lakhoo Consultant Paediatric Surgeon Mr Alex Lee Consultant Paediatric Surgeon Dr Ravi Lehal Consultant Paediatrician (General) Dr Tafy Makaya Consltant Paediatrician (Endocrine) Dr Kenny McCormick Consultant Paediatrician (Neonatal Medicine) Dr Tony McShane Consultant Paediatric Neurologist Dr Sheila Lane Consultant Paediatric Oncologist Dr Fran O’Brien Consultant Paediatrician (Neonatal Medicine) Dr Edwin Osakwe Consultant Paediatrician (General) Dr Mike Pike Consultant Paediatric Neurologist Prof Andrew Pollard* Hon Consultant Paediatrician (Infectious Diseases) Dr Amrana Quereshi Consultant Paediatric Haematologist Mr Peter Richards Consultant Paediatric Neurosurgeon Dr Clare Robertson Consultant Paediatrician (Community Child Health) Dr Astor Rodri gues Consultant Paediatrician (Gastroenterology) Dr Mandy Rose Consultant Paediatrician (Community Child Health) Dr Fiona Ryan Consultant Paediatrician (Endocrinology, Diabetes) Dr John Shaw Consultant Paediatrician (Community Child Health) Dr Alison Shefler Consultant Paediatric Intensivist Dr Matthew Snape* Consultant Paediatrician (General and Academic) Dr Peter Sullivan* Reader & Hon Consultant (Paediatric Gastroenterology) Dr Umasunthar Thisanayagam Consultant Paediatrician (General) Miss Silke Wagener Consultant Paediatric Surgeon Dr Kate Wheeler Consultant Paediatric Oncologist (and General) Dr Nick Wilkinson Consultant Paediatrician (Rheumatology) Dr Shaun Wilson Consultant Paediatrician (Oncology)

Teaching The Department is highly regarded within the Medical Sciences Division for its high quality undergraduate teaching. The undergraduate course and special study modules are under continual refinement and development as a result of an active programme of feedback and educational research. A variety of teaching opportunities are also available including opportunities to be involved in undergraduate medical student courses. In addition, there is the opportunity to undertake the Diploma in Learning and Teaching in Higher Education (DLATHE) at Oxford University.

Selection Criteria

5 The Academic Clinical Fellowship Programmes will offer training to enthusiastic entrants to paediatric and child health training who can demonstrate that they have outstanding potential for development as a clinical academic in research and/or education. Trainees can apply at ST1-3. Training will be flexible and trainee-centred, as far as possible, with mentoring to ensure the attainment of both academic and clinical goals. Trainees are encouraged to discuss their research interests with an appropriate academic supervisor prior to submitting their application, and certainly prior to interview if shortlisted. The trainee selected for the Fellowship Programme will be awarded an NTN(a) at the start of the Programme.

Training objectives

The main objectives of the programme will be to provide: an entry point for doctors aspiring to a research based career in Child Health as well as provide training in Paediatrics and Child Health competencies leading to GMC accreditation working with an academic supervisor to develop a project for a DPhil application during the ACF post

Structure of the training programme

These posts are designed to meet the needs of doctors at ST1-3 level who wish to pursue an academic career in paediatrics. 75% of the trainee’s time will be spent in clinical work, and 25% in academic work. They will be based in the Oxford region with academic time in Oxford. Clinical training would be overseen by Health Education Thames Valley and post holders will undergo an ARCP assessment on an annual basis to assess the quality of their training. Each Fellow will have a clinical, an educational and an academic (research/teaching) supervisor. The University Department of Paediatrics will normally provide the academic supervision but trainees may alternatively engage with academic supervisors from elsewhere in the Medical Sciences Division as appropriate to their clinical and research interests. The trainee will be placed in research units to gain sufficient experience for development of a research interest and planning of grant applications for a higher degree. Details of the academic programme will depend on the interests of the candidates. Clinical training will be according to the OxPaed training programme in the School of Paediatrics (see the School of Paediatrics website http://www.oxfordpaediatrics.com). Trainees will be expected to achieve the same competences as their full-time clinical colleagues, and will be involved in clinical service and training as well as teaching in any of the hospitals in Health Education Thames Valley according to an allocation process which will be the same as for other non-academic trainees. The trainee will be expected to complete the MRCPCH exams within the 36 months.

In addition to the clinical work, the trainee will be able to explore the range of research opportunities and projects offered in the various research units. This would allow time for informed selection of a research area and project towards a higher degree. At the end of the first year the trainee will be required to choose an area of research interest and develop a protocol for their research project for the next two years. The structure of the second and third years may include blocks of protected time free of clinical duties of 6 months to allow development of the research ideas. It is envisaged that by the end of the post the trainee will be successful in obtaining a research fellowship and pursue a DPhil. Regular appraisals will be undertaken to

6 monitor progress towards this goal and appropriate interventions will be initiated to ensure relevant career progression towards a CCT in Paediatrics.

For further details of the training programme please visit Health Education Thames Valley School of Paediatrics website http://www.oxfordpaediatrics.com/ For further information contact Dr Peter Sullivan 01865-234220 or Dr Matthew Snape ([email protected])

Main Conditions of Service Appointments to this programme are subject to the Terms and Conditions of Service (TCS) for Hospital Medical and Dental Staff (England and Wales). In addition appointments are subject to: Applicants having the right to work and be a doctor or dentist in training in the UK Registration with the General Medical Council Pre-employment checks carried out by the Trust HR department in line with the NHS employment check standards, including CRB checks and occupational health clearance.

The employing Trust’s offer of employment is expected to be on the following nationally agreed terms:

Hours – The working hours for junior doctors in training are now 48-hours (or 52- hours if working on a derogated rota) averaged over 26 weeks (six months). Doctors in training also have an individual right to opt-out if they choose to do so, but they cannot opt-out of rest break or leave requirements. However, the contracts for doctors in training make clear that overall hours must not exceed 56 hours in a week (New Deal Contract requirements) across all their employments and any locum work they do. http://www.nhsemployers.org/PlanningYourWorkforce/MedicalWorkforce/EWT D/Pages/EWTD.aspx

Pay – you should be paid monthly at the rates set out in the national terms and conditions of service for hospital medical and dental staff and doctors in public health medicine and the community health service (England and Wales), “the TCS”, as amended from time to time. The payscales are reviewed annually. Current rates of pay may be viewed at http://www.nhsemployers.org/PayAndContracts/Pay %20circulars/Pages/PayCircularsMedicalandDental.aspx Part time posts will be paid pro-rata

Pay supplement –depending upon the working pattern and hours of duty you are contracted to undertake by the employer you should be paid a monthly additional pay supplement at the rates set out in paragraph 22 of the TCS. The current payscales may be viewed at http://www.nhsemployers.org/PayAndContracts/Pay %20circulars/Pages/PayCircularsMedicalandDental.aspx . The pay supplement is not reckonable for NHS pension purposes. The pay supplement will be determined by the employer and should be made clear in their offer of employment and subject to monitoring.

Pension – you will be entitled to join or continue as a member of the NHS Pension Scheme, subject to its terms and rules, which may be amended from time to time. If you leave the programme for out of programme experience you may have a gap in

7 your pension contributions. More information can be found at http://www.nhsbsa.nhs.uk/pensions

Annual Leave – your entitlement to annual leave will be five or six weeks per annum depending on your previous service/incremental point, as set out in paragraphs 205- 206 of the TCS. The TCS may be viewed at http://www.nhsemployers.org/PayAndContracts/MedicalandDentalContracts/JuniorD octorsDentistsGPReg/Pages/DoctorsInTraining- JuniorDoctorsTermsAndConditions150908.aspx

Sick pay – entitlements are outlined in paragraph 225 of the TCS.

Notice –you will be required to give your employer and entitled to receive from them notice in accordance with paragraphs 195-196 of the TCS.

Study Leave –the employer is expected to offer study leave in accordance with paragraphs 250-254 of the TCS. Local policy and procedure will be explained at induction.

Travel Expenses – the employer is expected to offer travel expenses in accordance with paragraphs 277-308 of the TCS for journeys incurred in performing your duties. Local policy and procedure should be explained at induction.

Subsistence expenses – the employer is expected to offer subsistence expenses in accordance with paragraph 311 of the TCS. Local policy and procedure should be explained at induction.

Relocation expenses – the employer will have a local policy for relocation expenses based on paragraphs 314 – 315 of the TCS and national guidance at http://www.nhsemployers.org/PayAndContracts/MedicalandDentalContracts/JuniorD octorsDentistsGPReg/Pages/DoctorsInTraining- JuniorDoctorsTermsAndConditions150908.aspx You are advised to check eligibility and confirm any entitlement with the employer before incurring any expenditure.

Pre-employment checks – all NHS employers are required to undertake pre- employment checks. The employer will confirm their local arrangements, which are expected to be in line with national guidance at http://www.nhsemployers.org/RecruitmentAndRetention/Employment- checks/Pages/Employment-checks.aspx

Professional registration – it will be a requirement of employment that you have professional registration with the GMC/GDC for the duration of your employment. Though the post is covered by NHS Indemnity, you are strongly advised to register with the MPS for professional indemnity.

Health and Safety – all employers have a duty to protect their workers from harm. You should be advised by the employer of local policies and procedures intended to protect your health and safety and expected to comply with these.

8 Disciplinary and grievance procedures – the employer will have local policies and procedures for dealing with any disciplinary concerns or grievances you may have. They should advise you how to access these, not later than eight weeks after commencement of employment.

Educational Supervisor – the employer or a nominated deputy (usually the Director of Medical Education) will confirm your supervisor on commencement.

General information on the LETB’s management of Specialty Training programmes, including issues such as taking time out of programme and dealing with concerns or complaints, is available at www.oxforddeanery.nhs.uk and in the national ‘Gold guide’ to Specialty Training at http://www.mmc.nhs.uk Please ensure that you inform Health Education Thames Valley of any changes to your contact details.

October 2013