Supplementary Information Titles

Journal: Nature Medicine

Article Title: The NALP3/NLRP3 Inflammasome Instigates Obesity- Induced Autoinflammation and Insulin Resistance

Corresponding Vishwa Deep Dixit ([email protected]) Author:

Supplementary Item & Title or Caption Number

Supplementary Figure 1 Quantitation of caspase 1 activation. Supplementary Figure 2 Quantitation of IL-1β activation. Supplementary Figure 3 The GTT and ITT in WT and Nlrp3 knockout mice fed chow diet. Supplementary Figure 4 Body weight and blood lipid profile of WT and Nlrp3 knockout mice. Supplementary Figure 5 Quantitation of AKT, IRS and ERK activation in respone to insulin in obese WT and Nlrp3 knockout mice.

Supplementary Figure 6 Immunoblot analysis if AKT and ERK phosphorylation in respone to insulin in obese WT and Nlrp3 knockout mice.

Supplementary Table 1 Subject characteristics

Supplementary Methods