1) (1) Name: What Is the Name of the Disorder? Is It Commonly Known by Any Other Names?

Genetic Disorder Pamphlet

You will become an expert on a human genetic disorder by researching one genetically linked disease and preparing a tri-fold brochure about the disease, similar to one you would see in a doctor’s office. Start with http://www.genome.gov/11510197 for suggestions of online research resources. Your brochure should include the following: 1) (1) Name: What is the name of the disorder? Is it commonly known by any other names? 2) (5) Clinical description of the disorder: What are the characteristics and symptoms of the disorder? Who does it affect? Is it found more commonly in certain groups (ethnic, religious …)? Are there different forms and/or severities of the disease? 3) (3)Mode of inheritance: What is the genetic cause of the disorder? Causes could be: autosomal dominant, autosomal recessive, sex-linked, an X-linked recessive trait, a multi-factorial trait (polygenic disorder), or chromosomal error. Multi-factorial disorders are caused by several genes or by a combination of genetic and environmental factors (explain what these factors are for your disorder). Chromosomal errors may be of several types: missing a particular chromosome (ex: no X chromosome), having an extra chromosome (ex: extra chromosome 21), or having a damaged chromosome (part of a chromosome is deleted). 4) (3) Detection: Can the disorder be detected before the symptoms appear? Can it be detected prenatally or before birth? Is there a way to detect the carrier of the disorder? If so, how? 5) (5) Health Problems: What problems are associated with the disease throughout one’s lifespan (infant to adult)? Is the disorder physically limiting (explain the limits)? Is it life threatening (explain how and at what age to expect difficulties)? 6) (5) Treatment: What methods are currently available to manage this disease and its symptoms (medication, therapies, exercise, diet, etc. – be specific!)? 7) (4) At least 2 other interesting facts 8) (6) At least 3 visual aides (graphics, illustrations, pictures) Be sure to label and title your visual aides, if appropriate. 9) (6) Bibliography: Use and then cite a minimum of three sources/references you used while researching your pamphlet. You must use at least 2 websites (only .gov, .org, or .edu!) and at least one book. On the back of your pamphlet, you should cite your sources: For websites: Title of the Article, Author (If applicable). Website URL. Date Accessed. For books: Title of Article, Author (If applicable). Book Title. Publishing date and location, Pages used.

Remember: This brochure is intended for the general public. Try to stay away from confusing scientific terms. If you need to, feel free to give a short definition of a word or two, to help people understand. Also, it is not necessary to include large paragraphs of information! Bullet points with large titles are good for these types of media. Think of sitting in the doctor’s office and trying to learn about a disease you have just found out a person in your family has….. you don’t want to spend hours reading. A quick reference is a good thing.

This assignment will be worth 50 pts. 38 pts (1-9 above) 6 pts (Overall neatness, quality, attractiveness, etc) 6 pts (Daily work in class, 2 pts per day) Some websites that might be helpful as you look for information:

Medline http://www.nlm.nih.gov/medlineplus/geneticdisorders.html

Center for Disease Control http://www.cdc.gov/genomics/default.htm genetic and rare conditions http://www.kumc.edu/gec/support/ online mendelian inheritance in man- if you want to know the chromosome affected by a disease, this website will tell you (May be a bit complicated so ask for help if you need it.) http://www3.ncbi.nlm.nih.gov/Omim/ lots of info on genetic diseases/ disorders http://www.genome.gov/10001200

There is also another useful site listed on my website (www.msu.edu/~knothsar)

Your brochure can be typed or hand written, it’s up to you. We will be in the computer lab/library Tuesday, Wednesday, and Thursday. Pamphlets are due on Friday, April 27 (NO EXCEPTIONS! That means if you aren’t here on Thursday, your pamphlet is still due on Friday!!!)