UCSF Lab Standard Operating Procedure s6

UCSF Lab Standard Operating Procedure

Chemical Process, Name or Hazard Class: Nitroglycerin

Please fill out the form completely. Insure all users have access to this SOP. Refer to instructions for assistance. Department: Enter text. Date SOP was written: Enter date. This lab specific SOP has been reviewed and approved by: Principal Investigator Name: Enter text. Principal Investigator Signature Lab Manager/Supervisor: Enter text.

Type of SOP: ☐ Process ☒Hazardous Chemical ☐ Hazardous Class

Purpose

Nitroglycerin is a high explosive and is sensitive to heat, shock or friction. Is readily absorbed through the skin and can cause systemic effects.

Nitroglycerin has many uses including in explosives and in medicine used as a heart medication.

Nitroglycerin (NG) is also known as nitroglycerine, trinitroglycerin, trinitroglycerine, or as glyceryl trinitrate or 1,2,3-trinitroxypropane.

Physical & Chemical Properties/Definition of Chemical Group

CAS#: 55-63-0

Class: Explosive

Molecular Formula: C3H5N3O9

Form (physical state): liquid

Color: coloress

Boiling point: 50 °C (Explodes)

Nitroglycerin 1 Date: Click here to enter a date. Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/) Potential Hazards/Toxicity

Nitroglycerin is a high explosive and is sensitive to heat, shock or friction. Is readily absorbed through the skin and can cause systemic effects.

The following permissible exposure limit data is available: 0.2 ppm (2 mg/m3) skin

No acute toxicity data is available.

Engineering Controls

Handle using a chemical fume hood with good ventilation and electrically grounded lines and equipment

Personal Protective Equipment (PPE)

Respirator Protection If lab personnel would like to use respirator on a voluntary basis, they must be trained and fit-tested by EH&S. This is a regulatory requirement. (http://or.ucsf.edu/ehs/8193-DSY/version/default/part/4/data/)

Hand Protection Gloves must be worn. Use proper glove removal technique to avoid any skin contact. Nitrile gloves are recommended.

NOTE: Consult with your preferred glove manufacturer to ensure that the gloves you plan on using are compatible with Nitroglycerin

Refer to glove selection chart from the links below: http://www.ansellpro.com/download/Ansell_8thEditionChemicalResistanceGuide.pdf OR http://www.allsafetyproducts.biz/page/74172 OR http://www.showabestglove.com/site/default.aspx OR http://www.mapaglove.com/

Eye Protection ANSI approved, tight-fitting safety glasses/goggles. Face shield recommended.

Skin and Body Protection Flame resistant lab coats must be worn and be appropriately sized for the individual and buttoned to their full length. Laboratory coat sleeves must be of sufficient length to prevent skin exposure while wearing gloves. Full length pants and close-toed shoes must be worn at all times by all individuals that are occupying the laboratory area. The area of skin between the shoe and ankle should not be exposed.

Hygiene Measures

Nitroglycerin 2 Date: Click here to enter a date. Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/) Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

First Aid Procedures

If inhaled Remove immediately to fresh air. If not breathing, give artificial respiration. If breathing is difficult, provide oxygen. Seek medical aid immediately.

In case of skin contact Remove contaminated clothing as rapidly as possible. Flush affected skin with plenty of water and mild soap. Seek immediate medical attention.

In case of eye contact Persons with potential exposure should not wear contact lenses. Flush eyes with plenty of water for at least 30 minutes lifting lower and upper eyelids. Seek medical aid. Continue rinsing during transport to hospital.

If swallowed Do not induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Seek medical aid immediately.

Special Handling and Storage Requirements

Precautions for safe handling: Explosive, avoid heat, shock or friction. Avoid contact with skin and eyes and inhalation. Avoid inhalation of vapor or mist. Avoid formation of dust.

Conditions for safe storage: Explosive, avoid heat, shock or friction. Keep in a dry place. Keep container tightly closed in a cool, dry, and well ventilated. Keep away from incompatible materials and conditions. Keep cool and protect from sunlight. .

Spill and Accident Procedure Chemical Spill Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-206- 8522 (SFGH only)

Spill – Assess the extent of danger. Assist contaminated or injured persons. Evacuate the spill area. Avoid breathing vapors. If possible, confine the spill to a small area using a spill kit or absorbent material. Keep others from entering contaminated area (e.g., use caution tape, barriers, etc.).

Small (<1 L) – If you have training, you may assist in the clean-up effort. Use appropriate personal protective equipment and clean-up material for chemical spilled. Double bag spill waste in clear plastic bags, label and take to the next chemical waste pick-up.

Large (>1 L) – Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-206- 8522 (SFGH only) for assistance.

Nitroglycerin 3 Date: Click here to enter a date. Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/) Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency shower for at least 15 minutes. If discomfort persists, proceed to the Emergency Department. If no further discomfort is experienced, have the SDS ready and contact Poison Control Hotline at 1-800- 222-1222 for further exposure information. Notify your direct supervisor and EH&S at 415- 476-1300 during work hours, or 9-911 during non-working hours and weekends.

Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with water for 15 minutes by forcibly holding the eye open. If discomfort persists, proceed to the Emergency Department. If no further discomfort is experienced, have the SDS ready and contact Poison Control Hotline at 1-800-222-1222 for further exposure information. Notify your direct supervisor and EH&S at 415-476-1300 during work hours, or 9-911 during non-working hours and weekends.

Medical Emergency Dial 9-911 (campus phone) or 476-6911 (cell phone)

Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.

Non-Life Threatening Emergency– Go to Occupational Health Programs (OHP) Clinic, 415-885- 7580, 2330 Post Street, Suite 460 Hours of Operation for Appointments: Monday - Friday 7:30 a.m. - 4:00 p.m. (except Holidays).

Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.

Needle stick/puncture exposure (as applicable to chemical handling procedure) – Wash the affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane exposure, flush the affected area for 15 minutes using an eyewash station. Page the needle stick nurse by dialing 415-353-7842 (STIC).

Decontamination/Waste Disposal Procedure

Clean contaminated surfaces with soap and water and paper towels. Dispose of the paper towels as hazardous waste.

Safety Data Sheet (SDS) Location

Online SDS can be accessed at http://or.ucsf.edu/ehs/7241-DSY/msds.html

Protocol/Procedure

Quantities covered by this SOP: ______(g , ml) to ______(g, ml)

Temperature range covered by this SOP: __ °C – __ °C

General Overview and Purpose:

Nitroglycerin 4 Date: Click here to enter a date. Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/) Enter the experimental purpose

Procedure: Enter experimental procedure. You can copy procedure from your lab notebook or from literature.

Any deviation from this SOP requires approval from the Principal Investigator.

Nitroglycerin 5 Date: Click here to enter a date. Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)