2.) Name: Presenilin 1 (PS-1) (S182 protein). Assession: P97887 Origin: mteipaplsy fqnaqmseds hsssvrsqnd nqerqqhhdr qrldnpesis ngrpqsnftr qvieqdeeed eeltlkygak hvimlfvpvt lcmvvvvati ksvsfytrkd gqliytpfte dtetvgqral hsilnaaimi svivvmtill vvlykyrcyk vihawlivss llllfffsfi ylgevfktyn vavdyitval liwnfgvvgm iaihwkgplr lqqaylimis almalvfiky lpewtawlil avisvydlva vlcpkgplrm lvetaqerne tlfpaliyss tmvwlvnmae gdpeaqrrvp knpkystqgt ereetqdtgt gsddggfsee weaqrdshlg phrstpesra avqelsgsil tsedpeergv rlglgdfify svlvgkasat asgdwnttia cfvailiglc ltllllaifk kalpalpisi tfglifyfat dylvqpfmdq lafhqfyi

Variants A234S caused by number of transcripts of the PS-1 gene changed during brain development K381R caused by number of transcripts of the PS-1 gene changed during brain development

PBD code: 1KE2 1KE1 1KDZ 1KZY 1KZV 1NLU 1GA1 1GA4 1GA6 Chain identifiers: A Start position query: 274 Start position PDB protein: 4 End position query: 365 End position PDB protein: 99

PBD code: 1P22 Chain identifiers: A Start position query: 253 Start position PDB protein: 358 End position query: 313 End position PDB protein: 426

PBD code: 1IW7 1SMY Chain identifiers: D/N Start position query: 340 Start position PDB protein: 338 End position query: 397 End position PDB protein: 398

PBD code: 1KJ8 1KJ9 1KJI 1KJJ 1KJQ Chain identifiers: A/B Start position query: 329 Start position PDB protein: 221 End position query: 367 End position PDB protein: 259

PBD code: 1EYZ 1EZ1 Chain identifiers: A/B Start position query: 329 Start position PDB protein: 222 End position query: 267 End position PDB protein: 260

3.) Name: Presenilin 2 (PS-2) (STM-2) (E5-1) (AD3LP) (AD5). Assession: P49810 Origin:

1 mltfmasdse eevcdertsl msaesptprs cqegrqgped gentaqwrsq eneedgeedp 61 dryvcsgvpg rppgleeelt lkygakhvim lfvpvtlcmi vvvatiksvr fytekngqli 121 ytpftedtps vgqrllnsvl ntlimisviv vmtiflvvly kyrcykfihg wlimsslmll 181 flftyiylge vlktynvamd yptllltvwn fgavgmvcih wkgplvlqqa ylimisalma 241 lvfikylpew sawvilgais vydlvavlcp kgplrmlvet aqernepifp aliyssamvw 301 tvgmakldps sqgalqlpyd pemeedsyds fgepsypevf eppltgypge eleeeeergv 361 klglgdfify svlvgkaaat gsgdwnttla cfvailiglc ltllllavfk kalpalpisi 421 tfglifyfst dnlvrpfmdt lashqlyi

Variants: R62H caused by AD4 T122P caused by AD4 N141I caused by AD4 V148I cause by AD4 M239V caused by AD4

PBD code: 1Q1C Chain identifiers: A Start position query: 325 Start position PDB protein: 130 End position query: 360 End position PDB protein: 170

4.) Name: Presenilin 1 (PS-1) (S182 protein). Assession: P49769 Origin: 1 mteipaplsy fqnaqmseds hsssairsqn dsqerqqqhd rqrldnpepi sngrpqsnsr 61 qvveqdeeed eeltlkygak hvimlfvpvt lcmvvvvati ksvsfytrkd gqliytpfte 121 dtetvgqral hsilnaaimi svivimtill vvlykyrcyk vihawliiss llllfffsfi 181 ylgevfktyn vavdyvtval liwnfgvvgm iaihwkgplr lqqaylimis almalvfiky 241 lpewtawlil avisvydlva vlcpkgplrm lvetaqerne tlfpaliyss tmvwlvnmae 301 gdpeaqrrvp knpkyntqra eretqdsgsg nddggfseew eaqrdshlgp hrstpesraa 361 vqelsgsilt sedpeergvk lglgdfifys vlvgkasata sgdwnttiac fvailiglcl 421 tllllaifkk alpalpisit fglvfyfatd ylvqpfmdql afhqfyi

Variant: S9T caused by Strain SAM P8 D40E caused by Strain SAM P8 E67CM caused by Strain SAM P8 ER 321..322RRD caused by Strain SAM P8

PBD code: 1P22 Chain identifiers: A Start position query: 253 Start position PDB protein: 258 End position query: 313 End position PDB protein: 426

PBD code: 1SMY Chain identifiers: D/N Start position query: 300 Start position PDB protein: 300 End position query: 376 End position PDB protein: 375

5.) Name: Presenilin 1 (PS-1) (S182 protein). Assession: P49768 Origin: mtelpaplsy fqnaqmsedn hlsntvrsqn dnrerqehnd rrslghpepl sngrpqgnsr qvveqdeeed eeltlkygak hvimlfvpvt lcmvvvvati ksvsfytrkd gqliytlfte dtetvgqral hsilnaaimi svivvmtill vvlykyrcyk vihawliiss llllfffsfi ylgevfktyn vavdyitval liwnfgvvgm isihwkgplr lqqaylimis almalvfiky lpewtawlil avisvydlva vlcpkgplrm lvetaqerne tlfpaliyss tmvwlvnmae gdpeaqrrvs knskynaest eresqdtvae nddggfseew eaqrdshlgp hrstpesraa vqelsssila gedpeergvk lglgdfifys vlvgkasata sgdwnttiac fvailiglcl tllllaifkk alpalpisit fglvfyfatd ylvqpfmdql afhqfyi

Variants A79V caused by AD3 V82L caused by AD3 C92S caused by AD3 V96F caused by AD3 F105L caused by AD3 L113P caused by AD3 frontemporal dementia Y115C caused by AD3 T116N caused by AD3 P117L caused by AD3 E120D caused by AD3 E120K caused by AD3 R128G caused by AD3 N135D caused by AD3 M139I caused by AD3 M139K caused by AD3 M139T caused by AD3 M139V caused by AD3 I143F caused by AD3 I143T caused by AD3 M146I caused by AD3 M146L caused by AD3 M146V caused by AD3 T147I caused by AD3 H163R caused by AD3 H163Y caused by AD3 W165C caused by AD3 J166P caused by AD3 S169L caused by AD3 1169P caused by AD3 L171P caused by AD3 L173W caused by AD3 L174M caused by AD3 F205L caused by AD3 G206A caused by AD3 G209R caused by AD3 G209V caused by AD3 I213T caused by AD3 L219P caused by AD3 A231T caused by AD3 A231V caused by AD3 M233L caused by AD3 M233T caused by AD3 L235P caused by AD3 A246E caused by AD3 L250S caused by AD3 A260V caused by AD3 L262F caused by AD3 C263R caused by AD3 P264L caused by AD3 G266S caused by AD3 P267S caused by AD3 P267T caused by AD3 R269G caused by AD3 R269H caused by AD3 L271V caused by AD3 R278T caused by AD3 E280A caused by AD3 E280G caused by AD3 L282R caused by AD3 A285V caused by AD3 L286V caused by AD3 S289C caused by AD3 E318G caused by AD3 G378E caused by AD3 G384A caused by AD3 S390I caused by AD3 L392V caused by AD3 N405S caused by AD3 A409T caused by AD3 C410Y caused by AD3 A426P caused by AD3 P436Q caused by AD3 P436S caused by AD3

PBD code: 3LAD Chain identifiers: A/B Start position query: 277 Start position PDB protein: 346 End position query: 379 End position PDB protein: 445

PBD code: 1SMY 1IW7 Chain identifiers: D/N Start position query: 339 Start position PDB protein: 338 End position query: 376 End position PDB protein: 375 6.) Name: Apolipoprotein A-II precursor (Apo-AII). Assession: P09813 Origin: 1 mkllamvall vticslegal vkrqadgpdm qslftqyfqs mteygkdlve kaktseiqsq 61 vkayfekthe qltplvrsag tslvnffssl mnleekpapa ak

Variants: Defects in Apoa2 are the cause of senescence accelerated mouse (SAM), the senile amyloid is a mutated apolipoprotein A-II. P28Q causes SAM E43D Causes IN STRAINS C57BL/6J AND DBA/2J L48F causes PCR V49M causes IN STRAINS C57BL/6J AND DBA/2J V61A causes IN STRAINS C57BL/6J AND DBA/2J

PBD code: 1L6L Chain identifiers: A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/S/T/U/V/W/X/Y/Z/1/2/3/4/5/6/7/8 Start position query: 24 Start position PDB protein: 1 End position query: 98 End position PDB protein: 75

PBD code: 1L6K Chain identifiers: A/B/C/D/E/F/G/H/I/J/K/L Start position query: 24 Start position PDB protein: 1 End position query: 98 End position PDB protein: 75

7.) Name: Microtubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). Assession: P10636 Origin:

maeprqefev medhagtygl gdrkdqggyt mhqdqegdtd aglkesplqt ptedgseepg setsdakstp taedvtaplv degapgkqaa aqphteipeg ttaeeagigd tpsledeaag hvtqepesgk vvqegflrep gppglshqlm sgmpgapllp egpreatrqp sgtgpedteg grhapellkh qllgdlhqeg pplkgaggke rpgskeevde drdvdesspq dsppskaspa qdgrppqtaa reatsipgfp aegaiplpvd flskvsteip asepdgpsvg rakgqdaple ftfhveitpn vqkeqahsee hlgraafpga pgegpeargp slgedtkead lpepsekqpa aaprgkpvsr vpqlkarmvs kskdgtgsdd kkaktstrss aktlknrpcl spklptpgss dpliqpsspa vcpeppsspk hvssvtsrtg ssgakemklk gadgktkiat prgaappgqk gqanatripa ktppapktpp ssgeppksgd rsgysspgsp gtpgsrsrtp slptpptrep kkvavvrtpp kspssaksrl qtapvpmpdl knvkskigst enlkhqpggg kvqiinkkld lsnvqskcgs kdnikhvpgg gsvqivykpv dlskvtskcg slgnihhkpg ggqvevksek ldfkdrvqsk igsldnithv pgggnkkiet hkltfrenak aktdhgaeiv ykspvvsgdt sprhlsnvss tgsidmvdsp qlatladevs aslakqgl

Vatriants: G258N caused by FTDP17 V289A caused by FTDP17 V442Y caused by FTDP17 S447P caused by FTDP17 K574T caused by FTDP17 G589V caused by FTDP17 P618L caused by FTDP17 P618S caused by FTDP17 S622N caused by FTDP17 V654M caused by FTDP17 R723W caused by FTDP17

8.) Name: ubiquitin-activating enzyme E1C isoform 1; Nedd8-activating enzyme hUba3 [Homo sapiens]. Assession: NP_003959 Origin: 1 madgeepekk rrrieellae kmavdggcgd tgdwegrwnh vkkflersgp fthpdfepst 61 eslqflldtc kvlvigaggl gcellknlal sgfrqihvid mdtidvsnln rqflfrpkdi 121 grpkaevaae flndrvpncn vvphfnkiqd fndtfyrqfh iivcgldsii arrwingmli 181 sllnyedgvl dpssivplid ggtegfkgna rvilpgmtac iectlelypp qvnfpmctia 241 smprlpehci eyvrmlqwpk eqpfgegvpl dgddpehiqw ifqksleras qynirgvtyr 301 ltqgvvkrii pavastnavi aavcatevfk iatsayipln nylvfndvdg lytytfeaer 361 kencpacsql pqniqfspsa klqevldylt nsaslqmksp aitatlegkn rtlylqsvts 421 ieertrpnls ktlkelglvd gqelavadvt tpqtvlfklh fts

Variants: M255V causes unknown

PBD code: 1NGV Chain identifiers: B/D Start position query: 22 Start position PBD code: 1 End position query: 463 End position PBD code: 442

9.) Name: Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP). Assession: P37840 Origin: mdvfmkglsk akegvvaaae ktkqgvaeaa gktkegvlyv gsktkegvvh gvatvaektk eqvtnvggav vtgvtavaqk tvegagsiaa atgfvkkdql gkneegapqe giledmpvdp dneayempse egyqdyepea

Variant: A30P in PARK1 A53T in PARK1

10.) Name: Gelsolin precursor, plasma (Actin-depolymerizing factor) (ADF) (Brevin) (AGEL). Assession: P06396 Origin: maphrpapal lcalslalca lslpvraata srgasqagap qgrvpearpn smvvehpefl kagkepglqi wrvekfdlvp vptnlygdff tgdayvilkt vqlrngnlqy dlhywlgnec sqdesgaaai ftvqlddyln gravqhrevq gfesatflgy fksglkykkg gvasgfkhvv pnevvvqrlf qvkgrrvvra tevpvswesf nngdcfildl gnnihqwcgs nsnryerlka tqvskgirdn ersgrarvhv seegtepeam lqvlgpkpal pagtedtake daanrklakl ykvsngagtm svslvadenp faqgalksed cfildhgkdg kifvwkgkqa nteerkaalk tasdfitkmd ypkqtqvsvl peggetplfk qffknwrdpd qtdglglsyl sshianverv pfdaatlhts tamaaqhgmd ddgtgqkqiw riegsnkvpv dpatygqfyg gdsyiilyny rhggrqgqii ynwqgaqstq devaasailt aqldeelggt pvqsrvvqgk epahlmslfg gkpmiiykgg tsreggqtap astrlfqvra nsagatrave vlpkagalns ndafvlktps aaylwvgtga seaektgaqe llrvlraqpv qvaegsepdg fwealggkaa yrtsprlkdk kmdahpprlf acsnkigrfv ieevpgelmq edlatddvml ldtwdqvfvw vgkdsqeeek tealtsakry ietdpanrdr rtpitvvkqg feppsfvgwf lgwdddywsv dpldramael aa

Variants D214N in FAF D214Y in FAF

14.) Name: integrin alpha X precursor; leukocyte surface antigen p150,95, alpha subunit; leu M5, alpha subunit; myeloid membrane antigen, alpha subunit [Homo sapiens] Assession: NP_000878 Origin: 1 mtrtraalll ftalatslgf nldteeltaf rvdsagfgds vvqyanswvv vgapqkitaa 61 nqtgglyqcg ystgacepig lqvppeavnm slglslastt spsqllacgp tvhhecgrnm 121 yltglcfllg ptqltqrlpv srqecprqeq divflidgsg sissrnfatm mnfvravisq 181 fqrpstqfsl mqfsnkfqth ftfeefrrss nplsllasvh qlqgftytat aiqnvvhrlf 241 hasygarrda akilivitdg kkegdsldyk dvipmadaag iiryaigvgl afqnrnswke 301 lndiaskpsq ehifkvedfd alkdiqnqlk ekifaiegte ttssssfele maqegfsavf 361 tpdgpvlgav gsftwsggaf lyppnmsptf inmsqenvdm rdsylgyste lalwkgvqsl 421 vlgapryqht gkaviftqvs rqwrmkaevt gtqigsyfga slcsvdvdsd gstdlvliga 481 phyyeqtrgg qvsvcplprg wrrwwcdavl ygeqghpwgr fgaaltvlgd vngdkltdvv 541 igapgeeenr gavylfhgvl gpsispshsq riagsqlssr lqyfgqalsg gqdltqdglv 601 dlavgargqv lllrtrpvlw vgvsmqfipa eiprsafecr eqvvseqtlv qsniclyidk 661 rsknllgsrd lqssvtldla ldpgrlspra tfqetknrsl srvrvlglka hcenfnlllp 721 scvedsvtpi tlrlnftlvg kpllafrnlr pmlaadaqry ftaslpfekn cgadhicqdn 781 lgisfsfpgl ksllvgsnle lnaevmvwnd gedsygttit fshpaglsyr yvaegqkqgq 841 lrslhltcds apvgsqgtws tscrinhlif rggaqitfla tfdvspkavl gdrllltanv 901 ssenntprts kttfqlelpv kyavytvvss heqftkylnf seseekeshv amhryqvnnl 961 gqrdlpvsin fwvpvelnqe avwmdvevsh pqnpslrcss ekiappasdf lahiqknpvl 1021 dcsiagclrf rcdvpsfsvq eeldftlkgn lsfgwvrqil qkkvsvvsva eitfdtsvys 1081 qlpgqeafmr aqtttvleky kvhnptpliv gssiggllll alitavlykv gffkrqykem 1141 meeangqiap engtqtpspp sek

Variants R48W caused by The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles

PBD code: 1N3Y Chain identifiers: A Start position query: 147 Start psotion PBD code: 7 End position query: 338 End position PBD code: 198

PBD code: 1NA5 1MF7 Chain identifiers: A Start position query: 145 Start psotion PBD code: 1 End position query: 336 End position PBD code: 192

PBD code: 1JLM Chain identifiers: Start position query: 145 Start psotion PBD code: 2 End position query: 335 End position PBD code: 192

PBD code: 1IDN 1BHO 1BHQ Chain identifiers: 1/2 Start position query: 151 Start psotion PBD code: 3 End position query: 338 End position PBD code: 190

PBD code: 1NAZ Chain identifiers: A Start position query: 146 Start psotion PBD code: 2 End position query: 336 End position PBD code: 192

PBD code: 1M1U Chain identifiers: A Start position query: 146 Start psotion PBD code: 9 End position query: 332 End position PBD code: 195

PBD code: 1IDO Chain identifiers: Start position query: 145 Start psotion PBD code: 2 End position query: 332 End position PBD code: 192

PBD code: 1JV2 1LSG 1MX1 Chain identifiers: A Start position query: 353 Start psotion PBD code: 156 End position query: 1095 End position PBD code: 949

PBD code: 1ZON Chain identifiers: Start position query: 145 Start psotion PBD code: 1 End position query: 338 End position PBD code: 187 PBD code: 1LFA 1ZOO 1ZOP Chain identifiers: A/B Start position query: 145 Start psotion PBD code: 1 End position query: 338 End position PBD code: 187

PBD code: 1RD4 Chain identifiers: A/B/C/D Start position query: 145 Start psotion PBD code: 5 End position query: 338 End position PBD code: 191

PBD code: 1DGQ Chain identifiers: A Start position query: 151 Start psotion PBD code: 8 End position query: 338 End position PBD code: 188

PBD code: 1CQP Chain identifiers: A/B Start position query: 151 Start psotion PBD code: 4 End position query: 336 End position PBD code: 182

PBD code: 1MQP 1MQA Chain identifiers: A Start position query: 151 Start psotion PBD code: 5 End position query: 333 End position PBD code: 180

PBD code: 1MJN Chain identifiers: A Start position query: 151 Start psotion PBD code: 4 End position query: 333 End position PBD code: 179

PBD code: 1MQ8 Chain identifiers: B/D Start position query: 151 Start psotion PBD code: 2 End position query: 333 End position PBD code: 177

PBD code: 1AOX Chain identifiers: A/B Start position query: 142 Start psotion PBD code: 1 End position query: 338 End position PBD code: 201

PBD code: 1PT6 Chain identifiers: A/B Start position query: 144 Start psotion PBD code: 3 End position query: 344 End position PBD code: 207

PBD code: 1CK4 Chain identifiers: A/B Start position query: 151 Start psotion PBD code: 6 End position query: 337 End position PBD code: 197

PBD code:1MHP Chain identifiers: A/B Start position query: 151 Start psotion PBD code: 4 End position query: 334 End position PBD code: 192

PBD code: 1QCY Chain identifiers: A Start position query: 151 Start psotion PBD code: 4 End position query: 335 End position PBD code: 193

PBD code: 1QCY Chain identifiers: A/B Start position query: 151 Start psotion PBD code: 5 End position query: 333 End position PBD code: 192

PBD code: 1DZI Chain identifiers: A Start position query: 151 Start psotion PBD code: 4 End position query: 322 End position PBD code: 180

PBD code: 1AOB Chain identifiers: A/B Start position query: 148 Start psotion PBD code: 3 End position query: 333 End position PBD code: 186

PBD code: 1ATZ Chain identifiers: A/B Start position query: 148 Start psotion PBD code: 4 End position query: 333 End position PBD code: 187

PBD code: 1SHT 1SHU Chain identifiers: X Start position query: 147 Start psotion PBD code: 4 End position query: 329 End position PBD code: 177

PBD code: 1FE8 Chain identifiers: A/B/C Start position query: 148 Start psotion PBD code: 10 End position query: 333 End position PBD code: 193

PBD code: 1QOP Chain identifiers: A Start position query: 146 Start psotion PBD code: 12 End position query: 329 End position PBD code: 215

PBD code: 1MJS Chain identifiers: A Start position query: 926 Start psotion PBD code: 1557 End position query: 1000 End position PBD code: 195

PBD code:1MK2 Chain identifiers: A Start position query: 962 Start psotion PBD code: 166 End position query: 1000 End position PBD code: 204

PBD code: 1M10 Chain identifiers: A Start position query: 151 Start psotion PBD code: 17 End position query: 329 End position PBD code: 193

PBD code: 1KHX Chain identifiers: A Start position query: 962 Start psotion PBD code: 187 End position query: 999 End position PBD code: 224 PBD code: 1HC3 Chain identifiers: A Start position query: 1020 Start psotion PBD code: 102 End position query: 1085 End position PBD code: 172

PBD code: 1MQS Chain identifiers: A Start position query: 311 Start psotion PBD code: 479 End position query: 436 End position PBD code: 614

PBD code: 1MX3 Chain identifiers: A Start position query: 1020 Start psotion PBD code: 99 End position query: 1085 End position PBD code: 169

PBD code: 1HKU Chain identifiers: A Start position query: 1020 Start psotion PBD code: 102 End position query: 1085 End position PBD code: 172

PBD code: 1OAK Chain identifiers: A Start position query: 151 Start psotion PBD code: 8 End position query: 329 End position PBD code: 184

PBD code: 1AJ8 Chain identifiers: A/B Start position query: 886 Start psotion PBD code: 89 End position query: 958 End position PBD code: 161

PBD code: 1VCA Chain identifiers: A/B Start position query: 1006 Start psotion PBD code: 7 End position query: 1052 End position PBD code: 48

PBD code:1SQO Chain identifiers: A Start position query: 151 Start psotion PBD code: 18 End position query: 329 End position PBD code: 159 PBD code: 1UEX Chain identifiers: C Start position query: 151 Start psotion PBD code: 18 End position query: 329 End position PBD code: 194

PBD code: 1L67 Chain identifiers:A Start position query: 642 Start psotion PBD code: 151 End position query: 691 End position PBD code: 210

PBD code: 1AUQ Chain identifiers: Start position query: 151 Start psotion PBD code: 17 End position query: 329 End position PBD code: 193

PBD code: 1LGR Chain identifiers: Start position queRy: 924 Start psotion PBD code: 5 End position query: 958 End position PBD code: 39

PBD code: 2LGS Chain identifiers: A Start position query: 324 Start psotion PBD code: 5 End position query: 958 End position PBD code: 39

PBD code: 1F52 1F1H 1FPY Chain identifiers: A/B/C/D/E/F/G/H/I/J/K/L Start position query: 924 Start psotion PBD code: 5 End position query: 958 End position PBD code: 39

PBD code: 2GLS Chain identifiers: A/B/C/D/E/F/G/H/I/J/K/L Start position query: 924 Start psotion PBD code: 6 End position query: 958 End position PBD code: 40

PBD code: 1IJB 1IJK Chain identifiers: A Start position query: 151 Start psotion PBD code: 15 End position query: 329 End position PBD code: 191

PBD code: 1G73 Chain identifiers: A/B Start position query: 886 Start psotion PBD code: 10 End position query: 947 End position PBD code: 75

PBD code: 1FNS Chain identifiers: A Start position query: 151 Start psotion PBD code: 8 End position query: 329 End position PBD code: 184

16.) Name: hepatocyte growth factor precursor; scatter factor; lung fibroblast-derived mitogen; hepatopoietin A [Homo sapiens] Assession: NP_000592 Origin: 1 mwvtkllpal llqhvllhll llpiaipyae gqrkrrntih efkksakttl ikidpalkik 61 tkkvntadqc anrctrnkgl pftckafvfd karkqclwfp fnsmssgvkk efghefdlye 121 nkdyirncii gkgrsykgtv sitksgikcq pwssmipheh sflpssyrgk dlqenycrnp 181 rgeeggpwcf tsnpevryev cdipqcseve cmtcngesyr glmdhtesgk icqrwdhqtp 241 hrhkflpery pdkgfddnyc rnpdgqprpw cytldphtrw eycaiktcad ntmndtdvpl 301 etteciqgqg egyrgtvnti wngipcqrwd sqyphehdmt penfkckdlr enycrnpdgs 361 espwcfttdp nirvgycsqi pncdmshgqd cyrgngknym gnlsqtrsgl tcsmwdknme 421 dlhrhifwep dasklnenyc rnpdddahgp wcytgnplip wdycpisrce gdttptivnl 481 dhpviscakt kqlrvvngip trtnigwmvs lryrnkhicg gslikeswvl tarqcfpsrd 541 lkdyeawlgi hdvhgrgdek ckqvlnvsql vygpegsdlv lmklarpavl ddfvstidlp 601 nygctipekt scsvygwgyt glinydgllr vahlyimgne kcsqhhrgkv tlneseicag 661 aekigsgpce gdyggplvce qhkmrmvlgv ivpgrgcaip nrpgifvrva yyakwihkii 721 ltykvpqs

Variations K304E caused by new crystal form of the NK1 splice variant of HGF/SF Y330D caused by new crystal form of the NK1 splice variant of HGF/SF *364W caused by new crystal form of the NK1 splice variant of HGF/SF

PBD code: 1SHY Chain identifiers: A Start position query: 495 Start psotion PBD code: 1 End position query: 728 End position PBD code: 234

PBD code: 1NK1 1GMN Chain identifiers: A/B Start position query: 28 Start psotion PBD code: 1 End position query: 210 End position PBD code: 183

PBD code: 1GMO Chain identifiers: A/B/C/D/E/F/G/H/I/J/K/L/M Start position query: 28 Start psotion PBD code: 1 End position query: 210 End position PBD code: 183

PBD code: 1BHT Chain identifiers: A/B Start position query: 35 Start psotion PBD code: 1 End position query: 210 End position PBD code: 176

PBD code: 1GP9 Chain identifiers: A/B/C/D Start position query: 36 Start psotion PBD code: 6 End position query: 210 End position PBD code: 177

PBD code: 1KIO Chain identifiers: A Start position query: 125 Start psotion PBD code: 1 End position query: 383 End position PBD code: 253

PBD code: 2HGF Chain identifiers: 31 Start position query: 1 Start psotion PBD code: 127 End position query: 97 End position PBD code:

PBD code: 1QRZ Chain identifiers: A/B/C/D Start position query: 507 Start psotion PBD code: 30 End position query: 720 End position PBD code: 243

PBD code: 1BUI 1BMK Chain identifiers: A/B Start position query: 507 Start psotion PBD code: 34 End position query: 720 End position PBD code: 247

PBD code: 1L4Z Chain identifiers: A Start position query: 507 Start psotion PBD code: 32 End position query: 720 End position PBD code: 247

PBD code: 1DDJ Chain identifiers: A/B/C/D Start position query: 507 Start psotion PBD code: 31 End position query: 720 End position PBD code: 244

PBD code: 1LAD Chain identifiers: A Start position query: 507 Start psotion PBD code: 33 End position query: 720 End position PBD code: 246

PBD code: 1RJX Chain identifiers: B Start position query: 507 Start psotion PBD code: 31 End position query: 720 End position PBD code: 234

PBD code: 1EKB Chain identifiers: B Start position query: 507 Start psotion PBD code: 14 End position query: 720 End position PBD code: 234

PBD code: 1AOL 1LTO Chain identifiers: A/B/C/D Start position query: 502 Start psotion PBD code: 9 End position query: 720 End position PBD code: 241

PBD code: 1LSW 1SLX 1SLV 1SLU Chain identifiers: B Start position query: 495 Start psotion PBD code: 1 End position query: 720 End position PBD code: 220

PBD code: 1AOJ Chain identifiers: A/B/C/D Start position query: 495 Start psotion PBD code: 1 End position query: 716 End position PBD code: 216

PBD code: 1GVL Chain identifiers: A Start position query: 494 Start psotion PBD code: 1 End position query: 720 End position PBD code: 221

PBD code: 1MLT 1QQU 1FMG 1FN6 1FNI 1L2E 1LO6 Chain identifiers: A Start position query: 495 Start psotion PBD code: 1 End position query: 720 End position PBD code: 220

PBD code: 1CO7 Chain identifiers: E Start position query: 494 Start psotion PBD code: 22 End position query: 720 End position PBD code: 220

PBD code: 3TGJ Chain identifiers: E Start position query: 494 Start psotion PBD code: 10 End position query: 720 End position PBD code: 230

PBD code: 2TBS Chain identifiers: Start position query: 517 Start psotion PBD code: 23 End position query: 723 End position PBD code: 222

PBD code: 1AMH Chain identifiers: A/B Start position query: 495 Start psotion PBD code: 1 End position query: 720 End position PBD code: 220

PBD code: 1EZS 1EZU Chain identifiers: C/D Start position query: 495 Start psotion PBD code: 1 End position query: 720 End position PBD code: 220

PBD code: 1ANB 1AND 1ANC 1DPO 1ANE 1BRA Chain identifiers: Start position query: 495 Start psotion PBD code: 1 End position query: 720 End position PBD code: 220

PBD code: 3TGI 1BRB 1BRC 1K90 1AN1 Chain identifiers: E Start position query: 495 Start psotion PBD code: 1 End position query: 720 End position PBD code: 220

PBD code: 1QL9 1J14 1AVW 1AVX 1EJA 1ROT 1S5S 1S6F 1S6H 1S81 1S82 1S83 1S84 S185 1C9P Chain identifiers: A Start position query: 495 Start psotion PBD code: 1 End position query: 720 End position PBD code: 220

PBD code: 1TFX 1TRN Chain identifiers: A/B Start position query: 495 Start psotion PBD code: 1 End position query: 720 End position PBD code: 220

PBD code: 1LDT Chain identifiers: T Start position query: 495 Start psotion PBD code: 1 End position query: 720 End position PBD code: 220

PBD code: 1F7Z Chain identifiers: A Start position query: 495 Start psotion PBD code: 1 End position query: 720 End position PBD code: 230

PBD code: 1UTJ 1UTK 1UTM Chain identifiers: A Start position query: 517 Start psotion PBD code: 43 End position query: 723 End position PBD code: 242

PBD code: 1UTL Chain identifiers: M Start position query: 517 Start psotion PBD code: 43 End position query: 723 End position PBD code: 242

PBD code: 1BZX 2STA 2STB Chain identifiers: E Start position query: 517 Start psotion PBD code: 23 End position query: 723 End position PBD code: 222

PBD code: 1F5R Chain identifiers: A Start position query: 504 Start psotion PBD code: 19 End position query: 723 End position PBD code: 228

PBD code: 1BIT Chain identifiers: Start position query: 517 Start psotion PBD code: 38 End position query: 723 End position PBD code: 237

PBD code: 1HJ8 Chain identifiers: A Start position query: 517 Start psotion PBD code: 23 End position query: 723 End position PBD code: 222

PBD code: 1FY8 1TGK Chain identifiers: E Start position query: 504 Start psotion PBD code: 19 End position query: 720 End position PBD code: 228

PBD code: 1TRM Chain identifiers: A/B Start position query: 495 Start psotion PBD code: 1 End position query: 720 End position PBD code: 220

PBD code: 2TRM Chain identifiers: Start position query: 495 Start psotion PBD code: 1 End position query: 720 End position PBD code: 220

PBD code: 1MBQ Chain identifiers: A Start position query: 517 Start psotion PBD code: 23 End position query: 716 End position PBD code: 215

17.) Name: hepatocyte growth factor activator inhibitor 1 isoform 1 precursor; hepatocyte growth factor activator inhibitor 1; Kunitz-type protease inhibitor 1 [Homo sapiens] Assession: NP_857593 Origin: 1 mapartmara rlapagipav alwllctlgl qgtqagpppa ppglpagadc lnsftagvpg 61 fvldtnasvs ngatflespt vrrgwdcvra ccttqncnla lvelqpdrge daiaacflin 121 clyeqnfvck fapregfiny ltrevyrsyr qlrtqgfggs gipkawagid lkvqpqeplv 181 lkdventdwr llrgdtdvrv erkdpnqvel wglkegtylf qltvtssdhp edtanvtvtv 241 lstkqtedyc lasnkvgrcr gsfprwyydp teqicksfvy ggclgnknny lreeecilac 301 rgvqggplrg ssgaqatfpq gpsmerrhpv csgtcqptqf rcsngccids flecddtpnc 361 pdasdeaace kytsgfdelq rihfpsdkgh cvdlpdtglc kesiprwyyn pfsehcarft 421 yggcygnknn feeeqqcles crgiskkdvf glrreipips tgsvemavav flvicivvvv 481 ailgycffkn qrkdfhghhh hppptpasst vsttedtehl vynhttrpl

Variants P45S also known as HAI-1B, encodes the longer isoform (1) Y123C also known as HAI-1B, encodes the longer isoform (1) R142T also known as HAI-1B, encodes the longer isoform (1) P337L also known as HAI-1B, encodes the longer isoform (1)

PBD code: 1BIK Chain identifiers: Start position query: 240 Start psotion PBD code: 16 End position query: 366 End position PBD code: 140 PBD code: 1SHP Chain identifiers: Start position query: 256 Start psotion PBD code: 3 End position query: 301 End position PBD code: 54

PBD code: 1LAO Chain identifiers: D/I Start position query: 391 Start psotion PBD code: 3 End position query: 441 End position PBD code: 53

PBD code: 1BRI Chain identifiers: I Start position query: 391 Start psotion PBD code: 5 End position query: 441 End position PBD code: 55

PBD code: 1KNT 2KNT 1KUN Chain identifiers: A Start position query: 396 Start psotion PBD code: 10 End position query: 441 End position PBD code: 55

PBD code: 1KTH Chain identifiers: A Start position query: 396 Start psotion PBD code: 10 End position query: 441 End position PBD code: 55

PBD code: 1AAP Chain identifiers: A/B Start position query: 391 Start psotion PBD code: 5 End position query: 441 End position PBD code: 55

PBD code: 1TAW Chain identifiers: B Start position query: 391 Start psotion PBD code: 5 End position query: 441 End position PBD code: 55

PBD code: 1JC6 Chain identifiers: A Start position query: 391 Start psotion PBD code: 7 End position query: 441 End position PBD code: 57

PBD code: 1IRH Chain identifiers: A Start position query: 391 Start psotion PBD code: 8 End position query: 442 End position PBD code: 59

PBD code: 1C07 Chain identifiers: I Start position query: 223 Start psotion PBD code: 17 End position query: 305 End position PBD code: 94

PBD code: 1ADZ Chain identifiers: Start position query: 396 Start psotion PBD code: 19 End position query: 441 End position PBD code: 64

PBD code: 1TFZ Chain identifiers: C/D Start position query: 396 Start psotion PBD code: 10 End position query: 441 End position PBD code: 55

PBD code: 1UUA Chain identifiers: A Start position query: 391 Start psotion PBD code: 3 End position query: 443 End position PBD code: 55

PBD code: 2TPI Chain identifiers: I Start position query: 391 Start psotion PBD code: 6 End position query: 443 End position PBD code: 58

PDB code: 3TGI 3TGH 3FSR 3F7Z 3TGK Chain idenitifiers: I Start position query: 391 Start position PDB code: 5 End position query: 443 End position PDB code: 57 PDB code: 1TPA 2KAI 2PTC 2TGP 3PTI 3BTK 1FY8 1BZX Chain idenitifiers: I Start position query: 391 Start position PDB code: 5 End position query: 302 End position PDB code: 57

PDB code: 4PTI 5PTI 6PTI 9PTI 1BPI Chain idenitifiers: Start position query: 391 Start position PDB code: 5 End position query: 302 End position PDB code: 57

PDB code: 1MTN Chain idenitifiers: D/H Start position query: 391 Start position PDB code: 5 End position query: 302 End position PDB code: 57

PDB code: 1CBW Chain idenitifiers: D/I Start position query: 391 Start position PDB code: 5 End position query: 302 End position PDB code: 57

PDB code: 1BTH Chain idenitifiers: P/Q Start position query: 391 Start position PDB code: 5 End position query: 302 End position PDB code: 57

PDB code: 2HEX 1BOC 1BZ5 Chain idenitifiers: A/B/C/D/E Start position query: 391 Start position PDB code: 5 End position query: 302 End position PDB code: 57

PDB code: 1BHC Chain idenitifiers: A/B/C/D/E/F/G/H/I/J Start position query: 391 Start position PDB code: 5 End position query: 302 End position PDB code: 57

PDB code: 1DOB Chain idenitifiers: B Start position query: 391 Start position PDB code: 5 End position query: 302 End position PDB code: 57

PDB code: 1EAW Chain idenitifIers: B/D Start position query: 391 Start position PDB code: 5 End position query: 302 End position PDB code: 57

PDB code: 1PIT Chain idenitifiers: Start position query: 391 Start position PDB code: 5 End position query: 443 End position PDB code: 57

PDB code: 1OA5 1OA6 Chain idenitifiers: 5 Start position query: 391 Start position PDB code: 5 End position query: 443 End position PDB code: 57

PDB code: 1QLQ 1G6X 1K6U Chain idenitifiers: A Start position query: 248 Start position PDB code: 3 End position query: 302 End position PDB code: 57

PDB code: 4TPI Chain idenitifiers: I Start position query: 248 Start position PDB code: 3 End position query: 302 End position PDB code: 57 PDB code: 3BTQ 3BTE 2BTT 3BTM 3BTH 3BTD 1P2K 1P2J 3BTG 1P2I 3PTW 3BTF Chain idenitifiers: I Start position query: 391 Start position PDB code: 5 End position query: 443 End position PDB code: 57

PDB code: 1P2O 1P2N 1P2M 1P2Q Chain idenitifiers: B/D Start position query: 391 Start position PDB code: 5 End position query: 443 End position PDB code: 57

PDB code: 1BTI 1FAN 1NAG 1BPT 9PTI Chain idenitifiers: Start position query: 391 Start position PDB code: 5 End position query: 493 End position PDB code: 57

PDB code: 1JV8 1JV9 Chain idenitifiers: A Start position query: 391 Start position PDB code: 5 End position query: 443 End position PDB code: 57

PDB code: 1LD6 Chain idenitifiers: A Start position query: 243 Start position PDB code: 3 End position query: 302 End position PDB code: 57

PDB code: 1BUN Chain idenitifiers: B Start position query: 391 Start position PDB code: 7 End position query: 441 End position PDB code: 57

PDB code: 1UUB Chain idenitifiers: A Start position query: 391 Start position PDB code: 3 End position query: 443 End position PDB code: 53

PDB code: 1FAK Chain idenitifiers: I Start position query: 248 Start position PDB code: 3 End position query: 300 End position PDB code: 55

PDB code: 1DTX Chain idenitifiers: Start position query: 391 Start position PDB code: 7 End position query: 443 End position PDB code: 59

PDB code: 1BRB Chain idenitifiers: I Start position query: 395 Start position PDB code: 9 End position query: 443 End position PDB code: 57

PDB code: 1DEM 1DEN Chain idenitifiers: Start position query: 391 Start position PDB code: 7 End position query: 441 End position PDB code: 57

PDB code: 7PTI Chain idenitifiers: Start position query: 391 Start position PDB code: 5 End position query: 443 End position PDB code: 57

PDB code: 1AAL Chain idenitifiers: A/B Start position query: 391 Start position PDB code: 5 End position query: 443 End position PDB code: 57

PDB code: 1N7D Chain idenitifiers: A Start position query: 334 Start position PDB code: 214 End position query: 438 End position PDB code: 318

PDB code: 1DTK Chain idenitifiers: Start position query: 398 Start position PDB code: 12 End position query: 443 End position PDB code: 57

PDB code: 1F87 Chain idenitifiers: A Start position query: 334 Start position PDB code: 2 End position query: 369 End position PDB code: 37

PDB code: 1D27 Chain idenitifiers: A Start position query: 334 Start position PDB code: 3 End position query: 369 End position PDB code: 38

18.) Name: SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1 [Homo sapiens] Assession: NP_003020 Origin: 1 mnklsggggr rtrveggqlg geewtrhgsf vnkptrgwlh pndkvmgpgv sylvrymgcv 61 evlqsmrald fntrtqvtre aislvceavp gakgatrrrk pcsrplssil grsnlkfagm 121 pitltvstss lnlmaadckq iianhhmqsi sfasggdpdt aeyvayvakd pvnqrachil 181 ecpeglaqdv istigqafel rfkqylrnpp klvtphdrma gfdgsawdee eeeppdhqyy 241 ndfpgkeppl ggvvdmrlre gaapgaarpt apnaqtpshl gatlpvgqpv ggdpevrkqm 301 pppppcpagr elfddpsyvn vqnldkarqa vggagppnpa ingsaprdlf dmkpfedalr 361 vppppqsvsm aeqlrgepwf hgklsrreae allqlngdfl vrestttpgq yvltglqsgq 421 pkhlllvdpe gvvrtkdhrf esvshlisyh mdnhlpiisa gselclqqpv erkl

Variants A95V caused by epigenetic modifications of an alternative promoter M300V caused by epigenetic modifications of an alternative promoter S367L caused by epigenetic modifications of an alternative promoter

PDB code: 1NH3 1OY2 Chain idenitifiers: A Start position query: 1 Start position PDB code: 1 End position query: 207 End position PDB code: 207

PDB code: 1SHC Chain idenitifiers: A Start position query: 371 Start position PDB code: 1 End position query: 474 End position PDB code: 104

PDB code: 1MIL Chain idenitifiers: Start position query: 373 Start position PDB code: 3 End position query: 474 End position PDB code: 104

PDB code: 1TCE Chain idenitifiers: A Start position query: 371 Start position PDB code: 1 End position query: 474 End position PDB code: 104

PDB code: 1RQQ Chain idenitifiers: C/D Start position query: 370 Start position PDB code: 4 End position query: 462 End position PDB code: 102

PDB code: 1RPY Chain idenitifiers: A/B Start position query: 370 Start position PDB code: 4 End position query: 462 End position PDB code: 102

PDB code: 1KSW Chain idenitifiers: A Start position query: 364 Start position PDB code: 52 End position query: 450 End position PDB code: 149

PDB code: 1FMK 2SRC Chain idenitifiers: Start position query: 364 Start position PDB code: 52 End position query: 450 End position PDB code: 149

PDB code: 2PTK Chain idenitifiers: Start position query: 364 Start position PDB code: 53 End position query: 450 End position PDB code: 150 PDB code: 1JU5 Chain idenitifiers: A Start position query: 379 Start position PDB code: 2 End position query: 455 End position PDB code: 98

PDB code:2SHP Chain idenitifiers: A/B Start position query: 377 Start position PDB code: 110 End position query: 470 End position PDB code: 216

PDB code: 1OPK Chain idenitifiers: A Start position query: 364 Start position PDB code: 92 End position query: 450 End position PDB code: 182

PDB code: 2ABL Chain idenitifiers: Start position query: 3364 Start position PDB code: 57 End position query: 450 End position PDB code: 182

PDB code: 1OPL Chain idenitifiers: A/B Start position query: 364 Start position PDB code: 92 End position query: 450 End position PDB code: 221

PDB code: 1K9A Chain idenitifiers: A/B/C/D/E/F Start position query: 366 Start position PDB code: 69 End position query: 450 End position PDB code: 156

PDB code: 1SHD Chain idenitifiers: A Start position query: 372 Start position PDB code: 2 End position query: 450 End position PDB code: 91

PDB code: 1HCT 1HCS Chain idenitifiers: B Start position query: 372 Start position PDB code: 2 End position query: 450 End position PDB code: 91

PDB code: 1AO7 1AO8 1AO9 1A1B 1A1C 1A1E 1A1A Chain idenitifiers: A/B Start position query: 372 Start position PDB code: 2 End position query: 450 End position PDB code: 91

PDB code: 1BKM 1BKL Chain idenitifiers: Start position query: 377 Start position PDB code: 4 End position query: 450 End position PDB code: 88

PDB code: 1041 1042 1043 1044 1045 1046 1047 1048 1048 104A 104B 104C 104D 104E 104F 104G 104H 104I 104J 104K 104L 104M 104N 104O 104P 104Q 104R Chain idenitifiers: A Start position query: 374 Start position PDB code: 2 End position query: 450 End position PDB code: 89

PDB code: 1AB2 Chain idenitifiers: Start position query: 374 Start position PDB code: 6 End position query: 450 End position PDB code: 86

PDB code: 1ISO Chain idenitifiers: A/B Start position query: 375 Start position PDB code: 1 End position query: 450 End position PDB code: 87

PDB code: 1SHA 1SHB Chain idenitifiers: A Start position query: 375 Start position PDB code: 1 End position query: 450 End position PDB code: 87

PDB code: 1SPR Chain idenitifiers: A/B/C/D Start position query: 375 Start position PDB code: 1 End position query: 450 End position PDB code: 87

PDB code: 1SPS Chain idenitifiers: A/B/C Start position query: 375 Start position PDB code: 1 End position query: 450 End position PDB code: 87

PDB code: 1G83 Chain idenitifiers: A/B Start position query: 364 Start position PDB code: 53 End position query: 452 End position PDB code: 152

PDB code: 1P13 1NZL 1NZV Chain idenitifiers: A/B Start position query: 377 Start position PDB code: 2 End position query: 450 End position PDB code: 86

PDB code: 1KC2 Chain idenitifiers: A Start position query: 377 Start position PDB code: 2 End position query: 450 End position PDB code: 86

PDB code: 1SKL Chain idenitifiers: Start position query: 377 Start position PDB code: 4 End position query: 450 End position PDB code: 88 PDB code: 1FHS Chain idenitifiers: Start position query: 373 Start position PDB code: 3 End position query: 450 End position PDB code: 84

PDB code: 1GRI Chain idenitifiers: A/B Start position query: 373 Start position PDB code: 54 End position query: 450 End position PDB code: 135

PDB code: 1FYR Chain idenitifiers: A/B/C/D Start position query: 373 Start position PDB code: 7 End position query: 450 End position PDB code: 88

PDB code: 1BM2 Chain idenitifiers: A Start position query: 373 Start position PDB code: 8 End position query: 450 End position PDB code: 89

PDB code: 1BMB Chain idenitifiers: A Start position query: 373 Start position PDB code: 9 End position query: 450 End position PDB code: 90

PDB code: 1TZE Chain idenitifiers: E Start position query: 374 Start position PDB code: 1 End position query: 450 End position PDB code: 81

PDB code: 1QCE 1ZFP Chain idenitifiers: E Start position query: 378 Start position PDB code: 4 End position query: 450 End position PDB code: 80

PDB code: 1CJ1 Chain idenitifiers: A/B/C/D/E/F/G/H/I/J/K/L Start position query: 378 Start position PDB code: 3 End position query: 450 End position PDB code: 79

PDB code: 1MW4 Chain idenitifiers: A Start position query: 364 Start position PDB code: 3 End position query: 453 End position PDB code: 103

PDB code: 1F1W 1F2F Chain idenitifiers: A Start position query: 377 Start position PDB code: 3 End position query: 450 End position PDB code: 87

PDB code: 1AOT 1AOU Chain idenitifiers: F Start position query: 374 Start position PDB code: 2 End position query: 452 End position PDB code: 91

PDB code: 1JWO Chain idenitifiers: A Start position query: 378 Start position PDB code: 5 End position query: 413 End position PDB code: 42

PDB code: 1GHU Chain idenitifiers: Start position query: 379 Start position PDB code: 3 End position query: 450 End position PDB code: 78

PDB code: 1JYQ Chain idenitifiers: A/B Start position query: 379 Start position PDB code: 5 End position query: 950 End position PDB code: 80

PDB code: 1JYR 1JYU Chain idenitifiers: A Start position query: 379 Start position PDB code: 5 End position query: 950 End position PDB code: 80

PDB code: 1AYA Chain idenitifiers: A/B Start position query: 379 Start position PDB code: 4 End position query: 454 End position PDB code: 83

PDB code: 1AYB 1AYC Chain idenitifiers: A Start position query: 379 Start position PDB code: 4 End position query: 454 End position PDB code: 83

PDB code: 1AYD Chain idenitifiers: Start position query: 379 Start position PDB code: 4 End position query: 454 End position PDB code: 83

PDB code: 1LCJ Chain idenitifiers: A Start position query: 370 Start position PDB code: 1 End position query: 414 End position PDB code: 49

PDB code: 1LCK Chain idenitifiers: A Start position query: 364 Start position PDB code: 61 End position query: 414 End position PDB code: 115

PDB code: 1CSY 1VS7 Chain idenitifiers: A Start position query: 378 Start position PDB code: 14 End position query: 459 End position PDB code: 103

PDB code: 1A81 Chain idenitifiers: A/C/E/G/I/K Start position query: 378 Start position PDB code: 159 End position query: 459 End position PDB code: 248 PDB code: 1BHF 1BHH Chain idenitifiers: A Start position query: 371 Start position PDB code: 1 End position query: 414 End position PDB code: 48

19.) Name: apolipoprotein C-II precursor [Homo sapiens] Assession: NP_000474 Origin: 1 mgtrllpalf lvllvlgfev qgtqqpqqde mpsptfltqv keslssywes aktaaqnlye 61 ktylpavdek lrdlysksta amstytgift dqvlsvlkge e

Variants K60E caused by Human apolipoprotein C-II (apoC-II) slowly forms amyloid fibers in lipid-free solutions at physiological pH and salt concentrations Q77K caused by Human apolipoprotein C-II (apoC-II) slowly forms amyloid fibers in lipid-free solutions at physiological pH and salt concentrations

PDB code:1I5J Chain idenitifiers: A Start position query: 23 Start position PDB code: 1 End position query: 101 End position PDB code: 79

PDB code: 108T Chain idenitifiers: A Start position query: 24 Start position PDB code: 2 End position query: 101 End position PDB code: 79

PDB code: 1BY6 Chain idenitifiers: A Start position query: 67 Start position PDB code: 2 End position query: 101 End position PDB code: 36

PDB code: 1JU2 Chain idenitifiers: A/B Start position query: 15 Start position PDB code: 426 End position query: 48 End position PDB code: 488

PDB code: 1IRU Chain idenitifiers: E/S Start position query: 11 Start position PDB code: 139 End position query: 62 End position PDB code: 185 PDB code: 1R4O 1R4L Chain idenitifiers: A Start position query: 51 Start position PDB code: 31 End position query: 92 End position PDB code: 57

PDB code: 1EZW Chain idenitifiers: A Start position query: 28 Start position PDB code: 122 End position query: 62 End position PDB code: 156

PDB code: 1ETV Chain idenitifiers: A/B Start position query: 28 Start position PDB code: 19 End position query: 84 End position PDB code: 75

20.) Name: WAP four-disulfide core domain 8 precursor; WAP motif protein 1; chromosome 20 open reading frame 170; protease inhibitor WAP8 [Homo sapiens] Assession: NP_570966 Origin: 1 mwtvrteggh fplhsptfsw rnvaflllls lalewtsaml tkkikhkpgl cpkerltctt 61 elpdscntdf dckeyqkccf facqkkcmdp fqepcmlpvr hgncnheaqr whfdfknyrc 121 tpfkyrgceg nannflseda crtacmlivk dgqcplfpft erkecppsch sdidcpqtdk 181 ccesrcgfvc arawtvkkgf cprkpllctk idkpkclqde ecplvekccs hcglkcmdpr 241 r

Variants T96M Caused by alternatively spliced transcript R100Kcaused by alternatively spliced transcript S137N caused by alternatively spliced transcript

PDB code: 1BIK Chain idenitifiers: Start position query: 81 Start position PDB code: 66 End position query: 145 End position PDB code: 132

PDB code: 1DTK Chain idenitifiers: Start position query: 95 Start position PDB code: 5 End position query: 146 End position PDB code: 56

PDB code: 1BRC Chain idenitifiers: I Start position query: 92 Start position PDB code: 2 End position query: 145 End position PDB code: 55

PDB code: 1AAP Chain idenitifiers: A/B Start position query: 92 Start position PDB code: 2 End position query: 145 End position PDB code: 55

PDB code: 1TAW Chain idenitifiers: B Start position query: 92 Start position PDB code: 2 End position query: 145 End position PDB code: 55

PDB code: 1CAO Chain idenitifiers: D/I Start position query: 93 Start position PDB code: 1 End position query: 145 End position PDB code: 53

PDB code: 1IRH Chain idenitifiers: A Start position query: 95 Start position PDB code: 8 End position query: 145 End position PDB code: 58

PDB code: 1SHP Chain idenitifiers: Start position query: 95 Start position PDB code: 2 End position query: 145 End position PDB code: 53

PDB code: 1BF0 Chain idenitifiers: Start position query: 95 Start position PDB code: 7 End position query: 146 End position PDB code: 58

PDB code: 1KNT 1KUN 2KNT Chain idenitifiers: Start position query: 95 Start position PDB code: 5 End position query: 145 End position PDB code: 55 PDB code: 1KTH Chain idenitifiers: A Start position query: 95 Start position PDB code: 5 End position query: 145 End position PDB code: 55

PDB code: 1JC6 Chain idenitifiers: A Start position query: 95 Start position PDB code: 7 End position query: 145 End position PDB code: 57

PDB code: 1DEM 1DEN 1DTX Chain idenitifiers: Start position query: 90 Start position PDB code: 2 End position query: 146 End position PDB code: 58

PDB code: 1FLE Chain idenitifiers: I Start position query: 195 Start position PDB code: 10 End position query: 240 End position PDB code: 57

PDB code: 2REL Chain idenitifiers: Start position query: 195 Start position PDB code: 10 End position query: 240 End position PDB code: 57

PDB code: 1TFX Chain idenitifiers: C/D Start position query: 95 Start position PDB code: 5 End position query: 145 End position PDB code: 55

PDB code: 1ADZ Chain idenitifiers: Start position query: 95 Start position PDB code: 14 End position query: 145 End position PDB code: 64

PDB code: 1BUN Chain idenitifiers: B Start position query: 104 Start position PDB code: 16 End position query: 146 End position PDB code: 58

PDB code: 1UDK Chain idenitifiers: A Start position query: 150 Start position PDB code: 3 End position query: 189 End position PDB code: 44

PDB code: 1CO7 Chain idenitifiers: I Start position query: 79 Start position PDB code: 25 End position query: 145 End position PDB code: 89

PDB code: 1UUB 1UUA Chain idenitifiers: A Start position query: 95 Start position PDB code: 3 End position query: 145 End position PDB code: 53

PDB code: 3BTH 3BTD 4TPI 3TGI 3TGJ 1FSR 1F7Z 3TGK 1TPA 3BTK 2KAI 2PTC 2TGP 3TGI 1FY8 1BZX 1BTT 3BTQ 3BTW 1FAK 3BTG 3BTE 3BTM 3BTF 1P2K 1P2J Chain idenitifiers: I Start position query: 95 Start position PDB code: 5 End position query: 145 End position PDB code: 55

PDB code: 2TPI Chain idenitifiers: I Start position query: 95 Start position PDB code: 6 End position query: 145 End position PDB code: 56

PDB code: 4PTI 5PTI 6PTI 9PTI 1BPI 1PIT 1BTI 1BPT 1NAG 1FAN 8PTI Chain idenitifiers: Start position query: 95 Start position PDB code: 5 End position query: 145 End position PDB code: 55

PDB code: 1EAW 1P2M 1P20 1P2N 1P2Q Chain idenitifiers: B/D Start position query: 95 Start position PDB code: 5 End position query: 145 End position PDB code: 55

PDB code: 1MTN Chain idenitifiers: D/H Start position query: 95 Start position PDB code: 5 End position query: 145 End position PDB code: 55

PDB code: 1LBW Chain idenitifiers: D/I Start position query: 95 Start position PDB code: 5 End position query: 145 End position PDB code: 55

PDB code: 1BTP Chain idenitifiers: P/Q Start position query: 95 Start position PDB code: 5 End position query: 145 End position PDB code: 55

PDB code: 2HEX 1BOC 1BZ5 Chain idenitifiers: A/B/C/D/E Start position query: 95 Start position PDB code: 5 End position query: 145 End position PDB code: 55

PDB code: 1BHC Chain idenitifiers: A/B/C/D/E/F/G/H/I/J Start position query: 95 Start position PDB code: 5 End position query: 145 End position PDB code: 55 PDB code: 1DOB Chain idenitifiers: B Start position query: 95 Start position PDB code: 5 End position query: 145 End position PDB code: 55

PDB code: 10A5 10A6 Chain idenitifiers: 5 Start position query: 95 Start position PDB code: 5 End position query: 145 End position PDB code: 55

PDB code: 1LD6 1QLQ 1G6X 1K60 1LD5 1JV8 1JV9 Chain idenitifiers: A Start position query: 95 Start position PDB code: 5 End position query: 145 End position PDB code: 55

PDB code: 1P2I Chain idenitifiers: T Start position query: 95 Start position PDB code: 5 End position query: 145 End position PDB code: 55

PDB code: 1EJM Chain idenitifiers: B/D/F Start position query: 95 Start position PDB code: 5 End position query: 145 End position PDB code: 55

PDB code: 1BRB Chain idenitifiers: I Start position query: 98 Start position PDB code: 8 End position query: 144 End position PDB code: 55

PDB code: 7PTI Chain idenitifiers: Start position query: 95 Start position PDB code: 5 End position query: 143 End position PDB code: 54 PDB code: 1AAL Chain idenitifiers: A/B Start position query: 95 Start position PDB code: 5 End position query: 143 End position PDB code: 54

21.) Name: serine protease inhibitor-like, with Kunitz and WAP domains 1 isoform 2; epididymal protease inhibitor; WAP four-disulfide core domain 7 [Homo sapiens] Assession: NP_852479 Origin: 1 mlskahgckt alslgrcpki reecefqerd vctkdrqcqd nkkccvfscg kkcldlkqdv 61 cempketgpc layflhwwyd kkdntcsmfv yggcqgnnnn fqskanclnt cknkrfp

Variants H76R caused by Alternatively spliced transcript K112T caused by Alternatively spliced transcript ~It encodes the shorter isoform (2), also known as eppin-2, which has a distinct N-terminus and lacks a signal peptide, as compared to isoform 1. ~they either have alternate polyA sites or encode distinct isoforms.

PDB code: 1P2J 3BTM 1P2K 3BTF 3BTT 3BTW 3BTQ 3BTH 3BTE 3BTD 4TPI 3TGI 3TGJ 1F5R 1F7Z 3TGK 1TPA 1KAI 2PTC 1FY8 3TAI 3BTK 3BTG 1P2I 1BZX Chain idenitifiers: I Start position query: 57 Start position PDB code:1 End position query:111 End position PDB code: 55

PDB code: 1P2N 1P20 1EAW 1P2M 1P2Q Chain idenitifiers: B/D Start position query: 57 Start position PDB code: 1 End position query: 111 End position PDB code: 55

PDB code: 1KNT 2KNT 1KUN Chain idenitifiers: Start position query: 59 Start position PDB code: 3 End position query: 111 End position PDB code: 55

PDB code: 1KTH Chain idenitifiers: A Start position query: 59 Start position PDB code: 3 End position query: 111 End position PDB code: 55

PDB code: 2TPI Chain idenitifiers: I Start position query: 57 Start position PDB code: 2 End position query: 111 End position PDB code: 56

PDB code: 4PTI 6PTI 9PTI 1BTI 1NAG 1FAN 9PTI 1BPT 8PTI Chain idenitifiers: Start position query: 57 Start position PDB code: 1 End position query: 111 End position PDB code: 55

PDB code: 1MTN Chain idenitifiers: D/H Start position query: 57 Start position PDB code: 1 End position query: 111 End position PDB code: 55

PDB code: 1CBW Chain idenitifiers: D/I Start position query: 57 Start position PDB code: 1 End position query: 111 End position PDB code: 55

PDB code: 1BTH Chain idenitifiers: P/Q Start position query: 57 Start position PDB code: 1 End position query: 111 End position PDB code: 55

PDB code: 2HEX 1BOC 1BZ5 Chain idenitifiers: A/B/C/D/E Start position query: 57 Start position PDB code: 1 End position query: 111 End position PDB code: 55

PDB code: 1BHC Chain idenitifiers: A/B/C/D/E/F/G/H/I/J Start position query: Start position PDB code: End position query: End position PDB code:

PDB code: 1DOB Chain idenitifiers: B Start position query: 57 Start position PDB code: 1 End position query: 111 End position PDB code: 55

PDB code: 1LD5 1JV8 1JV9 1QLQ 1G6X 1K6U 1LD6 Chain idenitifiers: A Start position query: 57 Start position PDB code: 1 End position query: 111 End position PDB code: 55

PDB code: 1EJM Chain idenitifiers: B/D/F Start position query: 57 Start position PDB code: 1 End position query: 111 End position PDB code: 55

PDB code: 1AAL Chain idenitifiers: A/B Start position query: 57 Start position PDB code: 1 End position query: 111 End position PDB code: 55

PDB code: 1DTX Chain idenitifiers: Start position query: 57 Start position PDB code: 3 End position query: 111 End position PDB code: 57

PDB code: 1BUN Chain idenitifiers: B Start position query: 61 Start position PDB code: 7 End position query: 115 End position PDB code: 61

PDB code: 1BRC Chain idenitifiers: I Start position query: 58 Start position PDB code: 2 End position query: 111 End position PDB code: 55

PDB code: 1CO7 Chain idenitifiers: I Start position query: 57 Start position PDB code: 35 End position query: 111 End position PDB code: 89

PDB code: 1AAP Chain idenitifiers: A/B Start position query: 58 Start position PDB code: 2 End position query: 111 End position PDB code: 55

PDB code: 1TAW Chain idenitifiers: B Start position query: 58 Start position PDB code: 2 End position query: 111 End position PDB code: 55

PDB code: 1CAO Chain idenitifiers: D/I Start position query: 59 Start position PDB code: 1 End position query: 111 End position PDB code: 53

PDB code: 1PTI Chain idenitifiers: Start position query: 59 Start position PDB code: 3 End position query: 111 End position PDB code: 55

PDB code: 1OA5 10A6 Chain idenitifiers: 5 Start position query: 59 Start position PDB code: 3 End position query: 111 End position PDB code: 55

PDB code: 1UUB 1UUA Chain idenitifiers: A Start position query: 61 Start position PDB code: 3 End position query: 111 End position PDB code: 53

PDB code: 1BTK Chain idenitifiers: Start position query: 57 Start position PDB code: 22 End position query: 112 End position PDB code: 77

PDB code: 1FAK Chain idenitifiers: I Start position query: 59 Start position PDB code: 3 End position query: 111 End position PDB code: 55

PDB code: 1ADZ Chain idenitifiers: Start position query: 56 Start position PDB code: 9 End position query: 113 End position PDB code: 66

PDB code: 1TFX Chain idenitifiers: C/D Start position query: 57 Start position PDB code: 1 End position query: 113 End position PDB code: 57

PDB code: 1BRB Chain idenitifiers: I Start position query: 71 Start position PDB code: 1 End position query: 110 End position PDB code: 54

PDB code: 1IRH Chain idenitif iers:A Start position query: 61 Start position PDB code: 8 End position query: 112 End position PDB code: 59

PDB code: 1JC6 Chain idenitifiers: A Start position query: 61 Start position PDB code: 7 End position query: 114 End position PDB code: 60

PDB code: 1DTK Chain idenitifiers: Start position query: 61 Start position PDB code: 5 End position query: 111 End position PDB code: 55

PDB code: 1DEM 1DEN Chain idenitifiers: Start position query: 66 Start position PDB code: 6 End position query: 114 End position PDB code: 60

PDB code: 1BF0 Chain idenitifiers: Start position query: 61 Start position PDB code: 7 End position query: 114 End position PDB code: 60

PDB code: 1FLE Chain idenitifiers: I Start position query: 15 Start position PDB code: 14 End position query: 53 End position PDB code: 53

PDB code: 2REL Chain idenitifiers: Start position query: 15 Start position PDB code: 14 End position query: 53 End position PDB code: 53

PDB code: 1KO9 Chain idenitifiers: B Start position query: 77 Start position PDB code: 3 End position query: 94 End position PDB code: 25

22.) Name: CCAAT/enhancer binding protein beta; interleukin 6-dependent DNA-binding protein; nuclear factor of interleukin 6; transcription factor 5; liver-enriched transcriptional activator protein [Homo sapiens] Assession: NP_005185 Origin: 1 mqrlvawdpa clplpppppa fksmevanfy yeadclaaay ggkaapaapp aarpgprppa 61 gelgsigdhe raidfspyle plgapqapap atatdtfeaa ppapapapas sgqhhdflsd 121 lfsddyggkn ckkpaeygyv slgrlgaakg alhpgcfapl hppppppppp aelkaepgfe 181 padckrkeea gapgggagma agfpyalray lgyqavpsgs sgslstssss sppgtpspad 241 akapptacya gaapapsqvk skakktvdkh sdeykirrer nniavrksrd kakmrnletq 301 hkvleltaen erlqkkveql srelstlrnl fkqlpeplla ssghc

Variants S195G caused by Calreticulin interacts with C/EBPalpha and C/EBPbeta mRNAs and represses translation of C/EBP proteins

PDB code: 1HJB Chain idenitifiers: A/B/D/E Start position query: 259 Start position PDB code: 1 End position query: 345 End position PDB code: 87

PDB code: 1IO4 1H88 1H8A 1GU4 1GU5 1GTW Chain idenitifiers: A/B Start position query: 259 Start position PDB code: 1 End position query: 336 End position PDB code: 78

PDB code: 1H89 Chain idenitifiers: A/B Start position query: 273 Start position PDB code: 1 End position query: 336 End position PDB code: 64

PDB code: 1CI6 Chain idenitifiers: B Start position query: 273 Start position PDB code: 334 End position query: 2 End position PDB code: 63

PDB code: 1NWQ Chain idenitifiers: A/C Start position query: 270 Start position PDB code: 3 End position query: 328 End position PDB code: 61

PDB code: 1DGC Chain idenitifiers: A Start position query: 267 Start position PDB code: 2 End position query: 322 End position PDB code: 58

PDB code: 2DGC Chain idenitifiers: A Start position query: 267 Start position PDB code: 3 End position query: 322 End position PDB code: 58

PDB code: 1LD4 Chain idenitifiers: E/F/G/H/I/J/K/L Start position query: 271 Start position PDB code: 1 End position query: 322 End position PDB code: 52

PDB code: 105M Chain idenitifiers: A Start position query: 159 Start position PDB code: 19 End position query: 193 End position PDB code: 50

PDB code: 101R 101S 101T Chain idenitifiers: A Start position query: 159 Start position PDB code: 22 End position query: 193 End position PDB code: 53

PDB code: 1FT1 1FPP 1D8D 1D8E 1JCR 1JCS 1KZO 1KZP Chain idenitifiers: A Start position query: 159 Start position PDB code: 19 End position query: 193 End position PDB code: 50

PDB code: 1N4P 1N4Q 1N4R 1N4S Chain idenitifiers: A/C/E/G/I/K Start position query: 159 Start position PDB code: 19 End position query: 193 End position PDB code: 50

PDB code: 1YSA Chain idenitifiers: D Start position query: 272 Start position PDB code: 3 End position query: 322 End position PDB code: 53

PDB code: 1YSA Chain idenitifiers: C Start position query: 272 Start position PDB code: 2 End position query: 322 End position PDB code: 52 PDB code: 1F0S 1AOS Chain idenitifiers: G Start position query: 275 Start position PDB code: 2 End position query: 327 End position PDB code: 54

PDB code: 1A02 Chain idenitifiers: F Start position query: 275 Start position PDB code: 4 End position query: 327 End position PDB code: 56

PDB code: 1FOS Chain idenitifiers: E Start position query: 275 Start position PDB code: 3 End position query: 327 End position PDB code: 55

PDB code: 1PX2 Chain idenitifiers: A/B Start position query: 163 Start position PDB code: 31 End position query: 203 End position PDB code: 77

PDB code: 1PK8 Chain idenitifiers: A/B/C/D/E/F/G/H Start position query: 163 Start position PDB code: 31 End position query: 203 End position PDB code: 77

PDB code: 1F0S Chain idenitifiers: F Start position query: 277 Start position PDB code: 2 End position query: 328 End position PDB code: 53

PDB code: 1JNM Chain idenitifiers: A/B Start position query: 277 Start position PDB code: 5 End position query: 328 End position PDB code: 56

PDB code: 1J1D 1J1E Chain idenitifiers: B/E Start position query: 249 Start position PDB code: 2 End position query: 329 End position PDB code: 84

PDB code: 1FOS Chain idenitifiers: H Start position query: 277 Start position PDB code: 3 End position query: 328 End position PDB code: 54

PDB code: 1C16 Chain idenitifiers: A Start position query: 277 Start position PDB code: 6 End position query: 334 End position PDB code: 64

PDB code: 1A02 Chain idenitifiers: J Start position query: 277 Start position PDB code: 6 End position query: 327 End position PDB code: 56

PDB code: 1EYS Chain idenitifiers: C Start position query: 196 Start position PDB code: 298 End position query: 260 End position PDB code: 366

PDB code: 1CJF Chain idenitifiers: C/D Start position query: 159 Start position PDB code: 4 End position query: 170 End position PDB code: 15

PDB code: 1JVR Chain idenitifiers: Start position query: 147 Start position PDB code: 96 End position query: 179 End position PDB code: 128

PDB code: 1JW3 Chain idenitifiers: A Start position query: 293 Start position PDB code: 589 End position query: 325 End position PDB code: 622

PDB code: 1M7R Chain idenitifiers: A/B Start position query: 293 Start position PDB code: 589 End position query: 325 End position PDB code: 622

PDB code: 1AWI Chain idenitifiers: P Start position query: 162 Start position PDB code: 2 End position query: 170 End position PDB code: 10

PDB code: 1MV3 Chain idenitifiers: A Start position query: 146 Start position PDB code: 21 End position query: 232 End position PDB code: 111

PDB code: 1NAY Chain idenitifiers: A/B/C Start position query: 219 Start position PDB code: 1 End position query: 258 End position PDB code: 40

PDB code: 1JCQ 1LD7 1LD8 1MZC 1SA4 Chain idenitifiers: A Start position query: 147 Start position PDB code: 10 End position query: 197 End position PDB code: 46

PDB code: 1FLC Chain idenitifiers: B/D/F Start position query: 360 Start position PDB code: 38 End position query: 30 End position PDB code: 102

PDB code: 1NXK Chain idenitifiers: A/B/C/D Start position query: 161 Start position PDB code: 30 End position query: 172 End position PDB code: 41

PDB code: 1CF0 Chain idenitifiers: C Start position query: 161 Start position PDB code: 1 End position query: 169 End position PDB code: 8

PDB code: 1KWP Chain idenitifiers: A/B Start position query: 161 Start position PDB code: 30 End position query: 172 End position PDB code: 41

PDB code: 1NY3 Chain idenitifiers: A Start position query: 161 Start position PDB code: 30 End position query: 172 End position PDB code: 41

PDB code: 1FOK 1NLM Chain idenitifiers: A/B Start position query: 193 Start position PDB code: 110 End position query: 258 End position PDB code: 175

PDB code: 1L9M 1L9N 1NUD 1RLE 1VJJ 1SGX 1NUG Chain idenitifiers: A/B Start position query: 193 Start position PDB code: 63 End position query: 236 End position PDB code: 106

PDB code: 1NUF Chain idenitifiers: A Start position query: 193 Start position PDB code: 63 End position query: 236 End position PDB code: 106

23.) Name: CCAAT/enhancer binding protein alpha [Homo sapiens] Assession: NP_004355 Origin: 1 mesadfyeae prppmsshlq spphapssaa fgfprgagpa qppappaape plggicehet 61 sidisayidp aafndeflad lfqhsrqqek akaavgptgg ggggdfdypg apagpggavm 121 pggahgpppg ygcaaagyld grleplyerv gapalrplvi kqepreedea kqlalaglfp 181 yqppppppps hphphpppah laaphlqfqi ahcgqttmhl qpghptpppt pvpsphpapa 241 lgaaglpgpg salkglgaah pdlrasggsg agkakksvdk nsneyrvrre rnniavrksr 301 dkakqrnvet qqkvleltsd ndrlrkrveq lsreldtlrg ifrqlpessl vkamgnca

Variants A238E caused by the encoded protein can interact with CDK2 and CDK4 A252S caused by the encoded protein can interact with CDK2 and CDK4

PDB code: 1HJB Chain idenitifiers: A/B/C/D/E Start position query: 273 Start position PDB code: 4 End position query: 357 End position PDB code: 87

PDB code: 1I04 1H88 1H8A 1GU4 1GU5 1GTW Chain idenitifiers: A/B Start position query: 273 Start position PDB code: 4 End position query: 347 End position PDB code: 78

PDB code: 1NWQ Chain idenitifiers: A/C Start position query: 281 Start position PDB code: 3 End position query: 340 End position PDB code: 62

PDB code: 1H89 Chain idenitifiers: A/B Start position query: 284 Start position PDB code: 1 End position query: 347 End position PDB code: 64

PDB code: 1CI6 Chain idenitifiers: B Start position query: 284 Start position PDB code: 2 End position query: 345 End position PDB code: 63

PDB code: 1DGC Chain idenitifiers: A Start position query: 278 Start position PDB code: 2 End position query: 333 End position PDB code: 57

PDB code: 2DGC Chain idenitifiers: A Start position query: 278 Start position PDB code: 3 End position query: 333 End position PDB code: 58

PDB code: 1JUO Chain idenitifiers: A/B Start position query: 96 Start position PDB code: 5 End position query: 144 End position PDB code: 50 PDB code: 1FOS Chain idenitifiers: G Start position query: 286 Start position PDB code: 2 End position query: 341 End position PDB code: 58

PDB code: 1FOS Chain idenitifiers: E Start position query: 286 Start position PDB code: 3 End position query: 341 End position PDB code: 58

PDB code: 1CD4 Chain idenitifiers: E/F/G/H/I/J/K/L Start position query: 282 Start position PDB code: 1 End position query: 333 End position PDB code: 52

PDB code: 1A02 Chain idenitifiers: F Start position query: 286 Start position PDB code: 4 End position query: 338 End position PDB code: 56

PDB code: 1YSA Chain idenitifiers: O Start position query: 287 Start position PDB code: 7 End position query: 333 End position PDB code: 53

PDB code: 1YSA Chain idenitifiers: C Start position query: 287 Start position PDB code: 6 End position query: 333 End position PDB code: 52

PDB code: 1NXK Chain idenitifiers: A/B/C/D Start position query: 179 Start position PDB code: 14 End position query: 212 End position PDB code: 47

PDB code: 1NY3 Chain idenitifiers: A Start position query: 179 Start position PDB code: 14 End position query: 212 End position PDB code: 47 PDB code: 1KWP Chain idenitifiers: A/B Start position query: 179 Start position PDB code: 14 End position query: 212 End position PDB code: 47

PDB code: 1PK8 Chain idenitifiers: A/B/C/D/E/F/G/H Start position query: 5 Start position PDB code 25: End position query: 118 End position PDB code: 112

PDB code: 1PX2 Chain idenitifiers: A/B Start position query: 5 Start position PDB code: 25 End position query: 118 End position PDB code: 112

PDB code: 1JVR Chain idenitifiers: Start position query: 180 Start position PDB code: 108 End position query: 201 End position PDB code: 129

PDB code: 1CJF Chain idenitifiers: C/D Start position query: 183 Start position PDB code: 1 End position query: 197 End position PDB code: 15

PDB code: 1FOS Chain idenitifiers: F Start position query: 288 Start position PDB code: 2 End position query: 339 End position PDB code: 53

PDB code: 1JNM Chain idenitifiers: A/B Start position query: 288 Start position PDB code: 5 End position query: 339 End position PDB code: 56

PDB code: 1FOS Chain idenitifiers: H Start position query: 288 Start position PDB code: 3 End position query: 339 End position PDB code: 54 PDB code: 1FLC Chain idenitifiers: B/D/F Start position query: 255 Start position PDB code: 20 End position query: 341 End position PDB code: 102

PDB code: 1A02 Chain idenitifiers: J Start position query: 288 Start position PDB code: 6 End position query: 338 End position PDB code: 56

PDB code: 105M Chain idenitifiers: A Start position query: 180 Start position PDB code: 19 End position query: 203 End position PDB code: 41

PDB code: 1NAY Chain idenitifiers: A/B/C Start position query: 22 Start position PDB code: 2 End position query: 68 End position PDB code: 43

PDB code: 101R 101S 101T Chain idenitifiers: A Start position query: 180 Start position PDB code: 22 End position query: 103 End position PDB code: 44

PDB code: 1FT1 1FPP 1D8D 1D8E 1JCR 1JCS 1KZO 1KZP Chain idenitifiers: A Start position query: 185 Start position PDB code: 19 End position query: 203 End position PDB code: 41

PDB code: 1N4P 1N4R 1N1S 1SAS Chain idenitifiers: A/C/E/G/I/K Start position query: 180 Start position PDB code: 19 End position query: 203 End position PDB code: 41 PDB code: 1IJ5 1IJ6 Chain idenitifiers: A Start position query: 280 Start position PDB code: 65 End position query: 355 End position PDB code: 137

PDB code: 1Q1Q Chain idenitifiers: A Start position query: 159 Start position PDB code: 292 End position query: 240 End position PDB code: 350

PDB code: 1S02 Chain idenitifiers: Start position query: 238 Start position PDB code: 13 End position query: 285 End position PDB code: 64

PDB code: 1NKP Chain idenitifiers: A/D Start position query: 302 Start position PDB code: 49 End position query: 345 End position PDB code: 87

PDB code: 1LW6 Chain idenitifiers: E Start position query: 238 Start position PDB codE: 13 End position query: 285 End position PDB code: 64

PDB code: 1ST1 1ST2 1SUB 1SUD 1SO1 1SBI 1SUC 1SBH 1YJC 1YJB 1YJA Chain idenitifiers: Start position query: 238 Start position PDB code: 13 End position query: 285 End position PDB code: 64

PDB code: 2SIC 1SIB 1SBN 3SIC 5SIV 1SUP 1SUN Chain idenitifiers: E Start position query: 238 Start position PDB code: 13 End position query: 285 End position PDB code: 64

PDB code: 1UBN Chain idenitifiers: A Start position query: 238 Start position PDB code: 13 End position query: 285 End position PDB code: 64

PDB code: 1RHI Chain idenitifiers: A Start position query: 97 Start position PDB code: 9 End position query: 132 End position PDB code: 50

PDB code: 1GNY Chain idenitifiers: A Start position query: 238 Start position PDB code: 13 End position query: 299 End position PDB code: 78

PDB code: 1SUE Chain idenitifiers: Start position query: 238 Start position PDB code: 13 End position query: 299 End position PDB code: 78

PDB code: 1DUI 1SUA Chain idenitifiers: A Start position query: 238 Start position PDB code: 13 End position query: 299 End position PDB code: 78

PDB code: 1SPB Chain idenitifiers: S Start position query: 238 Start position PDB code: 13 End position query: 299 End position PDB code: 78

PDB code: 1MV3 Chain idenitifiers: A Start position query: 151 Start position PDB code: 2 End position query: 273 End position PDB code: 134

Name: G-protein coupled receptor 112 [Homo sapiens] Assession: NP_722576 Origin: 1 mddnsrywma fsyitnnall gredidlgla gdhqqlilyr lgktfsirhh lasfqwhtic 61 liwdgvkgkl elflnkeril evtdqphnlt phgtlflghf lknessevks mmrsfpgsly 121 yfqlwdhile neefmkcldg nivsweedvw lvnkiiptvd rtlrcvpenm tiqeksttvs 181 qqidmttpsq itgvkpqnta hsstllsqsi pifatdytti sysnttsppl etmtaqkilk 241 tlvdetatfa vdvlstssai slptqsisid nttnsmkktk spssestktt kmveamatei 301 fqpptpsnfl stsrftknsv vsttsaiksq savtkttslf stiestsmst tpclkqkstn 361 tgalpistag qefiestaag tvpwftvekt spasthvgta ssfppepvli staapvdsvf 421 prnqtafpla ttdmkiaftv hsltlptrli ettpaprtae teltstnfqd vslprvedam 481 stsmsketss ktfsfltsfs ftgtesvqtv idaeatrtal tpeitlastv aetmlsstit 541 grvytqntpt adghlltlms trsastskap esgptsttde aahlfssnet iwtsrpdqal 601 lasmntttil tfvpnenfts afhenttyte ylsattnitp lkaspegkgt tandattary 661 ttavskltsp wfanfsivsg ttsitnmpef klttlllkti pmstkpanel pltpretvvp 721 svdiistlac iqpnfstees asettqtein gaivfggttt pvpksattqr lnatvtrkea 781 tshylmrkst iaavaevspf stmlevtdes aqrvtasvtv ssfpdiekls tpldnktatt 841 evreswlltk lvkttprssy nemtemfnfn htyvahwtse tsegisagsp tsgsthifge 901 plgasttris etsfsttptd rtatslsdgi lppqptaahs satpvpvthm fslpvngssv 961 vaeetevtms epstlarafs tsvlsdvsnl ssttmttalv ppldqtastt ivivpthgdl 1021 irttseatvi svrktsmavp sltetpfhsl rlstpvtaka ettlfstsvd tvtpsthtlv 1081 cskpppdnip passthvist tstpeatqpi sqveetstya lsfpytfsgg gvvaslatgt 1141 tetsvvdett pshisanklt tsvnshisss atyrvhtpvs iqlvtstsvl ssdkdqmtis 1201 lgktprtmev temspsknsf isysrgtpsl emtdtgfpet tkisshqths pseiplgtps 1261 dgnlasspts gstqitptlt ssntvgvhip emstslgkta lpsqaltitt flcpekests 1321 alpaytprtv emivnstyvt hsvsygqdts fvdtttssst risnpmdint tfshlhslrt 1381 qpevtsvasf isestqtfpe slslstagly ndgftvlsdr ittafsvpnv ptmlpressm 1441 atstpiyqms slpvnvtaft skkvsdtppi vitkssktmh pgclkspcta tsgpmsemss 1501 ipvnnsaftp atvssdtstr vglfstllss vtprttmtmq tstldvtpvi yagatsknkm 1561 vssafttemi eapsritptt flspteptlp fvktvpttim agivtpfvgt tafsplssks 1621 tgaissipkt tfspflsatq qssqadeatt lgilsgitnr slstvnsgtg valtdtysri 1681 tvpenmlspt hadslhtsfn iqvspsltsf ksasgptknv ktttncfssn trkmtsllek 1741 tsltnyatsl ntpvsyppwt pssatlpslt sfvysphste aeistpktsp pptsqmvefp 1801 vlgtrmtssn tqpllmtswn iptaegsqfp isttinvpts nemetetlhl vpgplstfta 1861 sqtglvskdv mamssipmsg ilpnhglsen pslstslrai tstladvkht fekmttsvtp 1921 gttlpsilsg atsgsvisks piltwllssl psgsppatvs naphvmtsst vevskstflt 1981 sdmisahpft nlttlpsatm stiltrtipt ptlggittgf ptslpmsinv tddivyisth 2041 peassrttit anprtvshps sfsrktmsps ttdhtlsvga mplpsstits swnriptass 2101 pstliipkpt ldsllnimtt tstvpgasfp listgvtypf tatvsspiss ffettwldst 2161 psflsteast sptatkstep gnckadetas kykgtykwll tnptetaqtr ciknedgnat 2221 rfsisintgk sqwekpkfkq ckllqelpdk ivdlanitis denaedvaeh ilnlinespa 2281 lgkeetkiiv skisdisqcd eismnlthvm lqiinvvlek qnnsasdlhe isneilriie 2341 rtghkmefsg qianltvagl alavlrgdht fdgmafsihs yeegtdpetk nvtkalttyv 2401 vsasisddmf iqnladpvvi tlqhiggnqn ygqvhcafwd fennglggwn ssgckvketn 2461 vnyticqcdh lthfgvlmdl srstvdsvne qilalitytg cgissiflgv avvtyiafkl 2521 rkdypakili nlctallmln lvflinswls sfqkvgvcit aavalhyfll vsftwmglea 2581 vhmylalvkv fniyipnyil kfclvgwgip aimvaitvsv kkdlygtlsp ttpcwikdds 2641 ifyisvvayf cliflmnlsm fctvlvqlns vksqiqktrr kmilhdlkgt msltfllglt 2701 wgfaffawgp mrnfflylfa ifntlqdgss rcqikvgykq eglkkifehk lltpslksta 2761 tsstfkslgs aqgtpseisf pnapelsalh vvasepttg

Variants(these mutations I could not find the mechanism) I212M P304H N1149T P1476S F1727L P2041H

PDB code: 1LK3 Chain idenitifiers: H/I Start position query: 631 Start position PDB code: 50 End position query: 781 End position PDB code: 193

PDB code: 1I3Q 1T50 1I6H 1K93 1N1K 1NT9 1PQV 1R50 1SFO Chain idenitifiers: A Start position query: 2011 Start position PDB code: 1530 End position query: 2195 End position PDB code: 1706

PDB code: 1A6D 1A6E Chain idenitifiers: B Start position query: 2243 Start position PDB code: 273 End position query: 2300 End position PDB code: 341

PDB code: 1EOR Chain idenitifiers: B Start position query: 2243 Start position PDB code: 60 End position query: 2300 End position PDB code: 128

PDB code: 1F90 1F8T Chain idenitifiers: H Start position query: 1727 Start position PDB code: 60 End position query: 1857 End position PDB code: 209

PDB code: 1S51 Chain idenitifiers: H Start position query: 1727 Start position PDB code: 60 End position query: 1857 End position PDB code: 209

PDB code: 1I9R Chain idenitifiers: H/K/X Start position query: 1194 Start position PDB code: 65 End position query: 1313 End position PDB code: 201

PDB code: 1CWV Chain idenitifiers: A Start position query: 406 Start position PDB code: 6 End position query: 700 End position PDB code: 324

PDB code: 1PKQ Chain idenitifiers: B/G Start position query: 1194 Start position PDB code: 88 End position query: 1313 End position PDB code: 222

PDB code: 1J3J 1J3K Chain idenitifiers: A/B Start position query: 2223 Start position PDB code: 60 End position query: 276 End position PDB code: 149

Name: amyloid beta A4 precursor protein-binding, family B, member 2; Fe65-like [Homo sapiens] Assession: NP_775098 Origin: 1 maeedlapgk ssvavnncir qlsyckndir dtvgiwgegk dmylilendm lslvdpmdrs 61 vlhsqpivsi rvwgvgrdng rdfayvardk dtrilkchvf rcdtpakaia tslheicski 121 maerknakal acsslqeran vnldvplqvd fptpktelvq kfhvqylgml pvdkpvgmdi 181 lnsaienlmt ssnkedwlsv nmnvadatvt visekneeev lvecrvrfls fmgvgkdvht 241 fafimdtgnq rfechvfwce pnagnvseav qaacmlryqk clvarppsqk vrpppppads 301 vtrrvttnvk rgvlslidtl kqkrpvtemp

Variants Q165R caused by protein contains two phosphotyrosine binding (PTB) domains

PDB code: 2NMB Chain idenitifiers: A Start position query: 44 Start position PDB code: 70 End position query: 134 End position PDB code: 160

PDB code: 1DDM Chain idenitifiers: A Start position query: 44 Start position PDB code: 55 End position query: 100 End position PDB code: 111

PDB code: 1KV3 Chain idenitifiers: A/B/C/D/E/F Start position query: 217 Start position PDB code: 468 End position query: 293 End position PDB code: 543

PDB code: 1GQQ 1GQY Chain idenitifiers: A/B Start position query: 39 Start position PDB code: 159 End position query: 70 End position PDB code: 190

PDB code: 1CXL 1E0S 1E07 1OT2 1PEZ 1PJP 101T Chain idenitifiers: A Start position query: 101 Start position PDB code: 375 End position query: 145 End position PDB code: 418

PDB code: 1MZG Chain idenitifiers: A/B Start position query: 38 Start position PDB code: 21 End position query: 96 End position PDB code: 79

Name: calpastatin isoform d; calpain inhibitor; sperm BS-17 component; heart-type calpastatin [Homo sapiens] Assession: NP_775085 Origin: 1 misaggesva gitaisgkpg dkkkekkslt pavpveskpd kpsgksgmda alddlidtlg 61 gpeeteeent tytgpevsdp msstyieelg krevtippky rellakpigp ddaidalssd 121 ftcgsptaag kktekeeste vlkaqsagtv rsaappqekk rkvekdtmsd qalealsasl 181 gtrqaepeld lrsikevdea kakeeklekc geddetipse yrlkpatdkd gkpllpepee 241 kpkprsesel idelsedfdr seckekpskp tekteeskaa apapvseavc rtsmcsiqsa 301 ppepatlkgt vpddaveala dslgkkeadp edgkpvmdkv kekakeedre klgekeetip 361 pdyrleevkd kdgkpllpke skeqlppmse dflldalsed fsgpqnassl kfedaklaaa 421 isevvsqtpa sttqagappr dtsqsdkdld daldklsdsl gqrqpdpden kpmedkvkek 481 akaehrdklg erddtippey rhllddngqd kpvkpptkks edskkpaddq dpidalsgdl 541 dscpsttets qntakdkckk aassskapkn ggkakdsakt teetskpkdd

Variation K262E caused by 5' UTR and lacks an exon S290C caused by 5' UTR and lacks an exon A419V caused by 5' UTR and lacks an exon

PDB code: 1MV3 Chain idenitifiers: A Start position query: 225 Start position PDB code: 32 End position query: 311 End position PDB code: 126

PDB code: 1IO2 Chain idenitifiers: A Start position query: 356 Start position PDB code: 27 End position query: 516 End position PDB code: 192

PDB code: 1B6A 1BN5 1BOA Chain idenitifiers: Start position query: 7 Start position PDB code 24: End position query: 169 End position PDB code: 18/5

PDB code: 1QZY 1KQ0 1K09 Chain idenitifiers: A Start position query: 7 Start position PDB code 24: End position query: 169 End position PDB code: 185

PDB code: 1016 Chain idenitifiers: D/E/F Start position query: 506 Start position PDB code: 12 End position query: 588 End position PDB code: 115

PDB code: 1Q60 Chain idenitifiers: A Start position query: 129 Start position PDB code: 14 End position query: 267 End position PDB code: 164

PDB code: 1MHS Chain idenitifiers: A/B Start position query: 3 Start position PDB code 5: End position query: 77 End position PDB code: 74

PDB code: 1L8W Chain idenitifiers: A/B/C/D Start position query:3939 Start position PDB code: 117 End position query: 588 End position PDB code: 396 PDB code: 1JJ2 1KQS 1QVF 1QVG 1S72 Chain idenitifiers: G Start position query: 230 Start position PDB code: 19 End position query: 372 End position PDB code: 334

PDB code: 1K8A 1K9M 1KD1 1M1K 1M90 1K73 1KC8 1N8R 1Q7Y 1Q82 1Q86 Chain idenitifiers: I Start position query: 230 Start position PDB code: 199 End position query: 372 End position PDB code: 334

PDB code: 1YRG Chain idenitifiers: A/B Start position query: 181 Start position PDB code: 311 End position query: 256 End position PDB code: 382

PDB code: 1K5D 1K5G Chain idenitifiers: C/F/I/L Start position query: 181 Start position PDB code: 312 End position query: 250 End position PDB code: 393

PDB code: 1C1G Chain idenitifiers: A/B/C/D Start position query: 162 Start position PDB code: 12 End position query: 456 End position PDB code: 260

PDB code: 1Q6H 1Q6I Chain idenitifiers: A/B Start position query: 129 Start position PDB code: 14 End position query: 267 End position PDB code: 165

PDB code: 1DLY Chain idenitifiers: A Start position query: 27 Start position PDB code: 8 End position query: 85 End position PDB code: 75

PDB code: 1FEU Chain idenitifiers: A/B Start position query: 297 Start position PDB code: 161 End position query: 350 End position PDB code: 206

PDB code: 2TMA Chain idenitifiers: A/B Start position query: 162 Start position PDB code: 12 End position query: 456 End position PDB code: 260

PDB code: 1HL6 Chain idenitifiers: A/C Start position query: 321 Start position PDB code: 8 End position query: 378 End position PDB code: 64

PDB code: 1RK8 Chain idenitifiers: A Start position query: 321 Start position PDB code: 8 End position query: 378 End position PDB code: 64

PDB code: 10Z9 Chain idenitifiers: A Start position query: 159 Start position PDB code: 16 End position query: 206 End position PDB code: 65

PDB code: 1P4X Chain idenitifiers: A Start position query: 346 Start position PDB code: 98 End position query: 385 End position PDB code: 137

PDB code: 1JK0 Chain idenitifiers: A Start position query: 508 Start position PDB code: 18 End position query: 567 End position PDB code: 77

Name: calpastatin isoform c; calpain inhibitor; sperm BS-17 component; heart-type calpastatin [Homo sapiens] Assession: NP_775084 Origin: 1 mgqflsstfl egspatvwhd klcdgerrga reavrifqdq akakeeklek cgeddetips 61 eyrlkpatdk dgkpllpepe ekpkprsese lidelsedfd rseckekpsk ptekteeska 121 aapapvseav crtsmcsiqs appepatlkg tvpddaveal adslgkkead pedgkpvmdk 181 vkekakeedr eklgekeeti ppdyrleevk dkdgkpllpk eskeqlppms edflldalse 241 dfsgpqnass lkfedaklaa aisevvsqtp asttqagapp rdtssdkdld daldklsdsl 301 gqrqpdpden kpmedkvkek akaehrdklg erddtippey rhllddngqd kpvkpptkks 361 edskkpaddq dpidalsgdl dscpsttets qntakdkckk aassskapkn ggkakdsakt 421 teetskpkdd

Vairants K103E differs in the 5' UTR S131C differs in the 5' UTR A260V differs in the 5' UTR

PDB code: 1MV3 Chain idenitifiers: A Start position query: 66 Start position PDB code: 32 End position query: 152 End position PDB code: 126

PDB code: 1B6A 1BN5 1BOA Chain idenitifiers: Start position query: 87 Start position PDB code: 10 End position query: 231 End position PDB code: 142

PDB code: 1QZU 1KQ0 1K09 Chain idenitifiers: A Start position query: 87 Start position PDB code: 10 End position query: 231 End position PDB code: 142

PDB code: 1060 Chain idenitifiers: D/E/F Start position query: 346 Start position PDB code: 12 End position query: 428 End position PDB code: 115

PDB code: 1I02 Chain idenitifiers: A Start position query: 199 Start position PDB code: 27 End position query: 265 End position PDB code: 95

PDB code: 1JJS 1KQS 1QVG 1QVF 1S72 Chain idenitifiers: G Start position query: 71 Start position PDB code: 199 End position query: 213 End position PDB code: 334

PDB code: 1K8A 1K9M 1K01 1M1K 1M90 1K73 1KC8 1N8R 1NJI 1Q7Y 1Q82 1Q86 Chain idenitifiers: I Start position query: 71 Start position PDB code: 199 End position query: 213 End position PDB code: 334

PDB code: 1IJ5 1IJ6 Chain idenitifiers: A Start position query: 41 Start position PDB code: 47 End position query: 160 End position PDB code: 163

PDB code: 1L8W Chain idenitifiers: A/B/C/D Start position query: 361 Start position PDB code: 236 End position query: 428 End position PDB code: 296

PDB code: 1SST Chain idenitifiers: A/B/C Start position query: 220 Start position PDB code: 183 End position query: 294 End position PDB code: 251

PDB code: 1E10 1E1T 1E22 1E24 Chain idenitifiers: A Start position query: 26 Start position PDB code: 4 End position query: 70 End position PDB code: 47

PDB code: 1LYL Chain idenitifiers: A/B/C Start position query: 26 Start position PDB code: 4 End position query: 70 End position PDB code: 47

PDB code: 1SSQ Chain idenitifiers: A/D Start position query: 220 Start position PDB code: 183 End position query: 294 End position PDB code: 251

PDB code: 1S1I Chain idenitifiers: K Start position query:217 Start position PDB code: 16 End position query: 289 End position PDB code: 86

PDB code: 1FEU Chain idenitifiers: A/D Start position query: 138 Start position PDB code: 161 End position query: 191 End position PDB code: 206

PDB code: 1HL6 Chain idenitifiers: A/D Start position query: 162 Start position PDB code: 8 End position query: 219 End position PDB code: 64

PDB code: 1RK8 Chain idenitifiers: A Start position query: 162 Start position PDB code: 8 End position query: 219 End position PDB code: 64

PDB code: 1RIX Chain idenitifiers: A/B Start position query: 244 Start position PDB code: 465 End position query: 298 End position PDB code: 519

PDB code: 1P4X Chain idenitifiers: A Start position query: 187 Start position PDB code: 98 End position query: 226 End position PDB code: 137

PDB code: 1JK0 Chain idenitifiers: A Start position query: 348 Start position PDB code: 118 End position query: 407 End position PDB code: 77

PDB code: 1C1G Chain idenitifiers: A/B/C/D Start position query: 288 Start position PDB code: 14 End position query: 409 End position PDB code: 128

PDB code: 1N54 1N52 Chain idenitifiers: A Start position query: 287 Start position PDB code: 638 End position query: 343 End position PDB code: 709

PDB code: 1H2V Chain idenitifiers: C Start position query: 287 Start position PDB code: 638 End position query: 343 End position PDB code: 690

Name: calpastatin isoform a; calpain inhibitor; sperm BS-17 component; heart-type calpastatin [Homo sapiens] Assession: NP_001741 Origin: 1 mnptetkaip vsqqmegphl pnkkkhkkqa vktepekksq stklsvvhek ksqegkpkeh 61 tepkslpkqa sdtgsndahn kkavsrsaeq qpsekstepk tkpqdmisag gesvagitai 121 sgkpgdkkke kksltpavpv eskpdkpsgk sgmdaalddl idtlggpeet eeenttytgp 181 evsdpmssty ieelgkrevt ippkyrella kkegitgppa dsskpigpdd aidalssdft 241 cgsptaagkk tekeestevl kaqsagtvrs aappqekkrk vekdtmsdqa lealsaslgt 301 rqaepeldlr sikevdeaka keeklekcge ddetipseyr lkpatdkdgk pllpepeekp 361 kprseselid elsedfdrse ckekpskpte kteeskaaap apvseavcrt smcsiqsapp 421 epatlkgtvp ddavealads lgkkeadped gkpvmdkvke kakeedrekl gekeetippd 481 yrleevkdkd gkpllpkesk eqlppmsedf lldalsedfs gpqnasslkf edaklaaais 541 evvsqtpast tqagapprdt sqsdkdldda ldklsdslgq rqpdpdenkp medkvkekak 601 aehrdklger ddtippeyrh llddngqdkp vkpptkksed skkpaddqdp idalsgdlds 661 cpsttetsqn takdkckkaa ssskapkngg kakdsaktte etskpkdd

Variants K380E caused by alternatively splicedtranscript S408C caused byalternatively splicedtranscript A537V caused byalternatively splicedtranscript

PDB code: 1MV3 Chain idenitifiers: A Start position query: 343 Start position PDB code: 32 End position query: 429 End position PDB code: 126 PDB code: 1IO2 Chain idenitifiers: A Start position query: 474 Start position PDB code: 27 End position query: 634 End position PDB code: 192

PDB code: 1B2A 1BN5 1BOA Chain idenitifiers: Start position query: 364 Start position PDB code: 10 End position query: 508 End position PDB code: 142

PDB code: 1QZY 1KQO 1KQ9 Chain idenitifiers: A Start position query: 364 Start position PDB code: 1 End position query: 508 End position PDB code: 142

PDB code: 1060 Chain idenitifiers: D/E/F Start position query: 624 Start position PDB code: 12 End position query: 706 End position PDB code: 115

PDB code: 1Q60 Chain idenitifiers: A Start position query: 217 Start position PDB code: 14 End position query: 385 End position PDB code: 165

PDB code: 1MHS Chain idenitifiers: A/B Start position query: 105 Start position PDB code: 5 End position query: 182 End position PDB code: 74

PDB code: 1IJ5 1IJ6 Chain idenitifiers: A Start position query: 314 Start position PDB code: 43 End position query: 437 End position PDB code: 163

PDB code: 1L8W Chain idenitifiers: A/B/C/D Start position query: 511 Start position PDB code: 117 End position query: 706 End position PDB code: 296

PDB code: 1JJ2 1KQS 1QVF 1QVG 1S72 Chain idenitifiers: G Start position query: 348 Start position PDB code: 199 End position query: 490 End position PDB code: 334

PDB code: 1K84 1K9M 1KD1 1M1K 1M90 1K73 1KL8 1N8R 1NJI 1QZY 1Q81 1Q82 1Q86 Chain idenitifiers: I Start position query: 348 Start position PDB code: 199 End position query: 490 End position PDB code: 334

PDB code: 1YRG Chain idenitifiers: A/B Start position query: 299 Start position PDB code: 311 End position query: 374 End position PDB code: 382

PDB code: 1K50 1K5G Chain idenitifiers: C/F/I/L Start position query: 299 Start position PDB code: 312 End position query: 374 End position PDB code: 383

PDB code: 1C1G Chain idenitifiers: A/B/C/D Start position query: 280 Start position PDB code: 12 End position query: 574 End position PDB code: 260

PDB code: 2FIT 1FIT 5FIT Chain idenitifiers: Start position query: 29 Start position PDB code: 63 End position query: 98 End position PDB code: 132

PDB code: 3FIT Chain idenitifiers: A Start position query: 29 Start position PDB code: 63 End position query: 98 End position PDB code: 132

PDB code: 1Q6H 1Q6T Chain idenitifiers: A/B Start position query: 247 Start position PDB code: 14 End position query: 285 End position PDB code: 165

PDB code: 1EMS Chain idenitifiers: A/B Start position query: 36 Start position PDB code: 366 End position query: 95 End position PDB code: 422

PDB code: 1DLY Chain idenitifiers: A Start position query: 132 Start position PDB code: 8 End position query: 190 End position PDB code: 75

PDB code: 1AKH Chain idenitifiers: A Start position query: 179 Start position PDB code: 8 End position query: 216 End position PDB code: 45

PDB code: 1FEU Chain idenitifiers: A/D Start position query: 415 Start position PDB code: 161 End position query: 468 End position PDB code: 206

PDB code: 2TMA Chain idenitifiers: A/B Start position query: 280 Start position PDB code: 12 End position query: 574 End position PDB code: 260 PDB code: 1HL6 Chain idenitifiers: A/C Start position query: 439 Start position PDB code: 8 End position query: 496 End position PDB code: 64

PDB code: 1RK8 Chain idenitifiers: A Start position query: 439 Start position PDB code: 8 End position query: 496 End position PDB code: 64

PDB code: 1OZ9 Chain idenitifiers: A Start position query: 277 Start position PDB code: 16 End position query: 324 End position PDB code: 65

Name: advanced glycosylation end product-specific receptor isoform 2 precursor [Homo sapiens] Assession: NP_751947 Origin: 1 maagtavgaw vlvlslwgav vgaqnitari geplvlkckg apkkppqrle wklgggpwds 61 varvlpngsl flpavgiqde gifrcqamnr ngketksnyr vrvyqipgkp eivdsaselt 121 agvpnkvgtc vsegsypagt lswhldgkpl vpnekgvsvk eqtrrhpetg lftlqselmv 181 tparggdprp tfscsfspgl prhralrtap iqprvwepvp leevqlvvep eggavapggt 241 vtltcevpaq pspqihwmkd vsdlergagr trrggancrl cgriragnss pgpgdpgrpg 301 dsrpahwghl vakaatprrg eegprkpggr ggacrtesvg gt

Variants S68G caused by multiple differences in the coding region resulting in a frameshift

PDB code: 1C56 Chain idenitifiers: A Start position query: 28 Start position PDB code: 219 End position query: 155 End position PDB code: 340

PDB code: 1QZ1 Chain idenitifiers: A Start position query: 31 Start position PDB code: 115 End position query: 155 End position PDB code: 142

PDB code: 1DGI Chain idenitifiers: R Start position query: 65 Start position PDB code: 76 End position query: 146 End position PDB code: 155 PDB code: 1NN8 Chain idenitifiers: R/S/T Start position query: 65 Start position PDB code: 76 End position query: 146 End position PDB code: 155

PDB code: 1QGC Chain idenitifiers: 4 Start position query: 42 Start position PDB code: 44 End position query: 262 End position PDB code: 270

PDB code: 1RY7 Chain idenitifiers: B Start position query: 102 Start position PDB code: 3 End position query: 279 End position PDB code: 176

PDB code: 1F45 1F42 Chain idenitifiers: Start position query: 215 Start position PDB code: 1 End position query: 271 End position PDB code: 52

PDB code: 1FGV 2FGW Chain idenitifiers: H Start position query: 223 Start position PDB code: 1 End position query: 275 End position PDB code: 56

PDB code: 1IAI Chain idenitifiers: M Start position query: 223 Start position PDB code: 1 End position query: 263 End position PDB code: 42

PDB code: 1AIP Chain idenitifiers: L/A Start position query: 223 Start position PDB code: 1 End position query: 263 End position PDB code: 42

PDB code: 1KOA Chain idenitifiers: Start position query: 225 Start position PDB code: 378 End position query: 277 End position PDB code: 430

PDB code: 1BIH Chain idenitifiers: A/B Start position query: 31 Start position PDB code: 115 End position query: 275 End position PDB code: 361

PDB code: 1CVS 1FQ9 Chain idenitifiers: C/D Start position query: 31 Start position PDB code: 115 End position query: 275 End position PDB code: 361

PDB code: 1H3P Chain idenitifiers: H Start position query: 223 Start position PDB code: 1 End position query: 262 End position PDB code: 52

PDB code: 1MLB Chain idenitifiers: A Start position query: 223 Start position PDB code: 1 End position query: 262 End position PDB code: 40

PDB code: 1MLC Chain idenitifiers: A/C Start position query: 223 Start position PDB code: 1 End position query: 262 End position PDB code: 40

PDB code: 1P2C Chain idenitifiers: A/D Start position query: 223 Start position PDB code: 1 End position query: 262 End position PDB code: 40

PDB code: 1FVC 1FVD 1FVE Chain idenitifiers: B/D Start position query: 223 Start position PDB code: 1 End position query: 259 End position PDB code: 28

PDB code: 1N8Z Chain idenitifiers: B Start position query: 223 Start position PDB code: 1 End position query: 259 End position PDB code: 38

PDB code: 1L7I Chain idenitifiers: H Start position query: 223 Start position PDB code: 1 End position query: 268 End position PDB code: 58

PDB code: 1S78 Chain idenitifiers: D/F Start position query: 223 Start position PDB code: 1 End position query: 268 End position PDB code: 58

PDB code: 1Q1J Chain idenitifiers: H/I Start position query: 223 Start position PDB code: 1 End position query: 245 End position PDB code: 22

PDB code: 1CT8 Chain idenitifiers: A/C Start position query: 223 Start position PDB code: 1 End position query: 262 End position PDB code: 40

PDB code: 1DJS Chain idenitifiers: A Start position query: 90 Start position PDB code: 47 End position query: 146 End position PDB code: 101

PDB code: 1NUN Chain idenitifiers: B Start position query: 90 Start position PDB code: 54 End position query: 146 End position PDB code: 108

PDB code: 1EV2 1I1L Chain idenitifiers: E/F/G/H Start position query: 90 Start position PDB code: 47 End position query: 146 End position PDB code: 101 PDB code: 1L6Z Chain idenitifiers: A Start position query: 64 Start position PDB code: 67 End position query: 110 End position PDB code: 113

PDB code: 1DQJ 1NOM 1DQM 1NBY 1NBZ 1NDG Chain idenitifiers: A Start position query: 223 Start position PDB code: 1 End position query: 262 End position PDB code: 40

PDB code: 1DQM Chain identitifers: L Start position query: 223 Start position PDB code: 1 End position query: 262 End position PDB code: 40

PDB code: 1DQQ Chain identitifers: A/C Start position query: 223 Start position PDB code: 1 End position query: 262 End position PDB code: 40

PDB code: 1GOX Chain identitifers: A Start position query: 31 Start position PDB code: 18 End position query: 85 End position PDB code: 74

PDB code: 1P7Q Chain identitifers: D Start position query: 31 Start position PDB code: 18 End position query: 85 End position PDB code: 74

PDB code: 1PG7 Chain identitifers: H/I Start position query: 223 Start position PDB code: 1 End position query: 259 End position PDB code: 38

PDB code: 1JPS 1JPT Chain identitifers: H Start position query: 223 Start position PDB code: 1 End position query: 259 End position PDB code: 38

PDB code: 1F4W 1F4X 1F4Y Chain identitifers: H Start position query: 223 Start position PDB code: 1 End position query: 271 End position PDB code: 58

PDB code: 1EOO Chain identitifers: B/D Start position query: 90 Start position PDB code: 46 End position query: 146 End position PDB code: 100

PDB code: 1II4 Chain identitifers: E/F/G/H Start position query: 216 Start position PDB code: 106 End position query: 261 End position PDB code: 148

PDB code: 1BLN Chain identitifers: B/D Start position query: 226 Start position PDB code: 3 End position query: 271 End position PDB code: 58

PDB code: 1FHS Chain identitifers: L Start position query: 223 Start position PDB code: 1 End position query: 262 End position PDB code: 40

PDB code: 8FAB Chain identitifers: A/C Start position query: 227 Start position PDB code: 4 End position query: 257 End position PDB code: 34

PBD code: 1VHP Chain identifiers: Start position query: 223 Start psotion PBD code: 1 End position query: 266 End position PBD code: 45 PBD code:1LO4 Chain identifiers: H Start position query 227: Start psotion PBD code: 4 End position query: 262 End position PBD code: 52

PBD code: 1HOD Chain identifiers: B Start position query: 226 Start psotion PBD code: 3 End position query: 271 End position PBD code: 58

PBD code: 1NFD Chain identifiers: E/G Start position query: 226 Start psotion PBD code: 3 End position query: 263 End position PBD code: 39

PBD code: 1BJ1 Chain identifiers: H/K Start position query: 223 Start psotion PBD code: 1 End position query: 245 End position PBD code: 22

PBD code: 1MHP Chain identifiers: H/X Start position query: 223 Start psotion PBD code: 1 End position query: 245 End position PBD code: 22

PBD code: 1RHF Chain identifiers: A/B Start position query: 224 Start psotion PBD code: 3 End position query: 260 End position PBD code: 39

PBD code: 1CZ8 Chain identifiers: H/Y Start position query: 223 Start psotion PBD code: 1 End position query: 245 End position PBD code: 22

PBD code: 1JHL Chain identifiers: L Start position query 223: Start psotion PBD code: 1 End position query: 282 End position PBD code: 64 PBD code: 3HFM Chain identifiers: L Start position query: 223 Start psotion PBD code: 1 End position query: 262 End position PBD code: 40

PBD code: 1C12 Chain identifiers: A Start position query: 223 Start psotion PBD code: 1 End position query: 259 End position PBD code: 37

Name: tumor necrosis factor receptor superfamily, member 6 isoform 7 precursor; apoptosis antigen 1; Fas antigen; APO-1 cell surface antigen [Homo sapiens] Assession: NP_690616 Origin: 1 mlgiwtllpl vltsvarlss ksvnaqvtdi nskglelrkt vttvetqnle glhhdgqfch 61 kpcppdvnme ssrnahspat psakrkdpdl twggfvfffc qfh

Variants A16T caused by autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis

PBD code: 1FRB Chain identifiers: Start position query: 30 Start psotion PBD code: 170 End position query: 90 End position PBD code: 227

PBD code: 1V54 1V55 10CC 20CC 10C0 10CRZ 10CZ Chain identifiers: O/B Start position query: 4 Start psotion PBD code: 64 End position query: 38 End position PBD code: 98

PBD code: 1JE6 Chain identifiers: A Start position query: 18 Start psotion PBD code: 55 End position query: 53 End position PBD code: 89

PBD code: 1JOM 1JON Chain identifiers: A Start position query: 32 Start psotion PBD code: 533 End position query: 82 End position PBD code: 592

Name: angiotensin I converting enzyme isoform 3 precursor; dipeptidyl carboxypeptidase 1; peptidyl- dipeptidase A; kininase II; CD143 antigen; angiotensin converting enzyme, somatic isoform; peptidase P; carboxycathepsin [Homo sapiens] Assession: NP_690044 Origin: 1 mgqgwatagl psllflllcy ghpllvpsqe asqqvtvthg tssqattssq ttthqatahq 61 tsaqspnlvt deaeaskfve eydrtsqvvw neyaeanwny ntnittetsk illqknmqia 121 nhtlkygtqa rkfdvnqlqn ttikriikkv qdleraalpa qeleeynkil ldmettysva 181 tvchpngscl qlepdltnvm atsrkyedll wawegwrdka grailqfypk yvelinqaar 241 lngyvdagds wrsmyetpsl eqdlerlfqe lqplylnlha yvrralhrhy gaqhinlegp 301 ipahllgnmw aqtwsniydl vvpfpsapsm dtteamlkqg wtprrmfkea ddfftslgll 361 pvppefwnks mlekptdgre vvchasawdf yngkdfrikq cttvnledlv vahhemghiq 421 yfmqykdlpv alreganpgf heaigdvlal svstpkhlhs lnllsseggs dehdinflmk 481 maldkiafip fsylvdqwrw rvfdgsitke nynqewwslr lkyqglcppv prtqgdfdpg 541 akfhipssvp yiryfvsfii qfqfhealcq aaghtgplhk cdiyqskeag qrlatamklg 601 fsrpwpeamq litgqpnmsa samlsyfkpl ldwlrtenel hgeklgwpqy nwtpnsddfy 661 netetkiflq fydqtgiwdh gaphllppsq argtreapvy mskraassgp pgspklppaa 721 qghgevpvhd llwhpgppv

Variants P32S caused by associated the presence or absence of a 287 bp Alu repeat element in this gene S49G caused by associated the presence or absence of a 287 bp Alu repeat element in this gene I444T caused by associated the presence or absence of a 287 bp Alu repeat element in this gene K715N caused byassociated the presence or absence of a 287 bp Alu repeat element in this gene

PBD code: 1086 108A Chain identifiers: A Start position query: 68 Start psotion PBD code: 1 End position query: 656 End position PBD code: 589

PBD code: 1J36 1J37 1J38 Chain identifiers: A/B Start position query: 68 Start psotion PBD code: 5 End position query: 647 End position PBD code: 593

PBD code: 1R43 1R4L Chain identifiers: A Start position query: 61 Start psotion PBD code: 15 End position query: 657 End position PBD code: 615

PBD code: 1IQR 1IQU Chain identifiers: A Start position query: 682 Start psotion PBD code: 121 End position query: 739 End position PBD code: 174

Name: nuclear receptor co-repressor 1; thyroid hormone- and retinoic acid receptor-associated corepressor 1 [Homo sapiens] Assession: NP_006302 Origin: 1 msssgyppnq gafsteqsry pphsvqytfp ntrhqqefav pdyrsshlev sqasqllqqq 61 qqqqlrrrps llsefhpgsd rpqerrtsye pfhpgpspvd hdsleskrpr leqvsdshfq 121 rvsaavlplv hplpeglras adakkdpafg gkheapsspi sgqpcgddqn aspsklskee 181 liqsmdrvdr eiakveqqil klkkkqqqle eeaakppepe kpvspppveq khrsivqiiy 241 denrkkaeea hkifeglgpk velplynqps dtkvyhenik tnqvmrkkli lffkrrnhar 301 kqreqkicqr ydqlmeawek kvdriennpr rkakesktre yyekqfpeir kqreqqerfq 361 rvgqrgagls atiarsehei seiidglseq ennekqmrql svippmmfda eqrrvkfinm 421 nglmedpmkv ykdrqfmnvw tdhekeifkd kfiqhpknfg liasylerks vpdcvlyyyl 481 tkknenykal vrrnygkrrg rnqqiarpsq eekveekeed kaektekkee ekkdeeekde 541 kedskentke kdkidgtaee teereqatpr grktansqgr rkgritrsmt neaaaasaaa 601 aaateepppp lppppepist epvetsrwte eemevakkgl vehgrnwaai akmvgtksea 661 qcknfyfnyk rrhnldnllq qhkqktsrkp reerdvsqce svastvsaqe dedieasnee 721 enpedsevea vkpsedspen atsrgntepa veleptteta pstspslavp stkpaedesv 781 etqvndsisa etaeqmdvdq qehsaeegsv cdpppatkad svdvevrvpe nhaskvegdn 841 tkerdldras ekveprdedl vvaqqinaqr pepqsdndss atcsadedvd geperqrmfp 901 mdskpsllnp tgsilvsspl kpnpldlpql qhraavippm vsctpcnipi gtpvsgyaly 961 qrhikamhes alleeqrqrq eqidlecrss tspcgtsksp nrewevlqpa phqvitnlpe 1021 gvrlpttrpt rpppplipss kttvasekps fimggsisqg tpgtyltshn qasytqetpk 1081 psvgsislgl prqqesaksa tlpyikqeef sprsqnsqpe gllvraqheg vvrgtagaiq 1141 egsitrgtpt skisvesips lrgsitqgtp alpqtgipte alvkgsisrm piedsspekg 1201 reeaaskghv iyegksghil sydniknare gtrsprtahe islkrsyesv egnikqgmsm 1261 respvsaple glicralprg sphsdlkert vlsgsimqgt prattesfed glkypkqikr 1321 esppirafeg aitkgkpydg ittikemgrs iheiprqdil tqesrktpev vqstrpiieg 1381 sisqgtpikf dnnsgqsaik hnvkslitgp sklsrgmppl eivpenikvv ergkyedvka 1441 getvrsrhts vvssgpsvlr stlheapkaq lspgiyddts arrtpvsyqn tmsrgspmmn 1501 rtsdvtissn kstnherkst ltptqresip akspvpgvdp vvshspfdph hrgstagevy 1561 rshlpthldp ampfhraldp aaaaylfqrq lsptpgypsq yqlyamentr qtilndyits 1621 qqmqvnlrpd varglspreq plglpypatr giidltnmpp tilvphpggt stppmdrity 1681 ipgtqitfpp rpynsasmsp ghpthlaaaa saerererer ekerereria aassdlylrp 1741 gseqpgrpgs hgyvrspsps vrtqetmlqq rpsvfqgtng tsvitpldpt aqlrimplpa 1801 ggpsisqglp asryntaada laalvdaaas apqmdvsktk eskheaarle enlrsrsaav 1861 seqqqleqkt levekrsvqc lytssafpsg kpqphssvvy seagkdkgpp pksryeeelr 1921 trgkttitaa nfidviitrq iasdkdarer gsqssdssss lsshryetps daievispas 1981 spappqeklq tyqpevvkan qaendptrqy egplhhyrpq qespspqqql ppssqaegmg 2041 qvprthrlit ladhicqiit qdfarnqvss qtpqqpptst fqnspsalvs tpvrtktsnr 2101 yspesqaqsv hhqrpgsrvs penlvdksrg srpgkspers hvssepyepi sppqvpvvhe 2161 kqdsllllsq rgaepaeqrn darspgsisy lpsfftklen tspmvkskkq eifrklnssg 2221 ggdsdmaaaq pgteifnlpa vttsgsvssr ghsfadpasn lglediirka lmgsfddkve 2281 dhgvvmsqpm gvvpgtants vvtsgetrre egdpsphsgg vckpklisks nsrkskspip 2341 gqgylgterp ssvssvhseg dyhrqtpgwa wedrpsstgs tqfpynpltm rmlsstpptp 2401 iacapsavnq aaphqqnriw erepapllsa qyetlsdsdd

Variants E2264V caused by This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17

PBD code: 1I84 Chain identifiers: S Start position query: 1187 Start psotion PBD code: 854 End position query: 554 End position PBD code: 1176

PBD code: 1I84 Chain identifiers: X Start position query: 1187 Start psotion PBD code: 854 End position query: 557 End position PBD code: 1176

PBD code: 1YRG Chain identifiers: A/B Start position query: 499 Start psotion PBD code: 331 End position query: 549 End position PBD code: 382

PBD code: 1K50 1K5G Chain identifiers: C/F/I/L Start position query: 499 Start psotion PBD code: 332 End position query: 549 End position PBD code: 383

Name: cathepsin B preproprotein; APP secretase; preprocathepsin B; cathepsin B1; amyloid precursor protein secretase [Homo sapiens] Assession: NP_680093 Origin: 1 mwqlwaslcc llvlanarsr psfhplsdel vnyvnkrntt wqaghnfynv dmsylkrlcg 61 tflggpkppq rvmftedlkl pasfdareqw pqcptikeir dqgscgscwa fgaveaisdr 121 icihtnahvs vevsaedllt ccgsmcgdgc nggypaeawn fwtrkglvsg glyeshvgcr 181 pysippcehh vngsrppctg egdtpkcski cepgysptyk qdkhygynsy svsnsekdim 241 aeiykngpve gafsvysdfl lyksgvyqhv tgemmgghai rilgwgveng tpywlvansw 301 ntdwgdngff kilrgqdhcg iesevvagip rtdqyweki

Variants: At least five transcript variantsencoding the same protein have been found for this gene.

L26V caused by Incomplete proteolytic processing of APP or overexpression of the encoded protein S53G caused by Incomplete proteolytic processing of APP or overexpression of the encoded protein P91L caused by Incomplete proteolytic processing of APP or overexpression of the encoded protein

PBD code: 1PBH 2PBH 3PBH Chain identifiers: Start position query: 18 Start psotion PBD code: 2 End position query: 333 End position PBD code: 317

PBD code: 1MIR Chain identifiers: A/B Start position query: 20 Start psotion PBD code: 3 End position query: 336 End position PBD code: 319

PBD code: 1GMY Chain identifiers: A/B/C Start position query: 79 Start psotion PBD code: 1 End position query: 339 End position PBD code: 261

PBD code: 1ITO Chain identifiers: A Start position query: 80 Start psotion PBD code: 1 End position query: 335 End position PBD code: 256

Name: amyloid beta A4 precursor protein-binding, family B, member 1 isoform delta E9; amyloid beta A4 precursor protein-binding, family B, member 1; stat-like protein; adaptor protein FE65a2 [Homo sapiens] Assession: NP_663722 Origin: 1 msvpsslsqs ainanshggp alslplplha ahnqllnakl qatavgpkdl rsamgegggp 61 epgpanakwl kegqnqlrra atahrdqnrn vtltlaeeas qepemaplgp kglihlysel 121 elsahnaanr glrgpgliis tqeqgpdege ekaageaeee eeddddeeee edlssppglp 181 eplesveapp rpqaltdgpr ehsksasllf gmrnsaasde dsswatlsqg spsygspedt 241 dsfwnpnafe tdsdlpagwm rvqdtsgtyy whiptgttqw eppgraspsq gsspqeesql 301 twtgfahgeg fedgefwkde psdeapmelg lkepeegtlt fpaqslspep lpqeeeklpp 361 rntnpgikcf avrslgwvem teeelapgrs svavnncirq lsyhknnlhd pmsggwgegk 421 dlllqledet lklvepqsqa llhaqpiisi rvwgvgrdsg rdfayvardk ltqmlkchvf 481 rceapaknia tslheicski maerrnarcl vnglsldhsk lvdvpfqvef papknelvqk 541 fqvyylgnvp vakpvgvdvi ngalesvlss ssreqwtpsh vsvapatlti lhqqteavlg 601 ecrvrflsfl avgrdvhtfa fimaagpasf cchmfwcepn aaslseavqa acmlryqkcl 661 darsqastsc lpappaesva rrvgwtvrrg vqslwgslkp krlgahtp

Variants P60H caused by block cell cycle progression by downregulating thymidylate synthase expression. M327V caused by block cell cycle progression by downregulating thymidylate synthase expression. S396N caused by block cell cycle progression by downregulating thymidylate synthase expression.

PBD code:2NMB Chain identifiers: A Start position query: 37 Start psotion PBD code: 32 End position query: 480 End position PBD code: 126

PBD code: 1DDM Chain identifiers: A Start position query: 370 Start psotion PBD code: 17 End position query: 480 End position PBD code: 111

PBD code: 1P2Z Chain identifiers: A Start position query: 143 Start psotion PBD code: 136 End position query: 258 End position PBD code: 232

PBD code: 1QY8 1QYA 1QY5 Chain identifiers: A Start position query: 91 Start psotion PBD code: 179 End position query: 176 End position PBD code: 253

Name: amyloid beta A4 precursor protein-binding, family A, member 2; neuronal munc18-1-interacting protein 2; X11-like protein; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; neuron- specific X11L protein; adapter protein X11beta [Homo sapiens] Assession: NP_005494 Origin: 1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee 61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee 121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq 181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt 241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf 301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp 361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvkrmqka akikkkanse 421 gdaqtltevd lfistqrikv lnadtqetmm dhalrtisyi adignivvlm arrrmprsas 481 qdciettpga qegkkqykmi chvfesedaq liaqsigqaf svayqeflra nginpedlsq 541 keysdiintq emynddlihf snsenckelq lekhkgeilg vvvvesgwgs ilptvilanm 601 mnggpaarsg klsigdqims ingtslvglp latcqgiikg lknqtqvkln ivscppvttv 661 likrpdlkyq lgfsvqngii cslmrggiae rggvrvghri ieingqsvva tahekivqal 721 snsvgeihmk tmpaamfrll tgqetplyi

Variants P311L caused by hXB51 isoforms regulate Abeta generation differently, either enhancing it by modifying the association of X11L with APP or suppressing it in an X11L-independent manner C604G caused by hXB51 isoforms regulate Abeta generation differently, either enhancing it by modifying the association of X11L with APP or suppressing it in an X11L-independent manner C634G caused by hXB51 isoforms regulate Abeta generation differently, either enhancing it by modifying the association of X11L with APP or suppressing it in an X11L-independent manner

PBD code: 1AQC 1X11 Chain identifiers: A/B Start position query: 364 Start psotion PBD code: 2 End position query: 535 End position PBD code: 172

PBD code: 1N99 1QBZ Chain identifiers: A/B Start position query: 605 Start psotion PBD code: 39 End position query: 734 End position PBD code: 105 PBD code: 1NTE 1R6J Chain identifiers: A Start position query: 671 Start psotion PBD code: 18 End position query: 734 End position PBD code: 81

PBD code: 1UEW Chain identifiers: A Start position query: 561 Start psotion PBD code: 6 End position query: 639 End position PBD code: 89

Name: amyloid beta A4 precursor protein-binding, family A, member 1; phosphotyrosine-binding/- interacting domain (PTB)-bearing protein; neuronal munc18-1-interacting protein 1; neuron-specific X11 protein; adaptor protein X11alpha [Homo sapiens] Assession: NP_001154 Origin: 1 mnhlegsaev evtdeaagge vnesveadle hpeveeeqqq ppqqqhyvgr hqrgraledl 61 raqlgqeeee rgeclarsas tesgfhnhtd taegdviaaa rdgydaeraq dpedesayav 121 qyrpeaeeyt eqaeaehaea thrralpnhl hfhsleheea mnaaysgyvy thrlfhrged 181 epysepyady gglqehvyee igdapeldar dglrlyeqer deaaayrqea lgarlhhyde 241 rsdgesdspe keaefapypr mdsyeqeedi dqivaevkqs mssqsldkaa edmpeaeqdl 301 erpptpaggr pdspglqapa gqqravgpag ggeagqrysk ekrdaislai kdikeaieev 361 ktrtirspyt pdepkepiwv mrqdisptrd cddqrpmdgd spspgssspl gaessstslh 421 psdpveastn kesrkslasf ptyvevpgpc dpedlidgii faanylgstq llsdktpskn 481 vrmmqaqeav srikmaqkla ksrkkapege sqpmtevdlf istqrikvln adtqetmmdh 541 plrtisyiad ignivvlmar rrmprsnsqe nveashpsqd gkrqykmich vfesedaqli 601 aqsigqafsv ayqeflrang inpedlsqke ysdllntqdm ynddlihfsk senckdvfie 661 kqkgeilgvv ivesgwgsil ptviianmmh ggpaeksgkl nigdqimsin gtslvglpls 721 tcqsiikglk nqsrvklniv rcppvttvli rrpdlryqlg fsvqngiics lmrggiaerg 781 gvrvghriie ingqsvvatp hekivhilsn avgeihmktm paamyrllta qeqpvyi

Variants H208D caused by Coexpression of X11alpha with amyloid protein precursor retarded its maturation

PBD code: 1AQC 1X11 Chain identifiers: A/B Start position query: 453 Start psotion PBD code: 2 End position query: 623 End position PBD code: 172

PBD code: 1N99 1OBZ Chain identifiers: A/B Start position query: 683 Start psotion PBD code: 29 End position query: 822 End position PBD code: 165 PBD code: 1UEW Chain identifiers: A Start position query: 649 Start psotion PBD code: 6 End position query: 727 End position PBD code: 89

PBD code: 1N7E Chain identifiers: A Start position query: 661 Start psotion PBD code: 12 End position query: 720 End position PBD code: 69

Name: visinin-like 1 [Homo sapiens] Assession: NP_003376 Origin: 1 mgkqnsklap evmedlvkst efnehelkqw ykgflkdcps grlnleefqq lyvkffpygd 61 askfaqhafr tfdkngdgti dfreficals itsrgsfeqk lnwafnmydl dgdgkitrve 121 mleiieaiyk mvgtvimmkm nedgltpeqr vdkifskmdk nkddqitlde fkeaaksdps 181 ivlllqcdiq k

Variants A65G caused by reversibility and stimulus-dependent occurrence of a calcium-myristoyl switch of VILIP-1 in living neurons S95G caused by reversibility and stimulus-dependent occurrence of a calcium-myristoyl switch of VILIP-1 in living neurons R172K caused by reversibility and stimulus-dependent occurrence of a calcium-myristoyl switch of VILIP- 1 in living neurons

PBD code: 1BJF Chain identifiers: A/B Start position query: 1 Start psotion PBD code: 1 End position query: 188 End position PBD code: 186

PBD code: 1G8I Chain identifiers: A/B Start position query: 1 Start psotion PBD code: 1 End position query: 185 End position PBD code: 183

PBD code: 1FPW Chain identifiers: A Start position query: 1 Start psotion PBD code: 1 End position query: 182 End position PBD code: 180

PBD code: 1IKU 1JSA Chain identifiers: Start position query: 5 Start psotion PBD code: 3 End position query: 191 End position PBD code: 192

Name: CD44 antigen (homing function and Indian blood group system); CD44 antigen (homing function) [Homo sapiens] Assession: NP_000601 Origin: 1 mdkfwwhaaw glclvplsla qidlnitcrf agvfhvekng rysisrteaa dlckafnstl 61 ptmaqmekal sigfetcryg fieghvvipr ihpnsicaan ntgvyiltyn tsqydtycfn 121 asappeedct svtdlpnafd gpititivnr dgtryvqkge yrtnpediyp snptdddvss 181 gssserssts ggyifytfst vhpipdedsp witdstdrip attlmstsat atetatkrqe 241 awdwfswlfl psesknhlht ttqmagtssn tisagwepne enederdrhl sfsgsgiddd 301 edfisstist tprafdhtkq nqdwtqwnps hsnpevllqt ttrmtdvdrn gttayegnwn 361 peahpplihh ehheeeetph ststiqatps stteetatqk eqwfgnrwhe gyrqtpreds 421 hsttgtaaas ahtshpmqgr ttpspedssw tdffnpishp mgrghqagrr mdmdsshstt 481 lqptanpntg lvenldrtgp lsmttqqsns qsfstshegl eedkdhptts tltssnrndv 541 tggrrdpnhs egsttllegy tshyphtkes rtfipvtsak tgsfgvtavt vgdsnsnvnr 601 slsgdqdtfh psggshtthg sesdghshgs qegganttsg pirtpqipew liilasllal 661 alilavciav nsrrrcgqkk klvinsgnga vedrkpsgln geasksqemv hlvnkesset 721 pdqfmtadet rnlqnvdmki gv

Variants Y109S caused by teraction of CD44 when cross-linked on rheumatoid synovial cells with hyaluronan fragments present in the surrounding extracellular matrix T393M caused by teraction of CD44 when cross-linked on rheumatoid synovial cells with hyaluronan fragments present in the surrounding extracellular matrix R417K caused by teraction of CD44 when cross-linked on rheumatoid synovial cells with hyaluronan fragments present in the surrounding extracellular matrix I479T caused by teraction of CD44 when cross-linked on rheumatoid synovial cells with hyaluronan fragments present in the surrounding extracellular matrix H494D caused by teraction of CD44 when cross-linked on rheumatoid synovial cells with hyaluronan fragments present in the surrounding extracellular matrix

PBD code: 1UUH Chain identifiers: A/B Start position query: 20 Start psotion PBD code: 1 End position query: 178 End position PBD code: 159

PBD code: 1POZ Chain identifiers: A Start position query: 20 Start psotion PBD code: 1 End position query: 178 End position PBD code: 159

PBD code: 107B 107C Chain identifiers: T Start position query: 33 Start psotion PBD code: 2 End position query: 123 End position PBD code: 97 PBD code: 1J19 Chain identifiers: A Start position query: 371 Start psotion PBD code: 136 End position query: 420 End position PBD code: 187

Name: beta-site APP-cleaving enzyme 1 isoform D preproprotein; beta-site amyloid beta A4 precursor protein-cleaving enzyme; APP beta-secretase; aspartyl protease 2; beta-site amyloid precursor protein cleaving enzyme; memapsin-2; membrane-associated aspartic protease 2; transmembrane aspartic proteinase Asp2; beta-secretase [Homo sapiens] Assession: NP_620429 Origin: 1 maqalpwlll wmgagvlpah gtqhgirlpl rsglggaplg lrlpretdee peepgrrgsf 61 vemvdnlrgk sgqgyyvemt vgsppqtlni lvdtgssnfa vgaaphpflh ryyqrqlsst 121 yrdlrkgvyv pytqgkwege lgtdllcgag fplnqsevla svggsmiigg idhslytgsl 181 wytpirrewy yeviivrvei ngqdlkmdck eynydksivd sgttnlrlpk kvfeaavksi 241 kaasstekfp dgfwlgeqlv cwqagttpwn ifpvislylm gevtnqsfri tilpqqylrp 301 vedvatsqdd cykfaisqss tgtvmgavim egfyvvfdra rkrigfavsa chvhdefrta 361 avegpfvtld medcgynipq tdestlmtia yvmaaicalf mlplclmvcq wrclrclrqq 421 hddfaddisl lk

Variants *383E caused by generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene R412C caused by generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene

PBD code: 1FKN 1M4H Chain identifiers: A/B Start position query: 146 Start psotion PBD code: 160 End position query: 377 End position PBD code: 391

PBD code: 1SGZ Chain identifiers: A/B/C/D Start position query: 146 Start psotion PBD code: 158 End position query: 377 End position PBD code: 389

PBD code: 1AM5 Chain identifiers: Start position query: 63 Start psotion PBD code: 2 End position query: 350 End position PBD code: 324

PBD code: 1HTR Chain identifiers: B Start position query: 75 Start psotion PBD code: 14 End position query: 350 End position PBD code: 329

Name: beta-site APP-cleaving enzyme 1 isoform B preproprotein; beta-site amyloid beta A4 precursor protein-cleaving enzyme; APP beta-secretase; aspartyl protease 2; beta-site amyloid precursor protein cleaving enzyme; memapsin-2; membrane-associated aspartic protease 2; transmembrane aspartic proteinase Asp2; beta-secretase [Homo sapiens] Assession: NP_620428 Origin: 1 maqalpwlll wmgagvlpah gtqhgirlpl rsglggaplg lrlpretdee peepgrrgsf 61 vemvdnlrgk sgqgyyvemt vgsppqtlni lvdtgssnfa vgaaphpflh ryyqrqlsst 121 yrdlrkgvyv pytqgkwege lgtdlvsiph gpnvtvrani aaitesdkff ingsnwegil 181 glayaeiarl cgagfplnqs evlasvggsm iiggidhsly tgslwytpir rewyyeviiv 241 rveingqdlk mdckeynydk sivdsgttnl rlpkkvfeaa vksikaasst ekfpdgfwlg 301 eqlvcwqagt tpwnifpvis lylmgevtnq sfritilpqq ylrpvedvat sqddcykfai 361 sqsstgtvmg avimegfyvv fdrarkrigf avsachvhde frtaavegpf vtldmedcgy 421 nipqtdestl mtiayvmaai calfmlplcl mvcqwrclrc lrqqhddfad disllk

Variants *427E caused by generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene R456C caused by generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene

PBD code: 1FNA 1M4H Chain identifiers: A/B Start position query: 56 Start psotion PBD code: 1 End position query: 421 End position PBD code: 391

PBD code: 1SGZ Chain identifiers: A/B/C/D Start position query: 58 Start psotion PBD code: 1 End position query: 421 End position PBD code: 389

PBD code: 1AM5 Chain identifiers: Start position query: 32 Start psotion PBD code: 2 End position query: 394 End position PBD code: 324

PBD code: 1AVF Chain identifiers: A/J Start position query: 75 Start psotion PBD code: 14 End position query: 391 End position PBD code: 323 Name: beta-site APP-cleaving enzyme 1 isoform C preproprotein; beta-site amyloid beta A4 precursor protein-cleaving enzyme; APP beta-secretase; aspartyl protease 2; beta-site amyloid precursor protein cleaving enzyme; memapsin-2; membrane-associated aspartic protease 2; transmembrane aspartic proteinase Asp2; beta-secretase [Homo sapiens] Assession: NP_620427 Origin: 1 maqalpwlll wmgagvlpah gtqhgirlpl rsglggaplg lrlpretdee peepgrrgsf 61 vemvdnlrgk sgqgyyvemt vgsppqtlni lvdtgssnfa vgaaphpflh ryyqrqlsst 121 yrdlrkgvyv pytqgkwege lgtdlpddsl epffdslvkq thvpnlfslq lcgagfplnq 181 sevlasvggs miiggidhsl ytgslwytpi rrewyyevii vrveingqdl kmdckeynyd 241 ksivdsgttn lrlpkkvfea avksikaass tekfpdgfwl geqlvcwqag ttpwnifpvi 301 slylmgevtn qsfritilpq qylrpvedva tsqddcykfa isqsstgtvm gavimegfyv 361 vfdrarkrig favsachvhd efrtaavegp fvtldmedcg ynipqtdest lmtiayvmaa 421 icalfmlplc lmvcqwrclr clrqqhddfa ddisllk

Variants *408E caused by generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene R437C caused by generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene

PBD code: 1DI9 1KV2 1KV1 1LEZ 1LEW Chain identifiers: A Start position query: 1 Start psotion PBD code: 1 End position query: 254 End position PBD code: 254

PBD code: 1R39 1OUY 1OUK 1M7Q Chain identifiers: A Start position query: 1 Start psotion PBD code: 7 End position query: 254 End position PBD code: 260

PBD code: 10Z1 Chain identifiers: A Start position query: 1 Start psotion PBD code: 13 End position query: 254 End position PBD code: 266

PBD code: 1BL7 1BL6 1BMK Chain identifiers: A Start position query: 1 Start psotion PBD code: 20 End position query: 254 End position PBD code: 273 Name: mitogen-activated protein kinase 14 isoform 4; cytokine suppressive anti-inflammatory drug binding protein; Csaids binding protein; MAP kinase Mxi2; p38 mitogen activated protein kinase; p38 MAP kinase; p38alpha Exip; stress-activated protein kinase 2A; MAX-interacting protein 2 [Homo sapiens] Assession: NP_620583 Origin: 1 msqerptfyr qelnktiwev peryqnlspv gsgaygsvca afdtktglrv avkklsrpfq 61 siihakrtyr elrllkhmkh enviglldvf tparsleefn dvylvthlmg adlnnivkcq 121 kltddhvqfl iyqilrglky ihsadiihrd lkpsnlavne dcelkildfg larhtddemt 181 gyvatrwyra peimlnwmhy nqtvdiwsvg cimaelltgr tlfpgtdhid qlklilrlvg 241 tpgaellkki sseslstcwr rclywtqire lqrpkplhmp tllsttilmm nqwpilmisp 301 lkagtsl

Variants R237S caused by phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase R243G caused by phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase *245E caused by phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase D245E caused by phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase

PBD code: 1BJF Chain identifiers: A/B Start position query: 1 Start psotion PBD code: 1 End position query: 193 End position PBD code: 193

PBD code: 1G8I Chain identifiers: A/B Start position query: 1 Start psotion PBD code: 1 End position query: 183 End position PBD code: 183

PBD code: 1JMR Chain identifiers: A Start position query: 5 Start psotion PBD code: 2 End position query: 192 End position PBD code: 194

PBD code: 1REC Chain identifiers: Start position query: 5 Start psotion PBD code: 2 End position query: 192 End position PBD code: 194

Same previous

Name: mitogen-activated protein kinase 14 isoform 3; cytokine suppressive anti-inflammatory drug binding protein; Csaids binding protein; MAP kinase Mxi2; p38 mitogen activated protein kinase; p38 MAP kinase; p38alpha Exip; stress-activated protein kinase 2A; MAX-interacting protein 2 [Homo sapiens] Assession: NP_620582 Origin: 1 msqerptfyr qelnktiwev peryqnlspv gsgaygsvca afdtktglrv avkklsrpfq 61 siihakrtyr elrllkhmkh enviglldvf tparsleefn dvylvthlmg adlnnivkcq 121 kltddhvqfl iyqilrglky ihsadiihrd lkpsnlavne dcelkildfg larhtddemt 181 gyvatrwyra peimlnwmhy nqtvdiwsvg cimaelltgr tlfpgtdhid qlklilrlvg 241 tpgaellkki ssesarnyiq sltqmpkmnf anvfiganpl gkltiyphlm dielvmi

PBD code: 1BJF Chain identifiers: A/B Start position query: 1 Start psotion PBD code: 1 End position query: 193 End position PBD code: 193

PBD code: 1G8I Chain identifiers: A/B Start position query: 1 Start psotion PBD code: 1 End position query: 183 End position PBD code: 183

PBD code: 1JMR Chain identifiers: A Start position query: 5 Start psotion PBD code: 2 End position query: 192 End position PBD code: 194

PBD code: 1REC Chain identifiers: Start position query: 5 Start psotion PBD code: 2 End position query: 192 End position PBD code: 194

Same previous Name: mitogen-activated protein kinase 14 isoform 2; cytokine suppressive anti-inflammatory drug binding protein; Csaids binding protein; MAP kinase Mxi2; p38 mitogen activated protein kinase; p38 MAP kinase; p38alpha Exip; stress-activated protein kinase 2A; MAX-interacting protein 2 [Homo sapiens] Assession: NP_620581 Origin: 1 msqerptfyr qelnktiwev peryqnlspv gsgaygsvca afdtktglrv avkklsrpfq 61 siihakrtyr elrllkhmkh enviglldvf tparsleefn dvylvthlmg adlnnivkcq 121 kltddhvqfl iyqilrglky ihsadiihrd lkpsnlavne dcelkildfg larhtddemt 181 gyvatrwyra peimlnwmhy nqtvdiwsvg cimaelltgr tlfpgtdhid qlklilrlvg 241 tpgaellkki ssesarnyiq sltqmpkmnf anvfiganpl avdllekmlv ldsdkritaa 301 qalahayfaq yhdpddepva dpydqsfesr dllidewksl tydevisfvp ppldqeemes

PBD code: 1BJF Chain identifiers: A/B Start position query: 1 Start psotion PBD code: 1 End position query: 193 End position PBD code: 193 PBD code: 1G8I Chain identifiers: A/B Start position query: 1 Start psotion PBD code: 1 End position query: 183 End position PBD code: 183

PBD code: 1JMR Chain identifiers: A Start position query: 5 Start psotion PBD code: 2 End position query: 192 End position PBD code: 194

PBD code: 1REC Chain identifiers: Start position query: 5 Start psotion PBD code: 2 End position query: 192 End position PBD code: 194

Name: hippocalcin-like 1; visinin-like protein 3; calcium-binding protein BDR-1 [Homo sapiens] Assession: NP_602293 Origin: 1 mgkqnsklrp evlqdlrent eftdhelqew ykgflkdcpt ghltvdefkk iyanffpygd 61 askfaehvfr tfdtngdgti dfrefiials vtsrgkleqk lkwafsmydl dgngyisrse 121 mleivqaiyk mvssvmkmpe destpekrtd kifrqmdtnn dgklsleefi rgaksdpsiv 181 rllqcdpssa sqf

Variants S41G caused by calcium-dependent regulation of rhodopsin phosphorylation

PBD code:1F8A Chain identifiers: B Start position query: 21 Start psotion PBD code: 1 End position query: 75 End position PBD code: 54

PBD code: 1UH4 1UH3 1UH3 1IZK 1IZJ Chain identifiers: A Start position query: 41 Start psotion PBD code: 45 End position query: 121 End position PBD code: 120

PBD code: 1JI1 Chain identifiers: A/B Start position query: 41 Start psotion PBD code: 45 End position query: 121 End position PBD code: 120 PBD code: 1MNV 1PIN Chain identifiers: A Start position query: 28 Start psotion PBD code: 4 End position query: 75 End position PBD code: 50

Same as Previous Name: hippocalcin-like 1; visinin-like protein 3; calcium-binding protein BDR-1 [Homo sapiens] Assession: NP_002140 Origin: 1 mgkqnsklrp evlqdlrent eftdhelqew ykgflkdcpt ghltvdefkk iyanffpygd 61 askfaehvfr tfdtngdgti dfrefiials vtsrgkleqk lkwafsmydl dgngyisrse 121 mleivqaiyk mvssvmkmpe destpekrtd kifrqmdtnn dgklsleefi rgaksdpsiv 181 rllqcdpssa sqf

PBD code:1F8A Chain identifiers: B Start position query: 21 Start psotion PBD code: 1 End position query: 75 End position PBD code: 54

PBD code: 1UH4 1UH3 1UH3 1IZK 1IZJ Chain identifiers: A Start position query: 41 Start psotion PBD code: 45 End position query: 121 End position PBD code: 120

PBD code: 1JI1 Chain identifiers: A/B Start position query: 41 Start psotion PBD code: 45 End position query: 121 End position PBD code: 120

PBD code: 1MNV 1PIN Chain identifiers: A Start position query: 28 Start psotion PBD code: 4 End position query: 75 End position PBD code: 50

Name: amyloid beta precursor protein-binding, family B, member 3 isoform f; FE65-like protein 2; amyloid precursor interacting protein [Homo sapiens] Assession: NP_573422 Origin: 1 mlgkdymlai ilvncdddlw gdhsleveag lppgwrkihd aagtyywhvp sgstqwqrpt 61 welgdaedpg tgtegiwglr ppkgrsfssl essldrsnsl swyggesyiq smepgakcfa 121 vrslgwvevp eedlapgkss iavnnciqql aqtrsrsqpp dgawgegqnm lmilkkdams 181 lvnpldhsli hcqplvhirv wgvgsskgrs sdvdpgllpl pgpalvgegg pssagtvwge 241 serlg

Variants R165G caused by unknown

PBD code:1F8A Chain identifiers: B Start position query: 21 Start psotion PBD code: 1 End position query: 75 End position PBD code: 54

PBD code: 1UH4 1UH3 1UH3 1IZK 1IZJ Chain identifiers: A Start position query: 41 Start psotion PBD code: 45 End position query: 121 End position PBD code: 120

PBD code: 1JI1 Chain identifiers: A/B Start position query: 41 Start psotion PBD code: 45 End position query: 121 End position PBD code: 120

PBD code: 1MNV 1PIN Chain identifiers: A Start position query: 28 Start psotion PBD code: 4 End position query: 75 End position PBD code: 50

Same as previous Name: amyloid beta precursor protein-binding, family B, member 3 isoform e; FE65-like protein 2; amyloid precursor interacting protein [Homo sapiens] Assession: NP_573421 Origin: 1 mlgkdymlai ilvncdddlw gdhsleveag lppgwrkihd aagtyywhvp sgstqwqrpt 61 welgdaedpg tgtegiwglr ppkgrsfssl essldrsnsl swyggesyiq smepgakcfa 121 vrslgwvevp eedlapgkss iavnnciqql aqtrsrsqpp dgawgegqnm lmilkkdams 181 lvnpldhsli hcqplavipt dadpqylnpw tqil

PBD code:1F8A Chain identifiers: B Start position query: 21 Start psotion PBD code: 1 End position query: 75 End position PBD code: 54

PBD code: 1UH4 1UH3 1UH3 1IZK 1IZJ Chain identifiers: A Start position query: 41 Start psotion PBD code: 45 End position query: 121 End position PBD code: 120

PBD code: 1JI1 Chain identifiers: A/B Start position query: 41 Start psotion PBD code: 45 End position query: 121 End position PBD code: 120

PBD code: 1MNV 1PIN Chain identifiers: A Start position query: 28 Start psotion PBD code: 4 End position query: 75 End position PBD code: 50

Name: amyloid beta precursor protein-binding, family B, member 3 isoform a; FE65-like protein 2; amyloid precursor interacting protein [Homo sapiens] Assession: NP_573420 Origin: 1 mlgkdymlai ilvncdddlw gdhsleveag lppgwrkihd aagtyywhvp sgstqwqrpt 61 welgdaedpg tgtegiwglr ppkgrsfssl essldrsnsl swyggesyiq smepgakcfa 121 vrslgwvevp eedlapgkss iavnnciqql aqtrsrsqpp dgawgegqnm lmilkkdams 181 lvnpldhsli hcqplvhirv wgvgsskgrd fafvasdkds cmlkchvfrc dvpakaiasa 241 lhglcaqils ervevsgdas ccspdpispe dlprqvelld avsqaaqkye alymgtlpvt 301 kamgmdvlne aigtltargd rnawvptmls vsdslmtahp iqaeasteee plwqcpvrlv 361 tfigvgrdph tfgliadlgr qsfqcaafwc qphagglsea vqaacmvqyq kclvasaarg 421 kawgaqarar lrlkrtssmd spggplplpl lkggvggaga tprkrgvfsf ldafrlkpsl 481 lhmp

Variants R165G caused by unknown R229C caused by unknown

PBD code:1F8A Chain identifiers: B Start position query: 21 Start psotion PBD code: 1 End position query: 75 End position PBD code: 54

PBD code: 1UH4 1UH3 1UH3 1IZK 1IZJ Chain identifiers: A Start position query: 41 Start psotion PBD code: 45 End position query: 121 End position PBD code: 120

PBD code: 1JI1 Chain identifiers: A/B Start position query: 41 Start psotion PBD code: 45 End position query: 121 End position PBD code: 120

PBD code: 1MNV 1PIN Chain identifiers: A Start position query: 28 Start psotion PBD code: 4 End position query: 75 End position PBD code: 50

Same as previous Name: amyloid beta precursor protein-binding, family B, member 3 isoform b; FE65-like protein 2; amyloid precursor interacting protein [Homo sapiens] Assession: NP_573419 Origin: 1 mlgkdymlai ilvncdddlw gdhsleveag lppgwrkihd aagtyywhvp sgstqwqrpt 61 welgdaedpg tgtegiwglr ppkgrsfssl essldrsnsl swyggesyiq smepgakcfa 121 vrslgwvevp eedlapgkss iavnnciqql aqtrsrsqpp dgawgegqnm lmilkkdams 181 lvnpldhsli hcqplvhirv wgvgsskgrd rdfafvasdk dscmlkchvf rcdvpakaia 241 salhglcaqi lservevsgd asccspdpis pedlprqvel ldavsqaaqk yealymgtlp 301 vtkamgmdvl neaigtltar gdrnawvptm lsvsdslmta hpiqaeaste eeplwqcpvr 361 lvtfigvgrd phtfgliadl grqsfqcaaf wcqphaggls eavqaacmvq yqkclvasaa 421 rgkawgaqar arlrlkrtss mdspggplpl pllkggvgga gatprkrgvf sfldafrlkp 481 sllhmp

PBD code:1F8A Chain identifiers: B Start position query: 21 Start psotion PBD code: 1 End position query: 75 End position PBD code: 54

PBD code: 1UH4 1UH3 1UH3 1IZK 1IZJ Chain identifiers: A Start position query: 41 Start psotion PBD code: 45 End position query: 121 End position PBD code: 120

PBD code: 1JI1 Chain identifiers: A/B Start position query: 41 Start psotion PBD code: 45 End position query: 121 End position PBD code: 120

PBD code: 1MNV 1PIN Chain identifiers: A Start position query: 28 Start psotion PBD code: 4 End position query: 75 End position PBD code: 50

Same as previous Name: amyloid beta precursor protein-binding, family B, member 3 isoform c; FE65-like protein 2; amyloid precursor interacting protein [Homo sapiens] Assession: NP_573418 Origin: 1 mlgkdymlai ilvncdddlw gdhsleveag lppgwrkihd aagtyywhvp sgstqwqrpt 61 welgdaedpg tgtegiwglr ppkgrsfssl essldrsnsl swyggesyiq smepgakcfa 121 vrslgwvevp eedlapgkss iavnnciqql aqtrsrsqpp dgawgegqnm lmilkkdams 181 lvnpldhsli hcqplvhirv wgvgsskgrp isapardfaf vasdkdscml kchvfrcdvp 241 akaiasalhg lcaqilserv evsgdasccs pdpispedlp rqvelldavs qaaqkyealy 301 mgtlpvtkam gmdvlneaig tltargdrna wvptmlsvsd slmtahpiqa easteeeplw 361 qcpvrlvtfi gvgrdphtfg liadlgrqsf qcaafwcqph agglseavqa acmvqyqkcl 421 vasaargkaw gaqararlrl krtssmdspg gplplpllkg gvggagatpr krgvfsflda 481 frlkpsllhm p

PBD code:1F8A Chain identifiers: B Start position query: 21 Start psotion PBD code: 1 End position query: 75 End position PBD code: 54

PBD code: 1UH4 1UH3 1UH3 1IZK 1IZJ Chain identifiers: A Start position query: 41 Start psotion PBD code: 45 End position query: 121 End position PBD code: 120

PBD code: 1JI1 Chain identifiers: A/B Start position query: 41 Start psotion PBD code: 45 End position query: 121 End position PBD code: 120

PBD code: 1MNV 1PIN Chain identifiers: A Start position query: 28 Start psotion PBD code: 4 End position query: 75 End position PBD code: 50

Same as previous Name: amyloid beta precursor protein-binding, family B, member 3 isoform d; FE65-like protein 2; amyloid precursor interacting protein [Homo sapiens] Assession: NP_006042 Origin: 1 mlgkdymlai ilvncdddlw gdhsleveag lppgwrkihd aagtyywhvp sgstqwqrpt 61 welgdaedpg tgtegiwglr ppkgrsfssl essldrsnsl swyggesyiq smepgakcfa 121 vrslgwvevp eedlapgkss iavnnciqql aqtrsrsqpp dgawgegqnm lmilkkdams 181 lvnpldhsli hcqplvhirv wgvgsskgrd spisapardf afvasdkdsc mlkchvfrcd 241 vpakaiasal hglcaqilse rvevsgdasc cspdpisped lprqvellda vsqaaqkyea 301 lymgtlpvtk amgmdvlnea igtltargdr nawvptmlsv sdslmtahpi qaeasteeep 361 lwqcpvrlvt figvgrdpht fgliadlgrq sfqcaafwcq phagglseav qaacmvqyqk 421 clvasaargk awgaqararl rlkrtssmds pggplplpll kggvggagat prkrgvfsfl 481 dafrlkpsll hmp

PBD code:1F8A Chain identifiers: B Start position query: 21 Start psotion PBD code: 1 End position query: 75 End position PBD code: 54

PBD code: 1UH4 1UH3 1UH3 1IZK 1IZJ Chain identifiers: A Start position query: 41 Start psotion PBD code: 45 End position query: 121 End position PBD code: 120

PBD code: 1JI1 Chain identifiers: A/B Start position query: 41 Start psotion PBD code: 45 End position query: 121 End position PBD code: 120

PBD code: 1MNV 1PIN Chain identifiers: A Start position query: 28 Start psotion PBD code: 4 End position query: 75 End position PBD code: 50

Name: similar to amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein; proline-rich protein 73; Rap1-interacting adaptor molecule [Homo sapiens] Assession: XP_084436 Origin: 1 msqalcqkdk lkgpikgitk psgqmpqaah svsavlekaq thaetwkvkp algnhqepga 61 prprrapssa cpnpsgadme apqdfvpppp avakrppmph phkrheasmf rcrk

Variants W46S caused by unknown

PBD code: 1JLW Chain identifiers: A/B Start position query: 364 Start psotion PBD code: 52 End position query: 511 End position PBD code: 217 PBD code: 4HB1 Chain identifiers: Start position query: 387 Start psotion PBD code: 21 End position query: 465 End position PBD code: 101

PBD code: 1NCN 1I85 Chain identifiers: A/B Start position query: 230 Start psotion PBD code: 4 End position query: 315 End position PBD code: 88

PBD code: 1SJJ Chain identifiers: A/B Start position query: 414 Start psotion PBD code: 347 End position query: 471 End position PBD code: 401

Name: amyloid beta precursor protein-binding protein 2; amyloid beta precursor protein (cytoplasmic tail)- binding protein 2; protein interacting with APP tail 1 [Homo sapiens] Assession: NP_006371 Origin: 1 maavelewip etlyntaisa vvdnyirsrr dirslpeniq fdvyyklyqq grlcqlgsef 61 celevfakvl raldkrhllh hcfqalmdhg vkvasvlays fsrrcsyiae sdaavkekai 121 qvgfvlggfl sdagwysdae kvflsclqlc tlhdemlhwf raveccvrll hvrngnckyh 181 lgeetfklaq tymdklskhg qqankaalyg elcallfaks hydeaykwci eamkeitagl 241 pvkvvvdvlr qaskacvvkr efkkaeqlik havylardhf gskhpkysdt lldygfylln 301 vdnicqsvai yqaaldirqs vfggknihva tahedlayss yvhqyssgkf dnalfhaera 361 igiithilpe dhlllasskr vkalileeia idchnketeq rllqeahdlh lsslqlakka 421 fgefnvqtak hygnlgrlyq smrkfkeaee mhikaiqike qllgqedyev alsvghlasl 481 ynydmnqyen aeklylrsia igkklfgegy sgleydyrgl iklynsigny ekvfeyhnvl 541 snwnrlrdrq ysvtdaledv stspqsteev vqsflisqnv egpsc

Variants L296F caused by unkown R325K caused by unknown S340C caused by unknown P369R caused by unknown K542N caused by unknown

PBD code: 1RMG Chain identifiers: Start position query: 135 Start psotion PBD code: 190 End position query: 202 End position PBD code: 230

PBD code: 1SKZ Chain identifiers: Start position query: 65 Start psotion PBD code: 64 End position query: 90 End position PBD code: 88

PBD code: 1VZ2 Chain identifiers: A Start position query: 40 Start psotion PBD code: 31 End position query: 94 End position PBD code: 82

PBD code: 1VHV Chain identifiers: A/B Start position query: 212 Start psotion PBD code: 10 End position query: 242 End position PBD code: 40

Name: BBP-like protein 2 isoform a [Homo sapiens] Assession: NP_510883 Origin: 1 maggvrplrg lralcrvllf lsqfcilsgg eqsqalaqsi kdpgptrtft vvpraaeste 61 ippyvmkcps nglcsrlpad cidcttnfsc tygkpvtfdc avkpsvtcvd qdfksqknfi 121 inmtcrfcwq lpetdyectn stscmtvscp rqrypanctv rdhvhclgnr tfpkmlycnw 181 tggykwstal alsitlggfg adrfylgqwr eglgklfsfg glgiwtlidv lligvgyvgp 241 adgslyi

Variants R6L caused by unknown L14V caused by unknown

PBD code: 1Q40 Chain identifiers: B/D Start position query: 35 Start psotion PBD code: 141 End position query: 72 End position PBD code: 178

PBD code: 1NLM 1FOK Chain identifiers: A/B Start position query: 15 Start psotion PBD code: 70 End position query: 66 End position PBD code: 121

PBD code: 1EVS Chain identifiers: A Start position query: 20 Start psotion PBD code: 118 End position query: 58 End position PBD code: 157

PBD code: 1VBE 1VBC 1VBB 1VBA 1PVC 1PTV Chain identifiers: 2 Start position query: 6 Start psotion PBD code: 174 End position query: 23 End position PBD code: 188

Name: BBP-like protein 1 isoform a [Homo sapiens] Assession: NP_510882 Origin: 1 mvlggcpvsy lllcgqaall lgnllllhcv srshsqnata epeltsagaa qpegpggaas 61 weygdphspv ilcsylpdef iecedpvdhv gnatasqelg ygclkfggqa ysdvehtsvq 121 chaldgieca sprtflrenk pcikytghyf ittllysffl gcfgvdrfcl ghtgtavgkl 181 ltlgglgiww fvdlillitg glmpsdgsnw ctvy

Variants A54G caused by unknown

PBD code: 1NSA Chain identifiers: Start position query: 23 Start psotion PBD code: 1 End position query: 346 End position PBD code: 355

PBD code: 1KWM Chain identifiers: A/B Start position query: 23 Start psotion PBD code: 7 End position query: 346 End position PBD code: 361

PBD code: 1CPB Chain identifiers: Start position query: 120 Start psotion PBD code: 6 End position query: 346 End position PBD code: 266

PBD code: 1PCA Chain identifiers: Start position query: 77 Start psotion PBD code: 57 End position query: 346 End position PBD code: 266

Same as Previous Name: BBP-like protein 1 isoform b [Homo sapiens] Assession: NP_114146 Origin: 1 mvlggcpvsy lllcgqaall lgnllllhcv srshsqnata epeltsagaa qpegpggaas 61 weygdphspv ilcsylitpf fnisf

PBD code: 1NSA Chain identifiers: Start position query: 23 Start psotion PBD code: 1 End position query: 346 End position PBD code: 355

PBD code: 1KWM Chain identifiers: A/B Start position query: 23 Start psotion PBD code: 7 End position query: 346 End position PBD code: 361

PBD code: 1CPB Chain identifiers: Start position query: 120 Start psotion PBD code: 6 End position query: 346 End position PBD code: 266

PBD code: 1PCA Chain identifiers: Start position query: 77 Start psotion PBD code: 57 End position query: 346 End position PBD code: 266

Name: plasma carboxypeptidase B2 isoform b; carboxypeptidase U; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase B-like protein; thrombin-activable fibrinolysis inhibitor [Homo sapiens] Assession: NP_057497 Origin: 1 mklcslavlv pivlfceqhv fafqsgqvla alprtsrqvq vlqnltttye ivlwqpvtad 61 livkkkqvhf fvnasdvdnv kahlnvsgip csvlladved liqqqisndt vsprasasyy 121 eqyhslneiy swiefiterh pdmltkihig ssfekyplyv lkvsgkeqaa knaiwidcgi 181 harewispaf clwfighnrm wrknrsfyan nhcigtdlnr nfaskhwcee gasssscset 241 ycglypesep evkavasflr rninqikayi smhsysqhiv fpysytrsks kdheelslva 301 seavraieki skntrythgh gsetlylapg ggddwiydlg ikysftsnpp vekllplslk

Variants A169T caused by After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. I310T caused by After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region.

PBD code: 1NGB 1BA1 Chain identifiers: Start position query: 28 Start psotion PBD code: 4 End position query: 389 End position PBD code: 384

PBD code: 1HSC 1NGJ 1NGI 1HPM 1BUP 1NGH 1NGF 1NGD 1NGA 1ATR 1NGG 1NGE 1NGC 1ATS 1BAO Chain identifiers: Start position query: 28 Start psotion PBD code: 4 End position query: 398 End position PBD code: 384

PBD code: 1HX1 Chain identifiers: A Start position query: 28 Start psotion PBD code: 23 End position query: 386 End position PBD code: 400

PBD code: 1KAY 1KAZ Chain identifiers: Start position query: 28 Start psotion PBD code: 4 End position query: 386 End position PBD code: 381

Name: heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); BiP; heat shock 70kD protein 5 (glucose-regulated protein, 78kD); Heat-shock 70kD protein-5 (glucose-regulated protein, 78kD) [Homo sapiens] Assession: NP_005338 Origin: 1 mklslvaaml lllsaaraee edkkedvgtv vgidlgttys cvgvfkngrv eiiandqgnr 61 itpsyvaftp egerligdaa knqltsnpen tvfdakrlig rtwndpsvqq dikflpfkvv 121 ekktkpyiqv digggqtktf apeeisamvl tkmketaeay lgkkvthavv tvpayfndaq 181 rqatkdagti aglnvmriin eptaaaiayg ldkregekni lvfdlgggtf dvslltidng 241 vfevvatngd thlggedfdq rvmehfikly kkktgkdvrk dnravqklrr evekakrals 301 sqhqarieie sfyegedfse tltrakfeel nmdlfrstmk pvqkvledsd lkksdideiv 361 lvggstripk iqqlvkeffn gkepsrginp deavaygaav qagvlsgdqd tgdlvlldvc 421 pltlgietvg gvmtkliprn tvvptkksqi fstasdnqpt vtikvyeger pltkdnhllg 481 tfdltgippa prgvpqievt feidvngilr vtaedkgtgn knkititndq nrltpeeier 541 mvndaekfae edkklkerid trnelesyay slknqigdke klggklssed ketmekavee 601 kiewleshqd adiedfkakk keleeivqpi isklygsagp pptgeedtae kdel

Variants E345V stimulated by HCV replicons

PBD code: 3HSC 1NGJ 1NGI 1HPM 1NGB 1NGH 1NGF 1NGD 1NGA 1ATR 1NGG 1NGE 1NGC 1ATS 1BAO 1BA1 Chain identifiers: Start position query: 28 Start psotion PBD code: 4 End position query: 409 End position PBD code: 384

PBD code: 1BUP Chain identifiers: A Start position query: 28 Start psotion PBD code: 4 End position query: 409 End position PBD code: 384

PBD code: 1HX1 Chain identifiers: A Start position query: 28 Start psotion PBD code: 23 End position query: 406 End position PBD code: 400

PBD code: 1KAY 1KAZ Chain identifiers: Start position query: 28 Start psotion PBD code: 4 End position query: 406 End position PBD code: 381

Name: ADAM 17 precursor (A disintegrin and metalloproteinase domain 17) (TNF-alpha converting enzyme) (TNF-alpha convertase) Assession: Q9Z0F8 Origin: 1 mrrrlliltt lvpfvlaprp peeagsgahp rlekldslls dydilslani qqhsirkrdl 61 qsathletll tfsalkrhfk lyltssterf sqnlrvvvvd gkeeseysvk wqdffsghvv 121 gepdsrvlah igdddvtvri ntdgaeynie plwrfvndtk dkrmlvykse dikdfsrlqs 181 pkvcgylnad seellpkgli drepseefvr rvkrraepnp lkntckllvv adhrfykymg 241 rgeestttny lielidrvdd iyrntswdna gfkgygvqie qirilkspqe vkpgerhfnm 301 aksfpneekd awdvkmlleq fsfdiaeeas kvclahlfty qdfdmgtlgl ayvgsprans 361 hggvcpkayy nptvkkniyl nsgltstkny gktiltkead lvtthelghn fgaehdpdgl 421 aecapnedqg gkyvmypiav sgdhennkmf sncskqsiyk tieskaqecf qersnkvcgn 481 srvdegeecd pgimylnndt ccnsdctlkp gvqcsdrnsp cckncqfeta qkkcqeaina 541 tckgvsyctg nssecpppgd aeddtvcldl gkckagkcip fckreqeles cacvdtdnsc 601 kvccrnlsgp cvpyvdaeqk nlflrkgkpc tvgfcdmngk cekrvqdvie rfwdfidqls 661 intfgkflad nivgsvlvfs lifwipfsil vhcvdkkldk qyeslslfhh sniemlssmd 721 sasvriikpf papqtpgrlq alqpaammpp vsaapkldhq rmdtiqedps tdshvdddgf 781 ekdpfpnsst aaksfedltd hpvtrsekaa sfklqrqsrv dsketec

Variants RR3..4QS caused by inhibition by tissue inhibitors of metalloproteinases (TIMPs) I7F caused by inhibition by tissue inhibitors of metalloproteinases (TIMPs) A28S caused by TNF-alpha converting enzyme (TACE/ADAM17) I149V caused by TNF-alpha converting enzyme (TACE/ADAM17) I594V cuased by TNF-alpha converting enzyme (TACE/ADAM17) GKCEKRVQDVIERFWDF 639..6555CDFFSPYRANVRNEYRT caused by S752P caused by TNF-alpha converting enzyme (TACE/ADAM17) V775A caused by TNF-alpha converting enzyme (TACE/ADAM17)

PBD code: 1BKC Chain identifiers: I Start position query: 219 Start psotion PBD code: 1 End position query: 474 End position PBD code: 256

PBD code: 1BKC Chain identifiers: A Start position query: 219 Start psotion PBD code: 1 End position query: 473 End position PBD code: 2555

PBD code: 1BKE Chain identifiers: E Start position query: 219 Start psotion PBD code: 1 End position query: 474 End position PBD code: 256

PBD code: 1BKC Chain identifiers: I Start position query: 221 Start psotion PBD code: 1 End position query: 474 End position PBD code: 254

Name: Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP) Assession: O55042 Origin: 1 mdvfmkglsk akegvvaaae ktkqgvaeaa gktkegvlyv gsktkegvvh gvttvaektk 61 eqvtnvggav vtgvtavaqk tvegagniaa atgfvkkdqm gkgeegypqe giledmpvdp 121 gseayempse egyqdyepea

Variants K58T caused by mutation in non-Abeta component of Alzheimer's disease amyloid precursor protein (NACP)

PBD code: 1F8G 1L7E 1L7D Chain identifiers: A/B/C/D Start position query: 7 Start psotion PBD code: 195 End position query: 98 End position PBD code: 286

PBD code: 1HZZ 1PTL 1NMS Chain identifiers: A/B Start position query: 7 Start psotion PBD code: 195 End position query: 98 End position PBD code: 286

PBD code: 1L7D Chain identifiers: B Start position query: 7 Start psotion PBD code: 195 End position query: 98 End position PBD code: 286 PBD code: 1PJT Chain identifiers: A/B Start position query: 1 Start psotion PBD code: 411 End position query: 4 End position PBD code: 450

Name: Insulin promoter factor-1 (IPF-1) (Pancreas/duodenum homeobox-1) (PDX-1) (Islet/duodenum homeobox-1) (IDX-1) (Somatostatin transactivating factor-1) (STF-1) (Insulin upstream factor-1) (IUF-1) (Glucose-sensitive factor) (GSF) Assession: P52945 Origin: 1 mngeeqyyaa tqlykdpcaf qrgpapefsa sppaclymgr qpppppphpf pgalgaleqg 61 sppdispyev ppladdpava hlhhhlpaql alphppagpf pegaepgvle epnrvqlpfp 121 wmkstkahaw kgqwaggaya aepeenkrtr taytraqlle lekeflfnky isrprrvela 181 vmlnlterhi kiwfqnrrmk wkkeedkkrg ggtavggggv aepeqdcavt sgeellalpp 241 ppppggavpp aapvaaregr lppglsaspq pssvaprrpq epr

Variants C18R caused by MODY4 A56S caused by MODY4 Q59L caused by MODY4 D76N caused by MODY4 Q116H caused by MODY4 R197H caused by MODY4 GG210..SS conflict P243PP caused byMODY4

PBD code: 9ANT Chain identifiers: A/B Start position query: 145 Start psotion PBD code: 2 End position query: 204 End position PBD code: 61

PBD code: 2HOA 1HOM Chain identifiers: Start position query: 147 Start psotion PBD code: 3 End position query: 208 End position PBD code: 64

PBD code: 1AHD Chain identifiers: P Start position query: 145 Start psotion PBD code: 3 End position query: 208 End position PBD code: 64

PBD code: 1SAN Chain identifiers: 153 Start position query: 3 Start psotion PBD code: 208 End position query: 58 End position PBD code:

Name: C4b-binding protein alpha chain precursor (C4bp) (Proline-rich protein) (PRP) Assession: P04003 Origin: 1 mhppktpsga lhrkrkmaaw pfsrlwkvsd pilfqmtlia allpavlgnc gppptlsfaa 61 pmditltetr fktgttlkyt clpgyvrshs tqtltcnsdg ewvyntfciy krcrhpgelr 121 ngqveiktdl sfgsqiefsc segffligst tsrcevqdrg vgwshplpqc eivkckpppd 181 irngrhsgee nfyaygfsvt yscdprfsll ghasisctve netigvwrps pptcekitcr 241 kpdvshgemv sgfgpiynyk dtivfkcqkg fvlrgssvih cdadskwnps ppacepnsci 301 nlpdiphasw etyprptked vyvvgtvlry rchpgykptt depttvicqk nlrwtpyqgc 361 ealccpepkl nngeitqhrk srpanhcvyf ygdeisfsch etsrfsaicq gdgtwsprtp 421 scgdicnfpp kiahghykqs ssysffkeei iyecdkgyil vgqaklscsy shwsapapqc 481 kalcrkpelv ngrlsvdkdq yvepenvtiq cdsgygvvgp qsitcsgnrt wypevpkcew 541 etpegceqvl tgkrlmqclp npedvkmale vyklsleieq lelqrdsarq stldkel

Variants Q92T caused by C3b/C4b inactivator (C3bINA) Y357H caused by C3b/C4b inactivator (C3bINA) W473L caused by C3b/C4b inactivator (C3bINA)

PBD code: 1NJJ Chain identifiers: A Start position query: 47 Start psotion PBD code: 2 End position query: 294 End position PBD code: 255

PBD code: 1NTL Chain identifiers: A/B Start position query: 49 Start psotion PBD code: 2 End position query: 356 End position PBD code: 311

PBD code: 1RID 1G40 Chain identifiers: A/B Start position query: 65 Start psotion PBD code: 19 End position query: 294 End position PBD code: 242

PBD code: 1G44 Chain identifiers: A/B/C Start position query: 65 Start psotion PBD code: 19 End position query: 294 End position PBD code: 242

Name: C4b-binding protein beta chain precursor Assession: P20851 Origin: 1 mffwcacclm vawrvsasda ehcpelppvd nsifvakeve gqilgtyvci kgyhlvgkkt 61 lfcnaskewd ntttecrlgh cpdpvlvnge fsssgpvnvs dkitfmcndh yilkgsnrsq 121 cledhtwapp fpicksrdcd ppgnpvhgyf egnnftlgst isyycedryy lvgvqeqqcv 181 dgewssalpv ckliqeapkp ecekallafq esknlceame nfmqqlkesg mtmeelkysl 241 elkkaelkak ll

Variants P198S caused by C3b/C4b inactivator (C3bINA)

PBD code: 1RID 1G40 Chain identifiers: A/B Start position query: 47 Start psotion PBD code: 33 End position query: 208 End position PBD code: 198

PBD code: 1G44 Chain identifiers:A/B Start position query: 47 Start psotion PBD code: 33 End position query: 208 End position PBD code: 198

PBD code: 1NTJ Chain identifiers: A Start position query: 11 Start psotion PBD code: 114 End position query: 192 End position PBD code: 320

PBD code: 1ESG Chain identifiers: A Start position query: 81 Start psotion PBD code: 3 End position query: 193 End position PBD code: 120

Name: Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer's disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP- alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99; Beta-amyloid protein 42 (Beta-APP42); Beta- amyloid protein 40 (Beta-APP40); C83; P3(42); P3(40); Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59) (Amyloid intracellular domain 59) (AID(59)); Gamma-CTF(57) (Gamma-secretase C- terminal fragment 57) (Amyloid intracellular domain 57) (AID(57)); Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50) (Amyloid intracellular domain 50) (AID(50)); C31] Assession: P05067 Origin: 1 mlpglallll aawtaralev ptdgnaglla epqiamfcgr lnmhmnvqng kwdsdpsgtk 61 tcidtkegil qycqevypel qitnvveanq pvtiqnwckr grkqckthph fvipyrclvg 121 efvsdallvp dkckflhqer mdvcethlhw htvaketcse kstnlhdygm llpcgidkfr 181 gvefvccpla eesdnvdsad aeeddsdvww ggadtdyadg sedkvvevae eeevaeveee 241 eadddedded gdeveeeaee pyeeatertt siattttttt esveevvrev cseqaetgpc 301 ramisrwyfd vtegkcapff yggcggnrnn fdteeycmav cgsamsqsll kttqeplard 361 pvklpttaas tpdavdkyle tpgdenehah fqkakerlea khrermsqvm reweeaerqa 421 knlpkadkka viqhfqekve sleqeaaner qqlvethmar veamlndrrr lalenyital 481 qavpprprhv fnmlkkyvra eqkdrqhtlk hfehvrmvdp kkaaqirsqv mthlrviyer 541 mnqslsllyn vpavaeeiqd evdellqkeq nysddvlanm iseprisygn dalmpsltet 601 kttvellpvn gefslddlqp whsfgadsvp antenevepv darpaadrgl ttrpgsgltn 661 ikteeisevk mdaefrhdsg yevhhqklvf faedvgsnkg aiiglmvggv viatvivitl 721 vmlkkkqyts ihhgvvevda avtpeerhls kmqqngyenp tykffeqmqn

Variants AR15..16VW caused by AD D647E caused by AD E665D caused by AD KM670..671NL caused by AD A692G caused by AD E693Q caused by CEREBROARTERIAL AMYLOIDOSIS E693G caused by AD E693K caused by CEREBROARTERIAL AMYLOIDOSIS D694N caused by CEREBROARTERIAL AMYLOIDOSIS A713V caused by AD A713T caused by AD T714I caused by AD V715M caused by AD I716V caused by AD V717F caused by AD V717G caused by AD V717I caused by AD V717L caused by AD L723P caused by AD I731N caused by AD

PBD code: 1MWP Chain identifiers: A Start position query: 28 Start psotion PBD code: 1 End position query: 123 End position PBD code: 96

PBD code: 1OWT Chain identifiers: A Start position query: 124 Start psotion PBD code: 1 End position query: 189 End position PBD code: 66

PBD code: 1TAW Chain identifiers: A Start position query: 287 Start psotion PBD code: 1 End position query: 344 End position PBD code: 58

PBD code: 1AAP Chain identifiers: A/B Start position query: 287 Start psotion PBD code: 1 End position query: 344 End position PBD code: 58