Reading: Burns and Leg Ulcer Treatment

Reading: Burns and Leg Ulcer Treatment Vocabulary to accelerate autologous benefit biopsy burns cell processing cell suspension chronic compression bandage cosmetic donor enzyme to harvest harvesting process to heal healing process to incubate laboratory to minimise pigment pigment loss pigmentation plastic reconstructive to reduce reduction to regenerate regulation regulatory to reject rejection scar scar formation skin biopsy skin defect skin graft skin sample to spray spray-on tissue tissue rejection

© Reading: Burns and Leg Ulcer Treatment by Virginia Allum 2017 Page 1 Activity: Complete the text using words from the vocabulary list. Check your answer with the transcript. ReCell Spray-On Skin is a type of ______cell harvesting process. By coating a wound or skin ______with a layer of regenerated skin cells, the healing process is accelerated markedly. Scar formation is ______and tissue rejection is also avoided to a large extent. Pigmentation can also be reintroduced to the skin, for example in cases of ______loss in burns.

These features make the ReCell process of interest in ______, plastic and reconstructive procedures. The ______procedure enables cell processing at the site of treatment without the use of specialised ______staff. The process involves taking a small skin ______of about 2 cm squared. The skin sample is then ______in an enzyme cocktail for about 20 minutes.

Once processed, the cell suspension is available to spray an area up to 80 times the area of the ______biopsy. The wound is then covered with a dressing. The dressing falls off after new ______starts to grow, between five to seven days afterwards.

In 2012, the Australian-based company, Avita Medical, obtained ______clearance for ReCell in Europe, Australia and China. US and Canadian researchers had tested the ______skin on 228 people with chronic leg ulcers.

Leg ulcers typically ______very slowly and affect around 1.5% of the general population and over 3% of people over the age of 70. Management of leg ulcers using ______bandages heals about 70% of ulcers on average, after six months. Skin ______taken from other parts of the body are generally used for large areas which have not ______completely. Skin grafting is expensive and requires long hospital stays.

In contrast, the ulcers of more than 60% of patients ______with ReCell were healed within five weeks. Almost all patients reported an immediate ______in pain within 24 hours of the treatment. Experts also claimed that faster ______could save money despite the cost of the spray.

The National Institute for Health and Care Excellence is currently conducting further research on the use of ReCell to treat ______. Early thinking was that the ReCell system showed promise. However, further research on patient and systems ______was needed, before recommending its routine adoption in the NHS.

© Reading: Burns and Leg Ulcer Treatment by Virginia Allum 2017 Page 2 Transcript: ReCell Spray-On Skin is a type of autologous cell harvesting process. By coating a wound or skin defect with a layer of regenerated skin cells, the healing process is accelerated markedly. Scar formation is minimised and tissue rejection is also avoided to a large extent. Pigmentation can also be reintroduced to the skin, for example in cases of pigment loss in burns. These features make the ReCell process of interest in cosmetic, plastic and reconstructive procedures. The harvesting procedure enables cell processing at the site of treatment without the use of specialised laboratory staff. The process involves taking a small skin biopsy of about 2 cm squared. The skin sample is then incubated in an enzyme cocktail for about 20 minutes. Once processed, the cell suspension is available to spray an area up to 80 times the area of the donor biopsy. The wound is then covered with a dressing. The dressing falls off after new skin starts to grow, between five to seven days afterwards. In 2012, the Australian-based company, Avita Medical, obtained regulatory clearance for ReCell in Europe, Australia and China. US and Canadian researchers had tested the spray-on skin on 228 people with chronic leg ulcers.

Leg ulcers typically heal very slowly and affect around 1.5% of the general population and over 3% of people over the age of 70. Management of leg ulcers using compression bandages heals about 70% of ulcers on average, after six months. Skin grafts taken from other parts of the body are generally used for large areas which have not healed completely. Skin grafting is expensive and requires long hospital stays. In contrast, the ulcers of more than 60% of patients sprayed with ReCell were healed within five weeks. Almost all patients reported an immediate reduction in pain within 24 hours of the treatment. Experts also claimed that faster healing could save money despite the cost of the spray.

The National Institute for Health and Care Excellence is currently conducting further research on the use of ReCell to treat burns. Early thinking was that the ReCell system showed promise. However, further research on patient and systems benefits was needed, before recommending its routine adoption in the NHS.

© Reading: Burns and Leg Ulcer Treatment by Virginia Allum 2017 Page 3 Pictures used in the video: http://i.dailymail.co.uk/i/pix/2012/02/17/article-2102612-11C988D5000005DC-726_634x408.jpg https://staticseekingalpha.a.ssl.fastly.net/uploads/2012/5/8/saupload_surgical-scar_thumb1.jpg http://mrmc.amedd.army.mil/assets/images/articles/DSC_0026m.jpg http://i.dailymail.co.uk/i/pix/2012/02/17/article-2102612-11C988C3000005DC-47_636x387.jpg