Supplementary Table 3. Correlation of PTEN FISH in Triple Negative with Clinico-Pathological

Supplementary Table 3. Correlation of PTEN FISH in Triple Negative with clinico- pathological parameters in Breast Cancer Total PTEN Deleted PTEN Normal / Gain p value N % N % N % Total Number of Cases 140 17 12.1 123 87.9 Age < 50 107 76.4 14 13.1 93 86.9 0.5276 > 50 33 23.6 3 9.1 30 90.9 Tumor size* ≤ 2 cm 22 16.2 3 13.6 19 86.4 0.8617 >2 cm 114 83.8 14 12.3 100 87.7 Lymph Nodes* Negative 53 41.4 9 17.0 44 83.0 0.2012 Positive 75 58.6 7 9.3 68 90.7 Metastasis* M0 108 84.4 12 11.1 96 88.9 0.2966 M1 20 15.6 4 20.0 16 80.0 Tumour Stage* I 10 8.3 1 10.0 9 90.0 0.7512 II 51 42.1 7 13.7 44 86.3 III 40 33.1 4 10.0 36 90.0 IV 20 16.5 4 20.0 16 80.0 Histological Grade * Well differentiated 0 0 0 0 0 0 0.3589 Moderately differentiated 36 25.9 6 16.7 30 83.3 Poorly differentiated 103 74.1 11 10.7 92 89.3 Histology* Infiltrating Ductal Carcinoma 133 98.5 17 12.8 116 87.2 0.4613 Infiltrating Lobular 2 1.5 0 0 2 100.0 Mucinous Ca 0 0 0 0 0 0 LVI* Yes 42 34.1 7 16.7 35 83.3 0.1941 No 81 65.8 7 8.6 74 91.4 ETE* Yes 40 38.1 5 12.5 35 87.5 0.5986 No 65 61.9 6 9.2 59 90.8 Tumor Recurrence* Yes 38 30.7 6 15.8 32 84.2 0.4115 No 86 69.3 9 10.5 77 89.5 Ki-67* Positive 131 93.6 17 13.0 114 87.0 0.1202 Negative 9 6.4 0 0 9 100.0 pAKT (ser-473)* Negative 88 63.8 10 11.4 78 88.6 0.6530 Positive 50 36.2 7 14.0 43 86.0 PTEN IHC* High 19 14.0 0 0 19 100.0 0.0191 Low 117 86.0 17 14.5 100 85.5 Basal-like Breast Cancer Yes 126 90.0 14 11.1 112 88.9 0.2988 No 14 10.0 3 21.4 11 78.6 Survival OS 5 Years 56.6 73.3 0.2838

* Data was not available (NA) for some cases: Tumor size (NA=04), Lymph nodes (NA=12), Metastasis (NA=12), Stage (NA=19), Grade (NA=01) , Histology (NA=05), LVI(NA=17), ETE (NA=35), Recurrence (NA=16) , pAKT(ser- 473) (NA=02) & PTEN IHC (NA=04).