Assistant Professor of Chemistry

Znosko, 1 BRENT M. ZNOSKO Assistant Professor of Chemistry

Department of Chemistry Phone: (314) 977-8567 Saint Louis University Email: [email protected] Saint Louis, MO 63103 Fax: (314) 977-2521

EDUCATION

Ph.D., Chemistry, University of Rochester, NY. June 2004. Dissertation: Thermodynamic and Structural Properties of RNA Oligomers Containing Purine Rich Internal Loops and DNA:RNA Hybrids with C5-Propynyl Substitutions. Advisor: Prof. Douglas Turner.

M.S., Chemistry, University of Rochester, NY. May 2001. Curriculum: Quantum Mechanics, Thermodynamics & Statistical Mechanics, Biophysical Chemistry I & II, Special Topics in RNA. Other courses attended: Computational Chemistry, Preparing for Academic Careers in Engineering and Science.

B.S., Chemistry (magna cum laude) with Honors, Allegheny College, Meadville, PA May 1999. Senior Research: Thermodynamics of single nucleotide bulges in RNA duplexes. Advisor: Prof. Martin Serra.

PUBLICATIONS

Chen, G., Znosko, B. M., Kennedy, S. D., Krugh, T. R., and Turner, D. H. (2005) Solution structure of an RNA internal loop with three consecutive sheared GA pairs. Biochemistry 44, 2845-2856.

Znosko, B. M., Kennedy, S. D., Wille, P. C., Krugh, T. R., and Turner, D. H. (2004) Structural features and thermodynamics of the J4/5 loop from the Candida albicans and Candida dubliniensis group I introns. Biochemistry 43, 15822-15837.

Chen, G., Znosko, B. M., Jiao, X., and Turner, D. H. (2004) Factors affecting thermodynamic stabilities of RNA 3x3 internal loops. Biochemistry 43, 12865-12876.

Znosko, B. M., Barnes T. W., Krugh T. R., and Turner, D. H. (2003) NMR studies of DNA single strands and DNA:RNA hybrids with and without 1-propynylation at C5 of oligopyrimidines. J. Am. Chem. Soc. 125, 6090-6097.

Znosko, B. M., Burkard, M. E., Krugh, T. R., and Turner, D. H. (2002) Molecular recognition in purine-rich internal loops: Thermodynamic, structural, and dynamic consequences of purine for adenine substitutions in 5’(rGGCAAGCCU)2. Biochemistry 41, 14978-14987.

Znosko, B. M., Burkard, M. E., Schroeder, S. J., Krugh, T. R., and Turner, D. H. (2002) Sheared

AantiAanti base pairs in a destabilizing 2x2 internal loop: The NMR structure of 5’(rGGCAAGCCU)2. Biochemistry 41, 14969-14977.

Znosko, B. M., Silvestri, S. B., Volkman, H., Boswell, B., and Serra, M. J. (2002) Thermodynamic Znosko, 2 parameters for an expanded nearest-neighbor model for the formation of RNA duplexes with single nucleotide bulges. Biochemistry 41, 10406-10417.

ABSTRACTS AND PRESENTATIONS (Presenters are underlined and undergraduates are asterisked.)

Wright, D. J.*, Rice, J. L.*, and Znosko, B. M. Thermodynamic parameters of RNA duplexes containing inosine. RNA 2005: Tenth Annual Meeting of the RNA Society (Poster).

Znosko, B. M., Kennedy, S. D., Wille, P. C., Krugh, T. R., and Turner, D. H. Structural features and thermodynamics of the J4/5 loop from the Candida albicans group I intron. RNA 2005: Tenth Annual Meeting of the RNA Society (Poster).

Wright, D. J.*, Rice, J. L.*, and Znosko, B. M. Thermodynamic parameters of RNA duplexes containing inosine. Nucleic Acid Gordon Conference (Poster).

Znosko, B. M., Kennedy, S. D., Wille, P. C., Krugh, T. R., and Turner, D. H. Structural features and thermodynamics of the J4/5 loop from the Candida albicans group I intron. Nucleic Acid Gordon Conference (Poster).

Wright, D. J.*, Rice, J. L.*, and Znosko, B. M. Thermodynamic parameters of RNA duplexes containing inosine. 2005 Undergraduate Research Symposium sponsored by the St. Louis Section of the ACS. Awarded first place in the poster category (Poster).

Znosko, B. M., Kennedy, S. D., Wille, P. C., Krugh, T. R., and Turner, D. H. Structural features and thermodynamics of the J4/5 loop from the Candida albicans intron. Saint Louis University Biology Department 2005 Seminar (Talk).

Chen, G., Znosko, B.M., Kennedy, S.D., Jiao, X., Krugh, T.R., and Turner, D.H. Improved Thermodynamic Model for Predicting RNA 3 X 3 Internal Loops and NMR Structure of an Unusually Stable Loop with Three Consecutive Sheared GA Pairs. 2004 Biological Chemistry Cluster in Department of Chemistry (Poster).

Znosko, B. M., Kennedy, S. D., Wille, P. C., Krugh, T. R., and Turner, D. H. Structural features and thermodynamics of the J4/5 loop from the Candida albicans intron. Sigma Xi Saint Louis University Chapter Fall 2004 Research Symposium (Poster).

Ferrin-O’Connell, I., Bellows, B., Znosko, B. M., Grover, N., and Turner, D. H. Examining the thermodynamic stability and metal binding properties of domain II of the hammerhead ribozyme. 2004 Nucleic Acid Gordon Conference (Poster).

Ferrin-O'Connell, I., Znosko, B. M., Grover, N., and Turner, D. H. Thermodynamics of hammerhead domain II oligonucleotide mimics. 2003 Rochester Research Experience for Undergraduates Poster Session (Poster).

Wille, P., Znosko, B. M., Krugh, T. R., and Turner, D. H. Thermodynamic and structural determination of the Candida albicans 2x2 internal loop. 2003 Rochester Research Experience for Undergraduates Poster Session (Poster). Znosko, 3 Znosko, B. M., Barnes, T. W., Krugh, T. R., and Turner, D. H. NMR studies of DNA single strands and DNA:RNA hybrids with and without 1-propynylation at C5 of oligopyrimidines. Upstate New York Structural Biology Day 2003 (Talk).

Znosko, B. M., Burkard, M. E., Barnes, T. W., Schroeder, S. J., Krugh, T. R., and Turner, D. H. Providing structural insights into the thermodynamics of oligonucleotides: Purine-rich internal loops and propynylated systems. 2002 Rochester Biophysical Seminar (Talk).

Znosko, B. M. Thermodynamic and structural studies of purine rich internal loops. Rochester RNA Structure and Function Cluster Meeting 2002 (Talk).

Serra, M. J., Silvestri, S. B., Volkman, H., Boswell, B., and Znosko B. M. Thermodynamic parameters for RNA bulge formation. 2002 National Meeting of the American Chemical Society (Poster).

Skelly, K., Znosko, B. M., Krugh, T. R. Synthesis and thermodynamics of six-nucleotide RNA hairpin loops. 2001 Rochester Research Experience for Undergraduates Poster Session (Poster).

Znosko, B. M., and Serra, M. J. Thermodynamics of single nucleotide bulges in RNA duplexes. 1999 National Conference of Undergraduate Research (Poster).

HONORS AND AWARDS

• SLU Summer Research Award, 7/05-9/05. • First place awarded to Daniel J. Wright, Jamie L. Rice, and Brent M. Znosko for the poster presentation “Thermodynamic parameters of RNA duplexes containing inosine” at the 2005 Undergraduate Research Symposium sponsored by the St. Louis Section of the ACS, 5/05. • LI-COR Biosciences Genomics Education Matching Fund, 3/05. • SLU Beaumont Faculty Development Fund, 1/05-12/05. • W. D. Walters Teaching Award, 4/04. • Agnes M. and George Messersmith Fellowship (awarded by the Dean to 2 students per year campus-wide), 9/03-7/04. • Oral Cellular and Molecular Biology Training Grant Trainee (declined), 9/03. • Elon Huntington Hooker Graduate Fellowship (awarded by the Dean to 5 students per year campus- wide), 9/02-9/03. • Sherman Clarke Fellowship, 9/99-7/04. • Allegheny Alden Scholar, 9/95-5/98, Distinguished Alden Scholar, 9/98-5/99. • PPG Industries Foundation Community Scholarship, 9/95-5/99. • Allegheny Presidential Merit Scholarship, 9/95-5/99.