Human Physiology in Medicine (MSBS 5081S)

Human Physiology in Medicine (MSBS 5081S) Molecular Basis of Physiology (Rutgers 16:761:580) Spring 2017 (3 credits) Course Syllabus

Course Times: Tuesdays and Thursdays, 10:00 – 11:30 am

Room: V10, RWJMS Research Tower, 675 Hoes Lane, Piscataway, NJ

Course Director: Joseph D. Fondell, Ph.D. Department of Pharmacology Room 500A, RWJMS Tower Bldg. 732-235-3348 [email protected] Office hours: available upon request

Course Lecturers: Drs. Fondell, Runnels, Zhang, Weiss, Pang, Fan, Pintar, Kwan, Breslin, Cai, Jin, Jacinto, Bunting, Soto, Kramer, Sabaawy, Alder, Varia, Zachow.

Course Description: This is a lecture/research paper discussion course covering the molecular basis of human physiological systems and related methodologies used in modern physiological and medical research. Designed to further extend and supplement areas covered in the companion course Physiological Basis of Disease (and courses in the core MBS/MSBS curriculum), this course is subdivided into six parts including: 1) Nerve and Muscle Physiology, 2) Hormones, Signal Transduction, and Regulation of Gene Expression, 3) Sensory Physiology (hearing, taste, vision, smell, pain), 4) Cellular and Physiological Homeostasis, 5) Pathophysiology of Metabolic Diseases, and 6) Animals Models to Study Human Physiology and Disease. A total of 24 lectures will be given by a diverse group of expert scientists and physicians from across the Rutgers, CINJ and RWJMS research communities. Given the interdisciplinary nature of the course, no single textbook will be used. Rather, clinically relevant research papers, review articles or specific book chapters (assigned by each lecturer) will be available for downloading at the RWJMS AMP website or via the Rutgers RWJMS Library website.

Grading:

Master’s students in the MSBS, MBS and PIB Programs: three multiple-choice type question exams each worth 1/3 of final grade.

Ph.D. students in Rutgers Molecular Biosciences Graduate Programs: three essay/short answer type question exams each worth 1/3 of final grade.

Grading Criteria: A: approximately top 25% B+: approximately second highest quarter B: Most of the remaining C+: Below average minus one standard deviation C: Below average minus 1.5 standard deviations F: Below average minus two standard deviations Course Objectives:

1. Understand the molecular and electrophysiological basis of neuronal synaptic transmission and muscle contraction. 2. Outline key human signaling factors and hormones, identify their cognate receptors, and understand the molecular and physiological signaling consequences of ligand-receptor interactions. 3. Discuss the molecular signaling mechanisms and pathways involved in peripheral sensory transduction (hearing, taste, vision, smell, pain). 4. Describe the process by which different types of human blood cells are generated and understand their respective functional roles in an immune or inflammatory response. 5. Understand the cellular signaling pathways utilized in humans to regulate and maintain cellular and physiological homeostasis. 6. Appreciate important animal model systems that are currently used by scientists to study human physiology and disease.

Lecturer Contact Information:

Name email phone

Joseph Fondell [email protected] 732-235-3348 Loren Runnels [email protected] 732-235-4593 Huaye Zhang [email protected] 732-235-3433 Harvey Weiss [email protected] 732-235-4626 Zhiping Pang [email protected] 732-235-8074 Huizhou Fan [email protected] 732-235-4607 John Pintar [email protected] 732-235-4250 Kelvin Kwan [email protected] 848-445-1781 Paul Breslin [email protected] 848-932-6080 Li Cai [email protected] 848-445-6559 Estela Jacinto [email protected] 732-235-4476 Samuel Bunting [email protected] 848-445-9894 Victor Jin [email protected] 732-235-4329 Martha Soto [email protected] 732-235-4424 Sunita Kramer [email protected] 732-235-4226 Hatem Sabaawy [email protected] 732-235-8081 Janet Alder [email protected] 732-235-5392 Smita Thakker-Varia [email protected] 732-235-5393 Rob Zachow [email protected] 732-235-5658 Course Schedule:

Topic Lecturer Date Course Introduction Fondell Tues. Jan. 24

I. Nerve and Muscle Physiology a. Membrane potentials/action potentials Runnels Tues. Jan. 24 b. Neurons and synaptic transmission Zhang Thur. Jan. 26 c. Ca2+ signaling and muscle contraction Weiss Tues. Jan. 31 d. Neuronal stem cells Pang Thur. Feb. 2 II. Hormones, Signal Transduction and Gene Expression a. TRP channels as cellular sensors Runnels Tues. Feb. 7 b. Opioid signaling Pintar Thur. Feb. 9 c. Growth factors/research paper discussion Fan Tues. Feb. 14 d. Nuclear Hormone Receptors/research paper discussion Fondell Thur. Feb. 16 EXAM I Tues. Feb. 21

III. Sensory Physiology a. Vision Cai Thur. Feb. 23 b. Taste Breslin Tues. Feb. 28 c. Audition/Hearing Kwan Thur. Mar. 2 d. Smell/olfaction Breslin Tues. Mar. 7 IV. Cellular and Physiological Homeostasis a. mTOR signaling/research paper discussion Jacinto Thur. Mar. 9 spring recess Tues. Mar. 14 spring recess Thur. Mar. 16 b. DNA repair/cell survival Bunting Tues. Mar. 21 c. Autophagy Jin Thur. Mar. 23 d. Microbiome Fan Tues. Mar. 28 self study Thur. Mar. 30 EXAM II Tues. Apr. 4 V. Pathophysiology of Metabolic Diseases a. Pathophysiology of Acid-Base disorders Zachow Thur. Apr. 6 b. Diabetes Mellitus Zachow Tues. Apr. 11 c. Diabetes Mellitus and Metabolic Syndrome Zachow Thur. Apr. 13 d. research paper discussion Zachow Tues. Apr. 18 VI. Animal Models to Study Human Physiology and Disease a. C. elegans Soto Thur. Apr. 20 b. Drosophila Kramer Tues. Apr. 25 c. Zebrafish Sabaawy Thur. Apr. 27 d. Mouse/research paper discussion Alder/Varia Tues. May 2 self study Thur. May 4

EXAM III Tues. May 9