Understanding the Right to Request Flexible Working s2

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Job Details Job Title: Postdoctoral research assistant School/Dept/Institute & Centre: William Harvey Research Institute, Centre for Translational Medicine & Therapeutics Reports to: Prof. Roger CORDER Grade: 4 Full Time/Part Time: Full-time Appointment period: 12 months Current Location: Charterhouse Square

Job Context

This post sits within the William Harvey Research Institute (WHRI) Bart’s and the London School of Medicine and Dentistry, part of Queen Mary, University of London. The WHRI has three core strategic themes: Inflammation, Cardiovascular and Endocrinology with a mix of basic scientists and clinicians benefitting from strong links with Bart’s and The London NHS Trust.

Funded by the BHF, the postholder’s main role will be to co-ordinate and drive a research project to identify the physiological endothelin-converting enzyme involved in the biosynthesis of endothelin-1. The project involves cell culture, use of ELISA, western blotting and protein purification/characterisation techniques, application of siRNA technology and mRNA measurements by qRT-PCR.

Job Purpose

A post-doc position is available to carry out the work described above and will include:

1. Planning and carrying out experimental work, devising strategies for further development and advancement of the project, and he/she will be involved in compiling the data, and writing manuscripts. 2. Contributing to the overall scientific endeavour of the research team and to take responsibility for areas of the current project. 3. Involved in defining and validating a drug target for enzyme inhibitor development. 4. Working as part of the research team, being mutually supportive and covering duties as necessary during colleagues’ absences and at times of additional pressure, as directed.

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Main Duties & Responsibilities

General Duties

1. Execute experiments in an accurate and reliable way. 2. Collect and analyse data. 3. Maintain appropriate databases, keeping accurate written and computerised records and to ensure that these records are stored in a secure place. To maintain confidentially of all electronically stored personal data in line with the provisions of the Data Protection Act. 4. Make research initiatives and original contributions to the research programme wherever possible, and to contribute freely to the team research environment in a manner conducive to the success of the research project as a whole. 5. Prepare reports and scientific publications to disseminate results from the programme of research. 6. Attend and participate in the academic activities of the Centre for Translational Medicine and Therapeutics, e.g. laboratory and journal club meetings. 7. Undertake literature searches to explore potential research projects, and to be able to interpret and present the findings of the literature searches and advise the research team appropriately regarding potential projects. 8. Supervise and train where necessary new members of the research team. 9. Ensure that the research project complies with ethics regulations. 10. Assist in drafting budgets and applications for potential research projects and grants. 11. Keep up to date with scientific, clinical and professional issues, in particular developments in the specific subject area. 12. Undertake certain communal laboratory responsibilities (including washing and cleaning duties), the nature of which will be discussed and agreed prior to commencement of the post, but which may need to be changed from time to time during the course of the project. 13. Show a professional attitude to matters of laboratory hygiene, organisation and safety, and to observe and to take an active role in fulfilling all statutory health and safety regulations.

Other 1. Ensure that all research is undertaken according to Good Clinical Practice (GCP), Good Laboratory Practice (GLP), and University’s protocols. 2. Ensure they are fully aware of and comply with the University’s policies and procedures in relation to confidentiality, health and safety at work, COSHH regulations, infection control, safe handling of drugs, and all local safety rules regarding fire, chemical, radioisotope and gene manipulation hazards. 3. The post holder must at all times carry out their responsibilities with due regard to the University’s Equal Opportunities policy. 4. The duties of the post outlined above are not exhaustive, and the post holder will be expected to be co-operative and flexible, undertaking such administrative and other duties as may from time to time be reasonably expected of a member of research grade staff in a university.

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The above list of responsibilities is not exhaustive and the jobholder may be required to undertake other duties commensurate with the level of the role, as reasonable requested by their line manager.

This job description sets out the duties of the post at the time it was drawn up. Such duties may vary from time to time without changing the general character of the duties or level of the responsibility entailed. Such variations are a common occurrence and cannot in themselves justify a reconsideration of the grading of the post.

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This table lists the essential and desirable requirements needed in order to perform the job effectively. Candidates will be shortlisted based on the extent to which they meet these requirements.

Knowledge, Skills & Experience (work experience, qualifications, specialist training, key skills, disposition)

Requirements Essential/Desirable

Qualifications Graduate in relevant biological sciences (minimum upper E second class honours degree). PhD in biochemistry, cell biology, pharmacology, or a E related scientific area.

Experience Experience of cell culture. E

Familiarity of immunoassay using ELISA methods. D

Experience of protein purification techniques, and protein D target identification by proteomic methods, and western blot characterisation/identification of proteins.

Experience of general molecular biology techniques (e.g. D mRNA purification, quantitative RT-PCR), and application of siRNA technology for confirmation of protein function.

Demonstration of scientific ability and excellence by D means of authorship (first author) peer reviewed publications in internationally recognised scientific journals. Knowledge, Good understanding of cell biology in relation to protein E skills & synthesis, intracellular processing and secretion. abilities Good understanding of gene expression and its regulation, cell signalling, and molecular biology. D A proven ability to manage other staff or students on a day-to-day basis. E Computer literate, and able to undertaken data processing and management. E Excellent interpersonal skills and communication skills. Ability to work independently and as part of a team. Good presentation skills. E E

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E – Essential: Requirements without which the job could not be done. D – Desirable: Requirements that would enable the candidate to perform the job well. William Harvey Research Institute 2016-17

Education Co-Directors Institute Management Patricia McGettigan Lead Mark Caulﬁeld & Amrita Ahluwalia Gerald McLarenLead Paul Chapple PGR Deputy Directors Steven Coppen Deputy Nina Ravic Manager Costantino Pitzalis & Márta Korbonits Nick Goulding Director of Academic Development

Inﬂ ammation Cardiovascular Endocrine CiTI NIHR CVBRC

Experimental Biochemical Microvascular Translational Clinical NIHR Endocrinology Medicine & Pharmacology Research Medicine & Pharmacology Advanced Rheumatology Therapeutics Imaging

Marelli-Berg Nourshargh Thiemermann Tinker Peterson Chapple Pitzalis D’Acquisto Suzuki Hobbs Munroe Pugliese Korbonits Bombardieri Perretti Whiteford Yaqoob Caulﬁeld Drak e Dell’Accio Goulding Henson Corder Ahluwalia Dunkel Eldin El Shikh Nissim Nightingale Solito Deloukas King Humby Cooray Hinds Johnston Shoulders Lewis Cooper (ARUK) Pearse (NIHR) Mathur Metherell Morrissey (NIHR) Aksoy O’Dwyer Brown Storr Mageed Longhi (BHF) Warner McGettigan Druce Mauro (BHF) Timmis Xiao Guasti Norling (ARUK) Schilling Turnbull Charalambous) Haworth (ECR) Smedley Gaston-Massuet Carvalho Chan (MRC)

Lipid Mediator Unit Lead Jesmond Dalli

Clinical Activities (Car diovascular, Respiratory, Endocrine, Musculoskeletal, Renal, Anaesthetics and Critical Car e), Arthritis Research UK Experimental Arthritis Centr e, WHRI Clinical Research Centre, Barts Cardiovascular CTU