And Experimental Therapeutics s1

The Journal of PHARMACOLOGY And Experimental Therapeutics

A Publication of the American Society for Pharmacology and Experimental Therapeutics

December 2007 Vol. 323, No. 3 Contents

PERSPECTIVES IN PHARMACOLOGY M. Joyeux-Faure 759 Cellular Protection by Erythropoietin: New Therapeutic Implications?

BEHAVIORAL PHARMACOLOGY Y. Zhao. G. R. Valdez, E. M. Fekete, 846 H Subtype-Selective Corticotropin-Releasing Factor Receptor J. E. Rivier, W. W. Vale, K. C. Rice, F. Weiss, and E. P. Zorrilla Agonists Exert Contrasting, but Not Opposite, Effects on Anxiety-Related Behavior in Rats

CARDIOVASCULAR Anna Tavridou, Loukas Kaklamanis, 794 Apostolos Papalois, Angeliki P. Kourounakis, EP2306 [2- (4-Biphenyl) -4-methyl-octahydro-1,4-benzoxazin-2- Eleni A. Rckka, Panos N. Kourounakis, Avgui ol, hydrobromide], A Novel Squalene Synthase Inhibitor, Charalambous, and Vangelis G. Manolopoulos Reduces Atherosclerosis in the Cholesterol-Fed Rabbit Mahmood Khan, lyyapu K. Mohan, 813 Vijay Kumar Kutala, Damodar Kumbala, and Cardioprotection by Sulfaphenazole, a Cytochrome P450 Periannan Kuppusamy Inhibitor: Mitigation of Isehemia-Reperfusion Injury by G. J. Rodrigues, C. B. Restini, 831 Scavenging of Reactive Oxygen Species C. N. Lunardi, J. E. Moreira, R. G. Lima, R. S. da Silva, and L. M. Bendhack Caveolae Dysfunction Contributes to Impaired Relaxation Induced by Nitric Oxide Donor in Aorta from Renal Chiari Kojima, Akio Kawakami, 855 Hypertensive Rats Takashi Takei, Kosaku Nitta, and jg] Angiotensin-Converting Enzyme Inhibitor Attenuates MasayukJ Yoshida Monocyte Adhesion to Vascular Endothelium through Shirley Wee, Jason N. Peart, and 861 Modulation of Intracellular Zinc John P. Headrick P2 Purinoceptor-Mediated Cardioprotection in Ischemic- Brett Burstein, Ange Maguy, 916 Reperfused Mouse Heart Robert Clement, Hugues Gosselin, Francine Poulin, Nathalie Ethier, Jean- Effects of Resveratrol (^ans-3,5,4'-Trihydroxystilbene) Claude Tardif, Terence E. Hebert, Treatment on Cardiac Remodeling following Myocardial Angelino Calderone, and Stanley Nattel Infarction Emilie Carrier, Isabelle Brochu, 972 Artur J. de Brum-Fernandes, and Pedro D'Orleans-Juste The Inducible Nitric-Oxide Synthase Modulates Endothelin-1- Dependent Release of Prostacyclin and Inhibition of Platelet Aggregation ex Vivo in the Mouse Robert T. Kinobc, Yanbin Ji, 763 CELLULAR AND MOLECULAR Jason Z. Vlahakis, Roberto Motterlini, Effectiveness of Novel Imidazole-Dioxolane Heme Oxygenase James F. Brien, Walter A. Szarek, and Inhibitors in Renal Proximal Tubule Epithelial Cells Kanji Nakatsu Long-Term Changes in the Muscarinic M1 Receptor Induced Kayla C. De Lorme, Marianne K. O. Grant, 868 by Instantaneous Formation of Wash-Resistant Xanomeline- Meredith J. Noetzel, Sonya B. Poison, and Receptor Complex Esam E. El-Fakahany An 80-Amino Acid Deletion in the Third Intracellular Loop of Geroid Bongers, Kathleen M. Krueger, a Naturally Occurring Human Histamine H3 Isoform Confers Thomas R. Miller, John L. Baranowski, Pharmacological Differences and Constitutive Activity Brian R. Eslvander, David G. Witte, Marina I. Strakhova, Peter van Meer, Remko A. Bakker, Marlon D. Cowart, Arthur A. Hancock, Timothy A. Esbenshade, and Rob Leurs Impaired Dexamethasone-Mediated Induction of Tryptophan Mingxiang Liao, Michael K. Pabarcus, 979 2,3-Dioxygenase in Heme-Deficient Rat Hepatocytes: YongQiang Wang, Colleen Hefner, David A. Translational Control by a Hepatic eIF2a Kinase, the Heme- Maltby, Katalin F. Medzihradszky, Saida Regulated Inhibitor Patricia Salas-Castillo, James Yan, Jacquelyn J. Maher, and Maria Almira Correia

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL Comparative Protection against Liver Inflammation and Raquel Horrillo, Anna Planaguma, Ana 778 Fibrosis by a Selective Cyclooxygenase-2 Inhibitor and a Gonzalez-Pe'riz, Natalia Ferre\ Esther Nonredox-Type 5-Lipoxygenase Inhibitor Titos, Rosa Miquel, Marta Lopez-Parra, Jaime L. Masferrer, Vicente Arroyo, and Joan Claria

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS Angiopoietin-Related Growth Factor Suppresses Masashi Kitazawa, Yasushi Ohizumi, 787 Gluconeogenesis through the Akt/Forkhead Box Class Ol- Yuichi Oike, Takanori Hishinuraa, and Dependent Pathway in Hepatocytes Seiichi Hashimoto Pharmacogenetics of Deoxycytidine Kinase: Identification and Jatinder K. Lamba, Kristine Crews, 935 Characterization of Novel Genetic Variants Stanley Pounds, Erin G. Schuetz, Jessica Gresham, Varsha Gandhi, William Plunkett, Jeffrey Rubnitz, and Raul Ribeiro

NEUROPHARMACOLOGY Phosphatidylinositol 3-Kinase/Akt Quantification of Phosphorylated cAMP-Response Element- Cameron Binding Protein Expression throughout the Brain of S. Amphetamine-Sensitized Rats: Activation of Hypothalamic McPhers Orexin A-Containing Neurons on, l-(3',4'-Dichloro-2-fluoro[l,l'-biphenyl]-4-yl)- Travis cyclopropanecarboxylic Acid (CHF5074), a Novel y-Secretase Featherb Modulator, Reduces Brain ^-Amyloid Pathology in a y, Elena Transgenic Mouse Model of Alzheimer's Disease without Krstew, Causing Peripheral Toxicity and Andrew J. Lawrenc Anxiolytic-Like Effects of K-Opioid Receptor Antagonists in e Models of Unlearned and Learned Fear in Rats

Neuroprotective Effects of Glyceryl Nonivamide against Bruno P. Microglia-Like Cells and 6-Hydroxydopamine-Induced Imbimbo Neurotoxicity in SH-SY5Y Human Dopaminergic , Elda Neuroblastoma Cells Del ST91 l2-(2,6-Diethylphenylamino)-2-imidazoline Giudice, Hydrochloride]-Mediated Spinal Antinociception and Synergy Davide with Opioids Persists in the Absence of Functional a-2A- or Colavito, a:-2C-Adrenergic Receptors Antonell o Negative Allosteric Modulation of Nicotinic Acetylcholine D'Arrigo Receptors Blocks Nicotine Self-Administration in Rats , Maurizio Dalle TASK-3 Knockout Mice Exhibit Exaggerated Nocturnal Carbonar Activity, Impairments in Cognitive Functions, and Reduced e, Gino Sensitivity to Inhalation Anesthetics Villetti, Fabrizio Facchine Chondroitin Sulfate Protects SH-SY5Y Cells from Oxidative tti, Stress by Inducing Heine Oxygenase-1 via Roberta Volta, Vladimiro Pietrini, Maria F. Baroc, Lutgarde Serneels, Bart De Strooper, and Alberta Leon 805 Allison T. Knoll, Edward G. Meloni, James B. Thomas, F. Ivy Carroll, and William A. Carlezon Jr. Yi-Chin Lin, Hao-Wei Uang, Rong-Jyh Lin, Ing-Jun Chen, and Yi- Ching Lo 822

Laura S. Stone, Kelley F. Kitto, James C. Eisenach, Carolyn A. Fairbanks, and George L. Wilcox

Ryan F. Yoshimura, Derk J. Hogenkamp, Wen Y. Li, Minhtam B. 838 Tran, James D. Belluzzi, Edward R. Whittemore, Frances M. Leslie, and Kelvin W. Gee Anni-Maija Linden, Cristina Sandu, M. Isabel Aller, Olga Y. 877 Vekovischeva, Per H. Rosenberg, William Wisden, and Esa R. Korpi Noelia Cafias, Teresa Valero, Mercedes Villarroya, Eulalia Montell, Josep Verges, Antonio G. Garcfa, and Manuela G. Lopez 899

946 Pharmacological Interaction between 3,4- Magi Farre, Sergio Abanades, Pere N. Roset, Methylenedioxymethamphetamine (Ecstasy) and Paroxetine: Pharmacological Effects and Pharmacokinetics 954 Ana M. Peiro, Marta Torrens, Control of Glycinergic Input to Spinal Dorsal Horn Neurons Bryan O'Mathuna, Mireia Segura, and by Distinct Muscarinic Receptor Subtypes Revealed Using Rafael de la Torre Knockout Mice Hong-Mei Zhang, Hong-Yi Zhou, Deletion of jn-Opioid Receptor in Mice Alters the Development of Acute Neuroinflammation 963 Shao-Rui Chen, Dinesh Gautam, Jilrgen Wess, and Hui-Lin Pan Khalid Benamar, Menachem Yondorf,

990 Veronica T. Barreto, Ellen B. Geller, and Martin W. Adler

TOXICOLOGY Effect of Arylhydroxylamine Metabolites of Sulfamethoxazole Farah D. Khan, Piyush M. Vyas, and Dapsone on Stress Signal Expression in Human Keratinocytes 771 Anthony A. Gaspari, and Craig K. Svensson