The Genetic Variability of Telomere Associated Proteins (Telomerases and Shelterins) Has

Table 1 SM. Association results between the analyzed polymorphisms and the telomere length obtained in a subgroup of 457 (46.4%) randomly selected subjects from the analyzed sample.

SNP Gene Chr Position in the genome Mean difference Lower Upper P-value rs2736100 TERT 5 1339516 -0,1418 -0,2485 -0,03502 0,00958113 rs11639771 TERF2_IP 16 74249153 0,1732 0,0253 0,3211 0,02218002 rs3784929 TERF2_IP 16 74234528 -0,1888 -0,3544 -0,02329 0,02587082 rs10107605 TERF1 8 74104911 -0,1403 -0,2702 -0,01045 0,0347525 rs12696304 TERC 3 170963965 -0,1132 -0,2264 -2,65E-05 0,0505812 rs2736098 TERT 5 1347086 0,1009 -0,01919 0,221 0,10034253 rs10078761 TERT 5 1302594 -0,07738 -0,1884 0,03365 0,17265948 rs12334686 TERF1 8 74099005 0,06879 -0,04394 0,1815 0,23233192 rs2853669 TERT 5 1348349 0,06508 -0,0492 0,1793 0,26499898 rs1760904 TEP1 14 19921869 -0,05997 -0,1668 0,04685 0,27180387 rs4246977 TEP1 14 19952431 -0,05889 -0,1669 0,0491 0,28574056 rs2853676 TERT 5 1341547 0,05776 -0,06234 0,1779 0,34646622 rs2233807 TERF2_IP 16 74238769 -0,07456 -0,2314 0,08224 0,35189267 rs1760890 TEP1 14 19951629 0,07596 -0,09175 0,2437 0,37516718 rs2975842 TERF1 8 74088145 -0,04597 -0,1536 0,06169 0,40311442 rs2242652 TERT 5 1333028 0,05423 -0,07831 0,1868 0,42298129 rs4246742 TERT 5 1320356 -0,06691 -0,2309 0,09703 0,4241757 rs2853691 TERT 5 1305950 0,04942 -0,07623 0,1751 0,44119882 rs2736122 TERT 5 1310621 0,05191 -0,09294 0,1968 0,48281073 rs2066276 TNKS2 10 93547599 -0,03839 -0,1532 0,07639 0,51248997 rs10509637 TNKS2 10 93577712 -0,05092 -0,205 0,1032 0,51751152 rs938886 TEP1 14 19907541 -0,03286 -0,1581 0,09234 0,60726223 rs12335203 TERF1 8 74116173 0,03156 -0,08939 0,1525 0,60930963 rs2929586 TERF1 8 74087966 0,03018 -0,09862 0,159 0,6462806 rs7845139 TERF1 8 74124181 0,02994 -0,09795 0,1578 0,64654699 rs2075786 TERT 5 1319310 -0,01954 -0,1329 0,09387 0,73579132 rs1760897 TEP1 14 19946093 -0,01438 -0,1319 0,1031 0,81048249 rs6982126 TERF1 8 74102177 0,01504 -0,1118 0,1419 0,8164153 rs3785074 TERF2 16 67964487 -0,006696 -0,1259 0,1125 0,91238284 rs6990097 TNKS 8 9450267 -0,003866 -0,1393 0,1316 0,95541495 rs4975605 TERT 5 1328528 0,002703 -0,1068 0,1122 0,96143429

For each SNP, mean difference and its 95% confidence interval (Lower/Upper) among the observed genotypes is displayed. The most frequent homozygous genotype was considered as the reference category assuming an log-additive model.

The genetic variability of telomere associated proteins (telomerases and shelterins) has a complex effect on human longevity AGE Paolina Crocco, Roberto Barale, Giuseppina Rose, Cosmeri Rizzato, Aurelia Santoro, Francesco De Rango, Maura Carrai, Paola Fogar, Daniela Monti, Fiammetta Biondi, Laura Bucci, Rita Ostan, Federica Tallaro, Alberto Montesanto, Carlo-Federico Zambon, Claudio Franceschi, Federico Canzian, Giuseppe Passarino, Daniele Campa

Corresponding Authors Giuseppe Passarino Department of Biology, Ecology and Earth Science University of Calabria 87036 Rende-Italy Tel. + 390984492932; Email [email protected]

Daniele Campa Department of Biology, University of Pisa, 56126 Pisa- Italy Tel. +39 050 2211510; Email: [email protected]