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M E T A B O L I S M

Course code: 13.1-WB-B2M-META Type of course: compulsory Language of instruction: English Director of studies: dr hab. Ewa Jaśkiewicz dr hab. Ewa Jaśkiewicz, Name of lecturer: Beata Machnicka PhD s s r r r u u e o o r t k h h e s e

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Type of course Course grade

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Full-time studies

Lecture 30 2 Exam 7 I Laboratory 30 2 Credit assessment

AIM OF THE COURSE: Aim of the course The main objectives of the course: - to be able understand and apply the methods used in metabolic studies, - to gain understanding of the localization, regulation and integration of metabolic pathways and molecular basis of human metabolic diseases.

PREREQUISITES: Principial knowlege in physical chemistry: chemical equilibrium, entropy and laws of thermodynamics. Enzymes – principles and kinetics.

SCOPE: Principles of metabolism. Glycolysis and gluconeogenesis are regulated contrary. The citric acid cycle regulation. Regulation of oxidative phosphorylation. The pentosephosphate pathway regulation. Coordinated regulation of glycogen synthesis and breakdown. Fatty acids metabolism regulation. Regulation of biosynthesis of lipids and steroids. Amino acids biosynthesis is under allosteric regulation. Regulation of biosynthesis and degradation of nucleotides. Integration of mammalian metabolism: - key metabolites, - tissue specific metabolism, - glucose homeostasis during fasting , starvation and satiation.

METHODS OF EDUCATION: Lecture (in a form of multimedia presentation) - Practical method – laboratory classes with the use of Saccharomyces cerevisiae mutants as a model organism and microbiological equipment.

Faculty of Biology FCEE - offer in English – WPISZ Subject area of studies: LEARNING OUTCOMES. SYMBOLS VERIFICATION FORM OF DESCRIPTION OF THE EFFECT OF METHODS CLASSES EFFECTS Posseses the knowledge of P2A_W01 Grade lecture metabolic pathways and P2A_W04 understands its regulation and integration. Possesses the knowledge of usage P2A_W07 Practical work, Lecture laboratory equipment and applies P1A_W09 Grade laboratory the ergonomic principles of work in biochemical laboratory. Is able to use the literature and other P1A_U02 Practical work, Lecture, sources (elearning) in polish and P1A_U03 Grade laboratory english language, to interpret the K1A_U02 results and draw the conclusions. Plans and carries out experiments, is P2A_U01 Practical work, laboratory able to apply the research methods P2A_U06 Grade and technics, applies acquired skills in work environment. Works in a group and organize the P1A_K02 Practical work, laboratory activities in a specified range K1A_K02 Grade Can prepare an oral presentation P2A_U08 Practical work, Lecture, and write a research report in polish. P2A_U09 Grade laboratory Applies self-study method and P2A_K05 Practical work, Lecture, understands the need to master P2A_K07 Grade laboratory knowledge and skills in biochemistry.

VERIFICATION OF LEARNING OUTCOMES AND CREDIT CONDITIONS: The lectures- the final examination test after getting the pass mark credit of the classes. It is conducted in the written form, it lasts 60 minutes and contains 30 open questions. 60% of the points out of 60 are required to get the pass mark credit. The laboratory classes: the attendance at classes, the laboratory experiments carried out correctly and the pass mark credit of 2 tests (the first 20 questions test, 60% of the points out of 20 are required to get the pass mark credit, the second 3 open questions test, 60% of the points out of 9 are required to get the pass mark credit.

STUDENT WORKLOAD:

Workload Full-time studies The contact hours 66 The unassisted student work 140 In all 206 ECTS Points

Classes with the participation of academic teacher 3 Classes without the participation of an academic teacher 4 In all 7