Table S1. Results of Protein Pathway Array Analysis

Table S1. Results of protein pathway array analysis.

FIRST RUN SSM NM Proteins WM 35 WM1575 WM1552C WM 983e WM 98.1 WM3248 p-PKCα 2567.77635 2587.9531 2772.340367 382.8003369 1800.186874 2292.475 FAS 1350.338194 15877.41646 1972.494364 310.519663 422.5898486 1975.5766 p-PDK1 6409.598601 457453.8537 8194.462344 6591.400138 5906.313435 7569.623 p-PKC α/βII 548.3716616 123138.7179 1389.247274 294.4489011 979.5124484 856.78108 p-AKT 979.6730822 28209.9939 625.5531916 812.4364693 516.3248457 586.95057 p-PTEN 7857.509777 1090354.729 6444.746776 8803.356117 7020.002619 7183.2410 p-RB (Ser780) 4339.622709 570714.6654 3997.625145 3082.746498 2725.577048 3601.0500 p-Stat5 88.11841397 21095.66465 306.0273484 291.5399012 719.0731565 34.400153 p-stat3 627.5431136 184225.7303 1099.763605 640.1224304 644.9268868 985.3604 p-ERK 6039.639087 647216.5653 4952.121831 11682.10878 10215.91131 6017.2472 p-GSK-3α/β 1253.213103 63479.35888 934.7087989 546.5797234 1850.04786 1043.2087 p-p90RSK (Ser380) 926.259362 145360.3113 1840.06671 3058.197252 2286.972792 2827.393 MetRS 7110.495914 59514.4745 6757.085295 9687.710737 8636.739663 9399.7576 p-PKCδ 2062.936448 157928.5528 1633.824546 2230.161648 1856.272565 2034.0144 p-cdc2 382.7867727 36034.02206 547.5144832 789.7369193 147.2875543 166.3588 p-c-Jun 293.3057029 23870.81407 145.2543004 194.8298528 436.0235727 186.88639 p-Rb (Ser807/811) 1517.783501 195821.1911 1250.270637 3049.832572 1419.325106 2148.6385 Stat1 1115.118687 56291.07100 1485.084082 8537.48554 5172.629377 2002.1436 p-P38 181.7322756 18179.1524 1445.788453 456.9408023 533.0820795 690.52997 β-actin 16495.91419 5187645.89 16940.09532 7035.279549 13598.54162 14148.277 GAPDH 19581.98665 1717313.848 16897.30063 12935.09558 14111.08082 15324.111 cyclin B1 6419.881672 355281.4658 4661.666688 3925.440026 3368.503815 3762.5760 cyclin D1 510.3961062 56088.76130 383.531084 259.1560598 1100.840991 404.86123 Cdk6 1505.236119 108119.5999 2071.273129 672.2311121 2135.541825 2323.1212 Cdc25B 332.0296991 17727.52442 762.0764439 279.9376105 406.7969925 567.96339 cyclin E 461.7862198 190913.3000 397.4183662 1990.069549 1635.676718 1300.3544 cdk2 6376.560119 229652.1671 1054.76611 10826.01243 2096.923868 3830.6256 P27 69.83325942 61.4 044627 39.74823824 23.6995004 88.82909392 7.8862808 Cdk4 1.409378161 1.36044627 1.409565976 64.57692833 181.0484625 21.809051 14-3-3 Beta 1442.529143 213361.2326 697.9186075 2588.221091 4208.188209 3742.0230 ERK 537.696556 29738.50794 502.4606305 1003.635514 1460.814068 2075.4306 EGFR 1968.412024 16490.8987 864.247748 2011.303877 495.5618523 1746.8612 Cdc25C 83.5188147 18056.00817 57.41088875 149.7927402 121.2802578 230.36436 Hsp90 3222.40319 27901.9643 3633.2803 1802.859895 1251.907643 1428.6711 cdc2 p34 4916.719812 495155.9057 4401.459611 6645.183407 3383.867788 2951.1133 PCNA 22535.7465 1398232.575 11472.57532 11889.54215 18409.2598 9087.5975 Rap 1 6477.243348 4133184.86 20608.90284 12227.37182 5384.224689 14662.137 beta-catenin 20.37023206 36339.14317 190.2855759 297.8460798 367.890268 468.21223 Akt 218.7510495 5930.46436 914.1701112 1438.73499 1505.827527 2207.9319 XIAP 2210.186437 310213.2931 5301.596904 2721.114673 5707.196218 5635.619 Bcl-2 1.409378161 11.3 044627 22.36202129 1.031483417 1.256739758 166.05177 patched 41.80864402 673.6492081 167.0458995 649.4685192 275.2668024 248.5385 HIF-2α 184.1966077 92083.70417 1067.866537 235.8664564 604.6379562 1512.9859 85 TTF-1 33.13851464 117.2094687 299.3671693 170.4852201 356.2418817 475.8413042 p53 83.5549429 54.35020119 107.6501729 59.48652677 196.3024064 197.4799074 PTEN 2595.710047 1935.653385 156.400581 1532.706528 214.5100187 167.6213356 SRC-1 (M-341) 141.1328499 133.3070665 141.9621597 117.6483018 369.8232116 100.8022498 HIF-3α 888.4955403 896.0673487 676.4199933 1390.578856 508.1704434 1452.876718 Bax 11.6731315 232.4844084 11.60145728 52.74757221 206.5846635 76.67688404 cdc42 0.841465527 49.38280713 40.75116199 140.4341102 9.946905383 0.92121745 eIF4B 122.4636564 190.445047 107.0046641 182.0866931 199.1995458 71.42816876 E-cadherin 94.79787149 337.7610227 187.553415 354.2011009 564.0528523 326.8719846 Erb (H-150) 1103.119612 832.0409249 1236.427098 545.2009178 489.3741283 463.5458192 WT1 14881.08189 13338.57963 20598.79928 15970.82575 13829.84111 11592.34956 Mesothelin 3476.53247 1204.616103 3516.869099 3241.565431 2940.623859 3231.715769 NFkB50 867.781454 510.1866692 527.3300518 1078.963441 1018.655704 1448.996176 Calretinin 10223.11061 5742.611656 4227.991052 10913.84156 1797.665198 9673.039947 IL-1β 117.6476211 47.16999395 1.516167685 0.796493266 2390.684583 136.7043107 H-Ras 513.7536864 470.1359093 1146.666337 695.3767778 1398.593288 962.4261126 Bcl-6 86.26884237 67.07595509 130.0059816 228.6349855 216.3128527 131.1544916 NFkB p65 223.8218741 613.5922399 223.7334479 286.1878043 486.3352499 454.5879497 CREB 317.00282 513.1109628 191.0901902 200.4733508 303.7150712 222.5902179 β-actin 350.0935205 1099.860222 458.4827919 322.3796731 569.4590201 781.3885036 GAPDH 7325.554842 15126.80246 9760.278884 6086.234459 15827.33611 12045.1864 ICAM-1 2593.758751 382.7981114 6738.764698 8076.999452 9367.385742 10847.98957 Estrogen Receptor α 168.699284 7.724747895 249.3267159 387.4555673 64.18611201 877.590172 PSM 8053.79951 3318.600221 5646.051748 3067.822821 5326.218249 4797.677463 Rab 7 862.3947138 305.4668174 81.38117741 645.8498973 568.895627 309.3976881 VCAM-1 117.8024409 71.05551943 59.9965586 24.43471305 52.42697618 53.90541234 FGF-8 276.2214878 797.0817181 1408.342287 470.7135265 549.1395668 448.6989481 NEP 120.7109403 266.6756092 139.0985825 436.0760582 86.72476934 128.3064198 Bcl-xL 3096.17523 7873.108122 4971.699002 3686.637487 3254.072992 3716.42073 Bak 1997.693577 5197.009517 7335.177207 6550.654667 6990.870532 7944.480262 TFIIH p89 22051.0263 12362.70119 9149.507758 15131.81961 9478.792683 9623.413529 Nkx-3.1 2773.01589 896.3304332 3542.200386 3086.570547 1475.009083 2431.084671 RIP 4398.094728 1608.706291 2017.917264 2301.644681 5850.4787 2855.461442 NM23 880.0034592 3528.507872 1625.27051 2122.331003 2308.360228 1801.49863 Epo 407.6512785 454.0456898 460.1225139 1122.090036 551.48292 467.8335944 stat 3 799.2457697 2493.003618 1710.42358 1846.676598 2745.264887 1620.955587 ERCC1 414.7095403 295.0080918 802.2843672 468.0201833 739.5059627 222.6130125 uPAR 747.3809139 4336.704223 1139.07845 1409.99309 1861.643413 1079.547832 KAI1 4.584583765 70.67160697 108.7885482 9.61725602 153.3695687 13.24459729 L-Selectin 416.737021 865.5008504 1224.257371 1150.276254 942.1666824 1371.719325 E-Selectin 19.62004665 180.0299055 195.0867412 1742.333036 969.1876977 408.9461368

SECOND RUN SSM NM Proteins WM 35 WM1575 WM1552C WM 983e WM 98.1 WM3248 p-PKCa 1377.722508 2518.250744 3030.473928 501.6593712 1897.269884 1744.529375 FAS 741.9799678 1308.447541 1563.126506 652.7775114 342.4117951 922.715316 p-PDK1 4011.056926 4679.311409 4818.192759 3662.466443 5088.065958 4406.373481 p-PKC α/βII 792.8295327 1108.775364 1498.19474 211.0832545 891.1868821 544.9668339 p-AKT 956.3947076 936.1603568 198.6683227 697.4101469 404.4180697 459.9841526 p-PTEN 6332.080537 6704.066779 5724.626086 5625.787417 5861.929442 5153.298794 p-RB (Ser780) 1829.154301 1769.894719 1446.21452 1419.9131 1279.452714 850.8805835 p-Stat5 338.2089802 520.0781795 212.9746541 296.0027326 522.3883394 218.3312958 p-stat3 556.8697791 1164.651702 521.4638984 526.1947513 444.4333628 853.5699927 p-ERK 15694.27888 8296.114132 17844.19047 24874.65409 14320.64704 17516.25419 p-GSK-3α/β 1154.859287 971.1831244 937.3177673 780.2735009 1296.197332 1108.951435 p-p90RSK (Ser380) 4047.806442 3681.81367 3464.165557 5212.108228 4683.378849 4659.472216 MetRS 7224.190929 5224.117819 5153.143106 3596.045874 5992.993596 5415.460796 Lyn 679.0917479 377.0791284 292.1363091 305.3750613 378.5583888 524.9658355 CaMKKa 2047.752206 1668.91173 1061.861751 1126.025903 1399.198172 1759.99299 p-c-Jun 261.6116193 1123.581625 315.0428981 725.4005914 297.8898545 433.6244926 p-Rb (Ser807/811) 623.9842228 610.2910875 633.1214129 829.8765256 545.2861186 597.394257 SK3 (H-45) 1396.227973 982.2823287 576.7205963 493.7211803 779.1324958 895.6416426 p-P38 2390.867952 847.3893764 2252.654789 3708.156282 3892.377677 1635.235253 β-actin 73.54212877 1352.879141 1536.38046 1000.223694 600.644063 1299.747218 GAPDH 16511.63204 19444.63422 16103.31499 14453.2329 16440.33575 15919.3024 cyclin B1 12962.2039 16714.43239 12820.36104 11305.95801 14646.15079 15083.65401 cyclin D1 1431.535935 1409.55425 1015.466967 1605.907408 1206.104373 727.0080345 Cdk6 1709.220337 1889.48671 1802.572278 945.0528967 1864.876586 1284.259777 Cdc25B 2017.209677 2966.403187 4254.555546 871.2864887 3219.14069 3162.492721 cyclin E 203.8882887 204.2065222 917.9074568 164.5393947 273.2896777 478.5185332 cdk2 2845.982214 775.6961787 4089.230102 5373.544984 2531.714917 4462.398149 p27 7133.028071 4667.634893 2864.107354 9859.93924 3007.672785 4574.585562 HER2 382.3636634 68.14246505 61.09643633 87.59959263 118.3395069 90.03755587 Cdk4 190.0419662 120.2327862 293.8487235 105.7284673 193.2093391 205.2698723 14-3-3 Beta 313.8558549 177.9583066 156.397081 118.7727134 220.4528003 143.6131394 cPKCα 2272.024967 2935.619801 1072.018254 2861.051231 2218.172255 4277.802662 ERK 6242.686267 7705.855035 10658.05236 1125.448805 5597.796775 7005.994618 EGFR 2500.473153 1739.85417 1778.784222 3139.981826 2743.812342 2471.206303 SLUG 524.0209379 2873.023649 2510.33101 38.74252202 526.3079509 46.10527695 Hsp90 372.8711638 322.1309191 201.5059151 278.623123 111.6431896 193.7018288 CHK1 5568.51538 4426.933961 5514.30827 6915.346049 5777.372829 4577.23107 E2F-1 1984.224579 1679.502423 934.1635467 1907.890971 1030.100798 799.3808855 p63 12957.33341 11028.27749 7808.177624 12588.11303 12299.96682 8889.856777 Rap 1 401.6587092 336.0718718 612.9535923 80.5377299 654.9864307 671.1409562 beta-catenin 2170.432747 3877.235618 3655.375805 3983.700785 1979.175003 3801.343321 Akt 121.0157253 348.712035 182.1591696 81.28568142 320.2366183 136.3414402 HCAM 1504.075327 1468.702435 1334.28355 1516.653724 3077.369129 2531.716376 Bcl-2 1981.907103 2676.88623 2016.886101 1272.094077 3366.102004 2437.409165 patched 0.881300696 210.5989443 16.46626828 4.204431797 6.839752653 188.8472144 HIF-1α 824.5415789 438.6232421 383.5582727 537.4582485 761.4757715 176.5018485 TTF-1 250.0136582 309.7486364 431.919968 405.0032278 18.46324942 180.2743449 p53 186.8038004 18.86077664 61.28938695 170.4817195 0.970214837 210.5980568 Notch4 188.0463268 145.8692653 47.15734412 83.21854259 0.970214837 92.02070864 SRC-1 (M-341) 2505.750929 2301.443247 141.1108777 1980.787978 647.0882797 409.501989 Eg5 (H-300) 1289.159044 1552.667368 1606.525819 1550.117782 2444.77693 939.1306944 Bax 1882.757089 524.6058821 1438.520347 676.5784608 604.3971821 747.2074713 N-cadherin 45.20441565 1.14397053 17.20063126 165.4521069 98.25601407 130.3346987 eIF4B 64.59718685 211.3003357 357.7245111 1.679538991 38.02366796 168.3181063 Vimentin 450.157329 445.1442498 413.179793 428.3309575 262.7578723 336.0050139 Osteopontin 262.3027465 147.2955969 377.5729095 257.2505203 180.178824 183.4621668 TGF-β 1.325131721 111.2470345 176.2637644 1.679538991 60.96027147 129.2248297 Mesothelin 3326.2561 2854.720797 3664.855136 3121.959133 5319.214877 4303.397452 VEGF 26.90585063 25.16059761 120.7805594 43.46312533 103.9045559 880.7161794 NFkB50 240.4349465 152.8595706 0.954803982 781.4248924 267.1618029 1910.034129 IL-1β 10285.61419 3250.929363 1822.757534 9728.564911 1109.339701 7414.609716 H-Ras 1.073988441 23.54462466 17.70981725 1.679538991 1175.529908 10.49485744 Bcl-6 478.7316423 658.4266388 238.9147043 771.7721471 484.3570065 1101.305751 K-Ras 794.9710208 365.4494148 584.3089916 860.8714356 284.7423636 456.9287047 alpha-tubulin 22.88026662 141.1024396 31.77320579 92.16535275 88.38497528 58.3764669 CREB 28.03497785 78.90940976 22.20379424 93.76023894 39.03905429 10.11263899 β-actin 149.6910127 87.73147503 9.51951953 127.0906362 0.89839104 0.912724213 GAPDH 5270.598007 5036.972412 7186.737956 7540.279547 4655.754959 5147.152901 BID 16214.43794 25370.22938 25112.26914 15115.97597 25476.11717 19003.65732 Estrogen Receptor α 6258.572989 829.400365 13890.17847 15397.72887 13447.93671 14303.86615 c-Flip 2.307818736 13.76848858 31.04781387 102.5335515 30.46196157 270.3842192 Rab 7 2937.209118 1539.131786 2334.511704 337.801543 1899.482673 1026.594685 VCAM-1 598.5809914 425.4937107 167.7254719 326.7336669 507.0292647 483.9292039 FGF-8 791.5929409 1306.556122 678.7194615 792.4385755 474.1872569 691.9729837 NEP 99.24979076 599.1942108 922.5222181 88.48800908 488.168148 262.9978945 Bcl-xL 118.7316117 107.9681781 32.49554003 889.3447704 237.6115055 66.61458985 Endoglin 293.7323457 1366.686347 432.410984 603.6334211 198.0387414 433.5630537 TFIIH p89 2177.744813 8824.364715 11491.03507 11767.59541 8834.091934 15314.74159 Nkx-3.1 32368.62154 16164.53408 9458.864386 13712.39195 18277.02104 10446.55074 RIP 277.8006667 380.7577437 396.2444621 400.5172263 163.0671959 434.0551395 NM23 952.4541078 1005.54901 496.250406 773.0329333 801.8928474 329.7196507 c-IAP2 1120.904165 2491.789641 266.1089005 1203.471379 560.1062412 2063.580534 uPA 82.82437483 656.0531414 186.9599514 389.4353203 360.2511576 466.7837821 ERCC1 3148.750189 3235.045147 2866.957758 2912.25714 3842.867303 2011.517015 uPAR 512.2629223 329.9881852 507.4036964 364.299566 523.404193 535.319626 KAI1 359.6321539 5137.095067 723.8498927 275.7004376 859.3990137 732.693688 L-Selectin 321.7608349 349.6787043 157.7904337 443.8716546 284.2361531 291.1643657 PSCA-1 2202.132668 3176.365215 1495.777747 1625.653911 1489.805308 2365.459537