Authorized Distributors of Record

Below is a listing of the Authorized Distributors of Record (ADRs) for Astellas Pharma US, Inc. and OSI Pharmaceuticals, LLC, in accordance with 21 C.F.R. § 203.50(d). If you have questions regarding this list, please contact [email protected].

Astellas Pharma US, Inc. Authorized Distributors of Record Name of ADR Address Products Covered Third Party Logistics Providers UPS Supply Chain Solutions, 12380 Morris Rd., Alpharetta, GA 30005 Entire Product Line* Inc. U.S. Wholesalers/Distributors AmerisourceBergen Drug 1300 Morris Dr., Chesterbrook, PA 19087 Entire Product Line (except Corporation Xtandi) Anda, Inc. 2915 Weston Road, Weston, FL 33331 Entire Product Line (except Xtandi) Burlington Drug Company, 91 Catamount Drive, Milton, VT 05468 Entire Product Line (except Inc. Xtandi) Capital Wholesale Drug 873 Williams Ave., Columbus, OH 43212 Entire Product Line (except Xtandi) Cardinal Health 7000 Cardinal Place, Dublin OH 43017 Entire Product Line (except Xtandi) Dakota Drug, Inc. 1101 Lund Blvd, Anoka, MN 55303 Entire Product Line (except Xtandi) DMS Pharmaceutical Group, 810 Busse Hwy., Park Ridge, IL 60068 Entire Product Line (for Inc. Xtandi, ADR for FSS customers only) F.W. Kerr Company, Inc. 43155 W. Nine Mile Road, PO Box 8026, Entire Product Line (except Novi, MI 48376-8026 Xtandi) Harvard Drug Group, L.L.C. 31778 Enterprise Dr., Livonia, MI 48150 Entire Product Line (except Xtandi) H.D. Smith, LLC 3063 Fiat Avenue, Springfield, IL 62703 Entire Product Line (except Xtandi) Louisiana Wholesale Drug 2085 I-49 S. Service Road, Saint Charles Entire Product Line (except Co., Inc. College Service Entrance, Sunset, LA Xtandi) 70584 McKesson Corporation One Post Street, San Francisco, CA 94104 Entire Product Line (except Xtandi) Miami-Luken, Inc. 265 S. Pioneer Blvd., Springboro, OH Entire Product Line (except

* Astellas Pharma US, Inc.’s product line consists of the following products: Adenocard®, AmBisome®, Astagraf XL®, Lexiscan®, Mycamine®, Myrbetriq®, Prograf®, VESIcare®, Cresemba®, and Xtandi®. Updated 10/01/2016 Name of ADR Address Products Covered 45066 Xtandi) Morris & Dickson Company, 410 Kay Lane, Shreveport, LA 71115 Entire Product Line (except L.L.C. Xtandi) N.C. Mutual Wholesale Drug 816 Ellis Road, Durham, NC 27703 Entire Product Line (except Co. Xtandi) Pharmacy Buying Association 6300 Enterprise Road, Kansas City, MO Myrbetriq, Prograf, & 64120 VESIcare Prescription Supply, Inc. 2233 Tracy Rd., Northwood, OH 43619- Entire Product Line (except 1326 Xtandi) Rochester Drug Cooperative, 50 Jet View Drive, Rochester, NY 14624 Entire Product Line (except Inc. Xtandi) Smith Drug Company, Inc. 9098 Fairforest Road, Spartanburg, SC Entire Product Line (except 29301 Xtandi) Valley Wholesale Drug Co., 1401 West Freemont St., Stockton, CA Entire Product Line (except Inc. 95203 Xtandi) Value Drug Company, Inc. 195 Theater Drive, Duncansville, PA 16635 Entire Product Line (except Xtandi) Non-U.S. Wholesalers/Distributors Cesar Castillo, Inc. Road # 1 KM 21.1 Sector La Muda, Entire Product Line (Puerto Guaynabo, Puerto Rico 00970 Rico & U.S. Virgin Islands) U.S. Specialty Distributors Oncology Supply 2811 Horace Shepard Drive, Dothan, AL Xtandi 36303 Besse Medical 9075 Centre Pointe Dr., Ste. 140, West Lexiscan & Xtandi Chester, OH 45069 Cardinal Health 108, LLC., 305 Tech Park Drive, Suite 11, La Vergne, Xtandi d/b/a Cardinal Health SPD TN 37086 Henry Schein, Inc. 135 Duryea Road, Melville, NY 11747 Lexiscan & Xtandi McKesson Medical-Surgical, 9954 Mayland Drive, Suite 4000, Lexiscan Inc. Richmond, VA 23233 McKesson Plasma and 401 Mason Road, La Vergne, TN 37086 Xtandi Biologics, LLC McKesson Specialty Care 401 Mason Road, La Vergne, TN 37086 Lexiscan & Xtandi Distribution Corporation MarketLab (f/k/a Medi- 6850 SouthBelt Drive, Caledonia, MI 49316 Lexiscan Nuclear, LLC) Medline Industries, Inc. One Medline Place, Mundelein, IL 60060 Lexiscan Metro Medical Supply, Inc. 200 Cumberland Bend, Nashville, TN Xtandi 37228 CuraScript SD 255 Technology Park, Lake Mary, FL 32746 Lexiscan & Xtandi PSS World Medical, Inc. 4345 Southpoint Blvd., Jacksonville, FL Lexiscan Name of ADR Address Products Covered 32216 Smith Medical Partners, LLC 960 Lively Blvd., Wood Dale, IL 60191 Xtandi Other Perrigo Pharmaceuticals 515 Eastern Avenue, Allegan, MI 49010 Tacrolimus Ointment: Company -0.03%, NDC 45802-390-00, 01, 02 -0.1%, NDC 45802-700-00, 01, 02

OSI Pharmaceuticals, LLC Authorized Distributors of Record Name of ADR Address Products Covered U.S. Wholesalers/Distributors AmerisourceBergen Corporation 1200 E. Fifth Avenue, Columbus, OH 43219 Tarceva® Cardinal Health 2600 Titan Row, Orlando, FL 32809 Tarceva® 41093 County Center Drive, Temecula, CA FFF Enterprises, Inc. Tarceva® 92951 H.D. Smith Wholesale Drug 1101 West Vickery Blvd., Fort Worth, TX 76104 Tarceva® Company, Inc. Komtur Pharmaceuticals, Inc. 202 Tower Drive, Edgewater, NJ 07020 Tarceva® McKesson 520 E North Avenue, Carol Stream, IL 60188 Tarceva® Morris & Dickson 2619 State Highway 124, Winnie, TX 77665 Tarceva® Priority Healthcare Distribution, 995 South McCarran Blvd., Sparks, NV 89431 Tarceva® Inc. Non-U.S. Wholesalers/Distributors Carr. #1, Km. 21.1,Sector La Muda, Guaynabo, Cesar Castillo, Inc. Tarceva® PR 00971

* Astellas Pharma US, Inc.’s product line consists of the following products: Adenocard®, AmBisome®, Astagraf XL®, Lexiscan®, Mycamine®, Myrbetriq®, Prograf®, VESIcare®, Cresemba®, and Xtandi®.

3 Updated 10/01/2016