Systematic Reviews & Meta-Analyses of Diagnostic Test Accuracy

Respiratory Epidemiology and Clinical Research Unit (RECRU) Montreal Chest Institute, Montreal

& Cochrane Infectious Diseases Group (CIDG)

SYSTEMATIC REVIEWS & META-ANALYSES OF DIAGNOSTIC TEST ACCURACY

Dates: May 25 & 26, 2009 Venue: Meakins-Christie Seminar Room, Meakins-Christie Laboratories, 3626, St Urbain St, Montreal

Co-instructors: Dr. Mariska M Leeflang, PhD Dept. of Clinical Epidemiology & Biostatistics, Academic Medical Center, Amsterdam Joint Coordinator, Cochrane Diagnostic Test Accuracy Working Group (DTAWG)

Dr. Madhukar Pai, MD, PhD Dept. of Epidemiology & Biostatistics, McGill University, Montreal Editor, Cochrane Infectious Diseases Group

Monday May 25, 2009

8.00 Registration Ms. Danielle Bastien/Esther Tomkee 8.15 Welcome Dr. Jean Bourbeau, Director, RECRU 8.20 Introductions Dr Pai 8.30 Diagnostic test accuracy: a quick review Dr. Pai 10.30 COFFEE BREAK 10.45 Overview of diagnostic accuracy systematic reviews Dr. Leeflang - Why systematic reviews? - Outline of a review; basic steps 11.15 Formulating a review question and inclusion criteria Dr. Leeflang - PICOs - Objectives of a DTA review - Comparative questions - Which study designs to include? - Participants, tests, etc. 12.00 Identification of DTA studies Dr. Leeflang - Search terms

1 - Databases - Tips and tricks for searching 12.30 – 13.30 LUNCH

13.30 Quality Assessment Dr. Leeflang - Introduction to methodological quality - Assignment 15.00 Example of a diagnostic meta-analysis Dr. Leeflang - Galactomannan detection for invasive aspergillosis 15.45 COFFEE AND CLOSE OF SESSION

Tuesday May 26, 2009

8.30 Introduction to diagnostic meta-analysis Dr. Leeflang - Principles of meta-analysis - sROC curve - Heterogeneity 9.30 Introduction to meta-analytic modelling Dr. Leeflang - Why not pool sens and spec separately? - Moses-Littenberg - Bivariate model - Hierarchical sROC model - When a curve and when an ellipse? 10.30 COFFEE BREAK 10.45 Other issues in diagnostic meta-analysis Dr. Leeflang - More about heterogeneity - More about comparative analyses - More about hypothesis testing - More about publication bias 12.00 Example of a diagnostic meta-analysis Dr Karen Steingart - Serological tests for tuberculosis 12.30 – 13.30 LUNCH 13.30 Demonstration: MetaDiSc Ms Daphne Ling 14.30 Demonstration: SAS / STATA Dr. Leeflang 15.30 COFFEE BREAK

2 15.45 Interpretation of the results Dr. Leeflang (includes assignment) 17.00 Summary, evaluation and wrap-up Dr. Pai 17.15 CLOSURE