Karen K. Miller, M.D

Curriculum Vitae Part I: General Information

DATE PREPARED: 1/9/2002

Name: Karen Klahr Miller

Office Address: Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital

Email: [email protected] FAX: (617) 726-5072

Place of Birth: Baltimore, MD

Education:

1982 B.A. Yale College 1987 B.S. Columbia University School of Journalism 1992 M.D. Johns Hopkins University School of Medicine

Postdoctoral Training:

Internships and Residencies:

1992-1993 Intern in Medicine, Brigham and Women’s Hospital 1993-1994 Junior Resident in Medicine, Brigham and Women’s Hospital 1994-1995 Senior Resident in Medicine, Brigham and Women’s Hospital

Clinical and Research Fellowships:

1995-1996 Clinical Fellow, Endocrine Unit, Massachusetts General Hospital 1996-1998 Research Fellow, Neuroendocrine Unit, Massachusetts General Hospital

Licensure and Certification:

1995 American Board of Internal Medicine Certificate 1995 Massachusetts License Registration 1998 Endocrinology and Metabolism Certification

Academic Appointments:

1995-1998 Postdoctoral Research Fellow in Medicine, Harvard Medical School 1998-2001 Instructor in Medicine, Harvard Medical School 2001-present Assistant Professor of Medicine, Harvard Medical School Karen K. Miller, M.D.

Hospital or Affiliated Institution Appointments:

1995-1996 Essential Clinical Fellow, Department of Medicine, Massachusetts General Hospital 1996-1998 Research Fellow, Department of Medicine, Massachusetts General Hospital 1998-1999 Clinical Assistant, Department of Medicine, Massachusetts General Hospital 2000- Assistant in Medicine, Department of Medicine, Massachusetts General Hospital

Professional Societies:

1992- American College of Physicians 1995- American Association of Clinical Endocrinologists 1997- The Endocrine Society 1997- Women in Endocrinology 1998- Pituitary Society

Awards and Honors:

1982 Summa Cum Laude, Yale College 1982 Phi Beta Kappa, Yale College 1982 Honors in the Philosophy Major, Yale College 1982 Graduation with Honors, Columbia University School of Journalism 1992 Alpha Omega Alpha, Johns Hopkins University School of Medicine 1997 Recipient, National Research Service Award, National Institutes of Health 1998 Recipient, Clinical Research Scholar Award, National Institutes of Health 1998 Recipient, Janet McArthur Award, Women in Endocrinology 1998 Recipient, Boston Obesity Nutrition Research Center Pilot Research Award 1999 Recipient, Clinical Associate Physician Award, National Institutes of Health 1999-2001 Claflin Distinguished Scholar, Massachusetts General Hospital 2000 Recipient, Travel Award, Women in Endocrinology

Principal Clinical and Hospital Service Responsibilities:

1998- Attending Physician, Neuroendocrine Clinical Center, Massachusetts General Hospital 1999- Ad Hoc Reviewer of GAC, Massachusetts General Hospital 2000- Attending Physician, Endocrinology Consult Service, Massachusetts General Hospital

Major Committee Assignments:

Massachusetts General Hospital

2001-present Research Working Group, Women’s Health Coordinating Council (WHCC)

2 Karen K. Miller, M.D.

Editorial Reviewer:

1998- American Journal of Medicine 1998- Journal of Bone Mineral Research 1998- Journal of Clinical Endocrinology and Metabolism 1998- The Endocrinologist 2001- Journal of the American Medical Association

Report of Teaching

Local contributions:

a. Courses

1997- Lecturer, Endocrinology Lecture, Institute of Health Professions.

2000- Lecturer, Endocrine Postgraduate Course, “Hypopituitarism”

Harvard Medical School

1996-1999 Section Leader, Physical Examination of the Thyroid Gland

b. Invited presentations:

1995 Endocrine Grand Rounds “Supra-sellar Germinomas”

1995 Thyroid/Neuroendocrine Conference “Thyroid Disease and Reproductive Function”

1996 Endocrine Grand Rounds “Lymphocytic Hypophysitis”

1996 Reproductive Endocrine Conference “Hypothalamic Amenorrhea”

1998 Pediatric Endocrine Unit Conference “Bone Density, Body Composition and Leptin in Women with Hypothalamic Amenorrhea”

1998 Endocrine Research Lectures “Nutrition and Body Composition Determinants of Bone Mass in Premenopausal Women”

2000 Pediatric Endocrine Unit Conference “Androgen Deficiency in Women with Hypopituitarism”

2000 Medical Grand Rounds “Hypopituitarism: New Aspects”

2000 Neuroendocrine Clinical Conference “Neuroendocrine Cases”

2000 Anorexia Nervosa Symposium “Female Athlete Triad”

2001 Internship Program, Department of Nutrition “Anorexia Nervosa: Medical Complications”

2001 Housestaff Conference, Department of Medicine “Hypopituitarism”

2001 Symposium, “An Integrated Approach to Eating and Weight Disorders: A Primer” “Anorexia Nervosa, Athleticism and Bone Loss – What Every Primary Care Provider and Coach Should Know”

2001 Medical Grand Rounds “Anorexia Nervosa”

2002 Internship Program, Department of Nutrition “Anorexia Nervosa: Medical Complications”

Brigham and Women’s Hospital

1996 Department of Infectious Diseases Conference and Journal Club “The AIDS Wasting Syndrome in Women”

2001 Women’s Health Lecture Series “Anorexia Nervosa: Metabolic Complications”

Regional, national or international contributions

1998 Oral presentation of research findings Endocrine Society “Hypoleptinemia in Women with Hypothalamic Amenorrhea”

1998 Oral presentation of research findings Endocrine Society “Increased Severity of Osteopenia in Women with Anorexia Nervosa Compared to Hypothalamic Amenorrhea: The Importance of Undernutrition as an Etiologic Factor in Premenopausal Bone Loss”

2000 Oral presentation of research findings Endocrine Society “Androgen Deficiency in Women with Hypopituitarism”

2001 Speaker, Advanced Graduate Seminar on Nutrition and Osteoporosis University of Maine, Orono, ME “Anorexia Nervosa: Metabolic Effects”

2001 Speaker, Psychiatry Grand Rounds Acadia Hospital, Bangor, ME “Anorexia Nervosa”

2001 Speaker, Grand Rounds Emerson Hospital, Concord, MA “Bone Loss in Women of Reproductive Age”

2002 Pediatric Grand Rounds Lowell General Hospital, Lowell, MA “Eating Disorders and Skeletal Health: Some Pediatric Insights”

Educational Program Materials:

1998 Central Hypothyroidism due to Pituitary/Hypothalamic Dysfunction, Neuroendocrine Clinical Center Newsletter, Winter 1998, Volume 4, Issue 3

2000 Androgen Deficiency in Women with Hypopituitarism, Neuroendocrine Clinical Center Newsletter, Fall/Winter 2000, Volume 6, Issue 2

Professional National Leadership Roles Related to Teaching:

2001- Medical Advisory Board, Pituitary Disorder Education and Support Group

Bibliography

Original Articles

1. Miller KK, Verma A, Snyder SH, Ross CA. Localization of an endoplasmic reticulum calcium ATPase mRNA in rat brain by in situ hybridization. Neuroscience 1991;43:1-9.

2. Grinspoon S, Corcoran C, Miller K, Biller B, Askari H, Wang E, Hubbard J, Anderson E, Basgoz N, Heller H, Klibanski A. Body composition and endocrine function in women with AIDS wasting. J Clin Endocrinol Metab. 1997;82:1332-1337.

3. Miller, KK, Parulekar, MS, Schoenfeld, E, Anderson E, Hubbard, J, Klibanski A, Grinspoon S. Decreased leptin levels in normal weight women with hypothalamic amenorrhea: The effects of body composition and nutritional intake. J Clin Endocrinol Metab. 1998;83(7):2309-2312.

4. Miller KK, Corcoran C, Armstrong, C, Caramelli, K, Anderson EJ, Cotton D, Basgoz N, Hischhorn L, Tuomala R, Schoenfeld D, Doherty C, Mazer N, Grinspoon S. Transdermal testosterone administration in women with AIDS wasting: A pilot study. J Clin Endocrinol Metab. 1998;83(8):2717-2725.

5. Miller KK, Daly PA, Sentochnik D, Doweiko J, Samore M, Basgoz NO, Grinspoon SK. Pseudo-Cushing’s syndrome in HIV-infected patients. Clin Infect Dis. 1998;27:68-72.

6. Grinspoon S, Corcoran C, Miller K, Wang E, Hubbard J, Schoenfeld D, Anderson E, Basgoz N, Klibanski A. Determinants of increased energy expenditure in HIV-infected women. Am J Clin Nutr. 1998; 68:720-725.

7. Grinspoon S, Miller K, Coyle C, Krempin J, Armstrong C, Pitts S, Herzog D, Klibanski A. Severity of osteopenia in estrogen-deficient women with anorexia nervosa and hypothalamic amenorrhea. J Endocrinol Metab. 1999;84(6):2049-2055.

8. Hadigan C, Miller K, Corcoran C, Anderson E, Basgoz N, Grinspoon S. Fasting hyperinsulinemia and changes in regional body composition in human immunodeficiency virus-infected women. J Clin Endocrinol Metab. 1999;84(6):1932-1937.

9. Miller KK, Grinspoon S, Klibanski A. Cardiovascular risk markers in hypothalamic amenorrhea. Clin Endo. 2000; 53:359-66.

10. Hadigan C, Anderson E, Miller K, Hubbard J, Herzog D, Klibanski A, Grinspoon S. Assessment of macronutrient and micronutrient intake in women with anorexia nervosa. International Journal of Eating Disorders. 2000; 28(3):284-92.

11. Grinspoon S, Thomas E, Pitts S, Gross E, Mickley D, Miller K, Herzog D, Klibanski A. Prevalence and predictive factors for regional osteopenia in women with anorexia nervosa. Ann Int Med. 2000; 133:790-4.

12. Miller KK, Sesmilo G, Schiller A, Schoenfeld D, Burton S, Klibanski A. Androgen deficiency in women with hypopituitarism. J Clin Endocrinol Metab. 2001; 86:561-7.

13. Sesmilo G, Miller KK, Hayden D, Klibanski A. Inflammatory cardiovascular risk markers in women with hypopituitarism. J Clin Endocrinol Metab. 2001; 86:5774-81.

14. Miller KK, Daniels GH. Association between lithium use and thyrotoxicosis caused by silent thyroiditis. Clin Endo. 2001; 55:501-8.

15. Grinspoon S, Thomas L, Miller K, Pitts S, Herzog D, Klibanski A. Changes in regional fat redistribution and the effects of estrogen during spontaneous weight gain in women with anorexia nervosa. Am J Clin Nutr. 2001. (In press)

Reviews

1. Miller K, Klibanski A. Amenorrhea and osteoporosis. In Kleerekoper M, Siris E, McClung M, editors. The bone and mineral manual: a practical guide. San Diego, CA: Academic Press. 1999.

2. Miller KK, Klibanski A. Amenorrheic bone loss. J Clin Endocrinol Metab. 1999; 84(6).

3. Miller KK. Androgen deficiency in women: A commentary. J Clin Endocrinol Metab. 2001; 86:2395-401.

Abstracts

1. Grinspoon S, Miller K, Coyle C, Krempin J, Herzog D, Klibanski A. Increased severity of osteopenia in women with anorexia nervosa compared to hypothalamic amenorrhea . The Endocrine Society 80th Annual Meeting, 1998.

2. Miller K, Corcoran C, Caramelli K, Daugherty C, Mazer N, Grinspoon S. Transdermal testosterone administration in women with AIDS wasting: A pilot study. The Endocrine Society 80th Annual Meeting, 1998.

3. Miller K, Parulekar M, Schoenfeld E, Anderson E, Hubbard J, Klibanski A, Grinspoon S. Hypoleptinemia in women with hypothalamic amenorrhea. The Endocrine Society 80th Annual Meeting, 1998.

4. Grinspoon S, Corcoran C, Miller K, Wang E, Hubbard J, Schoenfeld D, Anderson E, Basgoz N, Klibanski A. Determinants of increased energy expenditure in HIV-infected women . Twelfth World AIDS Conference, 1998.

5. Miller KK, Grinspoon S, Klibanski A. Hypothalamic amenorrhea as an age-independent model of the effects of estrogen-deficiency of cardiac risk factors. The Endocrine Society 81st Annual Meeting, 1999.

6. Miller KK, Sesmilo G, Schiller A, Burton S, Klibanski A. Androgen Deficiency in Women with Hypopituitarism. The Endocrine Society 82nd Annual Meeting, 2000.

7. Soyka LA, Misra M, Miller K, Grinspoon S, Klibanski A. Abnormal Bone Mineral Accrual in Adolescent Girls with Anorexia Nervosa. The Endocrine Society 83rd Annual Meeting, 2001.

8. Miller KK, Klibanski A, Grinspoon SK. Androgen Deficiency in Women with Anorexia Nervosa. The Endocrine Society 83rd Annual Meeting, 2001.

9. Miller KK, Biller BMK, Arena E, Klibanski A. Association Between Androgens and Bone Density in Women with Hypopituitarism. The Endocrine Society 83rd Annual Meeting, 2001.

10. Grinspoon S, Thomas E, Miller K, Bodio K, Mulcahey M, Herzog D, Clemmons D, Klibanski A. Effects of rhIGF-I and Estrogen Administration on IGF-I, IGFBP-2 and IGFBP-3 in Anorexia Nervosa. The Endocrine Society 83rd Annual Meeting, 2001.

11. Wolsko LP, Miller KK, Klibanski A. The natural history of hyperprolactinemia at menopause. The Endocrine Society 84th Annual Meeting, 2002.

12. Misra M, Miller KK, Herzog DB, Bjornson JL, Levitsky LL, Klibanski A. Growth hormone resistance in adolescent girls with anorexia nervosa. The Endocrine Society 84th Annual Meeting, 2002.

13. Miller KK, Thomas ER, Grinspoon SK, Herzog D, Keene KK, Lee H, Klibanski A. Effects of risedronate and IGF-I administration on bone metabolism in women with anorexia nervosa. The Endocrine Society 84th Annual Meeting, 2002.

14. Miller KK, Lee H, Hier J, Sesmilo G, Schoenfeld D, Klibanski A. Measurement of free testosterone in androgen deficient and normal women: Comparison of methods. The Endocrine Society 84th Annual Meeting, 2002.