Experimental Sciences and Technologies

Un iv e r s i t a t de le s UIB Il l e s Ba l e a r s

Doctoral qualification (RD 56/2005 syllabus)

Experimental Sciences and Technologies: NUTRIGENOMICS AND PERSONALISED NUTRITION

SUBJECT DESCRIPTION

Details Subject Name of subject: Nutrigenomics and Personalised Nutrition Timetable: Spring semester Teaching staff Subject leaders Name Research group Tel. Office E-mail

Dr Biochemistry, Molecular Biology, 971173454 Ed.. Mateu -{}-cati.pi Catalina Picó Segura Nutrition and Biotechnology – Orfila, Q. 10 [email protected] Nutrigenomics

Dr Biochemistry, Molecular Biology, 971172734 Ed.. Mateu -{}-luisab M. Luisa Bonet Piña Nutrition and Biotechnology – Orfila, Q. 32 onet@uib. Nutrigenomics es

Number of ECTS credits: 5 Type: Obligatory

Aims

Be aware of basic concepts in personalised nutrition, and in particular interaction between genes and nutrients, and importance in the prevention of and susceptibility to illnesses.

Content

- Introduction. Concept of functional genomics, systems biology, nutrigenomics, nutrigenetics, personalised nutrition. - Diet and gene expression: nutrients as regulators of activity and transcription factors. Nutrients as epigenetic exchange agents. - Diet in early life and metabolic programming. - Diet as a possible risk or preventive factor in illnesses. Gene polymorphisms and responses to diet. Examples related to cardiovascular disease, cancer, osteoporosis. Risk/benefit biomarkers.

1 - Personalised diet intervention: factors to take into account and emblematic examples.

List of skills: - Ability to incorporate scientific progress in own professional field (G3). - Ability to form hypotheses and design studies for their verification (G6). - Skills to analyse data and extract conclusions from results of research (G7). - Ability to work interdisciplinarily (G8). - Respect for ethics and intellectual integrity (G9). - Literature search skills for research and work in the discipline (G11). - Ability to analyse critically relevant bibliography (G12). - Ability to articulate knowledge in oral and written presentations (G13). - Advanced comprehension of the global context in which area of speciality takes place (G14). - Ability to develop work in English (lingua franca of the discipline) (G15). - Understanding that advanced knowledge provides leadership abilities in the field (G17). - Understand the value of knowledge for the community (G18). - Ability to analyse the risk/benefit balance of nutrients and other food components (G20). - Be aware of molecular basics of interactions between nutrients and genomes and their expression (E1). - Be aware of the relationship between nutrition and state of health (E2). - Be aware of the relationship between diet and illnesses (E3). - Apply knowledge from the discipline to improve health (E4). - Be fully aware of the fields of nutrigenomics and personalised nutrition and its repercussion in society (E5). - Be aware of and be able to apply the concept of systems biology (E6). - Be aware of functional and bioactive components of foods (E7). - Be able to design correctly experimental studies and apply them to the fields of nutrigenomics and molecular nutrition (E11). - Be aware of progress in the fields of nutrigenomics, personalised nutrition and molecular nutrition and acquire necessary skills to update this knowledge constantly (E15). - Skills to develop successfully in a professional environment related to nutrigenomics, personalised nutrition and functional nutrition (E17). - Be aware of the variety of fields of knowledge which form part of the areas of nutrigenomics and personalised nutrition (E23).

Methodology

Course type: blended learning, with 15% of time in the classroom. Learning and teaching activities: Activities carried out by tutor with students: - Classes - Tutorials - Seminars for student presentation and discussion

2 Activities to be carried out by students independently: - Short tests, exercises and case studies. - Recommended reading - Literature searches List of methodologies (and percentages of contact time): Theory: classes (45%) - Seminars: coursework, exercises and case studies (40%) - Complementary activities (attending conferences and events) (5%). Tutorials (10%) Learning resources: - PowerPoint presentation in lectures and seminars. - Use of Moodle environment to transmit content and material and as an interactive communication tool. - Bibliographic material (books, scientific articles, databases, etc.). - Computer rooms (Internet searches and general bibliographical databases, principally PubMed).

Assessment criteria and instruments

Two options: 2) Continuous assessment: - Tests (40%) - Participation in seminars and complementary activities (20%) - Presentation in seminar and in writing of coursework in the field of nutrigenomics and other work (40%)

2)- Final exams (with multiple choice and short question sections) (80%). - Written coursework in the field of nutrigenomics (20%).

Bibliography, resources and appendices

- Kaput & Rodriguez. Nutritional genomics: the next frontier in the postgenomic era. Physiol Genomics 2004;16: 166-177. - Corthesy-Theulaz et al. Nutrigenomics: The impact of biomics technology on nutrition research. Ann Nutr Metab 2005; 49: 355-365. - Pegorier, Le May & Girard. Control of gene expression by fatty acids. J Nutr 2002; 134: 2444S-2449S. - Bonet, Oliver & Palou. Nutrientes funcionales en la regulación del peso corporal. Rev Esp Obes 2004; 2: 152-172. - Oommen et al. Roles for nutrients in epigenetic events. Journal of Nutritional Biochemistry 2005; 16: 74-77. - Dolinoy, Weidman & Jirtle. Epigenetic gene regulation: Linking early developmental environment to adult disease. Reproductive Toxicology 2007; 23: 297-307. - Palou et al. Nutrigenómica y obesidad. Rev Med Univ Navarra 2004; 48: 79-91.

3 - Hesketh et al. Nutrient–gene interactions in benefit–risk analysis . British J Nutr 2006; 95: 1232-1236. - Nowell et al. Gene-Nutrient Interactions in Cancer Etiology . Nutrition Reviews 2004; 62: 427-438. - Corella & Ordovas. Single nucleotide polymorphisms that influence lipid metabolism: interaction with dietary factors. Annu Rev Nutr 2005; 25: 341-390 - Chadwick R. Nutrigenomics, individualism and public health. Proceedings of the Nutrition Society 2004; 63: 161-166. - Kussmann, Raymond & Atfolter. OMICS-driven biomarker discovery in nutrition and health. J Biotechnology 2006; 124: 758-787 - Van Steensel. Mapping of genetic and epigenetic regulatory networks using microarrays. Nature Genetics 2005; 37: S18-S24.