Hypersensitivity Reaction and Acute Immune-Mediated Thrombocytopenia from Oxaliplatin

Table 2. Other oxaliplatin-related acute thrombocytopenia reports Author Infusion Age/gender Onset of Hypersensitivit Nadir of Antibodies Treatment Outcome/ number of thrombocytop- y reaction from platelet subsequent oxaliplatin enia and/or oxaliplatin count treatment bleeding after (/µL) oxaliplatin Acute thrombocytopenia Dold et 17, 19 (no 51/F 24 h (17th); 4 h No (17th); yes 7,000 Not done Transfusion Recovery al. [15] event on 18) (19th) (19th) (17th); 2,000 (19th) Beg et al. 5 (2nd 74/F During infusion No 6,000 Platelet IgG Transfusion Recovery/ [16] course) and IgM cetuximab antibodies and irinotecan Beg et al. 2 (2nd 83/F 1 h after No, but altered 41,000 Not done Transfusion Recovery/ [16] course) starting mental status, bevacizumab infusion nausea and , 5-FU, and diarrhea during LV infusion Acute thrombocytopenia with hemolysis (Evan’s syndrome) Sorbye et 9 52/M 1 d No, but back 17,000 Positive Transfusion Recovery al. [17] pain during DAT; no infusion and platelet fever after each antibodies oxaliplatin Sorbye et 13 40/F 1 d No, but back 80,000 Positive No Recovery al. [17] pain during DAT; no infusion and platelet fever after each antibodies oxaliplatin Earle et >15 56/M 5 h No, but feeling 6,000 Positive Steroid, Recovery al. [18] unwell DAT transfusion

1 Table 2. Other oxaliplatin-related acute thrombocytopenia reports (continued) Acute thrombocytopenia with hemolysis (Evan’s syndrome) (continued) Koutras 14 60/M 1 h Yes with fever, 6,000 Positive Transfusion Recovery et al. [19] chills, DAT and steroid vomiting, abdominal and back pain. Buti et al. 11 64/M Several hours Yes with chills 11,000 Positive Plasmapheresis Recovery [20] and back pain DAT; no and steroid platelet antibodies Cobo et 3 (2nd 59/F 24 h No, but back 7,000 Positive Transfusion Recovery al. course) pain during DAT and steroid [21] infusion Santodir- 15 44/F 1 h into Yes with chills, 10,000 Positive Transfusion Recovery occo et infusion abdominal pain DAT; no and steroid al. [22] and nausea 1 h platelet into infusion antibodies Shao et 24, 64/M 1 d No, but noted 4,000 Not done Transfusion Death due to al. [23] during prior intracranial infusion; back hemorrhage pain during infusion Acute thrombocytopenia with hemolytic-uremic syndrome Dahabreh 4 on 52/M Immediately No 50,000 Negative Steroid, fresh Recovery et al. [24] adjuvant with gross DAT and frozen plasma, treatment hematuria IAT hydration and diuretics Phan et 5 65/M Gross No, but back 24,000 Negative Transfusion Recovery/ al. [25] hematuria pain during DAT; and irinotecan, 5- shortly after infusion positive hemodialysis FU and LV infusion platelet antibodies M: male; F: female; DAT: direct antiglobulin test; IAT: indirect antiglobulin test; 5-FU: 5-fluorouracil; LV: leucovorin