Agenda for Annual Review Meeting 2009

AGENDA FOR ANNUAL REVIEW MEETING 2009 UNIVERSITY OF NAIROBI STD/AIDS COLLABORATIVE GROUP MAYFAIR COURT HOLIDAY INN, NAIROBI

Monday, January 26, 2009

8:15 Registration

9:15 – 9:30 OPENING CEREMONIES Chair: Omu Anzala

Opening remarks – Prof. I. Kibwage – Principal, College of Health Sciences, Univ. Nairobi Official opening – Prof. G. Magoha – Vice-Chancellor, Univ. Nairobi

Session I: Special Presentation – New insights into the Epidemiology of HIV in Kenya Co-Chairs: Benson Estambale Joanne Embree

9:30 – 9:50 THE AIDS SITUATION IN KENYA - HIGHLIGHTS - Prof. Alloys Orago (NACC / NASCOP / KEMRI / CDC)

9:50 – 10:05 THE KENYA MODES OF TRANSMISSION (MOT) STUDY - Sobbie Mulindi (NACC / World Bank / UNAIDS)

10:05 – 10:20 USING THE KAIS, MOT AND OTHER HIV RESEARCH TO INFORM THE KENYA NATIONAL AIDS STRATEGIC PLAN (KNASP) STRATEGIC REVIEW - John Kamigwi (NACC)

10:20 – 10:30 - DISCUSSION

10:30- 11:00 Coffee/tea

Session II: Epidemiology, Transmission, Risk Factors I Co-Chairs: Omu Anzala Stephen Moses

11:00 – 11:15 Has HIV prevalence really risen in Kenya? (Alan Ferguson – Constella Futures)

11:15 – 11:30 Cross-sectional survey of HIV, STIs, and sexual behaviour among FSWs in Kisumu (Lilian Langat – KEMRI / Inst of Tropical Medicine / CDC)

11:30 – 11:45 Prevalence of multi-substance abuse and associated risky behaviour among female sex workers in Coast Province: findings from a behavioural study (Saade Abdallah – Univ. Ghent / ICRH / FHI) 11:45 – 12:00 Predictors of pregnancy among HIV-discordant couples in two Kenyan clinical trial cohorts (Kenneth Ngure – Univ.Washington / Univ. Nairobi) 12:00 – 12:15 Association of attitudes and beliefs towards antiretroviral therapy with HIV- seroprevalence in the general population in Kisumu (Craig Cohen – UCSF / KEMRI / Univ. Nairobi)

12:15 -12:30 Estimating the size of the female sex worker population in Kisumu (Frederick Odongo – KEMRI / Institute of Tropical Medicine)

12:30 – 12:45 Beliefs about AIDS prevention in rural Ugandan youth: survey interview results (Paul Ritvo – Univ. Toronto / Makerere Univ.)

12:45 – 1:00 Tenofovir and Emtricitabine/tenofovir pre-exposure prophylaxis to prevent HIV-1 acquisition within HIV-1 discordant couples (Nelly Mugo – Univ. Washington / Univ. Nairobi)

1:00 – 2:00 Lunch

S ession III: Treatment and Care Co-Chairs: Kishor Mandaliya Craig Cohen

2:00 – 2:15 PEPFAR in Kenya in 2008 – update (Warren Buckingham - U.S. Embassy, Kenya Interagency PEPFAR Coordinator)

2:15 – 2:30 Comparing the modified DOTS approach with standard HAART in a Mombasa cohort of HIV-infected persons with health-related quality of life as the primary outcome (Saade Abdallah – Univ. Ghent / ICRH / PopCouncil / Coast Provincial General Hospital)

2:30 – 2:45 Antiretroviral (ARV) drug-associated toxicity among HIV-infected pregnant women: findings from the Kisumu Breast Feeding Study (KIBS) (Nicolas Polle – KEMRI / CDC / Kenya MOH)

2:45 – 2:55 ART programme scale-up in Majengo – successes and challenges (Makobu Kimani - Univ. Manitoba / Univ. Nairobi)

2:55 - 3:05 Adherence issues amongst sex workers on ARVs –the Majengo Clinic experience (Charles Wachihi – Univ. Manitoba / Univ. Nairobi)

3:05 – 3:15 Challenges of management of HIV positive patients on ARV with TB co-infection (Jessie Kwantampora - Univ. Manitoba / Univ. Nairobi)

3:15 – 3:25 Should we initiate HAART at higher CD4+ cell counts among sex workers than currently recommended in the Kenyan ART National Guidelines? (Preston Izulla - Univ. Manitoba / Univ. Nairobi)

3:25 – 3:35 PEP – A need or a want among sex workers? (Grace Gakunji / Joshua Parmeres – Univ. Manitoba / Univ. Nairobi)

3:35 – 3:45 National Guidelines for a minimum package of HIV prevention, care, and treatment services for sex workers in Kenya –updates (Joshua Kimani – Univ. Manitoba / Univ. Nairobi)

3:45 – 4:00 Coffee / tea 4:00 – 4:15 Programme capacity and treatment outcomes during antiretroviral scale-up at the UW/Coptic Hope Centers for Infectious Diseases (Pamela Kohler – Univ. Washington / Univ. Nairobi / Coptic Hospital)

4:15 – 4:30 Incidence of peripheral neuropathy and stavudine use at the UW/Coptic Hope Center or Infectious Diseases (Julius Njoroge - Univ. Washington / Univ. Nairobi / Coptic Hospital)

4:30 – 4:45 IRIS Presentations of Kaposi’s sarcoma (Allan Ronald – Univ. Manitoba / UCSF)

4:45 – 5:00 The role of a “virtual referral system” – lessons learned from the UoN-MCH Pumwani HAART Clinic (Samson Barasa – Univ. Manitoba / Univ. Nairobi)

5:00 – 5:15 Building trust increases HIV/STI service uptake among female sex workers in Mombasa (Francis Kashonga – Univ. Washington / Univ. Nairobi)

6:00 – 9:00 Reception – Holiday Inn Mayfair Court – supported by BD Diagnostics Ltd.; all conference participants invited to attend

Tuesday, January 27, 2009

Session IV: Resistance and Susceptibility to HIV Infection and Disease I Co-Chairs: Walter Jaoko Kristina Broliden

8:30 – 8:40 Infant CD4 C868T polymorphism and acquisition of HIV-1 among infants with HIV-1 infected women in Kenya (Robert Choi – Univ. Washington / Univ. Nairobi)

8:40 – 8:50 Correlates of HIV-1 specific cellular immune responses in exposed, uninfected partners in HIV-1 discordant couples (Victor Nuvor – Univ. Washington / Univ. Nairobi)

8:50 – 9:00 HIV-1 evolution in gag and env is highly correlated but exhibits different relationships with viral load and the immune response (Anne Piantadosi – Univ. Washington / Univ. Nairobi)

9:00 - 9:15 Genome-wide expression analyses of HIV-exposed uninfected commercial sex workers reveal a general down regulation of HIV dependency factors (Elijah Songok – Univ. Manitoba / KEMRI / Univ. Nairobi)

9:15 – 9:30 Genital innate immune factors and HIV susceptibility (Rupert Kaul – Univ. Toronto / Univ. Nairobi)

9:30 – 9:45 Toll-like receptor mediated immune activation in HIV susceptibility and pathogenesis (Richard Lester – Univ. Manitoba / Univ. Nairobi)

9:45 – 10:00 Genetics of HIV resistance: a genome-wide association study of the Pumwani cohort (Paul McClaren – Univ. Manitoba / Harvard Univ. / Univ. Nairobi)

10:00 – 10:15 Long-term non-progression with HIV infection: lessons from HIV-2 (Sarah Rowland- Jones – Oxford Univ, MRC Gambia) 10:15 – 10:30 Ongoing and planned projects between the Karolinska Institute and the Univ. Nairobi (Taha Hirbod, Kristina Broliden – Karolinska Instit.)

10:30 – 11:00 Coffee/tea

Session V: Family Planning and Reproductive Health Co-Chairs: Dorothy Mbori-Ngacha Marleen Temmerman

11:00 – 11:15 The pressure to abort: the experiences of teen mothers in Asembo, rural Western Kenya (N. Ochiel – KEMRI / Inst of Tropical Medicine)

11:15 – 11:30 Modern contraceptive use barriers and facilitators among adolescents in Asembo, rural Western Kenya (D. Adipo - KEMRI / Inst of Tropical Medicine)

11:30 – 11:45 The Maternity in Migori and AIDS Stigma (MAMAS) Study: methods and preliminary results (Janet Turan – KEMRI / UCSF)

11:45 – 12:00 Challenges of promoting male involvement in family planning in Likoni Division, Coast Province (Irene Jao – Univ. Ghent / ICRH)

12:00 – 12:15 High pregnancy rates in a microbicide preparedness study (Wilkister Bosire – Univ. Ghent / ICRH)

12:15 – 12:30 KAP study on female condom use among sex workers (Jane Njoki - Univ. Manitoba / Univ. Nairobi)

12:30 – 12:45 Characterisation of novel microbicide safety biomarkers in East and South Africa (Kishor Mandaliya – Univ. Ghent / ICRH)

12:45 – 1:00 The VivaGel microbicide Phase I clinical trial (Craig Cohen – UCSF / KEMRI / Univ. Nairobi)

1:00 – 2:00 Lunch

Session VI: Bacterial and Viral STIs Co-Chairs: Elizabeth Bukusi King Holmes

2:00 – 2:15 Non-ulcerative STIs in circumcised and uncircumcised men in Kisumu (Supriya Mehta - Univ. Illinois at Chicago / Univ. Nairobi)

2:15 – 2:30 Syphilis in a cohort of HIV discordant couples in Thika (Kenneth Ngure – Univ. Washington / Univ.Nairobi)

2:30 – 2:45 Impact of bacterial vaginosis on cervical immune cell populations (Rupert Kaul – Univ. Toronto / Univ. Nairobi) 2:45 – 3:00 Characterization of the vaginal microflora and the rationale for vaginal probiotics in the treatment of bacterial vaginosis and the prevention of urogenital infections (Rita Verhelst – Univ. Ghent)

3:00 – 3:15 Prevalence and demographics of HSV-2 infection among HIV-discordant couples in Central Kenya (Elizabeth Irungu – Univ. Washington / Univ. Nairobi)

3:15 – 3:30 Specificity and sensitivity of syndromic diagnosis of STIs among men in Kisumu (Supriya Mehta - Univ. Illinois at Chicago / Univ. Nairobi)

3:30 – 3:45 Coffee / tea

3:45 – 4:00 Comparison of APTIMA Combo 2 with culture and microscopy for the detection of Neisseria gonorrheae (Juma Shafi – Univ. Washington / Univ. Nairobi)

4:00 – 4:15 HIV infection and cervical neoplasia in a Kenyan semi-urban population (Lucy Muchiri - Univ. Ghent / ICRH / Univ. Nairobi / Kenyatta National Hospital)

4:15 – 4:30 HPV type distribution in a case series of cervical cancer and precancer in Nairobi, according to HIV serostatus (Gathari Ndirangu - Univ. Nairobi / Intl Agency for Research on Cancer)

4:30 – 4:45 Increased risk of cervical lesions and high-risk HPV infections among female sex workers in Mombasa (Davy Vander Broeck – Univ. Ghent / ICRH / Kenyatta Univ. / Coast Provincial Hospital / Univ. Antwerp)

4:45 – 5:00 Correlation between colposcopy and biopsy results in a cervical cancer screening programme in an HIV care and treatment centre in Western Kenya (Eleanor Opondo – UCSF / KEMRI)

5:00 – 5:15 Cervical cancer screening and treatment among HIV-positive women: presentation of upcoming randomized trials (Michael Chung – Univ. Washington / Univ. Nairobi)

5:15 – 5:30 Correlates of genital HIV-1 shedding among antiretroviral-naïve women initiating therapy (Ruth Gitau – Univ. Washington / Univ. Nairobi)

Wednesday, January 28, 2009

Session VII: Perinatal transmission and HIV/AIDS in children Co-chairs: Grace John-Stewart Carey Farquhar

8:30 – 8:45 Barriers to the uptake of prevention of mother-to-child transmission of HIV-1 (PMTCT) interventions in Kenya (John Kinuthia – Univ. Washington / Univ. Nairobi)

8:45 – 9:00 Where are women accessing PMTCT? Challenges of providing comprehensive PMTCT Services (Ruth Nduati – Univ. Washington / Univ. Nairobi)

9:00 – 9:15 Infant feeding and HIV: An assessment of practices and challenges in Eastern and Western Provinces (Margaret Waithaka – PATH) 9:15 – 9:30 Evaluation of hemoglobin and platelets toxicity in infants born to antiretroviral naïve HIV-infected women who received Zidovudine/Lamivudine and either Nevirapine or Nelfinavir for prevention of mother-to-child transmission (PMTCT) (Humphrey Musuluma – KEMRI / CDC / FHI)

9:30 – 9:40 Traditional practices that may put breastfeeding infants at increased risk for HIV infection among HIV-exposed infants in the Kisumu Breastfeeding Study (John Okanda – KEMRI / CDC)

9:40 – 9:50 Causes of death among participants (women) in a PMTCT trial, Kisumu (Frank Angira – KEMRI / CDC)

9:50 – 10:00 Causes of death among children followed in a PMTCT trial, Kisumu (R. Lando – KEMRI / CDC)

10:00 – 10:15 Male partner involvement and early postpartum mother-to-child transmission of HIV-1 (Adam Aluisio – Univ. Washington / Univ. Nairobi)

10:15 – 10:30 Adherence to ARV by children followed in Kenyatta National Hospital Comprehensive Care Clinic (Bernadette Ngeno – KNH / Univ. Nairobi)

10:30 – 11:00 Coffee/tea

11:00 – 11:15 Phenotypic characterization of HIV-specific CD8 T cells during acute infant HIV infection (Jennifer Slyker – Oxford Univ / Univ. Washington / Karolinska Inst. / Univ. Nairobi)

11:15 – 11:30 Combined Mother and Child Health Booklet (Mildred Mudany – KEMRI / CDC)

S ession VIII: Interventions I Co-Chairs: James Kiarie Robert Bailey

11:30 – 11:45 Baseline data from the Kenya HAART Cell Phone Adherence Intervention randomized controlled trial (Richard Lester, Sarah Karanja – Univ. Manitoba / Univ. Nairobi)

11:45 – 12:00 Extended follow-up of men in the Kisumu male circumcision trial (Robert Bailey - Univ. Illinois at Chicago / Univ. Nairobi)

12:00 – 12:10 From research to practice: update on the Male Circumcision Consortium (Mores Loolpapit - FHI)

12:10 – 12:20 Assessment of staff and infrastructure for comprehensive male circumcision services in five districts of Nyanza (Emma Llewellyn - Univ. Illinois and Chicago / Univ. Nairobi)

12:20 – 12:30 Responding to human resource capacity development and training needs of male circumcision roll-out in Kenya (George Odingo – EngenderHealth)

12:30 – 12:40 Examining the capacity of private sector health providers in Kenya as resources for scaling-up adult male circumcision activities for HIV prevention (Mwende Mbondo - Univ. Illinois and Chicago / Univ. Nairobi) 12:40 – 1:00 Evaluation of a large-scale HIV prevention programme in Karnataka, South India: from inputs to impact (Stephen Moses – Univ. Manitoba) 1:00 – 2:00 Lunch

S ession IX: Epidemiology, Transmission, Risk Factors II Co-Chairs: Jeckoniah Ndinya-Achola Ruth Nduati

2:00 – 2:15 Concurrent partnerships in young, sexually active men in Kisumu (Nelli Westercamp - Univ. Illinois at Chicago / Univ. Nairobi)

2:15 – 2:30 The Kisumu Research Communities Study: a qualitative study of social relations around collaborative HIV research (Philister Madiega – KEMRI / CDC / London School of Hygiene and Tropical Medicine)

2:30 – 2:40 Exploration of Kenya female sex workers and their male partners: life course harm reduction: preparatory phase (Elizabeth Ngugi – Univ.Washington / Univ. Victoria / Univ. Nairobi)

2:40 – 2:50 Stigma and discrimination among bar and sex workers (Veronica Kamau – Univ. Nairobi / Univ. Washington)

2:50 – 3:00 The sex workers of Kibera: a black tomorrow – traumatic violation (Elizabeth Ngugi Univ. Nairobi / Univ. Washington)

3:00 – 3:15 Adolescent enrollment in an incidence cohort study to prepare for future HIV prevention trials in Kisumu (Tereza Omoro – KEMRI / CDC)

3:15 – 3:30 HIV/AIDS and effects of health-related quality of life (Kelvin Storey – RATN)

3:30 – 3:45 Coffee / tea

3:45 – 4:00 Is audio computer assisted self-interview (ACASI) useful in risk behaviour assessment of female and male sex workers in Mombasa? (Eduard Sanders - KEMRI / Univ. Washington / Univ. Oxford)

4:00 – 4:10 How should we compensate human sample donors in research studies? A doctor’s perspective (Joshua Kimani – Univ. Manitoba / Univ.Nairobi)

4:10 – 4:20 Post study obligations – the unfolding debate (Joshua Kimani / Omu Anzala – Univ. Manitoba / Univ. Nairobi)

4:20 – 4:30 Benefit sharing with developing countries – the GenBenefit Project overview (Joshua Kimani - Univ. Manitoba / Univ. Nairobi)

4:30 – 7:00 Satellite meeting – Proposal writing workshop (Keith Fowke – U.Manitoba)

Thursday, January 29, 2009 Session X: Resistance and Susceptibility to HIV Infection and Disease II Co-chairs: Ephantus Njagi Keith Fowke

8:30 – 8:45 The role of immune quiescence in resisting HIV infection (Keith Fowke – Univ. Manitoba / Univ. Nairobi)

8:45 – 9:00 Trim5a Exon 2 polymorphism is associated with protection from HIV-1 infection in the Pumwani sex worker cohort (Ma Luo – Univ. Manitoba / Univ. Nairobi)

9:00 – 9:10 Elevated Treg frequencies and decreased T cell activation in resistance to HIV infection (Catherine Card - Univ. Manitoba / Univ. Nairobi)

9:10 – 9:20 Ultra-deep pyrosequencing of cpn60 universal target to characterize the vaginal microbiome of commercial sex workers in the Pumwani cohort (John Schellenberg – Univ. Manitoba / Univ. Nairobi / Univ. Saskatchewan)

9:20 – 9:30 Polyfunctionality and epitope specificity of central and effector memory CD8+ T cells in chronic HIV infection (Meika Richmond – Univ. Manitoba / Univ.Nairobi)

9:30 – 9:40 A genome-wide association study identifies a novel candidate gene for protection against HIV-1 infection in highly-exposed yet uninfected Kenyan sex workers (James Sainsbury – Univ. Manitoba / Univ. Nairobi / Karolinska Instit)

9:40 – 9:50 Associations of HLA-DRB with resistance or susceptibility to HIV-1 infection in the Pumwani sex worker cohort (Philip Lacap – Univ. Manitoba / Univ. Nairobi)

9:50 – 10:00 Sequence-based genotyping of killer cell immunoglobulin-like receptors and their associations with HIV-resistance and disease progression (Rae-Anne Hardie – Univ. Manitoba / Univ. Nairobi)

10:00 – 10:10 A G protein signaling gene polymorphism affects HIV disease progression (Jennifer Juno – Univ. Manitoba / Univ. Nairobi)

10:10 – 10:20 Antiproteases and anti-virals are over-expressed in the cervical mucosa of HIV-1 resistant sex workers. Are these protecting against HIV-1 infection? (Adam Burgener – Univ. Manitoba / Univ. Nairobi)

10:20 – 10:30 Polyfunctional HIV-specific CD4 responses in HIV-resistant versus infected sex workers dues to specific HIV-1 epitopes (James Mwanjewe – Univ. Manitoba / Univ. Nairobi)

10:30 – 10:40 Does high plasma activity of endogenous antioxidants protect CD4+ T cells in HIV resistant sex workers? ((James Mwanjewe – Univ. Manitoba / Univ. Nairobi)

10:40 – 11:00 coffee/tea

Session XI: Training and Capacity-Building Co-Chairs: Christina Mwachari Scott McClelland 11:00 – 11:15 Training HIV programme managers for Kenya (James Kiarie - Univ. Nairobi / Univ. Washington)

11:15 – 11:30 Improving the skills of clinical officers: the role of mentorship and education at the UW/Coptic Hope Center for Infectious Diseases (Antony Etyang - Univ. Washington / Univ. Nairobi / Coptic Hospital)

11:30 – 11:45 Regional AIDS Training Network’s response to trends in HIV and AIDS training in Eastern and Southern Africa (Kelvin Storey – RATN)

11:45 – 12:00 The International Centre for Infectious Diseases (ICID) – providing innovative leadership and collaborative solutions to the global fight against infectious disease (Wendy Schettler – ICID

12:00 -12:15 Funding opportunities – European and Developing Countries Clinical Trials Partnership (EDCTP) (Walter Jaoko - Univ Nairobi)

12:15 – 12:30 The Tibotec Global Access Programme in Sub-Saharan Africa (Mary Owor – Tibotec)

12:30 – 1:00 Epidemic and Response to HIV/AIDS in China and Capacity-Building to respond to HIV/AIDS in China (Nancy Yu. Jianxin Zhang, Xiao Ma – Univ. Manitoba / Sichuan Univ)

1:00 – 2:00 lunch

2:00 – 2:20 The science and politics of HIV (Marleen Temmerman – Univ. Ghent)

2:20 – 2:40 title forthcoming (Yiwu He - Bill and Melinda Gates Foundation)

2:40 - 3:00 Zoonotoc disease activities at the Canada National Microbiology Laboratory and the potential for collaborative projects in Kenya (Mike Drebot, Harvey Artsob – Public Health Agency of Canada)

3:00 – 3:15 Microbial Bioinformatics at Canada’s National Microbiology Laboratory (Gary Van Domselaar - Public Health Agency of Canada

3:15 – 3:30 The infectious disease specialty and global health (Allan Ronald – Univ. Manitoba)

3:30 – 3:45 Coffee / tea Session XII: Interventions II Co-Chairs: Elizabeth Ngugi Allen Ronald

3:45 – 4:00 A qualitative study of the influence of antiretroviral therapy on sexual risk behaviour in high-risk women (George Wanje – Univ. Washington / Univ. Nairobi) 4:00 – 4:10 The Nairobi Sex Workers Outreach Programme (SWOP) – a success story? (Gloria Gakii – Univ. Manitoba / Univ. Nairobi) . 4:10 – 4:20 Sex worker mobilization challenges (Cecilia Kariuki, Jane Kamene – Univ. Manitoba / Univ. Nairobi)

4:20 – 4:30 Vulnerable groups – is a sex worker a special client? (Naomi Ireri - Univ. Manitoba / Univ. Nairobi)

4:30 – 4:45 Home-based – Household TB/HIV screening initiative – MCH clinic (Judith Kusimba – Univ. Manitoba / Univ. Nairobi)

4:45 – 5:00 Extending the durability of first-line antiretroviral therapy: a pilot study of directly- administered antiretroviral therapy (DAART) (Linnet Masese – Univ. Washington / Univ. Nairobi)

5:00 – 5:10 Concurrent sexual relationships and the risk of STIs among fisherman (Enos Omondi – UCSF / KEMRI / Univ. Nairobi)

5:10 – 5:20 Travelling and spending a night away from home among fishermen: an opportunity to engage in risky sexual behaviour? (Zachary Kwena - UCSF / KEMRI / Univ. Nairobi)

5:20 – 5:30 Changes in behavioural and STI prevalence among fishermen at two time points (Norton Sang - UCSF / KEMRI / Univ. Nairobi)

Friday, January 30, 2009

Session XIII: Interventions III Co-Chairs: Nelly Mugo Julie Overbaugh

8:30 – 8:45 Towards establishing the laboratory reference ranges for T-lymphocyte subsets in Kenyan adults (Ephantus Njagi – Univ.Nairobi)

8:45 – 9:00 The Il Ngwesi HIV/AIDS Control Project (Katharine Hagerman, Saaya Karmushu – Univ. Toronto / FHI)

9:00 – 9:15 Lessons learned from the implementation and evaluation of vocational skills trainings and microfinances for young people in Asembo and Gem (B. Oyugi – KEMRI / Inst of Tropical Medicine)

9:15 – 9:30 Update on the Phase III randomized placebo-controlled trial of HSV-2 suppression to prevent HIV transmission among HIV-discordant couples (Nelly Mugo – Univ. Washington / Univ. Nairobi)

9:30 – 9:45 Gender-Based Violence and Recovery Centre, Coast Province General Hospital: providing comprehensive care (Jennifer Othigo – Univ.Ghent / ICRH / Coast General Hospital)

9:45 – 10:00 Disseminating results to study participants: experiences from the Kisumu Breastfeeding Study (KiBS) (K. Ondenge – KEMRI / CDC)

10:00 – 10:30 FACES Project: - Laboratory networking to support decentralization of quality HIV services in rural Kenya (Noel Odhiambo – UCSF / KEMRI / Univ. Nairobi) -Maximizing human resources by involving lay health workers in HIV service delivery in Kenya (George Agengo - UCSF / KEMRI / Univ. Nairobi)

10:30 – 11:00 coffee/tea

Session XIV: Vaccine studies Co-Chairs: Rupert Kaul Blake Ball

11:00 – 11:15 An open randomized phase I/II study evaluating safety and immunogenicity of a candidate HIV-1 vaccine, MVA.HIVA, administered to healthy infants born to HIV- infected mothers (Walter Jaoko - Univ. Nairobi / Univ. Washington / MRC Oxford / MRC Gambia)

11:15 – 11:30 Screening test of concept (STOC) trials to accelerate HIV vaccine trials (Helen Thompson - IAVI)

11:30 – 11:45 Pregnancies in clinical trials (Gaudensia Mutua - IAVI)

Session XV: Counselling and Testing Co-Chairs: Kawango Agot Marcel Reyners

11:45 – 12:00 Promotion of couples HIV counseling and addressing barriers to HIV disclosure, and willingness of men to be tested for HIV in Kenya – in-depth interviews and focus group discussions (Nelly Mugo - Mugo – Univ. Washington / Univ. Nairobi)

12:00 – 12:15 Group therapy for HIV and ART adherence works (Gloria Gakii – Univ. Manitoba / Univ. Nairobi)

12:15 – 12:30 Effects of disclosing HIV+ status to significant others – Baba Dogo Clinic (Grace Kamunyo - Univ. Manitoba / Univ. Nairobi)

12:30 -12:45 Prevention with the positive (discordant) couples - (Maureen Akolo - Univ. Manitoba / Univ. Nairobi)

12:45 – 1:00 ART support groups for sex workers – the Majengo Clinic experience (Elizabeth Bwibo - Univ. Manitoba / Univ. Nairobi)

1:00 – 2:00 Lunch S ession XVI: Epidemiology, Transmission, Risk Factors III Co-Chairs: Joshua Kimani Barbara Lohman-Payne

2:00 – 2:15 A sensitive in-house genotypic assay utilizing dried blood spots for HIV-1 drug resistance surveillance and monitoring (Clement Zeh – KEMRI / CDC)

2:15 – 2:30 Preliminary profile of the first HIV drug resistance (HIVDR) monitoring cohort from a public health facility in Mombasa (Millicent Olulo – Univ. Ghent / ICRH / Coast Provincial Hospital / Univ. Amsterdam)

2:30 – 2:45 Prevalence and susceptibility of Cryptococcus neoformans to Fluconazole in HIV patients in Kenya (Rennatus Mdodo – Univ. Alabama / Univ. Nairobi)

2:45 – 3:00 Genetic characterizations of HIV-1 viruses among recent and long-term infections, from anti-retroviral naïve persons in rural Western Kenya (Lillian Nafisa – KEMRI / CDC)

3:00 – 3:15 Factors influencing condom use among male sex workers in Mombasa (M. Syengo – Univ. Ghent / ICRH / Pop Council)

3:15 – 3:30 Knowledge, attitudes and practice on sexuality issues among HIV and RH service providers: preliminary findings of a rapid assessment from Kenya (Carolyn Mackenzie – FHI / Ministry of Medical Services / Ministry of Public Health and Sanitation) .

3:30 – 4:00 Summing up (Benson Estambale, Omu Anzala, Joanne Embree, Marleen Temmerman)

CLOSING CEREMONIES - Closing remarks – Prof. Z. Ngumi, Dean, School of Medicine, Univ. Nairobi (to be confirmed)

4:00 coffee/tea