Tonic Status in Patients with Idiopathic Generalized Epilepsy

EEG-fMRI in PMG Kobayashi et al MS 2004/077008 Legends for tables:

F: female, M: male U: unilateral, B: bilateral PMG: polymycrogyria PPMG: perisylvian PMG, FPMG: frontal PMG, PaOPMG: parieto-occipital PMG Fo: focal, H: hemispheric, W: widespread, L: left, R: right, post: posterior N/A: not applicable GSW: generalized spike-and-wave GSPS: generalized spikes and polyspikes Fr: frontal, T: temporal, C: central, P: parietal, O: occipital Post : posterior

Table (E)T-1: Demographic and clinical data of the nine patients studied.

Patient # Sex, Age PMG Classification Previous Surgery 1 F, 42 BPPMG no 2 F, 22 BPPMG no 3 F, 25 BPPMG no 4 M, 37 UPPMG TP resection 5 F, 35 BPPMG anterior callosotomy 6 M, 42 BPPMG T resection 7 M, 42 BFPMG anterior callosotomy 8 M, 41 UPaOPMG no 9 F, 42 BPaOPMG no EEG-fMRI in PMG Kobayashi et al

Table (E)T-2: Patterns of activation and deactivation.

Spike Patient # PMG distribution Spike Activation Max fMRI activation Deactivation Max fMRI deactivation (study #) type (#) class in the lesion (Max. t, vol., relationship with lesion) in the lesion (Max. t, vol., relationship with lesion)

1 (1) * BPPMG F8T4 (23) Fo No R PO (5.4, 9.8cm3, outside) N/A N/A

1 (2) BPPMG F7T3 (76) Fo Yes R P (4, 2.1cm3, within lesion) N/A N/A

2 (3) BPPMG BSW (204) W Yes L FrT perisylvian (10.8, 304.8cm3, within lesion) No B post cingulate (-9.3, 22.1cm3, outside)

2 (4) BPPMG F8T4T6 (4) Fo Yes L Fr (4.1, 0.9cm3, on the edge) N/A N/A

3 (5) BPPMG F7T3 (21) Fo Yes L TPO (7.9, 49.2cm3, within lesion) N/A N/A

4 (6) UPPMG Fp2F4F8 (8) Fo Yes R P (9, 38.8cm3, within lesion) No R PO (-5.1, 1.2cm3, outside)

5 (7) BPPMG GSW (231) W Yes L TPO (7.7, 4.4cm3, on the edge) Yes B post cingulate (-7.7, 3.9cm3, outside)

5 (8) BPPMG P3T5O1 (110) Fo Yes L Fr (4.1, 1.6cm3, on the edge) Yes L O (-4.1, 0.6cm3, outside)

5 (9) BPPMG F8T4T6O2 (7) H N/A N/A No R Fr (-4.9, 0.6cm3, outside)

5 (10) BPPMG BPTO (266) B Yes L TPO (4.4, 0.8cm3, on the edge) No L T (-4.2, 0.7cm3, outside)

6 (11) BPPMG F4C4P4 (91) Fo Yes R precuneus (4.6, 1cm3, outside) No L O (-4, 1.5cm3, outside)

7 (12) BFPMG F3F7T3 (169) Fo N/A N/A N/A N/A

7 (13) BFPMG BFT (4) B Yes L T (7.1, 4.8cm3, outside) Yes L FrT (-4.9, 1.7cm3, within lesion)

7 (14) BFPMG F7T3 (3) Fo Yes L T (10.1, 7.5cm3, outside) Yes L CP (-8.3, 408.7cm3, on the edge)

8 (15) UPaOPMG F7T3 (6) Fo N/A N/A No R TO (-3.8, 0.9cm3, outside)

8 (16) UPaOPMG Fp2F4F8 (2) Fo N/A N/A N/A N/A

9 (17) BPaOPMG GSPS (241) W Yes R mesial post T (7.8, 25.1cm3, outside) Yes B post cingulate (-12.7, 11.9cm3, outside)

9 (18) BPaOPMG T4T6 (20) Fo N/A N/A No R T (-4.3, 0.75cm3, outside) * Study #1 from patient #1 with BPPMG, consisted of 23 spikes involving electrodes F8 and T4. This study, which was classified as Focal spikes, showed activation, but no involvement of the lesion was observed. The peak of maximum response was located in the R PO region, with a maximum t value of 5.4

16 EEG-fMRI in PMG Kobayashi et al and a volume of 9.8cm3, and therefore, the maximum activation occurred outside the lesion boundaries. There was no deactivation, therefore deactivation involving the lesion and maximum deactivation are labeled N/A.