Proforma for Registration of Subjects for Registration

From, Dr. PRAVEENKUMAR TALIKOTI I MD (Ayu) SCHOLAR, Department of Post Graduate Studies in Rasashastra, Taranath Govt. Ayurvedic Medical College, BELLARY – 583101

To, THE REGISTRAR (EVALUATION), Rajiv Gandhi University of Health Sciences, Karnataka, BANGALORE.

Through

The Principal and H.O.D Post Graduate Studies in Rasashastra, Taranath Govt., Ayurvedic Medical College, BELLARY – 583101.

Respected Sir,

Sub: Submission of completed Proforma for registration of Subject of Dissertation.

I request you to kindly register the below mentioned subject against my name for the submission of dissertation to the Rajiv Gandhi University of Health Sciences, Bangalore for the partial fulfillment of M.D (Ayurveda).

TITLE OF THE DISSERTATION:

“PHARMACEUTICO – ANALYTICAL STUDY OF PRAVALA GARBHA POTTALI”

Here with I am enclosing completed Proforma for registration of subject for dissertation.

Thanking you Sir,

Place : Bellary Yours Faithfully Date :

Dr. PRAVEENKUMAR TALIKOTI RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES, KARNATAKA, BANGALORE

ANNEXURE – II

PROFORMA FOR REGISTRATION OF SUBJECT FOR DISSERTATION

1. Name of the candidate & : Dr. PRAVEENKUMAR TALIKOTI Address I MD (Ayu) Department of Post Graduate Studies in Rasashastra, Taranath, Govt., Ayurvedic Medical College, BELLARY-583101

Dr.PRAVEENKUMAR S/O B.G.TALIKOTI SHANTINAGAR HAKEEM CHOWK BIJAPUR-586104 KARNATAKA STATE

2. Name of the Institution : Taranath Govt. Ayurvedic Medical College, BELLARY-583101

3. Course of Study and Subject: 1stYearM.D(Ayu)Rasashastra

4. Date of Admission to Course: 15th November 2010

5. Title of the Topic :

“PHARMACEUTICO–ANALYTICAL STUDY OF PRAVALAGARBHA POTTALI” 6. BRIEF RESUME OF THE INTENDED WORK

6.1 NEED FOR THE STUDY

Pottali kalpana is an unexplored, innovative sector of Rasashastra, even though it has many advantages like least product wastage minimal drug requirement when compared to other Rasayogas, its manufacturing and applied research is very less in current era.

Research is to explore the unexplored part of the science. Drug research is expected to work in the rare pharmaceutical molecules. In classics there is reference about “ PRAVALA GARBHA POTTALI1” is a classical Pottali Rasayana containing Pravala Bhasma, Muktashukti Bhasma, Kapardika Bhasma, Shankha Bhasma, Godanti Bhasma, Shuddha Parada, Shuddha Gandhaka and Suvarna Tanutantu Khanda. Which is rare unique ,potent,, novel molecule with highly promising therapeutic application. To manufacture the PRAVALAGARBHA POTTALI as per the classics, the present pharmaceutical study is undertaken.

The current trend in the medical research encourages good manufacturing product and good clinical practice, which is based on drug analysis. The main aim of analytical study is to find out working standards for the formulations and safe use of therapeutics.2 Therefore the basic and effective analytical method to assess the Pharmaceutico- Analytical properties of the “PRAVALAGARBHA POTTALI” is the need of the hour. Hence the present study entitled

“ PHARMACEUTICO-ANALYTICAL STUDY OF PRAVALAGARBHA

POTTALI” is under taken. 6.2 REVIEW OF LITERATURE  Extraction of Parada from Hingula3  Shodhana of Gandhaka4  Vishesha Shodhana of Suvarna5  Shodhana6 and Marana7 of Pravala. .  Shodhana8 and Marana9 of Kaparda.  Shodhana10 and Marana11 of Muktashukti  Shodhana12 and Marana13 of Shankha  Shodhana14 and Marana15 of Godanti .  Preparation of Pravala Garbha Pottali.1  The relevant classical texts will be reviewed for the preparation of PravalaGarbha Pottali and its ingredients.

 Previous Works published in Relation of the Subject: No previous works have been carried out.

6.3 OBJECTIVES OF THE STUDY: 1.1. To Carry out Extraction of Parada from Hingula 1.2. To Carry out Shodhana of Gandhaka 1.3. To Carry out Vishesh Shodhana of Suvarna 1.4. To Carry out Shodhana and Marana of Pravala, Muktashukti ,Kaparda,Shankha and Godanti 1.5. To Carry out Preparation of Pravala Garbha Pottali. 1.6. To carry out Analytical study of prepared PravalaGarbha Pottali .

7. MATERIALS AND METHODS 7.1 Source of data: 1. Genuine raw materials will be collected from authentic source. These will be screened for Grahya Lakshanas. 2. Necessary processing of raw materials and preparation of Pravala Garbha Pottali will be done in pharmacy section of P.G.Department of Rasashastra, in Taranath Govt.Ayurvedic Medical College, Bellary. 3. Analytical studies of PravalaGarbha Pottali will be carried out at accreditavaled laboratories. 7.2 METHODS OF COLLECTION OF DATA

1) Literary study:  Data from relevant classical texts will be collected for PravalaGarbha Pottali.

2 Pharmaceutical study:  Extraction Parada from Hingula by subjecting it to Urdhvapatana method3.

 Gandhaka Shodhana will be carried out in Godugdha by subjecting it to Kurma Puta by Bhoodhara Yantra method.4

 Vishesha Shodhana of Svarna will be carried out in Kanchanara Swarasa by Nirvapa method5

 Shodhana of Praval will be carried out by Swedana by Sarjika kshar jala for Three hrs.6

 Marana of Pravala is done by giving Bhavana with Kumari swarasa and subjecting to Three Gajaputa7  Shodhana of Muktashukti by Nimbu Swarasa by Swedana for Three hrs8  Marana of Muktashukti is done by giving Bhavana with Kumari swarasa and subjecting to Gajaputa9.  Shodhana of Kaparda by Kanji by Swedana for Three hrs10.  Marana of Kaparda by subjecting to Gajaputa11.  Shodhana of Shankha by Kanji by Swedana for Three hrs12  Marana of Shankha by subjecting to Two Gajaputa13.  Shodhana of Godanti by Nimbu Swarasa by Swedana for One and half hr14.  Marana of Godanti is done by giving Bhavana with Kumari swarasa and subjecting to Gajaputa.15.  Preparation of Pravala Garbha Pottali .1 Ingredients – Pravala Bhasma,Muktashukti Bhasma,Kaparda Bhasma,Shanka Bhasma- Each 2pala,Godanti Bhasma – 4 Pala , Shuddha Parada- 1 Karsha , Shuddha Gandhaka - 1 tanka and Suvarna Tanutantu Khanda- 6 Rattika . Method of preparation - Suddha Parada and Swarna Patra taken in clean Khalva yantra and made into Dhatu Pisti , then Pisti prakshalana is to be carried out. Shodhita Gandhaka is added to Dhatu Pisti , Mardana will be carried out till Kajjali lakshanas appear. Then Bhasmas are to be added to the Kajjali, and then subjected to Mardana. After the preparation of Kajjali the Bhavana will be given with Kumari Swarasa for Seven times, and Shikhararambha or Poogakara shape will be given, then dried under shade. After this the dried Poogakara Pottali is tied in four layered silk cloth containing Shodhita Gandhaka , then subjected to Gandhaka paka till Pottali siddhi lakshanas appear.

Parameters To Asses Pottali Paka Lakshana:  Colour of Gandhaka should be Aruna/Vyoma varna.

 Silk cloth should be burnt.

 Colour of Pottali should be Shweta Varna.

 Analytical Study:

Physical tests: i) Organoleptic characters. ii) PH Value. iii) Loss on drying at 1100 C. iv) Ash Value. v) Acid insoluble ash. vi) Loss on ignition.

Chemical Tests : i) Qualitative analysis – XRD , XRF , FTIR, NPST. ii) Quantitative analysis - volumetric analysis. iii) Partical Size Analysis.

7.3 Does the study require any investigation or intervention to be conducted on patients or other humans or animals if so, please describe briefly. No

7.4 Has ethical clearance has been obtained from your institution in case of 7.3 Not applicable

8. List of References: 1. Viadya Pandit Hariprapannaji, Rasayogasagara, 1st edition, Varanasi, Chowkhambha Krishnadas Academy Publication, Reprinted 2010, vol-2, 582pp 2. Dr.K.Raghunathan & V N K Ramadas Pharmacopoeial Standards for Ayurvedic Formulations, 1st edition, Delhi published by CCRIM & H, 1976, prologue 3. Shri Sadananda Sharma, Rasa Tarangini,Edited by Pandit Kashinath Shastri, 11th Edition New Delhi, Motilal Banarasidas Publication 1979, 5th Taranga, verses 38- 42, 82pp 4. Acharya Shri Madhava, Ayurveda Prakasha Edited by Shri Gulrajsharma Mishra, Varanasi, Published by Chaukhambha Bharati Academy, reprint 2007, 2nd Chapter, Verse 19 , 260 pp 5. Vaidya Lakshmipathi Shastri, Yogaratnakara, edited by Bhishgratna Brahmashankara Shastri, 6th Edition, Varanasi, Chowkhambha Sanskrit Samsthan, 1997, Purvardhagata Vishaya Suchi Verse-1, 128pp 6. Shri Sadananda Sharma, Rasa Tarangini Edited by Pandit Kashinath Shastri, 11th Edition New Delhi Motilal Banarasidas Publication 1979, 23rd Taranga, verse 132, 627pp 7. Ibid, 23rd Taranga, Verses 134-135, 627pp. 8. Ibid, 12th Taranga, Verse 66, 296pp 9. Anonymous-The Ayurvedic Formulary of India, second revised English edition, Govt. of INDIA Ministry of Health and Family Welfare, Department of Indian Systems of Medicine and Homeopathy , NEW DELHI, Published by The Controller of Publications Civil Lines Delhi, 2003, Part-1 ,18th Section , 238pp 10. Ibid, 18th section,233pp. 11. Ibid, 18th section,233pp. 12. Ibid, 18th section,245pp. 13. Ibid, 18th section 245pp. 14. Ibid, 18thsection 234pp. 15. Ibid, 18thsection 234pp.

9. SIGNATURE OF CANDIDATE:

10. REMARKS OF THE GUIDE:

11. NAME & DESIGNATION (In block Letters)

11.1 Guide: Dr. SUREKHA MEDIKERI M.D.(AYU) PROFESSOR DEPT OF P.G STUDIES RASASHASTRA TARANATH GOVT. AYURVEDIC MEDICAL COLLEGE, BELLARY. 11.2 Signature: 11.5 Head of the Department : Dr. M. S. DODDAMANI M.D.(AYU) PROFESSOR & HOD DEPT OF P.G STUDIES RASASHASTRA TARANATH GOVT. AYURVEDIC MEDICAL COLLEGE, BELLARY.

11.6 Signature :

12 12.1 REMARKS OF THE CHAIRMAN AND PRINCIPAL

12.2 Signature