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CARDIOVASCULAR SCIENCES COLLABORATIVE PROGRAM Faculty of Medicine, University of Toronto

ANNUAL REPORT 2006 – 2007

FitzGerald Bldg., 150 College Street, Room 88, Toronto ON M5S 3E2 Tel: 416/978-0746 Fax: 416/946-5713 E-mail: [email protected] Web site: www.cscp.utoronto.ca 2 CONTENTS

DIRECTOR’S REPORT………………………………………………………………………………….2

MISSION STATEMENT………………………………………………………………………………….4

COLLABORATING DEPARTMENTS…………………………………………………………………..4

COMMITTEES…………………………………………………………………………………………….5 - Executive - Program

COURSES OFFERED…………………………………………………………………………………...5

PROGRAM SPONSORED ACTIVITIES……………………………………………………………….6 - Annual Student Research Day - Student Forum Night - Cardiovascular Summer Initiative - CSI - Human Biology Job Fair

AWARDS…………………………………………………………………………………………………10 - Medtronic Travel Award - Bigelow Book Prize - Lorne Phenix Graduate Award - Ontario Student Opportunity Trust Funds (OSOTF) Award - Ontario Graduate Scholarships in Science and Technology (OGSST)

ADVERTISING MATERIAL…………………………………………………………………………….13

STUDENTS………………………………………………………………………………………………14 - Currently Enrolled - Convocated/Follow-Up - Awards and Honors - Publications

STUDENT ASSOCIATION SPONSORED ACTIVITY………………………………………………19 - Circulation Rounds

ACKNOWLEDGEMENTS………………………………………………………………………………20

FACULTY………………………………………………………………………………………………...21 - Members - Peer Reviewed Funding - Awards and Honors - Publications

3 DIRECTOR’S REPORT

This past year continued the ongoing objectives of the Cardiovascular Sciences Collaborative Program and the possibility of a partnership with the University of Waterloo. A concentrated effort resulted finally with all parties moving forward with the drafting of a Memorandum of Agreement that would clearly result in substantive benefits for both parties. It is hoped that this final step to actually creating this long awaited initiative will occur in the next academic year.

This past year also marked large improvements in our office administrative space capacity to accommodate our ever increasing activities and administrative responsibilities and address a serious environmental issue that arose as a result of a construction project. Due to room conditions that were deemed unhealthy, the CSCP administrator’s office was forced to relocate. The reschuffling of this space now accommodates the other CSCP teaching, administrative and other educational needs by our Subcommittee Chairs and Members as well as other Faculty of Medicine groups who were also feeling the pressure to find reliable space to conduct student meetings etc.

As the CSCP continues to evolve, outside financial support continues to play a key role in our ability to continue providing a rich and fulfilling experience to out students. Thanks go to the HSFO for their support of our Annual Student Research day, while Medtronic, our oldest and most longstanding industry partner, continued to ensure that our annual travel awards were available. This support, together with that of the ongoing university support over the past year and the strong commitment our trainees have to their education, ensured we continued to train a record number of students (MSc:31; PhD:18) in the Program. (see graph below).

55 50 45 40 35 MSc 30 PhD 25 20 Total 15 10 5 0 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006

The JCV series of graduate courses was expanded this year to include the developmental cardiovascular sciences graduate course which had been run through the Department of Physiology. This makes a welcome addition to the available course selections for our trainees across faculties and departments. Also, the other JCV3000 series of courses are becoming oversubscribed, further identifying the need for us to expand our curriculum. Another JCV3000 series course, with a focus on clinical epidemiology of cardiovascular issues, is being discussed and the Curriculum Committee has been hard at work, led by Dr. Viv Rao, to finalize the curriculum for this addition. I would personally like to also extend the appreciation of the CSCP

4 to Dr. Stefan Sebastien Bolz for agreeing to take over one of the JCV courses, replacing Dr. Tsushima, who has moved to York University. Dr. Bolz has done a great job and the course continues to be popular with the graduate students.

The Annual Student Research Day, always a highlight of our year, was this year opened up to Post-doctoral fellows in cardiovascular sciences across campus. This was done in anticipation of the CSCP eventually incorporating a Post-doctoral program as part of its’ training initiatives. This would nicely supplement the existing TACTICS program, which trains a very select group of individuals under mentors across the country. The concept was approved at the annual CSCP Program Committee meeting and Dr. Scott Thomas was charged with flushing out the structure of such a venture. It is anticipated that this will be finalized within the next academic year and be ready for launch after that.

Overall this year has been a busy and satisfying one. Much of our emphasis has been on curriculum renewal, exploring possible joint initiatives with other universities and adding the other allied health Faculties. A new perspective and dimension has now been added to the specialized education experienced by our graduate trainees. A more translational approach is now possible to a broader extent than ever. I welcome this direction as do all the students and anticipate significant curriculum expansion in the upcoming years. The timing is appropriate as the double cohort begins to affect graduate school and our obligations to provide expanded training at this level must be met. The students are also most enthusiastic and I anticipate even further increases in our student enrollment in the upcoming years. To that end our objectives for 2007-2008 change little from this year and we redouble our efforts in all areas as detailed below:

 Establish and launch the joint initiative with the University of Waterloo  Develop innovative curriculum to more appropriately serve the diverse nature of this now multi-Faculty graduate training initiative  Continue developing endowments to provide permanent infrastructure support  Aggressive student recruitment  Graduate training grant applications for both local and external agencies  Further develop CME programs in cardiovascular sciences  Continue developing web-based courses and web casting

As you read through this report, you will see that the Program continues to enrich our trainee’s experiences. Specific details on all activities can be found on our web site at www.cscp.utoronto.ca. I would like to once again recognize the outstanding efforts of Victoria Simpson, our Business Officer, as well as the Executive Committee for their hard work and contributions that have made the Cardiovascular Sciences Collaborative Program the success it is today. And finally, I would like to take this opportunity to thank all our faculty and students for another successful year and to those individuals who have continued to provide both moral and tangible support for this Program.

I continue to be proud to present this Annual Report that summarizes the achievements of the Program’s students and faculty over the past academic year.

Dr. Carin Wittnich, O.Ont. Director, CSCP Professor of Surgery & Physiology Northrop Frye Scholar

5 MISSION STATEMENT

“The Cardiovascular Sciences Collaborative Program, approved by the University and Ontario Council on Graduate Studies in 1992, and listed in the calendar of the School of Graduate Studies, exists to give formal, organized expression to cardiovascular studies and research at the graduate level. It builds on the strengths of all participating academic units, and other agencies, to enhance the visibility of cardiovascular studies and to facilitate collaborative, interdisciplinary training and research.”

The above mission is achieved by advertising and promoting the importance of, and opportunities in, cardiovascular studies, by making known the results of such studies, by recruitment of excellent students, and by coordinating the graduate collaborative program in cooperation with the academic units in which they are registered. Students in this collaborative program must fulfill the requirements of their home units as well as the Program. Upon graduation the notation “Specialization in Cardiovascular Sciences” will appear on the student’s academic transcript and the Program will present the student with a certificate and gift.

COLLABORATING FACULTIES Dentistry Medicine Nursing Pharmacy Physical Education and Health Social Work

COLLABORATING GRADUATE UNITS Biomaterials and Biomedical Engineering Dentistry Exercise Sciences Health Policy, Management & Evaluation Laboratory Medicine and Pathobiology Medical Biophysics Medical Science Nursing Pharmaceutical Sciences Pharmacology Physiology Public Health Sciences Rehabilitation Science

SUPPORTING CLINICAL DEPARTMENTS Anesthesia Medicine Surgery

6 COMMITTEES

Executive The Executive Committee consists of 4 members of the Program Committee representing as wide a range of disciplines as possible and includes the Director. They also act as Chairs of the various subcommittees as noted beside their name. The Executive Committee provides student counseling, screens applicants, provides advice and acts as a Steering Committee.

Dr. C. Wittnich (Fundraising) Dr. M. Rand (Scholarships & Awards) Dr. V. Rao (Membership/Curriculum) Dr. S. Thomas (Student Affairs)

Program The Program Committee consists of a representative from each collaborating department as well as two student representatives. It administers the Program, selects the Director, and generally meets twice per year.

C. Wittnich (Chair) D. Brooks (Rehabilitation Science) S. Wu (Pharmaceutical Sciences) E. Fuller-Thomson (Social Work) D. Mazer (Anesthesia) J. Parker (Pharmacology) S. Heximer (Physiology) M. Ojha (Institute of Biomaterials and Biomedical Engineering) M. Rand (Laboratory Medicine and Pathobiology) V. Rao (Institute of Medical Science) H. Tenenbaum (Dentistry) S. Thomas (Exercise Sciences) J. Tu (Health Policy, Management and Evaluation) J. Watt-Watson (Nursing) G. Wright (Medical Biophysics) President, CSCP Student Association Vice-President, CSCP Student Association

COURSES OFFERED

EXS5508H Cardiovascular Disease and Exercise JCV1060H Developmental Cardiovascular Physiology JCV3060H* Advanced Topics in Cardiovascular Sciences – Molecular Biology & Heart Signal Transduction JCV3061H* Advanced Topics in Cardiovascular Sciences – Hormones JCV3062H* Advanced Topics in Cardiovascular Sciences – Heart Function JCV3063H* Advanced Topics in Cardiovascular Sciences – Vascular JEB1365H Ultrasound: Theory and Applications in Biology and Medicine JTC1331H Biomaterials Science LMP1015H Vascular Pathobiology LMP1504H Cell and Molecular Biology of Cardiovascular Diseases

7 PSL1462H Molecular Aspects of Cardiac Function * Core Courses for PhD Trainees (2 of 4 modules required); JCV denotes joint listing with most of our collaborating departments.

Suggested Courses (Considered valuable but does not fulfill Program requirements) CHL5201 Introducing Biostatistics for Students in Biological Sciences LMP1404S Cellular and Molecular Mechanisms of Disease PSL1052H Fundamentals on Ion Channel Function

PROGRAM SPONSORED ACTIVITIES

Annual Student Research Day The Cardiovascular Sciences Collaborative Program held its 8th Annual Student Research Day on February 21, 2007. All CSCP trainees were in attendance. The morning session began with a retreat where the Student Association highlighted activities from the past year as well as upcoming events. Selected trainees presented their research concepts, designs or results in a series of 10 minute presentations followed by a question period. The presentations were especially polished and professional this year, and covered a broad range of hot topics.

SESSION I: Chair -- Eser Adiguzel Marc Busato (MSc – Exercise Science) “Cardiac Fatigue with Prolonged Strenuous Exercise” Zobia Jawed (MSc – Medical Biophysics) “Studying Protein Networks Common to Endoglin, TGF-beta-receptor 11, and ALK1 in Endothelial Function and Vascular Disorders” Jane MacIver (PhD – Institute of Medical Science) “Understanding the Treatment Preferences of Patients with Advanced Heart Failure” Jessica Prodger (MSc – Institute of Medical Science) “Hypoxia-Mediated Endothelial Progenitor Cell Adhesion” Nazanin Hakimzadeh (MaSc – Biomedical Engineering) “Stem Cell Conooning for Regenerative Medicine”

SESSION 2: Chair -- Nesime Askin Galina Kichigina (MSc – Institute of Medical Science) “Heart Rate Dependent Modulation of Cardiac Myocyte Ca2+ - Handling Protein Expression” Carlo Cifelli (PhD - Physiology) “Sinoatrial Pacemaker Cell Regulation by Regulator of G-Protein Signaling 4” Steve Soric (MSc - Physiology) “Do Sex Hormones Impact on Myocardial Hydrogen Ion and Lactate Accumulation During Ischemia?” Emma O’Donnell (PhD – Exercise Science) “Long Term Estrogen Deficiency Lowers Regional Resting Blood Flow, Heart Rate and Systolic Blood Pressure in Physically Active Premenopausal Women” Cindy Yip (PhD – Biomedical Engineering) “Matrix Stiffness and Mechanoregulation of Cell Phenotypes in Aortic Valve Calcification” Anton Mihic (MSc - Physiology) “Regulation of hERG Channel Gating Kinetics and Expression by the SNARE Protein Syntaxin-1A”

8 Prior to lunch, winners of the Phenix Graduate Award, Danny Quaglietta and the Bigelow Book Prize, Patricia Rose, were announced. We were honoured to have Mrs. Phenix and Kathryn Phenix present to hand out the Phenix award. Certificates and gifts were presented to students who had successfully completed the Cardiovascular Sciences Collaborative Program. After the award ceremony, the meeting broke for lunch.

L-R: Mrs. Phenix, Danny Quaglietta, Dr. Carin Wittnich

L-R: Dr. Carin Wittnich, Pat Rose

The afternoon portion of research day was geared towards showcasing cardiovascular research in the Faculties of Dentistry, Pharmacy and Department of Health Policy, Management and

9 Evaluation. We would like to thank Dr. Howard Tenenbaum (left), Dr. Shirley Wu (centre), and Dr. David Alter (right) for their captivating and enthusiastic presentations.

The Student Research Day met with a resounding success. This day would not have been possible without the efforts of the Planning Committee;

Chair: Dr. Scott Thomas Student Chair: Danny Quaglietta Members: Elissa Tepperman and Albert Tsui

The committee also gratefully acknowledges the Heart and Stroke Foundation of Ontario for their educational grant and the support of Victoria Simpson in making this a very successful day.

Student Forum Night

The 5th Annual CSCP Forum and Dinner was held on December 12th, 2006 at the Chestnut Residence, were the students enjoyed a very delicious holiday dinner. The students were able to gather together in a relaxed atmosphere to discuss their research goals in cardiovascular sciences, their experiences so far at the University of Toronto, and to simply have a nice evening out.

This event was an excellent opportunity for new members of the CSCP to meet one another and for senior participants to catch up with old friends, and develop relationships with the up and comers. Discussion ranged from basic research, laboratory trials and triumphs, to exciting holiday plans. Connections for research collaboration, as well as friendships were developed, and all those in attendance left the event with their bellies and brains full.

10 The dinner was thoroughly enjoyed by all, and many thanks to the organizers of this fantastic evening and for the CSCP Student Association for their sponsorship.

Cardiovascular Summer Initiative – CSI This summer, the CSCPSA organized and ran a very exciting and very successful program called the Cardiovascular Summer Initiative. The series was targeted to undergraduate students involved in cardiovascular summer research, and aimed to give students a more inclusive feel for the field and to provide a broader frame of reference than just lab experience alone.

The first event was an orientation session outlining what the CSCP is and what the goals of our student association are. This was a very successful pilot event and altogether, 25 students signed up for the Cardiovascular Summer Initiative. We had with great student representation especially from IBBME, Lab Medicine & Pathobiology and Physical Education & Health.

The next event was a mini-symposium showcasing the diversity of research that goes on within the CSCP. Six students from within the collaborative program gave presentations: Jessica Jackman (c/o Mitesh Badiwala), Jane MacIver, Geoff De Couto, Steve Soric, Nazanin Hakimzadeh and Lara Gotha. The students really enjoyed the talks and asked meaningful questions about research methods and more general questions about graduate studies.

Even more exciting were the trips that we took with the group. First were the lab tours; two past CSCPSA executive members, Pat Rose and Shathiyah Kulandavelu, were generous enough to offer our group the opportunity to come in for an interactive tour of their lab facilities. At the Retinal Blood Flow lab, Pat gave a short presentation about the various measurements and devices used to diagnose and monitor retinal flow changes and then demonstrated the use of these instruments using our own summer students as volunteers. At the High Resolution Imaging lab, Shathiyah demonstrated the use of imaging instruments such as Doppler flow detector and ultrasound to view the embryos of pregnant mice and visualize developing organs. As well, she let the students find their own pulses using the flow detector, and showed them how they take vascular casts and x-ray images. The best part, remarked one student, was when she used Nair to de-fuzz the mouse!

Our second trip was to the Toronto Rehabilitation Institute. We were provided with a presentation outlining the necessity for and benefits of cardiac rehabilitation and how the program works. In addition, we received a tour of the facility and were even allowed to watch a cardiopulmonary fitness study being performed. Our tour guide discussed the varied backgrounds of the people working in the centre and of particular interest was the fact that many had previously studied exercise science and physical education. Quite a few of our CSI students asked about volunteer opportunities and remarked that they were really excited to learn out about a potential career opportunity for the future.

Finally, we ended the summer program by handing the stage over to our students. Those who were working in labs during the summer gave short presentations of their research to the rest of the group. The presentations were very well done and it was exciting to see budding scientists – the future of the Collaborative Program – in action. At the end of the session, the students thanked the organizers for our hard work and remarked that they are already looking forward to next summer’s program. All were in agreement that they were so glad to have such a unique summer program available to them. Many students also mentioned that they will use the experience they gained from the CSI this summer to obtain volunteer positions and to form decisions about what to do after undergrad.

11 The organizers wish to thank Victoria Simpson for all of her support this summer. We also would like to thank the CSCP students that gave presentations and lab tours. Last, but not least, we would like to thank the students who participated so enthusiastically in this year’s CSI. We look forward to seeing the group as well as some new faces next summer!

Human Biology Undergraduate Student Association Career Fair The CSCP participated in this event which was held on November 15, 2006. The HBSU hosts an annual Life Sciences Graduate School Fair where students have the opportunity to visit different graduate and professional school booths and directly speak with admission representatives and graduate students in various fields of study.

AWARDS

Medtronic Travel Award Two competitions were held (spring and fall) for the Medtronic Travel Award. This award, established in 1995, helps to defray costs of travel for Program students presenting their research work at recognized scientific meetings. Students supported by this award this academic year were:

Fall 2006: Shathiyah Kulandavelu, PhD, Department of Physiology (Supervisor: Dr. L. Adamson) 33rd Annual Fetal & Neonatal Physiological Society Meeting, September 2006. “eNOS augments utero-placental blood flow and uterine artieral enlargement during pregnancy in mice”

Danny Quaglietta, MSc, Department of Physiology (Supervisor: Dr. C. Wittnich) Canadian Cardiovascular Society Annual Meeting, October 2006. “Worse outcome in female children post cardiac surgery – Could differences in cardiac metabolism play a key role?” “Ventricle-specific metabolic response to global ischemia in the newborn heart”

Rohit Sheshgiri, MSc, Institute of Medical Science (Supervisor: Dr. V. Rao) Canadian Cardiovascular Society Annual Meeting, October 2006. “A single-centre retrospective study on human leukocyte antigen-G expression in heart transplant recipients prior to, during, and following episodes of rejection” “The effects of post-transplant stressors on human leukocyte antigen-G expression in the endothelium”

Mila Kisilevsky, MSc, Institute of Medical Science (Supervisor: Dr. C. Hudson) XVII International Congress of Eye Research, Argentina, October 2006. “Retinal vascular reactivity in isoxic and hyperoxic hypercarbia”

Spring 2007: Galina Kichigina, MSc, Institute of Medical Science (Supervisor: Dr. G. Gross) Gordon Research Conference on Cardiac Arrhythmia Mechanisms, California, March 2007. “Heart rate dependent modulation of cardiac myocyte Ca2+ - handling protein expression”

12 Bigelow Book Prize This prize was established in 1995 by the Cardiovascular Sciences Collaborative Program to recognize and honor a pioneer clinician and scientist in the field of cardiovascular sciences. Awardees should exemplify the personal traits of Dr. Bigelow - curiosity, drive, and scientific integrity. The award is given in every year that a qualified student is identified. Qualifications include sustained academic scientific excellence, innovative experimental approaches, original discoveries and good scientific productivity. Some weight is given to work that has recognizable clinical relevance, especially that which promises to improve patient care. The Bigelow Book Prize consists of 2 books written by Dr. W.G. Bigelow entitled “Cold Hearts” and “Mysterious Heparin” and a keeper plaque created to honor Dr. Bigelow. Appropriate candidates are identified and the final decision is made by the Program Committee.

1995 – Dr. John S. Ikonomidis 2002 – Mr. Wm. Jack Wallen 1996 – Ms. Shona M. Torrance 2003 – Dr. Paul W.M. Fedak 1997 – Dr. Vivek Rao 2004 – Dr. Nathalie Lapointe 1998 – Dr. Bryce Cowan 2005 – Dr. Karim Bandali 1999 – Dr. Gideon Cohen 2006 – Mr. Danny Ramzy 2000 – Dr. Michael Borger 2007 – Ms. Patricia Rose 2001 – Dr. Saeid Babaei

L-R: Dr. Carin Wittnich, Patricia Rose

Patricia’s doctoral research has focused on ocular blood flow assessment. Study of retinal autoregulation is important because vascular dysfunction plays a major role in the etiology of such sight-threatening diseases as diabetic retinopathy, age related maculopathy and glaucoma. Patricia helped establish age-related normative data on retinal blood flow regulation in healthy subjects, and correlated retinal vascular changes with novel markers of peripheral vascular disease, including blood levels of cholesterol, C-reactive protein, homocysteine, fibrinogen and lipoprotein (a). The ultimate goal of her research is the development of diagnostic and monitoring procedures that allow the noninvasive assessment of the peripheral vasculature through the eye.

This award is presented at the Annual Student Research Day and unfortunately Pixie Bigelow (daughter of Dr. Bigelow) was unable to participate in this years’ award ceremony and interact with the trainees.

13 Lorne Phenix Graduate Award This award was made possible by a generous donation in the memory of Mr. Lorne Phenix by Mrs. Geraldine Phenix. It is her hope that this award will focus attention on the issue of heart disease – which is still the #1 killer of both men and women in Canada. In addition, women who have heart problems are at least equal if not at greater risk than men and Mrs. Phenix hopes that this award will serve to encourage trainees to pursue this area of research to address this particular problem. It is awarded to a graduate student in the Faculty of Medicine on the basis of research and academic excellence. The award consists of a cash prize and certificate and is presented to the recipient at the Annual Student Research Day. Appropriate candidates are identified and a winner is selected by a subcommittee chaired by Dr. Donna Stewart. This award is presented at the Annual Student Research Day.

2001 – Wm. Jack Wallen 2002 – Wm. Jack Wallen 2003 – Shathiyah Kulandavelu 2004 – Rachel Mitchell 2005 – Nesime Askin 2006 – Danny Quaglietta

L-R: Mrs. Lorne Phenix, Danny Quaglietta, Dr. Carin Wittnich

Danny Quaglietta is an MSc candidate in the Department of Physiology at the University of Toronto. Under the supervision of Dr. Carin Wittnich, Danny’s thesis work is looking at whether gender plays a role in the metabolic response of the newborn heart to global ischemia.

New evidence now suggests that female sex is a risk factor for in-hospital mortality in children undergoing surgical repair for congenital heart disease. Despite females being younger at time of surgery, and undergoing less complex procedures, the overall odds of mortality is 51% greater in female compared to male children. There is evidence in adult literature to suggest that gender affects the heart’s metabolic response to ischemia resulting in worse post-ischemic outcome, however whether these differences occur in the newborn heart that could explain worse outcome in females is currently unknown and was studied.

Danny’s work has shown that the newborn female heart is at a metabolic disadvantage during ischemia, demonstrating both lower energy levels and greater tissue lactic acidosis. These results suggest that newborn females are more susceptible to metabolic damage during ischemia which may offer a potential explanation for increased morbidity and mortality in female children following heart surgery.

14 Danny’s work highlights that female gender is also an important factor that regulates cardiac metabolism in the newborn heart and currently he is investigating possible mechanisms that may be mediating these differences.

Ontario Student Opportunity Trust Funds (OSOTF) Award The OSOTF award refers to a class of awards that have resulted from the Ontario government’s “matching” program. Under the program every dollar of donation received for student assistance has been matched by the government as well as the university on a dollar-for-dollar basis. The Cardiovascular Sciences Collaborative Program participates in this program. There are two major conditions for all OSOTF awards; recipients must be Ontario residents and demonstrate financial need. However, the Program has additional eligibility criteria that must be adhered to, including excellence in science and academic performance. One competition is held per academic year.

The applications are handled centrally through the Office of the Associate Dean, Inter-Faculty and Graduate Affairs. Applications pertaining to the CSCP are sent to us and are then adjudicated by a subcommittee chaired by Dr. Margaret Rand. Committee recommendations are then forwarded to the OSOTF Awards Committee (Faculty of Medicine).

This year’s recipient was Nesime Askin, PhD, Department of Physiology.

Ontario Graduate School Science and Technology (OGSST) The OGSST program is designed to encourage excellence in graduate studies in science and technology. The program is supported through funds provided by the Ministry of Training, Colleges and Universities and by funds raised by the University of Toronto and the Heart & Stroke Foundation of Ontario. To be awarded to graduate students at the University of Toronto who are pursuing cardiovascular/stroke research. Students must have maintained an overall A- average over the last two years of study at the post-secondary level and exhibit research ability/potential, good communication skills and interpersonal/leadership abilities.

Awardees Name Degree Dept. Supervisor Mark David MSc PSL P. Backx Michael Sellan MSc PSL P. Backx Steven Gu PhD PSL S. Heximer Erin Mueller PhD LMP M. Husain Cindy Yip PhD BME C. Simmons Joshua Bell PhD IMS A. Baker Charlene Reynolds PhD IMS W. McIlroy Alexandra Rowland PhD IMS S. Black Jason Wasserman PhD PSL L. Schlicter

ADVERTISING MATERIAL

The CSCP maintains and updates its web site (www.cscp.utoronto.ca). Faculty information is updated whenever we are notified of relevant changes. Collaborating departments are encouraged to provide hypertext links to the CSCP on their web site.

15 STUDENTS

Name Supervisor Degree Department I. Eser Adiguzel M. Bendeck PhD LMP Nesime Askin C. Wittnich PhD PSL Mitesh Badiwala V. Rao PhD IMS Jessica Bronsoiler M. Hough PhD IMS Gian-Marco Busato J. Goodman MSc EXS Kirsteen Burton G. Tomlinson MSc CHL (inactive status) Carlo Cifelli S. Heximer PhD PSL Geoff de Couto P. Liu MSc PSL Katharine Currie J. Goodman MSc EXS Lara Gotha B. Strauss MSc IMS Adam Gwozdz M. Rand MSc IMS Nazanin Hakimzadeh D. Courtman MaSc BME Christy Hamilton M. Locke MSc EXS Judith Hoefer M. Husain MSc IMS Jessica (Jackman) Prodger V. Rao MSc IMS Zobia Jawed M. Letarte MSc MBP Galina Kichigina G. Gross MSc IMS Mila Kisilevsky C. Hudson MSc IMS Shathiyah Kulandavelu L. Adamson PhD PSL Michael Lekas D. Stewart PhD IMS Jane MacIver V. Rao PhD IMS Vaska Micevski D. Stewart PhD IMS (inactive status) Anton Mihic R. Tsushima MSc PSL Forough Mohammadzadeh T. Parker PhD IMS Emma O’Donnell J. Goodman PhD EXS Mark Ormiston D. Courtman PhD BME Maral Ouzounian P. Liu PhD IMS Kumar Perampaladas J. Parker MSc PCL Tenille Ragoonanan G. Hare MSc PSL Danny Ramzy V. Rao MSc IMS Patricia Rose C. Hudson PhD IMS Meghan Sauve D. Drucker MSc IMS Rohit Sheshgiri V. Rao MSc IMS Stjepan Soric C. Wittnich MSc PSL Luka Srejic W. Hutchison MSc PSL Renee Suen D. Stewart PhD IMS Elissa Tepperman V. Rao MSc IMS Albert Tsui G. Hare MSc PSL Michael Ward D. Stewart PhD IMS Cindy Yip C. Simmons PhD BME

16 Convocated Students/Follow-Up

Rami Bishay, MSc, Department of Physiology (Supervisor: Dr. L. West): “High-Frequency Ultrasound Assessment of Cardiac Graft Rejection in Heterotopically Transplanted Mice” (Medical School)

Tetyana Bodnaruk, MSc, Institute of Medical Science (Supervisor: Dr. Alek Hinek): “Neuraminidase-1, a Subunit of the Elastin Receptor, Alters Mitogenic Growth Factor Receptors and Down-Regulates Proliferation of Arterial Smooth Muscle Cells” (Medicine, Pharmaceutical Research)

Erin Butler, MSc, Institute of Medical Science (Supervisor: Dr. Tom Parker): “Critical Dependence on Timing of Cardiac Injection for Retention of Endothelial Progenitor cells and Functional Benefit Post- Myocardial Infarction” (PhD, Germany)

Grace Chan, MSc, Department of Physiology (Supervisor: Dr. Peter Liu): “The Role of Interferon-β in the Attenuation of Cardiac Fibrosis in Coxsackievirus B3-Induced Myocarditis” (Patent agent training)

Danny Quaglietta, MSc, Department of Physiology (Supervisor: Dr. C. Wittnich): “Ventricle- and Sex-Specific Differences in Newborn Heart Metabolism and Response to Global Myocardial Ischemia” (Medicine)

17 John Sun, MSc, Department of Physiology (Supervisor: Dr. Lee Adamson): “The Effects of Insulin-Like Growth Factor Binding Protein-1 on Pre- and Postnatal Cardiac Morphology and Function” (PhD training or start career)

Liana Zucco, MSc, Department of Laboratory Medicine & Pathobiology (Supervisor: Dr. Duncan Stewart): “Genotypic/Phenotypic Analysis of Endothelial Progenitor Cells in Idiopathic Pulmonary Arterial Hypertension and Hereditary Hemorrhagic Telangiectasia” (Medicine, University College of London)

Note: Should discrepancy arise between total number of students enrolled and the number convocated, it can be accounted for students that are incomplete or terminate graduate studies.

Awards and Honors Eser Adiguzel Heart & Stroke/Richard Lewar Centre of Excellence Scholarship

Nesime Askin Mitchell & Venn Graduate Fellowship in Women’s Health OSOTF Student Fund, CSCP 2006 Lorne Phenix Graduate Award, CSCP

Mitesh Badiwala Telomerase Regulation by C-Reactive Protein. PSI, 2005-2006

Gian-Marco Busato 2006 Governor General Silver Medal Nomination Canadian Society of Exercise Physiology Award 2006 The Social Science and Humanities Award 2006 The 2006 Mavis E. Berridge Scholarship

Carlo Cifelli University of Toronto Fellowship

Katharine Currie Glenn H. Carter Fellowship, Exercise Intervention and Disease Prevention Award, UofT

Geoff de Couto University of Toronto Fellowship

Lara Gotha Institute of Medical Science Entry Award, 2006 Institute of Medical Science Open Award, 2006 UofT Life Science Student Research Scholarship, 2006

18 Christy Hamilton University of Toronto Graduate Fellowship Graduate Fellowship for Research in Health & Physical Activity Glenn H. Carter Fellowship, Exercise Intervention & Disease Prevention, UofT

Jessica (Jackman) Prodger Alan Wu Poster Competition, Honorable Mention, Institute of Medical Science, UofT

Galina Kichigina Research Grant in History of Medicine, Fondation Maison des Sciences de l’Homme, France Research Funding in Cardiovascular Science – HSFC/HSC Research Institute

Mila Kisilevsky Vision Science Research Program – OSOTF Student Award, UofT

Shathiyah Kulandavelu Ontario Graduate Scholarship in Science & Technology/Heart & Stroke Fellowship Oral Presentation 1st Place, 6th Annual Perinatal Neonatal Research Day Oral Presentation 1st Place, 33rd Fetal and Neonatal Physiological Society Conference, Cambridge, England RTC Travel Award

Michael Lekas Canadian Cardiovascular Society, Student Presentation Award, Basic Science (runner-up) C. Walton Lillehei Resident Forum Session Finalist, 86th Annual Meeting of the American Association of Thoracic Surgery

Jane MacIver Medical Staff Association, Nursing Excellence Award, 2006

Anton Mihic Poster Competition 2nd Place, HSRLCE Scientific Day, 2007 University of Toronto Open Fellowship, 2006

Emma O’Donnell Terry Kavanagh Fellowship, UofT

Mark Ormiston PGS-D Scholarship, NSERC 2005-2007

Maral Ouzounian Heart & Stroke Foundation Research Fellowship Canadian Institute of Health Research Fellowship Heart Failure Society of American Research Fellowship

Patricia Rose Bigelow Book Prize, CSCP, UofT

Rohit Sheshgiri HSRLCE Studentship, UofT Medtronic Travel Award, CSCP, UofT University of Toronto Open Fellowship

Stjepan Soric Department of Physiology Fellowship, UofT NSERC Postgraduate Scholarship

Renee Suen Doctoral Thesis Completion Grant, UofT

19 Bigelow Book Prize Nomination, CSCP, UofT

Elissa Tepperman Ontario Graduate Scholarship OGSST/Heart & Stroke Foundation Scholarship University of Toronto Open Fellowship Institute of Medical Science Entrance Scholarship

Albert Tsui University of Toronto Open Fellowship A.C. Bryan Award for Best Poster, Shields Day Best Poster Award, Critical Care Medicine Meeting

Cindy Yip HSRLCE Travel Award BIOTECanada/TVG Student Scholarship, Technology Vision Group LLC and BIOTECanada Biopartnering Meeting HSRLCE Studentship University of Toronto Fellowship – Biomedical Engineering Centre of Theoretical Biological Physics Travel Award

Publications Alsoufi B, Karamlou T, Osaki M, Badiwala MV, Ching CC, Dipchand A, et al: Surgical repair of multiple muscular ventricular septal defects: The role of re-endocardialization strategy. J Thorac Cardiovasc Surg, 2006;132:1072-80.

Anderson CL, De Repentigny Y, Cifelli C, Marshall P, Renaud JM, Worton RG, Kothary R: The mouse dystrophin muscle promoter/enhancer drives expression of mini-dystrophin in transgenic mdx mice and rescues the dystrophy in these mice. Mol Ther, 2006;14(5):724-34.

Arab S, Gramolini AO, Ping P, Kislinger T, Stanley B, Van Eyk J, Ouzounian M, et al: Cardiovascular proteomics: Tools to develop novel biomarkers and potential applications. JACC, 2006;48(9):1733-41.

Badiwala MV, Rao V: Tricuspid valve surgery after cardiac transplantation. Curr Opin Cardiol, 2007;22:123-7.

Cifelli C, Bourassa F, Gariepy L, Banas K, Benkhalti M, Renaud JM: KATP channel deficiency in mouse flexor digitorum brevis causes fiber damage and impairs Ca2+ release and force development during fatigue in vitro. J Physiol, 2007;582(2):843-57.

Hansmann G, Wagner RA, Schellong S, de Jesus Perez VA, Urashima T, Wang L, Suen RS, Stewart DJ, Rabinovitch M: Pulmonary artieral hypertension is linked to insulin resistance and reversed by PPARγ activation. Circulation, 2007;115:1275-84.

Jackman J, Noesthodan M, Moffat D, Pezacki J, Findlay S, Ben R: Assessing antifreeze activity of AFGP8 using domain recognition software. Biochem Biophys Res Commun, 2007;354(2):340-4.

Lekas M, Lekas P, Latter DA, Kutryk MJB, Stewart DJ: Growth factor-induced therapeutic neovascularization for ischaemic vascular disease: Time for a re-evaluation? Curr Opin Cardiol, 2006;21:376-84.

20 Leung R, Gwozdz AM, Wang H, Bang KWA, Packham MA, Freedman J, Rand ML: Persistence of procoagulant surface expression on activated human platelets: Involvement of apoptosis and aminophospholipid translocase activity. J Throm Haemost, 2007;5:560-70.

Lui S, Wang W, Moos E, Jackman J, Mealing G, Monnet R, Ben RN: In vitro studies of antifreeze glycoprotein (AFGP) and a C-linked AFGP analogue. Biomacromolecules, 2007;8(5):1456-62.

Maekawa Y, Ouzounian M, Opavsky MA, Liu P: Connecting the missing link between dilated cardiomyopathy and viral myocarditis: Virus, cytoskeleton, and innate immunity. Circulation, 2007;115(1):5-8.

McCarter SD, Mei SH-J, Lai PFH, Zhang QW, Parker CH, Suen RS, et al: Cell-based angiopoietin-1 gene therapy for the acute respiratory distress syndrome. Am J Respir/Crit Care Med, 2007;175:1014-26.

McLaren A, Marsden PA, Mazer CD, Baker AJ, Stewart DJ, Tsui A, et al: Increased expression of HIF-1α, nNOS and VEGF in the cerebral cortex of anemic rats. Am J Physiol, Regul Integr Comp Physiol, 2007;292(1):R403-14.

O’Donnell E, Harvey PJ, Goodman JM, De Souza MJ: Long term estrogen deficiency lowers calf blood flow, resting systolic blood pressure and heart rate in premenopausal exercising women. Am J Physiol Endocrinol Metab, 2007;292(5):E1401-9.

Ouzounian M, Hasson A, Johnstone DEJ, Cox J, Howlett J: The effect of spironolactone use on heart failure mortality: A population-based study. J Card Fail, 2007;13(3):165-9.

Ramzy D, Rao V, Tumiati LC, Xu N, Sheshgiri R, Jackman J, Delgado DH, Ross HJ: Endothelin-1 accentuates the proatherosclerotic effects associated with C-reactive protein. J Thorac Cardiovasc Surg, 2007;133:1137-46.

Rose P, Hudson C: Comparison of arteriolar and venular variability in retinal blood flow measurements. Microvasc Res, 2007;73:35-8.

STUDENT ASSOCIATION SPONSORED ACTIVITIES Circulation Rounds The CSCP Student Association organizes and runs this event which highlights the diverse nature of research carried out by our faculty. These academic rounds rotate through the various research sites at the University of Toronto and each event is hosted by a faculty member where their research focus is the topic of the day. The goal of this event is to provide graduate students, post-doctoral fellows, research associates, undergraduates and project/summer students with the chance to develop an appreciation of the vast range of excellent research being conducted in our widespread community.

The first Circulation Rounds for the 2006-2007 academic year and the 9th Circulation Rounds overall took place in the Terrence Donnelly Cardiovascular Laboratories at St. Michael’s Hospital, Toronto on November 6, 2006. Dr. David Courtman was the speaker for the evening, who presented an interesting talk entitled “Vascular Biology of Arterial Aneurysms.” Dr.

21 Courtman discussed the rising prevalence in the last few decades of abdominal aortic aneurysms, predominately in the aging male population. Human abdominal aortic aneurysms have very disorganized collagen structures and Dr. Courtman described how his laboratory is now using laser capture microscopy to examine smooth muscle cells from abdominal aortic aneurysm samples and elucidate their gene expression profiles compared to the whole structure. He also presented a very helpful synopsis on vascular remodeling as a whole and thoroughly illustrated how remodeling is an adaptive response which depends on the extent and direction of rearrangement of vascular matrix and the balance of this response can lead to either stenosis (inward remodeling) or aneurysm (outward remodeling) formation. The event was well attended by a variety of research enthusiasts, largely consisting of students, post-doctoral fellows and research associates. The topic brought forth much discussion as there was a lot of interest in the development of and treatments for aneurysms.

On February 19, 2007 the second Circulation Rounds was held at the Toronto Western Hospital in the lab of Dr. Chris Hudson. Dr. Hudson, jointly appointed with the School of Optometry, University of Waterloo, and the Department of Ophthalmology and Vision Science, University of Toronto, spoke on "Retinal Blood Flow in Health and Disease". He outlined the methodology used in his lab to non- invasively measure retinal blood flow in patients and in healthy subjects. His talk focused specifically on diabetic retinopathy and he emphasized how careful categorization of the stage of diabetic eye disease and absolute flow measurements have allowed the discovery of vascular changes in pre-retinal edema patients. He also described how the treatment of diabetic eye disease has undergone rapid advancement, and his future research plans to investigate retinal metabolism, and the assessment of new diabetes treatments.

The third Circulation Rounds seminar of the 2006-07 academic year was held at the Toronto General Hospital on April 2, 2007. The speaker for this event was Dr. Vivek Rao, the Surgical Director of the Heart Transplant Program and an Associate Professor of Surgery at the University of Toronto. Dr. Rao’s talk, entitled “Contemporary Issues in Cardiac Transplantation” focused on a discussion of the symptoms and management of patients suffering from end stage heart failure. He also described the research being conducted in his laboratory, including mechanisms of endothelial dysfunction caused by immunosuppressive therapy, and the search for induction and detection of cardiac allograft tolerance in heart transplant patients.

ACKNOWLEDGEMENTS

The Cardiovascular Sciences Collaborative Program would like to thank the following sponsors for their generous support: Heart & Stroke Foundation of Ontario, Medtronic Canada, Biovail Pharmaceuticals Canada, Bristol-Myers Squibb Company, Aventis Pharma

22 FACULTY

Faculty are divided into 3 categories (Full, Associate, Affiliate). Details on faculty research interests and contact information are available on the web site. Departmental affiliations listed are those within the CSCP.

Name Departmental Affiliation(s) Location Full Lee Adamson BME/IMS/PSL Mount Sinai Hospital Khosrow Adeli LMP Hospital for Sick Children Jaques Belik IMS/PSL Hospital for Sick Children Michelle Bendeck LMP/Medicine UofT – MSB Sandra Black IMS Sunnybrook Health Centre Douglas Bradley IMS/Medicine Toronto General Hospital Dina Brooks REH UofT – Rehabilitation Science John Coles IMS/Surgery Hospital for Sick Children Philip Connelly LMP/Medicine St. Michael’s Hospital David Courtman BME/Surgery St. Michael’s Hospital Paul Dorian IMS/Medicine/PCL St. Michael’s Hospital Daniel Drucker IMS/LMP Mount Sinai Hospital C. Ross Ethier BME UofT – Mechanical Engineering John Flanagan IMS Toronto Western Hospital John S. Floras IMS/Medicine Mount Sinai Hospital Christopher Forrest IMS/Surgery Hospital for Sick Children Stephen Fremes IMS/Surgery Sunnybrook Health Centre Eser Fuller-Thomson Social Work UofT Adria Giacca PSL UofT - MSB Jack M. Goodman EXS UofT - Physical Ed & Health Len S. Goodman EXS Def & Civil Inst Environ Med Avrum I. Gotlieb LMP Toronto General Hospital Aleksander Hinek IMS/LMP Hospital for Sick Children David Hampson Pharmaceutical Science UofT – Pharmacy Margaret Hough IMS Sunnybrook Health Centre Chris Hudson IMS Toronto Western Hospital Mansoor Husain IMS/LMP/Medicine Toronto General Hospital K. Wayne Johnston BME/IMS/Surgery Toronto General Hospital Peter G. Kalman IMS/Surgery Community Fred Keeley LMP Hospital for Sick Children B. Lowell Langille LMP Toronto General Hospital Michelle Letarte MBP Hospital for Sick Children Gary F. Lewis IMS/Medicine Toronto General Hospital Ren-Ke Li IMS/LMP/Surgery Toronto General Hospital Peter Liu IMS/Medicine Toronto General Hospital Marius Locke EXS/CHL UofT – Physical Ed & Health Peter McLaughlin IMS/Medicine Toronto General Hospital Alan Moody BME/IMS Sunnybrook Health Centre David Naylor IMS/Medicine/CHL/Surgery UofT – MSB Heyu Ni LMP St. Michael’s Hospital

23 Peter O’Brien PHM UofT - Pharmacy Matadial Ojha BME/Surgery UofT – Rosebrugh Bldg. John Parker IMS/Medicine Mount Sinai Hospital Tom Parker IMS/Medicine Toronto General Hospital Margaret Rand IMS/LMP Hospital for Sick Children Vivek Rao IMS/Surgery Toronto General Hospital Michael Sefton BME UofT – Wallberg Bldg. Craig Simmons BME UofT – Mechanical Engineering Arthur S. Slutsky IMS/Medicine/Surgery Mount Sinai Hospital Donna E. Stewart Anesthesia/IMS/Surgery/Medicine Toronto General Hospital Duncan Stewart IMS/LMP/Medicine St. Michael’s Hospital Bradley Strauss LMP/Medicine St. Michael’s Hospital Howard Tenenbaum Dentistry UofT - Dentistry Scott G. Thomas EXS/PSL UofT – Physical Ed & Health George Tomlinson CHL Toronto General Hospital Jack Tu HPME Sunnybrook Health Centre Robert Wald IMS/Medicine Mount Sinai Hospital Judy Watt-Watson Nursing UofT - Nursing Richard D. Weisel IMS/Surgery Toronto General Hospital Peter Wells PHM UofT - Pharmacy Gregory Wilson IMS/LMP/PSL/Surgery Toronto General Hospital Carin Wittnich IMS/PSL/Surgery UofT - MSB Graham Wright MBP Sunnybrook Health Centre Shirley Wu PHM UofT - Pharmacy Tai-Wing Wu LMP Toronto General Hospital Burton Yang LMP Sunnybrook Health Centre Terry Yau IMS/Surgery Toronto General Hospital Erik L. Yeo IMS/Medicine Toronto General Hospital Yeni Yücel LMP St. Michael’s Hospital

Associate Joel Fisher Anesthesia Toronto General Hospital Gil Gross IMS Hospital for Sick Children Gregory Hare PSL St. Michael’s Hospital Scott Heximer PSL UofT - MSB William Hutchison PSL Toronto Western Hospital Jane Irvine CHL Toronto General Hospital Valery Leytin LMP St. Michael’s Hospital Tom Lindsay IMS/Surgery Toronto General Hospital Steffen-Sebastian Bolz PSL UofT - MSB

Affiliate Jagdish Butany LMP/Medicine Toronto General Hospital Gideon Cohen Surgery Sunnybrook Health Centre Chris M. Feindel Surgery Toronto General Hospital David Mazer Anesthesia/IMS St. Michael’s Hospital Patricia Murphy Anesthesia Toronto General Hospital

24 PEER REVIEWED FUNDING

Name Agency Title Adamson, L CIHR-Maintenance Maintenance of the advanced bioimaging centre (2006-11) CIHR-Group Development and fetal health (2005-10) CIHR-Equip Cardiovascular phenotyping in embryonic and newborn mice /Maintenance (2005-10) CIHR-Operating Generation and physiological analysis of genome-wide mutations in mice (2004-09) CIHR-Operating Cardiovascular phenotyping in embryonic and newborn mice (2004-08) CIHR-Resource Canadian mouse mutant repository: a core resource for mouse models of human disease (2006-11) CIHR-Operating A murine model to investigate the mechanisms underlying DOHαD (2006-09) CIHR-Healthy Fetal growth restriction: mechanisms and outcomes (2005-10) Pregnancy Program Centre for modeling human disease (2004-09) CIHR-Group Three dimensional quantification of the placenta vascular tree: HSFC-Grant-in-Aid relationship with normal and abnormal fetal growth and hemodynamics (2006-08) Adeli, K HSFO-Operating Mechanisms of hepatic VLDL overproduction in insulin resistance (2007-12) NSERC-Operating Translational control of apolipoprotein B mRNA (2007-12) CIHR-Operating Mechanisms of intestinal lipoprotein production and deregulation in insulin resistant states (2005-10) HSFO-Operating Mechanisms and regulation of apolipoprotein B degradation (2005-09) HSFO-Operating Mechanisms of VLDL overproduction in insulin resistance (2004-07) NSERC-Operating Translational control of apolipoprotein B mRNA (2002-07) Belik, J CIHR-Operating Airway modulation of pulmonary vascular tone during development and following pulmonary hypertension (2004-09) Group in lung development (2004-09) CIHR-Group Endothelial eNOS uncoupling and role of BMP-9 in the HSFO-Operating regulation of pulmonary vascular tone during development and following pulmonary hypertension (2007-09) Functional MR imaging for early detection and physiologic RSNA Research & characterization of inflammatory arthritis in a rabbit model Education Foundation (2006-07) Bendeck, M HSFO The effect of doxycycline on the smooth muscle cell response to injury (2004-07) CIHR The role of discoidin domain receptors in atherosclerosis (2003- 07) HSFO Cadherins and regulation of smooth muscle function (2004-07) The cell biology of atherosclerosis group grant (2005-10) HSFO Discoidin domain receptor 1 in atherosclerosis (2007-09) HSFO The role of type VIII collagen in vascular disease (2006-11) CIHR Cadherins and regulation of smooth muscle cell function (2007- HSFO 12) Bolz, SS HSFO Mechanisms that regulate the pressure-dependent activation of the sphingosine-1-phosphate signalling pathway in resistance arteries CFI & ORI Role of subcellular localization of key sphingosine-1-phosphate (S1P)-related signalling proteins in microvascular function

25 Name Agency Title Bolz, SS CIHR Caveolae-Location of the interaction between endogenous (cont’d) sphingosine-1-phosphate and Kv channels in vascular smooth muscle cells that modulates the contractility of small resistance arteries Deutsche Forschung- Caveolen als Orte der konstriktions-modulierenden Sgemeinschaft (DFG) Wechselwirkung zwischen endogenem Sphingosin-1-Phosphat und Kv Kanalen glatter Muskelzellen in isolierten WiderstandsgefBen Connaught Novel mechanisms determining the activation state of Sphingosine kinase in resistance arteries Brooks, D Christian Blind Mission Factors contribute to success in raising major funds for International international NGO’s (2006-07) Ontario Neurotrauma Partners in fitness: A pilot program to enhance community Foundation integration in adults with brain injury (2006-07) HSFO Cardiac rehabilitation for individuals after stroke (2006-09) Lung Association Crossing the chasm – More inspiratory muscle training for people with COPD (2006-07) Physiotherapy Fdtn Evidence-based suctioning: A systematic review (2006-07) Ontario Lung Assoc Satisfaction with rollators among individuals with COPD living in the community (2006-07) CIHR The personal therapist: A smart ambulatory monitoring system to facilitate recovery following stroke (2006-09) CIHR Timely access and seamless transitions in rural palliative/end of life care (2006-11) CIHR Improving sensorimotor recovery, aerobic capacity and functional walking (2006-09) Butany, J CIHR Team Grant Chronic total occlusion (2006-09) NSERC/CIHR/CHRP Local tissue changes in dilated ascending aortas (2005-08) Connelly, HSFO Molecular mechanisms for oxidation of high density lipoproteins PW (2006-08) HSFO Comparative studies of paraoxonase 1 and paraoxonase 3 (2005-08) CIHR Longitudinal associations of adipocytokines and markers of sub-clinical inflammation with changes in insulin resistance and beta-cell function in women with a history of gestational diabetes mellitus (2004-07) Dorian, P Ministry of Health: Long Selective strategy to manage arrhythmia risk and therapy with Term Care Res Prog ICD (2007-12) Fisher, JA CIHR Multi-modal imaging studies of the relationship between age, physical activity level, cerebral physiology, and cognitive performance (2007-11) Floras, J CIHR CIHR Tier I Chair (2004- ) HSFO Career investigator Award (2001-11) HSFO-Program Multidisciplinary group for the investigation and therapy of human cardiovascular disease (2003-08) CIHR Cardiovascular, autonomic and neurohormonal impact of nocturnal hemodialysis (2005-10) CIHR Pathophysiology sleep apnea in heart&renal failure (2007-12) HSFO Effects of continuous positive airway pressure on myocardial energetics and sympathetic nerve function in patients with heart failure and obstructive sleep apnea (2005-08) Forrest, CR CIHR-Operating Global protection of skeletal muscle against ischemic necrosis and vascular dysfunction by non-invasive remote ischemic preconditioning: Efficacy and mechanism (2003-2006)

26 Name Agency Title Forrest, CR CIHR Perioperative protection and post-ischemic salvage of skeletal (cont’d) muscle from ischemia/reperfusion injury (2005) Fremes, S CIHR Blood conservation using antifibrinolytics: A randomized trial in high risk cardiac surgery – The BART Trial Canada Fdtn for Imaging Research Centre for Cardiac Intervention – IRCCI Innovation CIHR Multicentre radial artery patient study: 5 year results CIHR Biochemical and genetic predictors of coronary bypass graft atherosclerosis HSFO Graft imaging to improve patency (GRIIP) study HSFO Unraveling the black box of adverse events in cardiac surgery NHLBI FREEDOM Trial – Future revascularization evaluation in patients with diabetes mellitus: optimal management of multivessel disease Giacca, A HSFC Anti-atherogenic effect of insulin (2005-08) CDA Mechanisms of fatty acid induced insulin resistance (2004-06) CIHR Interaction between lipotoxicity and glucotoxicity on glucose stimulated insulin secretion (2004-07) CIHR Glucose toxicity: prevention of complications and preservation of beta cell function (2002-07) NSERC Investigation of the biological effects of the polyphenol resveratrol on skeletal muscle glucose transport (2004-07) Gotlieb, AI HSFO Cell biology of atherosclerosis (2005-10) CIHR The endothelium in atherogenesis: Influences of hemodynamic stresses (2001-06) HSFO Cell biology of heart valve interstitial cells (2007-09) Gramolini, A HSFO Molecular basis of phospholamban regulation and function (2006-08) Genome Canada Protein biomarkers in cardiovascular disease (2004-07) HSFO New investigator Gross G CIHR Characterization of circulating effectors and temporal profiling of remote ischaemic preconditioning (2006-09) HSFO Ventricular repolarization in complete heart block (2004-07) HSFO Contractile and electrophysiologic adaptations to constrained heart rate conditions (2006-08) CIHR Molecular expression and physiology in developing atrioventricular nodal cells (2006-09) HFSO Ventricular repolarization in bradycardic electrical remodeling (2007-10) Hare, G Bristol-Myers Squibb- Mechanisms of cerebral protection and injury during acute Career Scientist Award hemodilutional anemia (2005-08) Soc Cardiovascular The threshold hematocrit for cerebral hyposia is maintained by Anesthesiologists protective cardiovascular mechanisms: The role for neuronal metric oxide synthase (nNOS) (2007-09) Can Anesthesiologist’ Does beta-1 adrenergic antagonism increase tissue hypoxia Soc Wynands Res following acute hemodilution? (2007-08) Award Hinek, A CIHR-Operating Elastin and elastin receptor in pathobiology of cardiovascular disease (2006-11) HSFO-Operating Elastin and elastin receptor in control of cellular proliferation (2003-08) Human Matrix Sciences Comparison of biological effects of different preparations of elastin-derived peptides on skin fibroblasts (2004-08) HSFC Career Investigator Award (2004-07)

27 Name Agency Title Hinek, A HSFC-Operating Aldosterone receptor and non-receptor based mechanism of (cont’d) repair and remodeling following cardiac injury (2004-07) Hudson, C HSFC Age-related changes in retinal vascular autoregulation in normal and atherosclerotic patients (2003-2006) Glaucoma Res. Society Retinal vascular reactivity in response to isoxic hypercapnia in primary open-angle glaucoma (2005-2006) CIHR-Operating Sight-threatening retinal complications in type 2 diabetes (2005-2010) Canada Fdtn Establishment of a multi-disciplinary laboratory for the research Innovation of sight-threatening diabetic retinopathy (2000-2006) CIHR-New Investigator Pre-clinical detection, and improved monitoring, of early sight- threatening diabetic retinopathy (2001-2006) Husain, M HSFO-Operating Role of glucagons-like peptides in cardiac health and disease (2006-09) CIHR- Operating c-Myb-dependent vascular smooth muscle cell proliferation (2004-09) CIHR-Operating The role of plasma membrane Ca2+-ATPase isoforms in vascular smooth muscle cell biology (2003-08) HSFO-Operating Controlling bioreactor condition to optimize regenerative potential of cardiomyocytes (2007-09) CIHR-Operating Pathophysiological relevance of endothelin-1 (2005-10) HSFO-Operating Targeted over-expression of inducible NO synthase: relevance for the pathogenesis of cardiovascular disease (2005-08) CIHR-Operating Role of ACE2 in the regulation of cardiac and vascular function (2003-08) HSFO-Group Cell biology of atherosclerosis (2005-10) CIHR-Group Determinants of host susceptibilities of heart failure (2003-08) Hutchison, CIHR Neurophysiological studies of human subthalamic nucleus WD (2004-09) Irvine, MJ HSFO Self-monitoring of blood pressure in primary care in older (45+years) diabetic patients with uncontrolled systolic hypertension (2006-09) HSFO Psychological support for patients with an implantable cardioverter defibrillator (2006-08) CIHR Longitudinal Canadian Alzheimer’s disease quality of life study (2005-06) CIHR Sexual dysfunction and adaptation in couples affected by prostate cancer surgery: steps towards a biopsychosocial model of treatment (2005-08) Keeley, F CIHR Molecular determinants of elastin self-assembly and mechanical properties (2007-10) HSFO Recombinantly expressed polypeptides of human elastin as a novel tool for investigations of the structure and assembly of elastin (2004-09) HSFO A combined theoretical/experimental approach to understanding sequence-structure-function relationships in elastin and elastin-like peptides (2005-07) (2007-09) NSERC Non-collagenous cartilages: Matrix proteins, development, physical properties and phylogeny (2005-10) CIHR(MRC) Post-transcriptionsl regulation of vascular elastin synthesis in development and disease (2006-07) AFMNet Controlling peptide self-assembly: approaches to the rational design of nanostructured food-derived materials (2006-09)

28 Name Agency Title Langille, L CIHR-Operating Influence of hemodynamics on arterial endothelium (2001-06) HSFO-Operating Arterial responses to hemodynamic stresses (2002-07) HSFO-Operating Cadherins and regulation of smooth muscle cell function (2004- 07) CIHR A new concept underlying the control of myometrial contractility during pregnancy (2005-10) HSFO-Group Cell biology of atherosclerosis (2005-10) CIHR-Group Development and fetal health (2005-10) Letarte, M HHT Foundation Int’l TGF-β activates eNOS and regulates vasomotor function by an endoglin-and ALK-1-dependent mechanism (2006-07) CIHR-Operating Endoglin, ALK-1 and BMPRII networks: role in vascular disorders (2005-10) HSF Role of endoglin in the normal vasculature and in the pathology of hereditary hemorrhagic telangiectasia (2005-09) CIHR-Operating Functional characterization of androgen-altered genes with a putative role during early events in ovarian carcinogenesis (2005-09) NIH-Operating Physiology of systemic and pulmonary microangiectasias (2003-07) HSFO eNOS uncoupling and role of bone morphogenetic protein in the regulation of pulmonary vascular tone during development and following pulmonary hypertension (2007-09) Dept Defense (USA) Fallopian tube epithelial cells as a source of serious cancer in BRAC mutation carriers (2006-09) Leytin, V HSFC Platelet apoptosis induced by chemical agonists and shear stresses (2005-08) CIHR Use of normal physiologic inhibitors of matrix metalloproteinases to improve viability and function of platelet concentrates (2006-09) Li, R-K HSFO-Personnel Cell transplantation for cardiovascular disease (2001-06) Ont Min Energy, Sci Cell transplantation to improve heart function (2001-06) CIHR Autologous tissue-engineered grafts for congenital heart surgery (2003-08) HSFO Vasculogenesis induced by cell transplantation (2003-07) HSFO Gene-enhanced cell transplantation to reverse heart failure (2004-07) Ont Min Agriculture and Functionality of resistant starch and bioactive peptides in Food/Univ. of Guelph preventing chronic diseases and promoting gut functions in Food Res. Program studies with the pig model (2004-08) CIHR The interplay of recruited stem cells and the matrix after myocardial infarction: shifting balance toward repair (2004-09) NSERC Development of a new, portable biomedical device for in vivo measurement of regional heart tissue elasticity (2004-07) CIHR Interplay of recruited stem cells and the matrix after myocardial infarction: Shifting the balance toward repair (2004-09) NSERC Development of a new, portable biomedical device for in vivo measurement of regional heart tissue elasticity (2004-07) Liu, PP Genome Canada Biomarkers in cardiovascular disease (2005-08) CIHR Gene-environment factors in heart failure (CHFNET) (2002-07) CIHR Host response patterns in heart failure (CHF-CORE) (2003-08) CIHR Molecular mechanisms of viral myocarditis (2004-09) CIHR Cytokines in heart failure (2006-10) CIHR Oxidative stress and iron overload cardiomyopathy (2006-10) HSF Chlamydia and atherosclerosis: Immune insights (2003-08)

29 Name Agency Title Liu, PP HSF Danger signal and host immune response (2006-10) (cont’d) HSF Role of inflammation in stem cell homing post cardiac injury (2006-09) Mazer, CD PSI High fidelity simulation versus traditional didactic seminars for teaching trainees separation from cardiopulmonary bypass (2006-08) HSFO Unravelling the black box of adverse events in cardiac surgery (2006-09) Ni, H HSFO Novel mechanisms of platelet aggregation: roles of alternative ligands of β3 integrins in thrombosis and hemostasis (2005-08) CIHR Pathogenesis of fetal and neonatal alloimmune thrombocytopenia and mechanism of action of IVIG in a novel mouse model (2004-07) CIHR-Cdn Blood Investigation of pathogenesis of immune thrombocytopenia and Services efficacy and mechanism of action of intravenous IgG (OVOG) (2006-09) CIHR/Cdn Blood Study of fetal and neonatal alloimmune thrombocytopenia in a Services novel mouse model and investigation of efficacy and mechanisms of action of IVIG in these disorders (2006-07) HSFC Investigation of lysophospatidic acid (LPA) generation and platelet function in newly developed lpdlr phospholipase deficient mice (2007-09) Parker, T CIHR Role of S100B-dependent pathways in the cardiac response to disease (2005-10) CIHR Regulation of cardiac structure and function by the EF-hand proteins, S100A1 and S100A6 (2003-07) CIHR Coordinated original research in elucidation of mechanisms in heart failure (CORE-CHF) (2003-08) CIHR-Team Dysfunctional endothelial cell repair in diabetes: pathogenetic mechanisms and regenerative strategies (2007-12 Rand, M HSFO Procoagulant surface of activated platelets: Persistence in vivo and in vitro Rao, V CIHR The influence of heart failure on the organization of human ventricular fibrillation HSFC Erythropoietin and hypertonic saline for cardiac transplantation HSFC Mechanisms of transplant related vascular injury Sefton, M ORDCF Establishment of an advanced reconstructive tissue engineering centre (2003-08) CIHR Tissue engineering: Immune response and vascularisation (2004-07) NSERC Tissue engineering (2003-08) CIHR Training program in regenerative medicine (2002-07) CIHR Quantum dot-based biomolecular imaging (2005-10) CIHR STIHR Program The cardiac regeneration (CARE) project (2006-11) CFI The regenerative medicine (REMEDI) project (2006-11) Simmons, C NSERC-CIHR Investigation of mesenchymal progenitor cell response to mechanobiological stimuli using a novel MEMS-based array platform (2006-09) NSERC-Discovery Heart valve cell biomechanics and mechanobiology (2006-11) NSERC-RTI Micropipette aspiration system for cell mechanics (2006-07) CFI-ORF Infrastructure for a state-of-the-art lab for cellular mechanobiology (2006-09) CRC Canadian Research Chair in mechanobiology (2006-11) Ont Early Researcher Tissue engineered heart valves (2006-11)

30 Name Agency Title Simmons, C Connaught New Staff Systematic investigations of control strategies for stem cell- (cont’d) based osteochondral tissue engineering (2005-07) Slutsky, AS CIHR Biotrauma: mechanisms of lung injury and distal organ dysfunction (2004-09) CIHR/HSFC Clinical research consortium to improve resuscitation outcomes: from bench to bedside to curbside (2004-09) Stewart, DE Ont Min Health Long Improving health and promoting equity for the women of and Term Care Ontario (2006-09) CIHR International comparisons of the perinatal health and care of migrant women (2006-07) CIHR Cardiovascular secondary prevention for vulnerable populations: an interdisciplinary approach to improving access to services and outcomes (2006-11) CIHR New mothers in a new country: understanding postpartum depression among recent immigrant and Canadian-born Chinese women (2006-07) CIHR Assessing the feasibility to measure and compare gender- sensitive mental health indicators in Peru, Colombia and Canada (2006-08) CIHR Neurochemical aspects of depression in women: monoamine oxidase A in the postpartum period (2007-10) CIHR Measuring and understanding gender equity in access to care (2006-09) Int Dev Res Centre Political violence, natural disasters and mental health outcomes: developing innovative health policies and interventions (2007-11) Public Health Agency Health indicator research (2006-07) Stewart, DJ HSFC AT-cell based immune mechanisms of clamydia vascular injury (2003-08) CIHR Coordinated original research in elucidation of mechanism in heart failure (CHF-CORE) (2004-09) CIHR Regenerative medicine and nanomedicine: innovative approaches in health research(NET) cardiovascular/respiratory stem cell plasticity (2004-09) CIHR Does nutrient supplementation influence cardiac structure and function following MI by altering energy metabolism? (2005-07) CIHR Pathophysiological relevance of endothelin-1 overexpression (2005-10) HSFC NO-synthase in cardiovascular health and disease (2005-08) HSFC Arterial remodeling (2005-07) HSFC Cell biology and atherosclerosis (2005-10) CIHR Microvascular endothelial cell loss in pulmonary arterial hypertension (2005-11) CIHR Effect of organic nitrates on osteoporosis (2005-11) PSI Stem cell factor/c-KIT axis is a novel target of vascular remodeling (2006-07) HSFC Molecular mechanisms for oxidation of high density lipoproteins in vivo (2006-08) CIHR Ultrasound-targeted gene delivery for therapeutic angiogenesis (2006-09) HSFC Site-targeted imaging & delivery cell-based therapy (2006-08) Genotype/phenotype of endothelial progenitor cells in CIHR pulmonary arterial hypertension ((2006-07) CIHR Role of angiopoietins in regulation of angiogenesis (2006-10)

31 Name Agency Title Weisel, RD HSF Cardiac regeneration by cell transplantation HSF Enhanced endogenous repair by cell therapy CIHR The cardiac regeneration project: Quantitative cell tracking and response for cardiac regenerative approaches (CARE project) CFI & ORS The regenerative medicine (REMEDI) project Wells, PG Methanol Fdtn (USA) Molecular basis of methanol developmental toxicity (2006-10) CIHR Toxicology of drugs bioactivated to a reactive intermediate (2007-12) CIHR Free radical determinants of meurodegenerative diseases (2005-10) NIH Fetal DNA oxidation and repair in neurodegeneration (2006-08) Wittnich, C HSFO Oxygen stress in newborn hearts (2003-07) CIHR Training program in cardiovascular research: Molecules to populations, heart failure to prevention (2002-07) HSFO Impact of gender on myocardial pathology & ischemia reperfusion (2004-08) Wright, GA CIHR Magnetic resonance imaging for ischemic heart disease (2003- 07) Ont Res Develop Fund Ontario consortium for cardiac imaging (2000-07) Cdn Fdtn Innovation Imaging research centre for cardiac intervention (2002-08) CIHR Microvessel formation in chronic total occlusions: pathophysiology and role in successful guide-wire crossing (2005-08) CIHR Centre for research using magnetic resonance at Sunnybrook and Women’s College Health Sciences Centre (2005-10) CIHR Magnetic resonance imaging for ischemia (2005-10) CIHR Development of an in vivo animal model and non-invasive high resolution imaging techniques for the study of atherosclerotic intraplaque haemorrhage (2006-09) CIHR ICRH New Frontiers Program in clinical imaging research (2007) CIHR CIHR team in occlusive vascular disease (2007-10) Cdn Fdtn Innovation Biomedical multimodality hybrid imaging (2007-11) Cdn Fdtn Innovation Regenerative medicine project (REMEDI) (2007-11) Yang, B CIHR Role of versican in angiogenesis (2005-08) CIHR-Health Canada Effect of the medicinal mushroom Ganoderma lucidum on tumor cell activities (2005-08) CIHR Versican in endothelial cell morphogenesis, adhesion, migration, and wound healing (2006-09) NSERC Product processing of proteoglycan versican (2006-11) Cdn Breast Cancer Analysis of microRNA functioning in breast carincoma (2006- Fdnt, Ont Chapter 09) Yang, B Sci Tech Dept, Translational research on Ganoderma lucidum (2004-07) (cont’d) Guangdong Gov Effects of microRNAs on the expression of angiogenic factors CIHR in hypoxia-stimulated cells during myocardial and cerebral ischemia, myocardial infarction and stroke (2006-09) Yücel, YH Glaucoma Res Society Vascular injury to vision brain centers mimics normal tension glaucoma (2006-07) Cdn Glaucoma Clinical Novel vision testing paradigms for patients with glaucoma Research Council (2006-07) Merck Frosst Canada Human glaucoma: Blood vessels and perivascular pathology (2006-07) CIHR Neuroprotective effects of memantine in monkey brains with early and moderate experimental glaucoma (2005-07)

32 AWARDS AND HONORS

NAME HONORS AND AWARDS Adamson, L - Anne and Max Tanenbaum Chair in Molecular Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital Bendeck, M - Career Investigator Award, Heart and Stroke Foundation of Ontario (2004-2009) Bolz, S - Ontario Hypertension Society Research Recognition Award - Microcirculatory Society August Krogh Award - APS Cardiovascular Section Recognition Award - HSRLCE Research Day Poster Award Brooks, D - Meritous Award of the Lung Association 2007 - Silver Quill Research Article Award of Excellence in Physiotherapy Canada 2006 - Recognition in Teaching Award, Dept. Physical Therapy, UofT 2006-06 - Nomination, Ontario Confederation of Universities Association (OCUFA) Teaching Award Butany, J - Vice President and President Elect, International Society for Cardiovascular Pathology (2005-07) - Vice President and President Elect, Canadian Association of Pathologists (2005-07) - President, Canadian Association of Pathologists (2006-08) Connelly, P - Certificate: Lipid Standardization Program for Total Cholesterol, Triglyceride and High Density Lipoprotein Cholesterol, Centers for Disease Control, National Heart, Lung, and Blood Institute Dorian, P Squires Club Mentorship Award, St. Michael’s Hospital, 2006 Fisher, JA - Abstract presented at Canadian Anesthesiology Society meeting; picked as “Top 50” - UofT medical student poster competition: Winner – Basic Science and Best Overall. Selected to represent UofT at the Eastern-Atlantic Student Research Forum, Miami, Florida - UHN Inventor of the Year 2005 Forrest, CR - Visiting Professor, John’s Hopkins School of Medicine, University of Maryland, Baltimore, 2006 - Professor, Division of Plastic Surgery, Dept. of Surgery, UofT, 2006 Gotlieb, AI - Canadian Academy of Health Sciences, Fellow - William Boyd Lectureship, Canadian Association of Pathology Hare, G - Canadian anesthesiologists’ Society, Best Presentation, Richard Knill research Award, 2007 Husain, M - Career Investigator Award, Heart & Stroke Foundation of Ontario (2004-09) Leytin, V - Associate Professor, Dept. of Laboratory Medicine and Pathobiology, UofT Li, R-K - Canada Research Chair in Cardiac Regeneration, 2006 - Career Investigator Award, HSFC - Chinese American Medical Society Scientific Award Liu, P - Eldon Smith Lectureship, University of Calgary, 2006 - Award of Merit, Federation of Chinese Canadian Professionals for Research, 2006 - Faculty of Medicine, Graduate Mentorship Award, University of Toronto, 2006 Murphy, P - Dr. Gerald Edelist Award for Postgraduate Teaching, Dept. of Anesthesia, UofT, 2006 Ni, H - Invited speaker/Travel Award, 4th Asia-Pacific Congress on thrombosis and Hemostasis (APCTH) Rand, M - Member, Board of Directors, Heart and Stroke Foundation of Ontario Sefton, MV - Fellow Royal Society of Canada - Invited Speaker, Dept of Chemical Engineering Centennial Celebration, Queen’s University - Keynote Speaker, UHN Science Day - Invited Speaker, American Association of Anatomists, FASEB, San Francisco Simmons, C - Early Researcher Award, Ministry of Research and Innovation, Government of Ontario Stewart, DE - Co-Chair, International Committee to Review Abuses of Psychiatry, World Psychiatric

33 Association (2006-12) - Inaugural Honorary Fellow, Canadian Psychiatric Association (2006-Present) - Elected to AOA, Faculty Member (2006-Present) - Institutional Advisory Board of CIHR Institute of Gender and Health (2006-09) - Senior Advisor to World Health Organization on Women’s Mental Health (2007-Present) Stewart, DJ - Recipient, St. Michael’s Hospital Philanthropy Award - Member, International Advisory Board of the Excellence Cluster Cardiopulmonary System (2007-12) Weisel, RD - Presenter, William W.L. Glenn Lecture, American Heart Association Scientific Session, 2006 Wells, PG - Grass Traveling Scientist Award, Saskatchewan Neuroscience Network and the University of Saskatchewan Wittnich, C - Chair, John Charles Polanyi Prizes Selection Committee, Ontario Council on Graduate Studies (2007) Wright, GA - Alan C. Burton Lecture, Dept. of Medical Biophysics, University of Western, London, Ontario Yang, B - Career Investigator Award, Heart and Stroke Foundation of Ontario - New Investigator Award, Canadian Institutes of Health Research Yücel, YH - Nominee, Alcon Institute Award - Nominee, Lewis Rudin Glaucoma Prize - Global Best Scientific Article Award 2006, Association of International Glaucoma Socieites

PUBLICATIONS Ahmad F, Hogg-Johnson S, Stewart DE, Levinson W: Violence involving intimate partners: Prevalence in Canadian family practice. Can Fam Physician, 2007;53:460-8.

Akikusa JD, Feldman BM, Gross JG, Silverman ED, Schneider R: Sinus bradycardia following intravenous ‘pulse’ methylprednisolone. Pediatrics, 2007;119:E778-82.

Alghamdi AA, Moussa F, Fremes SE: Does the use of preoperative aspirin increase the risk of bleeding in patients undergoing coronary artery bypass grafting surgery? Systematic review and meta-analysis. J Cardiac Surg, 2007;22(3):247-56.

Al-Hesayen A, Floras JS, Parker JD: The effects of intravenous sildenafil on hemodynamics and cardiac sympathetic activity in chronic human heart failure. Eur J Heart Fail, 2006;8:864-8.

Al-Kwifi O, Farb R, Stainsby J, Wright GA: Evaluating contrast kinetics by acquiring 2D images during 3D contrast-enhanced MR angiography. J Magn Reson Imaging, 2006;24(2):434-8.

Al-Kwifi O, Shelef I, Farb RI, Stainsby J, Wright GA: High resolution imaging of the intracranial arterial and venous system following a single contrast injection. J Magn Reson Imaging, 2006;24(2):267-73.

Al-Kwifi O, Stainsby J, Foltz W, Sussman MS, Huang Y, Wright GA: Characterizing coronary motion and its effect on MR coronary angiography. J Magn Reson Imaging, 2006;24(4):842-50.

Allo JC, Beck JC, Brander L, Brunet F, Slutsky AS, Sinderby CA: Influence of neurally adjusted ventilatory assist and positive end-expiratory pressure on breathing pattern in rabbits with acute lung injury. Crit Care Med, 2006;34(12):2997-3004.

34 Anand N, McCrindle BW, Chiu-Man C, Hamilton RM, Kirsh JA, Stephenson E, Gross GJ: Chronotropic incompetence in young patients with late-postoperative atrial flutter: A case-control study. Eur Heart J, 2006;27:2069-73.

Arab S, Gramolini AO, Ping P, Kislinger T, et al, Liu PP: Cardiovascular proteomics: Tools to develop novel biomarkers and potential applications. J Am Coll Cardiol, 2006;48:1733-41.

Arnold JM, Howlett JG, Dorian P, Ducharme A,…Liu P, Mann E, McKelvie RS, Moe GW, Parker JD,…Rao V, Sequeira EJ, White M: Canadian Cardiovascular Society Consensus Conference recommendations on heart failure update 2007: Prevention, management during intercurrent illness or acute decompensation, and use of biomarkers. Can J Cardiol, 2007;23(1):21-45.

Arribas SM, Hinek A, González C: Elastic fibers and vascular structure in hypertension. Pharmacol Therap, 2006;111(3):771-91.

Arzt M, Floras JS, Logan AG, Kimoff J,…Tomlinson G, Bradley TD, for the CANPAP Investigators: Suppression of central sleep apnea by continuous positive airway pressure and transplant-free survival in heart failure – a post hoc analysis of CANPAP. Circulation, 2007;115:3173-80.

Arzt M, Young T, Finn L, Skatrud JB,…Parker JD, Floras JS, Bradley TD: Sleepiness and sleep in patients with both systolic heart failure and obstructive sleep apnea. Arch Intern Med, 2006;166:1716-22.

Ayach B, Yoshimitsu M, Dawood F, Sun M,…Liu PP: Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction. Proc Nat Acad Sci USA, 2006;103:2304-9.

Azizi B, Buehler H, Venkataraman ST, Hudson C: Impact of simulated light scatter upon the quantitative, non-invasive assessment of retinal arteriolar hemodynamics. J Biomed Optics, 2007;12:1-6.

Badiwala M, Rao V: Tricuspid valve replacement after cardiac transplantation. Curr Opin Cardiol, 2007;22:123-7.

Belik J, Hehne N, Pan J, Behrends S: Soluble guanylate cyclase-dependent relaxation is reduced in the adult rat bronchial smooth muscle. Am J Physiol Lung Cell Mol Physiol, 2007;292(3):699-703.

Bentkover JD, Dorian P, Thibault B, Gardner M: Economic analysis of a randomized trial of biventricular pacing in Canada. Pacing Clin Electrophysiol, 2007;30(1):38-43.

Bhuller Y, Jeng W, Wells PG: Variable in vivo embryoprotective role for ataxia telangiectasia- mutated (ATM) against constitutive and phenytoin-enhanced oxidative stress in atm knockout mice. Toxicol Sci, 2006;93(1):146-55.

Bhuller, Wells PG: A developmental role for ataxia telangiectasia-mutated (ATM) in protecting the embryo from spontaneous and phenytoin-enhanced embryopathies in culture. Toxicol Sci, 2006;93(1):155-63.

35 Blackmore ER, Carroll J, Reid A, Biringer A,…Stewart DE: The use of the antenatal psychosocial health assessment (ALPHA) tool in the detection of psychosocial risk factors for postpartum depression: A randomized controlled trial. J Obstet Gynaecol Can, 2006;28:873-8.

Body SC, Mazer CD: Pro: Aprotinin has a good efficacy and safety profile relative to other alternatives for prevention of bleeding in cardiac surgery. Anesth Analg, 2006;104(6):1354-9.

Borger MA, Murphy PM, Alam A, Fazel S, Maganti M, Armstrong S, Rao V, David TE: Initial results of the chordal cutting operation for ischemic mitral regurgitation. J Thorac Cardiovasc Surg, 2007;133:1483-92.

Bronzetti G, Chiu C, Stephenson EA, Gross GJ, Hamilton RM, Dong-Sheng G, Neilson AL, Kirsh JA: Simultaneous wide and narrow QRS complex tachycardias in a child: What is the mechanism? J Cardiovasc Electrophysiol, 2006;17:1-3.

Brooks D, Davis A, Naglie G: The feasibility of six-minute and two-minute walk tests in inpatient geriatric rehabilitation. Can J Aging, 2007;26:159-62.

Brooks D, Davis AM, Naglie G: Validity of three physical performance measures in inpatient geriatric rehabilitation. Arch Phys Med Rehabil, 2006;87(1):105-10.

Brooks D, MacKay-Lyons M: Survival of the fittest: The role of exercise in physiotherapy practice. Physiother Can, 2006;58(1):1-2.

Brooks D, Solway S: Should the endurance shuttle walk test replace the six-minute walk test in individuals with chronic obstructive pulmonary disease? Chron Respir Dis J, 2006;3:1-2.

Brooks D, Sottana R, Bell B, Hanna M, Laframboise L, Selvanayagarajah S, Goldstein R: Characterization of pulmonary rehabilitation programs in Canada in 2005. Can Respir J, 2007;14:87-92.

Bunda S, Liu P, Wang Y, Liu K, Hinek A: Aldosterone induces elastin production in cardiac fibroblasts through activation of IGF-1 receptor in MR-independent manner. Am J Pathol, 2007;171:809-19.

Bureau W, Van Slyke P, Jones J, Han RNN, Stewart DJ, Dumond D: Chronic systemic delivery of angiopoietin 2 reveals a possible independent angiogenic effect. Am J Physiol Heart Circ Physiol, 2006;291(2):H948-56.

Burra TA, Chen E, McIntyre RS, Grace SL, Blackmore ER, Stewart DE: Predictors of self- reported antidepressant adherence. Behav Med, 2007;32:127-34.

Butany J: Left atrial myxoma presenting as acute inferior wall infarction-a case report. J Cardiac Surg, 2006;21(5):479-80.

Butany J, Bahl NE, Morales K, Thangaroopan M, Ross H, Rao V, Leong SW: The intricacies of cardiac sarcoidosis: A case report involving the coronary arteries and a review of the literature. Cardiovasc Pathol, 2006;15(4):222-7.

36 Butany J, Dev V, Leong SW, Soor GS, Thangaroopan M, Borger MA: Infective endocarditis of the tricuspid valve. J Cardiac Surg, 2006;21(6):603-4.

Butany JW, Kesarwani R, Yau TM, Singh G, Thangaroopan M, Nair V, Leong SW: The role of pannus in the longevity of an Ionescu-Shiley pericardial bioprosthesis. J Cardiovascular Sciences Collaborative Program Surg, 2006;21(5):505-7.

Butany J, Leask RL, Desai ND, Jegatheeswaran A, Silversides C, Scully HE, Feindel C: Pathologic analysis of 19 heart valves with silver-coated sewing rings. J Cardiovascular Sciences Collaborative Program Surg, 2006;21(6):530-8.

Butany J, Leung SW, Cunningham KS, D’Cruz G, Carmichael K, Yau TM: A 10-year comparison of explanted Hancock-II and Carpentier-Edwards supraannular bioprostheses. Cardiovasc Pathol, 2007;16(1):4-13.

Butany J, Leung SW, Rao V, Borger MA, David TE, Cunningham KS, Daniel L: Early changes in bioprosthetic heart valves following ventricular assist device implantation. Int J Cardiol, 2007;117(1):e20-3. [Epub ahead of print]

Butany J, Luk A, Leong SW, Leong MM, Singh, Thangaroopan M, Williams W: A Carpentier- Edwards porcine-valved Dacron conduit: At twenty-five years. Int J Cardiol, 2007;117(1):e13-6.

Butany J, Nair V, Leong SW, Soor GS, Feindel C: Carpentier-Edwards perimount valves- morphological findings in surgical explants. J Cardiac Surg, 2007;22(1):7-12.

Chen CS, Wells PG: Enhanced tumorigenesis in p53 knockout mice exposed in utero to high- dose vitamin E. Carcinogenesis, 2006;27(7):1358-68.

Chen S, Lam TK, Park E, Burdett E,…Giacca A: Oleate-induced decrease in hepatocyte insulin binding is mediated by Protein Kinase C delta. Biochem Biophys Res Commun, 2006;346:931-7.

Cheng D, Diegeler A, Allen K, Weisel RD, et al: Transmyocardial laser revascularization: A meta-analysis and systematic review of controlled trials. Innovations, 2006;1:295-313.

Chiu K-L, Ryan CM, Shiota S,…Floras JS, Bradley TD: Fluid shift by lower body positive pressure increases pharyngeal resistance in healthy subjects. Am J Respir Crit Care Med, 2006;174:1378-83.

Choi J, Chiang A, Taulier N, Gros R, Pirani A, Husain M: A calmodulin-binding site on Cyclin E 2+ mediates Ca -sensitive G1/S transitions in vascular smooth muscle cells. Circ Res, 2006;98:1273-81, with accompanying Editorial: 1240-3.

Choi J, Husain M: Calmodulin-mediated cell cycle regulation: New mechanisms for old observations. Cell Cycle, 2006;5(19):2183-6. [Epub 2006 Oct 1]

Chong SA, Lee W, Arora PD, Laschinger C, Young EWK, Simmons CA, Manolson M, Sodek J, McCulloch CA: Methylglyoxal inhibits the binding step of collagen phagocytosis. J Biol Chem, 2007;282(11):8510-20.

37 Chukwuemeka A, Rao V, Armstrong S, Ivanov J, David T: Aortic valve replacement: A safe and durable option in patients with impaired left ventricular systolic function. Eur J Thor Cardiovasc Surg, 2006;29:133-8.

Chung MI, Miao M, Stahl RJ, Chan E, Parkinson J, Keeley FW: Sequences and domain structures of mammalian, avian, amphibian and teleost tropoelastins. Clues to the evolutionary history of elastins. Matrix Biol, 2006;25:492-504.

Costi S, Brooks D, Goldstein RS: Perspectives that influence action plans in COPD. Can Respir J, 2006;13:362-8.

Crowe J, Geddes EL, Brooks D, Reid WD: Use of inspiratory muscle training for patients with cervical spinal cord injury and chronic obstructive pulmonary disease: A survey of Canadian physiotherapy clinical practice. Physiother Can, 2006;58:271-9.

Cunningham KS, Veinot JP, Feindel CM, Butany J: Fatty lesions of the atria and interatrial septum. Hum Pathol, 2006;37(10):1245-51.

Dajnowiec D, Langille BL: Arterial adaptations to chronic changes in hemodynamic function: Coupling vasomotor tone to structural remodeling. Clinical Science, 2007;113:15-23.

Dajnowiec D, Sabatini PJB, Zhang M, Langille BL: Force-induced polarized mitosis of endothelial and smooth muscle cells in arterial remodeling. Hypertension, 2006;50:255-60.

Davierwala PM, Borger MA, David TE, Rao V, Maganti M, Yau TM: Reoperation is not an independent predictor of mortality during aortic valve surgery. J Thorac Cardiovasc Surg, 2006;131:329-35.

De Albuquerque N, Baig E, Ma X, Zhang J,…Butany J, Leibowitz J, et al: Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice. J Virol, 2006;80(21):10382-94.

De Albuquerque N, Baig E, Xuezhong M, Shalev I,…Butany J, Fish E, Levy G: Murine hepatitis virus strain 1 as a model for severe acute respirtory distress syndrome (SARS). Adv Exp Med Biol, 2006;581:373-8.

Desai N, Fremes SE: Intraoperative indocyanine green angiography: Ready for prime time? J Thorac Cardiovasc Surg, 2007;133(5):1396-7.

Desai ND, Miwa S, Kodama D, Cohen G,…Fremes SE: A randomized comparison of intraoperative indocyanine green angiography and transit-time flow measurement to detect technical errors in coronary bypass grafts. J Thorac Cardiovasc Surg, 2006;132(3):585-94.

Desai ND, Naylor CD, Kiss A, Cohen EA,…Fremes SE, for the Radial Study Patency Study Investigators: Impact of patient and target-vessel characteristics on arterial and venous bypass graft patency: Insight from a randomized trial. Circulation, 2007;115(6):684-91.

Dharmakumar R, Arumana JM, Larson AC, Chung Y, Wright GA, Li D: Cardiac phase-resolved blood oxygen-sensitive steady-state free precession MRI for evaluating the functional significance of coronary artery stenosis. Invest Radiol, 2007;42(3):180-8.

38 Diaz-Granados N, Stewart DE: Using a gender lens to monitor mental health. Int J Public Health, 2007;52:197-8.

Diegeler A, Cheng D, Allen K, Weisel RD, et al: Transmyocardial laser revascularization: A consensus statement of the International Society of Minimally Invasive Cardiothoracic Surgery (ISMICS) 2006. Innovations, 2006;1:314-22.

Dong-Sheng G, Wei-Yi F, Chiu-Man C, Kirsh J, Gross G, Hamilton RM: QT hysteresis in long- QT syndrome children with exercise testing. Chinese Med J, 2007;120:179-82.

Dorian P: The future of atrial fibrillation therapy. J Cardiovasc Electrophysiol, 2006;17(Suppl 2):S11-6.

Duca L, Blanchevoye C, Cantarelli B,…Hinek A, Martiny L, Debelle L: The elastin receptor complex transduces signals through the catalytic activity of its Neu-1 sub-unit. J Biol Chem, 2007;282(17):12484-91.

Erlich I, Strauss BH, Butany J: Stent thrombosis following the STAR technique in a complex RCA chronic total occlusion. Catheter Cardiovasc Interv, 2006;68(5):708-12.

Faber P, Reid C, El-Shafei H, Falase B, DeAnda Jr A, Mazer CD: Recombinant factor VIIa in the management of postoperative bleeding after repair for inadvertently thrombolysed acute type A aortic dissection. J Cardiothorac Vasc Anesth, 2006;20(5):736-41.

Fawcell AP, Cunic D, Hamani C, Hodaie M, Lozano AM, Chen R, Hutchison WD: Saccade- related potentials recorded from human subthalamic nucleus. Clin Neurophysiol, 2006;118:155- 63.

Fazel S, Cimini M, Chen L, Li S-H,…Weisel RD, Keating A, Li R-K: Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest, 2006;116(7):1865-77.

Fitchett DH, Borgundvaag B, Cantor W, Cohen E, Dhingra S, Fremes S,…Husain M, Langer A, Letovsky E, Goodman SG: Non ST segment elevation acute coronary syndromes: A simplified risk-orientated algorithm. Can J Cardiol, 2006;22(8):663-77.

Fitzmaurice P, Tong J, Yazdanpanah M, Liu PP, Kalasinsky KS, Kish SJ: Levels of 4- hydroynonenal and malondialdehyde are increased in brain of human chronic users of methamphentaminel. J Pharmacol Exp Ther, 2006;319:703-9. [Epub 2006 Jul 20]

Flaman F, Zieroth S, Rao V, Ross JH, Delgado DH: Basiliximab versus rabbit anti-thymocyte globulin for induction therapy in patients post heart transplantation. J Heart Lung Transplant, 2006;25:1358-62.

Foltz WD, Yang Y, Graham JJ, Detsky JS, Wright GA, Dick AJ: MRI relaxation fluctuations in acute reperfused hemorrhagic infarction. Magn Reson Med, 2006;56(6):1311-9.

Franco C, Ho B, Mulholland D, Hou G, Islam M, Rayner K, Bendeck MP: Doxycycline alters vascular smooth muscle cell adhesion, migration and reorganization of fibrillar collagen matrices in vitro. Am J Pathol, 2006;168:1697-1709.

39 Freed LE, Guilak F, Gui XE, Gray ML,…Sefton MV, Kaplan D, Vunjak-Novakovic G: Advanced tools for tissue engineering: Scaffolds, bioreactors, and signaling. Tissue Eng, 2006;12:3285- 305.

Frier BC, Locke M: Heat stress inhibits skeletal muscle hypertrophy. Cell Stree Chaperones, 2007;12:132-41.

Gagnon AJ, Dougherty G, Platt RW,…Stewart DE: Refugee and refugee-claimant women and infants post-birth: Migration histories as a predictor of Canadian health system response to needs. Can J Public Health, 2007;98:287-91.

Gagnon AJ, Wahoush O, Dougherty G, Saucier JF, Dennis CL, Merry L, Stanger E, Stewart DE: The childbearing health and related service needs of newcomers (CHARSNN) study protocol. BMC Pregnancy Childbirth, 2006;6:31.

Gilmore ED, Hudson C, Nrusimhadevara RK, Harvey PT, Mandelcorn M, Lam WC, Devenyi RG: Retinal arteriolar diameter, blood velocity and blood flow response to an isocapnic hyperoxic provocation in early sight-threatening diabetic retinopathy. Invest Ophthalmol Vis Sci, 2007;48:1744-50.

Gilmore Ed, Hudson C, Nrusimhadevara RK, Ridout R, Harvey PT, Mandelcorn M, Lam WC, Devenyi RG: Retinal arteriolar haemodynamic response to an acute hyperglycaemic provocation in early and sight-threatening diabetic retinopathy. Microvasc Res, 2007;73:191-7.

Goh TT, Mason TM, Gupta N, So A, Lam TK, Lam L, Lewis GF, Mari A, Giacca A: Lipid- induced beta cell dysfunction in vivo in models of progressive beta cell failure. Am J Physiol Endocrinol Metab, 2007;292:E549-60.

Grace SL, Barry-Bianchi S, Stewart DE, Rukholm E, Nolan RP: Physical activity behavior, motivational readiness and self-efficacy among Ontarians with cardiovascular disease and diabetes. J Behav Med, 2007;30:21-9.

Grace SL, Scholey P, Suskin N, Arthur H, Brooks D, Jaglal S, Abramson BL, Stewart DE: A prospective comparison of cardiac rehabilitation enrolment following automatic versus usual referral. J Rehabil Med, 2007;39(3):239-45.

Grace SL, Williams A, Stewart DE, Franche R-L: Health-promoting behaviours through pregnancy, maternity leave, and return to work: Effects of role spillover and other correlates. Women Health, 2006;43:51-72.

Gramolini AO, Kislinger T, Liu PP, MacLennan DH, Emili A: Analyzing the cardiac muscle proteome by liquid chromatography-mass spectrometry (LC-MS) based expression proteomics. Method Mol Biol, 2007;357:15-32.

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