Faculty of Medicine s2

Faculty of Medicine

Senior Lecturer in Infectious Diseases

Honorary Consultant in Infectious Diseases, University Hospital Southampton NHS Foundation Trust

Particulars of Appointment The Faculty of Medicine, supported by University Hospital Southampton NHS Foundation Trust (UHS) wishes to appoint a Senior Lecturer in Infectious Diseases. This academic post will function within the Clinical and Experimental Sciences Academic Unit on the General Hospital campus. The successful candidate will have a strong record of research and publication, and will be expected to develop their own programme of research with support from clinical and laboratory-based colleagues, winning support from major national funding bodies. It is expected that the person appointed will contribute to the academic leadership within the Faculty and enhance the quality of our research, enterprise and teaching. Clinical duties will enhance the existing practice of the Department of Infection in University Hospital Southampton NHS Foundation Trust.

The University The University of Southampton is a leading research-intensive University, a member of the Russell Group and one of the top 100 universities worldwide. We deliver an excellent educational experience, world-leading research and we are known for successfully commercialising that research through enterprise.

This is an exciting time to join the University of Southampton. We have an aspirational University Strategy (see www.southampton.ac.uk/strategy), setting out our ambitions over the next five years. The strategy involves achieving a top 10 place in the UK for research, which we will achieve by investing in the highest quality staff and facilities. We are also transforming the education offer available to undergraduate and postgraduate students across the University, providing greater flexibility and modular courses, with a strong international focus.

The Faculty of Medicine The creation of the Faculty of Medicine has enabled us to build upon strong foundations of basic research and clinical translation. Working with colleagues across the University and in the local NHS we have strengthened our position as a renowned centre for translational research, leading innovative learning and discovery for better health across the lifecourse. In this context, we are looking to appoint an outstanding senior academic to develop and lead a major programme of funded clinical research in the field of Infectious Diseases.

Key to the success of the Faculty of Medicine is the delivery of high-quality education for undergraduate and postgraduate students, building on our partnership in biomedical research with University Hospital Southampton NHS Foundation Trust and fostering new collaborations with the physical sciences, including chemistry, engineering and computing. The new senior academic in Infectious Diseases will play a key role in these developments.

Medical Education We offer a range of undergraduate programmes: the BM4 programme, a graduate-entry four-year programme which accepts 40 students per year; and the BM5and BMedSc programme which accepts 200 students per year including approximately 30 students from a BM6 programme aimed at widening access to a medical career. Science teaching in the first three years of the BM programmes is delivered in the South Block of Southampton General Hospital as well as the Life Sciences Building on Highfield Campus. Clinical teaching takes place at Southampton General Hospital and the adjoining Princess Anne Hospital, the Royal South Hants Hospital, and in NHS Trusts and General Practices throughout Hampshire, Dorset, West Sussex and Salisbury.

The BM5 programme has a number of distinctive features. These include the integrated nature of teaching where the scientific disciplines are taught together in a clinical context using a systems based approach and the BMedSc programme, an eight month supervised research project undertaken in Year 4. There is also the opportunity, for selected students, to undertake an integrated, intercalated Masters in Medical Science (MMedSc). The BM4 programme also has a number of key features. These include clinical topics in the first two years where students meet on a regular basis in Graduate Groups, and learning with BM5 students in the third and fourth years on all clinical attachments. All students take the same intermediate and final examinations. All programmes have substantial clinical experience in the first two years, student selected components, dispersed final year attachments, work shadowing prior to commencing a Foundation post and inter-professional learning.

In addition to the undergraduate BM programmes the School provides two Masters Degree programmes in Public Health and Allergy.

Research and Enterprise The Faculty of Medicine has a clear research strategy to investigate the biomedical basis of common human diseases and to translate this into clinical practice. The Faculty’s research is delivered through four Academic Units:  Cancer Sciences  Clinical and Experimental Sciences  Human Development and Health  Primary Care and Population Sciences

All research is organised and managed by these Academic Units, each of which has clear evidence of international excellence. Each carries a significant degree of devolved responsibility for its research budgets and grants, space, equipment and personnel.

The Faculty of Medicine Enterprise Strategy is fully embedded with the University Enterprise Strategy with a multi-faceted strategy to provide a step change to its enterprise and innovation culture, delivering global outreach, community engagement, innovative healthcare and policy. We work with all stakeholders from industry and pharma to health providers and the community.

Working in close partnership with University Hospital Southampton NHS Foundation Trust, translational research is delivered through the Southampton Centre for Biomedical Research, bringing together the Wellcome Trust Clinical Research Facility, the Clinical Trials Unit, NIHR Biomedical Research Centre in Nutrition Lifestyle, NIHR Biomedical Research Units in Respiratory Medicine, shadow Biomedical Research Units in Cardiovascular, and Bone and Joint Disease, and the Cancer Research UK, Experimental Cancer Medicine Centre.

2 Clinical and Experimental Sciences (CES) Academic Unit The Academic Unit is based within the South Laboratory & Pathology Block of Southampton General Hospital. The building (5 floors) has undergone a £10.5 million refurbishment funded by the Wellcome Trust and the Scientific Research Infrastructure Fund (SRIF). There are currently 53 principle investigators and an additional 34 research staff, mostly grant funded (MRC, BBSRC, Wellcome Trust, NIH, National Asthma Campaign and other organisations). The research interests form a 2-dimentional lattice in which process-orientated studies of infection, immunity, allergy inflammation, fibrosis and repair are pursued in organ-based settings of lung, liver skin and gut. These are best appreciated by visiting the web site (http://www.southampton.ac.uk/medicine/academic_units/academic_units/clinical_experimental_sciences.page?) where the senior investigators, group interests, recent publications and other links are presented and frequently updated. Core facilities include a FACS suite, biomedical imaging unit, histochemistry unit, Category III containment facility and one of only 5 Wellcome Trust Clinical Research facilities. There is equipment to match this research, an efficient infrastructure of administrative staff and good management integration within the Academic Unit and between Academic Unit and Faculty of Medicine.

The Molecular Microbiology group sits within this Academic Unit and currently comprises of 5 members of academic staff: clinical Professor (R Read); non-clinical Professor (I. Clarke), Reader (S.Clarke), Senior Lecturer (Christodoulides) and Lecturer (McCormick). Basic research within the University Molecular Microbiology group is focused on the study of host - parasite relationships and the interaction, at the molecular level, between infectious agents and their target cells. The research follows several complementary themes: "molecular genetics" where the emphasis is on the development of molecular systems for the manipulation of viral and bacterial genomes, the "pathogenesis of infectious diseases" and vaccine development/disease prevention strategies. There is expertise in infection proteomics, epidemiology, molecular diagnostics, public health, primary care, environmental microbiology, biofilms and studies of host-pathogen relationships. There are internationally-recognised groups in noroviruses, hepatitis C virus, chlamydia, gonococci, meningococcal and pneumococcal infections and MRSA (all at the forefront of the health agenda) with expertise in epidemiology, molecular diagnostics, public health, primary care. There are excellent opportunities for collaboration and translational research through sharing of clinical data and samples and staff expertise.

There are significant cross faculty collaborations forged by members of the Academic Unit, including areas of proteomics, stem cell and developmental biology, bioengineering and electronics. Such collaborations are strongly encouraged by the University and the successful candidate will be well placed to exploit similar opportunities.

CES Academic Staff Dr Aminul Ahmed Clinical Lecturer in Neurosurgery Dr Michael Ardern-Jones Senior Lecturer in Dermatology Prof S Hasan Arshad Prof In Allergy & Clinical Immunology Prof David Baldwin Professor in Psychiatry Dr Delphine Boche Senior Lecturer Dr Roxana Carare Senior Lecturer Dr Myron Christodoulides Senior Lecturer Prof Howard Clark Professor of Child Health Prof Ian Clarke Professor in Molecular Microbiology Dr Stuart Clarke Reader Dr Jane Collins Senior Lecturer Prof Donna Davies Professor in Resp, Cell & Molecular Biology Prof Ratko Djukanovic Professor of Medicine Dr Paul Elkington Senior Lecturer in Respiratory Medicine Dr Saul Faust Senior Lecturer in Child Health & Director WTCRF Prof Martin Feelisch Professor of Experimental Medicine & Integrative Biology Dr Ian Galea Clinical Lecturer in Neurology Dr Kevin Goss Clinical Lecturer in Child Health Dr Srini Goverdhan Senior Lecturer in Ophthalmology Prof Michael Grocott Professor of Anaesthesia & Critical Care Dr Hans Michael Haitchi Senior Lecturer in Respiratory Medicine Prof Eugene Healy Professor of Dermatology Dr Catherine Hill Senior Lecturer in Community Child Health Dr Timothy Hinks Clinical Lecturer in Respiratory Medicine Prof Stephen Holgate Professor of Immunopharmacology Dr Judith Holloway Senior Lecturer In Allergy Prof Clive Holmes Professor in Biological Psychiatry Mr Parwez Hossain Senior Lecturer in Ophthalmology Prof Peter Howarth Professor of Allergy & Respiratory Medicine Prof Colin Kennedy Professor in Neurology & Paediatrics Prof Salim Khakoo Professor of Hepatololgy Prof David Kingdon Professor of Mental Health Care Delivery Dr Peter Lackie Lecturer Prof Andrew Lotery Professor of Ophthalmology Dr Jane Lucas Clinical Senior Lecturer Dr Jens Madsen Lecturer Dr Christopher McCormick Lecturer in Immunology Dr Timothy Millar Lecturer in Pharmacology Dr Tracey Newman Lecturer Prof James Nicoll Professor of Neuropathology Dr Sylvia Pender Reader in Mucosal Biology Prof Robert Peveler Professor of Liason Psychiatry Dr Katharine Pike Clinical Lecturer in Respiratory Paediatric Prof Anthony Postle Professor in Developmental Biochemistry Dr Ashley Pringle Senior Lecturer Dr Arjuna Ratnayaka Lecturer in Vision Sciences Prof Robert Read Professor of Infectious Diseases Prof William Roche Professor of Pathology Mr Rami Salib Clinical Senior Lecturer Dr Anthony Sampson Reader Dr Tilman Sanchez-Elsner Senior Lecturer in Biomedical Sciences Dr Nicholas Sheron Clinical Senior Lecturer Dr Julia Sinclair Clinical Senior Lecturer in Psychiatry Dr Emily Swindle Lecturer in Pharmacology Dr Marc Tebruegge Clinical Lecturer in Child Health Dr Brigitte Vollmer Senior Lecturer in Paediatric Neurology Dr Andrew Walls Reader Dr Jane Warner Senior Lecturer Dr Thomas Wilkinson Reader in Respiratory Medicine Dr Sandrine Willaime-Morawek Lecturer (Stem Cells/Brain Repair) Dr Susan Wilson Senior Lecturer Dr Anthony Wiskin Clinical Lecturer in Child Health

4 Relationships with the National Health Service

University Hospital Southampton NHS Foundation Trust (UHS) The Trust provides acute healthcare services for Southampton area (population 550,000). This covers an area bordering on the Solent and extending to the boundary of Winchester in the north, the Wiltshire border in the west and the River Hamble in the east. In addition, many specialist services are provided to a much wider area extending to Chichester, Portsmouth, Winchester, Basingstoke, Salisbury, Bournemouth and Poole, Dorchester, the Isle of Wight and the Channel Islands. These include the defining services of the Trust in cancer, neurosciences, respiratory, gastrointestinal, women and children and cardiothoracic. Southampton forms one of the two teaching hospitals in the South Central Health Authority Region and, as a Calman-Hine Regional Cancer Centre, provides comprehensive cancer services for a large population of 3+ million.

Southampton General Hospital (SGH) has 1,200 beds and Princess Anne Hospital (PAH), part of the same Trust, has 124 beds.

UHS – Department of Infection

Clinical Services The Department of Infection currently operates an infectious diseases service with 8 consultants (5 Medical Microbiology, 1 Virology, 2 Medical Microbiology/Infectious Diseases). A clinical Professor of Infectious Diseases has been appointed (Professor Read) and the service is currently being gradually expanded to create an inpatient infectious disease service. Hitherto, the department has developed strengths in antimicrobial stewardship, clinical infection liaison across all care groups and management and prevention of healthcare associated infection. The Department of Infection is closely integrated with all clinical care groups and consultants lead infection services to individual areas by agreement. Considerable infection liaison takes place at ward level and consultants give advice and accept consults on all aspects of infection management. A central activity is leading a highly successful system of combined infection and pharmacy ward-rounds, which occur in all care groups. All consultants, whether employed by UHS, the Health Protection Agency (HPA) or University, are expected to work together as a team in providing the clinical service which is headed by the UHS Clinical Lead. Since October 2010, the Department of Infection has adopted a consultant led and delivered service model.

Further development of the out-patient parenteral antibiotic (OPAT) service is regarded as important for UHS in order to release bed days and improve patient experience. UHS also wishes to develop further its clinical infection service to include admission of infectious diseases patients under sole or joint care of infection consultants. Further clinical developments of the service will be inclusive of all consultant staff, ensuring the skills of all consultants can be used to the full to the benefit of patient care whilst maintaining cohesiveness of the department under single leadership.

Infection Prevention and Control UHS has identified Infection Prevention as a priority. Statistical feedback control chart monitoring of MRSA and Clostridium difficile infection has been used for some time by the Infection Prevention Team to feed back performance to divisions. Laboratory data-warehousing advances now enable sophisticated analysis of hospital-acquired infection issues at ward, care group and divisional level. Feedback of this analysis encourages ownership of HCAI issues, rapidly identifies hotspots and facilitates a co-ordinated response combining targeted infection control antimicrobial control support.

The Infection Prevention Team comprises the Infection Control Doctor (also known as the Director of the Infection Prevention Unit), Lead Infection Prevention Nurse and a number of ICNS, supported by administration staff.

The Infection Control Doctor (ICD) is accountable to the Director of Infection Prevention and Control (DIPC), who is the Director of Nursing (Judy Gillow), for their infection prevention work. The Lead Nurse reports to the Infection Control Doctor. The ICD is appointed by the DIPC. The ICD will review their position with the DIPC 3 years into appointment and annually thereafter, at which point the post will be subject to revalidation, or if agreed, offered for application by other infection consultants.

Infection prevention and control service provision in the community is provided by separate Community Infection Control teams.

Diagnostic Services Pathology sits within Division D (Cardiovascular and thoracic, Neurosciences, Radiology and pathology, Trauma and orthopaedics). Currently, all diagnostic microbiology laboratory services are provided to UHS, local PCTs and GPs by the HPA (PHE) on a contract basis. Arrangements for provision of diagnostic microbiology services are in the process of being reviewed as part of the Pathology Modernisation Programme. A pathology consortium has been formed between the six main Trusts and providers in the region (Southampton, HPA, Portsmouth, Winchester, Isle of Wight and Basingstoke) to manage the future service.

The current management arrangements are consistent with the recommendation of the Strategic Review of Pathology Services (1994), notably paragraphs 4.22-4.26

The Southampton HPA Laboratory is accredited by CPA. Workload for 2010-11 was 610,000 specimens with approximately 30% from General Practice. Bacteriology work comprises 386,000 specimens of which 25,000 are blood cultures, 5,200 tissues and fluids and 3,600 CSFs. Virological/serological examinations comprise 191,000 specimens and the laboratory performs 30,000 in house molecular diagnostic assays. The laboratory also performs some 42,000 Chlamydia NAATS tests.

The laboratory budget is approximately £3 million and is currently managed by the HPA Clinical Services Lead with input from the UHS Clinical Lead.

A full range of diagnostic microbiological services is provided including bacteriology, mycobacteriology, virology, mycology and parasitology. The laboratory is highly automated and fully interfaced with the pathology computer system. The molecular diagnostic service is housed in a purpose-built suite of rooms, and offers a wide range of diagnostic services, with further assays under development.

As the South East Regional HPA Laboratory, Southampton currently provides diagnostic services for a range of public health microbiology including regional influenza molecular diagnostics and food and environmental microbiology.

Wessex Medical Microbiology Training Scheme Southampton is one of the training centres for the Wessex STR scheme and from August 2013 will host joint trainees in Infectious Disease and Medical Microbiology in collaboration with Portsmouth and Basingstoke/Winchester. In addition one ID/General Internal Medicine NTN has been created and is shared by Southampton with Oxford. As for all other consultant staff, the post-holder will be responsible for the training and clinical supervision of junior medical staff who work with him/her and will devote time to this activity on a regular basis. Wessex will adopt the proposed core infection training curriculum and the post-holder would contribute to introduction and clinical supervision of the scheme in UHS, working in collaboration with the Department of Infection Educational Supervisor. The post-holder would also be encouraged to develop training schemes for clinical academic posts.

Professional Relationships The successful candidate will be expected to work in liaison with:

 The UHS Clinical Lead for their NHS commitments, the HPA Laboratory Clinical Services Lead, the Infection Control Doctor, other senior staff including Consultant Infectious Disease Physicians and Microbiologists, Consultant Virologist, Clinical Scientists, BMS staff, the CCDC, and the Director of Public Health.  consultant clinicians and their junior staff at UHS  general practitioners in the catchment area of the Southampton Laboratory.

6  Health Protection Units within the catchment of the SE Regional HPA laboratory (the local HPU is based in Whiteley).  the Infection Control Nurses and DIPC  the Chief Executive and other senior staff of UHS, and other Trusts serviced by the laboratories and clinical infection service  senior nursing, paramedical and administrative staff in the above Trusts  members of UHS / University of Southampton School of Medicine with responsibility for postgraduate / undergraduate medical education  Consultant pharmacist and clinical pharmacists

Governance It is expected that the post holder will actively contribute to Trust clinical governance activities, participate in Continuing Professional Development (CPD) and audit of their clinical and the Department of Infection’s activity, and participate in departmental Morbidity Mortality meetings. Time and facilities will be available for CPD and audit.

Management Structure Southampton General Hospital established a Clinical Management System in 1986, which was extended throughout Southampton University Hospitals in 1991. This system was changed in 2005 to a Divisional structure. Its continuation is a matter of paramount importance and it will be carefully developed and enhanced to meet the needs of the Trust as a major provider. All consultants and clinical care providers come within the Divisional system, and are expected to participate in the medical contribution to management.

All medical/academic staff contributing to the clinical infection service are accountable to the UHS Clinical Lead for their clinical work. The UHS Clinical Lead is accountable to the Divisional Clinical Director (DCD). The DCD has overall responsibility for the services within the Division and is responsible for the UHS clinical services budget. Laboratory resource/service provision issues are currently managed by the HPA Clinical Services Lead. The ICD and Deputy ICD are accountable to the DIPC for their infection prevention work.

The UHS Clinical Lead sits on the HPA Microbiology Laboratory Management Group to ensure HPA accountability for laboratory service delivery to UHS. The local commissioning group ensures discussion of day-to-day and local expectations of laboratory service delivery to infection consultants and the infection prevention team and UHS, as well as setting clinical priorities. This group is attended by the HPA Clinical Services Lead, the UHS Clinical Lead, Senior BMSs in virology + bacteriology and the ICD.

Department of Infection NHS/HPA staff Consultants Dr A Basarab (UHS Consultant in Infection) Dr G Jones (UHS Consultant in Infection, Infection Control Doctor) Dr A Pallett (UHS Consultant in Infection, Pathology Education Lead) Dr T Yam (UHS Clinical Lead, Consultant in Infection, Deputy Infection Control Doctor) Dr J Sutton (Consultant in Infection) Dr E Pelosi (HPA Consultant Virology) Dr H Schuster (HPA Consultant in Infection) Dr Sarah Glover (UHS Consultant in Infection) Professor Robert Read (University Professor, and Hon Consultant Physician) Trainee Medical Staff - 2-3 ID/Medical Microbiology STRs, 1 ID/GIM STR

General Provisions Southampton University Hospitals NHS Trust expects all medical and dental staff to work within the guidelines of the “General Medical Council Guide - Good Medical Practice”. Subject to the provisions of the Terms and Conditions of Service, the post-holder will be expected to observe the Trust's agreed policies and procedures, drawn up in consultation with the profession on clinical matters, and to follow the standing orders and financial instructions of the Trust.

In particular, where the post-holder manages employees of the Trust, he/she will be expected to follow the local and national employment and personnel policies and procedures. The post-holder will be expected to make sure that there are adequate arrangements for hospital staff involved in the care of his/her patients to be able to contact him/her when necessary.

All medical and dental staff employed by the Trust or providing clinical care in the Trust are expected to comply with its Health and Safety Policy and procedures and mandatory training requirements.

Job Planning and Appraisal It is recognised that the clinical work programme will take time to settle into a regular pattern. Therefore the 5 PA work programme will be reviewed in discussion with the UHS Department of Infection Clinical Lead after 3 months and annually thereafter. Currently no funding is available for on-call activity. The appointee will be appraised annually jointly with the University of Southampton.

2.25 PA Ward Work 1.5 PA Infectious diseases clinic 1.25 PA SPA

Other Duties From time to time it may be necessary for the post-holder to carry out such other duties as may be assigned, with agreement, by the Trust. It is expected that the post-holder will not unreasonably withhold agreement to any proposed changes.

8 Terms of Appointment

1. The appointment will be governed by the general conditions applicable to clinical academic staff in the University of Southampton; details of these are available on request and will be sent to candidates called for interview. The appointee will be subject to the relevant terms of appointment as determined by the appropriate NHS Trust, in connection with his/her clinical duties in so far as they may apply to clinical academic staff holding honorary NHS Trust contracts. The appointee will be responsible to the Dean of the Faculty of Medicine through the Head of Academic Unit for the satisfactory conduct of his/her duties.

2. The successful candidate will be expected to take up their appointment as soon as possible. The appointment may be subject to a probationary period of up to three years.

3. The appointment will be made within the Clinical Academic (Honorary Consultant) salary scale), depending on qualifications and experience.

4. The appointment may be terminated by a semester’s notice on either side.

5. In addition to your substantive contract of employment with the University, you will also hold an honorary NHS contract with Southampton University Hospitals NHS Trust and are required to be registered with the General Medical Council. This honorary contract and registration is essential for the proper performance of the duties of your employment with the University. In the event that the honorary contract is terminated or the registration is revoked or suspended, your continued employment with the University under this contract will need to be reviewed and may be terminated. The procedure for considering whether to terminate your substantive contract of employment with the University in such circumstances is set out in the University’s Statutes and Ordinances from time to time in force and in a protocol between the University and the NHS Trust. You will be required during your tenure of office to undertake appropriate clinical work on an honorary basis under the National Health Service. No professional contact with National Health Service patients may be undertaken unless a duly authorised honorary contract has been issued to you and is currently valid.

6. The appointee will be subject to joint annual appraisal between the University and the relevant NHS Trust.

7. The person appointed will be required to observe the Charter, Statutes and Ordinances of the University and to carry out all orders and regulations of the Council. It should be noted that these regulations include a policy of no smoking at work which, with the exception of certain designated areas, prohibits smoking in most University buildings.

8. The person appointed will be expected to work within the spirit and letter of the University's Equal Opportunities Policy: "The University of Southampton confirms its commitment to a comprehensive policy of equal opportunities in employment and for students in which individuals are selected and treated on the basis of their relevant merits and abilities and are given equal opportunities within the University. The aim of the policy is to ensure that no job applicant or employee, prospective student or student, should receive less favourable treatment on any grounds which are not relevant to good employment practice for staff or to academic ability and attainment for students. The University is committed to a programme of action to make the policy fully effective."

Because of the nature of the work for which you are applying, this post is exempt from the provisions of Section 4(2) of the Rehabilitation of Offenders Act 1974 by virtue of the Rehabilitation of Offenders Act 1974 (Exceptions) Order 1975. Applicants are, therefore, not entitled to withhold information about convictions and, in the event of employment, any failure to disclose such convictions could result in dismissal or disciplinary action by the University. The University will routinely conduct checks on criminal records for all those appointed to posts that have contact with children or vulnerable adults. Any information given will be completely confidential and will be considered only in relation to an application for positions to which the order is applied. 10