DRAFT Programme Translational Imaging Workshop by AMIE ‘From mouse to man’

1st draft vs 161102, subject to change!

Tuesday 11, Wednesday 12, Thursday 13 and Friday 14 April, 2017 (Friday 14 long practicals)

The programme Applied Molecular Imaging at Erasmus MC (AMIE) provides a platform for scientists interested in imaging technology and molecular imaging in general.

The aim of this 4-day workshop is to give a broad introduction into preclinical and translational Molecular Imaging techniques and their applications in biology and medicine. This workshop is designed for PhD students and researchers in one of the Erasmus Postgraduate Schools; PhD students and researchers from other universities are also welcome. This workshop is being organized for the 9th time, following upon eight very successful workshops from 2008 till 2014.

The speakers from the Erasmus MC, the Leiden University Medical Centre (LUMC) and the Technical University Delft (TU Delft) have great expertise in animal and molecular imaging. The workshop will cover a wide array of imaging technologies, including:

 Optical imaging  X-Ray Computed Tomography (CT)  Magnetic resonance imaging (MRI)  (Multimodality) Radionuclide imaging: PET and SPECT  Photo Acoustics  Ultrasound imaging  Hyperpolarized MRI  Photo dynamic diagnostics and therapy (PDT)  Image Analysis  Clinical applications

Several applications in translational research will be discussed, such as multi-modality detection, imaging of cancer, and imaging of vascular diseases. In addition to the lectures presented in the programme, practical demonstrations on the different imaging devices will be given in the newly realized Animal Imaging Facility, the AMIE Facility, designed to facilitate multi-modal animal imaging. SPECT/CT (U-SPECT/CT, NanoSPECT/CT), PET (Inveon), CT (Skyscan), optical (ICIS), and MRI (7T GE/Varian) imaging equipment are housed in a single complex.

On Friday, we offer the opportunity to the participants to do a long practical session during a full day. Limited admittance: first come, first serve.

The total number of participants in the course is limited to 70; the total number of participants in the demonstrations, lab visits and practical sessions on Friday is limited to 40. The latter are based on ‘first come, first serve’. Tuition is €550 (including coffee, tea and lunches and a drink); however, most participants are expected to qualify for a (partial) scholarship. See the last page for details.

1 The workshop counts for 1,25 ECTS credit points, including all lab visits, practical sessions and self study; 1,00 ECTS without the practical session on Friday.

The location of the workshop is room Ae 4.06 (Erasmus MC). All lunches, coffee, tea and a drink are included. Registration via the Website of MolMed: www.molmed.nl.

If you have any questions, please contact Frank van Vliet: +31 (0)10 704 3518 or + 31 (0)6 5474 6408 or Joris Lenstra: +31 (0)10 703 8053 / [email protected].

The organizing committee,

Monique Bernsen Jeroen Essers Joost Haeck Marion de Jong Klazina Kooiman Clemens Löwik Frank van Vliet

The organizers wish to thank the following for their invaluable contributions to this workshop:

2 Tuesday April 11th; room Ae 4.06 Time Speaker Title Key words 09:00-09:30 Registration Moderator: Marion de Jong, Dept. of Nuclear Medicine, Erasmus MC 09:30-09:45 Marion de Jong, Welcome and short Applied Molecular Imaging at the Dept. of Nuclear introduction to the Erasmus MC (AMIE) Medicine&Radiology, Translational Imaging Erasmus MC Workshop 09:45-10:30 Martje Fentener, Animal facilities and animal Applications Dept. Animal imaging; animal models Facility Erasmus MC (EDC) 10:30-10:45 Coffee break NB combined with Bridge meeting 11.00-12.00 hr 10:45-11:30 Louise van der Introduction to MRI Physics & instrumentation; Ultra- Weerd, LUMC high field MRI, high resolution, phenotyping, contrast at high field, anatomy & functionality, molecular imaging 11:30-12:15 Piotr Wielopolski, MRI Applications: neurological (AD), Dept. of Radiology, cardiac (MI, atherosclerosis) Erasmus MC 12:15-13:15 Lunch break 12:30-13:15 Short visits to the CAVE (3-D) in 3 groups (A. Koning, via corridor Ee 15.28-15.42) Moderator: Monique Bernsen, Dept. of Dept. of Radiology, Erasmus MC 13:15-14:00 Hans Bosch, Ultrasound imaging Tutorial: Physics, instrumentation, Biomedical Engi- and applications neering, Cardiology, Erasmus MC 14:00-14:45 Rory de Zanger, Radiochemistry Tutorial: Tracer, labeling, Dept. of Nuclear cyclotron, generator Medicine, Erasmus 14:45-15:00 Coffee break 15:00-15:45 Marlies Goorden, PET & SPECT imaging Tutorial: Instrumentation TU Delft 15:45-16:30 Joost Haeck, Dept. (Multimodal) PET imaging, Tutorial: Physics and of Nuclear Medicine combined with MRI & CT, instrumentation, radionuclides, & Radiology, optical, SPECT tracer Erasmus MC 16:30-17:15 Erwin Waarsing, X-Ray CT: Computed Tutorial: physics, instrumentation, Dept. of Orthope- Tomography and applications dics, Erasmus MC 17:15-… Welcome drinks for all participants and speakers, offered by the Postgraduate School Molecular Medicine

Wednesday April 12th; room Ae 4.06 Time Speaker Title Key words Moderator: Jeroen Essers, Depts. of Cell Biology & Genetics and Radiotherapy, Erasmus MC 09:15-10.00 Monique Bernsen, Probes for molecular Applications: equipment, probes Dept. of Radiology imaging; multi-modality and applications, pitfalls and & Nuclear Medicine, future outlook Erasmus MC 10:00-10:45 Dominic Robinson, Optical Diagnostics and Applications: Physics, Optical CODT, Erasmus MC Photodynamic Therapy Spectroscopy, Imaging, Light Therapy, Instrumentation and Applications

3 10:45-11:00 Coffee break 11:00-12:15 Clemens Löwik Can we cure cancer? Applications: Fluorescence Image New approaches and Guided Surgery(FIGS); imaging tools Combination Therapy with Immuno Therapie; transgene mouse models 12:15-13:15 Lunch break 12:15-13:15 ‘Meet the professor’ lunch with …? T.b.d. Moderator: Klazina Kooiman, Dept. of Biomedical Engineering/ Cardiology, Erasmus MC 13:15-14:00 Nynke van den Probes: Hybrid imaging Applications: surgical guidance, Berg, LUMC agents for interventional sentinel node, SPECT, molecular imaging, a fluorescence, targeted peptides, clinical story multimodal 14:00-14:45 Klazina Kooiman, Contrast enhanced Tutorial: Physics, instrumentation, Biomedical Eng., ultrasound imaging and applications Cardiology,Erasmus MC 14:45-15:00 Coffee break 15:00-15:45 Jeroen Essers, MicroCT-optical imaging Multimodal bioluminescence-CT Depts. of Cell and fluorescence-CT imaging, Biology & Genetics microCT for functional imaging and Radiotherapy, Erasmus MC 15:45-15:55 Walk to demos 15:55-17:35 Coordination: Demonstrations; lab visit 5 topics, 4 groups, each group Joost Haeck/Yanto (sessions 1 & 2 of 50’ about 6 participants (name, room Ridwan, Depts. of each); schedule see nr.): Nuclear Medicine/ below  MRI (M. Bernsen, J. Haeck; Cell Biology & AMIE Facility, CE building) Genetics and  CT (Erwin Waarsing, AMIE Radiotherapy Facility, CE building)  SPECT/PET (M. de Jong, J. de Swart, AMIE Facility, CE building)  Ultrasound (Klazina Kooiman; room Ee 23.29 & Ee 23.16)  Optical Imaging/Ivis 200 (Jeroen Essers, Yanto Ridwan, room Ce050) Session 1 15:55 – 16:45 Group1 CT (no Ultrasound) Group2 SPECT-PET Group3 Optical Imaging Group4 MRI

Session 2 16:45 – 17:35 Group1 MRI (no Optical) Group2 CT Group3 SPECT-PET Group4 Ultrasound

4 Thursday, April 13th; room Ae 4.06 Moderator: Clemens Löwik, Dept. of Dept. of Radiology, Erasmus MC Time Speaker Title Introduction or application; Key words 09:15-10:00 Timo ten Hagen, Intravital Imaging; Applications: intravital Surgical Oncology, targeted nanocarriers for microscopy, cancer, confocal, Erasmus MC imaging and therapy intratumoral, in vivo intracellular; multifunctional lipid-nanocarriers, targeted nanomedicine, image- guided drug delivery, cancer, inflammation 10:00-10:45 Erik Meijering, Image Analysis Applications: Quantitative image Biomedical Imaging analysis; Multimodal image group Rotterdam, analysis; Image registration, Depts. of Radiology & fusion, and visualization Medical Informatics, Erasmus MC 10:45-11:00 Coffee break 11:00-11:45 Gijs van Soest, Dept. Physics of photoacoustic Acoustic vs. optical resolution, of Biomedical imaging endogenous vs. exogenous Engineering/ Cardi- contrast, microvessels and flow, ology, Erasmus MC oxygen saturation, tissue spectroscopy 11:45-12:30 Fred Verzijlbergen, Translational Imaging & Clinical applications: …. T.b.c. Dept. of Nuclear clinical applications Medicine, Erasmus MC 12:30-13:30 Lunch break ’Quiz master’: Joost Haeck, Erasmus MC > Frank stuurt vroegtijdig verzoek om vragen rond & deadline noemen 13.30-14:15 Special interactive closure of the AMIE Workshop: a plenary quiz as a test and ‘wrap up’ of what you have learned! (With voting machines.) 14.15-15.05 Coordination: Joost Demonstrations; lab visit 5 topics, each group max. 6 Haeck/Yanto Ridwan, (session 3 of 50’) participants (see Wednesday 12 Depts. of Nuclear February) Medicine/ Cell Biology & Genetics and Radiotherapy 15:05-15:20 Coffee break in Ae 4.06 15:20-17:00 Coordination: as Demonstrations; lab visit 5 topics (see above) above (sessions 4 & 5 of 50’) Session 3; 14.15 – 15.05 Group1 Optical Imaging (no CT) Group2 Ultrasound Group3 MRI Group4 SPECT-PET

Session 4; 15:20 – 16:10 Group1 Ultrasound (no SPECT-PET) Group2 MRI Group3 CT Group4 Optical Imaging

Group1 SPECT-PET (no MRI) Session 5; 16:10 – 17:00 Group2 Optical Imaging Group3 Ultrasound Group4 CT

5 Friday, April 14th Moderator: Marion de Jong, Dept. of Nuclear Medicine, Erasmus MC Time Speaker Title Application 09:00-12:00 Coordination: Demonstration with SPECT – MRI All day Jeroen Essers experiments for admitted CT–Optical imaging All day applicants. First come, first Ultrasound (Ee 23.16) ½ day serve-basis. Please All depending on demand & subscribe during the availability workshop. Lunch break 13:00-16:00 Coordination: Cont’d: Demonstration with SPECT – MRI All day Jeroen Essers experiments for admitted CT–Optical imaging All day applicants. First come, first CT – bone imaging ½ day serve-basis. Please All depending on demand & subscribe during the availability workshop.

Attendance fees Course tuition for non-commercial participants is € 550. Discounts are handled as followed:  Participants from the postgraduate school MolMed get a discount of 100% (tuition = €0).  PhD students and Master’s students, regardless of institution, get a discount of 50% (tuition = €275).  Master’s students who are paying the fee from their personal budget get a discount of 75% (tuition = €137,50).

participant category discount tuition

full-tuition, non-commercial 0% € 550

members of MolMed 100% € 0

PhD students, Master’s students (regardless of 50% € 275 institute)

Master’s students paying the tuition from their 75% € 137,50 personal budget

The course is considered an entirety, and participants are encouraged to attend all parts of the course. No discounts are given for participants who chose not to participate in a portion of the course. If these financial requirements pose a problem, please contact Frank van Vliet, managing director of the Erasmus Postgraduate School Mol Med, at: [email protected].

Invoices Fees should only be paid after receipt of an INVOICE. Shortly after your registration you will receive the INVOICE by mail. Payment should be transferred together with the invoice number noted. Late registrations may also pay in cash upon arrival.

Cancellations Cancellation is possible up to one week before the start of the Course. Later cancellation will not be accepted, but you are allowed to send a substitute.

Commercial participants & sponsors Companies are invited to inquire about commercial participant tuition fees and about sponsoring.

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