ADAM15 Antibody Cat. No.: 26-130

ADAM15 Antibody

Antibody used in IHC on Mouse, Rat.

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human, Mouse, Rat

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region IMMUNOGEN: of human ADAM15.

TESTED APPLICATIONS: ELISA, WB

ADAM15 antibody can be used for detection of ADAM15 by ELISA at 1:62500. ADAM15 APPLICATIONS: antibody can be used for detection of ADAM15 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

POSITIVE CONTROL: 1) Cat. No. XBL-10123 - Fetal Brain Tissue Lysate

PREDICTED MOLECULAR 70 kDa WEIGHT:

September 28, 2021 1 https://www.prosci-inc.com/adam15-antibody-26-130.html Properties

PURIFICATION: Antibody is purified by peptide affinity chromatography method.

CLONALITY: Polyclonal

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% BUFFER: sucrose.

CONCENTRATION: batch dependent

For short periods of storage (days) store at 4˚C. For longer periods of storage, store STORAGE CONDITIONS: ADAM15 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.

Additional Info

OFFICIAL SYMBOL: ADAM15

ALTERNATE NAMES: ADAM15, MDC15

ACCESSION NO.: NP_997079

PROTEIN GI NO.: 46909598

GENE ID: 8751

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

ADAM15 is a member of the ADAM (a and ) family. ADAM family members are type I transmembrane known to be involved in adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation- dependent manner, suggesting that this protein may function in cell- as well as in cellular signaling.The protein encoded by this gene is a member of the ADAM (a BACKGROUND: disintegrin and metalloproteinase) . ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.

September 28, 2021 2 https://www.prosci-inc.com/adam15-antibody-26-130.html REFERENCES: 1) Zhong, J.L., (2008) Mol. Cancer Res. 6 (3), 383-394.

ANTIBODIES FOR RESEARCH USE ONLY.

For additional information, visit ProSci's Terms & Conditions Page.

September 28, 2021 3 https://www.prosci-inc.com/adam15-antibody-26-130.html