CLK2 Antibody Cat. No.: 23-254

CLK2 Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 239-498 IMMUNOGEN: of human CLK2 (NP_003984.2).

TESTED APPLICATIONS: WB

APPLICATIONS: WB: ,1:500 - 1:2000

POSITIVE CONTROL: 1) BT-474

2) HeLa

3) Mouse brain

4) Mouse lung

PREDICTED MOLECULAR Observed: 70kDa WEIGHT:

Properties

PURIFICATION: Affinity purification

CLONALITY: Polyclonal

October 2, 2021 1 https://www.prosci-inc.com/clk2-antibody-23-254.html ISOTYPE: IgG

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

STORAGE CONDITIONS: Store at -20˚C. Avoid freeze / thaw cycles.

Additional Info

OFFICIAL SYMBOL: CLK2

ALTERNATE NAMES: Dual specificity protein kinase CLK2, CDC-like kinase 2, CLK2

GENE ID: 1196

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

This encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine- rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this and the BACKGROUND: PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants.

ANTIBODIES FOR RESEARCH USE ONLY.

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October 2, 2021 2 https://www.prosci-inc.com/clk2-antibody-23-254.html