Programme
Wednesday 1 May 2019 14:00 - 16:00 Arrival / Registration with light refreshments ATC Registration Desk and Foyer
16:00 - 16:15 Opening remarks ATC Auditorium
16:15 - 19:25 Session 1: Epigenetic reprogramming Chairs: Caroline Dean and Wolf Reik ATC Auditorium
16:15 - 16:40 Epigenetic inheritance in mammals 1 Anne Ferguson-Smith University of Cambridge, United Kingdom
16:40 - 16:55 Mechanics of DNA replication and transcription guide the 2 asymmetric distribution of RNAPol2 and new nucleosomes on replicated daughter genomes Marta Radman-Livaja CNRS, France
16:55 - 17:10 Investigating the interplay between transcriptional state 3 and cell behaviors in a live mouse Dennis May Yale University, United States of America
17:10 - 17:35 Factors that control transcriptional accuracy and 4 chromatin integrity Fred Winston Harvard Medical School, United States of America
17:35 - 18:05 Coffee break and Meet the speakers with Anne Ferguson-Smith, Fred Winston, Emma Farley, Wolf Reik ATC Auditorium Foyer
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18:05 - 18:30 Regulatory principles governing enhancer function 5 during development Emma Farley University of California, San Diego, United States of America
18:30 - 18:45 Single-allele chromatin interactions identify regulatory 6 hubs in which enhancers can simultaneously activate multiple genes Marieke Oudelaar University of Oxford, United Kingdom
18:45 - 19:00 Immunoprecipitation of plasma cell-free nucleosomes 7 identifies tissue-of-origin and gene expression programs in remote tissues Nir Friedman The Hebrew University of Jerusalem, Israel
19:00 - 19:25 Single cell multi-omics profiling reveals a hierarchical 8 epigenetic landscape during mammalian germ layer specification Wolf Reik Babraham Institute, United Kingdom
19:25 - 21:00 Welcome reception and poster preview (all numbers) ATC Auditorium Foyer and ATC Helix A & B
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Thursday 2 May 2019 09:00 - 12:10 Session 2: Developmental epigenetics Chairs: Anne Ferguson-Smith and Fred Winston ATC Auditorium
09:00 - 09:25 Epigenetic switching in seasonal timing 9 Caroline Dean John Innes Centre, United Kingdom
09:25 - 09:40 Trim28 silences retroviruses by regulating H3.3 deposition 10 and turnover Sharon Schlesinger The Hebrew University of Jerusalem, Israel
09:40 - 09:55 Adding compaction and phase separation activity to Cbx7 11 impacts ES cell differentiation Elizabeth Jaensch Massachusetts General Hospital, United States of America
09:55 - 10:20 Single cell epigenomic analysis of the anatomy and 12 neuronal circuitry of the brain Joseph R. Ecker HHMI & The Salk Institute for Biological Studies, United States of America 10:20 - 10:50 Coffee break and Meet the editors ATC Auditorium Foyer
10:50 - 11:15 Developmental dynamics of histone H4 lysine 16 13 acetylation Asifa Akhtar Max Planck Institute of Immunobiology and Epigenetics, Germany
11:15 - 11:30 The onset of dosage compensation during Drosophila 14 embryogenesis Peter B. Becker LMU Munich, Germany
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11:30 - 11:45 Temporal integration of transcriptional inputs as a 15 mechanism for cell diversification Luisa Cochella IMP - Research Institute of Molecular Pathology, Austria
11:45 - 12:10 Functional insights into genome topology and enhancer 16 function during embryonic development Eileen Furlong EMBL Heidelberg, Germany
12:10 - 13:40 Lunch in the ATC Auditorium Foyer
13:00 - 14:00 Community exchange meeting on the 4DNucleome program (optional/first come first served/during lunch in Courtyard Room A+B)
13:40 - 15:40 Poster Session I (odd numbers) ATC Helix A & B
15:40 - 18:45 Session 3: Different states of chromatin Chairs: Geneviève Almouzni and Nir Friedman ATC Auditorium
15:40 - 16:05 Are phase separation and liquid properties required 17 for heterochromatin function? Gary H. Karpen UC Berkeley, Lawrence Berkeley National Laboratory, United States of America
16:05 - 16:20 New mechanistic insights into histone tail clipping as a 18 novel regulator of chromatin structure and function Judd Rice University of Southern California, United States of America
16:20 - 16:35 Engineered chromatin readers reveal the genome-wide 19 proteome composition at key chromatin states in living cells Tuncay Baubec University of Zurich, Switzerland
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16:35 - 16:50 Patient-specific disease modelling uncovers molecular convergence nce 115 of enhanceropathies: Kabuki and Gabriele de-Vries syndromes Michele Gabriele &VSPQFBO*OTUJUVUFPG0ODPMPHZ, *UBMZ
16:50 - 17:35 Coffee break and Meet the speakers with Caroline Dean, Joseph R. Ecker, Asifa Akhtar, Eileen Furlong, Gary H. Karpen, Amos Tanay ATC Auditorium Foyer
17:35 - 18:00 Understanding epigenetic memory at single cell resolution 21 Amos Tanay Weizmann Institute of Science, Israel
18:00 - 18:15 ABSOLUTE nucleosome occupancy: measuring a missing 22 quantity in chromatin Philipp Korber LMU Munich, Germany
18:15 - 18:30 Phase separation and nucleosome compaction are 23 governed by the same domain of Polycomb Repressive Complex 1 Aaron Plys Massachusetts General Hospital, United States of America
18:30 - 18:45 R-loops enhance Polycomb repression at a subset of 24 developmental regulator genes Konstantina Skourti-Stathaki University of Edinburgh, United Kingdom
18:45 - 19:00 Apéritif ATC Auditorium Foyer
19:00 - 20:30 Dinner EMBL Canteen
20:30 - 22:00 After-dinner drinks ATC Rooftop Lounge
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Friday 3 May 2019 09:00 - 12:10 Session 4: Histone modifications, RNA and metabolism Chairs: Asifa Akhtar and Chris Ponting ATC Auditorium
09:00 - 09:25 Personal regulome navigation 25 Howard Y. Chang Stanford University, United States of America
09:25 - 09:40 G-tract RNA evicts Polycomb Repressive Complex 2 26 from genes Richard G. Jenner University College London, United Kingdom
09:40 - 09:55 The role of histone succinylation in transcription 27 Lara Shahidian Helmholtz Zentrum München - German Research Center for Environmental Health, Germany
09:55 - 10:20 Long noncoding RNAs and chromatin modifiers 28 Igor Ulitsky Weizmann Institute of Science, Israel
10:20 - 10:50 Coffee break ATC Auditorium Foyer
10:50 - 11:15 Genome-wide mapping of protein-DNA interaction dynamics 29 Steven Henikoff 29 Fred Hutchinson Cancer Research Center, United States of America
11:15 - 11:30 Ubiquitin Specific Protease 7 (USP7): Connecting 30 epigenetics, metabolism and tumor suppression Peter Verrijzer Erasmus MC, The Netherlands
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11:30 - 11:45 Epigenome editing of alternatively spliced exons relevant 31 for the EMT is sufficient to change splicing outcome Alexandre Segelle Institute of Human Genetics, France
11:45 - 12:10 Super-resolution imaging of transcription in live 32 mammalian cells Ibrahim Cissé Massachusetts Institute of Technology, United States of America
12:10 - 13:40 Lunch (10x Genomics workshop at 12:55 - 13:40 in Auditorium) ATC Auditorium Foyer
13:40 - 15:40 Poster Session II (even numbers) ATC Helix A & B
15:40 - 18:45 Session 5: Transcriptional and posttranscriptional regulation Chairs: L. Stirling Churchman and Peter Verrijzer ATC Auditorium
15:40 - 16:05 Splicing kinetics revealed by direct sequencing 33 of nascent RNA L. Stirling Churchman Harvard Medical School, United States of America
16:05 - 16:20 Chromatin-sensitive cryptic promoters encode alternative 34 protein isoforms in yeast Vicent Pelechano SciLifeLab, Karolinska Institutet, Sweden
16:20 - 16:35 Two coupled feedback loops explain the onset of random 35 X inactivation in different mammals Verena Mutzel Max Planck Institute for Molecular Genetics, Germany
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16:35 - 17:00 High-throughput mapping of transcription factor binding 36 specificities using microfluidics Polly Fordyce Stanford University, United States of America
17:00 - 17:45 Coffee break and Meet the speakers with Howard Y. Chang, Igor Ulitsky, Steven Henikoff, Ibrahim Cissé, L. Stirling Churchman, Polly Fordyce, Chris Ponting ATC Auditorium Foyer
17:45 - 18:10 Causal links from transcription factor binding 37 to human traits Chris Ponting University of Edinburgh, United Kingdom
18:10 - 18:25 Transcriptional cofactors display core promoter 38 class-specificity Vanja Haberle IMP - Research Institute of Molecular Pathology, Austria
18:25 - 18:40 Binding ≠ function: Linking glucocorticoid receptor binding 39 to the regulation of genes in the endogenous genomic context Sebastiaan Meijsing Max Planck Institute for Molecular Genetics, Germany
18:40 - 18:45 Poster prize announcements ATC Auditorium
18:45 - 19:00 Apéritif ATC Auditorium Foyer
19:00 - 20:30 Dinner EMBL Canteen
20:30 - 22:00 After-dinner drinks ATC Rooftop Lounge
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Saturday 4 May 2019 09:00 - 12:10 Session 6: Nuclear architecture Chairs: Ana Pombo and Gary H. Karpen ATC Auditorium
09:00 - 09:25 Discovering specific chromatin contacts spanning 40 megabases with Genome Architecture Mapping (GAM) Ana Pombo Max Delbrück Center for Molecular Medicine, Germany 09:25 - 09:40 Mapping genome-lamina interactions in the mouse 41 embryo reveals de novo establishment of nuclear architecture Jop Kind Hubrecht Institute, The Netherlands
09:40 - 09:55 Regulation of genome architecture in ground state 42 pluripotent stem cells Raffaella Santoro University of Zurich, Switzerland
09:55 - 10:20 Dissecting chromatin organization using single molecule 43 imaging and genomics Xavier Darzacq University of California, Berkeley, United States of America
10:20 - 10:50 Coffee break ATC Auditorium Foyer
10:50 - 11:05 Poster prize short talk 1 ATC Auditorium
11:05 - 11:20 Poster prize short talk 2 ATC Auditorium
11:20 - 11:45 Enhancer function in the 3D genome – a TAD more 44 complicated Wendy Bickmore MRC Human Genetics Unit, IGMM, University of Edinburgh, United Kingdom
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11:45 - 12:10 Exploring mechanisms of gene silencing and escape 45 in the context of chromosome architecture during X-chromosome inactivation Edith Heard EMBL Heidelberg, Germany
12:10 - 14:30 Lunch EMBL Canteen
14:30 - 17:45 Session 7: Chromatin and its variants in disease Chairs: Andrea Brand and Marc Timmers ATC Auditorium
14:30 - 14:55 Building chromatin: histone variants and chaperones at work 46 Geneviève Almouzni Institut Curie, France
14:55 - 15:10 Unlocking the combinatorial epigenetic code at a 47 single-molecule level Efrat Shema Weizmann Institute of Science, Israel
15:10 - 15:25 Chaperones and transcription complex assembly 48 Marc Timmers DKTK, partner site Freiburg, Germany
15:25 - 15:50 Time to get up: awakening stem cells in the brain 49 Andrea Brand University of Cambridge, United Kingdom
15:50 - 16:35 Coffee break and Meet the speakers with Ana Pombo, Xavier Darzacq, Edith Heard, Geneviève Almouzni, Andrea Brand, Jean-Christophe Marine ATC Auditorium Foyer
16:35 - 17:00 Non-genetic cancer cell plasticity and therapy resistance 50 Jean-Christophe Marine VIB-KU Leuven Center for Cancer Biology, Belgium
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17:00 - 17:15 A functional antagonism between H2A.Z isoforms 51 in gene regulation Didier Trouche CNRS, France
17:15 - 17:30 MLL4 establishes nuclear responsiveness to mechanical 52 stimuli by counterbalancing Polycomb-mediated chromatin compartmentalization Alessio Zippo University of Trento, Italy
17:30 - 17:45 The ChAHP complex counteracts chromatin looping at 53 Ctcf sites that emerged from recent SINE expansions Lucas Kaaij Friedrich Miescher Institute for Biomedical Research, Switzerland
17:45 - 17:55 Closing remarks ATC Auditorium
17:55 - 18:15 Apéritif ATC Auditorium Foyer
18:15 - 20:30 Conference Dinner EMBL Canteen
20:30 - 00:00 Conference Party with band ATC Auditorium Foyer
Poster removal - Please remember to collect your poster. Posters which have not been collected will be disposed of right after the meeting.
Feedback Questionnaire - Check your inbox when the meeting ends. You will find an email from EMBO with a link to our online feedback questionnaire. Please take time to complete it to be able to download your certificate of participation.
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