Cleveland Clinic Laboratories
Technical Brief Comprehensive Metabolic Panel
Background Information Interpretation The Comprehensive Metabolic Panel (CMP) is a standardized Abnormal test results in some cases suggest a disease panel of tests that provides information about the status of process, but may also arise due to statistical deviation from kidneys, liver, electrolyte and acid/base balance, blood sugar a population norm. and blood proteins. These tests include: total protein, Increases or decreases in the measures of albumin, a small albumin, total calcium, total bilirubin, alkaline phosphatase protein produced in the liver, as well as other proteins in (ALP), aspartate aminotransferase (AST), glucose, blood urea serum, can indicate a change in nutritional status. In addition, nitrogen (BUN); creatinine, potassium, chloride, bicarbonate, a variety of acute and chronic illnesses can be indicated by anion gap, alanine aminotransferase (ALT), and estimated measurements of electrolyte (and acid-base) imbalances. glomerular filtration rate (eGFR) for outpatients. Abnormal Increased concentrations of BUN and creatinine in the blood results, particularly in more than one test, may reflect can arise from a decrease in kidney function. Elevated conditions to be further examined by a healthcare provider. concentrations of bilirubin and the enzymes ALP, ALT and Clinical Indications AST suggest liver dysfunction. The CMP is often ordered as part of a blood work-up for a References medical exam or an annual physical, and over time provides 1. Henry’s Clinical Diagnosis and Management by Laboratory a baseline of a patient’s basic physiology. It is used to evaluate Methods, 21st edition. McPherson R, Pincus M, eds. organ function and to check for conditions such as diabetes, Philadelphia, PA; Saunders Elsevier: 2007, P. 147. and liver and kidney disease. It also is used to monitor effects of hypertension and other acute or chronic conditions, as 2. Thomas, Clayton L, Editor (1997). Taber’s Cyclopedic well as to check for side effects in patients who are taking Medical Dictionary. F.A. Davis Company, Philadelphia, PA certain medications. (18th Edition). Blood for the CMP is usually taken after a 10-12 hour fast 3. Pagana, Kathleen D & Pagana, Timothy J. (2001). with no food or liquids (water only). Abnormal test results are Mosby’s Diagnostic and Laboratory Test Reference 5th sometimes followed up with other specific tests to confirm Edition: Mosby Inc., Saint Louis, MO. or rule out a suspected diagnosis. 4. American Medical Association (2002). Current Procedural Terminology, CPT 2002, Standard Edition.
06.13.11 Cleveland Clinic Laboratories 9500 Euclid Avenue, L15, Cleveland, Ohio 44195 800.628.6816 | www.clevelandcliniclabs.com
Test Overview Test Name Comprehensive Metabolic Panel
Methodology Varies according to analyte
Specimen Requirements Volume/Size: 1.0 mL; Type: Plasma; Tube/Container: Lithium heparin (Green)
Minimum Specimen Requirements Volume/Size: 0.5 mL
Alternate Specimen Requirements Volume/Size: 1.0 mL; Type: Serum; Tube/Container: SST (Gold); Transport Temperature: Ambient
Clinical Information Evaluation of metabolic disorders
Billing Code 79629
CPT Code 80053
Technical Information Contact: Scientific Information Contact: Anne Bordner Blank, MBA, MT(ASCP) Edmunds Z. Reineks, MD, PhD 216.444.2173 216.444.9143 [email protected] [email protected]
201106.035