USOO9456967B2

(12) United States Patent (10) Patent No.: US 9,456,967 B2 Cohen (45) Date of Patent: *Oct. 4, 2016

(54) COMPOSITION CONTAINING A (56) References Cited CELLULOSE DERVED CAPSULE WITH A SUNSCREEN U.S. PATENT DOCUMENTS 3,462.479 A 8, 1969 Strobel et al. (71) Applicant: CoLabs International Corporation, 3,691,270 A 9, 1972 Charle et al. Las Vegas, NV (US) 4,402.977 A 9, 1983 Grollier et al. 4,540,507 A 9, 1985 Grollier 4,542,125 A 9, 1985 Gorman et al. (72) Inventor: Laura E. Cohen, Huntington Beach, 4,663,155 A 5/1987 Murray et al. CA (US) 4,663,156 A 5, 1987 Clum et al. 4,683,134 A 7, 1987 Palinczar (73) Assignee: CoLabs International Corporation, 4,686,099 A 8, 1987 Palinczar 4,699,779 A 10, 1987 Palinczar Las Vegas, NV (US) 4,701,321 A 10, 1987 Bernstein 4,749,501 A 6/1988 Nakagawa et al. (*) Notice: Subject to any disclaimer, the term of this 4,803, 195 A 2f1989 Holzner patent is extended or adjusted under 35 4,874,538 A 10, 1989 Dawson et al. U.S.C. 154(b) by 220 days. 4,904,524 A 2, 1990 Yoh 4,933,174 A 6, 1990 Bernstein This patent is Subject to a terminal dis 4,985,170 A 1/1991 Dawson et al. claimer. 5,071,706 A * 12/1991 Soper ...... A61K 8/11 264/43 5,169,624 A 12/1992 Ziegler et al. (21) Appl. No.: 14/269,127 5,292,801 A 3, 1994 Avnir et al. 5,300,564 A 4, 1994. Avnir et al. (22) Filed: May 3, 2014 5,306.485 A 4, 1994 Robinson et al. 5,455,048 A 10, 1995 Lahmani et al. 5,476,660 A 12/1995 Somasundaran et al. (65) Prior Publication Data 5,508,259 A 4/1996 Holzner et al. US 2014/0242131 A1 Aug. 28, 2014 5,543,136 A 8, 1996 Aldous 5,589,177 A 12/1996 Herb et al. (Continued) Related U.S. Application Data FOREIGN PATENT DOCUMENTS (63) Continuation of application No. 14/072.926, filed on Nov. 6, 2013. CN 1341012 A 3, 2002 EP OO25379 B1 6, 1984 (60) Provisional application No. 61/769,758, filed on Feb. 27, 2013, provisional application No. 61/722,870, (Continued) filed on Nov. 6, 2012. OTHER PUBLICATIONS (51) Int. C. A6 IK 8/06 (2006.01) Boissiere, et al. “Turning biopolymer particles into hybrid capsules: A61O 1704 (2006.01) the example od silicatalginate nanocomposites' J. Mater. Chem. A6 IK 8/35 (2006.01) 2006; 16:1178-1182. A6 IK 8/II (2006.01) (Continued) A6 IK S/37 (2006.01) A61O 5/02 (2006.01) A6 IK 8/73 (2006.01) Primary Examiner — Abigail Fisher BOI. I3/02 (2006.01) Assistant Examiner — Daniel Branson A61O 17/00 (2006.01) A61 O 19/00 (2006.01) (74) Attorney, Agent, or Firm — One3 IP Management, A61 O 19/10 (2006.01) P.C.; Dean G. Stathakis; Peter D. Weinstein A61O 5/06 (2006.01) A61O 5/12 (2006.01) (57) ABSTRACT (52) U.S. C. CPC ...... A61K 8/II (2013.01); A61K 8/062 A Sunscreen composition comprised of one or more Sun (2013.01); A61K 8/35 (2013.01); A61K 8/37 screen active agents encapsulated in a cellulose derived (2013.01); A61K 8/731 (2013.01); A61O 5/02 capsule wherein the composition can contain one or more (2013.01); A61O 1704 (2013.01); B01J 13/02 additional agents. A Sunscreen composition can be mixed (2013.01); A61 K 2800/21 (2013.01); A61 K with a bodywash, shampoo, conditioner, lotion, gel, Soap, 2800/412 (2013.01); A61O 5/06 (2013.01); cream, hand sanitizer, spray or mousse and can be used by A61O 5/12 (2013.01); A61O 17/005 (2013.01); an individual during their normal hygiene processes. Such as A61 O 19/007 (2013.01); A61O 19/10 during a shower or bath or while applying a body product to (2013.01) their skin or hair. (58) Field of Classification Search None See application file for complete search history. 20 Claims, No Drawings US 9,456,967 B2 Page 2

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S 120 to U.S. Non-Provisional Ser. No. through Such products as shampoo, body wash, conditioner, 14/072,926, filed Nov. 6, 2013, which claims priority pur lotion, mousse, spray, hand sanitizer, cream and gel. suant to 35 U.S.C. S 119(e) to U.S. Provisional Patent Application 61/769,758, filed Feb. 27, 2013 and U.S. Pro SUMMARY visional Patent Application 61/722,870, filed Nov. 6, 2012, 10 each of which is hereby incorporated by reference in its In an aspect, the present invention discloses a Sunscreen entirety. composition comprising a Sunscreen active agent encapsu lated in a cellulose derived capsule and one or more addi BACKGROUND tional agents. In a further aspect the present invention 15 discloses that a Sunscreen composition is combined with a Overexposure to ultraviolet (“UV) radiation produced by bodywash, shampoo, conditioner, gel, Soap, hand sanitizer, the sun can result in deleterious effects to individuals, cream, spray, mousse or lotion. In an aspect, the present including, Sunburn, premature aging of skin, premature invention discloses that a Sunscreen active agent included in wrinkling, and for many individuals, an increase in the risk a sunscreen composition absorbs or blocks UV radiation of skin cancer. To avoid these adverse effects, it is common from about 290 to about 420 nm. In an aspect, the present for individuals prior to exposure to Sunlight to apply a invention discloses that a Sunscreen active agent is an Sunscreen product to their skin. Such products are widely inorganic physical blocker of UVA Solar radiation, an inor available and relatively inexpensive. However, many indi ganic physical blocker of UVB solar radiation, an iron oxide viduals fail to use them on a regular basis for reasons that or a polymer or a polyethylene. include, without limitation, convenience of use and the feel 25 In another aspect, the present invention discloses a Sun of the product after application. Additionally, these products screen composition, wherein the composition comprises Suffer from other issues such as uneven application and their one, two, three, four or more Sunscreen active agents. In a inability to provide adequate protection due to loss of further aspect, the present invention discloses that the SPF coverage suffered from Such activities as Swimming, exer protection provided by a Sunscreen active agent in the cise that results in perspiration and dermal penetration and 30 composition is from about 1 to 70, is from about 1 to about Subsequent excretion through the urine of the active agents 50, or about 2 to about 50, or about 2 to about 40, or about incorporated in the sunscreen product that protects an indi 2 to about 30, or about 2 to about 20, or about 2 to about 10, vidual from the Sun's harmful UV radiation (hereinafter or about 2 to about 5, or about 5 to about 25, or about 5 to referred to as "Sunscreen active agents'). about 20, or about 5 to about 15, or about 5 to about 10. In To provide more convenient, consistent and even Sun 35 another aspect the present invention discloses that the SPF screen protection, several products that are used by indi protection provided by a Sunscreen composition in the viduals on a regular basis have been developed that incor composition is at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, porate Sunscreen active agents that protect an individual 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, from the Sun's harmful UV radiation. In the United States, 30, 31, 32, 33, 34, 35, 36, 37,38, 39, 40, 41, 42, 43, 44, 45, it is common for individuals to bathe or shower on a regular 40 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, basis, in most instances, every day. It is also common for 62, 63, 64, 65, 66, 67,68, 69, 70, 71, 72,73, 74, 75, 76, 77, those same individuals to use a body wash, shampoo, 78, 79,80, 81, 82, 83, 84,85, 86, 87, 88, 89,90, 91, 92,93, conditioner, lotion or cream while they shower. Therefore, 94, 95, 96, 97,98, 99, 100 or more and/or the SPF protection products have been developed that include Sunscreen active provided by a Sunscreen composition in the composition agents in bodywashes and shampoos. Other products that 45 remains above about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, have been developed to include Sunscreen active agents are 14, 15, 16, 17, 18, 19, or 20, 21, 22, 23, 24, 25, 26, 27, 28, make-up, lip balm and even hair spray products. Though the 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, use of these products adds convenience, they generally have 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, not overcome some of the other issues related to the use of 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72,73, 74, 75, 76, Sunscreen products. 50 77,78, 79,80, 81, 82, 83, 84,85, 86, 87, 88, 89,90,91, 92, Nevertheless, in spite of all the above attempts, there 93, 94, 95, 96, 97, 98, 99, 100 or more and/or the SPF remains an unmet need for an effective Sunscreen product protection provided by the composition lasts at least about that provides an effective level of sun protection, particularly 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, a level of Sun block or Sunscreen that is higher than existing 19, 20, 21, 22, 23, 24, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, formulations and remains effective even after rinsing one or 55 75, 80, 85, 90, 95, 100 hours or more and/or the SPF more times following application as well as having a gentle protection provided by the composition lasts for an average or acceptable feel on the human skin, as opposed to an oily of at least about 1 day, 2 days, 3 days, 4 days, 5 days, 6 days, feel. The present invention addresses one or more of these 7 days, 8 days, 9 days, 10 days, 11 days, 12 days, 13 days, needs by utilizing encapsulation technologies, milder Sur 14 days, after rinsing. factant systems, and good adhesive polymers that provide a 60 In an aspect, the present invention discloses that the SPF strong binding capability, making it more efficient for depo protection provided by the composition increases after each sition of Sunscreen. The present invention adds cellulose additional application. In a further aspect, the present inven derived capsules that contain one or more Sunscreen active tion discloses that the SPF protection provided by the agents, resulting in an increase in SPF in the formulation as composition increases after each additional application So compared to free Sunscreen or non-encapsulated material. 65 that after a second, third, fourth, fifth, sixth, seventh, eighth, The cellulose derived capsules of the present invention also ninth, tenth, eleventh or more washes, the SPF provided can lay down on the skin Surface in a manner that result in a be above about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, US 9,456,967 B2 3 4 16, 17, 18, 19, or 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, particle sizes of titanium dioxide and/or comprises a mixture 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, of coated and uncoated titanium dioxide. In an aspect, the 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, present invention discloses that a composition comprises a 63, 64, 65,66, 67, 68, 69, 70, 71, 72, 73,74, 75, 76, 77, 78, Sunscreen active agent is encapsulated or two or more 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89,90,91, 92,93, 94, Sunscreen active agents are encapsulated and/or a Sunscreen 95, 96, 97,98, 99, 100 or more. composition comprises one or more Sunscreen active agents. In an aspect, the present invention discloses that a Sun In an aspect, the present invention discloses that the ratio screen composition includes a cationic polymer, and further, of Sunscreen composition to bodywash, shampoo, condi wherein the cationic polymer can be a quarternium or a tioner, lotion, gel, Soap, cream, hand sanitizer, spray or polyguarternium. In a further aspect, the present invention 10 mousse is about 0.2,0.5,0.7 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, discloses that a film former is dimethicone and/or petrolatum 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0, and/or a preservative is BHT and/or an additional agent is an 3.2, 3.5, 3.7, 4.0, 4.2, 4.5, 4.7, 5.0, 6.0, 7.0, 8.0, 9.0, 10; 12, antioxidant, a chelating agent, a liquid hydrocarbon, a foam 15, or 20 parts bodywash, shampoo, lotion, conditioner, gel. ing agent, a skin nourishing Substance, Sunless tanning Soap, hand sanitizer, cream, spray or mousse to Sunscreen actives, skin lightening actives, skin whitener, a hindered 15 active agent as measured w/w. amine light stabilizers, anti-acne actives, anti-skin wrinkling In an aspect, the present invention discloses that the pH of and anti-skin aging actives, vitamins, anti-inflammatory the sunscreen composition is from about 6 to about 8, about actives, anesthetic actives, analgesic actives, anti-pruritic 6.7 to about 7.5 or about 4.0 to about 10. In a further aspect, actives, anti-microbial actives (e.g. antifungals, antibacteri the present invention discloses that the pH of the composi als, and antiparasitics), anti-virals, anti-allergenics, medici tion is at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14. nal actives (e.g., skin rash, skin disease and dermatitis In an aspect, the present invention discloses that a cellu medications), anti-cellulite additives, hindered amine light lose derived capsule contains one Sunscreen active agent or stabilizers, insect repellant actives, antioxidants, hair growth two or more Sunscreen active agents and further, wherein the promoters, hair growth inhibitors, hair bleaching agents, cellulose derived capsule can be flexible and further, Vitamins, deodorant compounds, or more. In a further 25 wherein the cellulose derived capsule has a high load rate. embodiment, Sunless tanning actives include, without limi In an aspect, the present invention discloses that a cellulose tation, dihydroxyacetone (DHA): glyceryl aldehyde; tyro derived capsule is comprised of hydroxypropylcellulose, sine and tyrosine derivatives Such as malyltyrosine, tyrosine hydroxypropylmethylcellulose, ethylcellulose, carboxym glucosinate, and ethyltyrosine; phospho-DOPA, indoles and ethylcellulose or any derivatives therefrom and, wherein, the derivatives. In a further embodiment, skin lightening actives 30 cellulose derived capsule can have a diameter of about 400 include, without limitation, EMBLICA (also an antioxidant), nm to about 700 nm. In an additional embodiment, a monobenzone (a depigmenting agent), kojic acid, arbutin, cellulose derived capsule has a diameter of about 400 nm to ascorbic acid and derivatives thereof (e.g., magnesium about 650 nm, about 400 nm to about 600 nm, about 400 nm. ascorbyl phosphate or Sodium ascorbyl phosphate), and to about 550 nm, about 400 nm to about 500 nm, about 400 extracts (e.g., mulberry extract, placental extract). 35 nm to about 450 nm, about 200 nm to about 750 nm, about In an aspect, the present invention discloses that a com 250 nm to about 700 nm, 300 nm to about 600 nm or about position is applied topically and/or sprayed. In an aspect, the 300 nm to about 700 nm. In a further embodiment, 75% or present invention discloses that an additional agent is a more of the cellulose derived capsules have a diameter of Surfactant and the Surfactant can be cationic, anionic, non about 300 nm to about 600 nm. In a further embodiment, a ionic, Zwitterionic, amphoteric, or any combination thereof 40 cellulose derived capsule has a diameter of at least 25 nm, and/or organic or inorganic, further, wherein, a Sunscreen at least 50 nm, at least 75 nm, at least 100 nm, at least 125 composition can include an additional agent to treat a nm, at least 150 nm, at least 175 nm, at least 200 nm, at least condition suffered by an individual. In a further aspect, the 225 nm, at least 250 nm, at least 275 nm, at least 300 nm, present invention discloses that a Sunscreen composition can at least 325 nm, at least 350 nm, at least 375 nm, at least 400 be used to treat Seborrheic dermatitis, eczema, Xerosis, 45 nm, at least 425 nm, at least 450 nm, at least 475 nm, at least infestation, dyschromia, keratosis pilaris, acne, anti-aging, 500 nm, at least 525 nm, at least 550 nm, at least 575 nm, sensitive skin, ephilidies, Solar lentigines, photo sensitive at least 600 nm, at least 625 nm, at least 650 nm, at least 675 disease, skin cancer and hx of skin cancer, melisma, auto nm, at least 700 nm, at least 725 nm, at least 750 nm, at least immune, alopecia, fungal, bacterial, and viral infections, 775 nm, at least 800 nm, at least 825 nm, at least 850 nm, protect colored or treated hair, bromhidrosis, malodor, dan 50 at least 875 nm, at least 900 nm, at least 925 nm, at least 950 druff, wound healing, insect repellant, pet shampoofskin nm, at least 975 nm, at least 1000 nm or more. care, lindane or similar conditions. In an aspect, the present invention discloses that a Sun In an aspect, the present invention discloses that a Sun screen composition comprises water, a chelating agent, a screen active agent is titanium dioxide and the titanium moisturizing agent, a preservative, a thickening agent, a dioxide can have an anatase, ritile or amorphous structure 55 silicone containing compound, an essential oil, a structuring and the titanium dioxide can be uncoated or coated and can agent, a vitamin, a pharmaceutical ingredient, or an antioxi be coated with aluminum compounds, including, without dant, or any combination of Such ingredients or mixtures of limitation, aluminum oxide, aluminum Stearate or aluminum Such ingredients and further, wherein the Sunscreen compo laurate or can be coated with phospholipids or silicone sition includes, without limitation, at least two, three, four, compounds. In a further aspect, the present invention dis 60 five, six, seven, eight, nine, ten, or more additional agents closes that titanium dioxide can be micronized and has a and further, wherein the additional agents can have a con mean primary particle size ranging from about 10 nm to centration that is from about 0.0001% to about 99.9% (w/v). about 50 nm or a micronized mean primary particle size of In an aspect, the present invention discloses that one or more 15 nm and/or the titanium dioxide is uncoated and if additional agents are encapsulated or one or more additional uncoated titanium dioxide can have a mean particle size of 65 agents are not encapsulated. In an aspect, the present inven around 35 nm to about 50 nm. In a further aspect, the present tion discloses that one or more additional agents are not invention discloses that a mixture of two or more different encapsulated. US 9,456,967 B2 5 6 In an aspect, the present invention discloses that a Sun derived capsule or not. In a further aspect, the present screen composition increases the protection of an individual invention discloses that an additional agent treats hair loss to which the composition is applied. In a further aspect, the that can be encapsulated in a cellulose derived capsule or present invention discloses that the concentration of a Sun not. In a further aspect, the present invention discloses that screen active agent that is a UVA or a UVB absorber is from an additional agent is hair bleaching agent that can be of about 1% to about 40%, or about 2% to about 20%, or encapsulated in a cellulose derived capsule or not. In a about 2% to about 10%, or about 5% to about 10%, or about further aspect, the present invention discloses that an addi 1%, 2%, 3%, 4%, 5%, 6%, 7%, 7.4%, 7.5%, 7.6%, 8%, 9%, tional agent is a deodorant that can be encapsulated in a 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, cellulose derived capsule or not. In a further aspect, the 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 10 present invention discloses that an additional agent is an 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39% or anti-oxidant active that can be encapsulated in a cellulose 40% (w/v). In a further aspect, the present invention dis derived capsule or not. In a further aspect, the present closes that a cellulose derived capsule is prepared so as to invention discloses that an additional agent is photostable experience breakage in the range of about 0, 0.1, 0.5, 1, 2, antioxidant that can be encapsulated in a cellulose derived 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 15 capsule or not. In a further aspect, the present invention 21, 22, 23, 24, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, discloses that an additional agent is an insect repellent that 85, 90 or 95% to about 0.50.1, 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, can be encapsulated in a cellulose derived capsule or not. In 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, a further aspect, the present invention discloses that an 30, 35, 40, 45, 50, 55, 60, 65,70, 75, 80, 85,90 or 95% after additional agent is a polyguarternium and/or a cationic application or the cellulose derived capsule is prepared so as active that can be encapsulated in a cellulose derived capsule to experience breakage in response to conditions that occur or not. In a further aspect, the present invention discloses on the skin or hair and can be in response to conditions that that an additional agent is film barrier system that can be occur on the skin or hair in a time release or controlled encapsulated in a cellulose derived capsule or not. In a manner. In an additional aspect, the present invention dis further aspect, the present invention discloses that an addi closes that an additional agent is a vitamin that can be 25 tional agent is a film former that can be encapsulated in a encapsulated in a cellulose derived capsule or not. In a cellulose derived capsule or not. In a further aspect, the further aspect, the present invention discloses that an addi present invention discloses that an additional agent is a tional agent is an anti-acne active that can be encapsulated secondary film former that can be encapsulated in a cellulose in a cellulose derived capsule or not. In a further aspect, the derived capsule or not. In a further aspect, the present present invention discloses that an additional agent is an 30 invention discloses that an additional agent is a preservative. anti-skin wrinkling active that can be encapsulated in a In a further aspect, the present invention discloses that an cellulose derived capsule or not. In a further aspect, the additional agent is a chelating agent that can be encapsulated present invention discloses that an additional agent is a in a cellulose derived capsule or not. In a further aspect, the botox active that can be encapsulated in a cellulose derived present invention discloses that an additional agent is a capsule or not. In a further aspect, the present invention 35 thickening agent or gellant that can be encapsulated in a discloses that an additional agent is an anti-skin aging or cellulose derived capsule or not. In a further aspect, the anti-wrinkling active that can be encapsulated in a cellulose present invention discloses that an additional agent is fra derived capsule or not and further, wherein anti-skin aging grance, dye and/or antimicrobial that can be encapsulated in or anti-wrinkling additional agents can be a bicyclic aro a cellulose derived capsule or not. In a further aspect, the matic compounds, compounds which have retinoid-type 40 present invention discloses that an additional agent is a activity, free-radical Scavengers, hydroxy or keto acids or Surfactant that can be encapsulated in a cellulose derived derivatives thereof, further, wherein an anti-skin aging or capsule or not. In an aspect, the Surfactant results in reduced anti-wrinkling additional agents are Sulfur-containing D and lathering or results in lathering and/or the Surfactant is an Lamino acids and their derivatives and salts, phospholipids anionic Surfactant, a taurate, a nonionic Surfactant, a ampho (e.g., distearoyl lecithin phospholipid), fatty acids, fatty 45 teric lathering Surfactant, a amphoteric Surfactant or a cat alcohols, cholesterol, plant sterols, phytic acid, lipoic acid; ionic Surfactant. In a further aspect, the present invention lysophosphatidic acid, and skin peel agents (e.g., phenol and discloses that an additional agent is a quenching agent that the like), and mixtures thereof. In a further aspect, the can be encapsulated in a cellulose derived capsule or not. In present invention discloses that an additional agent is an a further aspect, the present invention discloses that an anti-inflammatory active that can be encapsulated in a 50 additional agent is a thickening agent or gellant that can be cellulose derived capsule or not. In a further aspect, the encapsulated in a cellulose derived capsule or not. In a present invention discloses that an additional agent is anes further aspect, the present invention discloses that an addi thetic that can be encapsulated in a cellulose derived capsule tional agent is a hindered amine light stabilizers that can be or not. In a further aspect, the present invention discloses encapsulated in a cellulose derived capsule or not. In a that an additional agent is an analgesic that can be encap 55 further aspect, the present invention discloses that an addi sulated in a cellulose derived capsule or not. In a further tional agent is a skin whitener that can be encapsulated in a aspect, the present invention discloses that an additional cellulose derived capsule or not. agent is an antimicrobial or antifungal that can be encapsu In an aspect, the present invention discloses that the lated in a cellulose derived capsule or not. In a further Sunscreen composition can be applied once per day, applied aspect, the present invention discloses that an additional 60 two, three, four or more times per day, applied every other agent is an anti-viral that can be encapsulated in a cellulose day or applied about 10, 8, 7, 6, 5, 4, 3, 2 or 1 time per week. derived capsule or not. In a further aspect, the present In a further aspect, the present invention discloses that a invention discloses that an additional agent treats dermato Sunscreen can be applied to wet skin and/or hair or applied logical conditions that can be encapsulated in a cellulose to dry skin and/or hair. In a further aspect, the present derived capsule or not. In a further aspect, the present 65 invention discloses that a Sunscreen composition contains invention discloses that an additional agent is an anti one, two or more Surface-treated metal oxide pigments that cellulite active that can be encapsulated in a cellulose block UV radiation, further, wherein the surface-treated US 9,456,967 B2 7 8 metal oxide can block UV radiation in the wavelength range position is 1.5-2.7. In a further aspect, the present invention of from about 290 nm to about 400 nm. discloses that the composition contains cellulose derived In an aspect, the present invention discloses that a cellu capsules of different sizes and the inner refractive index of lose derived capsules containing Sunscreen active agents are the composition is greater than 1.5. in the 400-450 nm range, the 400-500 nm range, the 400-550 In an aspect, the present invention discloses that the nm range, the 400-600 nm range, the 400-650 nm range. In composition contains cellulose derived capsules, further a further aspect, the present invention discloses that the wherein, the mixture of cellulose derived capsules contains cellulose derived capsules contain an active coating on the capsules containing different cellulose derivatives and the exterior of the cellulose derived capsule membrane which inner refractive index of the composition is greater than 1.5. has absorption properties. In a further aspect, the present 10 In a further aspect, the present invention discloses that the invention discloses that the cellulose derived capsules are of composition has an overall refractive index of 1.4-2. different sizes. In a another aspect, the present invention discloses that the cellulose derived capsule is comprised of DETAILED DESCRIPTION 0.1%-5% wit/wt of cellulosic material, 5%-20% wit/wt of cellulosic material, 20%-50% wit/wt of cellulosic material or 15 The present invention encompasses compositions con 50%–70% wit/wt of cellulosic material. In a further aspect, taining one or more Sunscreen active agents capable of the present invention discloses that the cellulose derived protecting an individual from the deleterious effects of capsule is comprised of two or more layers, further, wherein exposure to the sun's harmful UV radiation (hereinafter, each layer can contain a different Sunscreen active agent, referred to as 'sunscreen active agent or Sunscreen active wherein each layer ca contain the same Sunscreen active agents') in a cellulose derived capsule that may be added, agent, wherein each layer can contain a different Sunscreen without limitation, to a bodywash, a shampoo, a conditioner, active agent, wherein at least one layer can contain a a gel, a hand sanitizer, a cream, a spray, a mouse or a lotion different Sunscreen active agent than at least one other layer, (hereinafter referred to as a “combination product”). In an wherein at least one layer can contain a Sunscreen active embodiment, the invention relates to a cellulose derived agent and at least one layer contains an antioxidant, wherein 25 capsule that encompasses a Sunscreen composition, wherein at least one layer can contain a Sunscreen active agent and the Sunscreen composition comprises one or more Sunscreen at least one layer contains a vitamin, wherein at least one active agents, further wherein the Sunscreen composition is layer can contain a Sunscreen active agent and at least one a solid or a liquid. In a further embodiment, the Sunscreen layer contains an anti-inflammatory, wherein at least one composition also contains one or more additional agents that layer can contain a Sunscreen active agent and at least one 30 can include, without limitation, Surfactants, polymers, anti layer contains an astringent. microbials, vitamins, antioxidants, pigments, fragrances, In an aspect, the present invention discloses that a Sun hindered amine light stabilizers, skin whitener and other screen composition can be comprised of a cationic Surfac additional agents that after administration by an individual, tant, a cellulose derived capsule and a polymer, can be deposit an active agent on a Substrate, for example, without comprised of an anionic Surfactant, cellulose derived encap 35 limitation, an individual’s skin or hair, forming a film that Sulate, and a polymer, can be comprised of a nonionic reflects or absorbs to some degree the harmful radiation Surfactant, cellulose derived encapsulate, and a polymer, can from the sun or attenuates the harmful effect of ultraviolet be comprised of an amphoteric Surfactant, cellulose derived radiation and with certain active agents, provides an addi encapsulate, and a polymer, wherein the composition can be tional benefit. The present invention provides a body wash, comprised of a Surfactant containing a quat group, wherein 40 shampoo, conditioner, gel, hand sanitizer, cream, spray, said quat group is capable of absorbing UV radiation, can be mousse or a lotion that is formulated so that it may be comprised of a Surfactant metal complex to enhance reflec applied during normal hygienic activities, such as washing, tive properties, can be comprised of more than one surfac moisturizing or other normal hygiene activities, such that the tant, a cellulose derived capsule and a polymer, can be combination product results in the application of an effective comprised of a cellulose derived capsule comprising ethyl 45 level of a Sunscreen active agent encapsulated in a cellulose cellulose and a Surfactant base containing one or more derived capsule to the body such that the sunscreen active polymers, can be comprised of a cellulose derived capsule agent continues to provide effective Solar protection even comprising carboxymethyl cellulose and a Surfactant base after rinsing or washing of an individual’s body. containing one or more polymers. In an embodiment, a Sunscreen active agent comprises a In an aspect, the present invention discloses that a Sun 50 sunscreen additive that absorbs or reflects some or all of the screen active agent is an organic or non-polar highly refrac sun's ultraviolet (“UV) radiation on the skin of an indi tive Sunscreen active agent, or a Sunscreen active agent is an vidual exposed to Sunlight and thus, helps to protect an organic Sunscreen active agent and wherein, the composition individual against overexposure to the UV radiation. Sun contains inorganic metals. In an aspect, the present invention screen active agents commonly contain one or more of the discloses that a Sunscreen composition comprises a Surfac 55 following ingredients: an organic chemical compound that tant, a polymer and a cellulose derived capsule, further absorbs UV radiation, inorganic particulates that reflect, wherein, the composition is comprised of one or more scatter and/or absorb UV radiation (such as titanium dioxide, different cellulose derived capsules, each comprised of a Zinc oxide, or a combination of both) and organic particu different cellulose derivative. lates that mostly absorb light like organic chemical com In an aspect, the present invention discloses that the inner 60 pounds. In an embodiment, a Sunscreen composition can refractive index of a Sunscreen composition is 1.5-1.7, is include a Surfactant metal complex to enhance the reflective 1.5-1.9, is 1.5-2.2, is 1.5-2.4, is 1.5-2.6. In a further aspect, property of a Sunscreen composition containing a Sunscreen the present invention discloses that the inner refractive index active agent. In a further embodiment, a cellulose derived of a non-sunscreen active agent in the composition is capsule membrane can increase the absorption properties of 1.5-2.7. In an additional aspect, the present invention dis 65 a Sunscreen formulation. closes that the inner refractive index of a non organic In an embodiment, a Sunscreen active agent is combined dispersed with organic Sunscreen active agent in the com with a bodywash, shampoo, conditioner, gel, hand sanitizer, US 9,456,967 B2 10 cream, lotion, spray or mousse and can include, without tion, the following ingredients: moisturizers, reconstructors, limitation, a additional agent to form a combination product. acidifiers, detanglers, thermal protectors, glossers, oils, Sur In an embodiment, a bodywash includes, without limitation, factants, lubricants, sequestrants, antistatic agents, preser a lathering bodywash or a non-lathering bodywash. In an Vatives and Sunscreen active agents. In an embodiment, a embodiment, a bodywash includes, without limitation, an conditioner includes, without limitation, a pack conditioner, emulsion of water and detergent base with added fragrance a leave-in conditioner, an ordinary conditioner that includes and is a skin cleaning agent commonly used in a shower or both pack and leave-in ones and hold conditioners. bath. In an embodiment, a body wash includes, without In an embodiment, a hand sanitizer includes, without limitation, popular brands Such as Fa, Palmolive, Axe, Lynx, limitation, isopropanol, ethanol, n-propanol or povidone Radox, Nivea, Johnson, Senses, Adidas, Umbro, Old Spice, 10 iodine. In a further embodiment, hand sanitizers can contain Imperial Leather and right guard. In an embodiment, a the following inactive ingredients, without limitation, a bodywash contains a milder Surfactant than a shampoo. In a thickening agent, including without limitation, polyacrylic further embodiment, a bodywash includes, without limita acid for alcohol gels, humectants, including without limita tion an all-in-one multifunctional, moisturizing cleanser that tion, glycerin for liquid rubs, propylene glycol and essential both provides SPF and imparts color to the skin after 15 oils derived from plants. In an embodiment, a hand sanitizer application, wherein the bodywash includes, without limi is a non-alcohol hand sanitizer, which includes without tation, iron oxide pigments as well as red petrolatum, at least limitation, a nitrogenous cationic Surface-acting agent, that one, preferably two, anionic lathering Surfactants, a non include, without limitation, benzalkonium chloride, tri ionic lathering Surfactant, Surface-treated Zinc oxide pig closan or povidone-iodine. ments, an alkyl silicone and a volatile cyclic silicone. In an embodiment, a Soap is a salt of a fatty acid. Soaps In an embodiment, a spray includes, without limitation, an for cleansing are generally obtained by treating vegetable or aerosol spray. In a further embodiment, a spray includes, animal oils and fats with a strongly alkaline Solution. Soaps without limitation, hair spray, body spray, for example, can be in a Solid form, Such as a bar or in a decorative shape. without limitation, those sold by AXE, spray on insect Soap can also be a liquid. Other components can be added protection and spray on deodorant. In one aspect of the 25 to Soap, without limitation, including oils, fragrances and present invention, the SPF liquid cleansing composition is conditioners. In a further embodiment, a Soap contains a aerosolized. In a further embodiment, the aerosol spray Surfactant. In another embodiment, a soap does not contain includes, without limitation, a propellant. In an additional a Surfactant. embodiment, a propellant is, without limitation is a mixture In an additional embodiment, a Soap is a melt and pour of isobutane, butane and propane, including, without limi 30 Soap. The process for a melt and pour soap differs from the tation A46, AP30 (11% Propane, 29% Isobutane, 60% cold process, hot process or rebatching process of making n-butane); AP40 (22% Propane, 24% Isobutane, 54% n-bu soap in that no soap is made (i.e. no actual saponification tane); and AP70 (31% Propane, 23% Isobutane, 46% n-bu occurs) in the process; a melt and pour soap base acquired tane). in commerce is melted in a direct heat melter or water jacket In an embodiment, a shampoo includes, without limita 35 melting pot (large double boiler) and additional items such tion, sodium lauryl sulfate and/or sodium laureth sulfate as fragrance, essential oils, moisturizing agents, colorants, or with a co-surfactant, including, without limitation, cocami exfoliating agents are added. While still hot, the concoction dopropyl betaine in water to form a thick, Viscous liquid. In can be poured into individual molds, tray molds, or blocks a further embodiment, a shampoo includes salt, including, which upon cooling can be sliced. In an embodiment, a melt without limitation, Sodium chloride, a preservative and a 40 and pour Soap is a clear glycerin Soap or a white soap made fragrance. In an embodiment, a shampoo is formulated to from white coconut oil. maximize the following qualities, without limitation, pleas In an embodiment, a soap is Castile soap. Castile soap is ing foam, easy rinsing, minimal skin or eye irritation, feels a name used in English-speaking countries for olive oil thick and/or creamy, pleasant fragrance, low toxicity, good based soap made in a style similar to that originating in the biodegradability, slightly acidic and no or minimal damage 45 Castile region of Spain. In an embodiment, Castile soap to hair. includes, without limitation, sodium hydroxide, potassium In a further embodiment, a lotion includes, without limi hydroxide and/or ash. tation, a low to low medium Viscosity topical preparation In an embodiment, a shampoo, bodywash, conditioner, intended for application to unbroken skin. In an embodi gel, Soap, cream or lotion combination product is applied by ment, a lotion is an oil-in-water emulsion that includes, 50 hand, washcloth, or any cleansing article Such as a brush, without limitation, cetearyl alcohol and an emulgent to loofah, pouf, sponge, or other to an individual. prevent separation of these two phases. In an embodiment, The Sun protection factor of a Sunscreen is a laboratory a lotion contains, without limitation, fragrances, glycerol, measure of the effectiveness of sunscreen. What this means petroleum jelly, dyes, preservatives, proteins and stabilizing is that the higher the SPF, the more protection a sunscreen agents. In an embodiment, lotions include, without limita 55 offers against UV-B radiation (the ultraviolet radiation that tion a skin medication Such as an antibiotic, antiseptic, causes sunburn). The SPF is the amount of UV radiation antifungal, corticosteroid, anti-acne agents or soothing, required to cause Sunburn on the skin with the Sunscreen on, Smoothing, moisturizing or protective agents, including, as a multiple of the amount required without the Sunscreen. without limitation, calamine. In an embodiment, a gel SPF is determined by measuring the Minimal Erythemal includes, without limitation, a solid, jelly-like material that 60 Dose (“MED) and is defined as the threshold dose that can have properties ranging from Soft and weak to hard and produces skin erythema. The MED indicates the amount of tough and include, without limitation, Substantially dilute energy irradiating the skin and the responsiveness of the skin cross-linked system, which exhibit no flow when in a to the radiation. In order to determine the MED, the reaction steady-state. In an embodiment a gel includes, without of the skin is recorded 24 hours after exposure to UV limitation, a hydrogel an organogel or a Xerogel. 65 radiation. The minimal dose that induces any visible red In an embodiment, a conditioner includes, without limi dening at that point is defined as one MED. Redness that tation, hair conditioner, which can include, without limita occurs immediately after exposure, however, and disappears US 9,456,967 B2 11 12 during the following three to five hours is mainly caused by (ethyl, isobutyl, glyceryl esters; p-dimethylaminobenzoic heat and is not comparable with real UV erythema. acid); Anthranilates (i.e., o-aminobenzoates; methyl, men In an embodiment, “average SPF is the SPF, determined thyl, phenyl, benzyl, phenylethyl, linallyl, terpinyl, and as described herein, for about 5 to about 50 subjects, or cyclohexenyl esters); Salicylates (amyl, phenyl, benzyl, about 5 to about 20 subjects, or about 5 to about 10 subjects, 5 menthyl, glyceryl, and dipropylene glycol esters); Cinnamic where the subjects preferably have Type II skin. The SPF of acid derivatives (methyl and benzyl esters, alpha-phenyl a particular Sunscreen active agent is obtained by dividing cinnamonitrile; butyl cinnamoyl pyruvate); Dihydroxycin the MED of skin that has been protected by an active agent namic acid derivatives (umbelliferone, methylumbellifer by the MED of unprotected skin. The higher the SPF, the one, methylaceto-umbelliferone); Trihydroxycinnamic acid more effective the active agent is in preventing an individual 10 derivatives (esculetin, methylesculetin, daphnetin, and the from skin erythema, which is on an individual is recognized glucosides, esculin and daphnin); Hydrocarbons (diphenylb as constituting a Sunburn. SPF is generally measured in utadiene, stilbene); Dibenzalacetone and benzalacetophe numerical increments that identify how long an individual none; Naphtholsulfonates (sodium salts of 2-naphthol-3.3- can be exposed to UV radiation from the sun before that disulfonic and of 2-naphthol-6,8-disulfonic acids); same individual will experience 1 MED. For example, 15 Dihydroxynaphthoic acid and its salts; o- and p-Hydroxy utilizing a sunscreen with an SPF of 6 will allow an biphenyldisulfonates; Coumarin derivatives (7-hydroxy, individual to be exposed to the Sun six times longer than an 7-methyl, 3-phenyl); Diazoles (2-acetyl-3-bromoindazole, SPF of 1 before that individual receives 1 MED. As the SPF phenyl benzoxazole, methyl naphthoxalole, various aryl value of a Sunscreen increases, the less chance exists for benzothiazoles); Quinine salts (bisulfate, sulfate, chloride, development UV erythema of the skin. In an embodiment, a oleate, and tannate); quinoline derivatives (8-hydroxyqui Sunscreen product containing an Sunscreen active agent has noline salts, 2-phenylduinoline); Hydroxy- or methoxy Sub an SPF value ranging from about 2 to 70. Methods for stituted benzophenones; Uric and vilouric acids; Tannnic measuring SPF are described in, e.g., FDA monograph acid and its derivatives (e.g., hexaethylether): (Butyl carbi C.F.R. 21. A method for applying the sunscreen prior to tyl) (6-propyl piperonyl) ether, Hydroquinone; BenZophe measurement is as follows: Wet 50 cm square area of 25 nones (Oxybenzene, Sulisobenzone, Dioxybenzone, Benzo testing site with 10 ml of water delivered with a syringe. resorcinol, 2.2',4,4'-Tetrahydroxybenzophenone, 2,2'- Apply test sample as per FDA monograph to area. Work Dihydroxy4,4'-dimethoxybenzophenone, Octabenzone; lather on the subject for 3 minutes to allow the product to 4-Isopropyldibenzoylmethane; Butylmethoxydibenzoyl absorb into the skin. Rinse area after 2 additional minutes methane; Etocrylene; and 4-isopropyl-dibenzoylmethane; with 20 ml of water. Pat dry and allow 15 minutes before 30 titanium dioxide, iron oxide, Zinc oxide, and mixtures exposure to radiation as per FDA monograph. thereof. Other cosmetically-acceptable Sunscreens and con Log P is a term known to those of skill in the chemical centrations (percent by weight of the total cosmetic Sun arts. It is a measure of differential solubility of a compound screen composition) include diethanolamine methoxycinna in two solvents. More particularly, it is a partition coefficient mate (10% or less), ethyl-bis(hydroxypropyl) expressed as the log ratio of the concentrations of the solute 35 aminobenzoate (5% or less), glyceryl aminobenzoate (3% or in the solvent. A partition coefficient well known to persons less), 4-isopropyl dibenzoylmethane (5% or less), 4-meth having ordinary skill in the art is based on the solvents ylbenzylidene camphor (6% or less), terephthalylidene Octanol and Water. In an embodiment, a sunscreen active dicamphor sulfonic acid (10% or less), and sulisobenzone agent has a log P of greater than about 4.0 that blocks or (also called benzophenone-4, 10% or less). In an embodi absorbs ultraviolet radiation in the wavelength range of from 40 ment, Sunscreen active agents are FDA-approved or about 290 nm to about 400 nm and is selected from the group approved for use in the European Union. For example, consisting of octylmethoxycinnamate, octocrylene and octyl FDA-approved Sunscreen active agents may be used, singly salicylate. The at least one organic Sunscreen agent having or, preferably, in combination. See, e.g., U.S. Pat. Nos. a log P of greater than about 4 that blocks or absorbs 5,169,624; 5,543,136; 5,849,273; 5,904,917; 6,224,852; ultraviolet radiation in the wavelength range of from about 45 6.217.852; and Segarin et al., chapter Vil, pages 189 of 290 nm to about 400 nm includes sunscreens currently Cosmetics Science and Technology, and Final Over-the approved by the FDA and listed in the Sunscreen Drug Counter Drug Products Monograph on Sunscreens (Federal Products for Over-The-Counter Human Use Final Mono Register, 1999:64:27666 27963), all of which are incorpo graph published in the Federal Register on May 21, 1999 at rated herein by reference. Volume 64, Number 98, pages 27666-27693 as well as 50 In an embodiment, Zinc oxide is used as a Sunscreen organic Sunscreen active agents approved by regulatory active agent and the fine particle size of the Zinc oxide is in agencies in countries other than the United States. the range from 2 to 50 microns. In a further embodiment, the Any Sunscreen active agent known in the art or apparent Zinc oxide is, without limitation, at least about 2, 3, 4, 5, 6, to the skilled artisan may be used in the invention. The term 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, Sunscreen active agent as used herein defines ultraviolet 55 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, ray-blocking compounds exhibiting absorption or blockage 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50 or more microns. within the wavelength region between about 290 and 420 In a further embodiment, Zinc oxide can, without limitation, nm. Sunscreen active agents may be classified, without be surface coated to facilitate dispersion. limitation, into five groups based upon their chemical struc In an embodiment, a product marketed in the United ture: paraamino benzoates; Salicylates; cinnamates; benzo 60 States, preferred cosmetically-acceptable Sunscreen active phenones; and miscellaneous chemicals including menthyl agents and concentrations (reported as a percentage by anthralinate and digalloyl trioleate. Inorganic Sunscreen weight of the total cosmetic Sunscreen composition, and active agents may also be used including titanium dioxide, referring to the final percentage of the Sunscreen active agent Zinc oxide, iron oxide and polymer particles such as those of after addition to the bodywash) include: aminobenzoic acid polyethylene and polyamides. 65 (also called para-aminobenzoic acid and PABA; 15% or less; Specific Suitable Sunscreen active agents include, for a UVB absorbing organic Sunscreen), avobenzone (also example: p-aminobenzoic acid, its salts and its derivatives called butyl methoxy dibenzoylmethane; 3% or less, a UVA US 9,456,967 B2 13 14 I absorbing organic Sunscreen), cinoxate (also called chromophores. In an embodiment, the silicon long-chain 2-ethoxyethyl p-methoxycinnamate; 3% or less, a UVB molecule may be used in Sunscreen active agents at about absorbing organic Sunscreen), decamsule, dioxybenzone 0.5 to about 5%, or in a combination product comprising one (also called benzophenone-8; 3% or less, a UVB and UVA or more Sunscreen active agents and a bodywash, shampoos, II absorbing organic Sunscreen), homosalate (15% or less, a lotion, conditioner, gel, Soap, hand sanitizer, cream, or spray UVB absorbing organic Sunscreen), menthyl anthranilate at a concentration of about 0.2 to about 2% (w/v). (also called menthyl 2-aminobenzoate; 5% or less, a UVA II In an embodiment, inorganic physical blockers of UVA absorbing organic Sunscreen), octocrylene (also called and UVB include, without limitation, iron oxide and poly 2-ethylhexyl-2-cyano-3.3 diphenylacrylate; 10% or less, a mer particles such as those of polyethylene and polyamides. UVB absorbing organic Sunscreen), octyl methoxycinna 10 In further embodiments, a Sunscreen active agent is, without mate (7.5% or less, a UVB absorbing organic sunscreen), limitation, cinnamate (e.g., Octylmethoxycinnamate (ethyl octyl salicylate (also called 2-ethylhexyl salicylate; 5% or hexyl methoxycinnamate), (available under the tradename less, a UVB absorbing organic Sunscreen), oxybenzone (also PARSOL MCX), oxybenzone (e.g., benzophenone-3 (2-Hy called benzophenone-3; 6% or less, a UVB and UVA II droxy4-Methoxybenzophenone), avobenzone (4-tert-Butyl absorbing organic Sunscreen), padimate 0 (also called octyl 15 4'-methoxydibenzoylmethane or PARSOL 1789), octyl dimethyl PABA; 8% or less, a UVB absorbing organic salicylate (2-Ethylhexyl Salicylate), octocrylene (2-Ethyl Sunscreen), phenylbenzimidazole Sulfonic acid (water hexyl 2-Cyano-3,3-Diphenylacrylate), methyl anthranilate, soluble; 4% or less, a UVB absorbing organic sunscreen), and/or titanium dioxide, or combinations thereof. Sulisobenzone (also called benzophenone-4; 10% or less, a In an embodiment, a p-methoxycinnamic acid ester first UVB and UVA II absorbing organic sunscreen), titanium Sunscreen active agent includes, without limitation, amyl dioxide (25% or less, an inorganic physical blocker of UVA p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate, and UVB), trolamine salicylate (also called triethanolamine 2-ethoxyethyl p-methoxycinnamate, diethanolamine salicylate: 12% or less, a UVB absorbing organic sun p-methoxycinnamate, n-octyl p-methoxycinnamate and pro screen), Zinc oxide (25% or less, an inorganic physical pyl p-methoxycinnamate. blocker of UVA and UVB) and Tineubin (a UVA absorber 25 In an embodiment, a second Sunscreen active agent rec manufactured by BASF). ognized as safe and effective by the US Food and Drug In an embodiment, in the European Union, preferred Administration includes, without limitation, p-aminoben cosmetically-acceptable photoactive Sunscreen active agents Zoic acid, Cinoxate, AVobenzone, digalloyl trioleate, dioxy and concentrations (reported as a percentage by weight of benZone, ethyl 4-bis(hydroxypropyl)aminobenzoate, glyc the total cosmetic Sunscreen composition, and referring to 30 eryl aminobenzoate, homosalate, lawsone with the final percentage of the Sunscreen active agent after dihydroxyacetone, menthyl anthranilate, octocrylene ethyl addition to the bodywash) include: PABA (5% or less), 2-cyano-3,3-diphenyl acrylate, octyl salicylate, oxybenzone, camphor benzalkonium methosulfate (6% or less), homo Padimate O. phenylbenzimidazole sulfonic acid, red petro salate (10% or less), benzophenone-3 (10% or less), phe latum, Sulisobenzone, titanium dioxide, Zinc oxide, includ nylbenzimidazole sulfonic acid (8% or less, expressed as 35 ing regular grades and grades of Such fine particle size as acid), terephthalidenedicamphor sulfonic acid (10% or less, enable the composition to be translucent or transparent, and expressed as acid), butyl methoxydibenzoylmethane (5% or triethanolamine salicylate. Additional Sunscreen compounds less), Mexoryl XL, Neo heliopan AP, Benzophenone-9, recognized by European authorities include N.N.N-trim Uvinul T 150, Uvinul A Plus, Uvasorb HEB, Parsol SLX, ethyl-4-(2-oxoborn-3-ylidene methyl)anilinium methyl sul benzylidene camphor Sulfonic acid (6% or less, expressed as 40 fate, 3-imidazol-4-ylacrylic acid and its ethyl ester, 2-phe acid), octocrylene (10% or less, expressed as acid), poly nylbenzimidazole-5-sulfonic acid and its salts, ethoxylated acrylamidomethylbenzylidene camphor (6% or less), octyl 4-aminobenzoic acid, amyl 4-dimethylaminobenzoate, 3.3, methoxycinnamate (10% or less), PEG-25 PABA (10% or 5-trimethylcyclohexyl-2-acetamidobenzoate, potassium cin less), isoamyl p-methoxycinnamate (10% or less), ethyl namate, 4-methoxycinnamic acid salts, propyl 4-methoxy hexyl triazone (5% or less), drometrizole trielloxane (15% or 45 cinnamate, Salicylic acid salts, amyl 4-methoxycinnamate, less), diethylhexylbutamido triazone (10% or less), 4-meth meXenone, Sulisobenzone, 2-ethylhexyl 2-(4-phenylben ylbenzylidene camphor (4% or less), 3-benzylidene cam Zoyl)-benzoate, 5-methyl-2-phenylbenzoxazole, sodium phor (2% or less), ethylhexyl salicylate (5% or less), ethyl 3,4-dimethoxyphenylglyoxylate, 1,3-bis(4-methoxyphenyl) hexyl dimethyl PABA (8% or less), benzophenone-4 (5%, propane-1,3-dione, 5-(3.3-dimethyl-2-norbornylidene)-3- expressed as acid), methylene bis-benztriazolyl tetrameth 50 penten-2-one, alpha-(2-oxoborn-3-ylidene)-p-Xylene-2-sul ylbutylphenol (10% or less), disodium phenyl dibenzimida fonic acid, alpha-(2-oxoborn-3-ylidene)toluene-4-Sulfonic Zole tetrasulfonate (10% or less, expressed as acid), bis acid and its salts, 3-(4-methylbenzylidene)bornan-2-one, ethylhexyloxyphenol methoxyphenol triazine (10% or less), 3-benzylidenebornan-2-one, alpha-cyano-4-methoxycin methylene bisbenzotriazolyl tetramethylbutylphenol (10% namic acid and its hexyl ester, 1-p-cumenyl-3-phenylpro or less, also called TINOSORBM), and bisethylhexyloxy 55 pane-1.-3-dione, 4-isopropylbenzyl salicylate, cyclohexyl phenol methoxyphenyl triazine. (10% or less, also called 4-methoxycinnamate, and 1-(4-t-butylphenyl)-3-(4- TINOSORBS). methoxyphenyl)propane-1,3-dione. In further embodiments, the Sunscreen active agent In an embodiment, a Sunscreen active agent includes, includes, without limitation, a silicone long-chain molecule without limitation, octyl methoxycinnamate at about 4.5 to with chromophores, e.g., PARASOL SLX (DSM Nutritional 60 about 9%, Octocrylene at about 0.5 to about 15%, Avoben Products), which contains benzyl malonate chromophores Zone (e.g., PARSOL 1789) at about 2 to about 4%, and attached to specific points on a polysiloxane chain. In an titanium dioxide at about 3 to about 9%. additional embodiment, a Sunscreen active agent comprises In an embodiment, a Sunscreen composition includes, a silicone long-chain molecule with chromophores. In an without limitation, about 0.1 to 7.5 weight percent of octyl embodiment, Sunscreen compositions include, without limi 65 methoxy cinnamate, about 0.1 to 6 parts weight percent of tation, octyl methoxycinnamate, octocrylene, avobenzone, octyl salicylate, about 0.1 to 5 parts weight percent of titanium dioxide, and a silicone long-chain molecule with oxybenzone, about 1 to 10 weight percent of cationic US 9,456,967 B2 15 16 Surfactant, and about 0.01 to 1 weight percent of a quater 75, 76, 77, 78, 79,80, 81, 82, 83, 84, 85, 86, 87, 88, 89,90, nized compound. These Sunscreen compositions may further 91, 92, 93, 94, 95, 96, 97, 98, 99, 100 or more. In an include, without limitation, a film former and/or 0.01 to 1 embodiment, the average SPF after rinsing is above about 2, weight percent of a preservative. above about 5, above about 10, above about 15, In an In an embodiment, a composition containing a Sunscreen 5 embodiment, the average SPF provided by a composition active agent provides protection from the sun's UV radiation containing a Sunscreen active agent, after rinsing, remains after application on average, by greater than an SPF of 1 and above about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, up to about SPF 70. In a further embodiment, the average 16, 17, 18, 19, or 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, SPF provided by a composition containing a Sunscreen 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, active agent is about 1 to about 50, or about 2 to about 50, 10 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, or about 2 to about 40, or about 2 to about 30, or about 2 to 63, 64, 65,66, 67, 68, 69, 70, 71, 72, 73,74, 75, 76, 77, 78, about 20, or about 2 to about 10, or about 2 to about 5, or 79, 80, 81, 82, 83, 84,85, 86, 87, 88, 89,90,91, 92,93, 94, about 5 to about 25, or about 5 to about 20, or about 5 to 95, 96, 97,98, 99, 100 or more, for an average of at least about 15, or about 5 to about 10. In an additional embodi about 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, ment, the average SPF provided by a composition contain 15 17, 18, 19, 20, 21, 22, 23, 24, 25, 30, 35, 40, 45, 50, 55, 60, ing a Sunscreen active agent is at least 1, 2, 3, 4, 5, 6, 7, 8, 65, 70, 75, 80, 85, 90, 95, 100 hours or more or for an 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, average, of at least about 1 day, 2 days, 3 days, 4 days, 5 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, days, 6 days, 7 days, 8 days, 9 days, 10 days, 11 days, 12 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, days, 13 days, 14 days, after rinsing. In an embodiment the 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, average SPF provided by a composition containing a Sun 73, 74, 75, 76, 77, 78, 79,80, 81, 82, 83, 84, 85, 86, 87, 88, screen active agent increases with each additional washing 89, 90,91, 92,93, 94, 95, 96, 97,98, 99, 100 or more. In an after a first wash, and a Subsequent rinse, so that after a embodiment, the average SPF is above about 2, above about second, third, fourth, fifth, sixth, seventh, eighth, ninth, 5, above about 10, above about 15. In an embodiment, the tenth, eleventh or more washes, the SPF provided can be average SPF provided by a composition containing a Sun 25 above about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, screen active agent remains at least 1, 2, 3, 4, 5, 6, 7, 8, 9. 16, 17, 18, 19, or 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20, 21, 22, 23, 24, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 63, 64, 65,66, 67, 68, 69, 70, 71, 72, 73,74, 75, 76, 77, 78, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 30 79, 80, 81, 82, 83, 84,85, 86, 87, 88, 89,90,91, 92,93, 94, 73, 74, 75, 76, 77, 78, 79,80, 81, 82, 83, 84, 85, 86, 87, 88, 95, 96, 97,98, 99, 100 or more. 89, 90,91, 92,93, 94, 95, 96, 97,98, 99, 100 or more, for In an embodiment, after application of a composition an average of at least about 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10. containing a Sunscreen active agent to the skin followed by 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 30, rinsing, the Sunscreen active agent penetrates to an average 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85,90, 95, 100 hours 35 of at least about 5 microns beneath the skin surface. In an or more or for an average, of at least about 1 day, 2 days, 3 embodiment, the Sunscreen active agent penetrates to an days, 4 days, 5 days, 6 days, 7 days, 8 days, 9 days, 10 days, average of at least about 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 11 days, 12 days, 13 days, 14 days, after rinsing. In an 55, 60, 65, 70, 75, 80, 85,90, 95, 100, 105, 110, 115, 120, embodiment the average SPF provided by a composition 125, 130, 135, 140, 145 or 150 microns beneath the skin containing a Sunscreen active agent increases with each 40 surface. In a further embodiment, after application of a body additional washing after a first wash, so that after a second, wash, shampoo, conditioner, gel, Soap, hand sanitizer, third, fourth, fifth, sixth, seventh, eighth, ninth, tenth, elev cream, spray, mousse and/or and lotion containing Sunscreen enth or more washes, the SPF provided can be at least 1, 2, active agent to the skin and/or hair followed by rinsing, the 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or Sunscreen active agent penetrates to an average of no more 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 45 than about 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 70, 75, 80, 85, 90, 95, 100, 105, 110, 115, 120, 125, 130, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 135, 140, 145 or 150 microns beneath the skin surface. In an 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, additional embodiment, after application of the body wash, 84, 85, 86, 87, 88, 89,90,91, 92,93, 94, 95, 96, 97,98, 99, shampoo, conditioner, gel, Soap, hand sanitizer, cream, 100 or more. 50 spray, mousse and/or and lotion containing an active agent In an embodiment, a composition containing a Sunscreen to the skin followed by rinsing, the active agent penetrates active agent provides protection from the sun's UV radiation to an average of about 5 to about 150, 5 to about 140, to after application on average, and after rinsing, by greater about 5 to about 130, 5 to about 120, 5 to about 110, 5 to than an SPF of 1 and up to about SPF 70. In a further about 100, 5 to about 90, 5 to about 80, 5 to about 70, 5 to embodiment, the average SPF provided by a composition 55 about 60, 5 to about 50, 5 to about 40, 5 to about 30, 5 to containing a Sunscreen active agent after rinsing is about 1 about 20, 5 to about 10, 10 to about 20, 10 to about 30, 10 to about 50, or about 2 to about 50, or about 2 to about 40, to about 40, 10 to about 50, 10 to about 60, 10 to about 70, or about 2 to about 30, or about 2 to about 20, or about 2 to 10 to about 80, 10 to about 90, 10 to about 100, 20 to about about 10, or about 2 to about 5, or about 5 to about 25, or 30, 20 to about 40, 20 to about 50, 20 to about 60, 20 to about about 5 to about 20, or about 5 to about 15, or about 5 to 60 70, 20 to about 80, 20 to about 90, 20 to about 100, 30 to about 10. In an additional embodiment, the average SPF about 40, 30 to about 50, 30 to about 60, 30 to about 70, 30 provided by a composition containing a Sunscreen active to about 80, 30 to about 90, 30 to about 100, 40 to about 50, agent, after rinsing, is above about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10. 40 to about 60, 40 to about 70, 40 to about 80, 40 to about 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 90, 40 to about 100, 50 to about 60, 50 to about 70, 50 to 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,38, 39, 40, 41, 42, 65 about 80, 50 to about 90, 50 to about 100, 60 to about 70, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 60 to about 80, 60 to about 90, 60 to about 100, 70 to about 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 80, 70 to about 90, 70 to about 100, 80 to about 90, 80 to US 9,456,967 B2 17 18 about 100 or 90 to about 100, or about 5, 10, 15, 20, 25, 30, applicator. In a further embodiment, the applicator is a 25, 40, 45, or 50 microns beneath the skin surface. Depth of Squeezable bottle wherein the Sunscreen composition can be penetration may be tested by tape stripping methods that are removed from the bottle as an individual squeezes the bottle. well-known in the art. In an embodiment, the Sunscreen composition containing a In an embodiment, a Sunscreen composition containing a Sunscreen active agent is applied using a spray on applicator, Sunscreen active agent contains at least one Sunscreen active including, without limitation, a spray bottle. agent. In a further embodiment, a Sunscreen composition In an embodiment, the Sunscreen composition containing containing a Sunscreen active agent contains one, two, three, a Sunscreen active agent is a powder or other dry form. In a four, or more different Sunscreen active agent. In an embodi further embodiment, the Sunscreen composition containing a ment, a composition containing a Sunscreen active agent 10 Sunscreen active agent is applied to an individual by apply contains three different Sunscreen active agents. In a further ing the powder or other dry form to the individual. In a embodiment, a composition containing a Sunscreen active further embodiment, following application of the powder or agent contains four, five or six different Sunscreen active other dry form, the Sunscreen composition containing a agents. The Sunscreen active agent may be an organic Sunscreen active agent is rubbed, massaged, caressed onto molecule or inorganic. The Sunscreen active agent may be a 15 the individual. In an embodiment, the Sunscreen composi UVA absorber, a UVB absorber, a physical blocker, a tion containing a Sunscreen active agent that is in the form physical reflector, or any combination thereof. In an embodi of a powder or other dry form is stored in an applicator. In ment, one or more of the Sunscreen active agents is encap an embodiment, the applicator is the same as the applicator Sulated in a cellulose capsule. In an embodiment, a compo used for powder or other dry form products, including, sition containing a Sunscreen active agent may include, without limitation, a baby powder bottle or other applicator without limitation, one or more other additional agents. In a that is conformed to the application of a powder or other dry further embodiment, the additional agents are included in a form of a Sunscreen composition. Sunscreen composition that contains one or more Sunscreen In an embodiment, the Sunscreen active agents of the active agents. In a further embodiment, the additional agents invention can be, without limitation, combined with a con can be, without limitation, one or more components capable 25 ventional bodywash, shampoo, lotion, spray, conditioner, of providing a positive charge to the system to assist with gel, Soap, hand sanitizer, cream, or mousse. The bodywash, attachment to a negatively charged molecule or Surface. Such shampoo, lotion, spray, conditioner, gel, Soap, hand sani as, without limitation, charged components of skin and/or tizer, cream, or mousse can be, without limitation, any hair. In an embodiment, the cationic polymer is, without bodywash, shampoo, lotion, spray, conditioner, gel, Soap, limitation, a quaternium, e.g., polyguarternium. The addi 30 hand sanitizer, cream or mousse known in the art or apparent tional agents can be, without limitation, a film former, to one of skill in the art, as described above. In a further including, without limitation, dimethicone and/or petrola embodiment, the invention provides a sunscreen composi tum, and/or a preservative, such as BHT. In a further tion containing at least one or more Sunscreen active agents embodiment, other additional agents, that can be added to a in combination with one or more surfactants. The Sunscreen formulation, but are not necessarily required, 35 Surfactant(s) may be cationic, anionic, nonionic, Zwitteri include, without limitation, preservatives, antioxidants, onic, amphoteric, or any combination thereof. In an embodi chelating agents, liquid hydrocarbon (e.g., one similar to ment, the bodywash, shampoo, lotion, spray, conditioner, pentane), foaming agents (e.g., a cationic foaming agent), gel, Soap, hand sanitizer, cream or mousse contains at least skin nourishing components, antibacterials, medicinals, and one Sunscreen active agent that is organic or inorganic, or a the like. 40 combination of both. In an embodiment, Sunscreen compo In an embodiment, the Sunscreen composition containing sitions include UV absorbers, blockers (e.g., many inorganic a Sunscreen active agent is applied topically to the skin of an sunscreens are UV blockers) or reflectors. UV absorbers individual. In a further embodiment, the Sunscreen compo may be a UVB or UVA absorber (e.g., UVA I or UVA II sition containing a Sunscreen active agent is applied to the absorber). In a further embodiment, a Sunscreen active agent hair or sprayed onto the skin or hair of an individual. In an 45 includes, without limitation, more than one organic Sun additional embodiment, the Sunscreen composition contain screen active agent (e.g., at least one UVB absorber and at ing a Sunscreen active agent that is applied topically or least one UVA absorber) and at least one inorganic Sunscreen sprayed onto the hair or skin of an individual contains, active agent. In an embodiment, a Sunscreen active agent is without limitation, at least one additional agent. a physical blocker Sunscreen, e.g., titanium dioxide. In an In an embodiment, the Sunscreen composition containing 50 additional embodiment, a Sunscreen active agent is, without a Sunscreen active agent is applied to an individual with an limitation, a cationic polymer and/or a film former as well as applicator, including, without limitation, with a sponge, a any other components described herein for Sunscreen active loofah, a toy, a cotton pad, a wash cloth, a specialized wash agents. Additional ingredients may include film formers, cloth, a towel, clothing, a spray bottle, an applicator bottle cationic polymers, antioxidants, preservatives, and the like. or any device or article, including a clothing article or 55 In an embodiment, a Sunscreen composition is used, applicator. In a further embodiment, a toy, includes, without without limitation, to treat an individual suffering from, limitation, a rubber Squeeze toy, including, without limita Seborrheic dermatitis, eczema, Xerosis, infestation, dyschro tion, a rubber duck, or a plastic Squeeze toy. In an embodi mia, keratosis pilaris, acne, anti-aging, sensitive skin, ephi ment, the applicator is preloaded or can be loaded with the lidies, Solar lentigines, photo sensitive disease, skin cancer Sunscreen composition containing a Sunscreen active agent. 60 and hX of skin cancer, melisma, auto immune, alopecia, In an embodiment, the application, includes, without limi fungal, bacterial, and viral infections, protect colored or tation, an applicator bottle with a roller ball, a push button, treated hair, bromhidrosis, malodor, dandruff, wound heal a nozzle, a turn nob or other means to apply the Sunscreen ing, insect repellant, pet shampoofskin care, lindane or composition to an individual. In a further embodiment, the similar conditions. applicator provides the Sunscreen composition to an indi 65 In an embodiment, a Sunscreen composition can contain vidual in metered, defined amounts. In an embodiment, the as a Sunscreen active agent only titanium dioxide. Titanium metering is by pushing down on a nozzle that is part of the dioxide, either alone or in combination with other Sun US 9,456,967 B2 19 20 screens, can have an anatase, rutile, or amorphous structure. 46, 47, 48, 49, 50% or more of the sunscreen composition Titanium dioxide particles can be uncoated or can be coated (all percentages herein are weight per Volume percent unless with a variety of materials including, without limitation, otherwise specified). In an embodiment, a combination of aluminum compounds such as aluminum oxide, aluminum one or more Sunscreen active agents and a bodywash, Stearate, aluminum laurate and the like; phospholipids Such shampoo, lotion, mousse, conditioner, gel, Soap, hand sani as lecithin; silicone compounds; and mixtures thereof. Vari tizer, cream, or spray, the one or more Sunscreen active ous grades and forms of titanium dioxide are described in agents comprise at least about 0.05, 1.5, 2.5, 7.5, 1, 2, 3, 4, CTFA Cosmetic Ingredient Dictionary. Third Edition 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, (1982), pp. 318 319; U.S. Pat. No. 4,820,508 to Wortzman, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, issued Apr. 11, 1989; and World Patent No. WO 90/11067 to 10 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or, or more than Elsom et al, published Oct. 4, 1990; these three references 50% of the sunscreen composition. are incorporated by reference herein in their entirety. Suit In an embodiment, a Sunscreen composition absorbs at able grades of titanium dioxide for use in a Sunscreen least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, composition can be purchased from commercial Suppliers, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, including, without limitation, the MT micronized series 15 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, from Tri-K Industries (Emerson, N.J.). Micronized titanium 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, dioxides generally have a mean primary particle size ranging 67, 68, 69, 70, 71, 72,73, 74, 75, 76, 77, 78, 79,80, 81, 82, from about 10 nm to about 50 nm. For example, the titanium 83, 84,85, 86, 87, 88, 89,90,91, 92,93, 94, 95, 96, 97,98, dioxide has a mean primary particle size of about 15 nm and 99, or 100% of incident radiation at wave lengths of 290 to this Sunscreen active agent is available under the trade 320 nanometers. In a further embodiment, a Sunscreen designation MT-15OW (uncoated) and MT-100T (coated composition absorbs at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, with Stearic acid and aluminum compounds). Uncoated 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, titanium dioxides having mean primary particle sizes of 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,38, 39, 40, 41, 42, 43, around 35 nm and around 50 nm are available under the 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, trade designations MT-500B and MT-600B, respectively. 25 60, 61, 62, 63, 64, 65, 67, 68, 69, 70, 71, 72,73, 74, 75, 76, Other coated titanium dioxides having a mean primary 77,78, 79,80, 81, 82, 83, 84,85, 86, 87, 88, 89,90,91, 92, particle size around 15 nm include MT-100F (modified with 93, 94, 95, 96, 97, 98, 99, or 100% of incident radiation at stearic acid and iron hydroxide) and MT-100S (treated with wave lengths less than 290 or greater than 320 nanometers. lauric acid and aluminum hydroxide). Mixtures of two or In an embodiment, a Sunscreen composition is combined more types and particle size variations of titanium dioxide 30 with a bodywash, shampoo, lotion, conditioner, gel, Soap, can be used in the present invention. In an embodiment the hand sanitizer, cream, spray or moussein a ratio of about one titanium dioxide is a silica-coated titanium dioxide, includ part sunscreen active agent to two parts bodywash, sham ing, without limitation T-AVO (Eusolex). poo, lotion, conditioner, gel, Soap, hand sanitizer, cream, In an embodiment, a Sunscreen composition contains a spray or mousse measured as w/w. In a further embodiment, Zinc based sunscreen active agent (e.g., Z-COTETM HP 1 35 the ratio of Sunscreen composition to bodywash, shampoo, registered trademark, SkinCeuticals). Zinc Sunscreen lotion, conditioner, gel, Soap, hand sanitizer, cream, spray or active agent can be, without limitation, a micro-fine Zinc mousse is, without limitation, about 0.2,0.5, 0.7 1.0, 1.1, oxide coated with a form of dimethicone that transforms the 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, frequently granular and pasty particles of Zinc oxide to a 2.6, 2.7, 2.8, 2.9, 3.0, 3.2, 3.5, 3.7, 4.0, 4.2, 4.5, 4.7, 5.0, 6.0, Smooth formulation which is transparent and does not give 40 7.0, 8.0, 9.0, 10; 12, 15, or 20 parts bodywash, shampoo, the appearance of skin coated with white paint. lotion, conditioner, gel, Soap, hand sanitizer, cream, spray or In a further embodiment, inorganic Sunscreen active mousse to Sunscreen active agent as measured w/w. agents are, without limitation, Tioveil and Spectraveil (both In an embodiment, the Sunscreen composition has a pH of of the Tioxide Group). Tioveil include, without limitation, about 6 to about 8. In a further embodiment, the sunscreen products which are 40% dispersions of surface-treated tita 45 composition has a pH of about 6.7 to about 7.5. In a further nium dioxide in a range of cosmetic Vehicles. Spectraveil embodiment, the Sunscreen composition has a pH of at least include, without limitation, products which are 60% disper 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14. sions of Zinc oxide in a range of cosmetic vehicles. In an In an embodiment, a Sunscreen composition is combined embodiment, Tioveil and Spectraveil are film-formers. with a bodywash, shampoo, lotion, conditioner, gel, Soap, In an embodiment, a Sunscreen composition comprising 50 hand sanitizer, cream, spray or mousse all at once, in groups, one or more Sunscreen active agents is encapsulated. In a or separately. In an embodiment, a Sunscreen composition further, embodiment, a Sunscreen composition comprises comprises at least two separate components that include, one or more Sunscreen active agents and one or more without limitation, a first component that comprises all the additional agents that are encapsulated. Encapsulation ingredients except an inorganic or physical blocker Sun increases the stability of the Sunscreen composition as well 55 screen, and a second component that comprises an inorganic as increases the effectiveness of the Sunscreen composition or physical blocker Sunscreen active agent. In an embodi to protect an individual from deleterious effects suffered ment, a first component is added to a bodywash, shampoo, from exposure to the Sun's harmful rays. Encapsulation also lotion, conditioner, gel, Soap, hand sanitizer, cream, spray or can minimize their absorption of the Sunscreen active agent mousse with thorough mixing, followed by a second com into the dermis and its excretion in the urine. 60 ponent. In a further embodiment, all ingredients except the In an embodiment, a Sunscreen active agent comprises titanium dioxide are mixed, then added to a bodywash, about 0.1% to about 50%, or about 1% to about 30%, or shampoo, lotion, conditioner, gel, Soap, hand sanitizer, about 1% to about 25%, or about 3% to about 25%, or about cream, spray or mousse, and then the titanium dioxide is 5% to about 25%, or about 10% to about 25% or about 15% added. to about 25%, or about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 65 In an embodiment, a Sunscreen composition is encapsu 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, lated in a cellulose derived capsule. In a further embodi 30, 31, 32, 33, 34, 35, 36, 37,38, 39, 40, 41, 42, 43, 44, 45, ment, a Sunscreen composition is encapsulated in a cellulose US 9,456,967 B2 21 22 derived capsule and a second Sunscreen composition is not about 400 nm to about 650 nm, about 400 nm to about 600 encapsulated. In a further embodiment, a Sunscreen compo nm, about 400 nm to about 550 nm, about 400 nm to about sition contains cellulose derived capsules comprising more 500 nm, about 400 nm to about 450 nm, about 200 nm to than one cellulose derivative. In a further embodiment, the about 700 nm, about 250 nm to about 650 nm, about 300 nm. cellulose derived capsules in a Sunscreen composition are of 5 to about 600 nm, about 350 nm to about 550 nm. In a further different sizes and/or contain multiple layers. In an addi embodiment, 75% or more of the cellulose derived capsules tional embodiment, each layer of a cellulose derived capsule have a diameter of about 300 nm to about 600 nm. In a can contain one or more Sunscreen active agents and/or further embodiment, a cellulose derived capsule has a diam additional agents. eter of at least 25 nm, at least 50 nm, at least 75 nm, at least In an additional embodiment, one or more different Sun 10 100 nm, at least 125 nm, at least 150 nm, at least 175 nm, screen compositions are encapsulated in a cellulose derived at least 200 nm, at least 225 nm, at least 250 nm, at least 275 capsule and one or more Sunscreen compositions are not nm, at least 300 nm, at least 325 nm, at least 350 nm, at least encapsulated. Generally, encapsulation of a molecule, 375 nm, at least 400 nm, at least 425 nm, at least 450 nm, including, without limitation, a Sunscreen active agent or a at least 475 nm, at least 500 nm, at least 525 nm, at least 550 additional agent involves trapping the Sunscreen active agent 15 nm, at least 575 nm, at least 600 nm, at least 625 nm, at least or additional agent in, e.g., a vesicle. In an embodiment, 650 nm, at least 675 nm, at least 700 nm, at least 725 nm, depending on the vesicle of choice, the vesicle may remain at least 750 nm, at least 775 nm, at least 800 nm, at least 825 intact following application to an individual or it may break nm, at least 850 nm, at least 875 nm, at least 900 nm, at least open when applied. In a further embodiment, the vesicle 925 nm, at least 950 nm, at least 975 nm, at least 1000 nm. may break open when applied over a period of time, wherein O. O. the period of time can be continuous until the last vesicle In an embodiment, a Sunscreen composition includes, breaks open or at one or more defined period after applica without limitation, any one of any combination of or all of tion to an individual. In an embodiment, the stability, the following additional ingredients: water, a chelating durability, and/or SPF protection provided by a sunscreen agent, a moisturizing agent, a preservative, a thickening active agent in a bodywash, shampoo, conditioner, gel, Soap, 25 agent, a silicone containing compound, an essential oil, a hand sanitizer, cream, lotion, spray or mousse can be structuring agent, a vitamin, a pharmaceutical ingredient, or increased through the selection of a particular cellulose an antioxidant, or any combination of Such ingredients or derived capsule that meets the desired requirements. mixtures of Such ingredients. In an embodiment, the Sun In an embodiment, a cellulose derived capsule is a capsule screen composition includes, without limitation, at least two, wherein at least a portion of the capsule is composed of a 30 three, four, five, six, seven, eight, nine, ten, or all of these cellulose derivative. In a further embodiment, a cellulose additional ingredients identified in the previous sentence. In derived capsule includes, without limitation, a capsule a further embodiment, the amount of such ingredients can wherein the capsule is composed solely of a cellulose range from 0.0001% to 99.9% by weight or volume of the derivative. In a further embodiment, a cellulose derived composition, or any integer or range in between. In an capsule includes, without limitation, one or more anionic 35 embodiment, a Sunscreen composition includes, without components as part of the capsule. In a further embodiment, limitation, one or more of the aforementioned additional a cellulose derived capsule includes, without limitation, one ingredients, wherein the Sunscreen active agent is encapsu or more cationic components as part of the capsule. In a lated in a cellulose derived capsule and the additional further embodiment, a cellulose derived capsule includes, ingredients are not encapsulated in a cellulose derived without limitation one or more additional ingredients, 40 capsule. In a further embodiment, a Sunscreen composition including without limitation, a lipid, a dye, a therapeutic, a includes, without limitation, a Sunscreen agent encapsulated protein, an antimicrobial, an antibiotic or other molecule. In in a cellulose derived capsule and wherein one or more an embodiment, a capsule is a microcapsule, also known as additional ingredients are encapsulated in a cellulose derived a microsphere. In an additional embodiment, a cellulose capsule with the Sunscreen active agent or Sunscreen active derived capsule is flexible, can have high load rates and can 45 agents. be prepared in large quantities without a high reaction time In an embodiment, a Sunscreen composition or a Sun and drying step. The preparation and purification of cellu screen combination product, wherein a Sunscreen active lose derived capsules are well known in the art and available agent is encapsulated in a cellulose derived capsule for one of skill to prepare the cellulose derived capsules of increases the SPF protection of an individual on which a the present invention. In an embodiment, a cellulose derived 50 Sunscreen composition or a Sunscreen combination product capsule is photostable. In a further embodiment, a cellulose is applied as compared to a Sunscreen composition or a derived capsule is not photostable and without limitation, Sunscreen combination product where a Sunscreen active disintegrate following exposure to the Sun and release their agent is not encapsulated. In a further embodiment, a internal contents, including, a Sunscreen active agent and Sunscreen composition or a Sunscreen combination product, any additional agents included in the Sunscreen composition. 55 wherein a Sunscreen active agent is encapsulated in a In an embodiment, a cellulose derivative for use in a cellulose derived capsule increases the SPF protection of an cellulose derived capsule includes without limitation, individual on which a Sunscreen composition or a Sunscreen hydroxypropylcellulose, hydroxypropylmethylcellulose, combination product is applied as compared to a Sunscreen ethylcellulose and carboxymethylcellulose, and any deriva composition or a Sunscreen combination product where a tives therefrom. In an embodiment, the cellulose derivative 60 Sunscreen active agent is not encapsulated by at least 0.1 used in a cellulose derived capsule is hydroxypropylcellu times greater, 0.2 times greater, 0.3 times greater, 0.4 times lose. In a further embodiment the hydroxypropylcellulose greater, 0.5 times greater, 0.6 times greater, 0.7 times greater, has a medium or low degree of polymerization of the 0.8 times greater, 0.9 times greater, 1 times greater, 1.25 hydroxypropylcellulose. times greater, 1.5 times greater, 1.75 times greater, 2 times In an embodiment, a cellulose derived capsule has a 65 greater, 2.25 times greater, 2.5 times greater, 2.75 times diameter of about 400 nm to about 700 nm. In an additional greater, 3 times greater, 3.25 times greater, 3.5 times greater, embodiment, a cellulose derived capsule has a diameter of 3.75 times greater, 4 times greater, 4.25 times greater, 4.5 US 9,456,967 B2 23 24 times greater, 4.75 times greater, 5 times greater, 5.25 times 50, 55, 60, 65, 70, 75, 80, 85,90 or 95% to about 0.50.1, 0.5, greater, 5.5 times greater, 5.75 times greater, 6 times greater, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 6.25 times greater, 6.5 times greater, 6.75 times greater, 7 20, 21, 22, 23, 24, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, times greater, 7.25 times greater, 7.5 times greater, 7.75 80, 85, 90 or 95%, after application (or application and times greater, 8 times greater, 8.25 times greater, 8.5 times rinsing in the case of a bodywash, shampoo or conditioner, greater, 8.75 times greater, 9 times greater, 9.25 times gel, Soap, hand sanitizer, cream, containing the cellulose greater, 9.5 times greater, 9.75 times greater, 10 times derived capsules). In an embodiment, a cellulose derived greater, 11 times greater, 12 times greater, 13 times greater, capsule is formulated so as to break open in response to 14 times greater, 15 times greater, 16 times greater, 17 times conditions that occur on the skin, so that after application the greater, 18 times greater, 19 times greater, 20 times greater, 10 cellulose derived capsules act to release their contents in a 21 times greater, 22 times greater, 23 times greater, 24 times time-release or controlled manner. greater, 25 times greater, 30 times greater, 35 times greater, In an embodiment, additional agents that do not protect 40 times greater, 45 times greater, 50 times greater, 55 times against the Sun's radiation can be encapsulated in a cellulose greater, 60 times greater, 6.5 times greater, 70 times greater, derived capsule with or without a Sunscreen active agent. In 75 times greater, 80 times greater, 85 times greater, 90 times 15 an embodiment, additional agents that do not provide pro greater, 95 times greater, 100 times greater than a Sunscreen tection from the Sun's radiation are encapsulated in a cel agent is not encapsulated. lulose derived capsule that is added to a bodywash, sham In an embodiment, a cellulose derived capsule encapsu poo, conditioner, gel, Soap, hand sanitizer, cream, lotion, lated UVB absorber, for example, without limitation, octyl spray or mousse. In an additional embodiment, the cellulose methoxycinnamate, is used as a Sunscreen active agent at a derived capsule containing an additional agent, also contains concentration that results in a final concentration of the UVB a Sunscreen active agent. In an embodiment, a additional absorber in a shampoo, bodywash, conditioner, gel, Soap, agent that does not provide protection from the Sun's radia hand sanitizer, cream, lotion, spray or mousse of about 1% tion, includes, without limitation, Sunless tanning actives, to about 40%, or about 2% to about 20%, or about 2% to skin lightening actives, anti-acne actives, anti-skin wrin about 10%, or about 5% to about 10%, or about 1%, 2%, 3%, 25 kling and anti-skin aging actives, vitamins, anti-inflamma 4%, 5%, 6%, 7%, 7.4%, 7.5%, 7.6%, 8%, 9%, 10%, 11%, tory actives, anesthetic actives, analgesic actives, anti-pru 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, ritic actives, anti-microbial actives (e.g. antifungals, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, antibacterials, and antiparasitics), anti-virals, anti-allergen 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39% or 40%. In an ics, medicinal actives (e.g., skin rash, skin disease and embodiment the final concentration is about 7.6%. In an 30 dermatitis medications), anti-cellulite additives, insect repel embodiment, more than one Sunscreen active agent is encap lant actives, antioxidants, hair growth promoters, hair sulated in a cellulose derived encapsulate. In a further growth inhibitors, hair bleaching agents, vitamins, deodor embodiment, the final concentration of each of the Sunscreen ant compounds, or more. In a further embodiment, Sunless active agents, independently, in the final Sunscreen additive, tanning actives include, without limitation, dihydroxyac is about 1% to about 40%, or about 2% to about 20%, or 35 etone (DHA): glyceryl aldehyde; tyrosine and tyrosine about 2% to about 10%, or about 1%, 2%, 3%, 4%, 5%, 6%, derivatives such as malyltyrosine, tyrosine glucosinate, and 7%, 7.4%, 7.5%, 7.6%, 8%, 9%, 10%, 11%, 12%, 13%, ethyl tyrosine; phospho-DOPA, indoles and derivatives. In a 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, further embodiment, skin lightening actives include, without 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, limitation, EMBLICA (also an antioxidant), monobenzone 34%, 35%, 36%, 37%, 38%, 39% or 40%. The sunscreen 40 (a depigmenting agent), kojic acid, arbutin, ascorbic acid active agents may be encapsulated together or separately, or and derivatives thereof (e.g., magnesium ascorbyl phosphate any combination thereof. In an embodiment, a Sunscreen or Sodium ascorbyl phosphate), and extracts (e.g., mulberry active agent is added to a bodywash, shampoo, conditioner, extract, placental extract). In an additional embodiment, skin gel, Soap, hand sanitizer, cream, lotion, spray or mousse that lightening agents include, without limitation, those includes a Sunscreen active agent encapsulated in a cellulose 45 described in WO 95/34280, WO 95/07432, and WO derived capsule, including without limitation, a microcap 95/23780. Sule. In a further embodiment, the shampoo, conditioner, In an embodiment, vitamins include, without limitation, gel, Soap, hand sanitizer, cream, lotion, spray, mousse or Vitamin A and derivatives thereof (including, for example, bodywash containing an encapsulated Sunscreen active retinol, see anti-wrinkling actives), ascorbic acid (Vitamin C agent also contains, without limitation, a cationic polymer. 50 and derivatives), Vitamin B (e.g., riboflavin, vitamin B), In an additional embodiment, the shampoo, lotion, spray, biotin, Vitamin D (all forms), Vitamin E and derivatives mousse, bodywash or conditioner, gel, Soap, hand sanitizer, thereof Such as tocopheryl acetate, beta-carotene, panthoth cream, containing an encapsulated Sunscreen active agent enic acid and more. In a further embodiment, anti-acne can also contain, without limitation, a film former, an actives include, without limitation, benzoyl peroxide, eryth antioxidant, a preservative, a chelating agent, a thickener, an 55 romycin, clindamycin phosphate, 5,7-dichloro-8-hydroxy emollient, and/or other active and inactive ingredients. quinoline, resorcinol, resorcinol acetate, Salicylic acid, aza In an embodiment, an active Sunscreen agent is encapsu leic acid, long chain dicarboxylic acids, Sulfur, Zinc, various lated in a cellulosic derived capsule and wherein a Sunscreen natural agents such as those derived from green tree, and active agent includes, without limitation an inorganic mol more. Other non-limiting examples of Suitable anti-acne ecule. In a further embodiment, an inorganic Sunscreen 60 actives for use herein are described in U.S. Pat. No. 5,607, agent encapsulated in a cellulosic derived capsule includes, 980, which description is incorporated herein by reference. without limitation, titanium, zinc, metal alkoxides and more. In an embodiment, anti-skin wrinkling actives include, with In an embodiment, the cellulose derived capsules, includ out limitation, a variety of agents, often in combination, that ing without limitation, microcapsules, may be prepared so as prevent or treat Wrinkling through a variety of actions, to experience about 0% breakage, or breakage in a range 65 including, without limitation, cosmetic products that contain from about 0.1, 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, hydroxy acids, retinol, retinoic, retinol palmitate, a deriva 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 30, 35, 40, 45, tive of vitamin A, (or its stronger, prescribed version US 9,456,967 B2 25 26 Retin-A and Renova), bicyclic aromatic compounds with ylene, polyamides, polyethylene terephthalate, polyesters, retinoid-type activity, including, without limitation, those acrylonitrile butadiene styrene, polycarbonate, polyure described in EP 679 630. In an embodiment, antioxidants thane, polypropylene, melamine formaldehyde, phenolics, include, without limitation, Vitamin C. vitamin E and coen polyetheretherketone, polyetherimide, polylactic acid, Zyme Q-10. In a further embodiment, a additional agent can polymethyl methacrylate, polytetrafluoroethylene, urea include, without limitation, Botox (an extremely diluted formaldehyde, polystyrene, polyvinyl chloride and polytet form of botulinum toxin). rafluoroethylene. In an embodiment, a plastic can be biode In an embodiment, anti-skin aging or anti-wrinkling gradable or not. In a further embodiment, a plastic includes actives include, without limitation, bicyclic aromatic com vinyl or other plastics used in consumer products, including pounds, compounds which have retinoid-type activity, free 10 without limitation, automobiles, including, without limita radical scavengers, hydroxy or keto acids or derivatives tion, seats, dashboard, molding and/or trim. thereof. In a further embodiment, a “free-radical scavenger In an embodiment, Sunscreen composition that is encap includes, without limitation, C-tocopherol, Superoxide dis Sulated in a cellulose derived capsule are used in paints. In mutase, ubiquinol or certain metal-chelating agents. In an a further embodiment, a paint including an encapsulated additional embodiment, hydroxy acids include, without 15 Sunscreen composition includes one or more additional limitation, C.-hydroxy acids Such as lactic acid and glycolic agents, including, without limitation, HALS. acid or B-hydroxy acids such as Salicylic acid and Salicylic In an embodiment, a Sunscreen composition that is encap acid derivatives such as the octanoyl derivative; other Sulated in a cellulose derived capsule are used in products hydroxy acids and keto acids include, without limitation, used by the military, police or other governmental or non malic, citric, mandelic, tartaric or glyceric acids or the salts, governmental force. In an embodiment, a product used by amides or esters thereof. In a further embodiment, anti the by the military, police or other governmental or non wrinkling agents and anti-skin aging agents include, without governmental force includes, without limitation, Sunscreen, limitation, Sulfur-containing D and L amino acids and their paint, clothes, weapons, including, without limitation, weap derivatives and salts, particularly the N-acetyl derivatives, a ons containing composite or other synthetic parts, and other preferred example of which is N-acetyl-L-cysteine; thiols, 25 by the military, police or other governmental or non-gov e.g. ethane thiol: fat-soluble vitamins, ascorbyl palmitate, ernmental force products. In an embodiment, a Sunscreen ceramides, pseudoceramides (e.g., pseudoceramides composition that is encapsulated in a cellulose derived described in U.S. Pat. Nos. 5,198,210; 4,778,823: 4,985, capsule used for by the military, police or other governmen 547; 5,175.321, all of which are incorporated by reference tal or non-governmental force includes a reflective agent herein), phospholipids (e.g., distearoyl lecithin phospho 30 and/or an agent capable of preventing the detection of lipid), fatty acids, fatty alcohols, cholesterol, plant sterols, infrared radiation by an individual or equipment. phytic acid, lipoic acid; lysophosphatidic acid, and skin peel In an embodiment, cascading antioxidants include, with agents (e.g., phenol and the like), and mixtures thereof. In an out limitation, emblica and synovia. In an embodiment, embodiment, fatty acids and/or alcohols include, without quencher actives are used for singlet and triplet excited limitation, Straight or branched alkyl chains containing 12 35 electron stabilization caused from photons of energy and to 20 carbon atoms and linoleic acid. In a further embodiment, reduce or eliminate degradation. In an embodiment, anti-wrinkle actives include, without limitation, those quencher actives include, without limitation, electron recep described in U.S. Pat. No. 6,217,888, which description is tors, including, without limitation, Polycrylene. In an incorporated herein by reference. embodiment, an infrared reflective coating comprises an In an embodiment, skin whitening actives include, with 40 agent that reflects infrared radiation, for instance, without out limitation, skin lighteners and skin bleaching. In an limitation, at a wavelength between about 0.74 um to about embodiment, skin whitening actives include, without limi 300 Ln. In a further embodiment, an infrared reflective tation, hydroquinone, arbutin, koic acid, azelaic acid, Vita coating includes, without limitation, coatings which produce min c. cinnamomum subavenium, alpha hydroxyl acids different amounts of gloss and reflection. In a further ("AHA's), niacinamide and licorice extract (including, 45 embodiment, a Sunscreen composition with an infrared without limitation, glabridin). In an embodiment, skin whit reflective coating is used by a soldier, police, national guard, ening actives include depigmentation agents, including topi governmental agent, including, without limitation, an indi cal creams that contain the organic compound monobenzone vidual working for the Federal Bureau of Investigation, or the chemical meduinol. Alcohol, and Tobacco & Firearms, Secret Service, Central In an embodiment an additional agent is a hindered amine 50 Intelligence Agency, Department of Justice or any other light stabilizers, also referred to as “HALS. HALS are governmental agent, whether located in the United States or derivatives of 2.2.6,6-tetramethyl piperidine and are outside the United States or other individuals who requires extremely efficient stabilizers against light-induced degra an infrared reflective coating. dation of most polymers. HALS do not absorb UV radiation, In an embodiment, anti-inflammatory actives include, but act to inhibit degradation of the polymer. They slow 55 without limitation, steroidal, non-steroidal, and other com down the photochemically initiated degradation reactions, to pounds. In a further embodiment, Steroidal anti-inflamma Some extent in a similar way to antioxidants. In an embodi tory agents include, without limitation, corticosteroids Such ment, a significant level of Stabilization is achieved at as hydrocortisone, hydroxyltriamcinolone, alpha-methyl relatively low concentrations. dexamethasone, dexamethasone-phosphate, beclometha In an embodiment, Sunscreen composition that is encap 60 Sone dipropionates, clobetasol Valerate, desonide, des Sulated in a cellulose derived capsule are used in products oxymethasone, desoxycorticosterone acetate, dexametha exposed to the sun's UV radiation. In a further embodiment, Sone, dichlorisone, diflorasone diacetate, diflucortolone the products include, without limitation, plastics, including, Valerate, fluadrenolone, fluclorolone acetonide, fludrocorti without limitation, natural, synthetic or semi-synthetic Sone, flumethasone pivalate, fluosinolone acetonide, fluoci organic solids that are moldable. In a further embodiment, a 65 nonide, flucortine butylesters, fluocortolone, fluprednidene plastic includes, without limitation, thermoplastics and ther (fluprednylidene) acetate, flurandrenolone, halcinonide, mosetting plastics and include, without limitation, polyeth hydrocortisone acetate, hydrocortisone butyrate, methyl US 9,456,967 B2 27 28 prednisolone, triamcinolone acetonide, cortisone, cortodox In an embodiment, anesthetic actives include, without one, flucetonide, fludrocortisone, difluorosone diacetate, flu limitation, butamben picrate, lidocaine, Xylocalne, benzo radrenolone, fludrocortisone, difluroSone diacetate, caine, bupivacaine, chlorprocaine, dibucaine, etidocaine, fluradrenolone acetonide, medrysone, amcinafel, amcina mepivacaine, tetracaine, dyclonine, hexylcaine, procaine, fide, betamethasone and the balance of its esters, chloro cocaine, ketamine, pramoxine, phenol, and pharmaceuti prednisone, chlorprednisone acetate, clocortelone, clescino cally acceptable salts thereof. lone, dichlorisone, diflurprednate, flucloronide, flunisolide, In an embodiment, analgesic actives include, without fluoromethalone, fluperolone, fluprednisolone, hydrocorti limitation, dyclonine hydrochloride, aloe Vera, fentanyl. Sone Valerate, hydrocortisone cyclopentylpropionate, hydro capsaicin, and the like. In an embodiment, anti-pruritic cortamate, meprednisone, paramethasone, prednisolone, 10 actives include, without limitation, alclometaSone dipropi prednisone, beclomethasone dipropionate, triamcinolone, onate, betamethasone Valerate, and isopropyl myristate and mixtures thereof may be used. In an additional embodi MSD. In an embodiment, anti-microbial actives include, ment, a steroidal anti-inflammatory for use is hydrocorti without limitation, antifungal, antibacterial, and antiseptic SO. compounds. Antifungal compounds include, but are not In an embodiment, nonsteroidal anti-inflammatory agents 15 limited to, compounds such as imidazole antifungals. Spe include, without limitation, oxicams (e.g., piroXicam, isoxi cific antifungals include butocouazole nitrate, miconazole, cam, tenoxicam, Sudoxicam, CP-14.304); Salicylates (e.g., econazole, ketoconazole, oxiconizole, haloprogin, clotrima aspirin, disalcid, benorylate, trilisate, Safapryn, Solprin, Zole, and butenafine HCl, naftifine, terbinafine, ciclopirox, diflunisal, fendosal); acetic acid derivatives (e.g., diclofenac, and tolnaftate. Antibacterial and antiseptic compounds fenclofenac, indomethacin, Sulindac, tolmetin, isoxepac, include phenol-TEA complex, mupirocin, triclosan, chloro furofenac, tiopinac, Zidometacin, acematacin, fentiazac, cresol, chlorbutol, iodine, clindamycin, CAE (Anjinomoto Zomepirac, clindanac, oxepinac, felbinac, ketorolac); fena Co., Inc., containing DL-pyrrolidone Carboxylic acid salt of mates (e.g., mefenamic, meclofenamic, flufenamic, niflu L-Cocoyl Arginine Ethyl Ester), povidone-iodine, poly mic, tolfenamic acids); propionic acid derivatives (e.g., myxin b sulfate-bacitracin, zinc-neomycin Sulfate-hydrocor ibuprofen, naproxen, benoxaprofen, flurbiprofen, ketopro 25 tisone, chloramphenicol, methylbenzethonium chloride, and fen, fenoprofen, fenbufen, indopropfen, pirprofen, carpro erythromycin and antiseptics (e.g., benzalkonium chloride, fen, oxaprozin, pranoprofen, miroprofen, tioxaprofen, benzethonium chloride, chlorhexidine gluconate, mafenide Suprofen, alminoprofen, tiaprofenic), pyrazoles (e.g., phe acetate, nitrofuraZone, nitromersol, antimicrobial deodorant nylbutaZone, oxyphenbutaZone, feprazone, azapropaZone, compounds, antiparasitics, including, without limitation, trimethaZone); and combinations thereof as well as any 30 lindane and the like may be included in compositions of the dermatologically acceptable salts or esters of thereof. invention. COX-2 inhibitors are also suitable for use herein, and In a further embodiment, antimicrobial and antifungal include, but are not limited to, AZD 3582 (AstraZeneca and actives include, without limitation, B-lactam drugs, qui NicOx), Celecoxib (Pharmacia Corp.) (4-5-(4-methylphe nolone drugs, ciprofloxacin, norfloxacin, tetracycline, ami nyl)-3-(trifluoromethyl)-1H-pyrazol-1-ylbenzenesulfona 35 kacin, 2.4,4'-trichloro-2'-hydroxy diphenyl ether, 3.4,4'- mide), Meloxicam (Boehringer Ingelheim Pharmaceuticals) trichlorocarbanilide, phenoxyethanol, phenoxy propanol, (4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1.2GW phenoxyisopropanol, doxycycline, capreomycin, chlorhexi 406381 (GlaxoSmithkline), Etoricoxib (Merck & Co.), Rofe dine, chlortetracycline, oxytetracycline, ethambutol, hex coxib (MERCK & Co.) (4-4-(methylsulfonyl)phenyl-3- amidine isethionate, metronidazole, pentamidine, gentami phenyl-2(5H)-furanone), Lumiracoxib (Novartis Pharma 40 cin, kanamycin, lineomycin, methacycline, methenamine, AG), Valdecoxib (Pharmacia Corp.) (4-(5-methyl-3-phenyl minocycline, neomycin, netilmicin, paromomycin, Strepto 4-isox-azolyl)benzenesulfonamide), and Etodolac (Wyeth mycin, tobramycin, miconazole, tetracycline hydrochloride, Ayerst Laboratories) ((+) 1,8-diethyl-1,3,4,9-tetrahydropy erythromycin, Zinc erythromycin, erythromycin estolate, rano-3,4-blacid). erythromycin Stearate, amikacin Sulfate, doxycycline hydro In a further embodiment, anti-inflammatory or other skin 45 chloride, capreomycin Sulfate, chlorhexidine gluconate, active agents include, without limitation, candelilla wax, chlorhexidine hydrochloride, chlortetracycline hydrochlo bisabolol (e.g., alphabisabolol), aloe Vera, plant sterols (e.g., ride, oxytetracycline hydrochloride, clindamycin hydrochlo phytosterol), Manjistha (extracted from plants in the genus ride, ethambutol hydrochloride, metronidazole hydrochlo Rubia, particularly Rubia Cordifolia), and Guggal (extracted ride, pentamidine hydrochloride, gentamicin Sulfate, from plants in the genus Commiphora, particularly Commi 50 kanamycin Sulfate, lineomycin hydrochloride, methacycline phora Mukul), kola extract, chamomile, red clover extract, hydrochloride, methenamine hippurate, methenamine man sea whip extract, anise oil, garlic oil, ginger extract, Vaso delate, minocycline hydrochloride, neomycin Sulfate, constrictors such as phenylephrine hydrochloride, com netilmicin Sulfate, paromomycin Sulfate, streptomycin Sul pounds of the Licorice (the plant genus/species Glycyrrhiza fate, tobramycin Sulfate, miconazole hydrochloride, aman glabra) family, including glycyrrhetic acid, glycyrrhizic 55 fadine hydrochloride, amanfadine Sulfate, octopirox, acid, and derivatives thereof (e.g., Salts and esters). Suitable parachlorometa Xylenol, nystatin, tolnaftate, Zinc pyrithione salts of the foregoing compounds include metal and ammo and clotrimazole. nium salts. Suitable esters include C-C Saturated or In an embodiment, anti-viral agents include, without unsaturated esters of the acids, preferably Co-C, more limitatin, metal salts (e.g., silver nitrate, copper Sulfate, iron preferably Co-Ca. Specific non-limiting examples of the 60 chloride, etc.) and organic acids (e.g., malic acid, salicylic foregoing include oil soluble licorice extract, the glycyr acid, Succinic acid, benzoic acid, etc.). In particular com rhizic and glycyrrhetic acids themselves, mono ammonium positions which contain additional Suitable anti-viral agents glycyrrhizinate, monopotassium glycyrrhizinate, dipotas include those described in copending U.S. patent application sium glycyrrhizinate, 1-beta-glycyrrhetic acid, Stearyl gly Ser. No. 09/421,084 (Beerse et al.); Ser. No. 09/421,131 cyrrhetinate, and 3-stearyloxy-glycyrrhetinic acid, disodium 65 (Biedermann et al.); Ser. No. 09/420,646 (Morgan et al.); 3-succinyloxy-beta-glycyrrhetinate, and combinations and Ser. No. 09/421,179 (Page et al.), which were each filed thereof. on Oct. 19, 1999. US 9,456,967 B2 29 30 In an embodiment, anti-allergenics include, without limi FGF; transforming growth factor beta; tumor necrosis fac tation, antihistamines. In a further embodiment, antihista tor; non-steroidal anti-inflammatory agents such as benox mines are, without limitation, H or H2 antagonists or other aprofen; retinoids Such as tretinoin; cytokines, such as IL-6, types of histamine release inhibitors. In an additional IL-1 alpha, and IL-1 beta; cell adhesion molecules such as embodiment, H antagonists are sedating or non-sedating, ICAM; glucorcorticoids such as betametaSone; botanical including, without limitation, diphenhydramine (Benadryl), extracts such as aloe, clove, ginseng, rehmannia, Swertia, chlorpheniramine, tripelennamine, promethazine, clemas Sweet orange, Zanthoxylum, Serenoa repens (saw palmetto), tine, doxylamine, benadryl and more. In a further embodi Hypoxis rooperi, Stinging nettle, pumpkin seeds, and rye ment, H-non-sedating antihistamines include, without limi pollen; other botanical extracts including Sandlewood, red tation, astemizole, terfenadine, loratadine etc. Examples of 10 beet root, chrysanthemum, rosemary, burdock root and other H antagonists include cimetadine, famotidine, nizatidine, hair growth promoter activators which are disclosed in DE and ranitidine. In an additional embodiment, histamine 4330597 which is incorporated by reference in its entirety release-inhibitors include, without limitation, cromolyn. herein; homeopathic agents such as Kalium Phosphoricum In a further embodiment, an active is a medicinal for D2, Azadirachta indica D2, and Joborandi DI; genes for treatment of dermatological conditions such as psoriasis, 15 cytokines, growth factors, and male-pattered baldness; anti acne, eczema, and other skin conditions due to disease, fungals such as ketoconazole and elubiol; antibiotics such as pathology, accident, and the like and include, without limi streptomycin; proteins inhibitors such as cycloheximide; tation, burn relief ointments, such as o-amino-p-toluenesul acetazolamide; benoxaprofen; cortisone; diltiazem; fonamide monoacetate; dermatitis relief agents, such as the hexachlorobenzene: hydantoin: nifedipine; penicillamine; active steroid amcinonide, diflorasone diacetate, and hydro phenothaiazines; pinacidil; psoralens, Verapamil: Zidovu cortisone; diaper rash relief agents, such as methylbenze dine; alpha-glucosylated rutin having at least one of the thonium chloride and the like; herpes treatment drugs. Such following rutins: quercetin, isoquercitrin, hespeddin, nar as O-(2-hydroxyethoxy)methylguanine; psoriasis, Sebor ingin, and methylhesperidin, and flavonoids and transgly rhea and Scabicide agents, such as shale oil and derivatives cosidated derivatives thereof which are all disclosed in JP thereof, elubiol, ketoconazole, coal tar and petroleum dis 25 7002677, which is incorporated by reference in its entirety tillates, Salicylic acid, Zinc pyrithione, selenium sulfide, herein; and mixtures thereof. Preferred hair loss treatment hydrocortisone, Sulfur, menthol, psoralen, pramoxine hydro agents include minoxidil, 6-(I-piperdinyl)-2,4-pyrimidinedi chloride anthralin, and methoXSalen; steroids, such as amine-3-oxide, N'-cyano-N-(tert-pentyl)-N'-3-pyridinyl 2-(acetyloxy)-9-fluoro-1'2',3',4'-tetrahydro-11-hydroxy guanidine, finasteride, retinoids and derivatives thereof, pregna-1,4-dieno 16,17-bnaphthalene-3,20-dione and 30 ketoconazole, elubiol or mixtures thereof. 21-chloro-9-fluoro-1,2',3',4'-tetrahydro-11 b-hydroxy In an embodiment, actives Suitable for use in inhibiting pregna-1,4-dieno 167, 17-bnaphthalene-320-dione, and hair growth include, without limitation, serine proteases others including those that are antiinflammatories. In an Such as trypsin; vitamins such as alpha-tocophenol (vitamin additional embodiment, medicinals include, without limita E) and derivatives thereof such as tocophenol acetate and tion, those useful in the treatment of exposure to poison oak, 35 tocophenol palmitate; antineoplastic agents, such as doxo poison ivy, poison Sumac, and the like. These include rubicin, cyclophosphamide, chlormethine, methotrexate, camphor, menthol, benzocaine, butamben picrate, dibu fluorouracil, Vincristine, daunorubicin, bleomycin and caine, dibucaine hydrochloride, dimethisoquin hydrochlo hydroxycarbamide; anticoagulants, such as heparin, hepari ride, dyclonine hydrochloride, lidocaine, metacresol, lido noids, coumaerins, detran and indandiones; antithyroid caine hydrochloride, pramoxine hydrochloride, tetracaine, 40 drugs, such as iodine, thiouracils and carbimazole; lithium tetracaine hydrochloride, benzyl alcohol, camphorated and lithium carbonate; interferons, such as interferon alpha, metacresol, juniper tar, phenol, phenolate Sodium, resorci interferon alpha-2a and interferon alpha-2b; retinoids. Such nol, diphenhydramine hydrochloride, tripelennamine hydro as retinol (vitamin A), isotretinoin: glucocorticoids such as chloride, hydrocortisone, a corticosteroid, and hydrocorti betamethasone, and dexamethoSone; antihyperlipidaemic Sone acetate. In an embodiment, other medication capable of 45 drugs, such as triparanol and clofibrate; thallium; mercury; topical administration can be incorporated in a composition albendazole; allopurinol; amiodarone; amphetamines; of the present invention in an amount Sufficient to perform androgens; bromocriptine; butyrophenones; carbamazepine; its intended function. cholestyramine; cimetidine; clofibrate; danazol; desipra In an embodiment, anticellulite actives include, without mine; diXyrazine; ethambutol; etionamide; fluoxetine; gen limitation, isobutylmethylxanthine, caffeine, theophylline, 50 tamicin, gold salts; hydantoins; ibuprofen; impramine; theobromine, aminophylline, yohimbine, and mixtures immunoglobulins; indandiones; indomethacin; intracon thereof. In an embodiment, examples of actives suitable for azole; levadopa; maprotiline; methysergide; metoprolol; treating hair loss include, without limitation, potassium metyrapone; nadolol; nicotinic acid; potassium thiocyanate; channel openers or peripheral vasodilators such as minoxi propranolol, pyridostimine; salicylates; SulfaSalazine; ter dil, diazoxide, and compounds such as N*-cyano-N-(tert 55 fenadine; thiamphenicol; thiouracils; trimethadione; pentyl)-N'-3-pyridinyl-guanidine (“P-1075”) as disclosed in troparanol; valproic acid; and mixtures thereof. Preferred U.S. Pat. No. 5.244.664, which is incorporated herein by hair growth inhibitory agents include serine proteases, reti reference; vitamins, such as vitamin E and vitamin C, and nol, isotretinoin, betamethoisone, alpha-tocophenol and derivatives thereof such as vitamin E acetate and vitamin C derivatives thereof, or mixtures thereof. palmitate; hormones, such as erythropoietin, prostaglandins, 60 In an embodiment, hair bleaching agents include, without Such as prostaglandin El and prostaglandin F2-alpha; fatty limitation, perborate or persulfate salts. acids, Such as oleic acid; diuretics such as spironolactone; In an embodiment, a Sunscreen composition protects heat shock proteins (“HSP”), such as HSP 27 and HSP 72: against UV radiation given off by man made devices. In a calcium channel blockers, such as Verapamil HCL, nife further embodiment, a Sunscreen composition protects dipine, and diltiazemamiloride; immunosuppressant drugs, 65 against UV radiation given off by fluorescent light bulbs, such as cyclosporin and Fk-506; 5alpha-reductase inhibitors wherein the protective coating applied to a fluorescent light such as finasteride; growth factors such as, EGF, IGF and bulb has gaps through which UV radiation is emitted. US 9,456,967 B2 31 32 In an embodiment, deodorant compounds include, with and its salts, ascorbyl esters of fatty acids, ascorbic acid out limitation, astringent salts and bioactive compounds. In derivatives (e.g., magnesium ascorbyl phosphate, Sodium an additional embodiment, astringent salts include, without ascorbyl phosphate, ascorbyl Sorbate), tocopherol, tocoph limitation, organic and inorganic salts of aluminum, Zirco erol acetate, other esters oftocopherol, tocotrienols and their nium, zinc, and mixtures thereof. In an additional embodi esters, and 6-hydroxy-2,5,7,8-tetramethylchroman-2-car ment, anions of the astringent salt include, without limita boxylic acid (commercially available under the tradename tion, Sulfate, chloride, chlorohydroxide, alum, formate, TROLOX). Other suitable antioxidants include uric acid and lactate, benzyl Sulfonate or phenyl Sulfonate. In an embodi its salts and alkyl esters, Sorbic acid and its salts, lipoic acid, ment, antiperspirant astringent salts include, without limi amines (e.g., N,N-diethylhydroxylamine, amino-guanidine), tation, aluminum halides, aluminum hydroxyhalides, Zirco 10 Sulfhydryl compounds (e.g., glutathione, N-acetyl cysteine), nyl oxyhalides, Zirconyl hydroxyhalides, and mixtures dihydroxy fumaric acid and its salts, lycine pidolate, argi thereof. In a further embodiment, aluminum salts include, nine pilolate, nordihydroguaiaretic acid, bioflavonoids, cur without limitation, aluminum chloride and the aluminum cumin, lysine, methionine, proline, Superoxide dismutase, hydroxyhalides having the general formula silymarin, tea extracts, grape skin/seed extracts, melanin, Al(OH),QXH2O, wherein Q is chlorine, bromine or 15 and rosemary extracts may be used. iodine; x is about 2 to about 5: x+y is about 6, wherein X and In a further embodiment, antioxidants include, without y are not necessarily integers; and X is about 1 to about 6. limitation, photostable antioxidants, including, without limi In a further embodiment, Zirconium compounds include, tation, a photostable antioxidant marketed under the trade without limitation, Zirconium oxy salts and Zirconium name EMBLICA by EMD Chemicals. In an embodiment, hydroxy salts, also referred to as Zirconyl salts and Zirconyl antioxidants, including, without limitation, photostable anti hydroxy salts, and represented by the general empirical oxidants (e.g., EMBLICA), are included in a Sunscreen formula ZrO(OH)2-nz L, wherein Z varies from about 0.9 composition at about 0.05 to about 5% (w/v), or about 0.05 to about 2 and is not necessarily an integer; n is the Valence to about 2% (w/v), or about 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, of L: 2-nz is greater than or equal to 0; and L is selected, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, without limitation, from the group consisting of halides, 25 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.25%, 2.5%, 2.75%, nitrate, Sulfamate, Sulfate, and mixtures thereof. 3%, 3.25%, 3.5%, 3.75%, 4%, 4.25%, 4.5%, 4.75%, or 5% In an embodiment, deodorant compounds include, with (w/v), or in a bodywash, shampoo, conditioner, gel, Soap, out limitation, aluminum bromohydrate, potassium alum, hand sanitizer, cream, lotion, spray or mousse with or Sodium aluminum chlorohydroxy lactate, aluminum sulfate, without a sunscreen active agent at about 0.02 to about 2% aluminum chlorohydrate, aluminum-zirconium tetrachloro 30 (w/v), or about 0.02 to about 1% (w/v), or about 0.01%, hydrate, an aluminum-zirconium polychlorohydrate com 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, plexed with glycine, aluminum-zirconium trichlorohydrate, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, aluminum-zirconium octachlorohydrate, aluminum sesqui 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, chlorohydrate, aluminum sesquichlorohydrex PG, alumi 1.8%, 1.9%, 2% or more. num chlorohydrex PEG, aluminum zirconium octachloro 35 In an embodiment, insect repellents include, without hydrex glycine complex, aluminum zirconium limitation, N,N-Diethyl-m-toluamide, frequently called pentachlorohydrex glycine complex, aluminum zirconium “DEET and available in the form of a concentrate contain tetrachlorohydrex glycine complex, aluminum zirconium ing at least about 95 percent DEET, dimethyl phthalate, ethyl trichlorohydrex glycine complex, aluminum chlorohydrex hexanediol, indalone, di-n-propylisocinchoronate, bicyclo PG, zirconium chlorohydrate, aluminum dichlorohydrate, 40 heptene, dicarboximide and tetrahydrofuraldehyde. In a fur aluminum dichlorohydrex PEG, aluminum dichlorohydrex ther embodiment, plant-derived materials with insect repel PG, aluminum sesquichlorohydrex PG, aluminum chloride, lent activity include, without limitation, citronella oil and aluminum zirconium pentachlorohydrate, numerous other other sources of citronella (including lemon grass oil), useful antiperspirant compounds listed in the CTFA Hand limonene, rosemary oil and eucalyptus oil. Choice of an book at p. 56, incorporated herein by reference, and mixtures 45 insect repellent will frequently be influenced by the odor of thereof. the repellent. In a further embodiment, DEET is used at high In an embodiment, the deodorant compound includes, concentrations, including, without limitation, up to about without limitation, a bacteriostatic quaternary ammonium 15% or more, while plant-derived substances are typically compound, Such as, for example, without limitation, cetyl used in much lower amounts, such as 0.1% or less. trimethyl ammonium bromide, cetyl pyridinium chloride, 50 In an embodiment, skin care agents include, without benzethonium chloride, diisobutylbenzoxyethoxyethyldim limitation, those found in the CTFA Cosmetic Ingredient ethylbenzyl ammonium chloride, sodium N-lauryl sar Handbook, Seventh Edition, 1997 and the Eighth Edition, cosine, Sodium N-polymethyl sarcosine, lauroyl sarcosine, 2000 and Remington’s Pharmaceutical Sciences, 20th Ed., N-myristolyl glycine, potassium N-lauroyl sarcosine, and Lippincott Williams & Witkins, Baltimore, Md. (2000) Stearyl trimethyl ammonium chloride; or a bioactive com 55 (hereinafter Remington's), U.S. Pharmacopeia and National pound; or a carbonate or bicarbonate salt, such as, for Formulary. The United States Pharmacopeial Convention, example, the alkali metal carbonates and bicarbonates, and Inc., Rockville, Md. and Physician’s Desk Reference, Medi the ammonium and tetralkylammonium carbonates and cal Economics Co., Inc., Oradell, N.J. all of which are bicarbonates. In a further embodiment, deodorant com incorporated herein by reference. pounds include, without limitation, chlorophyllin copper 60 In an embodiment, the invention provides cellulose complex, aluminum chloride, aluminum chloride hexahy derived capsules, including, without limitation, microcap drate, and methylbenzethonium chloride. Sules, that act as a protective barrier on the skin when used In an embodiment, antioxidants include, without limita either alone, or as an additive in a bodywash, shampoo, tion, propyl, octyl and dodecyl esters of gallic acid, buty conditioner, gel, Soap, hand sanitizer, cream, lotion, spray lated hydroxyanisole (BHA, usually purchased as a mixture 65 and mousse. In these embodiments, the cellulose derived of ortho and meta isomers), butylated hydroxytoluene capsules, including, without limitation, microcapsules, may (BHT), nordihydroguaiaretic acid, Vitamin A, ascorbic acid be used without any additional active ingredients (i.e., US 9,456,967 B2 33 34 empty), providing a physical barrier, or they may be used 4,080,310; 4,048,301; 4,009.256; and 3,186,911, those with additional encapsulated Sunscreen active agents and available commercially including, without limitation, from additional agents that enhance their barrier function. In an Union Carbide Corp. under the trademark POLYMER JR., embodiment, the cellulose derived capsules, including, with from Celanese-Stein Hall under the trademark JAGUAR, out limitation, microcapsules, contain one or more agents 5 from GAF Corporation under the tradename Gafquatm and that absorb radiation, such as graphite, lead, tungsten, and from Merck & Co., Inc under the trademark MEROUAT by. others known in the art, or agents that reflect radiation Such In a further embodiment, a cationic component includes, as ceramic beads. In an embodiment, because the cellulose without limitation, Merquat 100, a highly charged cationic derived capsules, including, without limitation, microcap dimethyldiallylammonium chloride homopolymer, and Sules, are designed so as to experience minimal or no 10 MERQUATTM 550, a highly charged cationic copolymer breakage when applied to the skin, as well as to experience prepared with dimethyldiallylammonium chloride and acry minimal penetration of the skin, it is possible to use even lamide. These materials are designated in the CTFA diction toxic Substances (e.g., lead) that provide a screening effect. ary as Quaternium.40 and Quaternium-41, respectively. The cellulose derived capsules, including, without limita In an embodiment, the Sunscreen composition includes, tion, microcapsules, are eventually removed from the skin 15 without limitation, polyguarterniums. In a further embodi through repeated washing and/or normal sloughing of the ment, the Sunscreen composition includes, without limita external skin cell layers. Especially for agents used for tion, quaternized material in powder form, including, but not one-time or very few exposures. Such as can occur for limited to, the polyguarterniums. In an additional embodi personnel engaged in combating or containing terrorist ment, polyguarterniums include, but are not limited to, attacks or in warfare, the invention provides a means to polyguarternium-4, -7, -11, -22, -37 -44, -5, and -64 and deliver a last line of defense on the skin of personnel where CELQUAT L-200 for polyguarternium-4. Useful in some the active used in the microcapsules may be one that is not embodiments of the invention is a dry cationic component, appropriate for long-term use, but that is appropriate for a Such as sold under the tradename CAE (Anjinomoto Co., limited number of applications in order to protect the wearer Inc.), containing DL-pyrrolidone Carboxylic acid salt of from a greater risk (e.g., cellulose derived capsules, includ 25 L-Cocoyl Arginine Ethyl Ester, which is a cationic agent ing, without limitation, microcapsules, encapsulating lead to useful for binding to proteins and providing an antimicrobial protect against a radiation attack). effect. In an embodiment, a Sunscreen composition includes, In an embodiment, the cellulose derived capsules, includ without limitation, a cationic component, including, without ing, without limitation, microcapsules, is prepared so to limitation, a cationic polymer that comprises about 0.1 to experience no or minimal breakage when applied to the skin, 30 about 20%, or about 0.1 to about 10%, or about 0.5 to about either as is or in the form of a bodywash, shampoo, condi 10%, or about 1 to about 10%, or about 0.5 to about 5%, or tioner, gel, Soap, hand sanitizer, cream, lotion, spray or about 0.5 to about 3% or about 1 to about 5%, or about 1 to mousse. In a further embodiment, the cellulose derived about 3%, or about 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, capsules, including, without limitation, microcapsules, is 0.7%, 0.8%, 0.9%, 1% or 1%, 2%, 3%, 4%, 5%, 6%, 7%, prepared so to experience various degrees of breakage, on 35 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, average, when applied as is or in a bodywash, shampoo, 19%. 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, conditioner, gel, Soap, hand sanitizer, cream, spray or 29%, 30%, 35%, 40%, 45%, 50%, 55%, 60%. 65% or more mousse. In an embodiment, the cellulose derived capsules, of the total Sunscreen composition. In an additional embodi including, without limitation, microcapsules, is prepared so ment, the cationic component is polyguarternium-4. In as to experience about 0% breakage, or breakage in a range 40 another embodiment, the polyguarternium-4 is present at from about 0.1, 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, about 1% (w/v) of the sunscreen composition. 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, In an embodiment, a bodywash, shampoo, conditioner, 30, 31, 32, 33, 34, 35, 36, 37,38, 39, 40, 41, 42, 43, 44, 45, gel, Soap, hand sanitizer, cream, lotion, spray or mousse 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, combined with a Sunscreen composition includes, without 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72,73, 74, 75, 76, 77, 45 limitation, a cationic component, including, without limita 78, 79, 80, 81, 82, 83, 84,85, 86, 87, 88, 89,90, 91, 92,93, tion, a cationic polymer that comprises about 0.1 to about 94, 95, 96, 97, 98 or 99% after application (or application 20%, or about 0.1 to about 10%, or about 0.5 to about 10%, and rinsing in the case of a bodywash, shampoo, conditioner, or about 1 to about 10%, or about 0.5 to about 5%, or about gel, Soap, hand sanitizer, cream, and possibly with a lotion, 0.5 to about 3% or about 1 to about 5%, or about 1 to about spray or mousse containing the cellulose derived capsules, 50 3%, or about 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, including, without limitation, microcapsules.). In a further 0.8%, 0.9%, 1% or 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, embodiment, the cellulose derived capsules, including, with 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, out limitation, microcapsules, are formulated so as to break 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, open in response to conditions that occur on the skin, so that 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65% or more of the after application the cellulose derived capsules, including, 55 total Sunscreen composition. In an additional embodiment, without limitation, microcapsules, act to release their con the cationic component is polyguarternium-4. In another tents in a time-release or controlled manner. In an embodi embodiment, the polyguarternium-4 is present at about 1% ment, skin or hair conditions can vary with the user's (w/v) of the Sunscreen composition. In an embodiment, a environment, the variation of which can trigger breakage of bodywash, shampoo, conditioner, gel, Soap, hand sanitizer, microcapsules, include pH, temperature, friction, exposure 60 cream, lotion, spray or mousse combined with a Sunscreen to light or air, pressure, and the like. composition includes, without limitation, a cationic compo In an embodiment the Sunscreen composition, includes, nent, including, without limitation, a cationic polymer that without limitation, a cationic component, including, without comprises about 0.03 to about 7%, or about 0.03 to about limitation, cationic polymers. In an embodiment, cationic 4%, or about 0.2 to about 4%, or about 0.3 to about 4%, or components, including, without limitation, cationic poly 65 about 0.2 to about 2%, or about 0.3 to about 4%, or about 0.3 mers, include, without limitation, those described in U.S. to about 1%, or about 0.3 or 0.4% of the total composition. Pat. Nos. 6,224,852; 3,816,616; 4,272,515; 4,298,494; In some embodiments, the cationic component is polyguar US 9,456,967 B2 35 36 ternium-4, in Some embodiments the polyguarternium-4 is limitation, polythylenes, including, without limitation, those present at about 0.33% (w/v) of the total combined compo available from New Phase Technologies as PERFOR sition. MALENE 400, a polyethylene having a molecular weight of In an embodiment, a Sunscreen composition includes, 400 or polyethylene 2000 (molecular weight of 2000), without limitation, a film barrier system, typically a hydro which is available from New Phase Technologies as PER phobic layer that serves to maintain the residual Sunscreen FORMALENE 2000. In an additional embodiment, a suit after rinse. In an embodiment, a film barrier system includes, able film former/waterproofing agent includes, without limi without limitation, petrolatum, silicon derivatives, poly tation, synthetic wax, also available from New Phase mers, including, without limitation, those with carboxylic Technologies as PERFORMAV-825 octadecene/MA copo ends. In a further embodiment, a film former includes, 10 lymer or any film former chemistry known in the art. In an without limitation, emollient esters, lanolin derivatives (e.g., embodiment, film formers include, without limitation, aca acetylated lanolins), and Superfatted oils. In an additional cia gum, cellulose derivatives, guar derivatives and all those embodiment, a film former includes, without limitation, set forth on pages 6869 of the C.T.F. A. Cosmetic Ingredient MOISTUREGUARDTM, which contains petrolatum, dime Handbook, First Edition, 1988, which is hereby incorporated thicone, Stearamidopropyl dimethylamine Stearate, and 15 by reference. Such film formers include acrylamides copo tocopheryl acetate, available from Engelhard. lymer, acrylamide/sodium acrylate copolymer, acrylate/ In an embodiment, a Sunscreen composition includes, acrylamide copolymer, acrylate? ammonium methacrylate without limitation, an acrylic co-polymer as a film former. copolymer, acrylates copolymer, acrylates/diacetoneacryl An additional embodiment, a Sunscreen composition amide copolymer, acrylic/acrylate copolymer, adipic acid/ includes, without limitation, a liquid acrylic copolymer dimethylaminohydroxypropyl diethlenetriamine copolymer, formulation, including, without limitation, DERMACRYL, adipic acid/epoxypropyl/diethlenetriamine copolymer, albu marketed by National Starch and Chemical. Acrylic co men, allyl Stearate/VA copolymer, aminoethylacrylate phos polymers may be included in Sunscreen additives at about phate/acrylate copolymer, ammonium acrylates copolymer, 0.1 to about 5%, or about 0.2 to about 3%, or about 0.2%, ammonium alginate, ammonium vinyl acetate/acrylates 0.3%, 0.4%, or 0.5%, or in sunscreen/bodywashes at about 25 copolymer, AMP acrylates/diacetoneacrylamide copolymer, 0.05 to about 2%, or about 0.1 to about 1%, or about 0.05%, balsam canada, balsam oregon, balsam peru, balsam tolu, 0.1%, 0.2%, 0.3%, 0.4%, or 0.5% or about 0.1%, 0.2%, benzol acid/phthalic anhydride?pentaerythritol/neopentyl 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1% or 1%, 2%, glycol/palmitic acid copolymer, benzoin extract, butadiene/ 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10% or more. acrylonitrile copolymer, butylated urea-formaldehyde resin, In an embodiment, a secondary film former can be 30 butyl benzoic acid/phthalic anhydride trimethylolethane included in a Sunscreen composition and include, without copolymer, butyl ester of ethylene maleic anhydride copo limitation, keratin or other protein derivative in an amino lymer, butyl ester of PVM/MA copolymer, calcium carra acid complex Such as cysteine. In an embodiment, a film geenan, calcium/sodium PVM/MA copolymer, carboxym former is present in a Sunscreen composition in the range of ethyl hydroxyethyl cellulose, cellulose gum, collodion, about 0.1 to about 25%, or about 1 to about 10%; or about 35 copal, corn starch/acrylamide/sodium acrylate copolymer, 2 to about 6%; or about 3, 4, or 5% or about 0.1%, 0.2%, damar, diethylene glycolamine/epichlorohydrin/piperazine 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1% or 1%, 2%, copolymer, DMJ-IF, dodecanedoic acid/cetearyl alcoholgly 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, col copolymer, ethylcellulose, ethylene? acrylate copolymer, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, ethylene/maleic anhydride copolymer, ethylene/vinyl 25%, 26%, 27%, 28%, 29%, 30%, 35%, 40%, 45%, 50%, 40 acetate copolymer, ethyl ester of PVM/fvlA copolymer, 55%, 60%, 65% or more. In an additional embodiment, a flexible collodian, gum benzoin, gutta percha, hydroxybutyl film former, including, without limitation, MoistureGuard is methylcellulose, hydroxyethylcellulose, hydroxyethyl ethyl used at a concentration of about 4.2%. In a further embodi cellulose, hydroxypropylcellulose, hydroxypropyl guar, ment, a film former is used at a 4.2% concentration. hydroxypropyl methylcellulose, isopropyl ester of PVM/ In an embodiment, an agent can have more than one 45 MA copolymer, maltodextrin, melamine/formaldehyde function. For example, without limitation, inorganic block resin, methacryloyl ethyl betainelmethacrylates copolymer, ers such as Tioveil and Spectraveil (both of the Tioxide nitrocellulose, octylacrylamide/acrylates/butylaminoethyl Group), can act as film-formers and other advantageous uses methacrylate copolymer, octylacrylamide/acrylates copoly here. In addition, many emollients may also perform a film mer, phthalic anhydride/glycerin/glycidyl decanoate copo former function in that they provide a barrier on the skin. 50 lymer, phthalic/trimellitic/glycols copolymer, Thus, in a further embodiment, a Sunscreen composition polyacrylamide, polyacrylamidomethylpropane Sulfone includes, without limitation, water-insoluble emollients that acid, polyacrylic acid, polybutylene terephthalate, polychlo include, without limitation, fatty acids such as oleic and rotrifluoroethylene, polyethylacrylate, polyethylene, poly stearic: fatty alcohols such as cetyl, and hexadecyl (EN ethylene terephthalate, polyisobutene, Polyguarternium-1, JAY); esters such as diisopropyl adipate, benzoic acid esters 55 Polyguarternium-2, Polyguarternium-4, Polyguarternium-5. of Co-Cs alcohols, and isononyl iso-nonanoate: alkanes Polyguarternium-6, Polycuarternium-7. Polyguarternium-8, Such as mineral oil; silicones; Such as dimethyl polysiloxane Polyguarternium-9, Polyguarternium-10, Polyguarternium and ethers such as polyoxypropylene butyl ethers and poly 11, Polyguarternium-12, Polyguarternium-13, Polyguarter oxypropylene cetyl ethers. In an embodiment, a water nium-14, Polyguarternium-15, polystyrene, polyvinyl insoluble emollient is used at a concentration from about 2% 60 acetate, polyvinyl alcohol, polyvinylbutyral, polyvinyl imi to about 15% by weight, 4% to about 10% or about 0.1%, dazolinium acetate, polyvinyl laurate, polyvinyl methyl 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1% or ether, potassium carrageenan, PVM/MA copolymer, PVP. 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, PVP/dimethylaminoethymethacrylate copolymer, PVP/ei 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, cosene copolymer, PVP/ethyl methacrylate/methacrylic acid 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 35%, 40%, 65 copolyerm, PVP/hexadecene copolymer, PVPNA copoly 45%, 50%, 55%, 60%. 65% or more (w/v) of the composi mer, PVP/vinyl acetate/itaconic acid copolymer, rosin, tion. In a further embodiment film formers include, without serum albumin, shellac, Sodium acrylate/vinyl alcohol, US 9,456,967 B2 37 38 copolymer, Sodium carrageen, Sodium polymethacrylate, In an embodiment, a Sunscreen composition includes, Sodium polystyrene Sulfonate, starch/acrylates/acrylamide without limitation, a chelating agent. In a further embodi copolymer, starch diethylaminoethyl ether, steaxyvinyl ment, chelating agents include, without limitation, Sub ether/maleic anhydride copolymer, styrenefacrylate/acrylo stances used to chelate or bind metallic ions, such as with a nitrile copolymer, styrenefacrylate/ammonium methacrylate heterocyclic ring structure so that the ion is held by chemical copolymer, styrene/maleic anhydride copolymer, styrene? bonds from each of the participating rings. In a further PVP copolymer, sucrose benzoate/Sucrose acetate isobu embodiment, chelating agents include, without limitation, tyrate/butylbenzyl phthalate copolymer, sucrose benzoate/ ethylene diaminetetraacetic acid (EDTA), EDTA disodium, sucrose acetate isobutyrate/butyl benzyl phthalate/methyl calcium disodium edetate, EDTA trisodium, EDTA tetraso methacrylate copolymer, Sucrose benzoate/Sucrose acetate 10 dium and EDTA dipotassium. In an embodiment, one or isobutyrate copolymer, toluenesulfonamide/formaldehyde more chelating agents is included in a Sunscreen composi tion in amounts ranging from about 0.001 to about 0.2 resin, tragacath gum, vinyl acetate/crotonates copolymer, weight percent, or about 0.01% w/v or about 0.1%, 0.2%, vinyl acetate/crotonic acid copolymer, vinyl acetate/crotonic 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1% or 1%, 2%, acid/methacryloxybenzophenon-1 copolymer, vinyl acetate/ 15 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, crotonic aid/vinyl neodecanoate copolymer, Zein and those 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, set forth in U.S. Pat. Nos. 6,838,419; 6,838,088: 6,780,422: 25%, 26%, 27%, 28%, 29%, 30%, 35%, 40%, 45%, 50%, 6,531,118; and 5,916,541, all of which are incorporated 55%, 60%. 65% or more (w/v). herein by reference. In an embodiment, a Sunscreen composition includes, In an embodiment, a Sunscreen composition includes, without limitation, thickening agents or gellants to adjust the without limitation, a wide variety of additional components texture and Viscosity of the composition. In an embodiment, selected so as to avoid any undesirable reaction with the thickening agents or gellants include, without limitation, primary components (e.g., one or more of the Sunscreen CARBOPOLTM resins (e.g., 934, 971, 974, 980, 981 and active agents) of the composition. The CTFA Cosmetic PEMULENTM ITR-1 and TR-2) both CARBOPOLTM and Ingredient Handbook, Seventh Edition, 1997 and the Eighth 25 PEMULENTM are registered trademarks of BF Goodrich), Edition, 2000 (incorporated by reference herein), provide a Noveon AA-1, ETD resins, and ULTREZTM resins regis broad source of possible cosmetic and pharmaceutical ingre tered trademark, BF Goodrich or carbomers. dients typically used in skin care compositions. In an In an embodiment, a Sunscreen composition includes, embodiment, additional components include, without limi without limitation a non-polar wax, including, without limi tation, one or more of the following: Absorbents, abrasives, 30 tation, ester waxes, diester waxes, hydrocarbon waxes, sili anticaking agents, antifoaming agents, binders, biological cone waxes and triglyceride waxes and mixtures thereof. In additives, buffering agents, bulking agents, chelating agents/ another embodiment, a sunscreen composition includes, sequestrants (e.g., disodium EDTA), chemical additives, without limitation, a liquid hydrocarbon (similar to pentane), colorants, cosmetic astringents, cosmetic biocides, denatur and/or a cationic foaming agent derived from arginine and or ants, drug astringents, emollients (including glycerin alo 35 cysteine. Vera, and Vitamins A, C, and D hydrating agents and skin In an embodiment, additional ingredients which can be protectants), foam boosters, fragrance components, gums, present in a Sunscreen composition include, without limita humectants/moisturizers (including urea, guanidine, gly tion, fragrance, dyes, antimicrobial materials such as triclo colic acid, polyhydroxy alcohols such as Sorbitol, glycerin, carban, triclosan, iodophors, iodine formulations, phenolic hexanetriol, propylene glycol, hexylene glycol and the like, 40 compounds, e.g. hexachlorophene, and bisbiguanides, e.g. polyethylene glycol, Sugars and starches, Sugar and starch chlorhexidene gluconate, and the like. See, e.g. U.S. Pat. derivatives, D-panthenol, hyaluronic acid, lactamide Nos. 6,827,795; 6,517,854; 6,010,817; 5,173,216; 5,719, monoethanolamine, acetamide monoethanolamine, and 113: 5,259,984: 5,562,912; 5,629,006; 5,728,662; 5,767, mixtures thereof), hydrotropes, neutralizing agents, opaci 163; 5,750,579; 5,591.442; 5,650,143; 5,772,640; and fying agents and pigments, pH adjusters, plasticizers, pre 45 4,478,821. servatives, propellants, reducing agents, skin bleaching In an embodiment, the components comprising a Sun agents, skin protectants, solubilizing agents, and Suspending screen composition are mixed in, without limitation, water agents (e.g., Carbomer 1382). or oil. In an embodiment, a Sunscreen composition or In an embodiment, the Sunscreen composition includes, Sunscreen composition combined with a bodywash, sham without limitation, a preservative, including, without limi 50 poo, conditioner, gel, Soap, hand sanitizer, cream, lotion, tation, citric acid, tartaric acid, phosphoric acid, iminodi spray or mousse includes, without limitation, one or more acetic acid, nitrilotriacetic acid, hydroxyethyleneaminodi surfactants. The use of surfactants in bodywashes is well acetic acid and ethylenediaminetetraacetic acid and salts known in the art. Any surfactant known in the art and thereof, para-hydroxybenzoates Such as butyl paraben, appropriate for a bodywash, shampoo, conditioner, gel. methyl paraben and propyl paraben; imidazolines (e.g., 55 Soap, hand sanitizer, cream, lotion, spray or mousse may be imidiazolinylurea), triclosan, hydantoins (e.g., dimethyl used. See, McCutcheon's Detergents & Emulsifiers, M.C. oldimethylhydantoin), isothiazolidinone compounds and Publishing Co. (North American edition 1989); Schwartz, et mixtures thereof, KATHON CG and KATHON CGII, which al., Surface Active Agents, Their Chemistry and Technology, contain methylchloroisothiazolinone and methylisothiazoli New York, Interscience Publishers, 1949, and U.S. Pat. Nos. none (Rohm and Haas). In an embodiment, the quantity of 60 6,096,697; 4,741,855; 4,788,066; 5,104,646; 5,106,609: preservative is in the range from 0.001 to 2%, preferably 2,658,072; 2,438,091; 2,528,378; 2,486,921; 2,486,922: from 0.01 to 0.2% or about 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 2,396,278; 2,979,465; 3,179,599; 5,322,643; 5,084.212: 0.6%, 0.7%, 0.8%, 0.9%, 1% or 1%, 2%, 3%, 4%, 5%, 6%, 3,332,880; 4,122,029; 4,265,878; 4,421,769; 3,929,678: 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 3,959,461; 4,387,090; 4,303,543; and 6,224,852; and in 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 65 British Patent Nos. 848,224 and 791,415. Also see CTFA 28%, 29%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65% or Cosmetic Ingredient Dictionary, 4th Edition 1991, pages 509 O. 514 for various long chain alkyl cationic Surfactants; and US 9,456,967 B2 39 40 Richmond, James M., Cationic Surfactants, Marcel Dekker, tation, Sodium laureth Sulfate and ammonium laureth Sulfate. Inc., New York and Basel, 1990. Sodium laureth sulfate is an article of commerce available In an embodiment, Surfactant(s) includes, without limita from a number of Sources, including under the tradename tion, cationic, anionic, nonionic, Zwitterionic, amphoteric, or Steal CS-370 from Stepan. It has a molecular formula any combination of surfactants thereof. In a further embodi 5 CH(CH2)CH(OCHCH)OSONa and conforms to the ment, Surfactants include, without limitation, alkyl and alkyl following structure: ether Sulfates, Sulfated monoglycerides, Sulfonated olefins, alkyl aryl Sulfonates, primary or secondary alkane Sul fonates, alkyl Sulfo Succinates, acyl taurates, acyl isethion O 10 | ates, alkyl glycerylether Sulfonate, Sulfonated methyl esters, O-S-O O Sulfonated fatty acids, alkyl phosphates, ethoxylated alkyl | pi phosphates, acyl glutamates, acyl sarcosinates, alkyl Sul Na"a O foacetates, acylated peptides, alkyl ether carboxylates, acyl lactylates, anionic fluoroSurfactants, and combinations In an embodiment, a Sunscreen composition or a body thereof. Combinations of anionic Surfactants can be used 15 effectively in the present invention. In a further embodiment, wash, shampoo, conditioner, gel, Soap, hand sanitizer, alkyl Sulfates include, without limitation, Sodium, ammo cream, lotion, spray or mousse combined with a Sunscreen nium, potassium, magnesium, or TEA salts of lauryl or composition, includes, without limitation, Sodium laureth myristyl sulfate or ammonium, Sodium, magnesium, or TEA sulfate at a concentration of from about 10% to about 15% laureth-3 sulfate. or from about 7.5% to about 8.5%. In a further embodiment, In an embodiment, a Sunscreen composition has a surfac ammonium laureth Sulfate is used in combination with an tant concentration of about 0.01% to about 10% (w/v). In a alkyl glucoside, wherein the alkyl glucoside includes, with further embodiment, a Sunscreen composition has a surfac out limitation, decyl glucoside. The combination of ammo tant concentration of about 3% to about 5%. In a further nium laureth Sulfate and decyl glucoside is sold under the embodiment, a Sunscreen composition has a surfactant con 25 tradename Plantaren PS-100 by Cognis. In an embodiment, centration of at least 0.01%, at least 0.02%, at least 0.03%, ammonium laureth Sulfate in combination with decyl glu at least 0.04%, at least 0.05%, at least 0.06%, at least 0.07%, coside is present in a Sunscreen composition or a bodywash, at least 0.08%, at least 0.09%, at least 0.1%, at least 0.25%, shampoo, conditioner, gel, Soap, hand sanitizer, cream, at least 0.5%, at least 0.75%, at least 1%, at least 1.25%, at lotion, spray or mousse combined with a Sunscreen compo least 1.5%, at least 1.75%, at least 2%, at least 2.25%, at 30 sition at a concentration of from about 5% to about 10%, or least 2.5%, at least 2.75%, at least 3%, at least 3.25%, at from about 7.5% to about 8.5%. least 3.5%, at least 3.75%, at least 4%, at least 4.25%, at In a further embodiment, a lathering surfactant includes least 4.5%, at least 4.75%, at least 5%, at least 5.25%, at one, two, three or more anionic lathering Surfactants, includ least 5.5%, at least 5.75%, at least 6%, at least 6.25%, at ing, without limitation, Sulfates, including, without limita least 6.5%, at least 6.75%, at least 7%, at least 7.25%, at 35 tion, Sodium laureth Sulfate and ammonium laureth Sulfate. least 7.5%, at least 7.75%, at least 8%, at least 8.25%, at In an embodiment, sodium laureth Sulfate and ammonium least 8.5%, at least 8.75%, at least 9%, at least 9.25%, at laureth sulfate are combined with decyl glucoside. In an least 9.5%, at least 9.75%, at least 10%, at least 11%, at least additional embodiment, the two Sulfates are present at a 12%, at least 13%, at least 14%, at least 15%, at least 16%, combined concentration of from about 15% to about 25%. at least 17%, at least 18%, at least 19%, at least 20%, at least 40 In a further embodiment, anionic Surfactants, include, 21%, at least 22%, at least 23%, at least 24%, at least 25% without limitation, sulfated monoglycerides of the form (w/v). R1CO-O CH-C(OH)H-CH-O SOM, wherein In an embodiment, a Sunscreen composition with a Sur R1 is a saturated or unsaturated, branched or unbranched factant concentration of about 0.01% to about 5% or about alkyl group from about 8 to about 24 carbon atoms, and M 3% to about 5% and wherein the sunscreen active agent or 45 is a water-soluble cation Such as ammonium, Sodium, potas agents are encapsulated within a cellulose derived capsule sium, magnesium, triethanolamine, diethanolamine, when applied to the wet skin of an individual spreads across monoethanolamine and sodium cocomonoglyceride Sulfate. the Surface to which the Sunscreen composition is applied In a further embodiment, anionic Surfactants include, with with the same degree of evenness and ease as a Sunscreen out limitation, olefin sulfonates of the form R1SOM, composition with a higher concentration of Surfactant. In a 50 wherein R1 is a mono-olefin having from about 12 to about further embodiment, a Sunscreen composition with a Sur 24 carbon atoms, and M is a water-soluble cation Such as factant concentration of about 0.01% to about 5% or about ammonium, Sodium, potassium, magnesium, trietha 3% to about 5% lathers less than a sunscreen composition nolamine, diethanolamine and monoethanolamine. In an with a higher Surfactant concentration. In an embodiment, a embodiment, a sulfonated olefin is sodium C14/C16 alpha Sunscreen composition with a Surfactant concentration of 55 olefin Sulfonate. In a further embodiment, anionic Surfac about 0.01% to about 5% or about 3% to about 5% also tants, include, without limitation, linear alkylbenzene Sul includes film formers, secondary polymers and emulsifiers. fonates of the form R—CH, SOM, wherein R1 is a In an embodiment, a surfactant is an environmentally saturated or unsaturated, branched or unbranched alkyl favourable Surfactant including, without limitation, dodecyl group from about 8 to about 24 carbon atoms, and M is a glucosides. 60 water-soluble cation such as ammonium, Sodium, potas In an embodiment, a Surfactant is a lathering Surfactant. In sium, magnesium, triethanolamine, diethanolamine a further embodiment, a lathering Surfactant has a log P of monoethanolamine and Sodium dodecylbenzene Sulfonate. less than about 2.5 that produces foam when mixed with and In an additional embodiment, anionic Surfactants include, agitated in water. In an additional embodiment, an anionic without limitation, primary or secondary alkane Sulfonates lathering Surfactant is a Sulfate, wherein the Sulfate is, 65 of the form R1 SOM, wherein R1 is a saturated or unsatu without limitation, an alkyl sulfate or an alkyl ether sulfate. rated, branched or unbranched alkyl chain from about 8 to In a further embodiment, the sulfates include, without limi about 24 carbon atoms, and M is a water-soluble cation Such US 9,456,967 B2 41 42 as ammonium, Sodium, potassium, magnesium, trietha In an embodiment a counter cation, M, is used on the nolamine, diethanolamine and monoethanolamine. In a fur anionic Surfactant. In a further embodiment, a countercation ther embodiment, alkane sulfonate include, without limita includes, without limitation, Sodium, potassium, ammo tion, alkali metal or ammonium C 13 C 17 paraffin nium, monoethanolamine, diethanolamine, and trietha Sulfonates. In an additional embodiment, anionic Surfactants 5 nolamine. include, without limitation, alkyl Sulfo Succinates, which In an embodiment, nonionic Surfactants include, without include disodium N-octadecylsulfoSuccinamate; diammo limitation, alkyl glucosides, alkyl polyglucosides, polyhy nium lauryl Sulfo Succinate; tetrasodium N-(1,2-dicarboxy droxy fatty acid amides, alkoxylated fatty acid esters, ethyl)-N-octadecylsulfosuccinate; diamyl ester of sodium Sucrose esters, amine oxides, and mixtures thereof. Alkyl 10 glucosides and alkyl polyglucosides are condensation prod SulfoSuccinic acid; dihexyl ester of sodium SulfoSuccinic ucts of long chain alcohols, including, without limitation, C8 acid; and dioctyl esters of sodium sulfo Succinic acid. 30 alcohols, with Sugars or starches or Sugar or starch In an embodiment, taurates include, without limitation, polymers, including, without limitation, glycosides or taurine, N-alkyltaurines such as the one prepared by reacting polyglycosides and are represented by the formula (S)- dodecylamine with sodium isethionate as detailed in U.S. 15 O—R wherein S is a Sugar moiety Such as glucose, fructose, Pat. No. 2,658,072. In a further embodiment, anionic Sur mannose, and galactose; n is an integer of from about 1 to factants include, without limitation, acyl isethionates, about 1000, and R is a C830 alkyl group. In an embodiment, including, without limitation, acyl isethionates include long chain alcohols from which the alkyl group can be ammonium cocoyl isethionate, Sodium cocoyl isethionate, derived include, without limitation, decyl alcohol, cetyl Sodium lauroylisethionate, alkylglyceryl ether Sulfonates of alcohol, Stearyl alcohol, lauryl alcohol, myristyl alcohol, the form R1-OCH C(OH)H-CH, SOM, wherein R1 oleyl alcohol, and more. In a further embodiment, these is a saturated or unsaturated, branched or unbranched alkyl surfactants include, without limitation, those wherein S is a group from about 8 to about 24 carbon atoms, and M is a glucose moiety, R is a C820 alkyl group, and n is an integer water-soluble cation such as ammonium, Sodium, potas of from about 1 to about 9. Commercially available sium, magnesium, triethanolamine, diethanolamine and 25 examples of these surfactants include decyl polyglucoside monoethanolamine, Sodium cocoglyceryl ether Sulfonate, (available as APG 325 CS from Henkel) and lauryl polyg Sulfonated fatty acids of the form R1-CH(SO) COOH lucoside (available as APG 600CS and 625 CS from Hen and sulfonated methyl esters of the from R1-CH(SO)— kel). In an additional embodiment. Sucrose ester Surfactants CO O—CH, where R1 is a saturated or unsaturated, include, without limitation, Sucrose cocoate and Sucrose branched or unbranched alkyl group from about 8 to about 30 laurate. 24 carbon atoms (e.g., alpha Sulphonated coconut fatty acid In another embodiment, nonionic Surfactants include, and lauryl methyl ester); phosphates such as monoalkyl, without limitation, polyhydroxy fatty acid amide surfac dialkyl, and trialkylphosphate salts formed by the reaction of tants, more specific examples of which include glucos phosphorous pentoxide with monohydric branched or amides. In an embodiment a process for making composi unbranched alcohols having from about 8 to about 24 carbon 35 tions containing polyhydroxy fatty acid amides are atoms (e.g., Sodium mono or dilaurylphosphate, ethoxylated disclosed, for example, in G.B. Pat. Specification 809,060, monoalkyl phosphates, etc.); acylglutamates corresponding published Feb. 18, 1959, by Thomas Hedley & Co., Ltd.: to the formula R1CO N(COOH) CHCH COM U.S. Pat. No. 2,965,576, to E. R. Wilson, issued Dec. 20, wherein R1 is a saturated or unsaturated, branched or 1960; U.S. Pat. No. 2,703,798, to A. M. Schwartz, issued unbranched alkyl or alkenyl group of about 8 to about 24 40 Mar. 8, 1955; and U.S. Pat. No. 1,985,424, to Piggott, issued carbon atoms, and M is a water-soluble cation (e.g., sodium Dec. 25, 1934. In an embodiment, nonionic surfactants lauroyl glutamate and sodium cocoyl glutamate); alkanoyl include, without limitation, amine oxides, including, without sarcosinates corresponding to the formula R1CON(CH)— limitation, those corresponding to the general formula RR, CHCH COM wherein R1 is a saturated or unsaturated, RNO, wherein R contains an alkyl, alkenyl or monohy branched or unbranched alkyl or alkenyl group of about 10 45 droxy alkyl radical of from about 8 to about 18 carbon to about 20 carbon atoms, and M is a water-soluble cation atoms, from 0 to about 10 ethylene oxide moieties, and from (e.g., Sodium lauroyl sarcosinate, lauroyl sarcosine, sodium 0 to about 1 glyceryl moiety, and R and R contain from cocoyl sarcosinate, and ammonium lauroyl sarcosinate); about 1 to about 3 carbon atoms and from 0 to about 1 alkyl ether carboxylates corresponding to the formula R1 hydroxy group, e.g., methyl, ethyl, propyl, hydroxyethyl, or (OCH2CH2)x-OCH COM wherein R1 is a saturated or 50 hydroxypropyl radicals. The arrow in the formula is a unsaturated, branched or unbranched alkyl or alkenyl group conventional representation of a semipolar bond. In an of about 8 to about 24 carbon atoms, X is 1 to 10, and M is embodiment, amine oxides include, without limitation, dim a water-soluble cation (e.g., Sodium laureth carboxylate); ethyl-dodecylamine oxide, oleyldi(2-hydroxyethyl) amine acyl lactylates corresponding to the formula R1CO—O— oxide, dimethyloctylamine oxide, dimethyl-decylamine CH(CH)—COX-COM wherein R1 is a saturated or 55 oxide, dimethyl-tetradecylamine oxide, 3.6.9-trioxaheptade unsaturated, branched or unbranched alkyl or alkenyl group cyldiethylamine oxide, di(2-hydroxyethyl)-tetradecylamine of about 8 to about 24 carbon atoms, X is 3, and M is a oxide, 2-dodecoxyethyldimethylamine oxide, 3-dodecoxy water-soluble cation (e.g., Sodium cocoyl lactylate); car 2-hydroxypropyldi(3-hydroxypropyl)amine oxide, dimeth boxylates, nonlimiting examples of which include sodium ylhexadecylamine oxide. lauroyl carboxylate, sodium cocoyl carboxylate, and ammo 60 The term "amphoteric surfactant, as used herein, is also nium lauroyl carboxylate; anionic flouroSurfactants; and intended to encompass Zwitterionic Surfactants, which are natural Soaps derived from the saponification of vegetable well known to formulators skilled in the art as a subset of and/or animal fats & oils examples of which include Sodium amphoteric Surfactants. laurate, sodium myristate, palmitate, Stearate and tallowate, In an embodiment, amphoteric lathering Surfactants cocoate. In a further embodiment, a Soap is a semi-solid. In 65 include, without limitation, derivatives of aliphatic second another embodiment, a Soap includes a wax to form a solid ary and tertiary amines, including, without limitation, those Soap bar. wherein the nitrogen is in a cationic state, in which the US 9,456,967 B2 43 44 aliphatic radicals can be straight or branched chain and nonylbenzylethyldimethyl ammonium nitrate; tetrade wherein one of the radicals contains an ionizable water cylpyridinium bromide; laurylpyridinium chloride: solubilizing group, e.g., carboxy, Sulfonate, Sulfate, phos cetylpyridinium chloride; laurylpyridinium chloride; lau phate, or phosphonate. In an embodiment, amphoteric or rylisoquinolium bromide; ditallow(Hydrogenated)dimethyl Zwitterionic Surfactants include, without limitation, ammonium chloride; dilauryldimethyl ammonium chloride; betaines, Sultaines, hydroxysultaines, alkyliminoacetates, and Stearalkonium chloride. Additional cationic Surfactants iminodialkanoates, aminoalkanoates, and mixtures thereof. are disclosed in U.S. Pat. No. 4,303,543 see column 4, lines In an embodiment, betaines include, without limitation, the 58 and column 5, lines 1 42, incorporated herein by refer higher alkyl betaines, such as coco dimethyl carboxymethyl ences. Also see CTFA Cosmetic Ingredient Dictionary, 4th betaine, lauryl dimethyl carboxymethyl betaine, lauryl dim 10 Edition 1991, pages 509 514 for various long chain alkyl ethyl alphacarboxyethyl betaine, cetyl dimethyl carboxym cationic Surfactants; incorporated herein by reference. ethyl betaine, cetyl dimethyl betaine (available as Lonzaine In an embodiment, the total amount of Surfactants, includ 16SP from Lonza Corp.), lauryl bis-(2-hydroxyethyl) car ing, without limitation, a cationic Surfactant, is present in a boxymethyl betaine, oleyl dimethyl gamma-carboxypropyl Sunscreen composition or a Sunscreen composition com betaine, lauryl bis-(2-hydroxypropyl)alpha-carboxyethyl 15 bined with a bodywash, shampoo, conditioner, gel, Soap, betaine, coco dimethyl sulfopropyl betaine, lauryl dimethyl hand sanitizer, cream, lotion, spray or mousse at about 0.1 sulfoethyl betaine, lauryl bis-(2-hydroxyethyl) sulfopropyl to about 20%, or about 0.1 to about 10%, or about 0.1 to betaine, amidobetaines and amidosulfobetaines (wherein the about 5%, or about 0.5 to about 5%, or about 1 to about 10%, RCONHCCH) radical is attached to the nitrogen atom of or about 1 to about 5%, or about 0.1 to about 2%, or about the betaine), oleyl betaine (available as amphoteric Velvetex 1 to about 2% or about 0.01% w/v or about 0.1%, 0.2%, OLB-50 from Henkel), and cocamidopropyl betaine (avail 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1% or 1%, 2%, able as Velvetex BK-35 and BA-35 from Henkel). In a 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, further embodiment, Sultaines and hydroxysultaines include, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, without limitation, materials such as cocamidopropyl 25%, 26%, 27%, 28%, 29%, 30%, 35%, 40%, 45%, 50%, hydroxysultaine (available as Mirataine CBS from Rhone 25 55%, 60%, 65% or more w/v. In addition to surfactants, Poulenc). other ingredients, as described above for additives, may be In an embodiment, amphoteric Surfactants include, with included in a Sunscreen composition combined with a body out limitation, the following compounds: Cetyl dimethyl wash, shampoo, conditioner, gel, Soap, hand sanitizer, betaine (this material also has the CTFA designation cetyl cream, lotion, spray or mousse. In an embodiment, Soapless betaine); Cocamidopropylbetaine; Cocamidopropyl 30 cleansers are used in addition to, or instead of Soaps/ hydroxy Sultaine. Examples of other useful amphoteric surfactants, including, without limitation OILATUMTMAD surfactants are alkyliminoacetates, and iminodialkanoates (registered trademark, Stiefel Laboratories) AQUANILTM and aminoalkanoates of the formulas RN(CH) CO-MI (registered trademark, Person & Covey, Inc.), CETAPHILTM and RNH(CH2)COM wherein m is from 1 to 4, R is a (trademark, Galderma Laboratories, Inc.) or SPECTRO Cs-C alkyl or alkenyl, and M is H, alkali metal, alkaline 35 DERMTM (registered trademark, Draxis Pharmaceutical earth metal ammonium, alkanolammonium or imidazo Inc.), or their equivalents, may be utilized as a Soapless linium and ammonium derivatives. In a further embodiment, component in the present invention. amphoteric Surfactants include, without limitation, sodium In an embodiment, a bodywash is, without limitation, 3-dodecyl-aminopropionate, Sodium 3-dodecylaminopro SUAVE Body Wash, which has the following ingredients: pane sulfonate. In a further embodiment, N-higher alkyl 40 Water, Ammonium Lauryl Sulfate, Ammonium Laureth Sul aspartic acids include, without limitation, those produced fate, Cocamidopropyl Betaine, Fragrance, Glycerin, Hydro according to the teaching of U.S. Pat. No. 2,438,091; and the lyzed Milk Protein & Honey Extract, PEG-10 Sunflower products sold under the trade name “Miranol and described Glycerides, Cocamide MEA, Guar Hydroxypropylrimo in U.S. Pat. No. 2,528,378. In a further embodiment, ampho nium Chloride, Acrylates Copolymer, PEG-5 Cocamide, terics include, without limitation, amphoteric phosphates, 45 Helianthus Annuus (Sunflower) Seed Oil or Glycine Soja Such as coamidopropyl PG-diimonium chloride phosphate (Soybean) Oil, Tetrasoidum EDTA, Propylene Glycol, (commercially available as Monaquat PTC, from Mona Ammonium Chloride, Sodium Hydroxide, Methylchloroiso Corp.). In another embodiment, amphoacetates include, thiazolinone, Methylisothiazolinone, Titanium Dioxide (CI without limitation, disodium lauroamphodiacetate, sodium 77.891). lauroamphoacetate, and mixtures thereof. 50 The additional agents and Sunscreen active agent in a In an embodiment, a Sunscreen composition or a Sun Sunscreen composition are selected for use in a combination screen composition combined with a bodywash, shampoo, product that includes a bodywash, shampoo, conditioner, conditioner, gel, Soap, hand sanitizer, cream, lotion, spray or gel, Soap, hand sanitizer, cream, lotion, spray or mousse (a mousse include, without limitation, at least one cationic “combination product”), with a combination product applied Surfactant. In an embodiment, cationic Surfactants include, 55 to the Surface of an individual, including an individual’s skin without limitation, fatty amines, di-fatty quaternary amines, and hair. In an embodiment, application can occur during tri-fatty quaternary amines, imidazolinium quaternary washing in a Suitable or effective amount, with application amines, and combinations thereof. In a further embodiment, over part or the whole body. A shampoo or conditioner, gel. fatty amines include, without limitation, monalkyl quater Soap, hand sanitizer, cream, may be applied to hair, though nary amines such as cetyltrimethylammonium bromide. In 60 in an embodiment, the shampoo combination product may an embodiment, quaternary amine include, without limita be rinsed over part or the whole body, with a sunscreen tion, dialklamidoethyl hydroxyethylmonium methosulfate, composition adhering to the skin and hair. A selected amount In an embodiment, a Sunscreen composition or a Sunscreen of a combination product may be applied directly to the skin, composition combined with a bodywash, shampoo, condi for instance, without limitation, a lotion, spray or bodywash tioner, gel, Soap, hand sanitizer, cream, lotion, spray or 65 or may be used through intermediate application to a wash mousse include, without limitation, Stearyldimenthylbenzyl cloth, pad, sponge, or other applicator. After lathering, dirt ammonium chloride; dodecyltrimethylammonium chloride; and sloughed-off skin may be washed away by rinsing with US 9,456,967 B2 45 46 water leaving behind one or more of the Sunscreen active 120, or 150 microns into the skin. In a further embodiment agents, and in an embodiment, without limitation, a Sun penetration occurs following a single application. In a fur screen active agent encapsulated in a cellulose derived ther embodiment, penetration occurs following a single capsule. application and rinsing. In a further embodiment, penetra In an embodiment, methods for protection of skin from tion occurs with repeated applications. In a further embodi Sunlight include, applying a combination product containing ment, penetration occurs with repeated applications and a Sunscreen active agent, including, without limitation, a rinsings. Sunscreen active agent encapsulated in a cellulose derived Any additive described herein, including, without limita capsule, wherein after application of the combination prod tion, Sunscreen active agents and/or additional agents, gen uct to an individuals outer Surface, including, without 10 erally as a component of a bodywash, shampoo, conditioner, limitation, an individual’s skin, the skin is protected from gel, Soap, hand sanitizer, cream, lotion, spray or mousse, sunlight with an average SPF of at least about 1, 2, 3, 4, 5, may be used in the methods of the invention. In an embodi 6, 7, 8, 9, 10, 11, 12, 1.3, 14, 15, 16, 17, 18, 19, 20, 21, 22, ment, the Sunscreen active agents and/or additional agents is 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,38, encapsulated in a cellulose derived capsule. It is understood 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 15 that a combination product can be applied to an individuals 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, Surface, including, without limitation, an individual’s skin 71, 72,73, 74, 75 or more. In a further embodiment, the skin and/or hair while the skin and/or hair is wet or while it is dry. is protected from sunlight with an average SPF of at least In an embodiment, the combination product contains one, about 2. In a further embodiment, the skin is protected from two or more surface-treated metal oxide pigments that block sunlight with an average SPF of at least about 5. In a further ultraviolet radiation in the wavelength range of from about embodiment, the skin is protected from Sunlight with an 290 nm to about 400 nm. In an additional embodiment, the average SPF of at least about 10. In a further embodiment, one, two or more surface-treated metal oxide pigments are the skin is protected from sunlight with an average SPF of present at a combined concentration (based on the total at least about 15. In a further embodiment, the combination weight of the composition) of at least about 0.1%, 0.2%, product is applied more than once; in these cases, the SPF 25 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.25%, may be cumulative and can increase with the second wash 1.5%, 1.75%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%. 5%, 5.5%, to, e.g., an average of more than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10. 6%, 6.5%, 7%, 7.5%, 8%, 8.5%, 9%, 9.5%, 10%, 11%, 12%, 11, 12, 1.3, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 25%, 30%, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,38, 39, 40, 41, 42, 35%, 40%, 45%, 50%. 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 30 In an embodiment, a Sunscreen composition has an inner 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, refractive index of 1.5-1.7, 1.5-1.9, 1.5-2.2, 1.5-2.4 or 1.5- 75 or more. In a further embodiment, the individual rinses 2.6. In a further embodiment, a sunscreen composition has off after application of a combination product, with the SPF a non-sunscreen active agent with an inner refractive index following rinsing at least about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10. of 1.5-2.7. In a further embodiment, a sunscreen composi 11, 12, 1.3, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 35 tion has a non organic dispersed with organic Sunscreen 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,38, 39, 40, 41, 42, active agent with an inner refractive index of 1.5-2.7. In a 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, further embodiment, a Sunscreen composition has cellulose 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, derived capsules of different sizes with an inner refractive 75 or more. In an additional embodiment, a combination index of 1.5-2.7. In a further embodiment, a sunscreen product is applied once per day. In a further embodiment, a 40 composition has a mixture of cellulose derived capsules combination product is applied more than once per day, for containing different cellulose derivatives with an inner example, 2, 3, 4, or more than 4 times per day. In an refractive index of 1.5-2.7. In an embodiment, a sunscreen additional embodiment, a combination product is applied composition has an overall refractive index of 1.4-2. about every other day. In a further embodiment, the com Aspects of the present specification may also be described bination product is applied about 10, 8, 7, 6, 5, 4, 3, 2 or 1 45 as follows: time per week. 1. A Sunscreen composition comprising a Sunscreen active In an embodiment, a Sunscreen active agent, including, agent encapsulated in a cellulose derived capsule and one without limitation, a Sunscreen active agent encapsulated in or more additional agents. a cellulose derived capsule does not penetrate more than 2. A Sunscreen composition of embodiment 1, wherein a about 1, 2, 5, 7, 10, 15, 20, 25, 30, 35, 40, 45, or 50 microns 50 Sunscreen composition is combined with a bodywash, into the skin of an individual following one application of a shampoo, conditioner, gel, Soap, hand sanitizer, cream, combination product. In an additional embodiment, a Sun spray, mousse or lotion. screen active agent, including, without limitation, a Sun 3. A Sunscreen composition of embodiment 1 or 2, wherein screen active agent encapsulated in a cellulose derived a Sunscreen active agent absorbs or blocks UV radiation capsule, does not penetrate more than about 1, 2, 5, 7, 10, 15, 55 from about 290 to about 420 nm. 20, 25, 30, 35, 40, 45, 50, 60, 70, 80, 90, 100, 120, or 150 4. A Sunscreen composition of any one of embodiments 1-3, microns into the skin, even after repeated applications. wherein a Sunscreen active agent is selected from In a further embodiment a Sunscreen active agent, includ paraamino benzoates, Salicylates, cinnamates, benzophe ing, without limitation, a Sunscreen active agent encapsu nones; and miscellaneous chemicals including menthyl lated in a cellulose derived capsule is designed to penetrate 60 anthralinate and digalloyl trioleate. into the skin, and can penetrate to at least about 1, 2, 5, 7, 5. A Sunscreen composition of any one of embodiments 1-3, 10, 15, 20, 25, 30, 35, 40, 45, or 50 microns into the skin wherein a Sunscreen active agent is selected from p-amin after one application with a combination product. In a obenzoic acid, its salts and its derivatives (ethyl, isobutyl, further embodiment, a Sunscreen active agent, including, glyceryl esters; p-dimethylaminobenzoic acid); Anthra without limitation, a Sunscreen active agent encapsulated in 65 nilates (i.e., o-aminobenzoates; methyl, menthyl, phenyl, a cellulose derived capsule, penetrates more than about 1, 2, benzyl, phenylethyl, linallyl, terpinyl, and cyclohexenyl 5, 7, 10, 15, 20, 25, 30, 35, 40, 45, 50, 60, 70, 80, 90, 100, esters); Salicylates (amyl, phenyl, benzyl, menthyl, glyc US 9,456,967 B2 47 48 eryl, and dipropylene glycol esters); Cinnamic acid mate (7.5% or less, a UVB absorbing organic sunscreen), derivatives (methyl and benzyl esters, alpha-phenyl cin octyl salicylate (also called 2-ethylhexyl salicylate; 5% or namonitrile; butyl cinnamoyl pyruvate); Dihydroxycin less, a UVB absorbing organic Sunscreen), oxybenzone namic acid derivatives (umbelliferone, methylumbellifer (also called benzophenone-3; 6% or less, a UVB and UVA one, methylaceto-umbelliferone); Trihydroxycinnamic II absorbing organic Sunscreen), padimate 0 (also called acid derivatives (esculetin, methylesculetin, daphnetin, octyl dimethyl PABA; 8% or less, a UVB absorbing and the glucosides, esculin and daphnin); Hydrocarbons organic Sunscreen), phenylbenzimidazole Sulfonic acid (diphenylbutadiene, stilbene); Dibenzalacetone and ben (water soluble; 4% or less, a UVB absorbing organic Zalacetophenone; Naphtholsulfonates (sodium salts of Sunscreen), Sulisobenzone (also called benzophenone-4, 2-naphthol-3,3-disulfonic and of 2-naphthol-6,8-disulfo 10 nic acids); Dihydroxynaphthoic acid and its salts; o- and 10% or less, a UVB and UVA II absorbing organic p-Hydroxybiphenyldisulfonates; Coumarin derivatives Sunscreen), titanium dioxide (25% or less, an inorganic (7-hydroxy, 7-methyl 3-phenyl); Diazoles (2-acetyl-3- physical blocker of UVA and UVB), trolamine salicylate bromoindazole, phenyl benzoxazole, methyl naphthoX (also called triethanolamine Salicylate; 12% or less, a alole, various aryl benzothiazoles); Quinine salts (bisul 15 UVB absorbing organic sunscreen), and zinc oxide (25% fate, Sulfate, chloride, oleate, and tannate); quinoline or less, an inorganic physical blocker of UVA and UVB). derivatives (8-hydroxyquinoline salts, 2-phenylquino 11. A Sunscreen composition of any one of embodiments line); Hydroxy- or methoxy substituted benzophenones: 1-3, wherein a Sunscreen active agent included in a Uric and vilouric acids; Tannnic acid and its derivatives Sunscreen composition in Europe is selected from Cellu (e.g., hexaethylether): (Butyl carbityl) (6-propyl pipero losic derived capsules in the 400-700 nm range containing nyl) ether, Hydroquinone; BenZophenones (Oxybenzene, active sunscreen agents PABA (5% or less), camphor Sulisobenzone, Dioxybenzone, Benzoresorcinol, 2.2',4, benzalkonium methosulfate (6% or less), homosalate 4'-Tetrahydroxybenzophenone, 2,2'-Dihydroxy4,4'-dime (10% or less), benzophenone-3 (10% or less), phenylben thoxybenzophenone, OctabenZone: 4-Isopropyhldibenzo Zimidazole Sulfonic acid (8% or less, expressed as acid), ylmethane; Butylmethoxydibenzoylmethane; Etocrylene: 25 terephthalidenedicamphor sulfonic acid (10% or less, and 4-isopropyl-dibenzoylmethane; titanium dioxide, iron expressed as acid), butyl methoxydibenzoylmethane (5% oxide, zinc oxide, and mixtures thereof. Other cosmeti or less), Mexoryl XL, Neo heliopan AP, BenZophenone-9, cally-acceptable Sunscreens and concentrations (percent Uvinul T 150, Uvinul A Plus, Uvasorb HEB, Parsol SLX, by weight of the total cosmetic Sunscreen composition) benzylidene camphor sulfonic acid (6% or less, expressed include diethanolamine methoxycinnamate (10% or less), 30 as acid), octocrylene (10% or less, expressed as acid), ethyl-bis(hydroxypropyl)aminobenzoate (5% or less), polyacrylamidomethylbenzylidene camphor (6% or less), glyceryl aminobenzoate (3% or less), 4-isopropyl diben octyl methoxycinnamate (10% or less), PEG-25 PABA Zoylmethane (5% or less), 4-methylbenzylidene camphor (10% or less), isoamyl p-methoxycinnamate (10% or (6% or less), terephthalylidenedicamphor sulfonic acid less), ethylhexyl triazone (5% or less), drometrizole tri (10% or less), and Sulisobenzone (also called benzophe 35 elloxane (15% or less), diethylhexyl butamido triazone none-4, 10% or less). (10% or less), 4-methylbenzylidene camphor (4% or less), 6. A Sunscreen composition of any one of embodiments 1-3, 3-benzylidene camphor (2% or less), ethylhexyl salicylate wherein a Sunscreen active agent is a Zinc oxide. (5% or less), ethylhexyl dimethyl PABA (8% or less), 7. A Sunscreen composition of embodiment 6, wherein a Zinc benzophenone-4 (5%, expressed as acid), methylene bis oxide particle is in the range of about 2 to about 50 40 benztriazolyl tetramethylbutylphenol (10% or less), diso microns. dium phenyl dibenzimidazole tetrasulfonate (10% or less, 8. A Sunscreen composition of embodiment 6, wherein a Zinc expressed as acid), bis-ethylhexyloxyphenol methoxy oxide particle is in the range of at least about 2, 3, 4, 5, phenol triazine (10% or less), methylene bisbenzotriaz 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, olyl tetramethylbutylphenol (10% or less, also called 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 45 TINOSORB M), and bisethylhexyloxyphenol methoxy 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50 or more phenyl triazine. (10% or less, also called TINOSORBS). microns. 12. A Sunscreen composition of any one of embodiments 9. A Sunscreen composition of any one of embodiments 6-8, 1-3, wherein a Sunscreen active agent is selected from wherein a Zinc oxide is surface coated to facilitate dis silicone long-chain molecule with chromophores, e.g., persion. 50 PARASOL SLX (DSM Nutritional Products), which con 10. A Sunscreen composition of any one of embodiments tains benzyl malonate chromophores attached to specific 1-3, wherein a Sunscreen active agent included in a points on a polysiloxane chain. In an additional embodi Sunscreen composition in the United States is selected ment, a Sunscreen active agent comprises a silicone long from aminobenzoic acid (also called para-aminobenzoic chain molecule with chromophores. In an embodiment, acid and PABA; 15% or less; a UVB absorbing organic 55 Sunscreen compositions include, without limitation, octyl Sunscreen), avobenzone (also called butyl methoxy diben methoxycinnamate, octocrylene, avobenzone, titanium Zoylmethane; 3% or less, a UVA I absorbing organic dioxide, and a silicone long-chain molecule with chro Sunscreen), cinoxate (also called 2-ethoxyethyl mophores. p-methoxycinnamate; 3% or less, a UVB absorbing 13. A Sunscreen composition of embodiment 12, wherein a organic Sunscreen), decamsule, dioxybenzone (also called 60 silicon long-chain molecule is included at a concentration benzophenone-8; 3% or less, a UVB and UVA II absorb of about 0.5 to about 5%. ing organic Sunscreen), homosalate (15% or less, a UVB 14. A Sunscreen composition of embodiment 12, wherein a absorbing organic Sunscreen), menthyl anthranilate (also silicon long-chain molecule is included in a combination called menthyl 2-aminobenzoate; 5% or less, a UVA II product at a concentration of about 0.2 to about 2% (w/v). absorbing organic Sunscreen), octocrylene (also called 65 15. A Sunscreen composition of any one of embodiments 2-ethylhexyl-2-cyano-3.3 diphenylacrylate; 10% or less, a 1-15, wherein, a Sunscreen active agent is an inorganic UVB absorbing organic Sunscreen), octyl methoxycinna physical blocker of UVA solar radiation. US 9,456,967 B2 49 50 16. A Sunscreen composition of any one of embodiments 24. A Sunscreen composition of any one of embodiments 1-15, wherein a Sunscreen active agent is an inorganic 1-3, wherein a Sunscreen active agent is octyl methoxy physical blocker of UVB solar radiation. cinnamate at a concentration of about 4.5% to about 15% 17. A Sunscreen composition of any one of embodiments (w/v). 1-3, wherein a sunscreen active agent is an iron oxide or 5 25. A sunscreen composition of any one of embodiments a polymer. 1-3, wherein a Sunscreen active agent is Octocrylene at a 18. A sunscreen composition of embodiment 17, wherein a concentration of about 0.5% to about 15% (w/v). polymer is a polyethylene or a polyamide. 26. A Sunscreen composition of any one of embodiments 19. A Sunscreen composition of any one of embodiments 1-3, wherein a Sunscreen active agent is AVobenzone (e.g., 1-3, wherein a Sunscreen active agent is selected from 10 PARSOL 1789) at a concentration of about 2% to about cinnamate (e.g., Octylmethoxycinnamate (ethyl hexyl 4% (w/v), methoxycinnamate), (available under the tradename PAR 27. A Sunscreen composition of any one of embodiments SOL MCX), oxybenzone (e.g., benzophenone-3 (2-Hy 1-3, wherein a Sunscreen active agent is titanium dioxide droxy4-Methoxybenzophenone), avobenzone (4-tert-Bu 15 at a concentration of about 3% to about 9% (w/v). tyl-4'-methoxydibenzoylmethane or PARSOL 1789), 28. A Sunscreen composition of any one of embodiments octyl salicylate (2-Ethylhexyl Salicylate), octocrylene 1-3, wherein the composition contains an active agent at (2-Ethylhexyl 2-Cyano-3,3-Diphenylacrylate), methyl about 0.1 to 7.5 weight percent of octylmethoxy cinna anthranilate, and/or titanium dioxide, Tineubin or combi mate, and/or about 0.1 to 6 parts weight percent of octyl nations thereof. salicylate, and/or about 0.1 to 5 parts weight percent of 20. A Sunscreen composition of any one of embodiments oxybenzone, and/or about 1 to 10 weight percent of 1-3, wherein a Sunscreen active agent is a p-methoxycin cationic surfactant, and or about 0.01 to 1 weight percent namic acid ester. of a quaternized compound. 21. A Sunscreen composition of embodiment 20, wherein a 29. A Sunscreen composition of any one of embodiments Sunscreen active agent is selected from amyl p-methoxy 25 1-28, wherein the composition contains a firm former. cinnamate, 2-ethylhexyl p-methoxycinnamate, 2-ethoxy 30. A Sunscreen composition of any one of embodiments ethyl p-methoxycinnamate, diethanolamine p-methoxy 1-30, wherein the composition contains a preservative. cinnamate, n-octyl p-methoxycinnamate and propyl 31. A sunscreen composition of embodiment 30, wherein the p-methoxycinnamate. preservative is at a concentration of about 0.01% to about 30 1% (w/v). 22. A Sunscreen composition of any one of embodiments 32. A Sunscreen composition of any one of embodiments 1-21, wherein the composition comprises one, two, three, 1-32, wherein the SPF protection provided by a sunscreen four or more Sunscreen active agents. active agent in the composition is from about 1 to 70. 23. A Sunscreen composition of any one of embodiments 33. A Sunscreen composition of any one of embodiments 1-3, wherein a second Sunscreen active agent is selected 35 1-32, wherein the SPF protection provided by a sunscreen from p-aminobenzoic acid, Cinoxate, AVobenzone, digal active agent in the composition is from about 1 to about loyl trioleate, dioxybenzone, ethyl 4-bis(hydroxypro 50, or about 2 to about 50, or about 2 to about 40, or about pyl)aminobenzoate, glyceryl aminobenzoate, homo 2 to about 30, or about 2 to about 20, or about 2 to about Salate, lawsone with dihydroxyacetone, menthyl 10, or about 2 to about 5, or about 5 to about 25, or about anthranilate, octocrylene ethyl 2-cyano-3,3-diphenyl 40 5 to about 20, or about 5 to about 15, or about 5 to about acrylate, octyl salicylate, oxybenzone, Padimate O. phe 10. nylbenzimidazole Sulfonic acid, red petrolatum, 34. A Sunscreen composition of any one of embodiments Sulisobenzone, titanium dioxide, Zinc oxide, including 1-32, wherein the SPF protection provided by a sunscreen regular grades and grades of Such fine particle size as composition in the composition is at least 1, 2, 3, 4, 5, 6, enable the composition to be translucent or transparent, 45 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, and triethanolamine Salicylate. Additional Sunscreen com 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, pounds recognized by European authorities include N.N. 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, N-trimethyl-4-(2-oxoborn-3-ylidene methyl)anilinium 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, methyl sulfate, 3-imidazol-4-ylacrylic acid and its ethyl 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, ester, 2-phenylbenzimidazole-5-Sulfonic acid and its salts, 50 83, 84, 85, 86, 87, 88, 89,90,91, 92,93, 94, 95, 96, 97, ethoxylated 4-aminobenzoic acid, amyl 4-dimethylamin 98, 99, 100 or more. obenzoate, trimethylcyclohexyl-2-acetamidobenzoate, 35. A Sunscreen composition of any one of embodiments potassium cinnamate, 4-methoxycinnamic acid salts, pro 1-32, wherein the SPF protection provided by a sunscreen pyl 4-methoxycinnamate, Salicylic acid salts, amyl composition in the composition remains above about 1, 2, 4-methoxycinnamate, mexenone, Sulisobenzone, 2-ethyl 55 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, hexyl 2-(4-phenylbenzoyl)-benzoate, 5-methyl-2-phenyl or 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, benzoxazole, Sodium 3,4-dimethoxyphenylglyoxylate, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 1,3-bis(4-methoxyphenyl)propane-1,3-dione, 5-(3.3-dim 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, ethyl-2-norbornylidene)-3-penten-2-one, alpha-(2- 65, 66, 67, 68, 69, 70, 71, 72,73, 74, 75, 76, 77, 78, 79, Oxoborn-3-ylidene)-p-Xylene-2-sulfonic acid, alpha-(2- 60 80, 81, 82, 83, 84, 85, 86, 87, 88, 89,90, 91, 92,93, 94, Oxoborn-3-ylidene)toluene-4-Sulfonic acid and its salts, 95, 96, 97,98, 99, 100 or more 3-(4-methylbenzylidene)bornan-2-one, 3-benzyliden 36. A Sunscreen composition of any one of embodiments ebornan-2-one, alpha-cyano-4-methoxycinnamic acid 1-32, wherein the SPF protection provided by the com and its hexyl ester, 1-p-cumenyl-3-phenylpropane-1.-3- position lasts at least about 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, dione, 4-isopropylbenzyl salicylate, cyclohexyl 65 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 4-methoxycinnamate, and 1-(4-t-butylphenyl)-3-(4- 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85,90, 95, 100 methoxyphenyl)propane-1,3-dione. hours or more. US 9,456,967 B2 51 52 37. A Sunscreen composition of any one of embodiments 50. A Sunscreen composition of any one of embodiments 1-36, wherein the SPF protection provided by the com 1-49, wherein the Sunscreen composition includes an position lasts for an average of at least about 1 day, 2 days, additional agent to treat a condition Suffered by an indi 3 days, 4 days, 5 days, 6 days, 7 days, 8 days, 9 days, 10 vidual. days, 11 days, 12 days, 13 days, 14 days, after rinsing. 5 51. A sunscreen composition of embodiment 50, wherein the 38. A Sunscreen composition of any one of embodiments composition is used to treat Seborrheic dermatitis, 1-37, wherein the SPF protection provided by the com eczema, Xerosis, infestation, dyschromia, keratosis position increases after each additional application. pilaris, acne, anti-aging, sensitive skin, ephilidies, Solar 39. A sunscreen composition of embodiment 38, wherein the lentigines, photo sensitive disease, skin cancer and hX of SPF protection provided by the composition increases 10 skin cancer, melisma, auto immune, alopecia, fungal, after each additional application so that after a second, bacterial, and viral infections, protect colored or treated third, fourth, fifth, sixth, seventh, eighth, ninth, tenth, hair, bromhidrosis, malodor, dandruff, wound healing, eleventh or more washes, the SPF provided can be above insect repellant, pet shampoofskin care, lindane or similar about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 15 conditions. 17, 18, 19, or 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 52. A Sunscreen composition of any one of embodiments 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 1-3, wherein a Sunscreen active agent is titanium dioxide. 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57,58, 59, 60, 61, 53. A sunscreen composition of embodiment 52, wherein the 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, titanium dioxide has an anatase, ritile or amorphous 77,78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89,90,91, Structure. 92, 93, 94, 95, 96, 97,98, 99, 100 or more. 54. A sunscreen composition of embodiment 52, wherein the 40. A Sunscreen composition of any one of embodiments titanium dioxide is uncoated or coated. 1-40, wherein the composition includes a cationic poly 55. A sunscreen composition of embodiment 54, wherein the C. titanium dioxide is coated with aluminum compounds. 41. A sunscreen composition of embodiment 40, wherein the 25 56. A sunscreen composition of embodiment 55, wherein the cationic polymer is a quarternium or a polyguarternium. titanium dioxide is coated with aluminum oxide, alumi 42. A sunscreen composition of embodiment 29, wherein the num Stearate or aluminum laurate. film former is dimethicone and/or petrolatum. 57. A sunscreen composition of embodiment 54, wherein the 43. A sunscreen composition of embodiment 30, wherein the titanium dioxide is coated with phospholipids or silicone preservative is BHT. 30 compounds. 58. A sunscreen composition of embodiment 52, wherein the 44. A sunscreen composition of any one of embodiments titanium dioxide is micronized and has a mean primary 1-43, wherein the additional agent is an antioxidant, a particle size ranging from about 10 nm to about 50 nm. chelating agent, a liquid hydrocarbon, a foaming agent, a 59. A sunscreen composition of embodiment 52, wherein the skin nourishing Substance, Sunless tanning actives, skin 35 titanium dioxide has a micronized mean primary particle lightening actives, anti-acne actives, anti-skin wrinkling size of 15 nm. and anti-skin aging actives, vitamins, anti-inflammatory 60. A sunscreen composition of embodiment 52, wherein the actives, anesthetic actives, analgesic actives, anti-pruritic titanium dioxide is uncoated. actives, anti-microbial actives (e.g. antifungals, antibac 61. A sunscreen composition of embodiment 60, wherein the terials, and antiparasitics), anti-virals, anti-allergenics, 40 uncoated titanium dioxide has a mean particle size of medicinal actives (e.g., skin rash, skin disease and der around 35 nm to about 50 nm. matitis medications), anti-cellulite additives, insect repel 62. A sunscreen composition of embodiment 52, wherein the lant actives, antioxidants, hair growth promoters, hair composition comprises a mixture of two or more different growth inhibitors, hair bleaching agents, vitamins, particle sizes of titanium dioxide. deodorant compounds, dihydroxyacetone (DHA): glyc 45 63. A sunscreen composition of embodiment 52, wherein the eryl aldehyde; tyrosine and tyrosine derivatives Such as composition comprises a mixture of coated and uncoated malyltyrosine, tyrosine glucosinate, and ethyl tyrosine; titanium dioxide. phospho-DOPA, indoles and derivatives, skin lightening 64. A Sunscreen composition of any one of embodiments actives include, without limitation, EMBLICA (also an 1-63, wherein the composition comprises a Sunscreen antioxidant), monobenzone (a depigmenting agent), kojic 50 active agent is encapsulated. 65. A Sunscreen composition of any one of embodiments acid, arbutin, ascorbic acid and derivatives thereof (e.g., 1-63, wherein the composition comprises two or more magnesium ascorbyl phosphate or Sodium ascorbyl phos Sunscreen active agents are encapsulated. phate), and extracts (e.g., mulberry extract, placental 66. A Sunscreen composition of any one of embodiments extract). 55 1-65, wherein the composition comprises one or more 45. A Sunscreen composition of any one of embodiments Sunscreen active agents, each comprising at least about 1, 1-44, wherein the composition is applied topically. 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 46. A sunscreen composition of embodiment 45, wherein the 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, composition is sprayed. 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 47. A Sunscreen composition of any one of embodiments 60 50% or more of the sunscreen composition (w/v). 1-46, wherein an additional agent is a Surfactant. 67. A Sunscreen composition of any one of embodiments 48. A sunscreen composition of embodiment 47, wherein the 1-65, wherein the composition comprises one or more Surfactant is cationic, anionic, nonionic, Zwitterionic, Sunscreen active agents, each comprising at least about, 2. amphoteric, or any combination thereof. 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 49. A Sunscreen composition of any one of embodiments 65 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 1-48, wherein a Sunscreen active agent is organic or 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, inorganic. 50% or more of the sunscreen composition (w/v). US 9,456,967 B2 53 54 68. A Sunscreen composition of any one of embodiments at least 275 nm, at least 300 nm, at least 325 nm, at least 1-68, wherein the composition absorbs at least 1, 2, 3, 4, 350 nm, at least 375 nm, at least 400 nm, at least 425 nm, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, at least 450 nm, at least 475 nm, at least 500 nm, at least 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 525 nm, at least 550 nm, at least 575 nm, at least 600 nm, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 5 at least 625 nm, at least 650 nm, at least 675 nm, at least 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 67, 700 nm, at least 725 nm, at least 750 nm, at least 775 nm, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, at least 800 nm, at least 825 nm, at least 850 nm, at least 83, 84, 85, 86, 87, 88, 89,90,91, 92,93, 94, 95, 96, 97, 875 nm, at least 900 nm, at least 925 nm, at least 950 nm, 98.99, or 100% of incident radiation at wave lengths of at least 975 nm, at least 1000 nm or more. 290 to 320 nanometers, 10 80. A Sunscreen composition of any one of embodiments 69. A Sunscreen composition of any one of embodiments 1-79, wherein the composition comprises water, a chelat 1-68, wherein the composition absorbs at least 1, 2, 3, 4, ing agent, a moisturizing agent, a preservative, a thick 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, ening agent, a silicone containing compound, an essential 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, oil, a structuring agent, a vitamin, a pharmaceutical ingre 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 15 dient, or an antioxidant, or any combination of Such 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 67, ingredients or mixtures of Such ingredients. 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 81. A Sunscreen composition of any one of embodiments 83, 84, 85, 86, 87, 88, 89,90,91, 92,93, 94, 95, 96, 97, 1-80, wherein the composition includes, without limita 98.99, or 100% of incident radiation at wave lengths less tion, at least two, three, four, five, six, seven, eight, nine, than 290 or greater than 320 nanometers. ten, or more additional agents. 70. A Sunscreen composition of any one of embodiments 82. A sunscreen composition of embodiment 81, wherein the 1-69, wherein the ratio of sunscreen composition to additional agents have a concentration that is from about bodywash, shampoo, conditioner, lotion, gel, Soap, cream, 0.0001% to about 99.9% (w/v). hand sanitizer, spray or mousse is about 0.2,0.5,0.7 1.0, 83. A Sunscreen composition of any one of embodiments 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 25 1-82, wherein one or more additional agents are encap 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0, 3.2, 3.5, 3.7, 4.0, 4.2, 4.5, Sulated. 4.7. 5.0, 6.0, 7.0, 8.0, 9.0, 10; 12, 15, or 20 parts 84. A Sunscreen composition of any one of embodiments bodywash, shampoo, lotion, conditioner, gel, Soap, hand 1-82, wherein one or more additional agents are encap sanitizer, cream, spray or mousse to Sunscreen active Sulated and one or more additional agents are not encap agent as measured w/w. 30 Sulated. 71. A Sunscreen composition of any one of embodiments 85. A Sunscreen composition of any one of embodiments 1-70, wherein the pH of the composition is from about 6 1-82, wherein one or more additional agents are not to about 8. encapsulated. 72. A Sunscreen composition of any one of embodiments 86. A Sunscreen composition of any one of embodiments 1-70, wherein the pH of the composition is from about 6.7 35 1-85, wherein the composition increases the protection of to about 7.5. pH to 4.0 to about 10. an individual to which the composition is applied by at 73. A Sunscreen composition of any one of embodiments least 0.1 times greater, 0.2 times greater, 0.3 times greater, 1-70, wherein the pH of the composition is at least 1, 2, 0.4 times greater, 0.5 times greater, 0.6 times greater, 0.7 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14. times greater, 0.8 times greater, 0.9 times greater, 1 times 74. A Sunscreen composition according to any one of 40 greater, 1.25 times greater, 1.5 times greater, 1.75 times embodiments 1-73, wherein a cellulose derived capsule greater, 2 times greater, 2.25 times greater, 2.5 times contains one Sunscreen active agent. greater, 2.75 times greater, 3 times greater, 3.25 times 75. A Sunscreen composition according to any one of greater, 3.5 times greater, 3.75 times greater, 4 times embodiments 1-73, wherein a cellulose derived capsule greater, 4.25 times greater, 4.5 times greater, 4.75 times contains two or more Sunscreen active agents. 45 greater, 5 times greater, 5.25 times greater, 5.5 times 76. A Sunscreen composition according to any one of greater, 5.75 times greater, 6 times greater, 6.25 times embodiments 1-73, wherein the cellulose derived capsule greater, 6.5 times greater, 6.75 times greater, 7 times is flexible. greater, 7.25 times greater, 7.5 times greater, 7.75 times 77. A Sunscreen composition according to any one of greater, 8 times greater, 8.25 times greater, 8.5 times embodiments 1-73, wherein the cellulose derived capsule 50 greater, 8.75 times greater, 9 times greater, 9.25 times has a high load rate. greater, 9.5 times greater, 9.75 times greater, 10 times 78. A Sunscreen composition according to any one of greater, 11 times greater, 12 times greater, 13 times embodiments 1-77, wherein the cellulose derived capsule greater, 14 times greater, 15 times greater, 16 times is comprised of hydroxypropylcellulose, hydroxypropyl greater, 17 times greater, 18 times greater, 19 times methylcellulose, ethylcellulose, carboxymethylcellulose 55 greater, 20 times greater, 21 times greater, 22 times or any derivatives therefrom. greater, 23 times greater, 24 times greater, 25 times 79. A Sunscreen composition according to any one of greater, 30 times greater, 35 times greater, 40 times embodiments 1-78, wherein the cellulose derived capsule greater, 45 times greater, 50 times greater, 55 times has a diameter of about 400 nm to about 700 nm. In an greater, 60 times greater, 6.5 times greater, 70 times additional embodiment, a cellulose derived capsule has a 60 greater, 75 times greater, 80 times greater, 85 times diameter of about 400 nm to about 650 nm, about 400 nm. greater, 90 times greater, 95 times greater, 100 times to about 600 nm, about 400 nm to about 550 nm, about greater than a Sunscreen active agent is not encapsulated 400 nm to about 500 nm, about 400 nm to about 450 nm. 87. A Sunscreen composition of any one of embodiments In a further embodiment, a cellulose derived capsule has 1-86, wherein the concentration of a sunscreen active a diameter of at least 25 nm, at least 50 nm, at least 75 nm, 65 agent that is a UVA absorber is from of about 1% to about at least 100 nm, at least 125 nm, at least 150 nm, at least 40%, or about 2% to about 20%, or about 2% to about 175 nm, at least 200 nm, at least 225 nm, at least 250 nm, 10%, or about 5% to about 10%, or about 1%, 2%, 3%, US 9,456,967 B2 55 56 4%, 5%, 6%, 7%, 7.4%, 7.5%, 7.6%, 8%, 9%, 10%, 11%, 99. A sunscreen composition of embodiment 97, wherein the 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, anti-acne active is encapsulated in a cellulose derived 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, capsule. 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39% or 40% 100. A sunscreen composition of embodiment 97, wherein (w/v). the anti-acne active is not encapsulated in a cellulose 88. A Sunscreen composition of any one of embodiments derived capsule. 1-86, wherein the concentration of a sunscreen active 101. A Sunscreen composition of any one of embodiments agent that is a UVB absorber is from of about 1% to about 1-92, wherein the additional agent is an anti-skin wrin 40%, or about 2% to about 20%, or about 2% to about kling active. 10 102. A sunscreen composition of embodiment 101, wherein 10%, or about 5% to about 10%, or about 1%, 2%, 3%, the anti-skin wrinkling active is selected from cosmetic 4%, 5%, 6%, 7%, 7.4%, 7.5%, 7.6%, 8%, 9%, 10%, 11%, products that contain hydroxy acids, retinol, retinoic, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, retinol palmitate, a derivative of vitamin A, (or its stron 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, ger, prescribed version Retin-A and Renova), bicyclic 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39% or 40% 15 aromatic compounds with retinoid-type activity and more. (w/v). 103. A sunscreen composition of embodiment 101 wherein 89. A Sunscreen composition of any one of embodiments the anti-skin wrinkling active is encapsulated in a cellu 1-86, wherein the concentration of a sunscreen active lose derived capsule. agent is from of about 1% to about 40%, or about 2% to 104. A sunscreen composition of embodiment 101 wherein about 20%, or about 2% to about 10%, or about 5% to the anti-skin wrinkling active is not encapsulated in a about 10%, or about 1%, 2%, 3%, 4%, 5%, 6%, 7%, 7.4%, cellulose derived capsule. 7.5%, 7.6%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 105. A Sunscreen composition of any one of embodiments 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 1-92, wherein the additional agent is a botulinum toxin 26%. 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, serotype A. 36%, 37%, 38%, 39% or 40% (w/v). 25 106. A sunscreen composition of embodiment 105, wherein 90. A Sunscreen composition of any one of embodiments an anti-skin aging or anti-wrinkling additional agents are 1-89, wherein the cellulose derived capsule is prepared so bicyclic aromatic compounds, compounds which have as to experience breakage in the range of about 0, 0.1, 0.5, retinoid-type activity, free-radical scavengers, hydroxy or 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, keto acids or derivatives thereof. 30 107. A sunscreen composition of embodiment 106, wherein 19, 20, 21, 22, 23, 24, 25, 30, 35, 40, 45, 50, 55, 60, 65, the free-radical Scavengers are selected from a-tocoph 70, 75, 80, 85, 90 or 95% to about 0.50.1, 0.5, 1, 2, 3, 4, erol, superoxide dismutase, ubiquinol or certain metal 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, chelating agents. 22, 23, 24, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 108. A sunscreen composition of embodiment 106, wherein 85, 90 or 95% after application. 35 hydroxyl acids are selected from C-hydroxy acids such as 91. A Sunscreen composition of any one of embodiments lactic acid and glycolic acid or B-hydroxy acids Such as 1-89, wherein the cellulose derived capsule is prepared so salicylic acid and Salicylic acid derivatives such as the as to experience breakage in response to conditions that octanoyl derivative; other hydroxy acids and keto acids occur on the skin or hair. include, without limitation, malic, citric, mandelic, tar 92. A Sunscreen composition of any one of embodiments 40 taric or glyceric acids or the salts, amides or esters thereof. 1-89, wherein the cellulose derived capsule is prepared so 109. A Sunscreen composition of any one of embodiments as to experience breakage in response to conditions that 1-104, wherein an anti-skin aging or anti-wrinkling addi occur on the skin or hair in a time release or controlled tional agents are sulfur-containing D and L amino acids a. and their derivatives and salts, phospholipids (e.g., dis 93. A Sunscreen composition of any one of embodiments 45 tearoyl lecithin phospholipid), fatty acids, fatty alcohols, 1-92, wherein the additional agent is a vitamin. cholesterol, plant sterols, phytic acid, lipoic acid; lyso 94. A sunscreen composition of embodiment 93, wherein the phosphatidic acid, and skin peel agents (e.g., phenol and vitamin is selected from Vitamin A and derivatives thereof the like), and mixtures thereof. (including, for example, retinol, see anti-wrinkling 110. A Sunscreen composition of any one of embodiments actives), ascorbic acid (Vitamin C and derivatives), Vita 50 1-92, wherein the additional agent is an anti-inflammatory min B (e.g., riboflavin, vitamin B), biotin, Vitamin D (all active. forms), Vitamin E and derivatives thereof such as tocoph 111. A sunscreen composition of embodiment 110, wherein eryl acetate, beta-carotene, panthothenic acid, vitamin C, the anti-inflammatory active is selected from corticoster vitamin E and coenzyme Q-10 more. oids such as hydrocortisone, hydroxyltriamcinolone, 95. A sunscreen composition of embodiment 93, wherein the 55 alpha-methyl dexamethasone, dexamethasone-phosphate, vitamin is encapsulated in a cellulose derived capsule. beclomethasone dipropionates, clobetasol Valerate, des 96. A sunscreen composition of embodiment 93, wherein the onide, desoxymethasone, desoxycorticosterone acetate, vitamin is not encapsulated in a cellulose derived capsule. dexamethasone, dichlorisone, diflorasone diacetate, dif 97. A Sunscreen composition of any one of embodiments lucortolone Valerate, fluadrenolone, fluclorolone 1-92, wherein the additional agent is an anti-acne active. 60 acetonide, fludrocortisone, flumethasone pivalate, flu 98. A sunscreen composition of embodiment 97, wherein the osinolone acetonide, fluocinonide, flucortine butylesters, anti-acne active is selected from benzoyl peroxide, eryth fluocortolone, fluprednidene (flu prednylidene) acetate, romycin, clindamycin phosphate, 5,7-dichloro-8-hy flurandrenolone, halcinonide, hydrocortisone acetate, droxyquinoline, resorcinol, resorcinol acetate, Salicylic hydrocortisone butyrate, methylprednisolone, triamcino acid, azaleic acid, long chain dicarboxylic acids, Sulfur, 65 lone acetonide, cortisone, cortodoxone, flucetonide, Zinc, various natural agents such as those derived from fludrocortisone, difluorosone diacetate, fluradrenolone, green tree, and more. fludrocortisone, diflurosone diacetate, fluradrenolone US 9,456,967 B2 57 58 acetonide, medrysone, amcinafel, amcinafide, betametha inate, 1-beta-glycyrrhetic acid, Stearyl glycyrrhetinate, Sone and the balance of its esters, chloroprednisone, and 3-stearyloxy-glycyrrhetinic acid, disodium 3-Succi chlorprednisone acetate, clocortelone, clescinolone, nyloxy-beta-glycyrrhetinate, and combinations thereof. dichlorisone, diflurprednate, flucloronide, flunisolide, 116. A Sunscreen composition of any one of embodiments fluoromethalone, fluperolone, fluprednisolone, hydrocor 1-92, wherein the additional agent is an anesthetic. tisone Valerate, hydrocortisone cyclopentylpropionate, 117. A sunscreen composition of embodiment 116, wherein hydrocortamate, meprednisone, paramethasone, predni the anesthetic is selected from butamben picrate, lido Solone, prednisone, beclomethasone dipropionate, triam caine, Xylocalne, benzocaine, bupivacaine, chlorprocaine, cinolone, and mixtures thereof. dibucaine, etidocaine, mepivacaine, tetracaine, dyclonine, 112. A sunscreen composition of embodiment 110, wherein 10 hexylcaine, procaine, cocaine, ketamine, pramoxine, phe the anti-inflammatory active is selected from nonsteroidal nol, and pharmaceutically acceptable salts thereof. anti-inflammatory agents include, without limitation, oxi 118. A sunscreen composition of embodiment 116, wherein cams (e.g., piroXicam, isoxicam, tenoxicam, Sudoxicam, the anesthetic is encapsulated in a cellulose derived CP-14.304); Salicylates (e.g., aspirin, disalcid, benorylate, capsule. trilisate, Safapryn, Solprin, diflunisal, fendosal); acetic 15 119. A sunscreen composition of embodiment 116, wherein acid derivatives (e.g., diclofenac, fenclofenac, indometha the anesthetic is not encapsulated in a cellulose derived cin, Sulindac, tolmetin, isoxepac, furofenac, tiopinac, capsule. Zidometacin, acematacin, fentiazac, Zomepirac, clin 120. A Sunscreen composition of any one of embodiments danac, oxepinac, felbinac, ketorolac); fenamates (e.g., 1-92, wherein the additional agent is an analgesic. mefenamic, meclofenamic, flufenamic, niflumic, tolfe 121. A sunscreen composition of embodiment 120, wherein namic acids); propionic acid derivatives (e.g., ibuprofen, the analgesic is selected from dyclonine hydrochloride, naproxen, benoxaprofen, flurbiprofen, ketoprofen, feno aloe Vera, fentanyl, capsaicin, and the like. In an embodi profen, fenbufen, indopropfen, pirprofen, carprofen, ment, anti-pruritic actives include, without limitation, Oxaprozin, pranoprofen, miroprofen, tioxaprofen, Supro alclometasone dipropionate, betamethasone Valerate, and fen, alminoprofen, tiaprofenic), pyrazoles (e.g., phenylb 25 isopropyl myristate MSD. In an embodiment, anti-micro utaZone, oxyphenbutaZone, feprazone, azapropaZone, bial actives include, without limitation, antifungal, anti trimethaZone); and combinations thereof as well as any bacterial, and antiseptic compounds. Antifungal com dermatologically acceptable salts or esters of thereof, pounds include, but are not limited to, compounds such as COX-2 inhibitors including AZD 3582 (AstraZeneca and imidazole antifungals. Specific antifungals include buto NicOx), Celecoxib (Pharmacia Corp.) (4-5-(4-methyl 30 couazole nitrate, miconazole, econazole, ketoconazole, phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-ylbenzenesul oxiconizole, haloprogin, clotrimazole, and butenafine fonamide), Meloxicam (Boehringer Ingelheim Pharma HCl, naftifine, terbinafine, ciclopirox, and tolnaftate. ceuticals) (4-hydroxy-2-methyl-N-(5-methyl-2- Antibacterial and antiseptic compounds include phenol thiazolyl)-2H-1,2GW-406381 (GlaxoSmithkline), TEA complex, mupirocin, triclosan, chlorocresol, Etoricoxib (MERCK & Co.), Rofecoxib (MERCK & Co.) 35 chlorbutol, iodine, clindamycin, CAE (Anjinomoto Co., (4-4-(methylsulfonyl)phenyl-3-phenyl-2(5H)-fura Inc., containing DL-pyrrolidone Carboxylic acid salt of none), Lumiracoxib (Novartis Pharma AG), Valdecoxib L-Cocoyl Arginine Ethyl Ester), povidone-iodine, poly (Pharmacia Corp.) (4-(5-methyl-3-phenyl-4-isox-azolyl) myxin b sulfate-bacitracin, zinc-neomycin Sulfate-hydro benzenesulfonamide), and Etodolac (Wyeth Ayerst Labo cortisone, chloramphenicol, methylbenzethonium chlo ratories) ((+) 1,8-diethyl-1,3,4,9-tetrahydropyrano-3,4- 40 ride, and erythromycin and antiseptics (e.g., blacid). benzalkonium chloride, benzethonium chloride, chlo 113. A sunscreen composition of embodiment 110, wherein rhexidine gluconate, mafenide acetate, nitrofuraZone, the anti-inflammatory active is encapsulated in a cellulose nitromersol, antimicrobial deodorant compounds, anti derived capsule. parasitics, and lindane. 114. A sunscreen composition of embodiment 110, wherein 45 122. A sunscreen composition of embodiment 120, wherein the anti-inflammatory active is not encapsulated in a the analgesic is encapsulated in a cellulose derived cap cellulose derived capsule. Sule. 115. A sunscreen composition of embodiment 114, wherein 123. A sunscreen composition of embodiment 120, wherein an additional agent is selected from candelilla wax, bis the analgesic is not encapsulated in a cellulose derived abolol (e.g., alphabisabolol), aloe Vera, plant sterols (e.g., 50 capsule. phytosterol), Manjistha (extracted from plants in the 124. A Sunscreen composition of any one of embodiments genus Rubia, particularly Rubia Cordifolia), and Guggal 1-92, wherein the additional agent is an antimicrobial and (extracted from plants in the genus Commiphora, particu antifungal. larly Commiphora Mukul), kola extract, chamomile, red 125. A sunscreen composition of embodiment 124, wherein clover extract, Sea whip extract, anise oil, garlic oil, 55 the antimicrobial and antifungal is selected from beta.- ginger extract, vasoconstrictors such as phenylephrine lactam drugs, quinolone drugs, ciprofloxacin, norfloxacin, hydrochloride, compounds of the Licorice (the plant tetracycline, amikacin, 2.4,4'-trichloro-2'-hydroxy diphe genus/species Glycyrrhiza glabra) family, including gly nyl ether, 3,4,4-trichlorocarbanilide, phenoxyethanol, cyrrhetic acid, glycyrrhizic acid, and derivatives thereof phenoxy propanol, phenoxyisopropanol, doxycycline, (e.g., salts and esters). Suitable salts of the foregoing 60 capreomycin, chlorhexidine, chlortetracycline, oxytetra compounds include metal and ammonium salts. Suitable cycline, ethambutol, hexamidine isethionate, metronida esters include C-C Saturated or unsaturated esters of the Zole, pentamidine, gentamicin, kanamycin, lineomycin, acids, preferably Co-C, more preferably C-C. Spe methacycline, methenamine, minocycline, neomycin, cific non-limiting examples of the foregoing include oil netilmicin, paromomycin, streptomycin, tobramycin, Soluble licorice extract, the glycyrrhizic and glycyrrhetic 65 miconazole, tetracycline hydrochloride, erythromycin, acids themselves, mono ammonium glycyrrhizinate, Zinc erythromycin, erythromycin estolate, erythromycin monopotassium glycyrrhizinate, dipotassium glycyrrhiz Stearate, amikacin Sulfate, doxycycline hydrochloride, US 9,456,967 B2 59 60 capreomycin Sulfate, chlorhexidine gluconate, chlorhexi cortisone, Sulfur, menthol, psoralen, pramoxine hydro dine hydrochloride, chlortetracycline hydrochloride, chloride anthralin, and methoXSalen; steroids, such as Oxytetracycline hydrochloride, clindamycin hydrochlo 2-(acetyloxy)-9-fluoro-1'2',3',4'-tetrahydro-11-hydroxy ride, ethambutol hydrochloride, metronidazole hydro pregna-1,4-dieno 16,17-bnaphthalene-3,20-dione and chloride, pentamidine hydrochloride, gentamicin Sulfate, 21-chloro-9-fluoro-1,2',3',4'-tetrahydro-11b-hydroxy kanamycin Sulfate, lineomycin hydrochloride, methacy pregna-1,4-dieno 16Z, 17-bnaphthalene-3,20-dione, cline hydrochloride, methenamine hippurate, meth camphor, menthol, benzocaine, butamben picrate, dibu enamine mandelate, minocycline hydrochloride, neomy caine, dibucaine hydrochloride, dimethisoquin hydro cin Sulfate, netilmicin Sulfate, paromomycin Sulfate, chloride, dyclonine hydrochloride, lidocaine, metacresol, streptomycin Sulfate, tobramycin Sulfate, miconazole 10 lidocaine hydrochloride, pramoxine hydrochloride, tetra hydrochloride, amanfadine hydrochloride, amanfadine caine, tetracaine hydrochloride, benzyl alcohol, camphor Sulfate, octopirox, parachlorometa Xylenol, nystatin, tol ated metacresol, juniper tar, phenol, phenolate Sodium, naftate, Zinc pyrithione and clotrimazole. resorcinol, diphenhydramine hydrochloride, 126. A Sunscreen composition of embodiment 124, wherein tripelennamine hydrochloride, hydrocortisone, a corticos the antimicrobial and antifungal is encapsulated in a 15 teroid, or hydrocortisone acetate. cellulose derived capsule. 140. A sunscreen composition of embodiment 137, wherein 127. A sunscreen composition of embodiment 124, wherein the dermatological condition is encapsulated in a cellulose the antimicrobial and antifungal is not encapsulated in a derived capsule. cellulose derived capsule. 141. A sunscreen composition of embodiment 137, wherein 128. A Sunscreen composition of any one of embodiments the dermatological condition is not encapsulated in a 1-92, wherein the additional agent is an anti-viral. cellulose derived capsule. 129. A sunscreen composition of embodiment 128, wherein 142. A Sunscreen composition of any one of embodiments the anti-viral is selected from limitatin, metal salts, silver 1-92, wherein the additional agent is an anticellulite nitrate, copper Sulfate, iron chloride, organic acids, malic active. acid, Salicylic acid. Succinic acid and benzoic acid. 25 143. A sunscreen composition of embodiment 142, wherein 130. A sunscreen composition of embodiment 128, wherein the anticellulite active is selected from isobutylmethylx the anti-viral is encapsulated in a cellulose derived cap anthine, caffeine, theophylline, theobromine, aminophyl Sule. line, yohimbine, and mixtures thereof. 131. A sunscreen composition of embodiment 129, wherein 144. A Sunscreen composition of embodiment 142, wherein the anti-viral is not encapsulated in a cellulose derived 30 the anti-allergenics is encapsulated in a cellulose derived capsule. capsule. 132. A sunscreen composition of any one of embodiments 145. A sunscreen composition of embodiment 142, wherein 1-92, wherein the additional agent is an anti-allergenics. the anti-allergenics is not encapsulated in a cellulose 133. A sunscreen composition of embodiment 132, wherein derived capsule. the anti-allergenics is an antihistamine. 35 146. A Sunscreen composition of any one of embodiments 134. A sunscreen composition of embodiment 132, wherein 1-92, wherein the additional agent treats hair loss. the antihistamine is selected from diphenhydramine 147. A sunscreen composition of embodiment 146, wherein (Benadryl), chlorpheniramine, tripelennamine, prometh the hair loss treatment active is selected from potassium azine, clemastine, doxylamine, benadryl and more. In a channel openers or peripheral vasodilators such as further embodiment, H-non-sedating antihistamines 40 minoxidil, diazoxide, and compounds such as N*-cyano include, without limitation, astemizole, terfenadine, lor N-(tert-pentyl)-N'-3-pyridinyl-guanidine; vitamins, such atadine, cimetadine, cromolyn, famotidine, nizatidine, as vitamin E and vitamin C, and derivatives thereof such and ranitidine. as vitamin E acetate and Vitamin C palmitate; hormones, 135. A sunscreen composition of embodiment 132, wherein Such as erythropoietin, prostaglandins, such as prosta the anti-allergenics is encapsulated in a cellulose derived 45 glandin El and prostaglandin F2-alpha; fatty acids, such capsule. as oleic acid; diuretics such as spironolactone; heat shock 136. A sunscreen composition of embodiment 132, wherein proteins (“HSP”), HSP 27.d HSP 72; calcium channel the anti-allergenics is not encapsulated in a cellulose blockers, such as Verapamil HCL, nifedipine, and dilti derived capsule. azemamiloride; cyclosporin and Fk-506; 5 alpha-reduc 137. A Sunscreen composition of any one of embodiments 50 tase inhibitors such as finasteride; EGF, IGF and FGF; 1-92, wherein the additional agent treats dermatological transforming growth factor beta; tumor necrosis factor; conditions. non-steroidal anti-inflammatory agents such as benox 138. A sunscreen composition of embodiment 137, wherein aprofen; retinoids such as tretinoin; cytokines. Such as the dermatological condition is selected from psoriasis, IL-6, IL-1 alpha, and IL-1 beta; cell adhesion molecules acne, eczema, and other skin conditions due to disease, 55 Such as ICAM; glucorcorticoids such as betametaSone; pathology, accident, and the like. botanical extracts such as aloe, clove, ginseng, rehmannia, 139. A sunscreen composition of embodiment 137, wherein Swertia, Sweet orange, Zanthoxylum, Serenoa repens (saw the treatment of a dermatological condition is selected palmetto), Hypoxis rooperi, stinging nettle, pumpkin from o-amino-p-toluenesulfonamide monoacetate; der seeds, and rye pollen; other botanical extracts including matitis relief agents, such as the active steroid amcinon 60 Sandlewood, red beet root, chrysanthemum, rosemary, ide, diflorasone diacetate, and hydrocortisone; diaper rash burdock root, Kalium Phosphoricum D2, Azadirachta relief agents, such as methylbenzethonium chloride and indica D2, and Joborandi DI; ketoconazole and elubiol; the like; herpes treatment drugs, such as O-(2-hydroxy streptomycin; cycloheximide; acetazolamide; benoxapro ethoxy)methylguanine; psoriasis, Seborrhea and scabi fen, cortisone; diltiazem; hexachlorobenzene, hydantoin: cide agents, such as shale oil and derivatives thereof, 65 nifedipine; penicillamine; phenothaiazines; pinacidil; elubiol, ketoconazole, coal tar and petroleum distillates, psoralens, Verapamil; zidovudine; alpha-glucosylated Salicylic acid, Zinc pyrithione, selenium Sulfide, hydro rutin: quercetin, isoquercitrin, hespeddin, maringin, and US 9,456,967 B2 61 62 methylhesperidin, and flavonoids and transglycosidated octachlorohydrate, aluminum sesquichlorohydrate, alu derivatives, minoxidil, 6-(1-piperdinyl)-2,4-pyrimidin minum sesquichlorohydrex PG, aluminum chlorohydrex ediamine-3-oxide, N'-cyano-N-(tert-pentyl)-N'-3-pyridi PEG, aluminum zirconium octachlorohydrex glycine nyl-guanidine, finasteride, retinoids and derivatives complex, aluminum zirconium pentachlorohydrex gly thereof, ketoconazole, elubiol, trypsin; vitamins such as cine complex, aluminum zirconium tetrachlorohydrex alpha-tocophenol (vitamin E) and derivatives thereof such glycine complex, aluminum zirconium trichlorohydrex as tocophenol acetate and tocophenol palmitate; antine glycine complex, aluminum chlorohydrex PG, Zirconium oplastic agents, such as doxorubicin, cyclophosphamide, chlorohydrate, aluminum dichlorohydrate, aluminum chlormethine, methotrexate, fluorouracil, Vincristine, dichlorohydrex PEG, aluminum dichlorohydrex PG, alu daunorubicin, bleomycin and hydroxycarbamide; antico 10 minum sesquichlorohydrex PG, aluminum chloride, alu agulants, such as heparin, heparinoids, coumaerins, detran minum zirconium pentachlorohydrate, chlorophyllin cop and indandiones; antithyroid drugs, such as iodine, thio per complex, aluminum chloride, aluminum chloride uracils and carbimazole; lithium and lithium carbonate; hexahydrate, and methylbenzethonium and mixtures interferons, such as interferon alpha, interferon alpha-2a thereof and interferon alpha-2b; retinoids, such as retinol (vitamin 15 A), isotretinoin: glucocorticoids such as betamethasone, 157. A sunscreen composition of embodiment 154, wherein and dexamethoSone; antihyperlipidaemic drugs, such as the deodorant is a bacteriostatic quaternary aluminum triparanol and clofibrate; thallium; mercury; albendazole; compound. allopurinol; amiodarone; amphetamines; androgens; bro 158. A sunscreen composition of embodiment 156, wherein mocriptine; butyrophenones; carbamazepine; the aluminum compound is selected from cetyl trimethyl cholestyramine; cimetidine, clofibrate; danazol; desipra ammonium bromide, cetyl pyridinium chloride, benze mine; dixyrazine; ethambutol; etionamide; fluoxetine; thonium chloride, diisobutylbenzoxyethoxyethyldimeth gentamicin, gold salts; hydantoins; ibuprofen; impramine; ylbenzyl ammonium chloride, sodium N-lauryl sarcosine, immunoglobulins; indandiones; indomethacin; intracon Sodium N-polymethyl sarcosine, lauroyl sarcosine, azole; levadopa; maprotiline; methysergide; metoprolol; 25 N-myristolylglycine, potassium N-lauroyl sarcosine, and metyrapone; nadolol; nicotinic acid; potassium thiocya Stearyl trimethyl ammonium chloride; alkali metal car nate; propranolol; pyridostimine; Salicylates; Sulfasala bonates and bicarbonates, and ammonium and tetralky Zine; terfenadine; thiamphenicol; thiouracils; trimethadi lammonium carbonates and bicarbonates. one; troparanol; Valproic acid; and mixtures thereof. 159. A sunscreen composition of embodiment 154, wherein Preferred hair growth inhibitory agents include serine 30 the deodorant is encapsulated in a cellulose derived proteases, retinol, isotretinoin, betamethoisone, alpha capsule. tocophenol or mixtures thereof. 148. A sunscreen composition of embodiment 146, wherein 160. A sunscreen composition of embodiment 154, wherein the hair growth stimulant is encapsulated in a cellulose the deodorant agent is not encapsulated in a cellulose derived capsule. 35 derived capsule. 149. A sunscreen composition of embodiment 146, wherein 161. A Sunscreen composition of any one of embodiments the hair growth stimulant is not encapsulated in a cellu 1-92, wherein the additional agent is an antioxidant. lose derived capsule. 162. A sunscreen composition of embodiment 161, wherein 150. A Sunscreen composition of any one of embodiments the antioxidants is selected from propyl, octyl and dode 1-92, wherein the additional agent is a hair bleaching 40 cyl esters of gallic acid, butylated hydroxyanisole, buty agent. lated hydroxytoluene (BHT), nordihydroguaiaretic acid, 151. A sunscreen composition of embodiment 150, wherein Vitamin A, ascorbic acid and its salts, ascorbyl esters of the hair bleaching agent is selected from perborate or fatty acids, ascorbic acid derivatives, magnesium ascorbyl persulfate salts. phosphate, Sodium ascorbyl phosphate, ascorbyl Sorbate, 152. A sunscreen composition of embodiment 150, wherein 45 tocopherol, tocopherol acetate, other esters of tocopherol, the hair bleaching agent is encapsulated in a cellulose tocotrienols and their esters, 6-hydroxy-2,5,7,8-tetram derived capsule. ethylchroman-2-carboxylic acid, uric acid and its salts 153. A sunscreen composition of embodiment 150, wherein and alkyl esters, Sorbic acid and its salts, lipoic acid, the hair bleaching agent is not encapsulated in a cellulose amines, N,N-diethylhydroxylamine, amino-guanidine, derived capsule. 50 Sulfhydryl compounds, glutathione, N-acetyl cysteine, 154. A Sunscreen composition of any one of embodiments dihydroxy fumaric acid and its salts, lycine pidolate, 1-92, wherein the additional agent is a deodorant. arginine pilolate, nordihydroguaiaretic acid, biofla 155. A sunscreen composition of embodiment 154, wherein vonoids, curcumin, lysine, methionine, proline, SuperoX the deodorant is selected from astringent salts and bioac ide dismutase, silymarin, tea extracts, grape skin/seed tive compounds. 55 extracts, melanin, and rosemary extracts. 156. A sunscreen composition of embodiment 155, wherein 163. A sunscreen composition of embodiment 161, wherein the astringent salts are selected from organic and inor the antioxidants is encapsulated in a cellulose derived ganic salts of aluminum, Zirconium, Zinc, Sulfate, chlo capsule. ride, chlorohydroxide, alum, formate, lactate, benzyl Sul 164. A sunscreen composition of embodiment 161, wherein fonate or phenyl sulfonate, aluminum chloride, aluminum 60 the antioxidants is not encapsulated in a cellulose derived halides, aluminum hydroxyhalides, Zirconyl oxyhalides, capsule. Zirconyl hydroxyhalides, aluminum bromohydrate, potas 165. A Sunscreen composition of any one of embodiments sium alum, sodium aluminum chlorohydroxy lactate, alu 1-92, wherein the additional agent is a photostable anti minum Sulfate, aluminum chlorohydrate, aluminum-zir oxidant. conium tetrachlorohydrate, an aluminum-zirconium 65 166. A sunscreen composition of embodiment 165, wherein polychlorohydrate complexed with glycine, aluminum the photostable antioxidant is encapsulated in a cellulose Zirconium trichlorohydrate, aluminum-zirconium derived capsule. US 9,456,967 B2 63 64 167. A sunscreen composition of embodiment 165, wherein anhydride?pentaerythritol/neopentyl glycol?palmitic acid the photostable antioxidant is not encapsulated in a cel copolymer, benzoin extract, butadiene/acrylonitrile copo lulose derived capsule. lymer, butylated urea-formaldehyde resin, butylbenzoic 168. A Sunscreen composition of any one of embodiments acid/phthalic anhydride trimethylolethane copolymer, 1-92, wherein the additional agent is an insect repellent. 5 butyl ester of ethylene maleic anhydride copolymer, butyl 169. A sunscreen composition of embodiment 168, wherein ester of PVM/MA copolymer, calcium carrageenan, cal the insect repellent is selected from N,N-Diethyl-m-tolu cium/sodium PVM/MA copolymer, carboxymethyl amide, dimethyl phthalate, ethyl hexanediol, indalone, hydroxyethyl cellulose, cellulose gum, collodion, copal, citronella oil, lemon grass oil, limonene, rosemary oil and corn starch/acrylamide/sodium acrylate copolymer, eucalyptus oil, di-n-propylisocinchoronate, bicyclohep 10 damar, diethylene glycolamine/epichlorohydrin/pipera tene, dicarboximide and tetrahydrofuraldehyde. zine copolymer, DMJ-IF, dodecanedoic acid/cetearyl 170. A sunscreen composition of embodiment 168, wherein alcoholglycol copolymer, ethylcellulose, ethylene? acry the insect repellent is encapsulated in a cellulose derived late copolymer, ethylene/maleic anhydride copolymer, capsule. ethylene/vinyl acetate copolymer, ethyl ester of PVM/ 171. A sunscreen composition of embodiment 168, wherein 15 fvlA copolymer, flexible collodian, gum benzoin, gutta the insect repellent is not encapsulated in a cellulose percha, hydroxybutyl methylcellulose, hydroxyethylcel derived capsule. lulose, hydroxyethyl ethyl cellulose, hydroxypropylcellu 172. A Sunscreen composition of embodiment 41, wherein a lose, hydroxypropyl guar, hydroxypropyl methylcellu polyguarternium is polyguarternium-4, -7, -11, -22, -37. lose, isopropyl ester of PVM/MA copolymer, -44, -5, and -64. maltodextrin, melamine/formaldehyde resin, methacry 173. A Sunscreen composition of any one of embodiments loyl ethyl betainelmethacrylates copolymer, nitrocellu 1-92, wherein the additional agent is a cationic agent. lose, octylacrylamide/acrylates/butylaminoethylmeth 174. A sunscreen composition of embodiment 173, wherein acrylate copolymer, octylacrylamide/acrylates the cationic agent is comprises about 0.1 to about 20%, or copolymer, phthalic anhydride/glycerin/glycidyl decano about 0.1 to about 10%, or about 0.5 to about 10%, or 25 ate copolymer, phthalic/trimellitic/glycols copolymer, about 1 to about 10%, or about 0.5 to about 5%, or about polyacrylamide, polyacrylamidomethylpropane Sulfone 0.5 to about 3% or about 1 to about 5%, or about 1 to acid, polyacrylic acid, polybutylene terephthalate, poly about 3% of the sunscreen composition (w/v). chlorotrifluoroethylene, polyethylacrylate, polyethylene, 175. A sunscreen composition of embodiment 173, wherein polyethylene terephthalate, polyisobutene, Polyguarter the cationic agent comprises about 0.1%, 0.2%, 0.3%, 30 nium-1, Polyguarternium-2, Polyguarternium-4, Poly 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1% or 1%, 2%, 3%, quarternium-5, Polyguarternium-6, Polyguarternium-7. 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, Polyguarternium-8, Polyguarternium-9, Polyguarter 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, nium-10, Polyguarternium-11, Polyguarternium-12, Poly 25%, 26%, 27%, 28%, 29%, 30%, 35%, 40%, 45%, 50%, quarternium-13, Polyguarternium-14, Polyguarternium 55%, 60%. 65% or more of the sunscreen composition 35 15, polystyrene, polyvinyl acetate, polyvinyl alcohol, (w/v). polyvinylbutyral, polyvinyl imidazolinium acetate, poly 176. A Sunscreen composition of any of embodiments 1-2, vinyl laurate, polyvinyl methyl ether, potassium carra wherein the additional agent is a film barrier system. geenan, PVM/MA copolymer, PVP, PVP/dimethylamino 177. A sunscreen composition of embodiment 176, wherein ethymethacrylate copolymer, PVP/eicosene copolymer, the film barrier system is selected from petrolatum, silicon 40 PVP/ethyl methacrylate/methacrylic acid copolyerm, derivatives and polymers with carboxylic ends. PVP/hexadecene copolymer, PVP/VA copolymer, PVP/ 178. A sunscreen composition of embodiment 176, wherein vinyl acetate/itaconic acid copolymer, rosin, serum albu the film barrier system is encapsulated in a cellulose min, shellac, Sodium acrylate/vinyl alcohol, copolymer, derived capsule. Sodium carrageen, sodium polymethacrylate, Sodium 179. A sunscreen composition of embodiment 176, wherein 45 polystyrene Sulfonate, starch/acrylates/acrylamide copo the film barrier system is not encapsulated in a cellulose lymer, starch diethylaminoethyl ether, steaxyvinyl ether/ derived capsule. maleic anhydride copolymer, Styrenefacrylate/acryloni 180. A Sunscreen composition of any one of embodiments trile copolymer, styrenefacrylate/ammonium 1-92, wherein the additional agent is a film former. methacrylate copolymer, styrene/maleic anhydride copo 181. A sunscreen composition of embodiment 180, wherein 50 lymer, styrene/PVP copolymer, sucrose benzoate/Sucrose the film former is selected from emollient esters, lanolin acetate isobutyrate/butyl benzyl phthalate copolymer, derivatives, acetylated lanolins, dimethicone, Stearami sucrose benzoate/Sucrose acetate isobutyrate/butylbenzyl dopropyl dimethylamine Stearate tocopheryl acetate, phthalate/methyl methacrylate copolymer, Sucrose benzo Superfatted oils, synthetic wax, acacia gum, cellulose ate/Sucrose acetate isobutyrate copolymer, toluenesulfo derivatives, guar derivatives acrylamides copolymer, 55 namide/formaldehyde resin, tragacath gum, vinyl acetate/ acrylamide/sodium acrylate copolymer, acrylate/acrylam crotonates copolymer, vinyl acetate/crotonic acid ide copolymer, acrylate/ammonium methacrylate copoly copolymer, vinyl acetate/crotonic acid/methacryloxyben mer, acrylates copolymer, acrylates/diacetoneacrylamide Zophenon-1 copolymer, vinyl acetate/crotonic aid/vinyl copolymer, acrylic/acrylate copolymer, adipic acid/dim neodecanoate copolymer, Zein. ethylaminohydroxypropyl diethlenetnamine copolymer, 60 182. A sunscreen composition of embodiment 180, wherein adipic acid/epoxypropyl/diethlenetriamine copolymer, the film former is a liquid acrylic copolymer. albumen, allyl Stearate/VA copolymer, aminoethylacry 183. A sunscreen composition of embodiment 182, wherein late phosphate/acrylate copolymer, ammonium acrylates a Sunscreen composition includes a liquid acrylic copo copolymer, ammonium alginate, ammonium vinyl lymer at a concentration of about 0.05%, 0.1%, 0.2%, acetate/acrylates copolymer, AMP acrylates/diac 65 0.3%, 0.4%, or 0.5% or about 0.1%, 0.2%, 0.3%, 0.4%, etoneacrylamide copolymer, balsam canada, balsam 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1% or 1%, 2%, 3%, 4%, oregon, balsam peru, balsam tolu, benzol acid/phthalic 5%, 6%, 7%, 8%, 9%, 10% or more. US 9,456,967 B2 65 66 184. A sunscreen composition of embodiment 180, wherein 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, the film former is encapsulated in a cellulose derived 28%, 29%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65% capsule. or more (w/v). 185. A sunscreen composition of embodiment 180, wherein 199. A sunscreen composition of embodiment 196, wherein the film former is not encapsulated in a cellulose derived 5 the chelating agent is encapsulated in a cellulose derived capsule. capsule. 186. A Sunscreen composition of any one of embodiments 200. A sunscreen composition of embodiment 196, wherein 1-92, wherein the additional agent is a secondary film the chelating agent is not encapsulated in a cellulose former. derived capsule. 10 201. A Sunscreen composition of any one of embodiments 187. A sunscreen composition of embodiment 186, wherein 1-92, wherein the additional agent is a thickening agent or the secondary film former is selected from keratin or other gellant. protein derivative in an amino acid complex Such as 202. A sunscreen composition of embodiment 201, wherein cysteine. the thickening agent or gellant system is selected from 188. A sunscreen composition of embodiment 187, wherein 15 CARBOPOLTM resins e.g., 934,971,974, 980, 981 and a Sunscreen composition includes a secondary film former PEMULENTM ITR-1 and TR-2 both CARBOPOLTM at a concentration of about 0.1%, 0.2%, 0.3%, 0.4%, and PEMULENTM are registered trademarks of BF 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1% or 1%, 2%, 3%, 4%, Goodrich, Noveon AA-1, ETD resins, and ULTREZTM 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, resins registered trademark, BFGoodrich or carbomers. 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 203. A sunscreen composition of embodiment 201, wherein 26%. 27%, 28%, 29%, 30%, 35%, 40%, 45%, 50%, 55%, the thickening agent or gellant is encapsulated in a 60%, 65% or more. cellulose derived capsule. 189. A sunscreen composition of embodiment 186, wherein 204. A sunscreen composition of embodiment 201, wherein the secondary film former is encapsulated in a cellulose the thickening agent or gellant is not encapsulated in a derived capsule. 25 cellulose derived capsule. 190. A sunscreen composition of embodiment 186, wherein 205. A Sunscreen composition of any one of embodiments the secondary film former is not encapsulated in a cellu 1-92, wherein the additional agent is a fragrance, dye or lose derived capsule. antimicrobial material. 191. A Sunscreen composition of any one of embodiments 206. A sunscreen composition of embodiment 205, wherein 1-92, wherein the additional agent is a preservative. 30 the antimicrobial material is selected from triclocarban, 192. A sunscreen composition of embodiment 191, wherein triclosan, iodophors, iodine formulations, phenolic com the preservative is selected from citric acid, tartaric acid, pounds, e.g. hexachlorophene, and bisbiguanides, e.g. phosphoric acid, iminodiacetic acid, nitrilotriacetic acid, chlorhexidene gluconate. hydroxyethyleneaminodiacetic acid and ethylenedi 207. A sunscreen composition of embodiment 205, wherein 35 fragrance, dye or antimicrobial material is encapsulated in aminetetraacetic acid and salts thereof, para-hydroxyben a cellulose derived capsule. Zoates such as butyl paraben, methyl paraben and propyl 208. A sunscreen composition of embodiment 205, wherein paraben; imidazolines, imidiazolinylurea, triclosan, the fragrance, dye or antimicrobial material is not encap hydantoins, dimethyloldimethylhydantoin, isothiazolidi Sulated in a cellulose derived capsule. none compounds and mixtures thereof, methylchloroiso 40 209. A Sunscreen composition of any one of embodiments thiazolinone and methylisothiazolinone. 1-208, wherein the composition is mixed together in a 193. A sunscreen composition of embodiment 191, wherein water or an oil. the concentration of preservative in a Sunscreen compo 210. A Sunscreen composition of any one of embodiments sition is about 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 1-92, wherein the additional agent is a Surfactant. 0.7%, 0.8%, 0.9%, 1% or 1%, 2%, 3%, 4%, 5%, 6%, 7%, 45 211. A sunscreen composition of embodiment 210, wherein 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, the Surfactant is selected from cationic, anionic, nonionic, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, Zwitterionic, amphoteric, or any combination of Surfac 28%, 29%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65% tants thereof. In a further embodiment, surfactants or more (w/v). include, without limitation, alkyl and alkyl ether sulfates, 194. A sunscreen composition of embodiment 191, wherein 50 Sulfated monoglycerides, Sulfonated olefins, alkyl aryl the preservative is encapsulated in a cellulose derived Sulfonates, primary or secondary alkane Sulfonates, alkyl capsule. SulfoSuccinates, acyl taurates, acyl isethionates, alkyl 195. A sunscreen composition of embodiment 191, wherein glycerylether Sulfonate, Sulfonated methyl esters, Sul the preservative is not encapsulated in a cellulose derived fonated fatty acids, alkyl phosphates, ethoxylated alkyl capsule. 55 phosphates, acyl glutamates, acyl sarcosinates, alkyl Sul 196. A Sunscreen composition of any one of embodiments foacetates, acylated peptides, alkyl ether carboxylates, 1-92, wherein the additional agent is a chelating agent. acyl lactylates, anionic fluoroSurfactants, sodium, ammo 197. A sunscreen composition of embodiment 196, wherein nium, potassium, magnesium, or TEA salts of lauryl or the chelating agent is selected from heterocyclic ring myristyl Sulfate or ammonium, Sodium, magnesium, or structures, ethylene diaminetetraacetic acid (EDTA), 60 TEA laureth-3 sulfate and combinations thereof. EDTA disodium, calcium disodium edetate, EDTA triso 212. A sunscreen composition of embodiment 201, wherein dium, EDTA tetrasodium and EDTA dipotassium. the concentration of Surfactant included in a Sunscreen 198. A sunscreen composition of embodiment 196, wherein composition is at least 0.01%, at least 0.02%, at least the concentration of chelating agent in a Sunscreen com 0.03%, at least 0.04%, at least 0.05%, at least 0.06%, at position is about 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 65 least 0.07%, at least 0.08%, at least 0.09%, at least 0.1%, 0.7%, 0.8%, 0.9%, 1% or 1%, 2%, 3%, 4%, 5%, 6%, 7%, at least 0.25%, at least 0.5%, at least 0.75%, at least 1%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, at least 1.25%, at least 1.5%, at least 1.75%, at least 2%, US 9,456,967 B2 67 68 at least 2.25%, at least 2.5%, at least 2.75%, at least 3%, wherein R1 is a saturated or unsaturated, branched or at least 3.25%, at least 3.5%, at least 3.75%, at least 4%, unbranched alkyl group from about 8 to about 24 carbon at least 4.25%, at least 4.5%, at least 4.75%, at least 5%, atoms, and M is a water-soluble cation Such as ammo at least 5.25%, at least 5.5%, at least 5.75%, at least 6%, nium, Sodium, potassium, magnesium, triethanolamine, at least 6.25%, at least 6.5%, at least 6.75%, at least 7%, diethanolamine and monoethanolamine, Sodium coco at least 7.25%, at least 7.5%, at least 7.75%, at least 8%, glyceryl ether sulfonate, Sulfonated fatty acids of the at least 8.25%, at least 8.5%, at least 8.75%, at least 9%, form R1-CH(SO) COOH and sulfonated methyl esters at least 9.25%, at least 9.5%, at least 9.75%, at least 10%, of the from R1-CH(SO) CO-O CH, where R1 is a at least 11%, at least 12%, at least 13%, at least 14%, at saturated or unsaturated, branched or unbranched alkyl least 15%, at least 16%, at least 17%, at least 18%, at least 10 group from about 8 to about 24 carbon atoms, alpha 19%, at least 20%, at least 21%, at least 22%, at least Sulphonated coconut fatty acid and lauryl methyl ester; 23%, at least 24%, at least 25% (w/v). phosphates Such as monoalkyl, dialkyl, and trialkylphos 213. A sunscreen composition of embodiment 210, wherein phate salts formed by the reaction of phosphorous pen the concentration of Surfactant included in a Sunscreen toxide with monohydric branched or unbranched alcohols composition is about 0.01% to about 5%. 15 having from about 8 to about 24 carbon atoms, Sodium 214. A sunscreen composition of embodiment 210, wherein mono or dilaurylphosphate, ethoxylated monoalkyl phos the concentration of Surfactant included in a Sunscreen phates, acyl glutamates corresponding to the formula composition is about 3% to about 5%. R1CO N(COOH) CHCH COM wherein R1 is a 215. A sunscreen composition of embodiment 213, wherein saturated or unsaturated, branched or unbranched alkyl or the concentration of surfactant results in reduced lather alkenyl group of about 8 to about 24 carbon atoms, and M 1ng. is a water-soluble cation, Sodium lauroyl glutamate and 216. A sunscreen composition of embodiment 210, wherein Sodium cocoyl glutamate, alkanoyl sarcosinates corre the concentration of Surfactant included in a Sunscreen sponding to the formula R1CON(CH) CHCH composition is about 7.5% to 15%. COM wherein R1 is a saturated or unsaturated, branched 217. A sunscreen composition of embodiment 216, wherein 25 or unbranched alkyl or alkenyl group of about 10 to about the concentration of Surfactant results in lathering. 20 carbon atoms, and M is a water-soluble cation, Sodium 218. A sunscreen composition of embodiment 210, wherein lauroyl sarcosinate, lauroyl sarcosine, sodium cocoyl sar the Surfactant is an anionic Surfactant. cosinate, and ammonium lauroyl sarcosinate, alkyl ether 219. A sunscreen composition of embodiment 218, wherein carboxylates corresponding to the formula R1 the anionic Surfactant is selected from Sulfated monoglyc 30 (OCHCH)x-OCH COM wherein R1 is a saturated erides of the form R1CO-O CH, C(OH)H CH or unsaturated, branched or unbranched alkyl or alkenyl O SOM, wherein R1 is a saturated or unsaturated, group of about 8 to about 24 carbon atoms, X is 1 to 10, branched or unbranched alkyl group from about 8 to about and M is a water-soluble cation (e.g., Sodium laureth 24 carbon atoms, and M is a water-soluble cation Such as carboxylate); acyl lactylates corresponding to the formula ammonium, Sodium, potassium, magnesium, trietha 35 R1CO-O-CH(CH) COX-COM wherein R1 is a nolamine, diethanolamine, monoethanolamine and saturated or unsaturated, branched or unbranched alkyl or Sodium cocomonoglyceride Sulfate, olefin Sulfonates of alkenyl group of about 8 to about 24 carbon atoms, X is the form R1SOM, wherein R1 is a mono-olefin having 3, and M is a water-soluble cation, Sodium cocoyl lacty from about 12 to about 24 carbon atoms, and M is a late, carboxylates, nonlimiting examples of which include water-soluble cation such as ammonium, Sodium, potas 40 Sodium lauroyl carboxylate, Sodium cocoyl carboxylate, sium, magnesium, triethanolamine, diethanolamine and and ammonium lauroyl carboxylate; anionic flouroSurfac monoethanolamine, sodium C14/C16 alpha olefin sul tants; natural Soaps derived from the Saponification of fonate, linear alkylbenzene sulfonates of the form vegetable and/or animal fats & oils examples of which R—CH, SOM, wherein R1 is a Saturated or unsatu include Sodium laurate, sodium myristate, palmitate, rated, branched or unbranched alkyl group from about 8 45 Stearate and tallowate cocoate. to about 24 carbon atoms, and M is a water-soluble cation 220. A sunscreen composition of embodiment 210, wherein Such as ammonium, Sodium, potassium, magnesium, tri the Surfactant is a taurate. ethanolamine, diethanolamine monoethanolamine and 221. A sunscreen composition of embodiment 218, wherein Sodium dodecylbenzene Sulfonate. In an additional the taurate is selected from taurine, N-alkyltaurines. embodiment, anionic Surfactants include, without limita 50 222. A sunscreen composition of embodiment 210, wherein tion, primary or secondary alkane Sulfonates of the form the Surfactant is a nonionic Surfactant. R1 SOM, wherein R1 is a saturated or unsaturated, 223. A sunscreen composition of embodiment 218, wherein branched or unbranched alkyl chain from about 8 to about the nonionic Surfactant is selected from alkyl glucosides, 24 carbon atoms, and M is a water-soluble cation Such as alkyl polyglucosides, polyhydroxy fatty acid amides, ammonium, Sodium, potassium, magnesium, trietha 55 alkoxylated fatty acid esters, sucrose esters, amine oxides, nolamine, diethanolamine and monoethanolamine, alkane glycosides or polyglycosides and are represented by the sulfonate, alkali metal or ammonium C 13 C 17 paraffin formula (S), O—R wherein S is a Sugar moiety Such as Sulfonates, alkyl SulfoSuccinates, which include disodium glucose, fructose, mannose, and galactose; n is an integer N-octadecylsulfo Succinamate; diammonium lauryl Sulfo of from about 1 to about 1000, and R is a Cso alkyl group succinate; tetrasodium N-(1,2-dicarboxyethyl)-N-octade 60 decyl alcohol, cetyl alcohol, Stearyl alcohol, lauryl alco cylsulfo Succinate; diamyl ester of sodium SulfoSuccinic hol, myristyl alcohol, oleyl alcohol, decyl polyglucoside, acid; dihexyl ester of Sodium SulfoSuccinic acid; dioctyl Sucrose cocoate, polyhydroxy fatty acid amide, glucos esters of Sodium sulfoSuccinic acid, acyl isethionates, amides and Sucrose laurate. including, without limitation, acyl isethionates include 224. A sunscreen composition of embodiment 210, wherein ammonium cocoylisethionate, Sodium cocoylisethionate, 65 the Surfactant is an amphoteric lathering Surfactant. Sodium lauroylisethionate, alkylglyceryl ether Sulfonates 225. A sunscreen composition of embodiment 218, wherein of the form R1-OCH C(OH)H CH, SOM, the amphoteric lathering Surfactant is selected from car US 9,456,967 B2 69 70 boxy, Sulfonate, Sulfate, phosphate, or phosphonate. In an 12, 1.3, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, embodiment, amphoteric or Zwitterionic Surfactants 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, include, without limitation, betaines, Sultaines, hydroxy 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, Sultaines, alkyliminoacetates, iminodialkanoates, amino 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, alkanoates, coco dimethyl carboxymethyl betaine, lauryl 5 72, 73, 74, 75 or more. dimethyl carboxymethyl betaine, lauryl dimethyl alphac 234. A Sunscreen composition of any one of embodiments arboxyethyl betaine, cetyl dimethyl carboxymethyl 1-234, wherein the composition is applied two or more betaine, cetyl dimethyl betaine (available as Lonzaine times to an individual and the cumulative SPF protection 16SP from Lonza Corp.), lauryl bis-(2-hydroxyethyl) following the two or more applications is at least about at carboxymethyl betaine, oleyl dimethyl gamma-carboxy 10 propyl betaine, lauryl bis-(2-hydroxypropyl)alpha-car least about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 1.3, 14, 15, boxyethyl betaine, coco dimethyl sulfopropyl betaine, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, lauryl dimethyl sulfoethyl betaine, lauryl bis-(2-hydroxy 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, ethyl) sulfopropyl betaine, amidobetaines and amidosul 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, fobetaines (wherein the RCONHCCH) radical is 15 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75 attached to the nitrogen atom of the betaine), oleyl, and O. O. cocamidopropyl betaine, Sultaines, hydroxysultaines and 235. A Sunscreen composition of any one of embodiments cocamidopropyl hydroxysultaine. 1-234, wherein the composition is applied once per day. 226. A sunscreen composition of embodiment 210, wherein 236. A Sunscreen composition of any one of embodiments the Surfactant is an amphoteric Surfactant. 1-234, wherein the composition is applied two, three, four 227. A sunscreen composition of embodiment 218, wherein or more times per day. the amphoteric surfactant is selected from taurine, Cetyl 237. A Sunscreen composition of any one of embodiments dimethyl betaine, Cocamidopropylbetaine; Cocamidopro 1-234, wherein the composition is applied every other pyl hydroxy Sultaine, alkyliminoacetates, and iminodial day. kanoates and aminoalkanoates of the formulas RN(CH2) 25 238. A Sunscreen composition of any one of embodiments COM) and RNH(CH2)COM wherein m is from 1 to 1-234, wherein the composition is applied about 10, 8, 7. 4, R is a C-C alkyl or alkenyl, and M is H. alkali metal, 6, 5, 4, 3, 2 or 1 time per week. alkaline earth metal ammonium, alkanolammonium or 239. A Sunscreen composition of any one of embodiments imidazolinium and ammonium derivatives, sodium 3-do 1-238, wherein the composition is applied to wet skin decyl-aminopropionate, sodium 3-dodecylaminopropane 30 and/or hair. Sulfonate, N-higher alkyl aspartic acids, amphoteric phos 240. A Sunscreen composition of any one of embodiments phates, such as coamidopropyl PG-diimonium chloride 1-238, wherein the composition is applied to dry skin phosphate, disodium lauroamphodiacetate, Sodium lauro and/or hair. amphoacetate, and mixtures thereof. 241. A Sunscreen composition of any one of embodiments 228. A sunscreen composition of embodiment 210, wherein 35 1-240, wherein the composition contains one, two or more the Surfactant is a cationic Surfactant. surface-treated metal oxide pigments that block UV radia 229. A sunscreen composition of embodiment 218, wherein tion. the cationic Surfactant is selected from fatty amines, 242. A Sunscreen composition of embodiment 241, wherein di-fatty quaternary amines, tri-fatty quaternary amines, the surface-treated metal oxide blocks UV radiation in the imidazolinium quaternary amines, monoalkyl quaternary 40 wavelength range of from about 290 nm to about 400 nm. amines Such as cetyltrimethylammonium bromide, 243. A Sunscreen composition of embodiment 241, wherein dialklamidoethyl hydroxyethylmonium methosulfate the combined concentration of the one, two or three stearyldimenthylbenzyl ammonium chloride; dodecylt Surface-metal oxide pigments is at least about 0.1%, rimethylammonium chloride; nonylbenzylethyldimethyl 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, ammonium nitrate; tetradecylpyridinium bromide; lau 45 1.25%, 1.5%, 1.75%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, rylpyridinium chloride; cetylpyridinium chloride; lau 5%, 5.5%, 6%, 6.5%, 7%, 7.5%, 8%, 8.5%, 9%, 9.5%, rylpyridinium chloride; laurylisoquinolium bromide; 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, ditallow(Hydrogenated)dimethyl ammonium chloride; 20%, 25%, 30%, 35%, 40%, 45%, 50%. dilauryldimethyl ammonium chloride and Stearalkonium 244. A Sunscreen composition of any one of embodiments chloride. 50 1-243, wherein the cellulose derived capsules containing 230. A sunscreen composition of embodiment 210, wherein Sunscreen active agents are in the 400-450 nm range. the concentration of a cationic Surfactant included in a 245. A Sunscreen composition of any one of embodiments sunscreen composition is about 0.1%, 0.2%, 0.3%, 0.4%, 1-243, wherein the cellulose derived capsules containing 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1% or 1%, 2%, 3%, 4%, Sunscreen active agents are in the 400-500 nm range. 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 55 246. A Sunscreen composition of any one of embodiments 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 1-243, wherein the cellulose derived capsules containing 26%. 27%, 28%, 29%, 30%, 35%, 40%, 45%, 50%, 55%, Sunscreen active agents are in the 400-550 nm range. 60%. 65% or more (w/v). 247. A Sunscreen composition of any one of embodiments 231. A sunscreen composition of embodiment 210, wherein 1-243, wherein the cellulose derived capsules containing the Surfactant is encapsulated in a cellulose derived cap 60 Sunscreen active agents are in the 400-600 nm range. Sule. 248. A Sunscreen composition of any one of embodiments 232. A sunscreen composition of embodiment 210, wherein 1-243, wherein the cellulose derived capsules containing the Surfactant is not encapsulated in a cellulose derived Sunscreen active agents are in the 400-650 nm range. capsule. 249. A Sunscreen composition of any one of embodiments 233. A Sunscreen composition of any one of embodiments 65 1-248, wherein the cellulose derived capsules contain an 1-232, wherein the composition provides an SPF protec active coating on the exterior of the cellulose derived tion that is at least about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, capsule membrane which has absorption properties. US 9,456,967 B2 71 72 250. A Sunscreen composition of any one of embodiments 271. A Sunscreen composition of any one of embodiments 1-249, wherein the cellulose derived capsules, further 1-270, wherein the composition is comprised of a cellu wherein, the cellulose derived capsules are of different lose derived capsule comprising ethyl cellulose and a sizes. Surfactant base containing one or more polymers. 251. A Sunscreen composition of any one of embodiments 5 272. A Sunscreen composition of any one of embodiments 1-250, wherein the cellulose derived capsule is comprised 1-270, wherein the composition is comprised of a cellu of 0.1%-5% wt/wt of cellulosic material. lose derived capsule comprising carboxymethyl cellulose 252. A Sunscreen composition of any one of embodiments and a Surfactant base containing one or more polymers. 1-250, wherein the cellulose derived capsule is comprised 273. A Sunscreen composition of any one of embodiments of 5%-20% wit/wt of cellulosic material. 10 1-272, wherein the Sunscreen active agent is an organic or 253. A Sunscreen composition of any one of embodiments non-polar highly refractive Sunscreen active agent. 1-250, wherein the cellulose derived capsule is comprised 274. A Sunscreen composition of any one of embodiments of 20%-50% wit/wt of cellulosic material. 1-273, wherein the Sunscreen active agent is an organic 254. A Sunscreen composition of any one of embodiments 15 Sunscreen active agent and wherein, the composition 1-250, wherein the cellulose derived capsule is comprised contains inorganic metals. of 50%–70% wit/wt of cellulosic material. 275. A Sunscreen composition of any one of embodiments 255. A Sunscreen composition of any one of embodiments 1-274, wherein the Sunscreen composition comprises a 1-254, wherein the cellulose derived capsule is comprised Surfactant, a polymer and a cellulose derived capsule, of two or more layers. further wherein, the composition is comprised of one or 256. A sunscreen composition of embodiment 255, wherein more different cellulose derived capsules, each comprised each layer contains a different Sunscreen active agent. of a different cellulose derivative. 257. A sunscreen composition of embodiment 255, wherein 276. A Sunscreen composition of any one of embodiments each layer contains the same Sunscreen active agent. 1-275, wherein the inner refractive index of the compo 258. A sunscreen composition of embodiment 255, wherein 25 sition is 1.5-1.7. each layer contains a different Sunscreen active agent. 277. A Sunscreen composition of any one of embodiments 259. A sunscreen composition of embodiment 255, wherein 1-275, wherein the inner refractive index of the compo at least one layer contains a different Sunscreen active sition is 1.5-1.7. agent than at least one other layer. 278. A Sunscreen composition of any one of embodiments 260. A sunscreen composition of embodiment 255, wherein 30 1-275, wherein the inner refractive index of the compo at least one layer contains a Sunscreen active agent and at sition is 1.5-1.9. least one layer contains an antioxidant. 279. A sunscreen composition of any one of embodiments 261. A sunscreen composition of embodiment 255, wherein 1-275, wherein the inner refractive index of the compo at least one layer contains a Sunscreen active agent and at sition is 1.5-2.2. least one layer contains a vitamin. 35 280. A Sunscreen composition of any one of embodiments 262. A sunscreen composition of embodiment 255, wherein 1-275, wherein the inner refractive index of the compo at least one layer contains a Sunscreen active agent and at sition is 1.5-2.4. least one layer contains an anti-inflammatory. 281. A Sunscreen composition of any one of embodiments 263. A sunscreen composition of embodiment 255, wherein 1-275, wherein the inner refractive index of the compo at least one layer contains a Sunscreen active agent and at 40 sition is 1.5-2.6. least one layer contains an astringent. 282. A Sunscreen composition of any one of embodiments 264. A Sunscreen composition of any one of embodiments 1-275, wherein the inner refractive index of a non 1-263, wherein the composition is comprised of a cationic Sunscreen active agent in the composition is 1.5-2.7. Surfactant, a cellulose derived capsule and a polymer. 283. A Sunscreen composition of any one of embodiments 265. A Sunscreen composition of any one of embodiments 45 1-275, wherein the inner refractive index of a non organic 1-263, wherein the composition is comprised of an dispersed with organic Sunscreen active agent in the anionic Surfactant, cellulose derived encapsulate, and a composition is 1.5-2.7. polymer. 284. A Sunscreen composition of any one of embodiments 266. A Sunscreen composition of any one of embodiments 1-283, wherein the composition contains cellulose 1-263, wherein the composition is comprised of a non 50 derived capsules of different sizes and the inner refractive ionic Surfactant, cellulose derived encapsulate, and a index of the composition is greater than 1.5. polymer. 285. A Sunscreen composition of any one of embodiments 267. A Sunscreen composition of any one of embodiments 1-283, wherein the composition contains cellulose 1-263, wherein the composition is comprised of an derived capsules, further wherein, the mixture of cellulose amphoteric Surfactant, cellulose derived encapsulate, and 55 derived capsules contains capsules containing different a polymer. cellulose derivatives and the inner refractive index of the 268. A Sunscreen composition of any one of embodiments composition is greater than 1.5. 1-263, wherein the composition is comprised of a surfac 286. A Sunscreen composition of any one of embodiments tant containing a quat group, wherein said quat group is 1-285, wherein the composition has an overall refractive capable of absorbing UV radiation. 60 index of 1.4-2. 269. A Sunscreen composition of any one of embodiments 287. A Sunscreen composition of any one of embodiments 1-263, wherein the composition is comprised of a surfac 1-286, wherein the cellulose derived capsule wherein tant metal complex to enhance reflective properties. 75% or more of the cellulose derived capsules have a 270. A Sunscreen composition of any one of embodiments diameter of about 300 nm to about 600 nm. 1-263, wherein the composition is comprised of more 65 288. A Sunscreen composition of any one of embodiments than one surfactant, a cellulose derived capsule and a 1-92, wherein the additional agent is a skin whitening polymer. active. US 9,456,967 B2 73 74 289. A sunscreen composition of embodiment 288, wherein 313. A sunscreen composition of embodiment 311, wherein the skin whitening agent is a skin lightener and/or a skin the plastic is selected from thermoplastics and thermoset bleaching agent. ting plastics. 290. A sunscreen composition of embodiment 288, wherein 314. A sunscreen composition of embodiment 313, wherein the skin whitening agent is encapsulated in a cellulose 5 derived capsule. the thermoplastics and thermosetting plastic are selected 291. A sunscreen composition of embodiment 288, wherein from polyethylene, polyamides, polyethylene terephtha the skin whitening agent is not encapsulated in a cellulose late, polyesters, acrylonitrile butadiene styrene, polycar derived capsule. bonate, polyurethane, polypropylene, melamine formal 292. A Sunscreen composition of any one of embodiments 10 1-92, wherein the additional agent is a cascading antioxi dehyde, phenolics, polyetheretherketone, polyetherimide, dant agent. polylactic acid, polymethyl methacrylate, polytetrafluo 293. A sunscreen composition of embodiment 292, wherein roethylene, urea-formaldehyde, polystyrene, polyvinyl the cascading antioxidant agent is emblica or synovia. chloride and polytetrafluoroethylene. 294. A sunscreen composition of embodiment 292, wherein 15 the cascading antioxidant agent is encapsulated in a 315. A sunscreen composition of embodiment 311, wherein cellulose derived capsule. the plastic is biodegradable. 295. A sunscreen composition of embodiment 292, wherein the cascading antioxidant agent is not encapsulated in a 316. A sunscreen composition of embodiment 311, wherein cellulose derived capsule. the plastic is used in a consumer product. 296. A Sunscreen composition of any one of embodiments 317. A sunscreen composition of embodiment 316, wherein 1-92, wherein the additional agent is a quencher active. the consumer product is an automobile. 297. A sunscreen composition of embodiment 288, wherein 318. A sunscreen composition of embodiment 317, wherein the quencher is Polycrylene. the plastic in the automobile includes vinyl. 298. A sunscreen composition of embodiment 288, wherein 25 the quencher is encapsulated in a cellulose derived cap 319. A Sunscreen composition of any one of embodiments Sule. 1-318, wherein the Sunscreen composition is encapsulated 299. A sunscreen composition of embodiment 288, wherein in a cellulose derived capsule and further, wherein, the the quencher is not encapsulated in a cellulose derived encapsulated composition is used in a paint. capsule. 30 320. A Sunscreen composition of any one of embodiments 300. A sunscreen composition of any one of embodiments 1-319, wherein the composition is used in a military, 1-92, wherein the additional agent is an infrared reflective police or other governmental or non-governmental force coating. product. 301. A sunscreen composition of embodiment 288, wherein the infrared reflective coating is encapsulated in a cellu 35 321. A sunscreen composition of embodiment 320 wherein lose derived capsule. the military, police or other governmental or non-govern 302. A sunscreen composition of embodiment 288, wherein mental force product is selected from, Sunscreen, paint, the infrared reflective coating is not encapsulated in a clothes, weapons, including, without limitation, weapons cellulose derived capsule. containing composite or other synthetic parts, and other 303. A Sunscreen composition of any one of embodiments 40 military products. 2-302, wherein the soap includes a surfactant. 322. A sunscreen composition of embodiment 320 wherein 304. A Sunscreen composition of any one of embodiments the military, police or other governmental or non-govern 2-302, wherein the soap does not include a surfactant. mental force product includes a reflective agent. 305. A sunscreen composition of any one of embodiments 2-302, wherein the Soap is a melt and pour Soap. 45 323. A sunscreen composition of embodiment 320 wherein 306. A Sunscreen composition of any one of embodiments the military, police or other governmental or non-govern 2-302, wherein the soap is Castile soap. mental force product includes an agent capable of pre 307. A sunscreen composition of any of embodiments 1-92, venting the detection of infrared radiation by an indi wherein the additional agent is a hindered amine light vidual or equipment. stabilizer. 50 308. A sunscreen composition of embodiment 288, wherein EXAMPLES the hindered amine light stabilizer is encapsulated in a cellulose derived capsule. 309. A sunscreen composition of embodiment 288, wherein Example 1 the hindered amine light stabilizer is not encapsulated in 55 a cellulose derived capsule. 310. A Sunscreen composition of any one of embodiments SPF Testing of Sunscreen Composition 1-309, wherein the sunscreen composition is encapsulated in a cellulose derived capsule and, further wherein, the Various Sunscreen compositions were tested to determine composition is included in a paint. 60 their SPF value. The test consisted of applying the sunscreen 311. A Sunscreen composition of any one of embodiments composition by wetting the application site on an individual 1-309, wherein the sunscreen composition is encapsulated with 10 ml of water delivered via a syringe followed by in a cellulose derived capsule and, further wherein, the application of the test material monograph amount. The encapsulated composition is included in a plastic. lather was then worked in for two minutes. After 30 seconds, 312. A sunscreen composition of embodiment 311, wherein 65 the site was rinsed with 20 ml of water and patted dry. The the plastic is selected from natural, synthetic or semi test site was then rubbed using moderate pressure for 20 synthetic organic solids that are moldable. seconds. The material was allowed to dry for 15 minutes. US 9,456,967 B2 75 TABLE 1. Evaluation of Sun Protection by SPF Determination (FDA)-Static (Rinse/Lather/Rinse/Rub Subject Ia Skin MED I MED II SPF Values No. Gender MED/Hr (Amps) Type (JIM) (J/M) STD Static RLR/RUB 62-0539 F 127.3 6.O I 30.33 30.33 6.30 39.60 34.50 48-9212 F 1292 6.O II 46.2O 46.20 8.75 39.60 34.50 78-4159 M 127.1 6.O II 46.2O 46.20 6.30 34.50 30.00 78-4237 M 128.4 6.O II 46.2O 46.20 8.75 39.60 34.50 72-7479 M 128.1 6.O II 46.2O 46.20 8.75 34.50 30.00 76-O164 M 125.9 6.O II 46.2O 46.20 8.75 39.60 34.50 S4-1578 F 127.1 5.4 II 46.2O 46.20 6.30 39.60 34.50 58-3948 M 128.4 6.O II 46.2O 46.20 6.30 34.50 30.00 70-8402 F 126.9 5.9 III 46.2O 46.20 8.75 39.60 34.50 56-5529 F 125.4 6.O II 30.33 30.33 6.30 39.60 34.50 Mean (x) 7.53 38.07 33.15 Standard Deviation(s) 1.29 2.46 2.17 Standard Error O41 O.78 O.69 Standard Error % of Mean 2.34 2.05 2.08 N O 10 10 Upper 5% t Dist. 2.2622 1.8331 1.8331 A Values O. 9228 1.4260 1.2579 Label SPF 6 36 31 “I is Intensity of Light Source. 7% PadO/3% Oxyb.

25

TABLE 2 Evaluation of Sun Protection by SPF Determination (FDA)-80 Minute Water Immersion Subject Ia Skin MED I MED II WR SPF Values No. Gender MED/Hr (Amps) Type (J/M) (J/M) STD Control Static WR 78-4159 M 127.1 6.O II 46.2O 46.20 16.3O 15.OO 34.5O 34.50 72-7479 M 128.1 6.O II 46.2O 46.20 18.7S 18.OO 34.SO 34.50 Mean (x) 17.53 16.SO 34.SO 34.50 Standard Deviation(s) 1.73 2.12 O.OO O.OO Standard Error 1.23 1...SO O.OO O.OO Standard Error % of Mean 7.02 9.09 O.OO O.OO N 2 2 2 2 “I is Intensity of Light Source. 7% PadO/3% Oxyb.

TABLE 3

Evaluation of Sun Protection by SPF Determination (FDA)-Rinse/Lather/Rinse/Rub Water Resistant-80 Minute Water Immersion

Subject Ia Skin MED I MED II WR SPF Values

No. Gender MED/Hr (Amps) Type (J/M) (J/M) STD Control Static WR

78-4159 M 126.7 5.8 II 46.2O 46.20 16.30 18.OO 34.5O 34.50 48-1671 F 126.2 6.O II 30.33 30.33 18.7S 1 S.OO 34.SO 3O.OO Mean (x) 17.53 16.SO 34.SO 32.25 Standard Deviation(s) 1.73 2.12 O.OO 3.18 Standard Error 1.23 1...SO O.OO 2.25 Standard Error % of Mean 7.02 9.09 O.OO 6.98 N 2 2 2 2

I is Intensity of Light Source. 7% PadO/3% Oxyb. US 9,456,967 B2 77 78 TABLE 4 Evaluation of Sun Protection by SPF Determination (FDA)-Static (Rinse/Lather/Rinse/Rub Subject Ia Skin MED I MED II SPF Values No. Gender MED/Hr (Amps) Type (JIM) (J/M) STD Static RLR/RUB 62-0539 F 127.3 6.O I 30.33 30.33 6.30 34.50 34.50 48-9212 F 1292 6.O II 46.2O 46.20 18.75 34.50 34.50 78-4159 M 127.1 6.O II 46.2O 46.20 16.3O 34.50 30.00 78-4237 M 128.4 6.O II 46.2O 46.20 18.75 39.60 34.50 72-7479 M 128.1 6.O II 46.2O 46.20 18.75 34.50 34.50 76-O164 M 125.9 6.O II 46.2O 46.20 18.7S 39.50 34.50 S4-1578 F 127.1 5.4 II 46.2O 46.20 16.3O 34.50 34.50 58-3948 M 128.4 6.O II 46.2O 46.20 16.3O 34.50 30.00 70-8402 F 126.9 5.9 III 46.2O 46.20 18.75 39.60 34.50 56-5529 F 125.4 6.O II 30.33 30.33 6.30 39.60 34.50 Mean (x) 7.53 36.54 33.60 Standard Deviation(s) 1.29 2.63 1.90 Standard Error O41 O.83 O.60 Standard Error % of Mean 2.34 2.27 1.79 N O 10 10 Upper 5% t Dist. 2.2622 1.8331 1.8331 A Values O. 9228 1.5246 1.1014 Label SPF 6 35 32 “I is Intensity of Light Source. 7% PadO/3% Oxyb.

TABLE 5 Evaluation of Sun Protection by SPF Determination (FDA)-80 Minute Water Immersion Subject Ia Skin MED I MED II WR SPF Values No. Gender MED/Hr (Amps) Type (J/M) (J/M) STD Control Static WR 78-4159 M 127.1 6.O II 46.2O 46.2O 16.30 1S.OO 34.SO 3O.OO 72-7479 M 128.1 6.O II 46.2O 46.20 18.75 18.OO 34.SO 3O.OO Mean (x) 17.53 16...SO 34.SO 3O.OO Standard Deviation(s) 1.73 2.12 O.OO O.OO Standard Error 1.23 1...SO O.OO O.OO Standard Error % of Mean 7.02 9.09 OOO O.OO N 2 2 2 2 I is Intensity of Light Source. 7% PadO/3% Oxyb.

TABLE 6 Evaluation of Sun Protection by SPF Determination (FDA)-Rinse/Lather/Rinse/Rub Water Resistant-80 Minute Water Immersion

Subject Ia Skin MED I MED II WR SPF Values No. Gender MED/Hr (Amps) Type (JIM) (J/M) STD Control Static WR 78-4159 M 126.7 5.8 II 46.2O 46.20 16.30 18.OO 34.SO 3O.OO 48-1671 F 126.2 6.O II 30.33 30.33 18.75 1S.OO 34.SO 3O.OO Mean (x) 17.53 16...SO 34.SO 3O.OO Standard Deviation(s) 1.73 2.12 O.OO O.OO Standard Error 1.23 1...SO O.OO O.OO Standard Error % of Mean 7.02 9.09 OOO O.OO N 2 2 2 2 I is Intensity of Light Source. 7% PadO/3% Oxyb.

Table 1 through Table 3 show that following administra Subsequent washing and patting dry of the spot on the tion of a Sunscreen composition to a spot on an adult 60 individual with water, the mean residual SPF from the individual and the Subsequent washing and patting dry of the Sunscreen composition applied to the spot on the individual spot on the individual with water, the mean residual SPF was 36.54 (Table 4), 34.50 (Table 5) and 34.50 (Table 6). from the Sunscreen composition applied to the spot on the Certain embodiments of the present invention are individual was 38.07 (Table 1), 34.50 (Table 2) and 34.50 described herein, including the best mode known to the (Table 3). 65 inventors for carrying out the invention. Of course, varia Table 4 through Table 6 show that following administra tions on these described embodiments will become apparent tion of a Sunscreen composition to a spot on a child and the to those of ordinary skill in the art upon reading the US 9,456,967 B2 79 80 foregoing description. The inventor expects skilled artisans filed or added per amendment, the transition term “consist to employ such variations as appropriate, and the inventors ing of excludes any element, step, or ingredient not speci intend for the present invention to be practiced otherwise fied in the claims. The transition term "consisting essentially than specifically described herein. Accordingly, this inven of limits the scope of a claim to the specified materials or tion includes all modifications and equivalents of the Subject steps and those that do not materially affect the basic and matter recited in the claims appended hereto as permitted by novel characteristic(s). Embodiments of the present inven applicable law. Moreover, any combination of the above tion so claimed are inherently or expressly described and described embodiments in all possible variations thereof is enabled herein. encompassed by the invention unless otherwise indicated All patents, patent publications, and other publications herein or otherwise clearly contradicted by context. 10 referenced and identified in the present specification are Groupings of alternative embodiments, elements, or steps individually and expressly incorporated herein by reference of the present invention are not to be construed as limita in their entirety for the purpose of describing and disclosing, tions. Each group member may be referred to and claimed for example, the compositions and methodologies described individually or in any combination with other group mem in Such publications that might be used in connection with bers disclosed herein. It is anticipated that one or more 15 the present invention. These publications are provided solely members of a group may be included in, or deleted from, a for their disclosure prior to the filing date of the present group for reasons of convenience and/or patentability. When application. Nothing in this regard should be construed as an any such inclusion or deletion occurs, the specification is admission that the inventors are not entitled to antedate Such deemed to contain the group as modified thus fulfilling the disclosure by virtue of prior invention or for any other written description of all Markush groups used in the reason. All statements as to the date or representation as to appended claims. the contents of these documents is based on the information Unless otherwise indicated, all numbers expressing a available to the applicants and does not constitute any characteristic, item, quantity, parameter, property, term, and admission as to the correctness of the dates or contents of So forth used in the present specification and claims are to be these documents. understood as being modified in all instances by the term 25 “about.” As used herein, the term “about” means that the The invention claimed is: characteristic, item, quantity, parameter, property, or term so 1. An oil-in-water emulsion composition comprising a qualified encompasses a range of plus or minus ten percent Sunscreen composition, the Sunscreen composition compris above and below the value of the stated characteristic, item, 1ng: quantity, parameter, property, or term. Accordingly, unless 30 a. flexible cellulose derived capsules comprising octoc indicated to the contrary, the numerical parameters set forth rylene and avobenzone; in the specification and attached claims are approximations b. flexible cellulose derived capsules comprising octinox that may vary. At the very least, and not as an attempt to limit ate, the application of the doctrine of equivalents to the scope of c. cellulose derived capsules comprising a silicone; the claims, each numerical indication should at least be 35 d. cellulose derived capsules comprising a fat including a construed in light of the number of reported significant digits triglyceride; and by applying ordinary rounding techniques. Notwith e. about 0.05% (w/v) to about 5% (w/v) of an antioxidant; standing that the numerical ranges and values setting forth and the broad scope of the invention are approximations, the f. about 0.1% to about 5% of a film former; numerical ranges and values set forth in the specific 40 wherein the flexible cellulose derived capsules consists examples are reported as precisely as possible. Any numeri essentially of hydroxypropylcellulose, hydroxypropyl cal range or value, however, inherently contains certain methylcellulose, ethylcellulose, carboxymethylcellu errors necessarily resulting from the standard deviation lose or any derivative of hydroxypropylcellulose, found in their respective testing measurements. Recitation of hydroxypropylmethylcellulose, ethylcellulose or car numerical ranges of values herein is merely intended to 45 boxymethylcellulose; serve as a shorthand method of referring individually to each wherein the flexible cellulose derived capsules and the separate numerical value falling within the range. Unless cellulose derived capsules have a mean diameter of otherwise indicated herein, each individual value of a about 300 nm to about 700 nm, and numerical range is incorporated into the present specifica wherein the composition has an SPF of at least about 20. tion as if it were individually recited herein. 50 2. The oil-in-water emulsion composition of claim 1, The terms “a,” “an,” “the' and similar referents used in wherein the amount of octinoxate is from about 1% (w/v) to the context of describing the present invention (especially in about 25% (w/v) of the total weight of the composition. the context of the following claims) are to be construed to 3. The oil-in-water emulsion composition of claim 2, cover both the singular and the plural, unless otherwise wherein the amount of octinoxate is from about 2% (w/v) to indicated herein or clearly contradicted by context. All 55 about 20% (w/v). methods described herein can be performed in any suitable 4. The oil-in-water emulsion composition of claim 3, order unless otherwise indicated herein or otherwise clearly wherein the amount of octinoxate is from about 2% (w/v) to contradicted by context. The use of any and all examples, or about 10% (w/v). exemplary language (e.g., “such as') provided herein is 5. The oil-in-water emulsion composition of claim 3, intended merely to better illuminate the present invention 60 wherein the amount of octinoxate is from about 4.5% (w/v) and does not pose a limitation on the scope of the invention to about 15% (w/v). otherwise claimed. No language in the present specification 6. The oil-in-water emulsion composition of claim 1, should be construed as indicating any non-claimed element wherein the amount of octinoxate is at least 5% (w/v). essential to the practice of the invention. 7. The oil-in-water emulsion composition of claim 1, Specific embodiments disclosed herein may be further 65 wherein the amount of octocrylene is from about 0.5% (w/v) limited in the claims using consisting of or consisting to about 15% (w/v) and the amount of avobenzone is from essentially of language. When used in the claims, whether as about 2% (w/v) to about 4% (w/v). US 9,456,967 B2 81 82 8. The oil-in-water emulsion composition of claim 7. wherein the amount octocrylene is about 10% (w/v) or less and the amount of avobenzone is about 3% (w/v) or less. 9. The oil-in-water emulsion composition of claim 1, wherein the amount of the silicone is from about 2% (w/v) to about 15% (w/v). 10. The oil-in-water emulsion composition of claim 1, wherein the amount of the silicone is about 0.1% (w/v). 11. The oil-in-water emulsion composition of claim 1, wherein the amount of the silicone is about 1% (w/v). 10 12. oil-in-water emulsion composition of claim 1, wherein the silicone is dimethyl polysiloxane. 13. The oil-in-water emulsion composition of claim 1, wherein the amount of the fat is about 0.1% (w/v). 14. The oil-in-water emulsion composition of claim 1, 15 wherein the amount of the fat is about 0.2% (w/v). 15. The oil-in-water emulsion composition of claim 1, wherein the amount of the fat is about 0.3% (w/v). 16. The oil-in-water emulsion composition of claim 1, wherein the antioxidant is in an amount of about 0.05% (w/v) to about 2% (w/v). 17. The oil-in-water emulsion composition of claim 1, wherein the antioxidant is Vitamin E. 18. The oil-in-water emulsion composition of claim 1, wherein the flexible cellulose derived capsules and the 25 cellulose derived capsules have a mean diameter of about 400 nm to about 600 nm. 19. The oil-in-water emulsion composition of claim 1, wherein the film former is in an amount of about 0.2% (w/v) to about 3% (w/v). 30 20. The oil-in-water emulsion composition of claim 1, wherein the film former is liquid acrylic copolymer. k k k k k