Anti-EXOC7 monoclonal antibody, clone 80Y24G4 (CABT-B071) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Specificity This antibody recognizes complex exo70 subunit. Reactive against Mouse and Rat.

Target EXOC7

Immunogen Recombinant corresponding to full-length rat brain exo70 subunit

Isotype IgG

Source/Host Mouse

Species Reactivity Mouse, Rat

Clone 80Y24G4

Purification Protein G affinity purified

Conjugate Unconjugated

Applications WB, ELISA, IF

Format Liquid

Concentration 1mg/ml

Size 100μg

Preservative None

Storage Store at 4°C

Ship Shipped cold packs

BACKGROUND

Introduction Exocyst complex (also known as the sec6/8 complex) is a multimeric complex that has been implicated to play a role in exocytosis. This complex is conserved from yeast to mammals and is composed of eight subunits (Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70, and Exo84). In the budding yeast , mutations in these complex subunits promote

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Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved cytoplasmic accumulation of secretory vesicles and affects polarized growth. In cultured Drosophila and mammlian cells, disruption of exocyst subunit function has been found to decrease neurite outgrowth and Golgi-to-plasma membrane vesicle trafficking. Furthermore, a delay in neuronal induction was observed in mouse embryos with deletion of the sec8 , suggesting that the exocyst complex may play a role in cell differentiation and polarized growth.

Keywords EXOC7;exocyst complex component 7;EX070;EXO70;EXOC1;2-5-3p;Exo70p;YJL085W;exocyst complex component Exo70

GENE INFORMATION

Entrez Gene ID 23265

UniProt ID Q63HP7

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved