annual report 2005-2006

Celebratinga new name, same Milestones tradition of excellence.

university of wisconsin paul p. carbone comprehensive cancer center

message from the director

Celebratingresearch. education. treatment. hope. Dear Friends,

This past year, we celebrated a momentous milestone in the history of the Cancer Center.

We officially became the University of Wisconsin Paul P. Carbone Comprehensive Cancer Center. Additionally, the Cancer Center’s central research tower was named the Harold P. Rusch Translational Research Tower.

With unparalleled leadership, Paul P. Carbone and Harold P. Rusch made cancer research and patient care at the University of Wisconsin their lifework. Collectively, they established a hard-earned, worldwide reputation for innovative cancer research and treatment at the University of Wisconsin. The work of the two

men set a foundation for the Cancer Center’s evolution into the 21st century— welcome integrating basic science and clinical research more quickly into new patient care options.

In the pages that follow, you will read more about both Dr. Carbone and Dr. Rusch and the legacies they have left.

Decades of work by distinguished Cancer Center faculty have laid the groundwork for improvements in health care for the people of Wisconsin and beyond. At the Cancer Center, the science of medicine and art of compassion are carefully balanced. By creatively blending the unique expertise and resources of many  across the UW-Madison campus, the Cancer Center achieves a rich synergy of research, patient care, community service and education.

In this report, you’ll meet some of our researchers, physicians and staff—people whose work continues to create milestones within the Cancer Center’s history.

On behalf of our faculty and the individuals and families who benefit from their work, I thank you for your support of the University of Wisconsin Paul P. Carbone Comprehensive Cancer Center.

Sincerely,

George Wilding, MD Director UW Paul P. Carbone Comprehensive Cancer Center Anderson Professor of Medicine

 “Something Attempted, Something Done”

Celebratingharold P. Rusch, MD (1908-1988) time,” says UW Paul P. Carbone why certain treatments worked. In Comprehensive Cancer Center 1934, a former professor invited director, George Wilding, MD. “His him to teach physiology and was a remarkable achievement; establish a research laboratory. he developed not one cancer The offer forever shifted Rusch’s center, but two. People talk career away from practicing about translational research now, medicine and toward medical but Rusch was working toward discovery. creating complementary research and clinical programs back in the Also in 1934, the medical school 1930s.” received a bequest of nearly half a million dollars to support “We didn’t realize he was “fundamental studies regarding

. “Something Attempted, important,” remembers his the nature and cure of cancer.” Something Done” daughter, Carolyn Rusch The gift, coupled a year later by Schlotthauer, of Florida, “he was one from the estate of Michael harold P Throughout his long and R usch, MD productive life, Harold P. Rusch just ‘Daddy.’ He was a kind, McArdle, launched the school’s (’31 BA ’33 MD) seems to have nurturing father and grandfather to cancer program, and Harold quietly and effectively embraced Kristina and William. We were all Rusch’s life work. so very lucky to have him.” that sentiment. He chose it as the “Harold Rusch was a humble yet title of his autobiography and as a Rusch was a Wisconsin native forthright man who was not afraid philosophy of life. who grew up in Merrill, about to speak his mind,” says UW The man, who seven decades 20 miles north of Wausau. In professor emeritus Henry Pitot, ago began a career dedicated to his memoirs, he credits his MD, PhD, who succeeded Rusch understanding and conquering interest in medicine to a boyhood as McArdle director. “His goal cancer, left an indelible mark appendectomy that launched a was to significantly advance our on medical science at the short career as surgeon to his knowledge and control of cancer University of Wisconsin and the mother’s vegetables. That early in human patients. To realize his nation. A basic scientist first, experience, and the influence of goal Rusch brought together in a his contributions to the study his uncle, a Milwaukee physician, single interactive laboratory some and treatment of cancer were led him to college and medical of the brightest young minds in balanced by an equal genius in school at the University of cancer research. Wisconsin-Madison. building and administering the “While he always discussed with first research center in the nation “He was a wonderful, gentle, and urged his colleagues to dedicated to studying the causes knowledgeable person,” says his develop their studies as applied to and potential cures for cancer. second wife and widow, Louise human cancer, it wasn’t until the Ultimately, he established two Van Wart Rusch, “and an excellent UW Clinical Cancer Center (later world-class cancer centers on the judge of people.” known as the UW Comprehensive UW-Madison campus. Cancer Center) was established While still a medical student, “Harold Rusch was a visionary, that he came closer to his life’s Rusch demonstrated an innate dream.” a man decades ahead of his interest in knowing more about

 At age 30 and only four years out of medical school, Rusch worked with the state architect to design the first McArdle Laboratory, a wing of the Medical Sciences Center, and, 25 years later, he helped design the existing McArdle Laboratory.

“McArdle was his biggest pride and joy,” says his step-daughter, Virginia Francis of Middleton, Wisconsin. “He was a natural teacher—he always found a way to enrich any experience—always wanted to share his knowledge, but he lived and breathed his work.”

Rusch became the inaugural director of the McArdle Laboratory for Cancer Research in 1940. It was the first basic science cancer center in an academic institution in the United States and from the beginning it was committed Harold Rusch continued his cancer research while directing to understanding the causes of Wisconsin’s two leading cancer centers. hope cancer and to training exceptional basic science researchers. William F. Dove, PhD, one of six known as the UW Comprehensive Rusch was a dedicated scientist. Rusch faculty hires who later Cancer Center (UWCCC). The In 1941 he identified the became members of the National move from basic science research wavelength of ultraviolet light that Academy of Sciences, Rusch to the treatment side of the cancer produces skin cancer. Subsequent “combined a gentle demeanor fight was simply a continuation studies demonstrated a link with decisive action. This first of the same overarching vision. between obesity and cancer, enabled him to build a rapport A year later, the National Cancer and his belief that cancer was as a mentor of many young Institute recognized the UWCCC caused by a series of biochemical investigators, each driven by a as one of the nation’s first changes became the basis for creative ego. The second allowed university-based comprehensive studies on the stages of tumor him to connect with national cancer centers. formation. leaders, such as Congressman Melvin Laird, to crystallize Rusch hired his successor at the Rusch is also credited with legislation that promoted cancer UWCCC, Paul P. Carbone, MD creating an exceptional intellectual research funding.” in 1976, and in 1979 retired from environment at UW, one which UW-Madison. He continued to be encouraged talented researchers Throughout his life Rusch served active in professional activities, and facilitated interactions that on panels and commissions frequently coming into his office sparked new ways of studying designed to set national and when he and Louise weren’t a problem. It was Rusch who international cancer policy. He traveling throughout the world recognized the potential of young received numerous professional visiting family and colleagues. McArdle researchers such as awards and was active in many Nobel Prize-winner Howard Temin, cancer-related organizations, In 1988 Harold Rusch succumbed PhD, whose enzyme research including the American Cancer to the disease that he spent a helped to explain how retroviruses Society. lifetime trying to understand and cause cancer. conquer. In 1972 Rusch founded and According to UW professor of became the first director of UW oncology and medical genetics Clinical Cancer Center, later

 A founding father of cancer research and treatment

CelebratingPaul P. Carbone, MD (1931-2002) In his memoir, Rusch praised “He was very passionate about Carbone’s “excellent credentials his work and making lives better,” and wide experience in both according to his daughter, general medicine and cancer physician Kathryn Carbone, MD chemotherapy,” and his “deep ’83. “He talked constantly about concern for the problems and the quality of life and the need for welfare of patients.” Rusch’s people to fight cancer—even at a thought was to establish an time when it was common to send exemplary clinical program those with a diagnosis of cancer to complement the already home to die.” Not surprisingly, as recognized basic oncology chairman of the Breast Cancer research program at the McArdle Task Force, he created a vision

“Paul Carbone is recognized Lab, and Carbone was the for research policy of adjuvant . as a genius in his field. He man he wanted to lead clinical chemotherapy for people with was truly a founding father of oncology research at the UW. early-stage breast cancer. aul P

P cancer research and treatment.

carbone, MD At Wisconsin he laid a solid Says George Wilding, MD, director His colleagues recognized foundation upon which we of the UW Paul P. Carbone Carbone’s dedication and medical continue to build today.” Comprehensive Cancer Center, acumen. He received countless –George Wilding, MD “Paul Carbone is recognized as a national and international awards genius in his field. He was truly a throughout his lifetime, including When Paul Carbone arrived at the founding father of cancer research the prestigious Lasker Award for University of Wisconsin-Madison and treatment. At Wisconsin he Medicine, generally considered in 1976, he was already a well- laid a solid foundation upon which America’s Nobel Prize, for respected and award-winning we continue to build today.” combination chemotherapy cancer researcher and physician. for Hodgkin’s Lymphoma, He came to the UW Clinical A New York native, Carbone came demonstrating that cancer often Cancer Center—which under to the UW after retiring from the can be a successfully treated Paul P. Carbone, MD (1931-2002) his leadership developed into Commissioned Corps as Chief disease. the internationally renowned UW of the Medical Branch at the Comprehensive Cancer Center— National Cancer Institute (NCI), the He was a founding member during a period of transition. The culmination of an 18-year career and president of the American UWCCC had been created just in the Public Health Service. While Society of Clinical Oncology three years earlier by Harold P. at the NCI, Carbone started his and president of the American Rusch, MD, founder of UW’s 20-year service as chair of the Association for Cancer Research. McArdle Laboratory for Cancer Eastern Cooperative Oncology As the editor-in-chief of major Research, and Rusch was looking Group (ECOG), leading that oncology journals and author of for a successor. organization to become one of the nearly 400 publications, Carbone nation’s most respected clinical was influential in setting research In Carbone, Rusch found an research groups, with studies policy, both in the U.S. and enthusiastic, talented leader with conducted in more than 300 abroad. vision, dedication to research hospitals and medical schools. and profound respect and concern for people with cancer.

 In 1994, Steven T. Rosen, MD, then editor of Contemporary Oncology, described Carbone as “... a giant in our field, a pioneer in clinical investigation and a role model to scores of academicians involved in cancer research.”

Carbone’s scientific legacy is enormous. A member of the first certifying committee for the American Board of Internal Medicine for Medical Oncology, he helped write the first exam to set the standards for medical oncologists in the United States. He was also the inspiration and mentor for hundreds of cancer specialists who today continue to advance cancer discovery and care, including oncology treatment centers and training programs in Uganda, Taiwan and Singapore. Carbone was responsible for instituting medical oncology rotations through hospice care Paul Carbone was a beloved clinician, fondly remembered by both programs, and was a devoted his patients and colleagues. hope supporter of the Don and Marilyn Anderson Hospice Center in When son Matthew Carbone passionate, intelligent, sensitive Fitchburg, Wisconsin. Even after recalls his father, he says “He did and visionary man. what he did because he loved to he officially retired in 1997, “He did what he did because do it, not for the recognition or Carbone averaged 35 hours a he loved to do it, not for the week back in the UW Hospital money. As I grew up I was, and recognition or money. As I grew and Clinics’ “K tower,” continuing continue to be, so proud to meet up I was, and continue to be, drug research, guiding young his patients and students and so proud to meet his patients researchers and caring for learn of his achievements.” and students and learn of his achievements.” patients. “He is always in my head. I feel his –Matthew Carbone Outside of his cancer world, positive advice with me every time When he died unexpectedly in Carbone rode his bicycle, sailed, I make a significant decision.” 2002, Carbone was still deeply had a garden and liked to travel. Matt describes Carbone’s lasting involved in the subject that shaped But, says daughter Kathy, golf was legacies as his students and his his life—he was in the Far East, his passion. “He loved his golf, children. “Professionally, he was helping develop a comprehensive even confessing one day that the a great teacher who left behind cancer program at the National real reason he was late to dinner wonderful legacies at the UW University of Singapore...and was that he stopped for 9 holes of but also in Taiwan, Singapore, playing golf. golf after returning from a trip!” Africa and China. Personally, he Carbone and his wife Mary was perhaps most proud of the had seven children—three are accomplishments of his children.” physicians, one is an attorney and Kathy’s wish for her father is that three hold MBAs—and his lasting memory for both his 16 grandchildren. family and the world, be that he was an honorable, dedicated,

 Founders’Day Celebration Honoring the legacies of Dr. Harold P. Rusch and Dr. Paul P. Carbone Tuesday, September 26, 2006 Overture Center for the Arts, Madison

On September 26, 2006 the Cancer Center celebrated its world-renowned role in cancer research and treatment by honoring two revered leaders. The Cancer Center was named the UW Paul P. Carbone Comprehensive Cancer Center and the center’s central research tower as the Harold Rusch Translational Research Tower. More than 600 individuals gathered for the Founders’ Day Celebration at the Overture Center for the Arts in Madison to recognize both Dr. Paul P. Carbone and Dr. Harold Rusch.

ay event D ay F ounders’

Top right photo:The Honorable Jim Doyle, Governor of Wisconsin, and his wife Jessica participated in the program honoring Carbone and Rusch. They are joined by Cancer Center Director George Wilding, MD (center), his wife Helen and daughter Amanda. Bottom right photo: Jon McGlocklin, President of Midwest Athletes Against Childhood Cancer presents Dr. Wilding with a $3.5 million gift in support of childhood cancer research.

The University of Wisconsin Paul Event Sponsors P. Carbone Comprehensive Cancer Sponsor Partner Center gratefully acknowledges the Paul P. Carbone, MD Memorial Robert W. Baird & Co. Incorporated following supporters of the Founders’ Foundation Day Celebration: UW Health Department of Human Oncology, (UW Hospital and Clinics and UW School of Medicine and UW Medical Foundation) Public Health Department of Radiology, Premier Department of Surgery, UW School of Medicine and Midwest Athletes Against Childhood UW School of Medicine and Public Health Cancer Public Health Department of Medicine, UW School of Medicine and Public Health  Celebrating the legacy of Dr. Harold Rusch were several family members, including (left to right): Marge Senn, Roger Senn, Lynn Rusch, Don Van Wart, Gino Iavarone, Will Schlotthauer, Christina Schlotthauer, Kris Iavarone, Adam Schulz, Carolyn Schlotthauer, Virginia Francis, Louise Rusch, Lise Pollock, George Schlotthauer, George Francis, Elliot Schulz and Elise Freed-Brown.

The family of Dr. Paul P. Carbone celebrated the renaming of UW Comprehensive Cancer Center in his honor. They are, clockwise starting from upper left, David Carbone, Marybeth Catanzaro, Kathryn Carbone, Matthew Carbone, Paul Carbone, Mary Carbone, Kimberly Carbone and Bobbi Traber. H ope

Dr. Wilding welcomes Tommi Thompson (left), Dominick Carbone, Donna Sollenberger, President and CEO of UW Hospital and Clinics was in brother of the late Dr. Paul P. Carbone, and Sue Ann and Tommy attendance with David Entwistle, Chief Operating Officer of UW Hospital Thompson to the Founders’ Day Celebration. and Clinics (left) and Jeffrey Grossman, MD, President and Chief Executive Officer of the University of Wisconsin Medical Foundation.

Supporter Supporter Associate Friend M&I Bank Department of Anesthesiology, American Association of Cancer Boardman Law Firm LLP UW School of Medicine and Research (AACR) RBC Michael Best & Friedrich, LLP Public Health American Society of Clinical Reiman Foundation, Inc. Stark Investments Department of Dermatology, Oncology (ASCO) Winston & Strawn, LLP Venture Investors, LLC UW School of Medicine and Foley & Lardner, LLP Hematology/Oncology Section, Public Health Department of Ophthalmology, Department of Medicine, UW School Department of Obstetrics and UW School of Medicine and of Medicine and Public Health Gynecology, UW School of Medicine Public Health and Public Health  F. Michael Hoffmann, PhD, is the faculty advisor for the Cancer Center’s Small Molecule Screening Facility.

MilestoneSmall Molecule Screening Facility F. Michael Hoffmann, PhD is Also, if we can demonstrate that them are effective against cancer the faculty advisor for the Small a small molecule can affect a cells. So, we set up over a dozen Molecule Screening Facility. particular protein, it may open the cancer cell lines—breast and The facility was established door to developing a drug that prostate and ovarian and lung, for with funding from the UW Keck Center for Chemical Genomics could work on that target protein. example. We can screen a couple and the UW Paul P. Carbone of hundred novel compounds, Comprehensive Cancer Center Why was it important to indicating to the chemist if one (UWCCC). establish the Keck–UWCCC is more potent or one has some Small Molecule Screening specificity for a cancer type. That Facility at the UW? How has your career path led to helps them decide whether or not Small molecule screening is your current work? to do more work with a specific a basic research tool with I first studied chemistry, then compound. biochemistry, then genetics. very broad application. It’s been going on for a long time I came to McArdle in 1984 What is the Lead Discovery and did genetics research on in industry, but it’s only fairly Initiative? fruit flies until about six years recently that the thousands of In September, the Wisconsin research ago. Now, as faculty advisor at chemical compounds and the Alumni Research Foundation the Small Molecule Screening technology—such as liquid- (WARF) announced the Lead Facility (SMSF), I’m combining all handling robots—have become Discovery Initiative, which can those interests—small molecule accessible to academic centers. provide funding for assays on screening is sometimes called When the facility opened in 2003, new compounds for chemists, “chemical genetics.” it was probably one of only six in or for screening our collections the country. of compounds for biologists. A What are small molecules? committee reviews proposals from A small molecule is a chemical; How does screening work? around campus on a monthly it can be either a synthetic or a We have a library of more than basis, and supports both types of natural product. It is small only in 60,000 chemical compounds, research. comparison with larger biological in all different shapes, sizes and molecules, such as proteins, colors. And for any particular Does the SMSF run assays which tend to be hundreds of assay, or trial, we add them one at related to diseases besides times bigger. a time and ask, does this have an cancer? effect? It’s kind of the old needle Yes. As with any of the UWCCC Why are they important to in the haystack; we’re looking for core facilities, the SMSF is cancer research? one compound in 60,000 that has open to anyone on campus; it Small molecules are important an effect on an individual protein is a terrific contribution that the because some of them have the or distinct cell line. Cancer Center makes to the ability to interact with, or bind entire research effort on campus. with, a biological molecule and In addition to our chemical library, We are starting to do more work change its activity, to either inhibit there’s a lot of great chemistry on with viruses, and with infectious it or activate it. They become campus. UW chemists bring us disease and heart disease targets. tools for learning more about the novel compounds they’ve created function of that molecule. and ask us to determine if any of

 H offmann, michael F PHD .



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10 Kathy Schell is the supervisor of the UW Paul P. Carbone Comprehensive Cancer Center’s Flow Cytometry Facility.

MilestoneFlow Cytometry Facility In 1988 the UWCCC established What sets the UWCCC Flow What would people be the Flow Cytometry Facility to Cytometry Facility apart from surprised to learn about your serve the many research needs similar facilities in the country? years at the Cancer Center? of its members. As the demand Through the Cancer Center’s I got this job by accident. for its services has increased, support, we are able to maintain both within the Cancer Center state-of-the-art instrumentation What are the challenges and on campus, the facility has and have been successful in for people involved in your expanded offerings to cover obtaining National Institutes research? many cancer and non-cancer The biggest challenge will be areas of biological research. of Health funding for major securing funding to maintain For more than 18 years, Kathy instrument purchases. We are Schell has worked in the Flow educating our staff by sending the cutting edge technology we Cytometry Facility. them to national and international currently enjoy. There’s been a recent explosion in technology

classes and meetings. As a research What is flow cytometry? development, and a cytometer result, the facility has a broad N ame Flow cytometry measures spectrum of equipment and the purchased for $500,000 five years multiple molecules in or on single knowledgeable staff to support ago will be out-of-date in the cells at a very rapid rate in a any requirements our research next five years without significant liquid environment. A basic flow community might have. We are upgrades or replacements. cytometer contains a laser on among a handful of core facilities Where do you see flow one side of a flow cell and a with this breadth of technology cytometry in the future? light scatter detector on the and experience. opposite side. Being able to examine a single cell with its many molecular What has inspired you the components is the power of flow 11 How do campus researchers most during the course of your use the Cancer Center’s Flow career? cytometry; it will enable scientists Cytometry Facility? My family, and a few great to make major strides in finding The technology has applications teachers who were responsible for cures and answers for incurable across all areas of biology. We my interest in science. However, diseases. Flow cytometry and offer technical assistance and the research community here fluorescent image technology cellular analysis to investigators is a never-ending source of will be essential in determining in more than 30 campus inspiration when they work with why some cancers are more departments. We have experience us to develop new methods aggressive than others; they with many applications and are and creative ways to use our are likely to dissect the immune involved in developing many technology. response to world plagues like others. Our users have access to AIDS, leading to an effective all of this experience. vaccine.

11 David Gustafson, PhD, led the team that developed CHESS at UW-Madison’s Center for Health Systems Research and Analysis.

MilestoneCHESS University of Wisconsin And beyond the scientific about who will use and benefit professor emeritus David information, we needed practical from such systems. For example, Gustafson launched information, like how and when to our work has demonstrated that the development of the tell our children about this. It was all kinds of people—regardless of Comprehensive Health Enhancement Support System a very, very difficult time. Once income, education or experience (CHESS), a computer-based my wife and I got through this with computers—will use these system of integrated services experience, several of us started systems if given the opportunity. designed to help individuals working on a computer system We’ve also found that our cope with a health crisis or specifically for women with breast program can enhance the doctor- medical concern. cancer and their families called patient relationship. Oncologists CHESS—the Comprehensive have consistently told us their What inspired your research Health Enhancement Support patients come in with more into using technology-based System. It has now been used relevant questions and have better health education and support in helping cancer patients? by thousands of women, and just clinical visits when they have I have always been interested in last year it was translated into access to high-quality information Spanish. and support. education how people make health-related decisions. The first work I did was in mental health, using computers Are there other CHESS What is the future for using new programs besides the breast media technology to improve as a tool to help people at risk for cancer module? outcomes in cancer care? suicide; then to help middle and We have CHESS programs on There are so many ways that it high school students be more prostate and lung cancer, which can go. One of the biggest issues successful at school. I’ve always include an additional emphasis is making technology usable felt that giving people accurate, on caregivers. We also have a when people need it. Currently, up-to-date information, tools they tobacco cessation module and are many people use CHESS from can use to help make decisions, developing a module for parents laptops—so it is somewhat and the support they need, is with a child going through a bone portable. But we need to have it critical to making good choices. marrow transplant. even more mobile, using devices In 1990, this need for information such as Smart Phones which are How has CHESS research came crashing home when my part of everyday life for so many affected the way cancer people now. wife was diagnosed with breast patients receive care? cancer. Here I was, working Numerous clinical trials have We need people to get the in health decision-making my demonstrated that CHESS can information, support and coaching entire career, and yet when that improve a variety of outcomes, they need—where ever they are, diagnosis came, it was as if we when coping with a cancer instantaneously. So people waiting were both lost and unable to diagnosis. These include quality for test results won’t need to sit think clearly. We had so many of life, emotional well being and by the phone, they can get them questions—but didn’t even social support. This work has through a web-enabled phone as know what questions to ask. We inspired innovative internet-based soon as they are ready. We need wanted to know the best course programs to help people facing to make technology so easy to of treatment based on all the other health crises as well. use that it really is part of everyday scientific evidence out there, but life—making a real difference got different points of view from I think our work has also whenever and wherever people different providers. challenged some early stereotypes need it.

12 CHESS G ustafson, david PHD

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judy RN , MS D e muth, category

14 UW Cancer Clinics Manager Judy De Muth, RN, MS will be retiring this year after more than 30 years in cancer care.

MilestoneComprehensive Cancer Care Since 1974, Judy De Muth has developed here and then see that been wanting to stop and tell me been actively involved in cancer drug or drug combination become that 10 years ago—when she care and all but four of those part of standard therapy. was first diagnosed and about to years have been in manage- undergo chemotherapy—she was ment. Change has remained a Can you tell us what you constant for De Muth; she has so distraught and I had taken her have learned during your time seen many changes in health into a room and listened to her at UW? care delivery, drug development fears and concerns. She explained and technology throughout From a nurse manager that I had been so helpful to her her career. perspective, I have learned about and she wanted me to know that. the various aspects of managing It meant so much to me to know How has the way cancer care an area that has grown from that I had made a difference for is provided evolved throughout one to five clinics. With that someone. your career?

came opportunities to develop treatment

There have been many changes N ame budgeting skills, mentor staff, What is your one wish as during my 30 years in cancer care. plan and manage four remodeling cancer research and treatment For example, the change from projects. I’ve learned how to advances in the next few years? administering chemotherapy on derive satisfaction for patient There are really two areas that I the inpatient units to an outpatient care through the hard work and would like to see expanded. One setting has greatly increased. dedication of the clinic staff. is to continue to educate society Today, most treatment happens in about the risks of cancer and the clinic. The number of available From a nurse perspective, I’ve how people can reduce their risks chemotherapeutic agents has learned about courage, family by taking personal responsibility grown tremendously. We now relations and how serous illness for their health. Another is to 15 have more agents and more drug can adversely affect a family or have better access to cancer combinations available to treat pull a family together. I always education, care and clinical trials a wide variety of cancers. In the admire the hope and strength of for underserved populations. area of supportive care, we now will our patients display. I believe have better anti-emetic agents, I have learned many life lessons Do you have wonderful growth factors that support the from our patients. retirement plans? bone marrow, as well as increased I am excited to be able to spend social work, health psychology, You have seen many cancer more time with my family. My girls patients over the years. Are nutrition and integrative medicine live out of state and I would like to there any particular memories be able to visit them more often. support services. that you wish to share? My husband travels a lot and I am I have been touched by many What sets the UW apart from looking forward to accompanying patients and families. There have other cancer centers in treating him on some of these trips. With been tears of joy and sadness cancer patients? my passion for cooking, I am over the years. Once, I ran into First, we are a comprehensive looking to take more advance the mother of one of my former cancer center, providing patients classes. And lastly, I would like to patients and she introduced me with state-of-the-art clinical trials, explore my options for volunteer as the patient’s nurse as she bench research, teaching and work. clinical care. For instance, it is gave me a big hug. Recently, a exciting to have participated in a patient stopped me in our clinic clinical trial for a drug that was waiting room. She said she’d

15 Rebecca Marnocha, PharmD, leads the Pharmaceutical Research Center.

MilestonePharmaceutical Research Center The Pharmaceutical Research While the PRC program serves the Cancer Center and the level Center, under the direction of all clinical drug researchers at of UWHC institutional support that Rebecca Marnocha, PharmD, UWHC, its association with the has made the difference. ensures the safe and ethical Cancer Center is unique in its level provision of investigational Please tell us more about your study drugs to research of commitment, formal relationship new role within UW School of subjects enrolled in Cancer and in the breadth and depth Medicine and Public Health. Center clinical trials. of its services. PRC actively participates in the Cancer Center’s The Director of Clinical Research position was created to make Can you explain the role of Experimental Therapeutics the Pharmaceutical Research research program, is involved better connections between the Center (PRC)? with numerous Cancer Center School of Medicine and Public The mission of the PRC is to committees, supports the Cancer Health (SMPH), UWHC and UW ensure investigational and study Center’s drug list database, Medical Foundation (UWMF) and drugs are safely and ethically provides drug distribution services to advance clinical research at provided to people enrolled in for qualifying studies within the UW. I am excited about serving clinical drug trials within UW in this new capacity and to be education Wisconsin Oncology Network Hospital and Clinics (UWHC) program and serves as a liaison a change agent for the global and the Cancer Center. We also to the Cancer Center for research infrastructure. educate and train health care infrastructure and UWHC issues. I will be responsible for fostering providers about investigational positive working relationships, drugs, clinical drug study design What sets the PRC apart from optimizing operations, assuring integrity and human research similar facilities in the United effective and efficient connections regulation; ensure drug research States? and unifying strategic plans within protocols proceed optimally A quality pharmacy-based the clinical research infrastructure through the UWHC medication research support program is an of the SMPH, UWHC and UWMF. use system and in accordance integral factor to any institution’s I’ll be working to achieve a center with all federal, state, institutional success in conducting clinical of excellence by providing a safe, and sponsor regulations; and drug research. The PRC program ethical, regulatory compliant, continually refine and expand our at UWHC has been identified resource sensitive, fiscally services to meet the needs of the as a model service by many responsible, efficient and effective research community. external agencies and has been instrumental in creating UW’s clinical research environment. To accomplish its goals, the PRC successful research infrastructure I will also be an infrastructure offers study design assistance, environment. Compared to many consultant to the Health Sciences manages all aspects of drug academic research centers, the Institutional Review Board, the handling and accountability, PRC program is among the largest Office of Clinical Trials and the creates informational drug but its size is not what makes it General Clinical Research Center monographs for health care unique. Rather, it has been the and a formal liaison to the Cancer providers, engages in training and integration of the PRC program Center. quality assurance activities and within the UW clinical research provides a 24-hour a day, 7-day infrastructure, including a week research pharmacist on-call service.

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PHD D ove, william category

18 William F. Dove, PhD, is the program leader of the Cancer Genetics program.

MilestoneCancer Genetics William F. Dove, PhD, of the central gatekeeper for colon aren’t perfect. So colon cancer McArdle Laboratory for Cancer cancer. When these animals is among the most common Research, leads the Cancer develop intestinal tumors, we cancers. But in terms of the Genetics program, which can study how other genes and numbers of cell divisions that go involves research in 24 different labs on the UW-Madison environmental factors interact with on, it’s quite remarkable that colon campus. the disease. What changes make cancer doesn’t develop every year the cancer more severe, and what in every person. You’re the director of the changes make it better? Cancer Genetics program. What might such research mean What is genetics? How might such an for early detection? You may read about scientists understanding lead to We are identifying molecules that finding a gene for colon cancer, treatments? are associated with the tumors Sometimes we’ll see that we have and accumulate in various body or for breast cancer. What that research really means is they’ve found a a more severe cancer when the fluids, including blood serum. N ame gene where a mutation makes a mutation inactivates the molecule. These molecules give us a highly big difference. But it doesn’t mean This is called loss of function. sensitive way of screening for that breast cancer involves only Then we say, well, perhaps if tumor-bearing animals versus that single gene. A cancer involves we supply that function, we can normal animals. many genes, perhaps thousands make it better. This gives us a very Right now there are not enough of genes. concrete lead for a kind of therapy that could be developed. trained gastroenterologists to The basic science of genetics handle colonoscopies for the For instance, we’ve found there’s whole population over 50. Since seeks the connections between 19 molecules that carry out a an enzyme, a phospholipase, people give blood samples when process, and a phenotype, or the that’s secreted within the colon, they have a physical, if there were expression of that process. Every but not from the tumor, from a blood serum-based test, it might gene can be thought of in terms neighboring healthy cells. When become a less invasive form of of the molecule that it codes for. it’s active, tumors grow more early detection. When you have a mutated gene, slowly. So perhaps when this you therefore have a mutated product is diminished, replacing it Is there anything you want to add about this program? molecule and so a changed could prove therapeutic. Research across the Cancer phenotype—in this case the Why is colon cancer so Genetics program is drawn cancer phenotype. common? together by the intersection The intestinal epithelium is the between classical genetics, Can you give an example of this most actively self-renewing tissue type of research? comprehensive molecular analysis In my lab, our research starts in a mammal. Every week we of genotype and phenotype, and with mutations in certain key have a new intestine, in terms biostatistics. Finally, at the end of functions called “gatekeepers.” of the cells that are present. A the day, research findings must So we have both a mouse very active turnover means a lot be tested at the human level. The family and a rat family that were of potential for error. There are a Healthy Wisconsin initiatives of developed here at the university number of protective mechanisms our School of Medicine and Public which have mutations in the to keep it from developing Health are very important in this. growths, but these mechanisms

19 Dr. Brad Kahl is the Director of the UW Lymphoma Service and Clinical Research Director for Hematologic Malignancies.

MilestoneClinical Research As a hematologist treating Are there any groundbreaking What will the future hold for many patients with lymphoma, initiatives on the horizon in cancer research? Brad Kahl, MD, finds his field hematology? The future lies in translating infinitely fulfilling. A clinical Historically, multiple myeloma discoveries in molecular medicine researcher searching for new was the worst possible blood into personalized cancer care. and better cancer treatments, cancer diagnosis. However, in the We are going to be able to test he can look his patients in the past five years there have been eye and tell them that he has a tumor cells from two patients who very personal commitment to several new treatments developed appear to have the same kind of improving their condition. for myeloma and several more cancer and see that the cancers are in development. No single are actually quite different at the How did you decide to become treatment may qualify as a true molecular level. Then we will be a hematologist-oncologist? breakthrough, but when all of able to select targeted agents My father died of chronic the new options are considered tailored to each individual. The myelogenous leukemia (CML) together, the progress in myeloma result will be better outcomes with when I was 12. Obviously, that is truly impressive. fewer side effects. It is going to be had a big effect on me. I went exciting to see this unfold. treatment to medical school unsure of Tell us more about your what kind of doctor I wanted to clinical research. Is there anything else you would become. During the second year, I focus on developing new like to share? we covered hematology, treatments for patients with When my dad was diagnosed the study of blood disorders, lymphoma, which is cancer of with CML, there were no effective and it all clicked. After that, the lymphatic system. There treatments. A few years after his there was never a doubt. are approximately 40 different death, some patients were cured kinds of lymphomas, so I find it with bone marrow transplantation. What sets the UW Paul P. a very challenging area. Much Now, virtually all patients with Carbone Comprehensive of my research has centered on CML can experience long-term Cancer Center apart in developing monoclonal antibody remission just by taking a pill a day providing cancer care? therapy, which has far fewer side and bone marrow transplantation Without a doubt, the cutting effects than chemotherapy. is rarely needed. Now that’s edge research and treatments progress. There is reason to be combined with compassionate, What challenges lie ahead for optimistic. individualized care that we offer. individuals involved in your I have seen many patients seek research? second opinions at other major Our understanding of what makes cancer centers and they almost cancer cells tick is outpacing our always come back, talking about ability to apply that knowledge how lucky they feel to have the to help cancer patients. There Cancer Center in their backyard. are a multitude of reasons why. The challenge is to take what is learned in the laboratory and rapidly apply this knowledge to benefit our patients.

20 kahl, brad MD

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Headline goes here senior category leadership

22 Senior Leadership (left to right): Norman Drinkwater, Daniel Mulkerin, Howard Bailey, Jane Wegenke, George Wilding, Paul Sondel and Patrick Remington The UW Paul P. Carbone Comprehensive Cancer center is wisconsin’s only comprehensive Cancer center.

Cancerleadership Center and administration Senior Leadership F. Michael Hoffmann, PhD Frank McCormick, PhD, FRS George Wilding, MD Patricia J. Keely, PhD University of California, San Director Shannon C. Kenney, MD Francisco Cancer Center Minesh P. Mehta, MD Norman R. Drinkwater, MD Hasan Mukhtar, PhD George K. Michalopoulos, MD Associate Director – Daniel L. Mulkerin, MD University of Pittsburgh Laboratory Programs Michael A. Newton, PhD Peter S. Rabinovitch, MD, PhD Henry C. Pitot, MD, PhD Howard Bailey, MD University of Washington Patrick L. Remington, MD, MPH Associate Director – Maureen A. Smith, MD, PhD, MPH Clinical Programs Larry Williams, MBA Paul M. Sondel, MD, PhD University of Alabama at Paul M. Sondel, MD, PhD Bill M. Sugden, PhD Birmingham Comprehensive

Associate Director – James A. Stewart, MD Cancer Center administration Translational Research Jane Wegenke, BS Richard H. Weindruch, PhD Advisory Board Members N ame Patrick Remington, MD, MPH George Wilding, MD Don & Marilyn Anderson Associate Director – DeEtte Beilfuss-Eager Cancer Control External Advisory Committee George T. & Joseph V. Simone, MD (Chair) Daniel L. Mulkerin, MD Sandy Schwartz Bryan Simone Consulting Medical Director Mary Carbone Paul J. Carbone, Co-Chair Allan Conney, PhD Jane Wegenke Diane Craig Chechik Rutgers University Associate Director – Administration Ilene Fielkow Susan J. Curry, PhD June Franklin 23 The UW Paul P. Carbone University of Illinois at Chicago John Frautschi Comprehensive Cancer Center Meg Gaines is governed by an Executive Daniel DiMaio, MD, PhD Al Goldstein Committee. This committee Yale University Mary Lou Birkett Goodfriend receives input from an External Forrest Hartmann David Harrington, PhD Hans & Marjorie Helland Advisory Committee comprised Dana-Farber Cancer Institute of academic leaders from Sara Hildebrand Patricia Howell across the nation as well as Mark Israel, MD Tom & Barbara Kilgore a regional advisory board of Norris Cotton Cancer Center community members. Kevin Koch Peter Jones, PhD Nancy Kreilick Executive Committee USC/Norris Comprehensive Phyllis Leach Paul Ahlquist, PhD Cancer Center Efrat Livny Howard Bailey, MD Charles & Marian Loeffler Søren M. Bentzen, PhD, DSC Theodore S. Lawrence, MD, PhD Paula Lundberg Paul J. Bertics, PhD University of Michigan Linda Nielsen George T. Bryan, MD, PhD Bill Nitzke H. Kim Lyerly, MD James F. Cleary, MBBS Louise Rusch Duke Comprehensive David L. DeMets, PhD Donald Ryan Cancer Center William F. Dove, PhD JoAnn Six Plesko Norman R. Drinkwater, PhD Sanford Markowitz, MD, PhD William Steinberg, Co-Chair Meg Gaines, JD, LLM Case Western Reserve University Susan Veatch Michael N. Gould, PhD Mary Wickhem

23 The Interdisciplinary Research Complex will be a powerful tool for advancing biomedical research on the UW campus.

DiscoveryInterdisciplinary research complex Medical and biological science The design of the building is are uniquely able to observe the is continually evolving, and the meant to encourage integration progress and effects of disease, presence of the next generation of and flexibility across disciplines; which often stimulates ideas biomedical research is dramatically to facilitate a creative exchange for additional basic science apparent on the west end of the of ideas. Currently under investigations. University of Wisconsin campus. construction are a three-story With an impressive footprint and base housing key facilities such Taking advantage of the a total of 663,430 square feet as state-of-the-art animal facilities translational research approach at completion, the emerging and innovative imaging technology means institutions are focusing Interdisciplinary Research and an eight-story laboratory more of their resources on Complex (IRC) will be yet another tower including two floors for teams of faculty researchers scientific milestone at the imaging/radiation sciences. This who are well trained in inter- and university. first tower, scheduled to open multidisciplinary investigation; in early 2008, will be dedicated scientists who can project the The facility will be a national to cancer research, regenerative success of laboratory discoveries showplace, according to Paul M. to patient care and who are

research medicine, neurogenetics, DeLuca, PhD, Vice Dean of the molecular medicine and excited about designing their UW School of Medicine and Public neurosciences. The completed explorations around finding very Health and Associate Dean for complex will eventually include real and human solutions. Research and Graduate Studies, second and third research towers. an innovative center designed to Institutions are creating remove barriers between basic Siting the building was essential environments, such as the IRC, and clinical research. to the vision. It is close to to provide investigators with the University of Wisconsin the tools, the infrastructure and “Our concept was totally visionary Hospital and Clinics, the soon- research support necessary to at its inception more than a to-be-opened American Family advance multidisciplinary research. decade ago,” says DeLuca, “now Children’s Hospital, the School of These resources not only facilitate others are applying the UW’s Medicine and Public Health, the moving research breakthroughs original vision and creating their Waisman Center, the UW School to clinical care, they also help own centers.” of Pharmacy and the William S. recruit and retain promising faculty. Ultimately, the discoveries The IRC’s essential purpose is Middleton Memorial Veterans Hospital. emerging from facilities such to inspire creative new ways for as the IRC will forever change scientists to pursue biological A growing number of major the way medicine is practiced, research and to apply their ideas academic medical centers have opening unimagined opportunities directly to problems clinicians face been embracing the translational to improve human health and everyday. This model, frequently research model. One obvious well being. described as translational benefit of translational research, research, is a relatively new according to the National Institutes approach to scientific discovery, of Health, is that basic scientists and one that wouldn’t have been give clinicians new tools for patient possible even 10 years earlier. care, and clinical researchers

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25 more than 250 faculty on the UW-Madison campus comprise cancer center membership.

Cancermembership Center The UW Paul P. Carbone Comprehensive Cancer Center brings together the efforts of more than 250 faculty from 55 departments and nine schools on the UW-Madison campus.

Cancer Center members participate in seven research programs, which optimize intra- and inter-programmatic research and facilitate efforts to apply discoveries to improving the care of cancer patients. Cancer Cell Biology Laura L. Kiessling, PhD To read more about our B. Jack Longley, MD research programs, please Program Leader: Miroslav Malkovsky, MD, PhD James S. Malter, MD visit www.cancer.wisc.edu. Paul J. Bertics, PhD Shigeki Miyamoto, PhD

membership Co-Leader: Deane F. Mosher, MD Patricia J. Keely, PhD Christopher J. Murphy, DVM, PhD Robert W. Nickells, PhD The Cancer Cell Biology Sean P. Palecek, PhD Program seeks to understand Donna M. Paulnock, PhD the signals that govern the Donna M. Peters, PhD Arthur S. Polans, PhD proliferation and invasion of Alexander L. Rakhmilevich, MD, PhD metastatic tumors. Erik A. Ranheim, MD, PhD Alan C. Rapraeger, PhD Caroline M. Alexander, PhD Jeff Ross, MD Richard A. Anderson, PhD Matyas Sandor, PhD Emery H. Bresnick, PhD Christine M. Seroogy, MD Richard R. Burgess, PhD Lewis G. Sheffield, PhD William J. Burlingham, PhD Nader Sheibani, PhD Wade A. Bushman, MD, PhD Igor I. Slukvin, MD, PhD Dongsheng Cai, MD, PhD Gary A. Splitter, DVM, PhD Nansi Jo Colley, PhD Xin Sun, PhD Charles J. Czuprynski, PhD M. Suresh, DVM, PhD John M. Denu, PhD John P. Svaren, PhD Sinisa Dovat, MD James A. Thomson, VMD, PhD Jens C. Eickhoff, PhD David A. Wassarman, PhD Frances J. Fogerty, PhD David I. Watkins, PhD Andreas Friedl, MD Jyoti J. Watters, PhD Michael K. Fritsch, MD, PhD Jon Pointon Woods, MD, PhD Daniel S. Greenspan, PhD Wei Xu, PhD Jenny E. Gumperz, PhD Majed M. Hamawy, PhD Jacquelyn A. Hank, PhD Colleen E. Hayes, PhD Peiman Hematti, MD Anna Huttenlocher, MD David F. Jarrard, MD

26 Cancer Control and Cancer Genetics Chemoprevention Population Science Program Leader: Program Leader: Program Leader: William F. Dove, PhD Howard H. Bailey, MD James F. Cleary, MBBS Co-Leader: Co-Leader: Hasan Mukhtar, PhD Co-Leader: Maureen A. Smith, Michael A. Newton, PhD MD, PhD, MPH The mission of the Etiology and The mission of the Cancer Chemoprevention Program This program aims to reduce Genetics Program is to develop is to determine the causes the risk, incidence and the capabilities of experimental of cancer and then translate deaths from cancer as well as genetic analysis to define the knowledge to develop enhancing the quality of life for causative pathways that affect and evaluate drugs, vitamins those living with cancer. tumor growth. or other agents to try to reduce the risk of or delay the Henry A. Anderson, MD Judd M. Aiken, PhD development of cancer. Sanjay Asthana, MD Alan D. Attie, PhD Timothy B. Baker, PhD Christopher A. Bradfield, PhD Farrukh Afaq, PhD Tara M. Breslin, MD Franco Cerrina, PhD Nihal Ahmad, PhD Elizabeth S. Burnside, MD Mark W. Craven, PhD Elaine T. Alarid, PhD Betty A. Chewning, PhD Norman R. Drinkwater, PhD Lisa H. Colbert, PhD, MPH George T. Bryan, MD, PhD Anne E. Griep, PhD Jason R. Gee, MD June Dahl, PhD James L. Keck, PhD William E. Fahl, PhD Michael N. Gould, PhD Lorraine F. Meisner, PhD Michael C. Fiore, MD, MPH Russell F. Jacoby, MD Brion J. Fox, JD Amy R. Moser, PhD Colin R. Jefcoate, PhD Dennis G. Fryback, PhD C. David Page, Jr., PhD Christina M. Kendziorski, PhD Ronald E. Gagnon, PhD Richard E. Peterson, PhD Minakshi Nihal, PhD Aaron M. Gilson, PhD Tomas A. Prolla, PhD Michael W. Pariza, PhD Albert C. Gunther, PhD Carol D. Ryff, PhD Henry C. Pitot, MD, PhD David H. Gustafson, PhD Eric P. Sandgren, VMD, PhD Linda A. Schuler, PhD, VMD Lawrence P. Hanrahan, PhD David C. Schwartz, PhD Vijay Setaluri, PhD Robert M. Hauser, PhD Lloyd M. Smith, PhD Vladimir S. Spiegelman, MD, PhD Robert P. Hawkins, PhD Michael R. Sussman, PhD Roger A. Sunde, PhD Susan M. Heidrich, PhD, RN Richard H. Weindruch, PhD Ajit Kumar Verma, PhD Paul R. Hutson, PharmD, RPh Brian S. Yandell, PhD Gary S. Wood, MD David E. Joranson, MSSW Weixiong Zhong, MD, PhD Douglas E. Jorenby, PhD Karin T. Kirchhoff, PhD, RN Bruce S. Klein, MD Betty J. Kramer, PhD David M. Kushner, MD Kristine L. Kwekkeboom, PhD, RN Diane R. Lauver, PhD, RN Yu Jim Li, MD Donna O. McCarthy, PhD, RN D. Paul Moberg, PhD Polly A. Newcomb, PhD Patrick L. Remington, MD, MPH JoAnne A. Robbins, PhD Michael L. Rothschild, PhD Tracey A. Schroepfer, PhD Ronald C. Serlin, PhD Stevens S. Smith, PhD Amy Trentham-Dietz, PhD David J. Vanness, PhD Sandra E. Ward, PhD Mark V. Wegner, MD, MPH Whitney P. Witt, PhD, MPH

27 Experimental Kyle D. Holen, MD Human Cancer Virology Therapeutics C. Richard Hutchinson, PhD Brad S. Kahl, MD Program Leader: Program Leader: Weiyuan John Kao, PhD Paul G. Ahlquist, PhD F. Michael Hoffmann, PhD KyungMann Kim, PhD Jill M. Kolesar, PharmD, RPh, BCPS Co-Leader: Co-Leader: Ilene D. Kurzman, EdD Shannon C. Kenney, MD James A. Stewart, MD Glen S. Kwon, PhD Garet P. Lahvis, PhD Researchers in the Human The specific aims of the Glenn Liu, MD Cancer Virology Program study Experimental Therapeutics David M. Mahvi, MD members of families of viruses Gerard J.D. Marriott, PhD Program are to identify novel that cause cancer in people— mechanisms of anticancer Joseph H. Matloub, MD Douglas G. McNeel, MD, PhD revealing the mechanisms by therapy and translate them to Daniel L. Mulkerin, MD which viruses predispose cells clinical applications, to perform Daniel Muller, MD, PhD to evolve into tumors and by initial human clinical trials Terry D. Oberley, MD, PhD dissecting the routes by which and to move new therapies to Manish S. Patankar, PhD viruses enter cells. disease-specific settings. Ronald T. Raines, PhD Scott R. Rajski, PhD Curtis R. Brandt, PhD Nicholas L. Abbott, PhD H. Ian Robins, MD, PhD Teresa Compton, PhD Daniel M. Albert, MD Joseph R. Robinson, PhD Robert J. Kalejta, PhD Mark R. Albertini, MD Arnold E. Ruoho, PhD Paul F. Lambert, PhD Hirak S. Basu, PhD Ben Shen, PhD Daniel D. Loeb, PhD David J. Beebe, PhD Eric V. Shusta, PhD Janet E. Mertz, PhD Helen E. Blackwell, PhD Paul M. Sondel, MD, PhD Robert Todd Striker, MD, PhD Reginald C. Bruskewitz, MD Santhanam Swaminathan, PhD Bill Sugden, PhD Natalie S. Callander, MD Jon S. Thorson, PhD John Yin, PhD Herbert Chen, MD Randal S. Tibbetts, PhD Joseph P. Connor, MD Anne M. Traynor, MD Hector F. DeLuca, PhD David M. Vail, DVM David L. DeMets, PhD Lynn Van Ummersen, MD Darin Y. Furgeson, PhD George Wilding, MD Samuel H. Gellman, PhD Jon A. Wolff, MD James E. Gern, MD Ellen M. Hartenbach, MD

28 Clinical Investigators Participating Across Programs

These faculty members contribute to the clinical research effort by recruiting patients to clinical trials, advocating the benefits of clinical trials to patients, managing the care of patients according to the guidelines of the clinical research protocols and analyzing clinical samples. Imaging and Radiation Paul M. Harari, MD Sciences Victor M. Haughton, MD Ruthanne Chun, DVM Steven P. Howard, MD, PhD Moo K. Chung, PhD Program Leader: Robert Jeraj, PhD Kenneth B. DeSantes, MD Minesh P. Mehta, MD Sterling C. Johnson, PhD Carol A. Diamond, MD Frederick Kelcz, MD, PhD John P. Heiner, MD Co-Leader: SØren M. Bentzen, John S. Kuo, MD, PhD Charles P. Heise, MD PhD, DSC Fred T. Lee, Jr., MD Mark B. Juckett, MD Leonard A. Levin, MD, PhD Catherine P. Leith, MB, BChir The Imaging and Radiation T. Rockwell Mackie, PhD Mary J. Lindstrom, PhD Sciences Program is focused Ernest L. Madsen, PhD Walter L. Longo, MD on improving early detection Mary Elizabeth Meyerand, PhD Peter A. Mahler, MD, PhD and staging of cancer as well Charles A. Mistretta, PhD Timothy D. Moon, MD Robert J. Nickles, PhD as developing strategies to Stephen Y. Nakada, MD Bhudatt R. Paliwal, PhD improve outcomes of patients T. Michael Nork, MD Rakesh R. Patel, MD Diane M. Puccetti, MD treated with radiation. Walter W. Peppler, PhD Marjorie A. Rosenberg, PhD Scott B. Perlman, MD M. Shahriar Salamat, MD, PhD William McChesney Adams III, DVM Perry J. Pickhardt, MD B. Lynn Allen-Hoffmann, PhD Aimen F. Shaaban, MD Mark A. Ritter, MD, PhD Jude W. Shavlik, PhD Gabriela G. Cezar, DVM, PhD Howard A. Rowley, MD Suresh R. Chandra, MD Richard A. Steeves, MD, PhD Bruce R. Thomadsen, PhD Sharon M. Weber, MD Richard J. Chappell, PhD Wolfgang A. Tome, PhD Onofre T. DeJesus, PhD Eliot C. Williams, MD, PhD Patrick A. Turski, MD Robert D. Woodson, MD Paul M. DeLuca, Jr., PhD Jamey P. Weichert, PhD Sean B. Fain, PhD Tracey L. Weigel, MD Jason P. Fine, PhD James A. Zagzebski, PhD Lisa J. Forrest, VMD Gelsomina Gilbert, PhD Thomas M. Grist, MD Susan C. Hagness, PhD

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C linical category leadership

Clinical Leadership (Front row – left to right): Vicki Banning, RN, B6/6 Inpatient Nurse Manager; Judy De Muth, RN, MS, Cancer Clinics Manager, Deana Jansa, RN, 30 Bone Marrow Transplant Manager. (Back row – left to right): Teresa Smith, RN, MS, Director – Oncology Services; Stephanie Orzechowski, RN, UW Breast Center Manager; Katrina Lambrecht, Interim Radiation Oncology Manager the cancer center’s focus is on the best care for patients with cancer; on research, education and prevention.

Cancercompreh enCentersive cancer care At the University of Wisconsin Cancer Clinical Services • Implemented primary nursing Paul P. Carbone Comprehensive Accomplishments FY 2006 model of care on the inpatient Cancer Center, the goal is to • Completed construction and oncology, hematology and offer excellence in care and opened UW Cancer Center bone marrow transplant units. service each time patients and Johnson Creek in October 2005. • Installed a new Tomotherapy family members visit, and to keep • Implemented new technology, machine in Radiation Oncology. improving every day. Varis Vision in Radiation • Implemented the Integrative Oncology—allowing clinic Oncology Program. Delivering on that promise requires to be filmless—streamlining a fervent commitment to quality and accelerating the flow of Cancer Clinical Services Goals and to the people, programs, clinical data. FY 2007 technologies and partnerships • Improved patient satisfaction in • Implement primary nursing that make it happen. To monitor the Cancer Clinics, Radiation model in all Cancer Clinics. T reatment

progress, we routinely measure Oncology and Breast Center. • Implement robotics program in N ame performance and compare it to The Gynecologic Oncology Radiation Oncology. nationally accepted standards and Clinic attained “Star Clinic” • Continue planning for EPIC best practices. We’re proud to be status. implementation in Cancer among those setting the standards • Detailed drawings for the Clinics in early 2008. and creating the best practices Radiation Oncology expansion • Complete planning for that others follow. project were completed. Radiation Oncology expansion • Chemotherapy Coordinating with first phase of the project to Council formed with the goal open in April 2008. to identify UW standards for 31 chemotherapy.

2005 Clinical Trials Statistics SUMMARY OF NEW CANCER CASES 2000-2005, UW HOSPITAL AND CLINICS Number of patients enrolled in all clinical trials: UWCCC patients...... 1296 750 Affiliate patients...... 352 TOTAL...... 1648 700 2005 650 2004 Number of trials open: 2003 Open to adults...... 237 600 Open to adults and children...... 27 2002 550 Open to children...... 19 2001 500 2000 Number of trials open: 450 Phase I...... 55 400 Small trials that test for overall drug safety, dosage and basic patient responses. 350 Includes Phase I/II and I/III studies 300 Phase II...... 122 250 Trials that look at the efficacy of the treatment and 200 its side effects. Includes Phase II/III studies 150 Phase III...... 105 100 Large scale trials that examine the long-term safety and relative success of a new treatment compared 50 to standard therapies 0 Head and GI GU Lung Non- Leukemia GYN Melanoma Female Peds Central Non-treatment trials...... 51 Neck Hodgkins Breast Nervous Lymphoma System

31 The UWCCC helps treat nearly half of all cancer patients in Wisconsin, through affiliate partnerships and outreach services.

Cancerregional partCenternerships Starting in 1989, the University advance cancer care and research These alliances mean University of Wisconsin Paul P. Carbone throughout Wisconsin and of Wisconsin physicians bring Comprehensive Cancer Center northern Illinois. treatment advances generally developed a regional network to only found at academic medical Through these partnerships cancer centers to patients in eight patients have access to the most regional communities. sophisticated treatment, clinical trials, patient education material By working together local and and second opinions. university health care professionals have a tremendous impact on the patients and families they serve. We celebrate their many significant events from 2005 – 2006.

UW Cancer Center, Aspirus Wausau Hospital, Wausau Undertook a joint venture with UW Cancer Center Riverview Hospital in Wisconsin Rapids to offer area services category regional patients unique opportunities for Wisconsin coordinated radiation therapy care. Was a major sponsor of the annual Be a Friend 4 Life event, raising awareness about the benefits of early breast cancer screening.

UW Cancer Center, Riverview UW Cancer Center, Hospital, Wisconsin Rapids Affinity Health System Became the first cancer treatment Wausau Affinity’s Appleton facility held its first site in north-central Wisconsin to offer cancer survivor’s day picnic in May the TomoTherapy HI-ART System of for survivors from the communities image-guided intensity modulated surrounding both UW Cancer Center- radiation therapy (IMRT). Also added a Affinity Health System sites. new medical oncologist/hematologist, Ron J. Kirschling, MD, FACP, to its Wisconsin Rapids medical team. Appleton Holy Family Memorial, Manitowoc With help from many community Oshkosh supporters created a Heritage Garden to provide a unique setting for patients, family, Manitowoc staff and visitors.

UW Cancer Center, Johnson Creek Introduced Intensity-Modulated Radiation Ended a successful first year with multiple awards Therapy (IMRT), an advanced form of high- recognizing its patient-centered design. The new precision radiotherapy that uses computer facility is a partnership among Fort HealthCare, controlled X-rays to deliver precise Watertown Area Health Services and UW Health. radiation doses. Recognized by the Commission on Cancer of the American College of Surgeons Madison for the quality of its comprehensive, multidisciplinary patient care. UWCCC Johnson Creek

FHN Leonard C. Ferguson Cancer Center, Freeport, IL Received the American Cancer Society’s Beloit Memorial Hospital, Beloit “President’s Award for Mission Delivery— Beloit Developed plans in 2006 for infrastructure Education in the Community” for “Plant it improvements in 2007, including Pink—Hope Blooms for Breast Cancer,” an remodeling their treatment room, event to increase community awareness of upgrading record and verifying software, the importance of early detection of breast and providing new office space for their cancer by selling 25,000 pink tulip bulbs. 32 Illinois radiation oncologist and dosemitrist. Freeport

Indiana Copy

Contributionsfinancial information

33 donors listed on the following pages are from july 1, 2005 - June 30, 2006.

Cancerdonors a nCenterd gifts The University of Wisconsin Paul P. Carbone Comprehensive Cancer Center would like to thank all donors who help our organization maintain its leading role in innovative research initiatives, compassionate cancer care and education for the public and health care professionals.

Donors listed on the following pages are from July 1, 2005 - June 30, 2006.

$100,000 & Above Matthew & Heather Morris George & Patricia Bryan, Jr. C. Daniel & Margaret Geisler Donors Charles & Carolyn Mowbray Frank & Bonnie Burgess Genentech Incorporated Anonymous Our Hope of Burlington, Inc. Thomas & Barbara Callahan General Beverage Sales Co. Frieda S. Cohn Estate Pfizer Foundation, Inc. Cancer Sucks Golf Outing William & Julie Gladbach Roger DeMeritt Roger F. Plantico Estate Alan Caplan Memorial Fund Albert Goldstein & Marie Flanagan Leyer Estate Jeffrey & Peggy Post Marian Caracciolo Phyllis Lefcowitz Midwest Athletes Against Phil Reader Mary Carbone Grand Chapter Order of the Childhood Cancer Round of Hope Golf Outing Paul P. Carbone MD Eastern Star of WI Irene Newman Donald & Diana Ryan Memorial Foundation Grand Hyatt Las Vegas Jim Ryu & Helen Lho Lloyd Carlson Mary Granger Prostate Cancer Foundation

University of Wisconsin Russell & Carol Schuler Al Carruthers & Colleen Adams Judith Green Medical Foundation Diane Schure Estate Circle of Hope Bracelets Michael Gregor and

G ifts State of Wisconsin Department Marvin & Mildred Conney Olga Grkavac

D onors of Justice Gordon & Sigrid Connor Glenice Halfman $10,000 - $99,999 Paul & Judith Thomsen Co-op Network Sue & Eugene Hanmer Memorial Donors Tomorrow’s Hope, Inc. Cornerstone Advisors, Inc. Golf Outing Amgen Foundation UW Hospital & Clinics Authority Credit Union Executives Society Edward & Nancy Hanson C. Berwyn & Paula Anderson, Jr. Wendy Will Case Foundation (CUES) Lewis & Lorraine Hanson Donald & Marilyn Anderson J. Martin Wolman Creditor Resources, Inc. Haraldson Brothers Open Adlynn Balfanz John Cullen Robert & Mona Harty Paul & Amy Carbone CUNA Mutual Insurance Group Mary Ann Henning Memorial Fund Choose Hope, Inc. $1,000 - $9,999 Donors Custom Main Services of Nelson & Vera Hicks Charitable Cindy Crawford Daniel & Eleanor Albert Madison, Inc. Foundation Gretchen & Andrew Dawes James & Kathryn Allen The Cutting Edge Brian Howell Lung Cancer Charitable Trust Alliant Energy Foundation Patrick & Kathryn Daly Golf Outing Donna Fox Susan Allison Peter Davis Daniel & Patricia Huber John J. Frautschi Family Altura Credit Union Roland & Mary Jane Day Philip L. Hunkel Memorial Foundation American Association for DLA Piper Rudnick Gray Cary Research Fund Friends of Tim Eagle Cancer Research US LLP Insite Selection Services, Gammex, Inc. American Midwest Equipment William & JoAnne Doppstadt International Golf Fore Wolfe & A Cure Company Roger Duhl Matilda Joseph Estate Grand Aerie Fraternal Arnold & Sally Anderson Gordon & Ruth Dunn Fred Johnson Order of Eagles Anonymous Stephen & Melanie Dvorak Kent & Sandra Joranlien Greater Richland Area Cancer Aring Equipment Co., Inc. John Dweck Kim & Margo Kalepp Elimination, Inc. Melissa Arnold Memorial Charles Eis Brian & Mary Kaye Green Bay Packers ASCO Lisa Elkin M. Patricia Keller Craig Hanson Paul Aspinwall John & Gloria Etter John Kelly HEADRUSH Badger Jim Beam Club Sharon Evensen Terence & Mary Kelly Hedberg Foundation, Inc. Robert Bain George Fait Kikkoman Foods Foundation, Inc. Rebecca Higgins Robert W. Baird & Co. Gordon & Judith Faulkner Thomas & Barbara Kilgore Ruby E. Jonas Estate Foundation, Inc. Fred Fenster Lois Kilmer Audrey Keck Robert Barranco Russell & Janet Ferris Markus Klebermass Dr. & Mrs. Hugh A. Kennedy Eileen Bauman V. Kirt & Dixie Fiegel Dorothy Klink Foundation Allan & Paulette Beerkircher First South Credit Union James & Dolores Kohn Bernard & Sally Killoran Joel & Kathy Belaire F.J. Turner High School Howard & Avis Kolpin Fund LaVaier Kliefoth Estate Thomas & Marlene Benzmiller Boys Basketball Team Michael Kosmak Memorial Nora S. Korwitz Estate Robert & Donna Betzig Robert & Angela Flannery Charles & Patricia Koval Joan Kuypers Michael & Bonnie Bogen Wesley & Ankie Foell Donald & JoAnne Krause Steven C. Leuthold Douglas Brown Forum Credit Union William & Christine Krugler Family Foundation Richard & Beverly Brown Joseph Gajdos Kris & Penelope Kubly James Meyer Robert & Susan Brown Barbara Gambino Vicki Lord Larson

34 Judi Lepofsky Frank & Margaret Siegel Gary & Beth Leverton Robert Siewert Memorial Fund Earl Levitt Smart Motors, Inc. Irving Levy Mark Solverud Liberty Mutual – Dovers Accounts Spectrum Brands Payable Springs Window Fashions, LP Lenore Lum George & Mavis Steil, Sr. Lung Cancer Memorial Golf Outing Joseph & Jamie Steuer M.G.R. Foundation Emily Stoddard Madison Curl for Cancer Bonspiel Steven Stoddard Marshall & Isley Corporation Mary Kay Strachota Eugene Mayernick Janis Strauss Nellie McCannon Michael & Mary Jo Stroh Robert & Emily McKay Robert & Martha Suter Benstan Meils Thaddeus Suter Deloris Meiners James & Deborah Swanson Richard & Pat Moll Lewis & Diane Taynton Agnes Moore TD Securities USA, LLC Cynthia Morgan TDS Telecom Corporation Daniel & Victoria Mulkerin John Thomsen Multi-Media Productions USA, Inc. Willard Thurlow National Credit Union Foundation, TomoTherapy, Inc. Inc. Trackside Charities Foundation, Frederick Nelson Inc. Joseph & Stephanie Nichols Anne Traynor North Bristol Sportsman Club Unity Health Insurance North Island Credit Union The University Book Store Dennis & Lori O’Donnell Margaret Van Alstyne Robert & Lois Olson Edwin & Susan Van Boxtel Sue Oppenheim Trust J. Paul & Lois Van Nevel Nancy Orbison Denis & Laura Vogel Parts Now! LLC Walter Vollrath, Jr. Jeffrey Peck & Lisa Resek Peck Mary Jane Voss Pictured above is the family of Sam Mobile. The Sammy Cup Golf Outing is Janice Pennau Revocable Trust Florence A. Walsh Fund held annually in memory of Sam in Sycamore, Illinois. The UWCCC received Pepsi-Co Foundation John & Jacalyn Warczak $4,600 for lymphoma research from the event. Charles & Barbara Perkins Andrew & Judy Waterman Jane Perlman Tracey Weigel Russell & Susan Doty Homer Howard Robert Pettibone Frances Weinstein Harold Drecktrah Charles & Julia Howell Richard & Sandra Pfahler Cheryl Weston John Duncanson Jay & Patricia Iams Daryl Pieper John & Joyce Weston Eagle School of Madison, Inc Brice & Julie Jackson Kenneth & Janet Pike Nancy Wild Memorial Laurence & Judith Eiseman, Jr. Ardys Janke Dan Pohlman David Wilkinson Diane Elson John Jardine Scholarship Fund Poynette Curling Club Windsor Garden Walk Donald & Susan Emerich JFK Design Build, Inc. Provident Credit Union Wings Over Wisconsin, Inc. William & Gail Engler, Jr. William & Linda Johnson Charles & Patricia Quentel, III Wisconsin Dells Area Neil Epstein & Arlene Margolis Dawn Jorgensen-Heiser Susan Batt Racine United Fund, Inc. Fairwinds Credit Union Joseph & Barbara Kachelski The RCZ Revocable Trust JoAnn Wollersheim Bernice Faltersack Barbara Karlen Loeta Reed-Cress Workers Credit Union John Fatura Wendy Kayser Herbert Reif James & Jacqueline Wrycha Gary & Mary Feldt Howard & Mary Kidd G. Robert & Marjorie Remiker Gail Wurtzler Robert Fey Gerald & Vicki Klump Donna Resek Xeric Federal Credit Union Gerald & Penny Fink Sharon Knoop Elliott Resneck Sol Zaichick First Business Trust & Nancy Kreilick Gordon Rice Erwin & Joan Zuehlke Investment Services Robert & Candace La Macchia Ronda Richards Emil & Gail Fischer Charitable Paul Lambert Richard & Mary Kay Ring Gift Fund Gayle Langer Roche Laboratories $500 - $999 Donors Marshall & Lisa Flax Nancy Layng Richard & Nancy Roloff Ronald & Sonja Ahlert George & Jennifer Forbeck Phillip & Arlene Lee Wanda Rood Lester & Joanne Ahrens Four Leaf Lawn Care, Inc. Leeds Charity Fund Mary Ann Rosar Arthur Arveson Kurt & Margaret Frehner Mark & Marian Lefebvre Royal Oaks Elementary School Peter Bales Doris Gerndt Richard & Joan Leffler Steven & Julie Rucinski John & Bernadette Beam Lawrence & Jean Gohlke Marvin Levy Louise Rusch Bob & Cathie Beckwith Irwin Goodman & Christopher & Melissa Livingston Wendell Sagendorf Niles & Linda Berman Robert Goodman Charles & Marian Loeffler Gregory & Susan Samuels Wendy Bicknell John Gould, III Jay & Janet Loewi Albert Schams Robert & G. Kathryn Bray Mr. & Mrs. Bernard Grommes Willis Long Schering-Plough Foundation, Inc. Donald Brieger Forrest Hartmann Lawrence & Lee Ann Lord George & Joan Schiller Bristol Myers-Squibb Susan Haviland Paul & Tracy Luber Nancy Schoenmann Thomas & Elizabeth Butterbrodt Donna Hellenbrand Thomas & Irene Lynch Kay Schoon Cedar Grove Area United Fund Judy Hepp Joanne Maass Judith Schuster William & Jean Cencic Keith Hernke Madison Curling Club Carolyn Schwartz Chicago White Metal Casting, Inc. Michael Higgins Kristine Mattson Sedlock & Associates Donald & Wanda Chisholm Hilldale Land Company, LLC MECU of Baltimore, Inc. Michael See Leonard Cordaro Charles Hobbs Memorial Margaret Metcalfe Jeffrey & Rohy Seltz Dane County Title Company, Inc William & Mary Holewinski Helen Morrell Shamrock Club Parade Committee Decision Strategies International Harold Holt Kurt & Annette Mueller

35 Bank-Fund Staff Federal Credit Union Sylvia Banville Diane Barnidge Barron Community Fund, Inc. Richard Barry Robert & Barbara Bartholomew David & Inez Baskerville Thomas & Sally Basting Hirak & Aparajita Basu R. Alan Bates & Jessica Southworth Bates Bernadine Bauer G. Brian Bauer & Rebecca Bull Kurt & Anne Bauer Michael & Colleen Baughn Bruce Bauman Daniel & Karen Baumann David & Diane Bautsch Frieda Baxter Shown are participants from the 2006 Wisconsin Dual Sports Spring Charity Ride held in Wabeno. This two-day Barbara Beale ride, throughout the Nicolet National Forest, raised $7,900 for cancer research. Henry & Lorraine Beaster Barbara Beck John Beck $500 - $999 Donors Georgie Toms Memorial Anita Allison Robert Beck Bernice Muth Kenneth Townsend Thomas & Carla Altepeter H. William Becker Michael Neill Sarita Trewartha Charles Amato Mary Becker Stephen Nelson Jerry & Denise Tribbey Joey Amberg Mildred Becker Nevada CUES Council James Twesme Ameren Services Ryan Behling John Niebler Rich Van Duzer & Terri Gorsett American Family Mutual William Behling Norbel Credit Union Gerritt Van Wagenen Insurance Company Joan Behr James Norman David Vergeront American First Credit Union Calvin & Joy Beisswanger Stan O’Keefe Martha Vestling Amtelco Dennis & K. Regina Bell Patrick & Amaria O’Leary Stuart Vonderloh Carol Anchor Craig & Christie Bender Oregon Washington CUES Richard Vowles Josef & Karla Anderegg Thomas & Lynne Bendt Patrick Cudahy Incorporated Ruth Wagner Bradley Anderson Bennett & Bennett CPA’s, PA Christopher & Virginia Pedersen Robert & Elaine Waldo Edith Anderson David & Cynthia Beno Edward & Judy Peirick Donna Weis Howard Anderson Douglas Berge Merle & Barbara Perkins Penelope Williams Louis & Marguerite Anderson Bruce & Tracy Bergum John Peterson Nan Wilson Nancy Anderson Martin Berk Robert Placek Wisconsin CUES Council Paul & Mildred Anderson Leonard & Norma Berkowitz James Potter & Jean Porter WI Region of the Model A Matt & Rita Andis Morton & Barbara Berkowitz Robert & Patricia Porter Restorers Club. Inc. Frank & Helen Andrekus Robert Bernardoni & Quad/Graphics, Inc. Winneconne Schools John & Faye Andrews Charlotte Doherty Bruce Ravid WIPFLi Andrews Federal Credit Union Stephen & Anne Bernsten, Jr. Maurice & Arlene Reese Marilyn Wolf Tracey Anton Barbara Besadny Grace Fleming Reinhold Trust Kenneth Wood Mona Antonelli Jacques Besant & James & Dawn Reininger J. Patrick Wright Michael & Rima Apple Patti McGinnis-Besant Mark & Karla Ritter Gary Young & Linda Roberson ARC Milwaukee, Inc. Bethpage Federal Credit Union James & JoAnne Robarts John Zimdars, Jr. Thomas Archdeacon & Persis Betts Eileen Roesler Muriel Zwickey Marilyn Lavin Beverly Beutel Steven Rough & Charles & Patricia Armour Marie Bewick Jody Schwerdtfeger Rough Perry Armstrong Jr. $100 - $499 Donors Ruth Ann Beyers Pauline Rusch Cathleen Arnold BFG Federal Credit Union Creed Abell Adam Ryan Mary Arnold Sean & Stacy Bidinger Seymour & Shirley Abrahamson Ronald & Mary Lee Ryan Mary Beth Arnold Robert & Ann Bielefeldt ACE Precision Castings, Inc. Suzanne Barnes Ryden Roland Arteaga Lawrence & Rita Bierman ACE Sauk Prairie Raymond Scheid Memorial Association Forum of Chicagoland Brian Bishop Phyllis Aceto Peter & Colleen Schmitz Robert & Janyce Aura Larry & Ruth Bishop Robert & Beverly Acker Paul Schoemaker David & Margaret Austin William & Kathleen Blair William Ackermann Arthur Shannon Jonathan & Susan Axelrod Thomas & Paula Blankenheim Leroy Adamski Gwendolyn Sharratt Mary Ayton Jacqueline Blatchley ADS Mechanical LLC Frank & Helen Shishilla Carl & JoAnn Bachhuber Sandra Blauert Advanced Building Corporation Alice Slopa Russell & Marjorie Bachman Kermit Bliss Aerial Properties, LLC SOFCU Community Credit Union Richard & Nicole Backhaus Beverly Block Jay & Sarah Affeldt Philip & Mary Jane Southworth Badger Inventory Service, Inc. Kerry Block Thomas & Carolyn Agard Jay & Lou Ann Spaanem Badger Ridge Middle School Blue Flame Credit Union J.F. Ahern Company Eloise Sparger 7th Grade Class Andre & Anna Blum Margaret Ahlgren Suros Surgical Systems, Inc. Erik & Elizabeth Bade BMI FCU Alabama Council of CUES Target Specialty Products Tom & Doreen Badtke Doris Bock Arnold Alanen & Lynn Bjorkman Benton & Mary Taylor Duane & Beth Baer Catherine Bock-Weiss John & Ann Albert Tectura Dennis & Naomi Bahcall Roland & Mary Boeding Patricia Alea Television Wisconsin, Inc. Joel & Leigh Bahr J. Richard Boelk Peggy Alf WISC-TV 3 Curt & Carla Baier Michael & Mary Bohn All State Lines, Inc. Orville & Ruth Thiel James & Mary Baliker Lester & Diane Boles

36 John & Marian Bolz Jeffrey & Jane Carlson Credit Union Executives Council Michael & Janet Dow Robert & Anne Bolz Joseph Carlson & Margaret Nides – Illinois Steven & Kristie Dowden Boncosky Oil Company William & Louise Carr Credit Union of New Jersey Patrick Downing John & Theresa Boncyk Amy Carroll Credit Union ONE Ron Downing Steve & Nancy Books Bruce & Kristin Carroll James & Karel Cripe Sean & Jacqueline Doyle Harold Borenstein Edythe Carroll-Clarke Gerald & Phyllis Crohn Doylestown Charities Fund Donald & Helen Botsford Virginia Cashbaugh Mary Cromey John & Josephine Draeger Andrew Bowden Andrew & Susan Cassady CUES Illinois Donald & Carole Draheim William Bowen Arthur & Beverly Castro CUES Michigan Council Gordon & Maureen Drake Teresa Bowers Dale Cattanach CUES Southern California Alice Draves Quentin & Inez Boyken Cedar Creek Settlement – Arizona Joseph & Laura Dresen Richard & Connie Brachman, II Merchants Assoc., Inc. Mark & Carol Cullen James & Jane Drill The Brand Research Company Center for Advanced Studies in Ralph Cullen W. Scott & Nanette Dryburgh, III Carole Brandt Business, Inc. Timothy Cullen Peter & Barbara Duffy Chuck & Linda Brei Central Credit Union of Michigan CUNA Credit Union Paula Dulin-Brinson Lyle & Carolyn Bremmer William Cerny, Sr. CUNA, Inc. John & Jean Dunlop Brennan, Steil, Basting & Kenneth & Gudrun Chadwick CUNA Mutual Insurance Group Richard Duran, Jr. MacDougall, S.C. George & Agathe Charbonneau Executive Benefits Dept. Loyal & Bernice Durand Laura Brenner Diane Craig Chechik Robert & Mary Cunningham Stanley DuRose, Jr. Stephen & Mary Brenton Oakley & Christine Cheney, III Susan Cunningham Dutch Point Credit Union, Inc. James & Jacqueline Bretl The Cherry Corporation Thomas & Colette Curran Duval Federal Credit Union F. Anthony & Susan Brewster Ramon & Janet Chesner Robert & Jean Curtin Kenneth & Janelle Dvorak Jerry & Carole Briesath Larry Chiang James & Terri Curtis Gary & Cindi Dyke Harland Bright Teresa Chiaverotti Thomas Curtis Leonard Eager & Wesley & Sonja Brill R.J. Chmielewski Ruth Curtiss DeEtte Beilfuss-Eager William & Joan Brock Lyle Christenson Custom Alloy Light Metals, Inc. Kathleen Easland Phillip & Marilyn Brockish Raymond & Memee Chun Elsie Czehno Virgil & Betty Eaton Robert Brockman Gilbert & Helen Churchill, Jr. Alessandro & Renee D’Agaro Gregory Eckert Janet Brodhead Dan & Sue Cira Frank & Patricia D’Angelo Warren Eckstein & Bruce Brooks N. Michael & Lenore Cira Lynette D’Mello Barbara Luedtke-Eckstein Susanne Broome Citadel Herbert & Brenda Dahlman Jim Edlebeck & Ann Hintz Ronald Brovelli Citizens First Credit Union Dan & Jean Dahm James & Suzanne Effland Cameron & Sybil Brown Roger & J. Loretta Clark William & Lynn Dailey Paul & Sonia Egbert Carlton & Helen Brown Mr. & Mrs. James Cleasby F.C. & Joan Daniels James & Sharon Egger David Brown Jeanne Cleland Michaela Daniels Hyam & Sheila Eglash Sara Brown Thomas & Phyllis Cline, Jr. Edward Danz, Jr. Bruce & Rosemary Ehr John Bruce & Maureen Hall James Clum Joseph Darcey James Ehrle Walter & Ellen Bruce Coast Hills Credit Union Robert & Donna Darling Ray Eiben & Marilyn Myers Christopher & Beth Bruns John & Lois Coleman Edmund & Susan Dashcund Marc Eisen & Connie Kinsella Richard & Mildred Brus Aldona Collani Margaret Daubenspeck Eisenberg Law Offices, S.C. Dennis & Barbara Brush Robert & Patricia Collins Paul Davenport James & Jan Eisner Randy & Linda Bryden Robert Colvin Richard & Rose Mary Davis Jane Eisner Frances Bubolz Francis & Barbara Comella George & Carol Dawes Henry & Laurel Ellingson William & Signe Buchholz Community America Credit Union Helen De Groot Beata Elliott John & Jackie Buddle Community Educators David & Kathryn De Mets Charles & Mary Elliott Lori Bue Credit Union Richard & Mari De Moya William Elman Hariette Bugbee Community One Federal James & Judy De Muth John Elmburg Daniel & Kathleen Bullis Credit Union Alfred & Bernice De Simone Dennis Elmer Jeannine Bultman Daniel & Rita Congdon Charles & Nancy Deadman David Ende & G. Wayne & Sandy Bunker John & Linda Conkright William DeCarlo & Kathleen Murphy-Ende Lillian Burdick Harry Conlon, Jr. Lorilyn Chamberlin Daniel & Rita Endres Luella Burgess Richard & Carolyn Connelly Christopher & Catherine Decker Terry Kahlert Eng Derick & Kim Burgher Jeffrey & Deborah Conner Thomas & Deborah Degnan James & Nancy Engelhart Jonathan Burke James & Zoe Connor Violet Dehring David & Zeena Engelke Kenneth Burns Conrad’s – Sentry, Inc. Mark & Marchia Delforge Leon Epstein Robert & Katherine Burris Brian & Suzan Cook Deluxe Corporation Foundation Paula Erato-Daggett James Burt Sr. Meg Cook Kay DeMinter Frances Erickson Edward & Lois Busby Robert & Bernice Cook, Jr. Steven & Veronica Dengel Phyllis Erickson Robert Bush John Copp Steven Denninger Estes Incorporated Robert & Carol Bush Mark & Kristine Corey Jane Dennis Scott & Susan Ethun Marvin & Susan Busta Harold & Dawn Corless Richard & Nancy DeRauf Mark Etzel & Regina Murphy Samuel & Debra Butler Charles & Blanche Cornwell Design Concepts, Inc. Eustice, Laffey, Sebrenek & Larry & Sheryl Butson Kathleen Corrigan Herbert & Mary Desnoyers Auby Golf Team Rodney & Susan Byers Patricia Cosgrove John & Susan Dickens Betty Evans William & Joan Byram Maribeth Cousin Ronald & Audrey Dierks Leacle & Dorothy Evans Martin & Lorraine Cadwallader L. Douglas & Carol Cowgill Donald Dierschke D.W. & Lila Evenson H. Kenneth & Janet Cain Trust Jack & Darlene Coyle Dale & Alice Doering David Ewanowski Jeffrey Calder Daniel & Patrice Coyne Ann Doherty Paul & Monica Fahrni California Credit Union League Rick & Karen Craig David & Nora Dohler Thomas & Eleanor Fairchild Marsha Callahan Calvin & Patricia Cramer Joseph & Joan Dolan Joel & Rhonda Fait Kent & Lynn Calloway Paula Craft Richard Dolan Audrey Falk Roy Campana & Kerry O’Donnell William & Judith Craig Dennis & Katherine Dorn Richard & Tina Faria Capital Brewery Company, Inc. Crane Reed Properties, LLC Peter & Mary Dottl Jeffrey & Terri Farley Miles & Barbara Capron Tyrone & Therese Cratic The Douglas Stewart Company, The Farmers State Bank of Gerald Cardo Mark Craven & Susan Goral Inc. Waupaca

37 $100 - $499 Donors Donald Gardner Gunderson Funeral Homes Robert Herman The Farres-Harrison Family Gary’s Piggly Wiggly, Inc. Joyce Gust Howard & Lillian Herriot Stuart Feen & Carol Sonnenschein Ramona Gasser Frank Guth Mark & Patricia Herrling William & Colleen Feist Russell & Bernadine Gasser Robert & Harriet Gysbers John Hess Sidney & Betty Felder John & Lisa Gast H. James & Sons, Inc. Robert & Beverly Hess Beverly Feltz James & Patricia Gaugert, Sr. James & Concetta Haag Mark & Robin Hessefort Douglas Feltz & Wai-Ming Lai Arne & Deloris Gausmann David Haase Jennifer Hicks Richard & Michelle Feltz Douglas & Charlene Gehrke Heidi Haeberli Jerome & Alice Hill Stewart Feltz Matthew Geiger Anthony Haen, Jr. Larry & Mary Hill John Fenton Grant & Nancy Gelhar Donald & Dana Hafeman Hill Electric, Inc. Edith Ferre Jacqueline Gemple Paul & Colleen Hagen Gregory & Audrey Hinger Charles & Nancy Fetter, Jr. Nicholas & Angela Genett Ramona Hagen Stephen & Susan Hird Kristin Ficks Peter & Susan George Shirley Hahn James & Barbara Hodder Patricia Fiedler Carl & Jane Geraldson David & Nancy Halford Richard & Sharon Hodge Ronald & Joanne Fiedler Alfred & Lorena Gerbitz John Hall David & Ann Hoffman Diane Field John & Geri Gerold Susan Hall Memorial Fund Kevin & Lorrie Hoffman Nancy Fielder James & Yvonne Gern George & Lois Hallam Tony Hoffmann Charles Filson Gregg & Lois Gerstmeyer Ruth Halverson Earl & Jean Holdorf Financial Center Credit Union James & Karen Geschke Scott & Cathy Hamilton Gene Holen Financial Kinetics Corp. Carl & Sheila Getto Terry & Alice Hampton Roumaine & Kathy Holland Kendall & Shirley Finger Sandra Ghandehari Richard & Laurie Handel Janet Hollatz Marvin & Roberta Fink Nicholas Giammaraco James Haney Lawrence Holley Patrick & Marilyn Finn Delores Gibson Linda Hanin Gary & Patricia Hollman Daniel & Carol Finnane Edward & Patricia Gibson Evelyn Hanisch David & Stephanie Honan Michael & Susan Finnane Mark & Margaret Giese Philip & Mary Hanratty Honold Family Trust Dorothy Finstad Thomas & Beth Giese Carlton & Mary Hansen Harold Hoops, Jr. Erik & Tabatha Finstad Joseph & Anne Gilles Wayne & Beverly Hansen Gregory & Lynne Hopkins Clarence Firari James & Kim Gilmore, Jr. Carryn Hanson James & Lucille Hornung First National Bank – Waupaca Robert Gilpatrick & Nancy Hilton David Hanson & Linda Bochert William & Carolyn Horton William & Elizabeth Fitzsimmons Glen Hills United Fund Philip & Mary Hanson William & Susan Hotz Janice Flannery Roy & Jean Glise Carolee Harari C. Vernon Howard Randy Flannery Allen & Martha Godding Christopher & Teri Haring Roy & Joanne Howard Wendy Fleer Mary Godfrey Charles & Prudence Harker Patricia Howell Fleet Wholesale Supply Co., Inc. Charles & Janice Goerg James & Donna Harrington Wendy Howell Fleetwind International David & Susan Goldberg Floyd & Joan Harris, Jr. Lisa Hrupka Allen & Mary Jo Fleming Susan Goldberg Turner & Mary Harshaw Larry & Mary Hudack Lester & Janet Floeter Debra Goldstein Ricardo & Elizabeth Haskins Kenneth Hueckstaedt & Joel Flottum Nerma Gollin Henry & Virginia Hart Joanne Rose-Hueckstaedt Florida Central Credit Union Theodore Goodfriend & John Hart, Jr. James & Leonette Huffer Kaj & Karen Foget Mary Lou Birkett Goodfriend Karl Harter & Christina Sheehan Ralph Huiras John & Karolyn Foley Goodwill Industries South Central Kim & Ann Harter Margaret Humleker Robert & Alvia Forsberg Wisconsin Christopher Harvath Erik Humlie Fort Knox Federal Credit Union Edna Gorder Philip & Barbara Harvey John & Melanie Humphrey John Foster Mark & Lorrita Gorman Nancy Haselhorst James & Karen Hunter David Foulkes Jack & Harriet Gorski Colleen Hasler Hunter Douglas Fox Cities Workforce Development Donald & Yvonne Gottschalk Hausmann-Johnson Insurance, Ernest & Betty Huntley - Job Center Robert & Katherine Gould Inc. Dean & Erva Hunzicker Fox & Fox, S.C. William & Virginia Grabel Hawaiian Tel Credit Union Thomas & Linda Hupf Michael Fraboni Carl & Nancy Graf Thomas & Diane Haye Paul & Teresa Hutson Francis Investment Counsel, LLC Kate Granick Heads Up Family Hair Care Lorel Huyett Memorial Herbert & Sylvia Frank Alden & Lucille Grant Heartland Credit Union Patricia Huyett Joyce Frank Dave & Barbara Grant Veronica Hearty Charles & Joyce Hyde June Franklin Grant Thornton, LLP John & Karen Hebbring Mary Hyland Kathy Frater Nikiann Gray-Tarantino H. Edward & Kristine Heckman Ideal Packaging Group, Inc. Joel Fraunfelder Greater El Paso Credit Union David Heim Insurance Agency John Idzikowski & Jane Stoltz Carol Fredrickson Greater Madison Convention & David & Charlene Hein Dale & Elinor Ihlenfeldt Marvin Freedman Visitor Bureau Eugene & Veryl Hein Iowa Credit Union League Jannan Freiburger Greater Warren Community Raymond & Barbara Heldt Indian Mound Middle School Freihoefer Family Gift Fund Federal Credit Union Hans & Marjorie Helland Oliver & Shirley Irgens Christopher Freitag & Victor & Jeanne Gregor Hanes & Pat Heller Marie Irrgang Ellen Kennedy Grey Horse Homesites, LLC Marsha Heller Allen & Kay Iskiwitz Family Fund William & Bonita Frels Douglas & Mary Griesbach Sandra Helton Alan & Claudine Jaeckel Roger Friede Sr. Michael Griffin Philip & Suzanne Henderson Larry & Deborah Jackson Edward Fritsch Griffith Laboratories USA, Inc. Philip & Elizabeth Hendrickson Scott Jackson Marilla Fuge John & Pamela Grinter James & Jane Henkel Robert & Carol Jacobson J. Stewart & Shane Fuller James Grisamore Robert & Marjorie Henkel Julie Jagemann Mary Fulwiler Paul & Dorothy Grogan Nancy Hennen Richard & Louise Jahnke Janet Fumuso David Groteluschen & Richard Hennen Carl & Sandra Jahns Leola Gabel Caitlin Stoltzmann Charles & Patricia Henrikson James River Equipment LLC Chad Gabert & Amy Stella Group Health Credit Union Isabelle Henrickson Eugene & Lori Jasper Mary Gage Carrie Guenther Jane Henry Leonard Jastroch Gall Plumbing, Inc. Grumman Butkus Associates, LTD. William & Bevain Henry George & Marilyn Jelich Edward & Donelda Gallagly David & Anne Gryczewski Robert Henseler Dale & Joan Jennerjohn Michael & Lisa Ganske Virginia Gschwind Heritage Family Federal Robert & Geraldine Jennings Richard Gumz Credit Union William & Jacqueline Jeske

38 Robert A. Jetmundsen Foundation Kimberly-Clark Corporation Patty Jewett Kin Ree Drywall Company, Inc. Johnson Bank – Racine Kinecta Federal Credit Union David & Mary Johnson Barbara King Dawn Johnson Howard King Trust Doris Johnson William & Virginia Kingzett Douglas & Mildred Johnson Anthony Kiorpes Edward & Rosie Johnson Jack & Nancy Kirby Gary & Lynn Johnson James & Donna Kirner Jeff & JaneMarie Johnson Robert Kirscht Joe & Catherine Johnson Keith & Catherine Kison Kenneth & Marilyn Johnson Randall & Patricia Kison Martin & Ruth Johnson David & Kathy Kistler Millard & Mary Johnson, III Kurt Klapperich & Van & Mary Johnson Mary Ann Steiner Willard Johnson Jeffrey & Mary Klees William & Charlotte Johnson Arthur & Georgia Kletti William & Jane Johnson Herbert Kliebard George & Carol Johnston Kenneth & Judith Kliebard Patricia Johnston Delbert Kliebenstein Lee & Rosemary Jones Mary Klinkner Ted Jones & Diane Felsted-Jones Patrick & Kathleen Klinkner Reid & Sue Jorgenson Ferdinand & Barbara Klobucar George Josheff Kevin & Jennifer Kloehn Pictured are Missy Livingston and her daughter Molly at the 2006 Jewel of Conrad & Susan Jostad Catherine Kluever an Evening, an annual event which raises awareness and support for the David & Jean Juedes Gregory & Bonnie Knechtges UW Gynecologic Oncology Program. Missy is creator of “Earrings of Love” William & Cynthia Kaether, Jr. Chester Kniech jewelry, which was featured in the event’s silent auction. G. Robert & Bonita Kaftan Bill Knilans Brad Kahl Kevin & Leah Knope Violet Landsness Hope Linton Kahler Law Offices Knothe & Bruce Architects, LLC Jill Lane Daryl & Marcia Lippincott Michelle Kahl-Parham Carol Knox Richard & Christine Lane Paul & Joann Lippitt Barbara Kaiser Suzanne Koch Daniel & Bernadette Lang William & Dorothy Little, Jr. Alan Kalker & Abigail Cantor Fred & Valerie Koehler Robert Lang & Lisa Lang-Riegel Efrat Livny Darlene Kallaus Mary Koenecke Hubert & Erika Langecker Lucille Locicero Donald & Christine Kalscheu Leonard & Janice Koenig Karen Langer Diane Loconte Joe & Rita Kaltenberg Wayne & Patricia Koessl Stanley Langer Helen Lodge Daniel & Mindy Kampen Herbert H. Kohl Charities, Inc. Teri Larkee Mavis Loescher Jonathan Kane Marty & Janis Komsa Cynthia Larkin Marilyn Lohman John Kaney Luvern Kopp Charles & Janet Larsen Neil & Lori Lonergan Merlin & Gerd Kanter Erick & Lucy Korbitz Jean Larsen Marc & Charlene Longino Carl & Patricia Karcher, Jr. Douglas & Judith Kornemann Kathleen Larson Vilja Lorenzsonn Joyce Karg Donald & Jean Koskinen Thomas & Arra Lasse Judy Lowell Kendall & Sharon Karpf Dorothy Kovacs Lathrop & Clark James & Marilyn Luck Virginia Karstaedt Ellen Kowalczyk Gary & Theresa Lau Gerhard & Sonja Luetschwager Ben & Lois Kaster C.E. & Patricia Kozarek Lynn & Mary Jane Laufenberg Carole Lukens Dean & Cynthia Kaster Grace Krajco William & Susan Laufenberg Gary Lukken Faisal & Gerda Kaud Margaret Kreblein Kenneth & Brenda Laughery Rolf & Ann Lulloff Jeannine Kaufman Jacquelyn Kriewaldt Christopher & Julie Laurent J. Robert & Mary Ann Lunda Todd & Lisa Kaull Edward Krinsky Robert & Marilyn Laurion John Lunenschloss Marcella Kautza Shirley & Stanley Kritzik Mary-Lynn Lavine James & Christine Lutz Arthur & Maura Keene Philanthropic Fund Ben & Joan Lawhorn Jane Lyons Frederick Kelcz & Sheryl Popuch Neal & Eva Kroll Donald & Mary Layden, Jr. Jason Maas Steven & Angeliki Kellner Frank & Christine Kromenaker Robert Lazarz Dennis & Valerie Mack Todd & Tracy Kellner Dolores Krueger Judith Leavitt Shirlene Mack George Kelly Otto & Johanna Krueger Misha & Cari Lee Kay Mackesey John & Lee Kelly Caroline Kubicki Jack & Georgia Leech Rae Madar Richard & Alice Kelly Jerry Kuehn Kimberly Lehman Madison Gas & Electric Company Mark Kelty & Lisa Moore-Kelty David & Marie Kuemmel Tom & Judy Lehman Madison Motorcycle Club Thomas & Ruth Kent Daniel Kuesis Nina Leib Madison Symphony David & Mary Jean Kennedy Joseph & Miriam Kuhn Marie Leithauser Orchestra, Inc. Martin & Mary Ellen Kennedy Anthony Kujawa & Roy Lembcke Madison Top Company Kern Schools Federal Credit Union Susan Eldred-Kujawa Frank & Harriet Lenhart Ernest & Helen Madsen James & Jeanne Kerr Greg & Marianne Kulka Miguel Leon-Benito & Kevin Magee Pamela Kerr J. Raymond & Felicia Kuna Julie Yearling Robert Maichow Violet Kersting Steven & Deborah Kurkiewicz Dorothy Lewis Harvey Malofsky Daniel & Ann Kettler Isidore Kwaterski Nanette Lewis William & Katherine Malkasian Roland & Shirley Keuler Robert La Mar Peter & Ann Lewis Michael & Diane Maloney Keys Federal Credit Union Jon La Paz Robert & Ruth Lezotte Roderick & Wilma Mann Thotsaphone & Ladies Auxiliary of Madison Elks, Kip & Dianna Libman Bruce & Cheryl Manthey Chanthila Khampane #410 Michael & Elizabeth Lichtenberger Fred & Faye Marcus Julie Kidd Susan Laemmrich James Lichty & Howard & Marci Margolis Daniel & Nancy Kiernan Bradley & Kathleen Lake Jacqueline Allen Lichty Mark Markel & Lisa Steinkamp John Kierstyn James & Shirley Lake James & Margaret Liebig William & Elisabeth Marling Kil-O-Watt Klub Peter & Patricia Lamkins Erna Liebzeit Peter & Rebecca Marnocha Henry Kimberly, Jr. Katherine Lamont Anders Linner & Dorothy Johnson-Linner

39 Nina O’Kelley Beatrice Occhietti Paul & Barbara Odland Ohio Credit Union League Ohio Education Credit Union Judd & Tracy Olson Greg & Debra Onken Open Pantry Food Marts of WI Scott & Joleen Opsal Optimist International Foundation Optiz Management Inc. No. 2 Floyd & Sharon Organ Peter & Artie Orlik Jean Orvold Lettie Osborne Thomas & Romana Ostrowski William Ostrowsky Cancer Center staff and volunteers manned their own water station at the 2006 Mad City Marathon in support Otsego Charity Funds of runners Jody Schwerdtfeger Rough and Darren Fortney. Jody ran in memory of her mother and Darren is a Harold Ottenstein cancer survivor himself. Both ran to raise money for the UWCCC. Lois Otto Joseph & Mary Ousley $100 - $499 Donors Janet Mertz Douglas & Shirley Mullen Outokumpa Copper Valleycast, Inc. Kathryn Marotz John & Joellyn Merz Municipal Credit Union Gary Overboe Marsh & McLennan Companies, Karl & Jami Merz Donald & Joan Murphy Richard & Judy Owens Inc. Gary & Sally Messner M. Patrick Murphy Mark & Louise Packard Marshall & Ilsley Bank – Madison Kevin & Tina Metcalfe Susan Murphy Elizabeth Paddock Charles & Cynthia Marshall Irmgard Metz Tele Murphy Rick Page Charles Martin & Maxine Meyer Gene & Beatrice Musolf Thomas & Elaine Pagedas Kathryn Schubert Paul & Elise Meyer Jon & Patricia Myers Daniel & Janice Pagel Frank & Marisa Martire Leonard & Beverly Meyers Walter & Nancy Naab Paul Pagenkopf John & Ruth Marty Jeffery Michalcyzk Andrew Naber & Dorie Miller Norman & Valeria Pakes Dennis & Sara Marz Robert & Judith Mickelson Steven & Irene Nack Thomas Palmtag Massey Employee Benefit Plans Wesley & Berniece Mickelson Nakoma Golf Club, Inc. Harry & Virginia Papcke Patricia Mathis Wayne & Virginia Micksch National Exchange Bank & Trust James & Sandra Pape Roderick Matthews & Marie Sieker Donald Miller Erich & Cheryl Natzke Milo & Deborah Parker Gerald & Barbara Maxwell Duane & Jane Miller The Neckerman Agency Michael & Janis Parkinson Mays Insurance Agency, Inc. Gary Miller Michael & Rosemary Neider Jack & Cheryl Parrino John & Joyce McAnelly Jerome & Penalee Miller John & Shirley Nelesen Tara Passow Edward & Marilyn McArdle Richard & June Miller Steven Nelesen Dennis & Cathy Pattee Paul & Linda McBride Robert & Gertrude Miller Randy Nell Robert & Kathleen Paul Martha McCann & Robert & Jill Miller Richard & Judy Nell Richard & Louanne Pauley Theresa Harvath Robert & Nancy Miller Douglas & Lynn Nelson Richard & Rachel Paull Ellen McCarville William & Iris Miller Jess & Darlene Nelson Ratko & Darlene Pavlovic Joan McCaughn William & Lorraine Miller Orville & Selma Nelson Ann Peckham Timothy McConville & Gerard & Lorraine Millette Robert Nelson Maxine Peckham Jan Eymann-McConville Marilyn Milligan William & Linda Nelson Karen Pederson Richard & Janice McCormick Chad & Donna Milne Arthur Nesbitt Peter Peil Marilyn McCubbin Greg Milward Thomas & Ruth Nesbitt Ken & Susan Pelatzke John McDermott Gigi Mitchell Lyle & Lois Nestingen Jonathan Pellegrin Barbara McDonald James & Linda Mitchell William & Nancy Nettleton Donald Penberthy Ronald & Debbie McFall James & Rita Mitchell Craig & Susie Nevins Alan Penn Verda McFarlane Kevin & Leslie Mitchell Elizabeth Newell Pennsylvania Credit Union Michael & Judith McGinley Mary Ann Mitchell New York Life Insurance Group Association Patricia McGovern Robert & Karin Moe Charles & Rachel Nichols Robert & Judith Penrod Patrick & Angele McGrady Mehrzad & Bonnie Mohammadi Harold Nichols Pentagon Federal Credit Union McGrath Associates, Inc. Arnold & Aletha Mohlman John & Lori Nolan Bruce Perchik & Walter & Helen McGregor Jean Mohrhauser Mark Nolen Barbara Nichols-Perchik James McGuire Thomas & Nancy Mohs David & Susan Norby H.J. Pertzborn Plumbing & Margaret McGuire David & Jeann Molliconi Dale & Katherine Nordeen Fire Protection Lisa McIntosh Darlene Momberg Richard & Barbara Norene Gerald & Carol Petersen Richard & Jean McKenzie Monona Community Festival James & Harriette Norman William & Diane Petersen Jennifer McKersie Committee, Inc. Tom Norris JoAnn Peterson Maxine McKilligin Tull Monsees North Central Trust Company Georgia Petrie Florence McNett Charles Montgomery Northeast Council CUES John & Susan Petterle Marlie McRoberts Phillip & Ruth Montgomery Northern Illinois Corvette Club Phi Beta Cabin Quilter’s Sorority Howard & Nancy Mead Darin Moody Norwood Custom Homes, Inc. Delores Phillips Diane Medcalf Alexandra Moore Tom & Gail Novacheck J. Michael & Patricia Phillips Karena Meehan Guy & Judith Moore Marilyn Novinska Hans & Susan Pigorsch Hildegard Mefford Lee & Mari Lynn Moritz William & Susan Nusbaum Dennis & Ariane Pink Brian Meier & Michael & Judy Morman Armin & Rita Nyffeler LuAnn Pink-Kratochwill Mekel Wiederholt Meier John Morris The Nygren Living Trust Richard Pire Lloyd & Frances Meier Dottie Moseley Paul & Beth Ann Nylander Arthur & Delores Pitas Larry & Renee Meiller MPB Builders, Inc. James & Monica O’Brien Cecil & Katheren Pittack Marvin & Frances Mengeling Eugene & Janet Mueller Mary O’Dell Stephen & Lesa Pitts Philip & Marcia Merrick Brian Mullane Timothy O’Keefe Placon Corporation

40 John & Maryanne Plant Stanley & Marla Richter Donald & Narcisa Schmidt Mark & Diane Silverberg Steven & Sue Plater Gordon & Susan Ridley Krista Schmidt Deb Simon JoAnn Six Plesko Stewart & Donna Rieckman Paul & Cecilia Schmidt, Jr. Francis & Rosemary Simonis Pamela Ploetz Gerald & Armella Ring Paul & Jane Schmidt Mary Simonson Charles Plotz Lee & Susan Riordan Roger & Jolene Schnabel Carl Sinderbrand & Maryann Sumi Thomas & Janet Plumb Lila Ritchie Glenn & Mary Schnadt Robert & Glenda Singiser Wilfred & Frances Polzer Peter & Carrie Ritz Donald & Patricia Schneider Skaalen Sunset Homes, Inc. Lori Polzin RML Enterprises, Inc. Tommye Schneider Ellen Skaar Point West Credit Union David & Lynne Roark Dolly Schoenberg Darold & Jean Skelton Arthur & Elizabeth Pope Anne Roberts Schoep’s Ice Cream Co., Inc. Richard Skorupan & C. Renee Poppe Catherine Robertson Cynthia Schoepp Carol McNeill Skorupan Carl Porter Joan Robinson Jeanne Schoepp Kathleen Skrake Dennis Porter Marla Robinson James & Shirley Schommer Harold & Verna Skrenes Mary Poser Theodore Robinson-Myers David School Eugene & Kathryn Skroch Nancy Powers Ellen Roche School Employees Credit Union Barbara Slack Prairieview Feeds, Inc. Rocky Mountain CUES Robert & Mary Lynn Schraufnagel Helen Slavens Phillip & Alison Prange Scott & Georgia Roeming James & Nancy Schroeder Dorothy Sledge Richard Preissel Beatrix Roesler Loren & Mary Schroeder L. Joseph & Marlys Sloup Priority One Credit Union John & Jann Roethe Lawrence & Georgina Schrock Blake & Sheri Smith Steve Proefrock & Terry Gall Neal Rogers Louis & Elizabeth Schueller Charles & Barbara Smith Alan Propst George & Patience Roggensack James & Jean Schuenke Clayton & Mary Jane Smith Charles Pruett Rolland & Margaret Roggensack Ronald & Barbara Schuler Craig Smith & Merritt Clapp-Smith Otto & Barbara Puls Eileen Rolph Estate Timothy & Michelle Schuler George & Sara Smith Richard & Marlene Pump Russell & Patricia Rose Douglas & Ruth Schultz Gordon & Shirley Smith Marvin & Jean Pupeter Tyler Ross George & Dorothy Schultz Lanny & Margaret Smith Barb Quamme Edwin & Bernice Rossini Julie Schultz Lori Smith J. Douglas & Karen Quick Richard & Lois Rossmiller Robert Schulz Michael & Debra Smith James & Lisa Quick Richard & Joann Rost Winton & Ruth Schumaker Fund Norma Smith Raymond & Carolyn Quick Sonia Sue Rotar Larry & Constance Schuster Robert & Betty Smith Tim & Edda Quigley Barbara Roth Steven & Wende Schuster William & Elizabeth Smith, Sr. Quivey’s Grove, Inc. Ingrid Rothe Schwab Fund for Charitable Giving Smith & Gesteland, CPA William & Natalie Raaths Stephen & Kathleen Rothering Thomas Schwanz Charles & Jean Smoots Richard & Laurita Radtke Jeffrey Rothstein Steven & Doris Schwartz Ann Soderstrom Ryan Radtke & Kathy Gore Jerry & Gloria Rotramel Owen & Nancy Schwerdtfeger Glenn & Carol Solheim A. Scott Radwill Royal & Muriel Rotter Ronald & Adele Schwoegler Thomas Solheim Robert & Elizabeth Ragan Anne Rough Allan & Barbara Scidmore Albert & Joyce Solochek John & Betty Rahm Donald & Linda Rough Score Chapter, #145 Steven Soma Jeff & Karen Raizen Roundhouse Marketing & Betty Scott Catherine Sommer James & Michelle Rameker Promotions, Inc. Robert & Lana Scott Paul & Sherie Sondel Charles & Lucille Ramshaw Kathryn Rouse Seaside Helicopters, Inc. Shiyu Song Lawrence & Richard & Doris Rudisill Seattle Metropolitan Credit Union Jack & Helen Sorge Barbara Rapisarda, Sr. Frederick & Patricia Ruegsegger Secureworks, Inc. Ronald & Christine Sorkness Jean Rappold Gregory & Karen Ruffner James & Cynthia See Jerry & Jeanan Southwood Harold & Thelma Rasmussen Dean Rugotska Mary See Walter Southwood & Carleen Wild James & Elizabeth Rasmussen Patrick & Alvina Runde Barbara Seifriz Harry & Bonnie Spiegelberg Roger & Nancy Rathke Robert & Laurel Runte Roger & Shannon Seip Rick Spiel Jeannine Raufman Shirley Ruosch Larry & Sue Seitz Patricia Sporer Michael Redmond & Irene Temple Jack & Betty Ryan Sekelsky Family Fund Lilah Sprecher John & Jean Reeb Janet Ryan John & Kristine Selk Springs Harbor Auto Clinic, Inc. George & Susan Reed Michael & Judith Ryan Bruce & Amy Selkirk Springvale Charities Fund Todd Reed & Carol Humenick Nancy Ryan Timothy & Lisa Semmann Spurgeon Vineyards & Winery LLC Don & Carol Reeder Alfred Sacha Ng Liang Seng Ronald & Mary Staben Mary Reese Paul & Alva Sachs Roger & Margery Senn Thomas Stafford Robert Reese R. Thomas & Katherine Saether Jerrald & Donna Sessions Stafford Rosenbaum, LLP Jim Refsguard Larry Saevre Paul & Beth Ann Sever Sally Stanek Timothy Reilley & Janet Nelson Peter Sahagian Walter & Nancy Sexton, III Thomas & Leona Stanek Frederic Reimer Barbara Sainsbury Luella Shackelford Thomas Stanton Elizabeth Reinartz Todd Sainsbury Diane Shadel The Stark Company Keith & Cynthia Reissaus Leo & Martha Sakowsky Midge Perlman Shafton Bart Starr Lois Rens Glenn & Lucille Salter Philanthropic Fund Raymond & Ellen Stasieluk Jennifer Renville Jose Sanchez & Wendy Harbath Doris Shain Sandra Staves Janet Reschke Daniel Sapiro & Suzanne LaFleur James & Jean Sharer STCU Credit Union Research Products Corporation Shirley Sather David Shaw & Janice Becker Henry & Kathie Steare Diane Resek James & Barbara Schaefer Jeremy & Ann Shea Joyce Steensrud Jill Reuss Wilbur Schaefer Robert & Rosemary Shea Robert & Marsha Steffen Phillip & Joyce Reuter Marc & Carol Schatz Gregg & Barbara Shimanski Charlotte Stein Margaret Rewald William & Rolliana Scheckler Leonard & Bernadine Shimko Jane Stein James & Barbara Rewey Janice Schefelker Neil & Jacqueline Shively Richard Stein Ben & Karen Reynolds Russell & Chari Schieber Ray & Carol Shubgert Robert & Beverly Stein Diane Rezagholi Earl & Adeline Schiefelbein Michael & Maria Shulba Marc & Deanna Steiner John & Shari Rice Schierl Companies Peter & Rella Shulla Gary & V. Terri Steinhauer Richard Rice Jean Schilling Marvin & Judith Siegert Robert & Rochelle Steininger Sara Richards Robert & Marilyn Schilling Steven & Barbara Siehr Kristin Stephens Paul Richert Fred Schlater Michael Siemion Charles & Sharon Stern Gerald & Lorraine Richter Ernst & Faith Schlieter Donald & Joyce Sikora Hattie Stevens

41 $100 - $499 Donors Paul & Renee Thums Von Stiehl Winery George & Helen Wilding Stevens Construction Corp. Kenneth Thygerson W.W. Grainger, Inc. Thomas & Mary Wilding Douglas Stewart & Tamara Harvey Timothy Tierney Joyce Waedow Arline Wileman Jessica Stewart Matt Tiller & Andrea Engebretson Dane & Susan Wagner Joyce Wilhelms Marjorie Stewart C. John & Barbara Tolch J.A. Wagner Construction, Inc. Mark Wilke Walter Stewart & Jill Tolman Robert & Edna Wagner Allen & Judy Wilkins Pamela Hanson-Stewart Jill Tomalin Stanley & Mary Wagner Gerald & Judith Wille Margaret Stiles Ray & Marion Tomlinson Candace Walker Anna Maria Williams Phil Stoddard Victoria Topp Dale & Nancy Walker Kirsten Williams Thomas & LaVonne Stodola Thomas & Beverly Tormey, III Donald & Nancy Wallace Neil Williams & Jane Mendelsohn Gregg Stoffel Tom & Dianne Totten Wal-Mart Store - Baraboo Ruth Williams James & Ellen Stone John Touchett Florence Walsdorf William Williamson Muriel Stoneman Artha Towell Gloria Walsh Mary Wilson Gerald & Jacquelyn Stordal William & Elizabeth Towell Leo & Carole Walsh Paul & Terri Wilson Michael & Kendra Story Towers Perrin Patrick Walsh Jane Wimann Carmen & Katie Stout Town of Columbus Charities Ted & Ruby Walton John Wink & Jennifer Olk Elaine Strassburg John & Maria Townsend Tom & Kelly Walzer Clark Winn Anthony & Shirley Stratil Stanley & B. Ann Trail Edward & Marie Wanke Wisconsin Alumni Assoc. Richard & Susan Straus Trinity Staffing Group Terry & Mary Warfield Alumni House David & Sandy Street Robert & Norma Trojan Peter Waterman Wisconsin Capital Management, John & Patricia Streur Betty Trombetta Ron & Diana Waterman LLC Ida Stricker Walter & Viola Trzeciak Kenneth & Beverly Watson Wisconsin Distributors LP Gregory & Lea Stroncek Gary & Janet Tupy Lyle & Carol Watson Wisconsin Insurance Alliance Seward & Margaret Stroud Jerald & Kendra Tutsch James & Julie Watt Wisconsin Reinsurance Corp. Craig Struble John & Judy Twesme Lester & Karen Watters Wisconsin Vintners Association Larry & Susan Stuckman Twin City Die Castings Company Waupaca Pallet, Inc. Wisconsin Winery Association Martin & Virginia Stuller Wilna Tygum John & Susan Waxler, Jr. Jane Wise Charles & Diane Stumpf Leonard Tysver Weakie Credit Union Steve & Alice Wise James & Sheerin Sturm Jon & Susan Udell Deanna Webb Elmer Wisnefsky Patrick & Kathryn Sullivan David & Judy Ulery Chris Weber Frank & Grace Witko Sun Prairie Lions Club John & Gail Underwood Creighton Weber Christine Wittenberg Suncoast Schools Federal Uniek Robert & Anne Weber Barbara Woessner Credit Union United Fund of Marion Susan Weber Lynn Wolf Frederick & Mary Sundby United Nations Federal William & Karen Weber Richard Wolf Barbara Suran Credit Union Weber Marketing Group Ronald & Barbara Wolfe Mary Sutherland United San Antonio Community Robert & Shirley Wegenke Gary Wollenzien Robert Swanson Federal Credit Union Albert Wehde Bruce & Linda Wollpert Russell & Ruth Swanson Unity Hospice Frederick & Mary Wehmeyer Joseph & Susan Wolters John & Kathy Swenson James & Linda Upchurch William & Barbara Weidanz Peter & Karen Wood Kenneth & Irene Sweo USA Credit Union Dorothy Weigle Lance & Teresa Woods Swiss Colony, Inc. Jonathan Uttech Sybil Weinstein Woodstream Philip & Penelope Symes UW Health Dept. of Scott & Tina Weis Harold & Charlotte Woolf T.W.A. Clipped Wings International Gastroenterology Ruth Weisensel George & Marjorie Wordingham Semand Trsae Tan Juri Valdov Frank Weiss John & Judith Worm Ralph & Norma Tandowsky, Jr. Margaret Van Boven James & Ann Weiss Bill & Edith Wright Travis & Vicki Tank Harry Van Camp Robert & Joyce Weiss Harry & Joan Wright Harold & Ethel Tarkow Robert & Loraine Van Eerden Philanthropic Fund Paul & Marilyn Wright Dean & Shirley Taylor Judith Van Kirk Steven & Kathleen Weller William & Mardelle Wuerger Rayla Temin Michael & Karen Van Overberghe Wells Fargo Home Mortgage Erwin Wunn Tennessee Credit Union Ron Van Rossum Harvey & Bonita Wendel Michael & Nancy Yaffe Dean & Michele Teofilo Peter & Mary Van Sistine Darin Wendt Robert & Nancy Yahr Robert & Marilyn Teper Garrett & Laura Van Tassel Michael & Terry Wermuth H. Edwin Young Fred & Betty Terbilcox Norton & Tribba Vande Poele, Jr. Betty Werner Mark & Malka Young Marilyn Terwilliger Jeane Vanderveer John Werner James & Nancy Youngerman Jerry & Carol Tessen Philip Vangsnes Michael Werthmann Jane Zekoff Anthony & Marlayne Testolin Vantage Credit Union Marie Wescott Warren & Deborah Zelenak Texas Instruments Foundation Joseph & Mary Varese Daniel & Joyce Wessley Rose Zerwick Gerald & Priscilla Thain Neil & Eileen Vassau Jay & Rosemary West Alford & Susan Zick, Jr. Earl & Alice Thayer Betty Vaughn West Madison Little League Helen Ziegler Jane Thieleke David & Nancy Veenedaal James & Joan Westergard Mary Ziegler Thomas & Ruth Thielke Donald Venden Brett & Megan Westrum Patricia Ziegler J. Leroy & Mary Thilly Venture Investors, LLC Marsha Wetmore Sylvester & Margie Ziegler Barbara Thompson Lee Vermeulen Jr. & Jill Kolesar Ivan & Joan White Richard Ziemann Beth Thompson Vermont Federal Credit Union White Birch Printing, Inc. Harriet Ziemer John Thompson & Brian & Mary Vick Whitmire Micro-Gen Research Daniel & Jill Zifkin Karen Butler-Thompson Steven & Donna Villand Labs, Inc. H. William Zilisch Marion Thompson Stanley Vinge Whyte Hirschboeck Dudek SC Frank & Diane Zillner Marvin & Dolores Thompson Albert Vinje Nicole Wieck Dorothy Zima Don & Cynthia Thomsen Miriam Vinje Douglas & Rebecca Wieczorek David & Jill Zimbal Lester & Sandy Thomsen Virchow, Krause & Company Peggy Wiederholt Marian Zimbric Dennis & Joan Thomson Alan Vogt & Patricia Clark Neil Wienke Donald & Cynthia Zimmerman Gregory & Julie Thorn Dorcas Volk Andrew & Melinda Wilcox Allan & Mary Zins Jack & Elisabeth Thorpe Verne & Laverne Vollrath June Wild Helen Zippel Thrivent Financial for Lutherans Richard & MaryEllen Von Haden Wild Rose Lioness Club Alvin & Donna Ziven Ronald & Barbara Von Haden Wild Rose ‘One Fund’ Drive Hassan Zoroufy

42 Gary & Charlotte Zuerner Wesley & Beverly Zulty Gene & Amy Zumwalt Roger & Carla Zwickey Kathleen Zylka

We have made every effort to list all $100 and above gifts received between July 1, 2005 through June 30, 2006. If your gift was inadvertently omitted, or if there is an error on our part, we apologize. If you have any questions, please call (608) 263-1677.

In-Kind Contributions Pictured above are Winnecone Elementary School staff who, for the past three years, have held a “Denim Day” Badger Bowl fundraiser for breast cancer research. Just over $2,000 has been raised in total. Badger Jim Beam Club Bandung Baymont Inn & Suites Marriott Madison West WISC TV-3 Nancy Boelter Best Buy Company, Inc. Maple Bluff Country Club Bag Wisconsin Cancer Council Larry Boh Best Western West Towne Mall Room Staff Wisconsin Women’s Health Jane Bohn Pat & Andy Biba Charles Martin & Foundation Mary Bond Bishops Bay Country Club Kathryn Schubert Frieda Borenstein Blue Marlin Restaurant Richard & Jean McKenzie In Memory Of Jean Bowers Blue Moon Bar & Grill Mediterranean Café Memorial gifts are given in Richard Brachman, Sr. BR Diamond Suite Benstan Meils memory of a loved one who is Thomas Brenner Café Continental Metcalfe Sentry Foods deceased. A minimum gift of Helen Brieger Capital City Coins & Jewelry Michael’s Frozen Custard $100 has been made in memory Gloria Bright Capitol Chophouse Mickie’s Dairy Bar of the individuals listed from Janet Brown Chalmers Jewelers Milwaukee Brewers Baseball Club July 1, 2005 to June 30, 2006. Mildred Brus Cherokee Country Club The Milwaukee Bucks Mary Linthicum Bryan Choose Hope, Inc. Warren Misiewicz Maureen Adamski Duncan Bryant Circle of Hope MMI Mary Ann Allen Robert Bue Sheri Cosgrove Timothy Muldowney & Kenneth Allison Connie Bugbee Dan & Patrice Coyne Jacquelyn Hank Shirley Amberg Dale Bultman Crandall’s Carryout & Catering Noodles & Company Naomi Ammerman Nancy Burdick Culvers of Middleton Olive Garden Aaron Anchor Walter Burkheimer Damon’s Madison East Open Circle Healing Arts Ellie Anderson Betty Bush Dairy Queen – University Ave. The Original Pancake House Jay Anderson Joan Buss Diny’s Jewelers Orpheum Theatre Joseph Anderson Lew Butler Douglas Stewart Company Overture Center for the Arts Terry Anderson Glenn Butters The Fanny Garver Gallery Panera Bread - Fitchburg Claire Apfelbach Thomas Callahan Fitzgerald’s of Middleton Panera Bread - Madison Eileen Arnold William Campion Francie’s Casual Café & Lounge Pat O’Malley’s Jet Room Melissa Arnold Alan Caplan Cecil & Sheila Gillingham Pizza Hut of Southern Wisconsin, Dale Arneson Dr. Paul P. Carbone Glass Nickel Pizza Co. Inc. Nancy Babler Patricia Cardo Greenbush Bar The Prime Quarter Steak House Barbara Babler-Vollrath Myrna Carlson Dale Hagen Quivey’s Grove Barbara Bachhuber Sally Carpenter Kari Hankins Rejuvenation Spa Jeffrey Badtke Sandra Carroll Harbor Athletic Club Romance Jewelers Marcus Bagniefski Elizabeth Carter Hawks Landing Golf Club Ray & Carolyn Schirmer Richard Bailey Arthur & Sally Cassady Johnny Hellwig Kirk Schnitker Sharon Bales Peter Cates Richard & Marcella Herfel Schwoegler Park Towne Lanes Mary Bargren Carol Keck Christenson Hilton Madison Monona Terrace Select Inn B. Kent Bauman Seymour Clarke Husnus Smoky Jon’s #1 BBQ Elizabeth Baxter Alfred Cleland Just the Two of Us Smoky’s Club Phyllis Beck Charles Cline Kitchen Hearth Soulful Creations by Susan Fred Becker Cynthia Clum Anne Klaprat The Soap Opera George Becker Frieda Cohn Jason Klein Star Cinema Cathie Beckwith Mary Colvin The Klinic State Bar & Grill Bunny Finnegan Behling Susan Connell-Magee Kneaded Relief State Street Brats Merlyn Behr Judy Copp The Kollege Klub Ten Pin Alley Donald Benn Barbara Corrigan Little Luxuries Wayne & Darlene Turney Terri Benzmiller Gene Craft Pete & Aline Lundstrom UW Athletic Department Ruth Berge Marlys Cramer Roy & Charline Lundstrom UW Health Center for Patricia Berk Elvin Crispell The Madison Concourse Hotel Integrative Medicine Lynn Berman Marion Cuccia Madison Mallards UW Health Marketing & Harold Bewick Joan Cullen Madison Monona Terrace Public Affairs Tyler Birenbaum Marianne Cullen Madison Repertory Theatre UW Hospital & Clinics Howard Blauert Thomas Cunningham Madison Top Company UW School of Medicine & Anna Blum James Daubenspeck Maple Bluff Country Club Public Health Carole Bochis Joan Davenport Marigold Kitchen Watches by Wackerle Grace Boelk Susan Davis William Thomas Designs

43 Joyce Kliebenstein Mary Meeuwsen LaVaier Kliefoth Larry Meiners Kevin Klingbeil V. Thomas Metcalfe Roy Klink Barbara Meyer Henry Klinkner Eugene Meyer Larry Kluever Gary Michaels Frederic Knilans Arletta Miller Donald Knox Colleen Miller Robert & Maryalice Rosemary Miller Koehne James Mitchell Marguerite Kopp Paul Mittelstaedt Nora Korwitz Sharon Moberg Jean Koskinen Salvatore Mobile Mike Kosmak Howard & Rosemary LaVerne Kozminski Moebius John Kraft James Montgomery Wilfred Krajco Matthew Morrell Anne Kraus Mary Mucks Lucian Krawczyk Lloyd Mueller Members of the statewide VFW Ladies Auxiliary present a $16,560 check to Ashley Kitty Kreft Robert Mueller McGuire of the Cancer Center. This donation represents proceeds from multiple Elmo Kriewaldt Lisa Mullen fundraisers held throughout the year. Eleanor Krizenesky Marjorie Musolf Karin Kromenaker Shirley Musser In Memory Of Marc Gempler Elizabeth Hillhouse Mark Krone Frank Muth Alfons Dehring Eugenia Gerken Charles Hobbs Henry Kubicki Robert Najem Kenneth DeVries Doris Gerndt Anton Holewinski Karen Kuehn Arthur Nelson Freda Diefenthaler Reza Ghandehari Diane Hollatz Yvonne Kuhn Carol Nelson Claryce Dierschke Stanley Gibson Mary Holley Susan Kuzan Debbie Nettum Anthony DiSalvo Rose Gladbach Daniel Honold Robert Laemmrich Kent Newell Carolyn Dodge William Goldberg Elizabeth Hopkins Barbara Lakaie Jeanette Nichols Jean Dolan Sherry Goldstein Paul Horbinski Douglas Lamont John Norman Deborah Donaldson David Gorski Louise Hotz Robert Langer Robert Novinska Alma Doty Judith Gothard Marjorie Howard Ellen Lapinski O. Richard Nutter Gladys Drake Janet Gould Brian Howell Carol Larkee Lois O’Byrne Mary Drecktrah Jack Gracey Cheryl Hoyt James Larson Mary Ellen O’Keefe Marla Drieling William Granger Beth Hubbard Gerri Lavine Colleen O’Meara-Schams Jean Duncanson Wesley Grant Mary Huber Donna Lawhorn Victoria Oakes Ralph Dykstra Frederick Graves Peter Humleker, III Mr. & Mrs. Ira Lecy Anthony Occhietti Tim Eagle Ruth Green Lorel Huyett Ronald Leib Elnore Okruhlica Loren Eckert Patricia Griesbach Donald Janke David Leichtfuss Thomas Olk Jerry Ehrmeyer John Grkavac Frantie Jessie Rita Lenhart Alice Olson Ray Eiben Valentina Grkavac Linda Jett Judi Lepofsky Sue Oppenheim Clifford Erickson Clifford Gust Alice Johnson Marie Flanagan Leyrer F. Harwood & Lucile Robert Erickson Peggy Haen Lila Johnson Merlin Liebzeit Orbison Richard Evans Dana Hafeman Linda Aplas Johnson Martha Lippitt Ernest Osborne Robert Evensen Jim Haggard Mary Johnson Joe Locicero Ruth Ottenstein Frank & Elodee Failla David Hague Willard Johnson Edward LoConte Darwin Otto Marjorie Fait Cletus Hahn Ruby Jonas George Loescher Donna Overboe Bruce Falk William Halfman Michael Jordan Ginger Long Yvonne Ozzello Robert Faltersack Susan Hall Matilda Joseph Edgar Lorenzsonn Mary Padgham Mary Fass Helen Halverson Martha Josheff Kirt Ludwig Floyd Parpart Janice Fatura Marsha Hamilton Gustave Juhlin, Jr. Alice Lukken Robin Paschal Dorothy Feeley Dexter Haney Dorothy Kahlert Nathaniel Lynch Charlene Paul Thora Feist Eugene & Sue Hanmer Maureen Kalinowski Gwendolyn Madsen Janet Pavlini Carol Feltz Alberta Harr Frederick Karg Richard & Marie Malchow L. Clark Peckham Valmai Fenster Peter Hasler Kenneth Karlen Bernice Maggio Bruce Pederson Robert Fettig Lenna Hathaway Erich Kasper Blanche Margolis Carolyn Peterson Marlene Fey Todd Haukom Cynthia Kaster Michael Marinelle Eleanor Pettibone Michael Fink Robert Havens Arthur Kautza Melva Marling Ellen Phillips Jim Foley Melanie Heald John Kayser John Marotz Marla Phillips M. Sandra Foster Joseph Heim William Keck John Marty Judi Pieper Robert Fox Armond & Eleanor Heimerl Rachel Kelcz Dana Maselter Neil Pier William Fox Sandra Hein M.P. & Ivy Kelly Melvin May Gary Pike James Frank Norman A. Heiser Christopher Kettner Michael McCannon Robert Pike Martin Freedman Patricia Helland Brad Kerr Peter McCarville Clement Pink James Frehner Vernon Hellenbrand Jo Kerr Barbara McCullough Roger Plantico Eldon Freiburger Ellen Jane Henderson William Ketchum Robert McDermid Joseph Plotkin Don Fugere G. Robert Henderson Thomas Kieffer Esther McFarlane Rose Plotz Stanley Fulwiler Mary Ann Henning Judith Kierstyn Robert McFarlane Thomas Polhman Walter Fumuso Donald Henrickson Sally Kind Mac McGuire Rose Pruett Joseph Gambino Betty Henry Ronald King Christine McHugh Roger Quamme Robert Gard Jean Henseler Mary Kirkpatrick Alvina McIntyre John Quick, III Robert Gasser Raymond Hepp Leila Kittleson George McKilligin Clarence Rabas Gerald Gausmann Eileen Herman Ann Stroh Klebermass Max McQuade Dannielle Radtke LeRoy Heuler Bernice Kliebard John Meehan Albert Ravid

44 Rose Ravid Lloyd Stein Eric Wolfe Patricia Fox Lindsay Nolan Kathleen Reader John Stewart Robert Wollersheim Jared Fredrickson North Bristol Sportsman Deborah Reese Frank Stiles William Wollin James Gilmore Club Members Dana Reeves Matt Stivarius Christopher Wood Mary Grogan Katie Paul Patsy Reif Helen Stockland Donna Wood Mary Ann Hager Gay Pelock Roger Resek Marcy Stoddard Renate Wunn Edward & Nancy Hanson Cathy Plate Dory Resneck Susan Stoddard John Wyatt Paul & Sarah Harari Robert & Gale Radtke Joyce Reynolds John Stoltz Susan Yost Chris & Teri Haring Linda Reese Richard & Dorene Rice Wililam Stoneman Donald Zach Ellen Hartenbach Dawn Reinecke Anthony & Mary Richard Strauss Erich Ziemann Joseph & Norma Harvath Mark Ritter Richtsmeier Don Sturtwant Donald Zima Jane Harvey Ian Robins Wayne Ritchie Reinold Suchomel Frank Zuerner Shirley Heimerl Lindsay Rommelfanger Eldon Roesler Ellagonda Sullivan Roger Zwickey Sharon Hodge Emanuel Rotter Mary Rogachuk Steve Sullivan Thomas Zylka Doug Hoffmann Jody Schwerdtfeger Rough Eileen Rolph Michelle Suter Matthew Hoffman Alvina Runde Alex Rose Dawn Tanner In Honor Of Will Holm Connie & Jan Ryan Maurice Rosefelt Nick Tarantino Honor gifts are given in Janeille Hornslein Barbara Schaefer Joan Rosenberg Howard Temin recognition of a loved one Steven Howard Albert Schams Elmer Rouse Richard Terwilliger who is living. A minimum Mary Lou Hudack Joan Schiller Geraldine Royko Karen Teschan gift of $100 has been Richard & Louise Jahnke Judy Schuster Ricky Rudisill Lorraine Teuke made in honor of the David Jarrard Nancy Schwerdtfeger James Ruosch Allen Thieleke individuals listed from Chris Johnson Ethlyn Shadel Roger Rusch Ron Thilleman July 1, 2005 to Ted Jones Judy Siegert Thomas Ryan Florence Thompson June 30, 2006. Sandra Joranlien Terri Smith June Saevre Raymond Thompson Mark Juckett Wendell & Kaitlyn Smith Constance Sahagian Constance Thurlow Colleen Adams Brad Kahl James Stewart Aurora Samuels Grover Tillett Eva Anderson Merlin Kanter Jane Straus G. Irving Schefelker Georgie Toms Abby Armstrong Pam Keating Michael Sturm Raymond Scheid Thomas Towell Timothy Bierman Mary Lorene Keller Geraldine Torti Adeline Schiefelbein Eva Townsend Carla Blum Thomas & Barbara Kilgore Diane Vesely Herbert Schlater David Tribbey Tara Breslin Doris Knox Berton Voise Michael Schmitt Keith Tripke Beverly Brown Michael Krebs Robert Wagner Sue Schneck Sheila Twesme George Bryan Hana Krembs John Wegenke Kenneth Schneider Irene Van Boxtel Nancy Burdick Johanna Krueger Robert Wegenke Lee Schoon Frances Van Nevel Nathan Byram Betty Kuhls Bill Weinert Merle Schuler Jay VanSloan Marlene Cable Diane Langeteig James Weiss George Schultz John Veatch Torrey Calkins Glenn Liu Tom & Susan Welch Gilmore Schultz Frances Venti Tom Callahan Thomas LoConte Peggy Wiederholt Robert Schultz Nelson Vike, Jr. Andrew Carr Walter Longo Carleen Wild Mary Schumacher Laurabelle Vinje Louise Carr Richard Love George Wilding Jack & Diana Schure Rudolph Vokovan Wesley Christianson Thomas Lucas David Williams & Alan Schwartz Suzanne Voss Roger Clark Bambi Maloney Carol Jefferson Nancy Schwerdtfeger Erwin Waedow Scott Clem Lynda Maselter Mary Wolf Henry Scoles Otto Wagner Corine Cohn Karen McCannon Jody & Sue Wolters Daniel See Dick Wakenight John & Marianne Cullen Richard McCormick Michael & Rowena Young Kathleen Semrad Florence Walsh Kathy DiPadova Judy Meyer Catherine Zdeblick Cindy Sexton Richard Walsh Mr. & Mrs. Tom Drake Karen Milner-Adams Steve Zelenski Darryl Shain Ted Walton Sandra Dykstra Aletha Mohlman Lucille Zimmerman Lawrence Shapiro Suzy Watson Kate Emerich Henry Mueller Andy Zucker Warren Shrake Terry Webb Brian Farrell Inamm Najem Roger Zwickey Elsie Siegel Loretta Weber John Fatura Steven Nelesen Ethel Siemion Thomas Weber Robert Fettig Robert Neuendorf Eddie Siersema Rob Wegenke Robert Siewert Conrad Weis Eleanor Silverman Marion Wermuth Myron Simonson Jung Werner Eugene Skaar Fred West Paul Skelley Betty Whaley George Sledge Leo Wiegand Robert Slopa Eileen Wild Alan Smith John Wild Betty Smith Nancy Wild John Smith Donald Wilke Mary Ziegler Smith Florene Wilke Charles Sommer Lorraine Wilkie Karl Southworth Richard Williams Max Sparger Stanley Wilson Leslie Sprecher Paul Wimann Malcolm Stack Beati Winn Francis Stadele Mark Wirtz Mary Ellen Stafford Jack Wise Robert Stanek Darlene Wisnefsky Brett Stanley Karl Woessner Pictured are golfers Dave Grant (event organizer), Kim Kalepp, Carleen Wild and Mike Robert Stare David Woeste Bidwell at the annual Lung Cancer Memorial Golf Outing held in Baraboo. Now in its Irvine Stein Paul Wolf fourth year, the event has raised just over $32,320 for the Creating Hope lung cancer campaign.

45 for the fiscal year ending june 30, 2006

Cancerfinancial iCenternformation

Operating Results for the Fiscal Years Ending June 30, 2006, 2005, 2004 and 2003 FISCAL 2006 FISCAL 2005 FISCAL 2004 FISCAL 2003 SOURCES OF SUPPORT

Grants and awards

Core grant from NCI $5,950,249 $5,012,413 $5,081,743 $4,982,378

Other federal awards 97,831,063 93,915,646 74,007,463 57,104,445

Industry and other 15,932,403 17,858,051 12,709,340 7,819,247

119,713,715 116,786,110 91,798,546 69,906,070

Contributions 5,423,742 4,600,175 3,706,914 2,428,539

University of Wisconsin

School of Medicine and Public Health 853,141 920,271 1,000,820 967,617 R esults operating operating All other 46,000 60,830 47,825 148,434

899,141 981,101 1,048,645 1,116,051

Fees for research support services 1,479,850 1,321,496 955,921 459,530

Investment earnings 984,357 739,070 804,204 1,044,284

TOTAL SUPPORT 128,500,805 124,427,952 98,314,230 74,954,474

EXPENDITURES

Salaries and benefits 61,801,409 58,326,534 47,791,234 37,467,901

Equipment 2,662,573 2,022,249 1,613,682 1,290,836

Services and supplies 11,422,570 11,166,212 10,041,091 6,769,779

Travel 1,525,488 1,649,753 1,254,724 867,290

Other expenses 21,362,185 18,705,380 13,058,466 10,365,935

Overhead support to UW-Madison 29,945,866 27,857,459 23,479,837 16,976,709

TOTAL EXPENDITURES 128,720,091 119,727,587 97,239,034 73,738,450

SUPPORT GREATER THAN ($219,286) $4,700,365 $1,075,196 $1,216,024 (LESS THAN) EXPENDITURES

During fiscal 2006 total support increased to $128.5 million or an increase of 3.3%. Support from contributions totaled just over $5.4 million or an increase of 18% during the year. Since fiscal 2003 contributions have grown 123%.

Total expenditures in fiscal 2006 reached $128.7 million. As in prior years, salaries and benefits represented the largest component of expenditures at 48% of total expenditures.

46 McArdle Lab—9% Expenses by member department All Others—20% During the year ending June 30, 2006, research and training-related expenditures Medicine—13% were incurred in more than 40 UW schools and departments. The Cancer Center member School of Pharmacy—4% departments cover a wide range of disciplines Population Health Surgery—3% across the UW campus. The two largest Sciences—5% departments as measured by expenditures Ophthalmology—2% Cancer Center were the Department of Medicine and the Core Grant—5% Pediatrics—4% McArdle Laboratory for Cancer Research. Chemistry—3% Pathology—8%

College of Agricultural & Pharmacology—5% Life Sciences—6% College of Human Oncology—3% Engineering—6% School of Veterinary Medicine—4%

$150,000,000 UWCCC Member support ALL OTHERS As of July 1, 2006 Cancer Center member $120,000,000 NIH annual external research and training support NCI totaled $140.3 million, a decline of just $90,000,000 under 1%. This small decrease reflects the $6,0000,000 tight federal budget and the trend for longer intervals between funding of NIH grants and $30,000,000 automatic budget decreases in funded 0 NIH grants. FY 2000 FY 2001 FY 2002 FY 2003 FY 2004 FY 2005 FY 2006

Construction Grant—4.99%

Core Grant—3.98% UWCCC programs Cancer Control & Population Science—18.60% This chart presents the level of external (44 members) Experimental support for the Cancer Center’s program Therapeutics—16.76% (46 members) areas for the fiscal year starting July 1, 2006. In addition to the program areas, the Cancer Center receives external support for its Core Grant and funding for cancer-research Human Cancer facilities. Cancer Cell Virology—4.85% Biology—20.48% (11 members) (47 members) Imaging & Radiation Sciences—6.50% (42 members)

Etiology & Cancer Genetics—16.91% Chemoprevention—6.93% (22 members) (21 members)

47 “We make a living by what we get, but we make a life by what we give.” –winston churchill

ContributionsA commitment to the future Your gift to the UW Paul P. contact your human resources PLANNED GIVING, in the Carbone Comprehensive Cancer office or our development office, form of gift annuities, charitable Center supports greater innovative (608) 263-1677. remainder trusts or designating research initiatives, compassionate the Center in your will, is also cancer care and education MEMORIAL AND HONOR an option. The UW Paul P. for the public and health care GIFTS allow contributors to Carbone Comprehensive Cancer professionals. recognize loved ones in a special Center can also be named as a way. Memorial gifts are made beneficiary of retirement plans, Your contribution also enables in memory of family members, trusts or life insurance policies. our researchers to explore new friends or colleagues who have The Office of Planned Giving ideas, purchase new technology passed away. Honor gifts show at the University of Wisconsin for effective cancer research, someone in your life a measure of Foundation can assist in and develop better methods affection, admiration or gratitude. planning these gifts. Please call of diagnosing, treating and When such gifts are made, a (608) 263-4545. preventing cancer. special notification is sent to the hope family or individual. CONTRIBUTING ONLINE Funding for the Cancer Center’s is possible by going to research, outreach and treatment MAJOR GIFTS are a specific www.uwhealth.org. Choose the programs is more important than way for individuals, organizations, “Donate” button and then select ever. There are many ways to corporations or foundations to one of the Cancer Center support the UW Carbone Cancer contribute to the University of funds listed. Center (UWCCC): Wisconsin School of Medicine and Public Health’s HealthStar The University of Wisconsin UNRESTRICTED GIFTS are truly campaign. Funds from this Foundation is the official valuable because they provide campaign will help build the fundraising and gift-receiving the flexibility needed for research Interdisciplinary Research organization for the Cancer to move quickly in unexpected Complex, which will prominently Center. For specific information directions and to swiftly pursue feature the UW Paul P. Carbone about these giving options, visit promising clinical applications. Comprehensive Cancer Center the UW Foundation’s website: Unrestricted gifts also provide and innovative research. Please www.uwfoundation.wisc.edu resources to cover the costs of call (608) 263-1677 for more critical services not entirely funded information. FOR MORE INFORMATION by other support. about contributing to the UW ENDOWMENTS to sustain Paul P. Carbone Comprehensive DESIGNATED GIFTS benefit programmatic development are an Cancer Center, please contact: specific programs of your choice. option to create a lasting legacy in Funds may be designated for the benefactor’s name. Ann Johnson initiatives in specific areas of UW Paul P. Carbone cancer research, patient care and OTHER EXAMPLES OF GIVING Comprehensive Cancer Center educational needs. include purchasing research 600 Highland Avenue, K4/658 equipment, funding fellowship or Madison, WI 53792-6164 CORPORATE MATCHING GIFTS research programs, sponsoring are an excellent way to increase special events, or underwriting (608) 263-1677 your giving potential to the Center. programs for the community or [email protected] For more information, please health care professionals.

48 CREDITS PHOTOGRAPHY Jerome Rather FOR MORE INFORMATION CONTRIBUTIONS Todd Brown Lori Saffian For patient services at To contribute to the UW Paul Michael Lemberger Teresa Smith the UW Paul P. Carbone P. Carbone Comprehensive EDITORS Tom McInvaille Stephine Wasielewski Comprehensive Cancer Center, Cancer Center, please contact: Craig Robida David Nevala Jane Wegenke please contact: UW Paul P. Carbone Ann Johnson George Wilding Comprehensive Cancer Center UW Paul P. Carbone CONTRIBUTORS Cancer Connect Comprehensive Cancer Center Rhoda Arzoomanian SPECIAL THANKS (800) 622-8922 or Linda Dietrich 600 Highland Avenue, K4/658 Andrea Engebretson Judy De Muth (608) 262-5223 UW Health Marketing & Madison, WI 53792-6164 Gayla Garlick-Hansen William Dove [email protected] Public Affairs (608) 263-1677 Paula Goode David Gustafson [email protected] F. Michael Hoffmann For information on the latest ART DIRECTION AND Ann Johnson Brad Kahl research initiatives, news and GRAPHIC DESIGN Jan Johnson COPYRIGHT Michael Lemberger upcoming events, view the Christine Klann Mary Makarushka © 2007 Rebecca Marnocha UW Carbone Cancer Center UW Health Marketing & Ashley McGuire UW Paul P. Carbone Kathy Schell website: www.cancer.wisc.edu Public Affairs Bob Millholland Comprehensive Cancer Center 600 Highland Avenue Madison, WI 53792 (608) 263-8600 www.cancer.wisc.edu NCI CCC

UW Health is a patient-focused, The University of Wisconsin The UW Paul P. Carbone three-pronged academic health system School of Medicine and Public Comprehensive Cancer Center supported by: Health is recognized as an is one of only 38 comprehensive • university of Wisconsin Hospital and international leader in educating cancer centers designated by the Clinics, a 471-bed facility that ranks physicians, investigating the National Cancer Institute, the lead among the finest hospitals in the causes of disease, finding federal agency for cancer research. United States. innovative solutions to medical problems and translating research • university of Wisconsin School of into compassionate patient care. Medicine and Public Health, the UW-Madison campus home of the faculty members who do research, teach and provide patient care. • university of Wisconsin Medical Foundation, the academic group practice that supports the clinical faculty of the UW School of Medicine and Public Health, including more than 1,000 physicians who practice at 50 locations.

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