Drug Group Mechanism Indications Special Toxicity of action Arsenic trioxide Natural Differentiation APL, refractory to Prolonged QT product, of APL cells ATRA interval, differentiating APL agent differentiation syndrome Altretamine Alkylating DNA cross- Ca ovary (2nd line) agent (non- link formation classic) L-Asparaginase Enzyme Hydrolyses L- ALL Hypersensitivity, (derived from Asparagine & Bleeding E Coli) thereby diathesis & prevents hypercoagubility, protein Acute synthesis in pancreatitis tumor cells Bexarotene Retinoid, Cellular CTCL Hyperlipidemia, differentiating differentiation hypothyroidism agent Busulfan Alkylating DNA cross- CML, BMT Lung fibrosis agent link formation Chlorambucil Alkylating DNA cross- CLL, HD, NHL Lung fibrosis agent link formation Dacarbazine Atypical Malignant alkylating melanoma, HD agent Dactinomycin Antitumor Alkylating STS, WT antibiotic agent Denileukin Immunotherapy IL-2 + Recurrent/ Capillary-leak diftitox diphtheria refractory CTCL syndrome, Flu- toxin like syndrome Estramustine Anti- Estradiol + Hormone- microtubule nornitrogen refractory agent mustard metastatic prostate cancer FUDR Anti-metabolite Prevention of Liver metastasis Hepatitis, Peptic DNA (from CRC/ ulcer synthesis gastric ca) Hydroxyurea Anti-metabolite Inhibition of CML, other DNA myeloproliferativ synthesis e disorders Mitotane Adrenolytic Inhibition of Adrenal cortical agent (derived adrenal steroid carcinoma from production inseciticide DDD) Procarbazine Alkylating Inhibits DNA, HD, NHL, Brain agent (MAO RNA & tumors inhibitor) protein synthesis Streptozocin Alkylating DNA cross- Pancreatic islet agent link formation cell cancer, (Nitrosourea) Carcinoid tumor Tretinoin/ATRA Retinoid, Differentiation APL Retinoic acid differentiating of APL cells syndrome agent