RIMADYL Is the #1 NSAID – for So Many Reasons!
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RIMADYL is the #1 NSAID – for so many reasons! Features/Functions: Flexible – Indicated for control of pain associated with soft tissue and orthopedic procedures and for relief of osteoarthritis pain. Flexible Formulations – Injectable formulation to circumvent oral absorption issues and for easier in-clinic administration; palatable chew formulation for improved compliance at home; caplet formulation for dogs with allergies to meat proteins. Flexible Dosing – Once or twice daily dosing to meet medical and scheduling needs in the clinic and home. Benefit: Rimadyl works with your clinic staff and your clients to provide continuous pain relief for dogs from the clinic to the home. Features/Functions: Palatable – RIMADYL Chewable is highly palatable and was readily accepted by >93% of dogs.1 RIMADYL Rewards – An extensively supported program that triples compliance rates2 while saving pet owners money they can spend on additional services and medications at your clinic. Benefit: With Rimadyl and Rimadyl Rewards, your canine osteoarthritis patients are positioned for optimal treatment outcomes through your clinic Features/Functions: Trusted – Since 1996, RIMADYL has been used to relieve pain and inflammation associated with osteoarthritis in more than 24 million dogs.3 Trusted – Since 2003, RIMADYL Injectable has been used to safely control post-operative pain in more than 10 million dogs4 as young as 6 weeks. Proven – Backed by 20 years of research and science, with more than 140 peer-reviewed articles confirming safety and efficacy, RIMADYL is the first and original NSAID that is FDA-approved for dogs. Supported – Since 1996, veterinarians, technicians, and dog owners have been able to count on medical support by the Zoetis Veterinary Medical Information and Product Support Team. Benefit: With RIMADYL, you and your clients can be confident in your NSAID choice. IMPORTANT SAFETY INFORMATION: As a class, NSAIDs may be associated with gastrointestinal, kidney and liver side effects. These are usually mild, but may be serious. Pet owners should discontinue therapy and contact their veterinarian immediately if side effects occur. Evaluation for pre-existing conditions and regular monitoring are recommended for pets on any medication, including RIMADYL. Use with other NSAIDs or corticosteroids should be avoided. See full Prescribing Information on page XX. 1. Payne / Johnson M, TP Maitland, J. Bullard and J. Gossellin. Comparative palatability of three commercial formulations of Carprofen and one commercial formulation of firocoxib in dogs. Review Méd. Vet., 2006, 157 (809), 431-AR-01022. 2. Rimadyl Rewards Program Metrics, December TI-02465. 3. 2015-12 Trends Data NSAID V2 BIAHP-199 Rimadyl TI-02367. 4. RIMADYL Injectable Pharmacovigilance Report, 2003-2013, data on file, Zoetis, Inc. All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. ©2017 Zoetis Services LLC. RIM-00225 SEE HOW RIMADYL COMPARES A label-to-label comparison of RIMADYL® (carprofen) and Galliprant® (grapiprant).† VS. RIMADYL (carprofen) GALLIPRANT (grapiprant) CLASS AND INDICATIONS FDA Approved • Relief of pain and inflammation associated with • Control of pain and inflammation Indications osteoarthritis in dogs associated with osteoarthritis in dogs • Control of postoperative pain associated with soft tissue surgery in dogs • Control of postoperative pain associated with orthopedic surgery in dogs US Usage • #1 veterinary prescribed NSAID since 19961 • FOI summary data available on 453 1 Record • 24 million dogs treated orally in US dogs from target animal safety and field • 10 million dogs treated subcutaneously efficacy and safety studies Drug Class • Non-steroidal anti-inflammatory drug • Non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class (NSAID) of the piprant class DOSE/ADMINISTRATION Dosing • 2 mg/lb (4.4 mg/kg) of body weight once daily or divided • 0.9 mg/lb (2mg/kg) once daily orally Flexibility and administered as 1 mg/lb (2.2 mg/kg) twice daily • 20 mg, 60 mg, 100 mg tablets • Once or twice daily • 25 mg, 75 mg, 100 mg chewable tablets or caplets • Proven Palatability2 • Injectable solution Age Restrictions • 6 weeks • 9 months ADVERSE EVENTS* Incidence of • OA: 3.1% (4 of 129) vs. 3.8% (5 of 132) in placebo group • OA: 17% (24 of 141) vs. Vomiting – • Orthopedic: 10.1% (17 of 168) vs. 9.2% 6.3% (9 of 144) in placebo group Clinical (15 of 163) in placebo group Field Study • Soft tissue: 10.1% (15 of 148) vs. 13.4% (20 of 149) in placebo group Incidence of • OA: 3.1% (4 of 129) vs. 4.5% (6 of 132) in placebo group • OA: 12% (17 of 141) vs. Diarrhea – • Orthopedic: 2.4% (4 of 168) vs. 3.7% (6 of 163) 9% (13 of 144) in placebo group Clinical • Soft tissue: 6.1% (9 of 148) vs. 6.0% (9 of 149) Field Study As the #1 veterinary prescribed NSAID for dogs since 1996, you can trust RIMADYL with your dog’s pain management.3 †Data sourced from FDA-approved labels. 1VetInsight Analytics. September 2012. Data on file. MDI market research. Zoetis Inc. 2Payne-Johnson M, T.P. Maitland, J. Bullard and J. Gossellin. Comparative palatability of three commercial formulations of carprofen and one commercial formulation of firocoxib in dogs. Revue Méd. Vet., 2006, 157, 809, 431-440. 3Vetinsight Analytics, December 2015 GALLIPRANT® is a trademark of Aratana Therapeutics, Inc. *This is only a comparison of labels and not a head-to-head comparison of safety. All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. © 2017 Zoetis Services LLC. RIM-00225 Check-Off (Qualify) Identify if a Zoetis representative has recently discussed RIMADYL: Sound Doctor, are you familiar with the RIMADYL Rewards program? CHECK-OFF & If YES, confirm benefits. ECHO NOTES If NO, then detail as the primary contact. Confidence Invitation to neutral Since the start of the program, RIMADYL Rewards Let’s take a look at some basic information about RIMADYL and its reward program… participants have spent $4.6 million worth of rewards points at their clinics.1 It’s the customer’s decision Plus, purchases of RIMADYL help support our … RIMADYL is the # 1 NSAID for so many reasons: flexibility for your clinic, K9 heroes through our RIMADYL K9 Courage Program. client and patients; greater compliance at home and return visits to your clinic; www.Rimadylk9courage.com. confidence because of its unparalleled track record and support. ® Cl Percentage of Dogs with Abnormal Health Observations Reported in Clinical Field Study with the Injectable O Observation Rimadyl (n=168) Placebo (n=163) Vomiting 10.1 9.2 (carprofen) OH Diarrhea/soft stool 2.4 3.7 Dermatitis 0.6 1.2 Caplets/Chewable Tablets N Dysrhythmia 0.6 0.6 CH3 Swelling 0 1.2 For oral use in dogs only Dehiscence 1.2 0 Sterile Injectable Solution 50 mg/mL H WBC increase 13.7 6.7 For subcutaneous use in dogs only * A single dog may have experienced more than one occurrence of an event. Post-Approval Experience: Non-steroidal, anti-inflammatory drug Although not all adverse reactions are reported, the following adverse reactions are based on voluntary post-approval adverse drug experience reporting. The categories of adverse reactions are listed in decreas ing order of frequency by body system. CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Gastrointestinal: Vomiting, diarrhea, constipation, inappetence, melena, hematemesis, gastrointestinal ulceration, gastrointestinal bleeding, pancreatitis. DESCRIPTION: Rimadyl (carprofen) is a non-steroidal anti-inflamma tory drug (NSAID) of the propionic acid class that includes ibuprofen, naproxen, and Hepatic: Inappetence, vomiting, jaundice, acute hepatic toxicity, hepatic enzyme elevation, abnormal liver function test(s), hyperbilirubinemia, bilirubinuria, ketoprofen. Carprofen is the nonproprietary designation for a substi tuted carbazole, 6-chloro-α-methyl-9H-carbazole-2-acetic acid. The empirical formula hypoalbuminemia. Approximately one-fourth of hepatic reports were in Labrador Retrievers. is C15H12ClNO2 and the molecular weight 273.72. The chemical structure of carprofen is shown above. Carprofen is a white, crystalline compound. It is Neurologic: Ataxia, paresis, paralysis, seizures, vestibular signs, disorientation. freely soluble in ethanol, but practically insoluble in water at 25°C. Urinary: Hematuria, polyuria, polydipsia, urinary incontinence, urinary tract infection, azotemia, acute renal failure, tubular abnormalities including acute Rimadyl Injectable is a sterile solution containing carprofen. Each mL of Rimadyl Injectable contains 50.0 mg carprofen, 30.0 mg arginine, 88.5 mg glycocholic tubular necrosis, renal tubular acidosis, glucosuria. acid, 169.0 mg lecithin, 10.0 mg benzyl alcohol, 6.17 mg sodium hydroxide, with additional sodium hydroxide and hydrochloric acid as needed to adjust pH, Behavioral: Sedation, lethargy, hyperactivity, restlessness, aggressiveness. and water for injection. Hematologic: Immune-mediated hemolytic anemia, immune-mediated thrombocytopenia, blood loss anemia, epistaxis. CLINICAL PHARMACOLOGY: Carprofen is a non-narcotic, non-steroidal anti-inflammatory agent with characteristic analgesic and antipyretic activity Dermatologic: Pruritus, increased shedding, alopecia, pyotraumatic moist dermatitis (hot spots), necrotizing panniculitis/vasculitis, ventral ecchymosis. approximately equipotent to indomethacin in animal models.1 In rare situations, injection site reactions including necrosis,