Webtable 3. Acute myeloid leukaemia

Treatment Phenotype Age n Web ref* complications Trimester 1 , Normal .. 2 .. 6,55 , cytarabine Normal 4 years 1 .. 22 Doxorubicin, , , Normal 6 years 1 .. 22 , cytarabine, prednisone Doxorubicin, vincristine, cytarabine, prednisone Normal 5 years 1 .. 22 Doxorubicin, mercaptopurine, methotrexate, Normal 16 years 1 .. 23 cytarabine, prednisone Mercaptopurine, methotrexate, cytarabine Normal 7 years 1 .. 24 Vincristine, mercaptopurine, methotrexate, Normal 2–7 years 2 Transient anaemia 24,47 cytarabine, daunorubicin Doxorubicin, , cytarabine Normal 1 month 1 .. 31 Mercaptopurine Normal .. 1 Haemolytic anaemia, 45 palpable spleen Doxorubicin, vincristine, cytarabine, Atrial septal defect, absent fifth digit 1 .. 46 prednisone bilateral, absent radii bilateral Daunorubicin Normal 1 .. 48 Daunorubicin, Normal 5 years 2 .. 49,50 Tioguanine, cytarabine, then vincristine, Grossly normal fetus .. 1 Elective termination of 51 daunorubicin pregnancy at 20 weeks Tioguanine, cytarabine Brachycephaly, hypoplastic 15 months 1 .. 52 midface, craniosynostosis, hypoplastic thumbs, absent radii, normal neurodevelopment Tioguanine, cytarabine Normal karyotype, normal .. 1 .. 53 development, 2 digits absent on both feet, absent distal phalanges on both thumbs Tioguanine, cytarabine Normal .. 2 .. 53,54 Trimester 2 Doxorubicin, tioguanine, cytarabine No anomalies .. 1 Stillbirth at 26 weeks, 7 bruising, petechiae, platelets not reported Doxorubicin, mercaptopurine, cytarabine, Normal 8 years 1 .. 23 prednisone Tioguanine, cytarabine, daunorubicin Normal 22 months 12 One case with premature 24,25,42, rupture of membranes 47,57,58 at 30 weeks Vincristine, , cytarabine, Normal 6 years 1 .. 30 daunorubicin Vincristine, cyclophosphamide, tioguanine, Normal 11 years 1 .. 30 cytarabine, prednisone, daunorubicin Tioguanine, cytarabine, prednisone, Normal autopsy, placenta .. 1 IUFD at 20 weeks, small 42 daunorubicin without leukaemic infiltration gestational age, maternal haemoglobin 49 g/L, Vincristine, tioguanine, cytarabine, prednisone, Normal .. 1 IUGR 50 daunorubicin Vincristine, tioguanine, cytarabine, prednisone, Normal .. 1 .. 50 daunorubicin Doxorubicin, vincristine, tioguanine, cytarabine, Normal .. 1 IUGR at 31 weeks 55 prednisone Mercaptopurine, daunorubicin Normal .. 1 IUFD 55 Cytarabine, daunorubicin Normal .. 1 IUFD at 17 weeks 55 Mercaptopurine, cytarabine, daunorubicin Normal .. 2 .. 55,58 Doxorubicin, vincristine, cytarabine, prednisone Normal .. 1 .. 56 Mercaptopurine Normal .. 1 .. 58 Mercaptopurine, cytarabine, prednisone, Normal .. 1 Abruption at 33 weeks, 59 daunorubicin 1 day after PUBS; IUGR, anaemia Continued...

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Treatment Phenotype Age n Pregnancy Web ref* complications Vincristine, mercaptopurine, methotrexate, Normal 2 years 1 Pre-eclampsia 60 prednisone , Normal, transient right-sided .. 1 Mild respiratory-distress 61 dilated cardiomyopathy syndrome Cytarabine, tretinoin, Normal 4 months 1 .. 62 Tioguanine, cytarabine Normal, autopsy, therapeutic .. 1 Trisomy C, POCS 63 abortion Tioguanine, cytarabine No anomalies .. 1 IUFD at 24 weeks 64 Cytarabine, idarubicin Normal .. 1 IUGR, transient, mildly 65 increased transaminases and erythroblastosis Cytarabine, daunorubicin, , mitoxantrone Normal 2 months 1 IUGR, pancytopenia 66 Cytarabine, daunorubicin, idarubicin, No anomalies .. 1 IUFD at 2 days after con- 67 mitoxantrone solidation with idarubicin Tioguanine, cytarabine, daunorubicin, allopurinol Normal .. 1 .. 68 Tioguanine, cytarabine, daunorubicin, allopurinol No anomalies .. 1 Severe pre-eclampsia, 68 IUFD at 29 weeks Trimester 3 . Cytarabine, prednisone, daunorubicin Normal 9 years 1 .. 24 Tioguanine, cytarabine, daunorubicin At age 2 years: adherence .. 1 .. 30 of iris to cornea in left eye Cytarabine, daunorubicin Normal 3 years 1 IUGR 47 Vincristine, tioguanine, cytarabine, prednisone, Normal autopsy .. 1 Maternal/fetal 50 daunorubicin Mercaptopurine, prednisone, methylglyoxalbis Normal .. 1 .. 55 guanyl hydrazone Normal .. 1 Premature rupture of 69 membranes at 34 weeks Tioguanine, cytarabine Normal, normal karyotype 2 years 4 .. 70–73 Doxorubicin, vincristine, tioguanine, cytarabine Normal .. 1 .. 74 Tioguanine, cytarabine, prednisone Normal .. 1 .. 75 Trimesters 2 and 3 Doxorubicin, tioguanine, cytarabine Normal .. 3 .. 13,33,78 Vincristine, tioguanine, cytarabine, prednisone, Normal 13 months 2 IUGR in one case 16 daunorubicin, Doxorubicin, cytarabine Normal 14 months– 3 Elective preterm delivery at 23,35,79 15 years 31 weeks in one case; due to respiratory-distress syn- drome and pneumothorax Cytarabine Normal 1 year3 .. 31,47,64 Vincristine, cytarabine, prednisone Normal 4 years 3 .. 34,56,77 Tioguanine, cytarabine, daunorubicin, etoposide, Normal .. 3 Premature rupture of 76 mitoxantrone membranes at 34 weeks

IUFD, intrauterine fetal death; IUGR, intrauterine growth restriction; PUBS, periumbilical blood sampling; POCS, products of conception. *These references are available only on the web, see http://image.thelancet.com/extras/03oncl0502webfr.pdf.

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