Table S3. Irf6 related genes involved in different biological process analysed by DAVID database
List Pop Pop Fold Term Count % P -Value Genes Bonferroni Benjamini FDR Total Hits Total Enrichment
TBK1, IL18, TLR1, TLR2, TLR3, TLR4,
TNFSF12, TLR5, TLR7, TLR8, IL10,
TGFB1, TAPBP, TLR9, LILRA1, MYD88,
IFNG, IL1B, ERAP1, ERAP2, FAS, IL1A,
CIITA, GBP7, BCL10, CRTAM, GBP5,
RELA, RELB, HLA-DQA2, TRAT1,
PDCD1LG2, HLA-DQA1, LILRB2, CCR6,
LILRB5, CD40LG, VEGFA, CCR2,
MADCAM1, HLA-DPA1, DEFA1, GBP4,
EDA, GBP3, KIR3DL1, GBP2, HLA-DRA,
9.85185185 MAVS, IL1R2, IL1R1, IFIH1, HLA-DRB1, 1352 5.59564595 9.36E-6 GO:0006955~immune response 133 5.19E-64 466 690 1.58E-60 1.58E-60 2 IFITM2, HLA-DRB3, OAS3, OAS2, IFI35, 8 4 1
PVRL1, ICOS, HLA-DRB4, HLA-DRB5,
HLA-DPB1, HLA-DOA, TRAF6, TBKBP1,
HLA-DOB, BLNK, TLR10, CARD9,
IL1RN, KIR2DS2, SMAD3, KIR2DS1,
MALT1, AIM2, DDX58, BTLA, IKBKE,
CBLB, NOTCH1, OASL, TNFSF11,
IKBKG, CD274, IFI6, CD8A, TOLLIP,
ZEB1, NFKB2, HLA-DMB, HLA-DMA,
PDCD1, CD96, RAET1E, IL1RAP,
TICAM1, LBP, FCGR3A, CHUK, INPPL1, TP53, CTSS, ULBP3, ULBP2, ICOSLG,
PTAFR, HLA-DQB1, CSF2, TNF, PRKDC,
CALCOCO2, NLRX1, IL7R, RNF125,
TNFRSF1A, IGF1R, TNFRSF1B,
DEFA1B, TAP2, TAP1, IL2RG, INPP5D,
CD28, IL3, IL6, IL5, IL2RA, IL7, CTLA4,
CYBB, FCGR2B, IRF8, CD14, IL2
NOG, PTGS2, IL18, PTGS1, STAT5B,
TGFB3, JAG2, FGF10, TNFSF12, TGFB1,
IL10, TGFB2, CUL3, MYD88, CDKN2A,
APOE, ILK, IFNG, IL1B, IL1A, SYK,
EGFR, IRS2, RARG, EFNB1, RXRA,
RELA, CD40, IRS1, PDCD1LG2, PTHLH,
MSX1, VEGFA, FOXG1, RIPK2,
EIF2AK2, FGFR2, FGFR1, CAV1, STK11,
ERBB2, NFKBIA, IFI30, SOX4, SOX9, GO:0042127~regulation of cell 1352 4.16822725 4.02E-3 113 8.37037037 2.23E-40 VDR, RUNX2, BMP4, PTPN6, BMP2, 466 787 6.80E-37 3.40E-37 proliferation 8 5 7 MLL, SMAD4, SMAD3, SMAD2, SMAD1,
FOXP3, AGER, CDKN1C, BTLA, CBLB,
NOTCH1, CDKN1A, CDKN1B, DLX5,
CD274, FGF9, PAX6, TP63, PAWR,
PAX3, ZEB1, GLI2, PTEN, GLI3, EDNRB,
TNFRSF11A, TICAM1, MYC, PRL,
UBE2A, TP53, RB1, ESR2, CARD11,
SMO, CD81, NGFR, ICOSLG, CSF2, TNF,
PML, KITLG, SFN, KIT, ZBTB16, VCAM1, IGF1R, PTK2B, CAMK2D,
INPP5D, APC, CD28, TXNIP, IL3, IL6,
IL5, IL2RA, IL7, CTLA4, STAT1, IRF6,
PBX1, IL2
DZIP3, VPRBP, CUL3, CUL7, KLHL9,
ATG7, FBXO27, RBCK1, ERAP1, SOCS3,
RELA, SOCS1, UBE2J1, UBR4, UBR2,
UBR1, UBE2J2, ASB9, ASB8, FBXO17,
TRIM32, ASB1, RNF25, ASB3, PIAS1,
ASB2, TNFAIP3, ASB5, ASB4, ASB7,
ASB6, ASB12, UBA6, ASB11, CDC34,
ASB16, ASB15, ASB18, ASB17, FBXW7,
FBXW8, ASB10, FBXO6, FBXO44,
HECTD3, FBXO4, TRAF6, FBXO2,
GO:0051603~proteolysis involved in 7.25925925 MALT1, UBOX5, TRIM63, P2RX7, CBLB, 1352 4.74157367 3.01E-3 98 1.67E-39 466 600 5.08E-36 1.69E-36 cellular protein catabolic process 9 UBA1, NEDD4, UBA3, UBE2E2, 8 7 6
UBE2G2, NFKB1, MGRN1, KLHL21,
KLHL20, UBE2A, GAN, UBE2B, PJA2,
UBE2N, UBE2O, PJA1, KLHL13, NGFR,
OTUD5, UBE2Z, UBE3B, UBE3C,
ZBTB16, TRIM11, UBE2R2, RNF125,
CYLD, RNF123, NEDD4L, TRIP12,
RNF144B, LRSAM1, SPSB1, UBE4A,
LRRC41, CBL, SPSB2, SPSB4, PARK2,
UBE2Q1, CISH, WSB1, DET1, RNF111,
RNF41 DZIP3, VPRBP, CUL3, CUL7, KLHL9,
ATG7, FBXO27, RBCK1, ERAP1, SOCS3,
RELA, SOCS1, UBE2J1, UBR4, UBR2,
UBR1, UBE2J2, ASB9, ASB8, FBXO17,
TRIM32, ASB1, RNF25, ASB3, PIAS1,
ASB2, TNFAIP3, ASB5, ASB4, ASB7,
ASB6, ASB12, UBA6, ASB11, CDC34,
ASB16, ASB15, ASB18, ASB17, FBXW7,
FBXW8, ASB10, FBXO6, FBXO44,
HECTD3, FBXO4, TRAF6, FBXO2,
GO:0044257~cellular protein catabolic 7.25925925 MALT1, UBOX5, TRIM63, P2RX7, CBLB, 1352 4.71798375 4.67E-3 98 2.59E-39 466 603 7.89E-36 1.97E-36 process 9 UBA1, NEDD4, UBA3, UBE2E2, 8 8 6
UBE2G2, NFKB1, MGRN1, KLHL21,
KLHL20, UBE2A, GAN, UBE2B, PJA2,
UBE2N, UBE2O, PJA1, KLHL13, NGFR,
OTUD5, UBE2Z, UBE3B, UBE3C,
ZBTB16, TRIM11, UBE2R2, RNF125,
CYLD, RNF123, NEDD4L, TRIP12,
RNF144B, LRSAM1, SPSB1, UBE4A,
LRRC41, CBL, SPSB2, SPSB4, PARK2,
UBE2Q1, CISH, WSB1, DET1, RNF111,
RNF41
DZIP3, VPRBP, CUL3, CUL7, KLHL9,
7.33333333 ATG7, FBXO27, RBCK1, ERAP1, SOCS3, 1352 4.62053737 1.12E-3 GO:0030163~protein catabolic process 99 6.20E-39 466 622 1.89E-35 3.78E-36 3 RELA, SOCS1, UBE2J1, UBR4, UBR2, 8 8 5
UBR1, UBE2J2, ASB9, ASB8, FBXO17, TRIM32, ASB1, RNF25, ASB3, PIAS1,
ASB2, TNFAIP3, ASB5, ASB4, ASB7,
ASB6, ASB12, UBA6, ASB11, CDC34,
ASB16, ASB15, ASB18, ASB17, FBXW7,
FBXW8, ASB10, FBXO6, FBXO44,
HECTD3, FBXO4, TRAF6, AXIN1,
FBXO2, MALT1, UBOX5, TRIM63,
P2RX7, CBLB, UBA1, NEDD4, UBA3,
UBE2E2, UBE2G2, NFKB1, MGRN1,
KLHL21, KLHL20, UBE2A, GAN,
UBE2B, PJA2, UBE2N, UBE2O, PJA1,
KLHL13, NGFR, OTUD5, UBE2Z,
UBE3B, UBE3C, ZBTB16, TRIM11,
UBE2R2, RNF125, CYLD, RNF123,
NEDD4L, TRIP12, RNF144B, LRSAM1,
UBE4A, SPSB1, LRRC41, CBL, SPSB2,
SPSB4, PARK2, UBE2Q1, CISH, WSB1,
DET1, RNF111, RNF41
DZIP3, UBE2G2, VPRBP, CUL3, CUL7,
MGRN1, FBXO27, KLHL9, ATG7,
KLHL21, RBCK1, KLHL20, UBE2A,
GO:0019941~modification-dependent 6.88888888 SOCS3, SOCS1, UBE2J1, UBR4, UBR2, 1352 4.70347385 7.95E-3 93 4.40E-37 466 574 1.34E-33 2.24E-34 protein catabolic process 9 GAN, UBR1, UBE2J2, UBE2B, UBE2N, 8 3 4
PJA2, ASB9, ASB8, UBE2O, PJA1,
FBXO17, TRIM32, RNF25, KLHL13,
ASB1, ASB3, PIAS1, ASB2, ASB5, TNFAIP3, ASB4, ASB7, ASB6, OTUD5,
UBE2Z, UBE3B, ASB12, UBA6, ASB11,
CDC34, ZBTB16, UBE3C, ASB16, ASB15,
ASB18, UBE2R2, ASB17, TRIM11,
RNF125, CYLD, FBXW7, RNF123,
FBXW8, ASB10, FBXO6, HECTD3,
FBXO44, FBXO4, NEDD4L, TRAF6,
TRIP12, RNF144B, LRSAM1, SPSB1,
UBE4A, LRRC41, CBL, SPSB2, FBXO2,
SPSB4, MALT1, PARK2, UBOX5,
TRIM63, UBE2Q1, CISH, WSB1, CBLB,
UBA1, NEDD4, UBA3, DET1, UBE2E2,
RNF111, RNF41
DZIP3, UBE2G2, VPRBP, CUL3, CUL7,
MGRN1, FBXO27, KLHL9, ATG7,
KLHL21, RBCK1, KLHL20, UBE2A,
SOCS3, SOCS1, UBE2J1, UBR4, UBR2,
GAN, UBR1, UBE2J2, UBE2B, UBE2N,
PJA2, ASB9, ASB8, UBE2O, PJA1, GO:0043632~modification-dependent 6.88888888 1352 4.70347385 7.95E-3 93 4.40E-37 FBXO17, TRIM32, RNF25, KLHL13, 466 574 1.34E-33 2.24E-34 macromolecule catabolic process 9 8 3 4 ASB1, ASB3, PIAS1, ASB2, ASB5,
TNFAIP3, ASB4, ASB7, ASB6, OTUD5,
UBE2Z, UBE3B, ASB12, UBA6, ASB11,
CDC34, ZBTB16, UBE3C, ASB16, ASB15,
ASB18, UBE2R2, ASB17, TRIM11,
RNF125, CYLD, FBXW7, RNF123, FBXW8, ASB10, FBXO6, HECTD3,
FBXO44, FBXO4, NEDD4L, TRAF6,
TRIP12, RNF144B, LRSAM1, SPSB1,
UBE4A, LRRC41, CBL, SPSB2, FBXO2,
SPSB4, MALT1, PARK2, UBOX5,
TRIM63, UBE2Q1, CISH, WSB1, CBLB,
UBA1, NEDD4, UBA3, DET1, UBE2E2,
RNF111, RNF41
DZIP3, VPRBP, ISG20, CUL3, CDKN2A,
CUL7, APOE, KLHL9, ATG7, FBXO27,
RBCK1, ERAP1, SOCS3, RELA, SOCS1,
UBE2J1, UBR4, UBR2, UBR1, UBE2J2,
ASB9, ASB8, FBXO17, TRIM32, ASB1,
RNF25, ASB3, PIAS1, ASB2, TNFAIP3,
ASB5, ASB4, ASB7, ASB6, ASB12,
UBA6, ASB11, OAS2, CDC34, ASB16,
GO:0044265~cellular macromolecule ASB15, ASB18, ASB17, FBXW7, FBXW8, 1352 4.12426816 7.02E-3 103 7.62962963 3.89E-36 466 725 1.19E-32 1.70E-33 catabolic process ASB10, FBXO6, FBXO44, HECTD3, 8 6 3
FBXO4, TRAF6, FBXO2, MALT1,
UBOX5, TRIM63, P2RX7, CBLB, UBA1,
NEDD4, UBA3, UBE2E2, UBE2G2,
NFKB1, MGRN1, KLHL21, MYC,
KLHL20, UBE2A, GAN, UBE2B, UBE2N,
PJA2, UBE2O, PJA1, KLHL13, NGFR,
OTUD5, UBE2Z, UBE3B, UBE3C,
ZBTB16, TRIM11, UBE2R2, RNF125, CYLD, RNF123, NEDD4L, TRIP12,
RNF144B, LRSAM1, UBE4A, SPSB1,
LRRC41, CBL, SPSB2, SPSB4, PARK2,
UBE2Q1, CISH, WSB1, DET1, RNF111,
RNF41
IL18, STAT5B, TLR1, TLR2, TLR3, TLR4,
NFKB1, TLR7, IL10, TGFB1, TLR8,
TGFB2, TLR9, MAP3K7, MYD88, NOD1,
SAA1, TICAM1, IFNG, IL1B, RARA,
LBP, IL1A, SYK, BCL10, CRTAM, RELA, GO:0001817~regulation of cytokine 4.07407407 1352 7.39E-3 55 4.10E-36 CD40, IFNAR1, CARD11, CD40LG, 466 181 8.82128376 1.25E-32 1.56E-33 production 4 8 3 ASB1, RIPK2, MAVS, TRAF2, TNF,
PANX1, KLRK1, IRAK3, REL, PYCARD,
INPP5D, TRAF6, CD28, IL6, CARD9,
SMAD4, SMAD3, MALT1, FOXP3,
DDX58, P2RX7, IRF1, IRF4, CD14
DZIP3, VPRBP, TGFB1, ISG20, CUL3,
CDKN2A, CUL7, APOE, KLHL9, ATG7,
FBXO27, RBCK1, ERAP1, SOCS3, RELA,
SOCS1, UBE2J1, UBR4, UBR2, UBR1,
GO:0009057~macromolecule catabolic 7.77777777 UBE2J2, ASB9, ASB8, FBXO17, TRIM32, 1352 3.90288669 1.78E-3 105 9.88E-35 466 781 3.01E-31 3.35E-32 process 8 RNF25, ASB1, ASB3, PIAS1, ASB2, 8 2 1
TNFAIP3, ASB5, ASB4, ASB7, ASB6,
ASB12, UBA6, ASB11, OAS2, CDC34,
ASB16, ASB15, ASB18, ASB17, FBXW7,
FBXW8, ASB10, FBXO6, FBXO44, HECTD3, FBXO4, TRAF6, AXIN1,
FBXO2, MALT1, UBOX5, TRIM63,
P2RX7, CBLB, UBA1, NEDD4, UBA3,
UBE2E2, UBE2G2, NFKB1, MGRN1,
KLHL21, MYC, KLHL20, UBE2A, GAN,
UBE2B, UBE2N, PJA2, UBE2O, PJA1,
KLHL13, NGFR, OTUD5, UBE2Z,
UBE3B, UBE3C, ZBTB16, TRIM11,
UBE2R2, RNF125, CYLD, RNF123,
NEDD4L, TRIP12, RNF144B, LRSAM1,
UBE4A, SPSB1, LRRC41, CBL, SPSB2,
SPSB4, PARK2, UBE2Q1, CISH, WSB1,
DET1, RNF111, RNF41
PVR, IL18, STAT5B, TLR2, TLR3, TLR4,
TNFSF12, TLR7, HLA-DMA, TLR8,
TGFB1, TGFB2, MAP3K7, MYD88, IFNG,
TICAM1, IL1B, RARA, LBP, SYK,
IRAK2, IRAK1, BCL10, CRTAM, RELA,
EFNB1, CD40, PDCD1LG2, TRAT1, GO:0002684~positive regulation of 4.44444444 1352 7.31849821 3.50E-3 60 1.94E-34 UBE2N, CARD11, VEGFA, RIPK2, 466 238 5.92E-31 5.92E-32 immune system process 4 8 5 1 CD226, ICOSLG, HLA-DRA, TRAF2,
CD247, KLRK1, NFKBIA, IL7R, VCAM1,
IRAK3, TAP2, IL2RG, INPP5D, TRAF6,
CD28, IL6, IL2RA, IL5, CARD9, IL7,
MALT1, CBLB, P2RX7, CDKN1A, CD19,
IKBKG, IL2 THRA, STAT5B, TLR1, TGFB3, TLR3,
TLR4, TNFSF12, TLR7, TLR8, TGFB1,
IL10, CBFB, TLR9, TGFB2, APOE, ATG7,
IFNG, IL1B, IL1A, SYK, CIITA, BCL10,
IRS2, RARG, RXRA, RELA, CD40, IRS1,
EP300, SIX1, VEGFA, TRIM32, PIAS1,
CAV1, NFKBIA, SOX4, SOX9, FBXO4,
TRAF6, RUNX2, AXIN1, BMP4, BMP2,
MLL, SMAD5, CREBBP, SMAD4,
SMAD3, SMAD2, SMAD1, FOXP3, GH1, GO:0010604~positive regulation of 1352 5.41E-3 108 8 3.00E-33 P2RX7, CBLB, NOTCH1, NEDD4, E2F1, 466 857 3.65839514 9.15E-30 8.32E-31 macromolecule metabolic process 8 0 FOXA2, PAX6, TP63, NFKB1, PAWR,
PAX3, ZEB1, GLI2, GLI3, EDNRB, FOS,
PAX9, TICAM1, MYC, GHR, EGR1,
IRAK1, EGR2, SOX11, TP53, RB1, ESR2,
UBE2N, CARD11, CD81, FOXC1, CSF2,
TNF, PML, KITLG, PRKDC, KIT,
TNFRSF1A, IGF1R, REL, PTK2B,
HAND2, APC, CD28, IL3, IL6, IL5, TBX1,
STAT3, TP73, IRF6, IRF1, PBX1, IRF4,
JAK3, IL2
TBK1, TOLLIP, TLR1, STAT5B, TLR2,
TLR3, NFKB1, TLR4, TLR5, TLR7, TLR8, 6.66666666 1352 4.24829896 4.58E-2 GO:0006952~defense response 90 2.54E-32 IL10, TGFB1, TLR9, TAPBP, FOS, 466 615 7.74E-29 6.45E-30 7 8 4 9 LILRA1, NOD1, MYD88, CD44, SAA1,
GATA3, IL1RAP, IFNG, TICAM1, IL1B, LBP, TNIP1, IL1A, CIITA, IRAK2,
NFKBIZ, BCL10, RXRA, RELA, CD160,
ESR2, CD40, NLRP1, TRAT1, LILRB2,
CCR6, KLRG1, LILRB5, CD40LG,
DEFA5, DEFA4, CCR2, DEFA3, RIPK2,
DEFA1, ICOSLG, PTAFR, KIR3DL2,
HLA-DRA, MAVS, IFIH1, IL1R1, TNF,
NLRX1, CALCOCO2, TNFRSF1A,
TNFRSF1B, DEFA1B, MEFV, TAP2,
TAP1, TBKBP1, BLNK, TYROBP, TLR10,
BMP2, IL6, IL2RA, CARD9, IL5, HCK,
IL1RN, KIR2DS1, MALT1, SMAD1,
AGER, STAT3, TP73, S100A12, DDX58,
P2RX7, CYBB, CD19, IRF7, CD14
IL18, STAT5B, TLR4, ZEB1, TNFSF12,
PAWR, HLA-DMA, IL10, TGFB1,
MAP3K7, CDKN2A, APOE, TICAM1,
IFNG, IL1B, RARA, FAS, LBP, SYK,
BCL10, EFNB1, CD40, PDCD1LG2, 3.70370370 1352 8.29429797 3.96E-2 GO:0050865~regulation of cell activation 50 2.20E-31 CARD11, RIPK2, CD226, ICOSLG, 466 175 6.70E-28 5.16E-29 4 8 7 8 TRAF2, ERBB2, KLRK1, IL7R, VCAM1,
IL2RG, INPP5D, TRAF6, HLA-DOA,
CD28, IL6, IL5, IL2RA, IL7, CTLA4,
MALT1, FOXP3, BTLA, CBLB, CDKN1A,
CD274, IRF4, IL2
GO:0009967~positive regulation of signal 62 4.59259259 8.14E-31 CD8A, FGF9, TBK1, TGFB3, TLR3, TP63, 466 295 1352 6.10122935 2.48E-27 1.77E-28 1.47E-2 transduction 3 FGF10, TLR4, TGFB1, TGFB2, MAP3K7, 8 9 7
MYD88, NOD1, ILK, IFNG, TICAM1,
IL1B, LBP, PRL, SYK, GHR, BCL10,
RELA, CD40, IRS1, TRAT1, UBE2N,
NCAM1, CARD11, TNFRSF10B, RIPK1,
VEGFA, RIPK2, CD226, MAVS, CSF2,
CAV1, TNF, LITAF, ERBB2, SOX4, KIT,
TNFRSF1A, MAP3K3, REL, TRAF6,
AXIN1, BMP4, IL3, IL6, BMP2, IL5,
CARD9, SMAD4, MALT1, TAB2,
CDKN1C, GH1, IKBKE, P2RX7, NEDD4,
IL2
TRAF2, IL18, ERBB2, STAT5B, KLRK1,
PAWR, ZEB1, TNFSF12, IL7R,
HLA-DMA, TGFB1, IL10, MAP3K7,
VCAM1, CDKN2A, IFNG, TICAM1, IL1B,
GO:0051249~regulation of lymphocyte 3.40740740 RARA, IL2RG, INPP5D, FAS, HLA-DOA, 1352 9.02285117 2.37E-2 46 1.32E-30 466 148 4.01E-27 2.67E-28 activation 7 TRAF6, CD28, SYK, BCL10, IL6, IL2RA, 8 7 7
IL5, IL7, EFNB1, CTLA4, MALT1, CD40,
FOXP3, PDCD1LG2, BTLA, CARD11,
CDKN1A, CBLB, CD274, RIPK2, IRF4,
ICOSLG, IL2
TRAF2, IL18, ERBB2, STAT5B, KLRK1,
GO:0002694~regulation of leukocyte 3.55555555 PAWR, ZEB1, TNFSF12, IL7R, 1352 8.39422927 4.06E-2 48 2.25E-30 466 166 6.87E-27 4.29E-28 activation 6 HLA-DMA, TGFB1, IL10, MAP3K7, 8 8 7
VCAM1, CDKN2A, IFNG, TICAM1, IL1B, RARA, IL2RG, INPP5D, LBP, FAS,
HLA-DOA, TRAF6, CD28, SYK, BCL10,
IL6, IL2RA, IL5, IL7, EFNB1, CTLA4,
MALT1, CD40, FOXP3, PDCD1LG2,
BTLA, CARD11, CDKN1A, CBLB,
CD274, RIPK2, IRF4, CD226, ICOSLG,
IL2
E2F1, THRA, FOXA2, TLR1, STAT5B,
TGFB3, PAX6, TLR3, TP63, NFKB1,
TLR4, PAWR, ZEB1, PAX3, GLI2, TLR7,
GLI3, TLR8, IL10, TGFB1, CBFB, TLR9,
TGFB2, FOS, PAX9, APOE, IFNG,
TICAM1, IL1B, MYC, IL1A, SYK, EGR1,
CIITA, EGFR, IRAK1, BCL10, IRS2,
EGR2, RARG, SOX11, RXRA, RELA,
TP53, RB1, ESR2, IRS1, PTHLH, GO:0009891~positive regulation of 6.88888888 1352 3.88459567 4.09E-2 93 2.27E-30 CARD11, EP300, SIX1, VEGFA, FOXC1, 466 695 6.92E-27 4.07E-28 biosynthetic process 9 8 1 7 PIAS1, CSF2, TNF, KLRK1, NFKBIA,
PRKDC, SOX4, KITLG, SOX9,
TNFRSF1A, IGF1R, REL, PTK2B,
HAND2, TRAF6, RUNX2, CD28, BMP4,
IL3, BMP2, IL6, MLL, IL5, CREBBP,
SMAD5, SMAD4, SMAD3, SMAD2,
TBX1, SMAD1, FOXP3, STAT3, TP73,
NOTCH1, IRF6, IRF1, PBX1, IRF4, JAK3,
IL2 PTGS2, STAT5B, TGFB3, TLR2, JAG2,
TLR4, TNFSF12, IL10, TGFB1, TGFB2,
MAP3K7, CUL3, MYD88, CDKN2A,
CD44, ATG5, APOE, ILK, IFNG, IL1B,
FAS, NQO1, IL1A, TWIST2, EGFR,
BCL10, CRTAM, RARG, SOCS3, RXRA,
RELA, MSX1, CD40LG, VEGFA, RIPK2,
TNFAIP3, TRAF1, TRAF2, IFIH1, ERBB2,
NFKBIA, SOX4, SOX9, VDR, TRAF6,
TRAF3, BMP4, CARD9, SMAD3, MALT1, 7.48148148 1352 3.59758814 4.37E-2 GO:0010941~regulation of cell death 101 2.42E-30 TAX1BP1, P2RX7, NOTCH1, CDKN1A, 466 815 7.40E-27 4.11E-28 1 8 1 7 CDKN1B, IKBKG, IKBKB, IFI6, TP63,
NFKB1, PAWR, PTEN, GLI3, EDNRB,
NOD1, TICAM1, MYC, IP6K2, GHR,
IRAK1, TP53, ESR2, NLRP1, CARD11,
SMO, TNFRSF10B, TNFRSF10D, RIPK1,
FOXC1, NGFR, CSF2, TNF, PML,
PRKDC, CDH1, SFN, KIT, ZBTB16,
IGF1R, PYCARD, INPP5D, APC, TXNIP,
IL3, IL6, IL2RA, IL7, STAT1, TP73,
PRLR, IL2
E2F1, THRA, FOXA2, TLR1, STAT5B,
TGFB3, PAX6, TLR3, TP63, NFKB1, GO:0031328~positive regulation of 6.81481481 1352 3.89892547 6.79E-2 92 3.76E-30 TLR4, PAWR, ZEB1, PAX3, GLI2, TLR7, 466 685 1.15E-26 6.04E-28 cellular biosynthetic process 5 8 2 7 GLI3, TLR8, IL10, TGFB1, CBFB, TLR9,
FOS, PAX9, APOE, IFNG, TICAM1, IL1B, MYC, IL1A, SYK, EGR1, CIITA, EGFR,
IRAK1, BCL10, IRS2, EGR2, RARG,
SOX11, RXRA, RELA, TP53, RB1, ESR2,
IRS1, PTHLH, CARD11, EP300, SIX1,
VEGFA, FOXC1, PIAS1, CSF2, TNF,
KLRK1, NFKBIA, SOX4, KITLG,
PRKDC, SOX9, TNFRSF1A, IGF1R, REL,
PTK2B, HAND2, TRAF6, RUNX2, CD28,
BMP4, IL3, BMP2, IL6, MLL, IL5,
CREBBP, SMAD5, SMAD4, SMAD3,
SMAD2, TBX1, SMAD1, FOXP3, STAT3,
TP73, NOTCH1, IRF6, IRF1, PBX1, IRF4,
JAK3, IL2
PTGS2, CD8A, FGF9, TBK1, TGFB3,
TLR3, TP63, FGF10, TLR4, TGFB1,
TGFB2, MAP3K7, MYD88, NOD1, ILK,
IFNG, TICAM1, IL1B, LBP, PRL, SYK,
GHR, EGFR, BCL10, RELA, CD40, IRS1,
TRAT1, UBE2N, NCAM1, CARD11, GO:0010647~positive regulation of cell 4.74074074 1352 5.64718160 1.51E-2 64 8.38E-30 TNFRSF10B, RIPK1, VEGFA, RIPK2, 466 329 2.56E-26 1.28E-27 communication 1 8 1 6 CD226, MAVS, CSF2, CAV1, TNF,
LITAF, ERBB2, SOX4, KIT, TNFRSF1A,
MAP3K3, REL, TRAF6, AXIN1, BMP4,
IL3, IL6, BMP2, IL5, CARD9, SMAD4,
MALT1, TAB2, CDKN1C, GH1, IKBKE,
P2RX7, NEDD4, IL2 PTGS2, STAT5B, TGFB3, TLR2, JAG2,
TLR4, TNFSF12, IL10, TGFB1, TGFB2,
MAP3K7, CUL3, MYD88, CDKN2A,
CD44, ATG5, APOE, ILK, IFNG, IL1B,
FAS, NQO1, IL1A, TWIST2, EGFR,
BCL10, CRTAM, RARG, SOCS3, RXRA,
RELA, MSX1, CD40LG, VEGFA, RIPK2,
TNFAIP3, TRAF1, TRAF2, IFIH1, ERBB2,
SOX4, NFKBIA, SOX9, VDR, TRAF6,
TRAF3, CARD9, SMAD3, MALT1, GO:0043067~regulation of programmed 7.40740740 1352 3.57512843 1.52E-2 100 8.45E-30 TAX1BP1, P2RX7, NOTCH1, CDKN1A, 466 812 2.58E-26 1.23E-27 cell death 7 8 8 6 CDKN1B, IKBKG, IKBKB, IFI6, TP63,
NFKB1, PAWR, PTEN, GLI3, EDNRB,
NOD1, TICAM1, MYC, IP6K2, GHR,
IRAK1, TP53, ESR2, NLRP1, CARD11,
SMO, TNFRSF10B, TNFRSF10D, RIPK1,
FOXC1, NGFR, CSF2, TNF, PML,
PRKDC, CDH1, SFN, KIT, ZBTB16,
IGF1R, PYCARD, INPP5D, APC, TXNIP,
IL3, IL6, IL2RA, IL7, STAT1, TP73,
PRLR, IL2
E2F1, THRA, FOXA2, TLR1, STAT5B,
TGFB3, PAX6, TLR3, TP63, NFKB1, GO:0010557~positive regulation of 6.59259259 1352 2.72E-2 89 1.51E-29 TLR4, PAWR, ZEB1, PAX3, GLI2, TLR7, 466 654 3.95057159 4.60E-26 2.09E-27 macromolecule biosynthetic process 3 8 6 GLI3, TLR8, IL10, TGFB1, CBFB, TLR9,
TGFB2, FOS, PAX9, IFNG, TICAM1, IL1B, MYC, IL1A, SYK, EGR1, CIITA,
IRAK1, BCL10, IRS2, EGR2, RARG,
SOX11, RXRA, RELA, TP53, RB1, ESR2,
IRS1, CARD11, EP300, SIX1, VEGFA,
FOXC1, PIAS1, CSF2, TNF, SOX4,
KITLG, PRKDC, NFKBIA, SOX9,
TNFRSF1A, IGF1R, REL, PTK2B,
HAND2, TRAF6, RUNX2, CD28, BMP4,
IL3, BMP2, IL6, MLL, IL5, CREBBP,
SMAD5, SMAD4, SMAD3, SMAD2,
TBX1, SMAD1, FOXP3, STAT3, TP73,
NOTCH1, IRF6, IRF1, PBX1, IRF4, JAK3,
IL2
PTGS2, STAT5B, TGFB3, TLR2, JAG2,
TLR4, TNFSF12, IL10, TGFB1, TGFB2,
MAP3K7, CUL3, MYD88, CDKN2A,
CD44, ATG5, APOE, ILK, IFNG, IL1B,
FAS, NQO1, IL1A, TWIST2, EGFR,
BCL10, CRTAM, RARG, SOCS3, RXRA, 7.33333333 1352 3.57459483 3.20E-2 GO:0042981~regulation of apoptosis 99 1.77E-29 RELA, MSX1, CD40LG, VEGFA, RIPK2, 466 804 5.41E-26 2.35E-27 3 8 7 6 TNFAIP3, TRAF1, TRAF2, IFIH1, ERBB2,
SOX4, NFKBIA, SOX9, VDR, TRAF6,
TRAF3, CARD9, SMAD3, MALT1,
TAX1BP1, P2RX7, NOTCH1, CDKN1A,
CDKN1B, IKBKG, IKBKB, IFI6, TP63,
NFKB1, PAWR, PTEN, GLI3, EDNRB, NOD1, TICAM1, MYC, IP6K2, GHR,
IRAK1, TP53, ESR2, NLRP1, SMO,
CARD11, TNFRSF10B, TNFRSF10D,
RIPK1, FOXC1, NGFR, CSF2, TNF, PML,
PRKDC, CDH1, SFN, ZBTB16, IGF1R,
PYCARD, INPP5D, APC, TXNIP, IL3, IL6,
IL2RA, IL7, STAT1, TP73, PRLR, IL2
TBK1, TLR1, STAT5B, TLR2, TGFB3,
TLR3, TLR4, TLR5, TLR7, TLR8, IL10,
TLR9, MAP3K7, IFNG, TICAM1, IL1B,
PRL, CHUK, SYK, GHR, EGFR, IRAK2,
IRAK1, BCL10, SOCS3, SOCS1, IRS1,
TANK, IFNAR1, IFNAR2, CRKL,
4.96296296 TNFRSF10B, RIPK1, CD81, CCR2, ROR2, 1352 5.25679155 4.75E-2 GO:0007243~protein kinase cascade 67 2.64E-29 466 370 8.04E-26 3.35E-27 3 PIAS1, ERC1, WNT5A, TRAF2, FGFR1, 8 6 6
CAV1, TNF, NFKBIB, ERBB2, NFKBIA,
KIT, IRAK4, IGF1R, MAP3K3, PTK2B,
TRAF6, TLR10, MALT1, SMAD1, TAB1,
STAT1, AGER, STAT3, STAT2, GH1,
P2RX7, PRLR, IKBKG, IRF3, JAK3,
IKBKB
MAVS, TRAF2, TNF, PANX1, IL18,
KLRK1, TLR2, TLR3, TLR4, TLR7, GO:0001819~positive regulation of 2.66666666 1352 11.6120171 5.65E-2 36 3.13E-28 TGFB1, MAP3K7, MYD88, NOD1, SAA1, 466 90 9.55E-25 3.82E-26 cytokine production 7 8 7 5 TICAM1, IFNG, PYCARD, IL1B, RARA,
LBP, TRAF6, IL1A, BCL10, IL6, CARD9, SMAD3, MALT1, CD40, IFNAR1,
DDX58, CARD11, P2RX7, CD40LG,
RIPK2, CD14
TRAF2, TBK1, NFKBIB, TLR1, TLR2,
NFKBIA, TLR3, TLR4, TLR5, TLR7, IL10,
TLR8, TLR9, IRAK4, MAP3K7, TICAM1, GO:0007249~I-kappaB 2.29629629 1352 14.2846242 2.55E-2 31 1.41E-27 TRAF6, CHUK, IRAK2, IRAK1, BCL10, 466 63 4.31E-24 1.66E-25 kinase/NF-kappaB cascade 6 8 9 4 TLR10, MALT1, STAT1, TANK,
TNFRSF10B, RIPK1, IKBKG, IRF3,
ERC1, IKBKB
TRAF2, IL18, ERBB2, STAT5B, KLRK1,
PAWR, ZEB1, IL7R, HLA-DMA, IL10,
TGFB1, MAP3K7, VCAM1, CDKN2A,
GO:0050863~regulation of T cell 2.88888888 IFNG, IL1B, RARA, IL2RG, HLA-DOA, 1352 9.67668097 6.34E-2 39 3.51E-27 466 117 1.07E-23 3.97E-25 activation 9 TRAF6, CD28, SYK, BCL10, IL6, IL2RA, 8 3 4
IL7, EFNB1, CTLA4, MALT1, FOXP3,
PDCD1LG2, BTLA, CARD11, CBLB,
CD274, RIPK2, IRF4, ICOSLG, IL2
THRA, TBK1, STAT5B, TLR1, TGFB3,
TLR2, TLR3, TLR4, TLR5, TLR7, TLR8,
IL10, TLR9, MAP3K7, CTGF, APOE,
GO:0007242~intracellular signaling 9.03703703 IFNG, IL1B, RAPGEF4, RARA, 1352 2.81979716 9.90E-2 122 5.49E-27 466 1256 1.67E-23 5.98E-25 cascade 7 RAPGEF3, RAPGEF1, SYK, EGFR, 8 2 4
BCL10, RARG, SOCS3, RXRA, SOCS1,
IRS1, TANK, PTHLH, ASB9, ASB8,
CCR2, ASB1, ROR2, ASB3, PIAS1, ASB2, ERC1, ASB5, ASB4, ASB7, ASB6,
WNT5A, FGFR1, TRAF2, CAV1, ERBB2,
NFKBIB, SIPA1, ASB12, NFKBIA,
ASB11, ASB14, ASB16, ASB15, ASB18,
ASB17, IRAK4, VDR, ASB10, FBXO6,
TRAF6, BLNK, TYROBP, TLR10,
SMAD2, MALT1, SMAD1, AGER, GH1,
P2RX7, CBLB, NEDD4, IKBKG, IKBKB,
TOLLIP, TP63, EDNRB, NOD1, TICAM1,
PRL, CHUK, GHR, IRAK2, IRAK1, TP53,
RB1, ESR2, IFNAR1, IFNAR2,
TNFRSF10B, CRKL, RIPK1, CD81,
PTAFR, TNF, PML, SFN, KIT, IGF1R,
MAP3K3, PTK2B, RASGRP1, INPP5D,
SH2B1, NFATC1, SPSB1, SPSB2, SPSB4,
TAB1, STAT1, CISH, STAT3, TP73,
STAT2, WSB1, PRLR, IRF3, JAK3
CD8A, TOLLIP, TLR1, STAT5B, TLR2,
JAG2, TLR3, TLR4, NFKB2, HLA-DMA,
TLR7, IL10, TGFB1, CBFB, SAA1,
TICAM1, FAS, LBP, SYK, EGFR, EGR1, 4.22222222 1352 5.76554859 1.02E-2 GO:0001775~cell activation 57 5.64E-27 CRTAM, RELB, TP53, CD40, IFNAR1, 466 287 1.72E-23 5.93E-25 2 8 4 3 CARD11, ULBP3, CD40LG, ULBP2,
RIPK2, ICOSLG, KIR3DL1, CSF2, TNF,
KLRK1, SOX4, PRKDC, IL7R, VCAM1,
CHD7, TRAF6, APC, CD28, BLNK, IL6, IL7, KIR2DS2, SMAD3, MALT1, FOXP3,
CBLB, P2RX7, PRLR, IRF1, IRF4, IL2
TBK1, FGF9, TLR3, TLR4, PTEN, TGFB1,
TGFB2, MAP3K7, MYD88, NOD1, ILK,
TICAM1, IFNG, IL1B, PRL, SYK, GHR,
BCL10, RELA, SOCS1, CD40, UBE2N,
CARD11, TNFRSF10B, RIPK1, RIPK2, GO:0010627~regulation of protein kinase 3.92592592 1352 2.61E-2 53 1.45E-26 TNFAIP3, MAVS, CSF2, CAV1, TNF, 466 249 6.17908544 4.42E-23 1.47E-24 cascade 6 8 3 LITAF, ERBB2, TNFRSF1A, REL,
MAP3K3, PTK2B, TRAF6, APC, AXIN1,
IL3, IL6, IL5, CARD9, MALT1, TAB2,
TP73, IKBKE, GH1, P2RX7, NEDD4,
IKBKB, IL2
NOG, PTGS2, FGF9, IL18, STAT5B,
PAX6, FGF10, TP63, TNFSF12, PAX3,
GLI2, TGFB1, TGFB2, CUL3,
TNFRSF11A, ILK, IFNG, TICAM1, IL1B,
MYC, PRL, SYK, EGFR, UBE2A, IRS2,
EFNB1, RELA, CD40, IRS1, PDCD1LG2, GO:0008284~positive regulation of cell 4.96296296 1352 4.69809873 4.08E-2 67 2.26E-26 PTHLH, CARD11, SMO, CD81, FOXG1, 466 414 6.89E-23 2.22E-24 proliferation 3 8 3 3 VEGFA, RIPK2, NGFR, ICOSLG, FGFR2,
CSF2, FGFR1, TNF, ERBB2, SOX4,
KITLG, KIT, VCAM1, IGF1R, PTK2B,
CAMK2D, RUNX2, CD28, BMP4, IL3,
IL6, IL2RA, IL5, IL7, STAT1, AGER,
NOTCH1, CDKN1A, CDKN1B, DLX5, PBX1, IL2
CD8A, TOLLIP, TLR1, STAT5B, TLR2,
JAG2, TLR3, TLR4, TLR7, HLA-DMA,
CBFB, TGFB1, IL10, TICAM1, FAS, LBP,
SYK, EGR1, CRTAM, RELB, TP53, CD40,
IFNAR1, CARD11, ULBP3, CD40LG, 3.85185185 1352 6.23786046 5.23E-2 GO:0045321~leukocyte activation 52 2.90E-26 ULBP2, RIPK2, KIR3DL1, ICOSLG, 466 242 8.85E-23 2.77E-24 2 8 2 3 CSF2, KLRK1, SOX4, PRKDC, IL7R,
VCAM1, CHD7, TRAF6, APC, CD28,
BLNK, IL7, KIR2DS2, SMAD3, MALT1,
FOXP3, CBLB, P2RX7, PRLR, IRF1, IRF4,
IL2
MAVS, CSF2, TNF, LITAF, FGF9, TBK1,
ERBB2, TLR3, TLR4, TGFB1, TGFB2,
MAP3K7, TNFRSF1A, MYD88, NOD1,
MAP3K3, REL, ILK, TICAM1, IFNG, GO:0010740~positive regulation of 3.25925925 1352 7.64863406 9.34E-2 44 5.18E-26 IL1B, TRAF6, PRL, AXIN1, GHR, BCL10, 466 167 1.58E-22 4.78E-24 protein kinase cascade 9 8 2 3 IL3, IL6, CARD9, IL5, RELA, MALT1,
CD40, TAB2, UBE2N, CARD11, GH1,
IKBKE, P2RX7, TNFRSF10B, NEDD4,
RIPK1, RIPK2, IL2
TRAF2, IL18, STAT5B, KLRK1, TLR4,
TNFSF12, IL7R, HLA-DMA, TGFB1, GO:0050867~positive regulation of cell 2.66666666 1352 9.41514905 2.28E-2 36 1.26E-24 MAP3K7, VCAM1, TICAM1, IFNG, IL1B, 466 111 3.85E-21 1.13E-22 activation 7 8 5 1 RARA, IL2RG, INPP5D, LBP, TRAF6,
CD28, SYK, BCL10, IL6, IL2RA, IL5, IL7, EFNB1, MALT1, CD40, PDCD1LG2,
CARD11, CDKN1A, RIPK2, CD226,
ICOSLG, IL2
PTGS2, FGF9, IL18, STAT5B, PTGS1,
TLR2, TGFB3, TLR3, TLR4, TLR7,
TGFB1, TGFB2, MAP3K7, MYD88,
NOD1, SAA1, TICAM1, IFNG, IL1B,
RARA, LBP, IL1A, GHR, EGFR, BCL10, GO:0051240~positive regulation of 3.70370370 1352 5.94877928 5.08E-2 50 2.82E-24 CD40, IFNAR1, CARD11, CD40LG, 466 244 8.59E-21 2.46E-22 multicellular organismal process 4 8 7 1 RIPK2, MAVS, TRAF2, CAV1, TNF,
PANX1, KLRK1, CHD7, PYCARD,
TRAF6, BMP4, IL6, BMP2, CARD9,
SMAD3, MALT1, DDX58, GH1, P2RX7,
TNFSF11, CD14
TRAF2, IL18, STAT5B, KLRK1,
TNFSF12, IL7R, HLA-DMA, TGFB1,
MAP3K7, VCAM1, TICAM1, IFNG, IL1B,
GO:0002696~positive regulation of 2.59259259 RARA, IL2RG, INPP5D, LBP, TRAF6, 1352 5.66E-2 35 3.14E-24 466 106 9.58539153 9.57E-21 2.66E-22 leukocyte activation 3 CD28, SYK, BCL10, IL6, IL2RA, IL5, IL7, 8 1
EFNB1, MALT1, CD40, PDCD1LG2,
CARD11, CDKN1A, RIPK2, CD226,
ICOSLG, IL2
E2F1, THRA, FOXA2, STAT5B, TGFB3,
GO:0051173~positive regulation of 5.92592592 PAX6, TP63, NFKB1, TNFSF12, ZEB1, 1352 3.60621651 1.39E-2 80 7.70E-24 466 644 2.35E-20 6.34E-22 nitrogen compound metabolic process 6 PAX3, GLI2, GLI3, IL10, TGFB1, CBFB, 8 2 0
FOS, PAX9, APOE, IFNG, TICAM1, IL1B, MYC, EGR1, CIITA, EGFR, IRAK1,
BCL10, EGR2, RARG, RXRA, RELA,
SOX11, TP53, RB1, ESR2, CD40, UBE2N,
PTHLH, EP300, SIX1, VEGFA, FOXC1,
PIAS1, CSF2, TNF, KLRK1, SOX4,
KITLG, PRKDC, NFKBIA, SOX9,
TNFRSF1A, IGF1R, REL, HAND2,
RUNX2, BMP4, IL3, BMP2, IL6, MLL,
IL5, CREBBP, SMAD5, SMAD4, SMAD3,
SMAD2, TBX1, SMAD1, FOXP3, STAT3,
TP73, NOTCH1, IRF6, IRF1, PBX1, IRF4,
JAK3, IL2
DZIP3, VPRBP, CUL3, CUL7, KLHL9,
ATG7, FBXO27, RBCK1, ERAP1, ERAP2,
SOCS3, RELA, SOCS1, UBE2J1, UBR4,
UBR2, UBR1, UBE2J2, ASB9, ASB8,
FBXO17, TRIM32, RNF25, ASB1, ASB3,
PIAS1, ASB2, TNFAIP3, ASB5, ASB4,
7.77777777 ASB7, ASB6, ASB12, UBA6, ASB11, 1352 2.89198719 1.53E-2 GO:0006508~proteolysis 105 8.46E-24 466 1054 2.58E-20 6.79E-22 8 CDC34, ASB16, ASB15, ASB18, ASB17, 8 8 0
FBXW7, FBXW8, ASB10, FBXO6,
FBXO44, HECTD3, FBXO4, TRAF6,
FBXO2, MALT1, UBOX5, TRIM63,
P2RX7, CBLB, UBA1, NEDD4, UBA3,
UBE2E2, UBE2G2, NFKB1, LNPEP,
MGRN1, TPP2, KLHL21, KLHL20, UBE2A, GAN, CTSS, UBE2B, UBE2N,
PJA2, UBE2O, PJA1, BLMH, KLHL13,
NGFR, OTUD5, UBE2Z, UBE3B, UBE3C,
ZBTB16, TRIM11, UBE2R2, RNF125,
CYLD, RNF123, PRSS2, PYCARD,
NEDD4L, TRIP12, RNF144B, LRSAM1,
UBE4A, SPSB1, LRRC41, CBL, SPSB2,
SPSB4, PARK2, UBE2Q1, CISH, WSB1,
DET1, RNF111, RNF41
IRAK2, IRAK1, BCL10, IL6, TNF, RELA,
TLR2, TLR3, MALT1, TLR4, TGFB1, GO:0051092~positive regulation of 1.77777777 1352 16.9931958 2.53E-2 24 1.40E-23 UBE2N, CARD11, IRAK3, MYD88, 466 41 4.27E-20 1.10E-21 NF-kappaB transcription factor activity 8 8 5 0 RIPK1, TICAM1, PYCARD, RIPK2, IL1B,
EDA, IKBKB, ERC1, CAMK2A
TRAF2, IL18, STAT5B, KLRK1,
TNFSF12, IL7R, HLA-DMA, TGFB1,
VCAM1, MAP3K7, TICAM1, IFNG, IL1B, GO:0051251~positive regulation of 2.44444444 1352 9.87620016 4.80E-2 33 2.66E-23 RARA, IL2RG, INPP5D, TRAF6, CD28, 466 97 8.11E-20 2.03E-21 lymphocyte activation 4 8 8 0 SYK, BCL10, IL6, IL2RA, IL5, IL7,
EFNB1, MALT1, CD40, PDCD1LG2,
CARD11, CDKN1A, RIPK2, ICOSLG, IL2
IL18, ERBB2, STAT5B, PAWR, IL10,
TGFB1, VCAM1, CDKN2A, TICAM1, GO:0050670~regulation of lymphocyte 2.29629629 1352 10.8425461 5.34E-2 31 2.96E-23 IFNG, IL1B, INPP5D, CD28, SYK, IL6, 466 83 9.03E-20 2.20E-21 proliferation 6 8 5 0 IL2RA, IL5, IL7, EFNB1, CTLA4, CD40,
FOXP3, PDCD1LG2, BTLA, CARD11, CDKN1A, CBLB, CD274, RIPK2,
ICOSLG, IL2
PVR, TRAF2, TNF, STAT5B, CD247,
TLR2, KLRK1, NFKBIA, TLR3, FGF10,
TLR4, TLR7, HLA-DMA, TGFB1, TLR8,
TGFB2, MAP3K7, TNFRSF1A, IRAK3,
GO:0048584~positive regulation of 3.55555555 MYD88, NOD1, TAP2, TICAM1, IL1B, 1352 5.90441550 6.67E-2 48 3.70E-23 466 236 1.13E-19 2.68E-21 response to stimulus 6 LBP, TRAF6, AXIN1, SYK, IRAK2, 8 9 0
BCL10, IRAK1, CRTAM, IL6, CARD9,
RELA, SMAD3, MALT1, AGER, IRS1,
UBE2N, P2RX7, CD19, IRF7, VEGFA,
IKBKG, RIPK2, CD226, HLA-DRA
IL18, ERBB2, STAT5B, PAWR, IL10,
TGFB1, VCAM1, CDKN2A, TICAM1,
IFNG, IL1B, INPP5D, CD28, SYK, IL6, GO:0032944~regulation of mononuclear 2.29629629 1352 10.7134682 8.04E-2 31 4.46E-23 IL2RA, IL5, IL7, EFNB1, CTLA4, CD40, 466 84 1.36E-19 3.16E-21 cell proliferation 6 8 2 0 FOXP3, PDCD1LG2, BTLA, CARD11,
CDKN1A, CBLB, CD274, RIPK2,
ICOSLG, IL2
IL18, ERBB2, STAT5B, PAWR, IL10,
TGFB1, VCAM1, CDKN2A, TICAM1,
IFNG, IL1B, INPP5D, CD28, SYK, IL6, GO:0070663~regulation of leukocyte 2.29629629 1352 10.7134682 8.04E-2 31 4.46E-23 IL2RA, IL5, IL7, EFNB1, CTLA4, CD40, 466 84 1.36E-19 3.16E-21 proliferation 6 8 2 0 FOXP3, PDCD1LG2, BTLA, CARD11,
CDKN1A, CBLB, CD274, RIPK2,
ICOSLG, IL2 CD8A, STAT5B, JAG2, FGF10, NFKB2,
HLA-DMA, CBFB, TGFB1, IL10, TGFB2,
TNFRSF11A, FAS, CHUK, SYK, EGR1,
RELB, TP53, RB1, CARD11, CRKL,
GO:0048534~hemopoietic or lymphoid 3.70370370 CD40LG, VEGFA, SIX1, CSF2, TNF, 1352 5.58270056 9.65E-2 50 5.35E-23 466 260 1.63E-19 3.71E-21 organ development 4 PML, KITLG, SOX4, PRKDC, KIT, 8 1 0
ZBTB16, IL7R, VCAM1, CHD7, TRAF6,
CD28, APC, BLNK, BMP4, MLL, IL7,
SMAD5, MALT1, TBX1, TNFSF11, IRF8,
IRF1, PBX1, IRF4, IL2
TNF, TLR2, TLR3, TLR4, IL10, TGFB1,
IRAK3, MYD88, TICAM1, PYCARD,
GO:0051091~positive regulation of IL1B, CAMK2A, IRAK2, IRAK1, BCL10, 1352 13.0635193 1.80E-1 27 2 9.97E-23 466 60 3.04E-19 6.76E-21 transcription factor activity IL6, IL5, RELA, MALT1, UBE2N, 8 1 9
CARD11, EP300, RIPK1, RIPK2, ERC1,
IKBKB, EDA
NOG, PTGS2, PAX6, TGFB3, FGF10,
ZEB1, PAWR, PTEN, GLI3, IL10, TGFB1,
TGFB2, CDKN2A, APOE, ILK, IFNG,
IL1B, IL1A, RARG, RXRA, TP53, RB1,
GO:0008285~negative regulation of cell 4.29629629 ESR2, PDCD1LG2, PTHLH, MSX1, 1352 4.66410661 2.24E-1 58 1.24E-22 466 361 3.79E-19 8.24E-21 proliferation 6 EIF2AK2, CAV1, TNF, STK11, ERBB2, 8 8 9
PML, IFI30, SFN, ZBTB16, VDR, INPP5D,
APC, BMP4, PTPN6, IL6, BMP2, IL2RA,
MLL, CTLA4, SMAD4, SMAD3, SMAD2,
SMAD1, FOXP3, BTLA, CDKN1C, CBLB, CDKN1A, CDKN1B, IRF6, CD274, IL2
FOXA2, FGF9, STAT5B, PAX6, TGFB3,
NFKB1, TNFSF12, GLI2, HLA-DMA,
GLI3, TGFB1, TGFB2, ILK, ERAP1, IL1B,
RARA, IL1A, SYK, SOCS3, RELA, RB1,
SMO, FOXG1, NGFR, CSF2, TNF, GO:0051094~positive regulation of 3.77777777 1352 5.32565535 3.00E-1 51 1.66E-22 TNFRSF12A, KITLG, KIT, IL7R, 466 278 5.06E-19 1.08E-20 developmental process 8 8 6 9 TNFRSF1A, IL2RG, INPP5D, RUNX2,
APC, BMP4, IL6, BMP2, IL5, IL2RA, IL7,
SMAD5, SMAD4, SMAD3, SMAD2,
SMAD1, NOTCH1, P2RX7, TNFSF11,
DLX5, IL2
NOG, THRA, TNF, TLR2, NFKBIA,
TLR3, TLR4, IL10, TGFB1, IRAK3,
MYD88, CDKN2A, TICAM1, PYCARD,
2.88888888 IL1B, CAMK2A, IRAK2, BCL10, IRAK1, 1352 7.39981486 3.05E-1 GO:0051098~regulation of binding 39 1.69E-22 466 153 5.16E-19 1.07E-20 9 IL6, IL5, RELA, SMAD4, SMAD3, 8 2 9
MALT1, SMAD2, FOXP3, UBE2N,
PTHLH, CARD11, SMO, EP300, RIPK1,
RIPK2, PBX1, IRF4, ERC1, EDA, IKBKB
THRA, TNF, TLR2, NFKBIA, TLR3,
TLR4, IL10, TGFB1, IRAK3, MYD88,
GO:0051090~regulation of transcription 2.44444444 CDKN2A, TICAM1, PYCARD, IL1B, 1352 9.30088753 3.93E-1 33 2.18E-22 466 103 6.65E-19 1.36E-20 factor activity 4 CAMK2A, IRAK2, IRAK1, BCL10, IL6, 8 7 9
IL5, RELA, MALT1, FOXP3, UBE2N,
PTHLH, CARD11, EP300, RIPK1, RIPK2, PBX1, ERC1, EDA, IKBKB
THRA, TNF, TLR2, NFKBIA, TLR3,
TLR4, IL10, TGFB1, IRAK3, MYD88,
CDKN2A, TICAM1, PYCARD, IL1B, 2.59259259 1352 8.39711985 7.12E-1 GO:0051101~regulation of DNA binding 35 3.95E-22 CAMK2A, IRAK2, IRAK1, BCL10, IL6, 466 121 1.20E-18 2.41E-20 3 8 2 9 IL5, RELA, MALT1, FOXP3, UBE2N,
PTHLH, CARD11, SMO, EP300, RIPK1,
RIPK2, PBX1, IRF4, ERC1, EDA, IKBKB
E2F1, THRA, FOXA2, STAT5B, PAX6,
TGFB3, TP63, NFKB1, TNFSF12, ZEB1,
PAX3, GLI2, GLI3, IL10, TGFB1, CBFB,
FOS, PAX9, APOE, IFNG, MYC, EGR1,
CIITA, IRAK1, BCL10, EGR2, RARG,
RXRA, RELA, SOX11, TP53, RB1, ESR2,
GO:0045935~positive regulation of CD40, UBE2N, PTHLH, EP300, VEGFA, 1352 3.53571035 7.71E-1 nucleobase, nucleoside, nucleotide and 76 5.62962963 4.28E-22 SIX1, FOXC1, PIAS1, CSF2, TNF, SOX4, 466 624 1.30E-18 2.56E-20 8 5 9 nucleic acid metabolic process KITLG, PRKDC, NFKBIA, SOX9,
TNFRSF1A, IGF1R, REL, HAND2,
RUNX2, BMP4, IL3, BMP2, IL6, MLL,
IL5, SMAD5, CREBBP, SMAD4, SMAD3,
SMAD2, TBX1, SMAD1, FOXP3, STAT3,
TP73, NOTCH1, IRF6, IRF1, PBX1, IRF4,
JAK3, IL2
TNF, TLR2, TLR3, TLR4, IL10, TGFB1, GO:0043388~positive regulation of DNA 2.07407407 1352 11.6120171 1.13E-1 28 6.29E-22 IRAK3, MYD88, TICAM1, PYCARD, 466 70 1.92E-18 3.69E-20 binding 4 8 7 8 IL1B, CAMK2A, IRAK2, IRAK1, BCL10, IL6, IL5, RELA, MALT1, UBE2N,
CARD11, EP300, RIPK1, RIPK2, IRF4,
ERC1, IKBKB, EDA
CD8A, STAT5B, JAG2, FGF10, NFKB2,
HLA-DMA, CBFB, TGFB1, IL10, TGFB2,
TNFRSF11A, FAS, CHUK, SYK, EGR1,
RELB, TP53, RB1, CARD11, CRKL,
GO:0002520~immune system 3.70370370 CD40LG, VEGFA, SIX1, CSF2, TNF, 1352 5.25906574 1.46E-1 50 8.08E-22 466 276 2.47E-18 4.65E-20 development 4 PML, KITLG, SOX4, PRKDC, KIT, 8 6 8
ZBTB16, IL7R, VCAM1, CHD7, TRAF6,
CD28, APC, BLNK, BMP4, MLL, IL7,
SMAD5, MALT1, TBX1, TNFSF11, IRF8,
IRF1, PBX1, IRF4, IL2
TOLLIP, STAT5B, TLR1, TLR2, TLR3,
TLR4, NFKB1, TLR5, TLR7, IL10,
TGFB1, TLR8, TLR9, FOS, MYD88,
NOD1, CD44, SAA1, IL1RAP, TICAM1,
IL1B, LBP, IL1A, IRAK2, CIITA, 1352 4.82345328 1.68E-1 GO:0006954~inflammatory response 54 4 9.31E-22 NFKBIZ, RXRA, RELA, CD40, KLRG1, 466 325 2.84E-18 5.26E-20 8 5 8 CD40LG, CCR2, RIPK2, PTAFR, TNF,
TNFRSF1A, TNFRSF1B, MEFV, BLNK,
IL6, BMP2, TLR10, IL2RA, IL5, IL1RN,
SMAD1, AGER, TP73, STAT3, S100A12,
CYBB, P2RX7, IRF7, CD14
3.11111111 CD8A, STAT5B, JAG2, KLRK1, PRKDC, 1352 6.12694373 1.19E-1 GO:0046649~lymphocyte activation 42 6.62E-21 466 199 2.02E-17 3.67E-19 1 SOX4, IL7R, HLA-DMA, CBFB, TGFB1, 8 2 7 IL10, VCAM1, CHD7, FAS, CD28, BLNK,
SYK, APC, EGR1, CRTAM, IL7, RELB,
KIR2DS2, TP53, SMAD3, MALT1, CD40,
FOXP3, IFNAR1, CARD11, P2RX7,
CBLB, PRLR, ULBP3, CD40LG, ULBP2,
IRF1, RIPK2, IRF4, KIR3DL1, ICOSLG,
IL2
THRA, PTGS2, PTGS1, STAT5B, TGFB3,
TLR2, TLR3, TLR4, PTEN, IL10, TGFB1,
TGFB2, FOS, MYD88, CD44, APOE,
GATA3, IFNG, TICAM1, IL1B, RARA,
FAS, LBP, MYC, GHR, EGR1, CIITA,
IRAK2, EGFR, IRAK1, BCL10, IRS2,
EGR2, SOCS3, RXRA, RELA, SOCS1,
ESR2, IRS1, UBE2B, MSX1, EP300, GO:0010033~response to organic 5.92592592 1352 3.22108659 1.73E-1 80 9.58E-21 RIPK1, RYR1, RIPK2, COL1A1, 466 721 2.92E-17 5.22E-19 substance 6 8 3 7 EIF2AK2, PTAFR, IL1R1, CAV1, TNF,
PANX1, ERBB2, PML, CALCOCO2,
PRKDC, NFKBIA, CDH1, IRAK3,
TNFRSF1A, IGF1R, PTK2B, TAP2, BMP4,
TXNIP, IL6, CARD9, IL1RN, SMAD3,
SMAD2, MALT1, SMAD1, STAT1,
STAT3, GH1, CDKN1A, P2RX7, IRF3,
PTPN1, CD14
GO:0045893~positive regulation of 4.74074074 E2F1, THRA, FOXA2, STAT5B, PAX6, 1352 3.89501624 1.74E-1 64 9.65E-21 466 477 2.94E-17 5.16E-19 transcription, DNA-dependent 1 TGFB3, TP63, NFKB1, ZEB1, PAX3, 8 1 7 GLI2, CBFB, IL10, TGFB1, FOS, PAX9,
IFNG, MYC, EGR1, CIITA, BCL10, EGR2,
RARG, RXRA, RELA, SOX11, TP53, RB1,
ESR2, EP300, VEGFA, SIX1, FOXC1,
PIAS1, TNF, SOX4, PRKDC, NFKBIA,
SOX9, TNFRSF1A, REL, HAND2,
RUNX2, BMP4, IL6, BMP2, IL5, MLL,
SMAD5, CREBBP, SMAD4, SMAD3,
SMAD2, TBX1, SMAD1, FOXP3, STAT3,
TP73, NOTCH1, IRF1, PBX1, JAK3, IRF4,
IL2
E2F1, THRA, FOXA2, STAT5B, PAX6,
TGFB3, TP63, NFKB1, ZEB1, PAX3,
GLI2, CBFB, IL10, TGFB1, FOS, PAX9,
IFNG, MYC, EGR1, CIITA, BCL10, EGR2,
RARG, RXRA, RELA, SOX11, TP53, RB1,
ESR2, EP300, VEGFA, SIX1, FOXC1, GO:0051254~positive regulation of RNA 4.74074074 1352 3.86262525 2.70E-1 64 1.50E-20 PIAS1, TNF, SOX4, PRKDC, NFKBIA, 466 481 4.56E-17 7.87E-19 metabolic process 1 8 3 7 SOX9, TNFRSF1A, REL, HAND2,
RUNX2, BMP4, IL6, BMP2, IL5, MLL,
SMAD5, CREBBP, SMAD4, SMAD3,
SMAD2, TBX1, SMAD1, FOXP3, STAT3,
TP73, NOTCH1, IRF1, PBX1, JAK3, IRF4,
IL2
GO:0045944~positive regulation of 4.14814814 E2F1, THRA, FOXA2, STAT5B, PAX6, 1352 4.38189327 2.76E-1 56 1.53E-20 466 371 4.66E-17 7.91E-19 transcription from RNA polymerase II 8 TGFB3, TP63, NFKB1, PAX3, ZEB1, 8 1 7 promoter GLI2, CBFB, TGFB1, FOS, PAX9, MYC,
CIITA, EGR1, EGR2, RARG, RELA,
RXRA, SOX11, TP53, RB1, ESR2, EP300,
VEGFA, SIX1, FOXC1, TNF, PRKDC,
NFKBIA, SOX9, TNFRSF1A, HAND2,
RUNX2, BMP4, IL6, BMP2, MLL,
SMAD5, CREBBP, SMAD4, SMAD3,
TBX1, SMAD2, SMAD1, FOXP3, STAT3,
NOTCH1, IRF1, PBX1, JAK3, IRF4, IL2
MAVS, TNF, PTGS2, STAT5B, TLR2,
NFKBIA, TLR3, TLR4, IL10, TLR9,
TNFRSF1A, FOS, IRAK3, MYD88,
DEFA1B, NOD1, TAP2, TICAM1, IFNG, 3.03703703 1352 6.16700393 2.90E-1 GO:0009617~response to bacterium 41 1.61E-20 IL1B, ERAP1, LBP, BCL10, IRAK1, IL6, 466 193 4.90E-17 8.17E-19 7 8 6 7 CARD9, SOCS3, RELA, HCK, SOCS1,
MALT1, STAT1, S100A12, P2RX7,
DEFA5, DEFA4, DEFA3, RIPK2, DEFA1,
IRF3, CD14, PTAFR
STAT5B, TGFB3, TP63, NFKB1, PTEN,
IL10, MAP3K7, EDNRB, MYD88, ATG5,
APOE, ILK, IL1B, FAS, MYC, TWIST2,
GO:0043069~negative regulation of 4.07407407 IL1A, EGFR, BCL10, IRAK1, SOCS3, 1352 4.44749961 3.19E-1 55 1.77E-20 466 359 5.39E-17 8.84E-19 programmed cell death 4 RELA, TP53, ESR2, SMO, MSX1, 8 1 7
TNFRSF10D, CD40LG, VEGFA, RIPK2,
FOXC1, NGFR, TNFAIP3, CSF2, TNF,
ERBB2, SOX4, NFKBIA, KIT, IGF1R, TRAF6, APC, IL3, IL6, IL7, SMAD3,
MALT1, TP73, TAX1BP1, NOTCH1,
CDKN1A, PRLR, IKBKB, IFI6, IL2
TNF, TLR2, TLR3, TLR4, IL10, TGFB1,
IRAK3, MYD88, TICAM1, PYCARD,
GO:0051099~positive regulation of 2.07407407 IL1B, CAMK2A, IRAK2, IRAK1, BCL10, 1352 10.4210410 3.20E-1 28 1.78E-20 466 78 5.42E-17 8.74E-19 binding 4 IL6, IL5, RELA, MALT1, UBE2N, 8 5 7
CARD11, EP300, RIPK1, RIPK2, IRF4,
ERC1, IKBKB, EDA
MAVS, PVR, TRAF2, TNF, STAT5B,
KLRK1, PML, TNFSF12, IL7R, IL10,
GO:0002697~regulation of immune 2.29629629 TGFB1, MAP3K7, IRAK3, TAP2, IFNG, 1352 8.91021119 3.55E-1 31 1.97E-20 466 101 6.00E-17 9.52E-19 effector process 6 IL1B, LBP, TRAF6, CD28, SYK, BCL10, 8 3 7
IL6, CRTAM, MALT1, CD40, FOXP3,
DDX58, P2RX7, CD40LG, CD226, IL2
STAT5B, TGFB3, TP63, NFKB1, PTEN,
IL10, MAP3K7, EDNRB, MYD88, ATG5,
APOE, ILK, IL1B, FAS, MYC, TWIST2,
IL1A, EGFR, BCL10, IRAK1, SOCS3,
RELA, TP53, ESR2, SMO, MSX1, GO:0060548~negative regulation of cell 4.07407407 1352 4.43514544 3.63E-1 55 2.01E-20 TNFRSF10D, CD40LG, VEGFA, RIPK2, 466 360 6.15E-17 9.60E-19 death 4 8 6 7 FOXC1, NGFR, TNFAIP3, CSF2, TNF,
ERBB2, SOX4, NFKBIA, KIT, IGF1R,
TRAF6, APC, IL3, IL6, IL7, SMAD3,
MALT1, TP73, TAX1BP1, NOTCH1,
CDKN1A, PRLR, IKBKB, IFI6, IL2 PVR, TRAF2, CD247, STAT5B, KLRK1,
TLR2, NFKBIA, TLR3, TLR4, HLA-DMA,
TLR7, TLR8, TGFB2, MAP3K7, IRAK3,
GO:0050778~positive regulation of 2.66666666 MYD88, TAP2, TICAM1, IL1B, LBP, 1352 7.20745893 4.07E-1 36 2.26E-20 466 145 6.89E-17 1.06E-18 immune response 7 TRAF6, SYK, IRAK2, BCL10, IRAK1, 8 1 7
CRTAM, CARD9, RELA, MALT1,
UBE2N, P2RX7, CD19, IKBKG, RIPK2,
CD226, HLA-DRA
E2F1, THRA, FOXA2, STAT5B, PAX6,
TGFB3, TP63, NFKB1, ZEB1, PAX3,
GLI2, GLI3, IL10, TGFB1, CBFB, FOS,
PAX9, IFNG, MYC, EGR1, CIITA, IRAK1,
BCL10, EGR2, RARG, RXRA, RELA,
SOX11, TP53, RB1, ESR2, EP300,
GO:0010628~positive regulation of gene 5.18518518 VEGFA, SIX1, FOXC1, PIAS1, CSF2, 1352 3.49759553 8.31E-1 70 4.60E-20 466 581 1.40E-16 2.13E-18 expression 5 TNF, SOX4, PRKDC, NFKBIA, KIT, 8 2 7
SOX9, TNFRSF1A, REL, HAND2,
RUNX2, BMP4, IL3, BMP2, IL6, IL5,
MLL, SMAD5, CREBBP, SMAD4,
SMAD3, SMAD2, TBX1, SMAD1, FOXP3,
STAT3, TP73, NOTCH1, IRF6, IRF1,
PBX1, JAK3, IRF4, IL2
STAT5B, TGFB3, TP63, NFKB1, PTEN,
GO:0043066~negative regulation of IL10, MAP3K7, EDNRB, MYD88, ATG5, 1352 4.42831163 9.15E-1 54 4 5.07E-20 466 354 1.55E-16 2.31E-18 apoptosis APOE, ILK, IL1B, FAS, MYC, TWIST2, 8 2 7
IL1A, EGFR, BCL10, IRAK1, SOCS3, RELA, TP53, ESR2, SMO, MSX1,
TNFRSF10D, CD40LG, VEGFA, RIPK2,
FOXC1, NGFR, TNFAIP3, CSF2, TNF,
ERBB2, SOX4, NFKBIA, IGF1R, TRAF6,
APC, IL3, IL6, IL7, SMAD3, MALT1,
TP73, TAX1BP1, NOTCH1, CDKN1A,
PRLR, IKBKB, IFI6, IL2
TNF, TLR1, STAT5B, TLR3, TLR4, TLR7,
TLR8, IL10, TLR9, REL, TICAM1, IFNG, GO:0042035~regulation of cytokine 1352 10.5920426 1.07E-1 27 2 5.92E-20 IL1B, INPP5D, TRAF6, IL1A, SYK, CD28, 466 74 1.81E-16 2.66E-18 biosynthetic process 8 9 6 BCL10, IL6, CARD9, RELA, FOXP3,
CARD11, ASB1, IRF1, IRF4
CSF2, TNF, CD8A, STAT5B, JAG2, PML,
PRKDC, KITLG, SOX4, ZBTB16, KIT,
IL7R, HLA-DMA, CBFB, TGFB1, IL10,
TGFB2, VCAM1, CHD7, FAS, TRAF6, 3.25925925 1352 5.41238088 1.86E-1 GO:0030097~hemopoiesis 44 1.03E-19 CHUK, CD28, APC, BLNK, SYK, BMP4, 466 236 3.15E-16 4.57E-18 9 8 3 6 EGR1, MLL, IL7, RELB, SMAD5, TP53,
MALT1, RB1, CARD11, TNFSF11,
CD40LG, VEGFA, IRF8, IRF1, PBX1,
IRF4, IL2
IL18, ERBB2, STAT5B, PAWR, IL10,
TGFB1, VCAM1, CDKN2A, IFNG, IL1B, GO:0042129~regulation of T cell 1.85185185 1352 11.7056624 2.04E-1 25 1.13E-19 SYK, CD28, IL6, IL2RA, EFNB1, CTLA4, 466 62 3.45E-16 4.93E-18 proliferation 2 8 7 6 FOXP3, PDCD1LG2, BTLA, CARD11,
CBLB, CD274, RIPK2, ICOSLG, IL2 NOG, FOXA2, TOLLIP, TLR1, STAT5B,
TLR2, TGFB3, TLR3, FGF10, NFKB1,
TLR4, TLR5, TLR7, TLR8, IL10, TGFB1,
TLR9, TGFB2, FOS, MYD88, NOD1,
CD44, CTGF, SAA1, IL1RAP, TICAM1,
IL1B, LBP, IL1A, IRAK2, CIITA,
4.88888888 NFKBIZ, RXRA, RELA, CD40, SMO, 1352 3.61506194 2.10E-1 GO:0009611~response to wounding 66 1.16E-19 466 530 3.54E-16 4.99E-18 9 KLRG1, CD40LG, CCR2, RIPK2, NGFR, 8 8 6
PTAFR, TNF, ERBB2, TNFRSF1A,
TNFRSF1B, MEFV, BLNK, PTPN6, IL6,
BMP2, TLR10, IL2RA, IL5, IL1RN,
SMAD3, SMAD1, AGER, STAT3, TP73,
S100A12, CYBB, NOTCH1, P2RX7, IRF7,
CD14
IRAK2, IRAK1, BCL10, RELA, CD247,
KLRK1, TLR2, NFKBIA, TLR3, MALT1, GO:0002764~immune 1.77777777 1352 12.4414469 2.40E-1 24 1.33E-19 TLR4, CD40, TLR7, UBE2N, BTLA, 466 56 4.06E-16 5.64E-18 response-regulating signal transduction 8 8 7 6 MAP3K7, IRAK3, CD19, MYD88,
TICAM1, IKBKG, RIPK2, TRAF6, SYK
CSF2, FOXA2, TNFRSF12A, STAT5B,
PAX6, TGFB3, KITLG, NFKB1, KIT,
IL7R, GLI2, GLI3, HLA-DMA, TGFB1, GO:0045597~positive regulation of cell 3.18518518 1352 5.45105609 3.92E-1 43 2.17E-19 TGFB2, ILK, RARA, IL2RG, INPP5D, 466 229 6.63E-16 9.08E-18 differentiation 5 8 4 6 RUNX2, SYK, APC, BMP4, BMP2, IL6,
IL2RA, IL5, IL7, SOCS3, RELA, SMAD5,
SMAD4, SMAD3, SMAD2, RB1, SMAD1, SMO, NOTCH1, TNFSF11, DLX5,
FOXG1, NGFR, IL2
PTGS2, STAT5B, TLR2, NFKBIA, TLR4,
IL10, FOS, IRAK3, TNFRSF1A, MYD88,
GO:0002237~response to molecule of 2.07407407 TAP2, TICAM1, IL1B, LBP, IRAK1, 1352 5.88E-1 28 3.26E-19 466 86 9.45164188 9.95E-16 1.34E-17 bacterial origin 4 BCL10, IL6, CARD9, SOCS3, RELA, 8 6
SOCS1, MALT1, STAT1, P2RX7, RIPK2,
IRF3, CD14, PTAFR
CSF2, TNF, CD8A, STAT5B, JAG2,
PRKDC, SOX4, KIT, IL7R, HLA-DMA,
IL10, TGFB1, CBFB, VCAM1, CHD7, 2.44444444 1352 7.31291157 1.22E-1 GO:0002521~leukocyte differentiation 33 6.78E-19 FAS, TRAF6, CHUK, CD28, BLNK, SYK, 466 131 2.07E-15 2.76E-17 4 8 5 5 APC, EGR1, IL7, RELB, TP53, MALT1,
CARD11, TNFSF11, CD40LG, IRF1, IRF4,
IL2
E2F1, THRA, FOXA2, STAT5B, PAX6,
TGFB3, TP63, NFKB1, ZEB1, PAX3,
GLI2, GLI3, CBFB, IL10, TGFB1, FOS,
PAX9, IFNG, MYC, EGR1, CIITA, IRAK1,
BCL10, EGR2, RARG, RXRA, RELA, GO:0045941~positive regulation of 4.96296296 1352 3.44860438 1.28E-1 67 7.10E-19 SOX11, TP53, RB1, ESR2, EP300, 466 564 2.17E-15 2.85E-17 transcription 3 8 9 5 VEGFA, SIX1, FOXC1, PIAS1, TNF,
SOX4, PRKDC, NFKBIA, SOX9,
TNFRSF1A, REL, HAND2, RUNX2,
BMP4, BMP2, IL6, IL5, MLL, SMAD5,
CREBBP, SMAD4, SMAD3, SMAD2, TBX1, SMAD1, FOXP3, STAT3, TP73,
NOTCH1, IRF6, IRF1, PBX1, JAK3, IRF4,
IL2
TRAF2, IL18, STAT5B, KLRK1, IL7R,
HLA-DMA, VCAM1, MAP3K7, IFNG,
GO:0050870~positive regulation of T cell 1.92592592 IL1B, RARA, IL2RG, TRAF6, SYK, CD28, 1352 9.93133047 3.51E-1 26 1.94E-18 466 76 5.93E-15 7.70E-17 activation 6 BCL10, IL6, IL2RA, IL7, EFNB1, MALT1, 8 2 5
PDCD1LG2, CARD11, RIPK2, ICOSLG,
IL2
PTGS2, TLR2, TGFB3, TP63, TLR4,
PAWR, TNFSF12, PTEN, IL10, TGFB1,
TGFB2, CUL3, CDKN2A, NOD1, CD44,
APOE, IFNG, TICAM1, IL1B, FAS,
NQO1, MYC, IP6K2, BCL10, CRTAM,
GO:0010942~positive regulation of cell 4.22222222 RARG, RXRA, TP53, NLRP1, 1352 3.80393665 9.61E-1 57 5.33E-18 466 435 1.62E-14 2.08E-16 death 2 TNFRSF10B, RIPK1, RIPK2, NGFR, 8 8 5
TRAF2, TNF, PML, SOX4, PRKDC, SFN,
ZBTB16, VDR, PYCARD, INPP5D,
TRAF6, APC, TRAF3, BMP4, TXNIP,
IL2RA, SMAD3, STAT1, TP73, NOTCH1,
P2RX7, CDKN1A, CDKN1B, IKBKG
IRAK2, IRAK1, BCL10, RELA, CD247,
KLRK1, TLR2, NFKBIA, TLR3, MALT1, GO:0002757~immune 1352 12.2819412 1.44E-1 22 1.62962963 7.96E-18 TLR4, TLR7, UBE2N, MAP3K7, IRAK3, 466 52 2.43E-14 3.07E-16 response-activating signal transduction 8 3 4 CD19, MYD88, TICAM1, IKBKG, RIPK2,
TRAF6, SYK PVR, IRAK2, IRAK1, BCL10, CRTAM,
CARD9, RELA, STAT5B, KLRK1, TLR2, GO:0045089~positive regulation of 1.55555555 1352 13.2528456 1.50E-1 21 8.33E-18 NFKBIA, TLR3, TLR4, TLR7, TLR8, 466 46 2.54E-14 3.18E-16 innate immune response 6 8 8 4 IRAK3, MYD88, TICAM1, RIPK2, LBP,
CD226
PTGS2, TLR2, TGFB3, TP63, TLR4,
PAWR, TNFSF12, PTEN, TGFB1, IL10,
TGFB2, CUL3, CDKN2A, NOD1, CD44,
APOE, IFNG, TICAM1, IL1B, FAS,
NQO1, MYC, IP6K2, BCL10, CRTAM,
GO:0043065~positive regulation of 4.14814814 RARG, RXRA, TP53, NLRP1, 1352 3.78065675 2.60E-1 56 1.44E-17 466 430 4.40E-14 5.44E-16 apoptosis 8 TNFRSF10B, RIPK1, RIPK2, NGFR, 8 2 4
TRAF2, TNF, PML, SOX4, PRKDC, SFN,
ZBTB16, VDR, PYCARD, INPP5D,
TRAF6, APC, TRAF3, TXNIP, IL2RA,
SMAD3, STAT1, TP73, NOTCH1, P2RX7,
CDKN1A, CDKN1B, IKBKG
MAVS, TNF, LITAF, TBK1, TLR3, TLR4,
MAP3K7, TNFRSF1A, NOD1, MYD88,
REL, MAP3K3, TICAM1, IL1B, TRAF6, GO:0043122~regulation of I-kappaB 2.14814814 1352 7.86795555 2.77E-1 29 1.54E-17 BCL10, CARD9, RELA, MALT1, CD40, 466 107 4.69E-14 5.72E-16 kinase/NF-kappaB cascade 8 8 7 4 TAB2, UBE2N, IKBKE, CARD11,
TNFRSF10B, RIPK1, RIPK2, TNFAIP3,
IKBKB
GO:0032675~regulation of interleukin-6 1.40740740 IL6, CARD9, TNF, TLR1, TLR2, TLR3, 1352 15.3214115 2.90E-1 19 1.61E-17 466 36 4.91E-14 5.92E-16 production 7 TLR4, TLR7, IL10, IRAK3, P2RX7, 8 4 4 NOD1, TICAM1, IFNG, RIPK2, IL1B,
INPP5D, LBP, TRAF6
CD8A, STAT5B, JAG2, PRKDC, SOX4,
IL7R, HLA-DMA, TGFB1, CHD7, FAS,
2.29629629 SYK, APC, CD28, EGR1, CRTAM, IL7, 1352 7.14231214 3.36E-1 GO:0042110~T cell activation 31 1.86E-17 466 126 5.68E-14 6.76E-16 6 RELB, TP53, SMAD3, MALT1, FOXP3, 8 7 4
IFNAR1, CARD11, P2RX7, CBLB, PRLR,
IRF1, RIPK2, IRF4, ICOSLG, IL2
PTGS2, TLR2, TGFB3, TP63, TLR4,
PAWR, TNFSF12, PTEN, TGFB1, IL10,
TGFB2, CUL3, CDKN2A, NOD1, CD44,
APOE, IFNG, TICAM1, IL1B, FAS,
NQO1, MYC, IP6K2, BCL10, CRTAM,
GO:0043068~positive regulation of 4.14814814 RARG, RXRA, TP53, NLRP1, 1352 3.75446282 3.56E-1 56 1.97E-17 466 433 6.02E-14 7.08E-16 programmed cell death 8 TNFRSF10B, RIPK1, RIPK2, NGFR, 8 5 4
TRAF2, TNF, PML, SOX4, PRKDC, SFN,
ZBTB16, VDR, PYCARD, INPP5D,
TRAF6, APC, TRAF3, TXNIP, IL2RA,
SMAD3, STAT1, TP73, NOTCH1, P2RX7,
CDKN1A, CDKN1B, IKBKG
PVR, IRAK2, IRAK1, BCL10, CRTAM,
CARD9, RELA, STAT5B, KLRK1, TLR2, GO:0045088~regulation of innate 1352 11.8270545 3.64E-1 22 1.62962963 2.02E-17 NFKBIA, TLR3, TLR4, TLR7, TLR8, 466 54 6.16E-14 7.16E-16 immune response 8 2 4 IRAK3, MYD88, TICAM1, ERAP1,
RIPK2, LBP, CD226
GO:0042108~positive regulation of 21 1.55555555 2.32E-17 BCL10, TNF, RELA, STAT5B, TLR1, 466 48 1352 12.7006437 7.09E-14 8.15E-16 4.19E-1 cytokine biosynthetic process 6 TLR3, TLR4, TLR7, TLR8, TLR9, 8 8 4
CARD11, REL, TICAM1, IFNG, IRF1,
IL1B, IRF4, TRAF6, IL1A, CD28, SYK
MAVS, IFIH1, TNF, TBK1, TLR3, TLR7,
IFI35, TLR8, ISG20, TLR9, IRAK3,
2.14814814 DEFA1B, TICAM1, IFNG, IFNGR2, 1352 4.71E-1 GO:0009615~response to virus 29 2.61E-17 466 109 7.7235894 7.97E-14 9.06E-16 8 IFNGR1, IL6, CARD9, RELA, STAT1, 8 4
IFNAR1, STAT2, IRF9, DDX58, IFNAR2,
IRF7, DEFA3, DEFA1, IRF3, EIF2AK2
TGFB3, TLR3, TLR4, PTEN, TGFB1,
TGFB2, MAP3K7, EDNRB, CDKN2A,
APOE, ILK, IFNG, IL1B, RAPGEF4,
RAPGEF3, SYK, GHR, EGFR, IRAK1,
BCL10, SOCS3, SOCS1, RB1, IRS1,
GO:0042325~regulation of 4.29629629 TNFRSF10B, RIPK1, CD81, CSF2, 1352 3.61318130 5.09E-1 58 2.82E-17 466 466 8.61E-14 9.68E-16 phosphorylation 6 TRAF2, CAV1, TNF, ERBB2, KITLG, 8 7 4
KIT, SFN, IRAK3, PTK2B, TRAF6,
AXIN1, APC, BMP4, IL3, IL6, BMP2, IL5,
SMAD4, MALT1, TAB1, CISH, TP73,
CDKN1C, GH1, P2RX7, CDKN1A,
CDKN1B, PRLR, IKBKG, IL2
TGFB3, TLR3, TLR4, PTEN, TGFB1,
TGFB2, MAP3K7, EDNRB, CDKN2A, GO:0051174~regulation of phosphorus 1352 3.53148975 7.50E-1 59 4.37037037 4.15E-17 APOE, ILK, IFNG, IL1B, RAPGEF4, 466 485 1.27E-13 1.41E-15 metabolic process 8 7 4 RAPGEF3, SYK, GHR, EGFR, IRAK1,
BCL10, SOCS3, SOCS1, RB1, IRS1, TNFRSF10B, RIPK1, CD81, CSF2,
TRAF2, CAV1, TNF, ERBB2, KITLG,
KIT, SFN, IRAK3, PTK2B, TRAF6,
AXIN1, APC, BMP4, IL3, IL6, BMP2, IL5,
SMAD4, SMAD3, MALT1, TAB1, CISH,
TP73, CDKN1C, GH1, P2RX7, CDKN1A,
CDKN1B, PRLR, IKBKG, IL2
TGFB3, TLR3, TLR4, PTEN, TGFB1,
TGFB2, MAP3K7, EDNRB, CDKN2A,
APOE, ILK, IFNG, IL1B, RAPGEF4,
RAPGEF3, SYK, GHR, EGFR, IRAK1,
BCL10, SOCS3, SOCS1, RB1, IRS1,
GO:0019220~regulation of phosphate TNFRSF10B, RIPK1, CD81, CSF2, 1352 3.53148975 7.50E-1 59 4.37037037 4.15E-17 466 485 1.27E-13 1.41E-15 metabolic process TRAF2, CAV1, TNF, ERBB2, KITLG, 8 7 4
KIT, SFN, IRAK3, PTK2B, TRAF6,
AXIN1, APC, BMP4, IL3, IL6, BMP2, IL5,
SMAD4, SMAD3, MALT1, TAB1, CISH,
TP73, CDKN1C, GH1, P2RX7, CDKN1A,
CDKN1B, PRLR, IKBKG, IL2
TLR2, TGFB3, TLR3, TLR4, IL10, TGFB1,
TGFB2, MAP3K7, EDNRB, CDKN2A,
MYD88, NOD1, APOE, ILK, IFNG, GO:0044093~positive regulation of 4.81481481 1352 3.22005595 2.00E-1 65 8.05E-17 TICAM1, IL1B, MYC, SYK, GHR, EGFR, 466 586 3.39E-13 3.77E-15 molecular function 5 8 5 3 IRAK2, IRAK1, BCL10, RELA, TP53,
IRS1, NLRP1, UBE2N, PTHLH, CARD11,
EP300, TNFRSF10B, RIPK1, CD81, RIPK2, EDA, ERC1, TRAF2, CAV1, TNF,
ERBB2, PML, KITLG, KIT, IRAK3, VDR,
PTK2B, PYCARD, TRAF6, CAMK2A,
IL6, IL5, SMAD3, MALT1, TAB1, STAT1,
CISH, GH1, P2RX7, PRLR, IKBKG, IRF4,
IKBKB, IL2
TNF, PANX1, NFKBIE, NFKBIB, TGFB3,
NFKBIA, CDH1, GLI3, IL10, TGFB1,
GO:0051223~regulation of protein 2.14814814 TGFB2, SAA1, IFNG, PYCARD, IL1B, 1352 7.38483547 2.00E-1 29 9.33E-17 466 114 3.39E-13 3.66E-15 transport 8 TRAF6, IL1A, BMP4, IL6, CRTAM, 8 9 3
SMAD4, SMAD3, CD40, FOXP3, SMO,
P2RX7, CD40LG, EDA, IL2
MAVS, TNF, LITAF, TBK1, TLR3, TLR4,
MAP3K7, TNFRSF1A, NOD1, MYD88,
GO:0043123~positive regulation of REL, MAP3K3, TICAM1, IL1B, TRAF6, 1352 2.00E-1 27 2 1.17E-16 466 97 8.08052741 3.39E-13 3.66E-15 I-kappaB kinase/NF-kappaB cascade BCL10, CARD9, RELA, MALT1, CD40, 8 3
TAB2, UBE2N, IKBKE, CARD11,
TNFRSF10B, RIPK1, RIPK2
PVR, IRAK2, IRAK1, BCL10, IL6,
CRTAM, CARD9, RELA, STAT5B,
GO:0031349~positive regulation of 1.77777777 KLRK1, TLR2, NFKBIA, TLR3, TLR4, 1352 9.54412369 2.00E-1 24 1.35E-16 466 73 3.39E-13 3.55E-15 defense response 8 TLR7, TLR8, IRAK3, TNFRSF1A, 8 9 3
MYD88, IRF7, TICAM1, RIPK2, LBP,
CD226
GO:0019882~antigen processing and 1.85185185 HLA-DQB1, HLA-DRB1, CD8A, 1352 8.74398883 4.00E-1 25 2.66E-16 466 83 6.77E-13 7.11E-15 presentation 2 HLA-DRB3, IFI30, HLA-DMB, 8 1 3 HLA-DMA, TAPBP, RAET1E, TAP2,
IFNG, HLA-DRB4, HLA-DRB5, ERAP1,
ERAP2, HLA-DPB1, TRAF6, HLA-DOA,
HLA-DOB, RELB, HLA-DQA2,
HLA-DQA1, ULBP3, ULBP2, HLA-DPA1,
HLA-DRA
TNF, PANX1, NFKBIE, NFKBIB, TGFB3,
NFKBIA, CDH1, GLI3, IL10, TGFB1,
GO:0070201~regulation of establishment 2.14814814 TGFB2, SAA1, IFNG, PYCARD, IL1B, 1352 6.95761359 9.99E-1 29 6.04E-16 466 121 1.69E-12 1.77E-14 of protein localization 8 TRAF6, IL1A, BMP4, IL6, CRTAM, 8 2 3
SMAD4, SMAD3, CD40, FOXP3, SMO,
P2RX7, CD40LG, EDA, IL2
IRAK2, IRAK1, BCL10, RELA, TLR2, GO:0002218~activation of innate 1.03703703 1352 21.3905579 3.21E-1 14 1.76E-15 KLRK1, TLR3, NFKBIA, TLR4, TLR7, 466 19 5.42E-12 5.58E-14 immune response 7 8 4 2 IRAK3, MYD88, TICAM1, RIPK2
IRAK2, IRAK1, BCL10, RELA, TLR2, GO:0002758~innate immune 1.03703703 1352 21.3905579 3.21E-1 14 1.76E-15 KLRK1, TLR3, NFKBIA, TLR4, TLR7, 466 19 5.42E-12 5.58E-14 response-activating signal transduction 7 8 4 2 IRAK3, MYD88, TICAM1, RIPK2
IL6, IL5, IL7, STAT5B, TNFSF12, CD40,
GO:0050864~regulation of B cell 1.48148148 PAWR, IL10, TGFB1, BTLA, CARD11, 1352 11.3843305 3.41E-1 20 1.89E-15 466 51 5.76E-12 5.87E-14 activation 1 CDKN1A, CDKN2A, TICAM1, IFNG, 8 6 2
IL2RG, FAS, INPP5D, IL2, SYK
WNT5A, FGFR1, NOG, THRA, PTGS2,
GO:0001501~skeletal system 3.33333333 FGF9, TCOF1, JAG2, TGFB3, TP63, 1352 4.21E-1 45 2.33E-15 466 319 4.09514712 7.11E-12 7.18E-14 development 3 ZBTB16, ZEB1, SOX9, GLI2, GLI3, 8 2
CBFB, TGFB1, VDR, TNFRSF11A, CHD7, CTGF, TRAF6, RUNX2, MYC, GHR,
EGFR, BMP4, BMP2, LGALS3, SMAD5,
SMAD3, TBX1, SMAD1, PTHLH, SMO,
P2RX7, MSX1, TNFSF11, DLX5, SIX1,
ROR2, TFAP2A, PBX1, FOXC1, COL1A1
TNF, PANX1, NFKBIE, NFKBIB, TGFB3,
NFKBIA, CDH1, GLI3, IL10, TGFB1,
GO:0032880~regulation of protein 2.22222222 TGFB2, SAA1, IFNG, PYCARD, IL1B, 1352 6.31087889 4.61E-1 30 2.57E-15 466 138 7.79E-12 7.78E-14 localization 2 TRAF6, IL1A, APC, BMP4, IL6, CRTAM, 8 5 2
SMAD4, SMAD3, CD40, FOXP3, SMO,
P2RX7, CD40LG, EDA, IL2
CSF2, CAV1, TNF, PML, TGFB3,
NFKBIA, KITLG, TLR4, TGFB1, EDNRB,
PTK2B, APOE, ATG7, IFNG, IL1B,
GO:0051247~positive regulation of 2.88888888 FBXO4, AXIN1, CD28, GHR, SYK, APC, 1352 4.65914269 6.01E-1 39 3.35E-15 466 243 1.02E-11 1.01E-13 protein metabolic process 9 BMP4, BCL10, IL3, BMP2, IL6, IL5, 8 1 2
SMAD4, FOXP3, UBE2N, GH1, P2RX7,
CBLB, EP300, NEDD4, TRIM32, CD81,
PIAS1, IL2
BMP4, CRTAM, IL6, TNF, PANX1,
TGFB3, SMAD4, SMAD3, CDH1, GLI3, GO:0051222~positive regulation of 1352 9.53225289 6.21E-1 22 1.62962963 3.48E-15 IL10, TGFB1, TGFB2, SMO, P2RX7, 466 67 1.05E-11 1.03E-13 protein transport 8 9 2 SAA1, IFNG, PYCARD, IL1B, EDA, IL1A,
IL2
GO:0002703~regulation of leukocyte 1.55555555 PVR, TRAF2, CRTAM, STAT5B, KLRK1, 1352 9.99394920 1.08E-1 21 6.04E-15 466 61 1.83E-11 1.78E-13 mediated immunity 6 MALT1, TNFSF12, CD40, FOXP3, IL7R, 8 1 1 IL10, TGFB1, MAP3K7, P2RX7, TAP2,
IFNG, IL1B, TRAF6, CD226, IL2, SYK
CD8A, STAT5B, JAG2, SOX4, PRKDC,
IL7R, HLA-DMA, IL10, TGFB1, CBFB, 1.92592592 1352 7.32797199 1.14E-1 GO:0030098~lymphocyte differentiation 26 6.36E-15 VCAM1, CHD7, FAS, BLNK, SYK, APC, 466 103 1.93E-11 1.86E-13 6 8 9 1 CD28, EGR1, IL7, RELB, TP53, MALT1,
CARD11, CD40LG, IRF1, IL2
PVR, TRAF2, CRTAM, STAT5B, KLRK1,
GO:0002706~regulation of lymphocyte 1.48148148 MALT1, TNFSF12, CD40, FOXP3, IL7R, 1352 10.7518677 1.16E-1 20 6.43E-15 466 54 1.96E-11 1.87E-13 mediated immunity 1 TGFB1, IL10, MAP3K7, P2RX7, TAP2, 8 5 1
IFNG, IL1B, TRAF6, CD226, IL2
FGFR2, FGFR1, NOG, FGF8, CD8A,
FGF9, ERBB2, STAT5B, PML, TGFB3,
FGF10, KIT, PTEN, TGFB1, TGFB2,
MAP3K7, IGF1R, FOS, CTGF, PTK2B,
GO:0007167~enzyme linked receptor 3.40740740 RAPGEF1, SYK, GHR, BMP4, TXNIP, 1352 3.90462565 1.18E-1 46 6.53E-15 466 342 2.00E-11 1.89E-13 protein signaling pathway 7 EGFR, IRAK1, IRS2, BMP2, CBL, 8 6 1
SMAD5, SMAD4, SMAD3, SMAD2,
SMAD1, TAB1, IRS1, STAT3, GH1,
MSX1, PRLR, VEGFA, ROR2, FOXC1,
PTPN1, JAK3
IL6, IL5, IL2RA, IL7, EFNB1, IL18,
GO:0050671~positive regulation of 1.48148148 STAT5B, CD40, PDCD1LG2, VCAM1, 1352 10.5563792 1.72E-1 20 9.56E-15 466 55 2.91E-11 2.72E-13 lymphocyte proliferation 1 CARD11, CDKN1A, TICAM1, IFNG, 8 4 1
RIPK2, IL1B, ICOSLG, IL2, CD28, SYK
GO:0002221~pattern recognition receptor 13 0.96296296 1.26E-14 IRAK2, IRAK1, BCL10, RELA, TLR2, 466 17 1352 22.1994445 3.83E-11 3.54E-13 2.26E-1 signaling pathway 3 TLR3, NFKBIA, TLR4, TLR7, IRAK3, 8 8 1
MYD88, TICAM1, RIPK2
CSF2, CAV1, TNF, TGFB3, KITLG, TLR4,
TGFB1, EDNRB, IFNG, IL1B, GHR, SYK, GO:0042327~positive regulation of 1.85185185 1352 7.48196982 2.52E-1 25 1.39E-14 AXIN1, BMP4, EGFR, IL3, BCL10, IL6, 466 97 4.27E-11 3.91E-13 phosphorylation 2 8 4 1 BMP2, IL5, SMAD4, GH1, P2RX7, CD81,
IL2
IL6, IL5, IL2RA, IL7, EFNB1, IL18,
GO:0070665~positive regulation of 1.48148148 STAT5B, CD40, PDCD1LG2, VCAM1, 1352 10.3678724 2.54E-1 20 1.41E-14 466 56 4.30E-11 3.91E-13 leukocyte proliferation 1 CARD11, CDKN1A, TICAM1, IFNG, 8 7 1
RIPK2, IL1B, ICOSLG, IL2, CD28, SYK
IL6, IL5, IL2RA, IL7, EFNB1, IL18,
GO:0032946~positive regulation of 1.48148148 STAT5B, CD40, PDCD1LG2, VCAM1, 1352 10.3678724 2.54E-1 20 1.41E-14 466 56 4.30E-11 3.91E-13 mononuclear cell proliferation 1 CARD11, CDKN1A, TICAM1, IFNG, 8 7 1
RIPK2, IL1B, ICOSLG, IL2, CD28, SYK
CSF2, CAV1, TNF, PML, TGFB3, KITLG,
TLR4, TGFB1, EDNRB, CDKN2A, ATG5,
PTK2B, ATG7, IFNG, IL1B, RAPGEF4,
GO:0031399~regulation of protein 3.11111111 FBXO4, RAPGEF3, AXIN1, GHR, SYK, 1352 4.13309085 3.08E-1 42 1.71E-14 466 295 5.21E-11 4.70E-13 modification process 1 BMP4, EGFR, BCL10, IL3, BMP2, IL6, 8 6 1
MLL, IL5, SOCS3, SOCS1, FBXO2,
SMAD4, FOXP3, TP73, UBE2N, GH1,
P2RX7, RIPK1, CD81, PIAS1, IL2
CSF2, TNF, STAT5B, NFKBIA, TP63, 2.59259259 1352 4.93228884 3.58E-1 GO:0006916~anti-apoptosis 35 1.98E-14 NFKB1, IL10, IGF1R, MYD88, APOE, 466 206 6.06E-11 5.41E-13 3 8 5 1 IL1B, FAS, TRAF6, MYC, TWIST2, IL1A, IL3, IRAK1, SOCS3, IL7, RELA, MALT1,
ESR2, TAX1BP1, PRLR, TNFRSF10D,
CD40LG, VEGFA, RIPK2, FOXC1, NGFR,
TNFAIP3, IKBKB, IFI6, IL2
IRAK2, BCL10, IRAK1, IRAK3, MYD88, GO:0002224~toll-like receptor signaling 0.88888888 1352 24.8828939 4.23E-1 12 2.34E-14 TICAM1, TLR2, NFKBIA, TLR3, RIPK2, 466 14 7.14E-11 6.32E-13 pathway 9 8 3 1 TLR4, TLR7
E2F1, THRA, FOXA2, STAT5B, PAX6,
TGFB3, TP63, NFKB1, PAWR, ZEB1,
PAX3, GLI2, CBFB, TGFB1, FOS, PAX9,
MYC, TWIST2, EGR1, CIITA, EGR2,
RARG, RXRA, RELA, SOX11, TP53, RB1,
ESR2, IFNAR2, MSX1, EP300, VEGFA,
GO:0006357~regulation of transcription 5.11111111 SIX1, TFAP2A, FOXC1, TNF, LITAF, 1352 2.75525854 5.09E-1 69 2.82E-14 466 727 8.60E-11 7.55E-13 from RNA polymerase II promoter 1 PRKDC, NFKBIA, SOX9, TNFRSF1A, 8 4 1
VDR, HAND2, RUNX2, BMP4, BMP2,
IL6, MLL, SMAD5, CREBBP, SMAD4,
SMAD3, SMAD2, TBX1, SMAD1, FOXP3,
STAT3, STAT2, CDKN1C, NOTCH1,
NEDD4, IRF7, IRF8, IRF1, IRF2, PBX1,
JAK3, IRF4, IL2
CSF2, CAV1, TNF, TGFB3, KITLG, TLR4,
TGFB1, EDNRB, IFNG, IL1B, GHR, SYK, GO:0045937~positive regulation of 1.85185185 1352 5.27E-1 25 2.92E-14 AXIN1, BMP4, EGFR, IL3, BCL10, IL6, 466 100 7.25751073 8.91E-11 7.74E-13 phosphate metabolic process 2 8 1 BMP2, IL5, SMAD4, GH1, P2RX7, CD81,
IL2 CSF2, CAV1, TNF, TGFB3, KITLG, TLR4,
TGFB1, EDNRB, IFNG, IL1B, GHR, SYK, GO:0010562~positive regulation of 1.85185185 1352 5.27E-1 25 2.92E-14 AXIN1, BMP4, EGFR, IL3, BCL10, IL6, 466 100 7.25751073 8.91E-11 7.74E-13 phosphorus metabolic process 2 8 1 BMP2, IL5, SMAD4, GH1, P2RX7, CD81,
IL2
TNF, PANX1, NFKBIE, NFKBIB, PTGS1,
TGFB3, NFKBIA, CDH1, GLI3, TGFB1,
IL10, TGFB2, CHD7, CDKN2A, SAA1,
GO:0060341~regulation of cellular 2.81481481 IFNG, PYCARD, IL1B, RAPGEF4, 1352 4.44815173 6.55E-1 38 3.63E-14 466 248 1.11E-10 9.55E-13 localization 5 TRAF6, CAMK2A, IL1A, SYK, APC, 8 8 1
BMP4, IL6, CRTAM, SMAD4, SMAD3,
CD40, PARK2, FOXP3, SMO, P2RX7,
NEDD4, CD40LG, EDA, IL2
E2F1, TP63, NFKB1, PAWR, PAX3,
TNFSF12, PTEN, PDCD1, CDKN2A,
NOD1, ATG5, IFNG, TICAM1, IL1B, FAS,
MYC, IL1A, BCL10, TP53, NLRP1,
EP300, TNFRSF10B, TNFRSF10D, RIPK1,
RIPK2, NGFR, EIF2AK2, TNFAIP3, 4.59259259 1352 2.94576540 7.15E-1 GO:0012501~programmed cell death 62 3.96E-14 TRAF1, TRAF2, TNF, UBE2Z, LITAF, 466 611 1.21E-10 1.03E-12 3 8 3 1 TNFRSF12A, PML, PRKDC, NFKBIA,
KIT, SFN, ZBTB16, TNFRSF1A,
TNFRSF1B, HAND2, PTK2B, PYCARD,
XAF1, INPP5D, TRAF6, AXIN1, TRAF3,
PTPN6, RNF144B, IL6, IL2RA, MLL,
SMAD3, STAT1, TP73, TAX1BP1, CDKN1B, CD14, IFI6
E2F1, FGF8, TP63, FGF10, ZEB1, GLI2,
PTEN, TGFB1, IL10, ISG20, TGFB2, ILK,
RAPGEF3, PRL, MYC, IL1A, OCA2, SYK,
EGFR, CRTAM, IRS2, RXRA, SOX11,
3.77777777 CD160, TP53, CD40, IFNAR2, CD40LG, 1352 3.39571602 8.79E-1 GO:0008283~cell proliferation 51 4.87E-14 466 436 1.49E-10 1.26E-12 8 CD81, VEGFA, TXN, RIPK2, FOXC1, 8 9 1
ERBB2, SIPA1, KITLG, KIT, SFN, IL7R,
PTK2B, BMP4, IL2RA, CREBBP, MALT1,
TBX1, P2RX7, S100B, IRF6, CD274, IRF2,
IL5RA
SOCS3, STAT5B, SOCS1, STAT1, AGER,
1.25925925 STAT3, IFNAR1, STAT2, IFNAR2, GH1, 1352 12.6541212 9.67E-1 GO:0007259~JAK-STAT cascade 17 5.36E-14 466 39 1.64E-10 1.37E-12 9 PRLR, PTK2B, IFNG, CCR2, PIAS1, PRL, 8 7 1
GHR
IRAK1, PTGS2, SOCS3, RELA, STAT5B,
SOCS1, NFKBIA, TLR4, STAT1, IL10, GO:0032496~response to 1352 8.29429797 1.42E-1 22 1.62962963 7.85E-14 IRAK3, FOS, TNFRSF1A, P2RX7, 466 77 2.39E-10 2.00E-12 lipopolysaccharide 8 7 0 MYD88, TICAM1, RIPK2, IL1B, IRF3,
LBP, CD14, PTAFR
CAV1, NOG, ERBB2, STAT5B, PAX6,
TGFB3, FGF10, TP63, CDH1, GLI2, GLI3, 2.07407407 1352 6.02104593 1.55E-1 GO:0048732~gland development 28 8.57E-14 TGFB1, TGFB2, IGF1R, PRL, BMP4, 466 135 2.61E-10 2.16E-12 4 8 9 0 EGFR, IRS2, TBX1, IRS1, PTHLH, CRKL,
PRLR, IRF6, SIX1, FOXC1, PBX1, EDA
GO:0032755~positive regulation of 13 0.96296296 9.58E-14 IL6, TNF, CARD9, TLR2, TLR3, TLR4, 466 19 1352 19.8626609 2.92E-10 2.40E-12 1.73E-1 interleukin-6 production 3 TLR7, P2RX7, NOD1, TICAM1, RIPK2, 8 4 0
IL1B, LBP
IRAK2, IRAK1, IL6, IL1R1, TNF, IL5,
RELA, SOCS1, STAT5B, KIT, STAT1, GO:0019221~cytokine-mediated 1.55555555 1352 8.70901287 2.11E-1 21 1.17E-13 STAT3, IRAK4, TNFRSF1A, IRAK3, 466 70 3.56E-10 2.90E-12 signaling pathway 6 8 6 0 RIPK1, CCR2, PYCARD, IL1B, JAK3,
IL1A
E2F1, TP63, NFKB1, PAWR, TNFSF12,
PAX3, PTEN, PDCD1, TGFB1, TGFB2,
NOD1, CDKN2A, ATG5, IFNG, TICAM1,
IL1B, FAS, MYC, IL1A, BCL10, TP53,
GAN, NLRP1, EP300, TNFRSF10B,
TNFRSF10D, RIPK1, RIPK2, NGFR,
EIF2AK2, TNFAIP3, TRAF1, TRAF2, 4.96296296 1352 2.70516394 3.12E-1 GO:0008219~cell death 67 1.73E-13 TNF, UBE2Z, LITAF, TNFRSF12A, PML, 466 719 5.27E-10 4.25E-12 3 8 4 0 PRKDC, NFKBIA, KIT, SFN, ZBTB16,
TNFRSF1A, TNFRSF1B, HAND2, PTK2B,
PYCARD, XAF1, INPP5D, TRAF6,
AXIN1, TRAF3, PTPN6, RNF144B, IL6,
IL2RA, MLL, SMAD3, STAT1, TAX1BP1,
TP73, P2RX7, CDKN1B, UBA1, CD14,
IFI6
BMP4, CSF2, IL3, CAV1, IL6, BMP2,
GO:0001934~positive regulation of 1.70370370 TNF, IL5, TGFB3, SMAD4, KITLG, TLR4, 1352 7.50214592 3.30E-1 23 1.83E-13 466 89 5.58E-10 4.46E-12 protein amino acid phosphorylation 4 TGFB1, GH1, EDNRB, P2RX7, CD81, 8 3 0
IFNG, IL1B, AXIN1, IL2, SYK, GHR CSF2, CAV1, TNF, TGFB3, KITLG, TLR4,
TGFB1, EDNRB, PTK2B, IFNG, IL1B,
GO:0001932~regulation of protein amino 2.29629629 RAPGEF4, RAPGEF3, AXIN1, GHR, 1352 5.20191520 3.36E-1 31 1.86E-13 466 173 5.69E-10 4.51E-12 acid phosphorylation 6 SYK, BMP4, EGFR, IL3, BMP2, IL6, IL5, 8 5 0
SOCS3, SOCS1, SMAD4, TP73, GH1,
P2RX7, RIPK1, CD81, IL2
E2F1, TP63, NFKB1, PAWR, TNFSF12,
PAX3, PTEN, PDCD1, TGFB1, TGFB2,
NOD1, CDKN2A, ATG5, IFNG, TICAM1,
IL1B, FAS, MYC, IL1A, BCL10, TP53,
GAN, NLRP1, EP300, TNFRSF10B,
TNFRSF10D, RIPK1, RIPK2, NGFR,
EIF2AK2, TNFAIP3, TRAF1, TRAF2, 4.96296296 1352 2.68648187 4.26E-1 GO:0016265~death 67 2.36E-13 TNF, UBE2Z, LITAF, TNFRSF12A, PML, 466 724 7.21E-10 5.68E-12 3 8 2 0 PRKDC, NFKBIA, KIT, SFN, ZBTB16,
TNFRSF1A, TNFRSF1B, HAND2, PTK2B,
PYCARD, XAF1, INPP5D, TRAF6,
AXIN1, TRAF3, PTPN6, RNF144B, IL6,
IL2RA, MLL, SMAD3, STAT1, TAX1BP1,
TP73, P2RX7, CDKN1B, UBA1, CD14,
IFI6
EGR1, CD8A, IL7, RELB, STAT5B, TP53,
1.48148148 JAG2, PRKDC, SOX4, IL7R, HLA-DMA, 1352 8.93232089 5.52E-1 GO:0030217~T cell differentiation 20 3.06E-13 466 65 9.34E-10 7.30E-12 1 TGFB1, CARD11, CHD7, IRF1, FAS, 8 8 0
CD28, IL2, APC, SYK
GO:0032270~positive regulation of 35 2.59259259 7.88E-13 CSF2, CAV1, TNF, PML, TGFB3, 466 233 1352 4.36073606 2.40E-09 1.86E-11 1.42E-0 cellular protein metabolic process 3 NFKBIA, KITLG, TLR4, TGFB1, EDNRB, 8 1 9
PTK2B, APOE, ATG7, IFNG, IL1B,
FBXO4, AXIN1, CD28, GHR, SYK,
BMP4, BCL10, IL3, BMP2, IL6, IL5,
SMAD4, FOXP3, UBE2N, GH1, P2RX7,
EP300, CD81, PIAS1, IL2
E2F1, TP63, NFKB1, PAWR, PAX3,
TNFSF12, PTEN, PDCD1, CDKN2A,
NOD1, ATG5, TICAM1, IFNG, IL1B, FAS,
MYC, IL1A, BCL10, TP53, NLRP1,
TNFRSF10B, EP300, TNFRSF10D, RIPK1,
RIPK2, NGFR, EIF2AK2, TNFAIP3, 1352 2.84513709 1.46E-0 GO:0006915~apoptosis 59 4.37037037 8.08E-13 TRAF1, TRAF2, TNF, UBE2Z, LITAF, 466 602 2.47E-09 1.90E-11 8 7 9 TNFRSF12A, PML, NFKBIA, SFN,
ZBTB16, TNFRSF1A, TNFRSF1B,
HAND2, PTK2B, PYCARD, XAF1,
INPP5D, TRAF6, AXIN1, TRAF3, PTPN6,
RNF144B, IL6, IL2RA, MLL, SMAD3,
STAT1, TP73, TAX1BP1, CD14, IFI6
HLA-DQB1, HLA-DRB1, HLA-DRB3,
IFI30, HLA-DMB, HLA-DMA, GO:0002504~antigen processing and 1.11111111 HLA-DQA2, HLA-DQA1, HLA-DRB4, 1352 13.1954740 2.15E-0 presentation of peptide or polysaccharide 15 1.19E-12 466 33 3.64E-09 2.78E-11 1 HLA-DRB5, HLA-DPA1, HLA-DPB1, 8 5 9 antigen via MHC class II TRAF6, HLA-DOA, HLA-DOB,
HLA-DRA
GO:0050871~positive regulation of B cell 15 1.11111111 1.19E-12 IL6, IL5, IL7, STAT5B, TNFSF12, CD40, 466 33 1352 13.1954740 3.64E-09 2.78E-11 2.15E-0 activation 1 TGFB1, CARD11, CDKN1A, TICAM1, 8 5 9
IFNG, IL2RG, INPP5D, SYK, IL2
GO:0002822~regulation of adaptive PVR, TRAF2, MALT1, CD40, TNFSF12, immune response based on somatic 1.33333333 FOXP3, IL7R, TGFB1, IL10, MAP3K7, 1352 9.50074131 3.61E-0 recombination of immune receptors built 18 2.00E-12 466 55 6.10E-09 4.62E-11 3 P2RX7, TAP2, IFNG, IL1B, RARA, 8 9 9 from immunoglobulin superfamily TRAF6, CD226, IL2 domains
BCL10, TRAF2, IL6, TNF, MALT1, CD40,
GO:0002700~regulation of production of 1.18518518 TNFSF12, FOXP3, TGFB1, IL10, 1352 11.3287972 4.45E-0 16 2.47E-12 466 41 7.52E-09 5.66E-11 molecular mediator of immune response 5 MAP3K7, IRAK3, CD40LG, IFNG, 8 4 9
TRAF6, IL2
PVR, TRAF2, MALT1, CD40, TNFSF12,
GO:0002819~regulation of adaptive 1.33333333 FOXP3, IL7R, TGFB1, IL10, MAP3K7, 1352 9.33108522 5.02E-0 18 2.78E-12 466 56 8.48E-09 6.33E-11 immune response 3 P2RX7, TAP2, IFNG, IL1B, RARA, 8 4 9
TRAF6, CD226, IL2
CAV1, TNF, PTGS2, ERBB2, PTGS1,
STAT5B, TGFB3, PTEN, TGFB1, IL10,
GO:0048545~response to steroid 2.29629629 TGFB2, FOS, GATA3, IL1B, RARA, FAS, 1352 4.68714234 5.53E-0 31 3.07E-12 466 192 9.36E-09 6.93E-11 hormone stimulus 6 GHR, TXNIP, BMP4, IL6, SOCS3, RELA, 8 6 9
RXRA, IL1RN, SOCS1, ESR2, STAT3,
GH1, CDKN1A, EP300, COL1A1
NOG, THRA, PTGS2, FGF9, TGFB3,
GLI2, SOX9, TGFB1, CBFB, TNFRSF11A, 1.85185185 1352 5.90041522 6.66E-0 GO:0060348~bone development 25 3.69E-12 CTGF, TRAF6, RUNX2, GHR, EGFR, 466 123 1.13E-08 8.28E-11 2 8 7 9 BMP4, BMP2, SMAD5, SMAD3, SMAD1,
PTHLH, SMO, TNFSF11, FOXC1, COL1A1
CRTAM, IL6, TNF, PANX1, TGFB3,
GO:0050708~regulation of protein 1.33333333 CD40, FOXP3, TGFB1, IL10, TGFB2, 1352 9.00932366 9.49E-0 18 5.26E-12 466 58 1.60E-08 1.17E-10 secretion 3 P2RX7, CD40LG, SAA1, IFNG, PYCARD, 8 4 9
TRAF6, IL1A, IL2
IRAK2, IRAK1, BCL10, RELA, CD247,
KLRK1, TLR2, NFKBIA, TLR3, MALT1, GO:0002253~activation of immune 1352 6.79426536 9.81E-0 22 1.62962963 5.44E-12 TLR4, TLR7, UBE2N, MAP3K7, IRAK3, 466 94 1.66E-08 1.20E-10 response 8 4 9 CD19, MYD88, TICAM1, IKBKG, RIPK2,
TRAF6, SYK
WNT5A, NOG, FGF8, FOXA2, FGF9,
JAG2, TGFB3, TP63, FGF10, ZBTB16,
PAX3, ZEB1, GLI2, GLI3, MAP3K7,
2.88888888 CUL3, CHD7, TRAF6, MYC, BMP4, 1352 3.68785561 1.13E-0 GO:0048598~embryonic morphogenesis 39 6.24E-12 466 307 1.90E-08 1.37E-10 9 BCL10, RARG, SMAD4, TP53, SMAD3, 8 5 8
TBX1, SMAD2, SMAD1, VASP,
NOTCH1, MSX1, DLX5, FOXG1, SIX1,
LRP6, ROR2, TFAP2A, PBX1, FOXC1
MAVS, IL1R1, IFIH1, TBK1, TLR1, TLR2,
NLRX1, CALCOCO2, TLR3, TLR4, TLR5, 1.92592592 1352 5.46942837 1.33E-0 GO:0045087~innate immune response 26 7.36E-12 TLR7, TLR8, TGFB1, TLR9, TNFRSF1A, 466 138 2.24E-08 1.60E-10 6 8 6 8 MYD88, IL1RAP, LBP, TBKBP1, CIITA,
BCL10, TLR10, MALT1, DDX58, CYBB
CSF2, CAV1, TNF, PML, TGFB3, KITLG, GO:0031401~positive regulation of 2.22222222 1352 4.65722613 1.56E-0 30 8.63E-12 TLR4, TGFB1, EDNRB, ATG7, IFNG, 466 187 2.63E-08 1.87E-10 protein modification process 2 8 7 8 IL1B, FBXO4, AXIN1, GHR, SYK, BMP4, IL3, BCL10, BMP2, IL6, IL5, SMAD4,
FOXP3, UBE2N, GH1, P2RX7, CD81,
PIAS1, IL2
CARD9, TLR1, TLR2, TLR3, TLR4, IL10, GO:0032680~regulation of tumor 1.03703703 1352 13.1103419 1.68E-0 14 9.29E-12 IRAK3, MYD88, NOD1, TICAM1, RIPK2, 466 31 2.83E-08 1.99E-10 necrosis factor production 7 8 6 8 RARA, LBP, CD14
TRAF2, CAV1, TNF, ERBB2, TGFB3,
TLR3, KITLG, SFN, KIT, PTEN, TGFB1,
TGFB2, MAP3K7, IRAK3, CDKN2A,
PTK2B, APOE, ILK, IL1B, TRAF6, APC, 3.11111111 1352 3.41529916 1.83E-0 GO:0043549~regulation of kinase activity 42 1.02E-11 GHR, SYK, EGFR, IRAK1, MALT1, RB1, 466 357 3.10E-08 2.17E-10 1 8 7 8 TAB1, IRS1, CISH, TP73, CDKN1C, GH1,
CDKN1A, P2RX7, CDKN1B,
TNFRSF10B, PRLR, RIPK1, IKBKG,
CD81, IL2
TRAF2, CAV1, TNF, ERBB2, TGFB3,
TLR3, KITLG, SFN, KIT, PTEN, TGFB1,
TGFB2, MAP3K7, IRAK3, CDKN2A,
PTK2B, APOE, ILK, IL1B, TRAF6, APC, GO:0045859~regulation of protein kinase 3.03703703 1352 3.44994712 2.47E-0 41 1.37E-11 GHR, SYK, EGFR, IRAK1, MALT1, RB1, 466 345 4.17E-08 2.90E-10 activity 7 8 9 8 TAB1, CISH, TP73, CDKN1C, GH1,
CDKN1A, P2RX7, CDKN1B,
TNFRSF10B, PRLR, RIPK1, IKBKG,
CD81, IL2
GO:0070664~negative regulation of 1.03703703 IL2RA, ERBB2, CTLA4, PAWR, FOXP3, 1352 12.7006437 2.73E-0 14 1.52E-11 466 32 4.62E-08 3.19E-10 leukocyte proliferation 7 TGFB1, IL10, PDCD1LG2, BTLA, CBLB, 8 8 8 CDKN2A, CD274, INPP5D, IL2
IL2RA, ERBB2, CTLA4, PAWR, FOXP3, GO:0050672~negative regulation of 1.03703703 1352 12.7006437 2.73E-0 14 1.52E-11 TGFB1, IL10, PDCD1LG2, BTLA, CBLB, 466 32 4.62E-08 3.19E-10 lymphocyte proliferation 7 8 8 8 CDKN2A, CD274, INPP5D, IL2
IL2RA, ERBB2, CTLA4, PAWR, FOXP3, GO:0032945~negative regulation of 1.03703703 1352 12.7006437 2.73E-0 14 1.52E-11 TGFB1, IL10, PDCD1LG2, BTLA, CBLB, 466 32 4.62E-08 3.19E-10 mononuclear cell proliferation 7 8 8 8 CDKN2A, CD274, INPP5D, IL2
IL6, IL2RA, IL18, EFNB1, STAT5B, GO:0042102~positive regulation of T cell 1.11111111 1352 11.1654011 3.28E-0 15 1.82E-11 PDCD1LG2, VCAM1, CARD11, IFNG, 466 39 5.54E-08 3.80E-10 proliferation 1 8 2 8 RIPK2, IL1B, ICOSLG, SYK, CD28, IL2
IL2RA, IL7, ERBB2, STAT5B, CTLA4,
GO:0045619~regulation of lymphocyte 1.33333333 ZEB1, IL7R, HLA-DMA, CARD11, 1352 8.29429797 4.15E-0 18 2.30E-11 466 63 7.02E-08 4.78E-10 differentiation 3 CDKN2A, RARA, IL2RG, FAS, IRF4, 8 7 8
INPP5D, HLA-DOA, IL2, SYK
CAV1, TNF, PANX1, TGFB3, NFKBIA,
FGF10, CDH1, GLI3, TGFB1, IL10,
GO:0051050~positive regulation of TGFB2, APOE, SAA1, IFNG, PYCARD, 1352 4.16574606 5.42E-0 32 2.37037037 3.01E-11 466 223 9.17E-08 6.20E-10 transport IL1B, NEDD4L, IL1A, SYK, BMP4, IL6, 8 9 8
IRS2, CRTAM, CBL, SMAD4, SMAD3,
IRS1, SMO, P2RX7, NEDD4, EDA, IL2
NOG, STAT5B, TGFB3, TLR2, JAG2,
FGF10, TGFB1, TGFB2, MAP3K7,
GO:0007166~cell surface receptor linked 8.66666666 LILRA1, MYD88, GAB2, CTGF, APOE, 1352 1.83001886 6.13E-0 117 3.40E-11 466 1856 1.04E-07 6.95E-10 signal transduction 7 ILK, IFNG, RAPGEF4, KLRD1, 8 9 8
RAPGEF1, SYK, EGFR, BCL10, IRS2,
RARG, CD40, IRS1, NCAM1, PTHLH, LILRB2, MSX1, CCR6, LILRB5, VEGFA,
CCR2, RIPK2, ROR2, KLRC1, FGFR2,
WNT5A, FGFR1, IL1R1, ERBB2, KLRK1,
NFKBIA, ITGB5, SOX4, ITGB7, TRAF6,
AXIN1, BMP4, PTPN6, BMP2, SMAD5,
SMAD4, SMAD3, SMAD2, MALT1,
SMAD1, AGER, BTLA, GH1, P2RX7,
CBLB, NOTCH1, IKBKG, CD274, PTPN1,
FGF8, CD8A, FGF9, TP63, GLI2, PTEN,
GLI3, EDNRB, FOS, TICAM1, LBP, PRL,
IFNGR2, GHR, IRAK2, IRAK1, CD160,
UBE2B, IFNAR1, UBE2N, SMO, IFNAR2,
KLRG1, TNFRSF10B, FOXC1, PTAFR,
CD247, PML, KIT, IL7R, IGF1R,
TNFRSF1B, PTK2B, APC, CD28, TXNIP,
IL2RA, CBL, TAB1, STAT1, CISH,
STAT3, IRF9, CD19, PRLR, LRP6, IRF3,
JAK3, CD14, IL2
TRAF2, CAV1, TNF, ERBB2, TGFB3,
TLR3, KITLG, SFN, KIT, PTEN, TGFB1,
TGFB2, MAP3K7, IRAK3, CDKN2A,
GO:0051338~regulation of transferase 3.11111111 PTK2B, APOE, ILK, IL1B, TRAF6, APC, 1352 3.27758549 6.81E-0 42 3.77E-11 466 372 1.15E-07 7.67E-10 activity 1 GHR, SYK, EGFR, IRAK1, MALT1, RB1, 8 1 8
TAB1, IRS1, CISH, TP73, CDKN1C, GH1,
CDKN1A, P2RX7, CDKN1B,
TNFRSF10B, PRLR, RIPK1, IKBKG, CD81, IL2
NOG, FGF9, TNFRSF12A, SIPA1,
STAT5B, PML, TP63, SFN, TGFB1,
TGFB2, CHD7, CDKN2A, CD44, CTGF,
2.96296296 APOE, PTK2B, PRSS2, ILK, IFNG, 1352 3.40528362 6.83E-0 GO:0040008~regulation of growth 40 3.79E-11 466 341 1.16E-07 7.65E-10 3 CAMK2D, PRL, GHR, IP6K2, IL7, SOCS3, 8 7 8
SOCS1, SMAD4, TP53, SMAD3, RB1,
ESR2, CISH, TP73, STAT3, GH1,
CDKN1A, CDKN1B, EP300, FOXC1, IL2
EGFR, BMP4, BMP2, NOG, THRA,
PTGS2, FGF9, SMAD5, TGFB3, SMAD3, 1.70370370 1352 5.80600858 8.05E-0 GO:0001503~ossification 23 4.46E-11 SMAD1, GLI2, CBFB, TGFB1, PTHLH, 466 115 1.36E-07 8.95E-10 4 8 4 8 SMO, TNFRSF11A, TNFSF11, CTGF,
FOXC1, COL1A1, TRAF6, RUNX2
CSF2, CAV1, TNF, PML, TGFB3,
NFKBIA, KITLG, TLR4, NFKB1, TGFB1,
IL10, EDNRB, CDKN2A, ATG5, PTK2B,
APOE, ATG7, IFNG, IL1B, RAPGEF4, GO:0032268~regulation of cellular 3.55555555 1352 2.93975118 9.76E-0 48 5.41E-11 FBXO4, RAPGEF3, AXIN1, CD28, GHR, 466 474 1.65E-07 1.08E-09 protein metabolic process 6 8 2 8 SYK, BMP4, EGFR, BCL10, IL3, BMP2,
IL6, MLL, IL5, SOCS3, SOCS1, FBXO2,
SMAD4, FOXP3, TP73, UBE2N, GH1,
P2RX7, EP300, RIPK1, CD81, PIAS1, IL2
BMP4, TNF, NFKBIE, NFKBIB, TGFB3, GO:0046822~regulation of 1.25925925 1352 8.50880568 1.12E-0 17 6.22E-11 SMAD4, SMAD3, NFKBIA, CDH1, GLI3, 466 58 1.90E-07 1.23E-09 nucleocytoplasmic transport 9 8 3 7 TGFB1, IL10, SMO, CDKN2A, NEDD4, IL1B, EDA
IL2RA, IL7, ERBB2, STAT5B, CTLA4,
GO:0045580~regulation of T cell 1.18518518 ZEB1, IL7R, HLA-DMA, CARD11, 1352 9.10746444 1.63E-0 16 9.03E-11 466 51 2.76E-07 1.78E-09 differentiation 5 CDKN2A, RARA, IL2RG, IRF4, 8 5 7
HLA-DOA, SYK, IL2
CAV1, THRA, TNF, PTGS2, ERBB2,
STAT5B, PTGS1, TGFB3, PRKDC, PTEN,
TGFB1, IL10, TGFB2, IGF1R, FOS,
GO:0009725~response to hormone 3.03703703 PTK2B, GATA3, IL1B, RARA, FAS, GHR, 1352 1.68E-0 41 9.33E-11 466 367 3.24313831 2.85E-07 1.82E-09 stimulus 7 BMP4, TXNIP, IRS2, IL6, EGR2, SOCS3, 8 7
RELA, RXRA, IL1RN, SOCS1, ESR2,
STAT1, UBE2B, IRS1, STAT3, GH1,
CDKN1A, EP300, PTPN1, COL1A1
WNT5A, NOG, FOXA2, FGF9, TGFB3,
FGF10, TP63, PAX3, GLI2, GLI3,
MAP3K7, CD44, CTGF, HAND2, ILK, 2.29629629 1352 4.09059695 1.85E-0 GO:0035295~tube development 31 1.03E-10 TRAF6, BMP4, BCL10, BMP2, SMAD4, 466 220 3.13E-07 2.00E-09 6 8 7 7 SMAD2, TAB1, VASP, PTHLH, NOTCH1,
EP300, VEGFA, SIX1, TFAP2A, PBX1,
FOXC1
TRAF2, CARD9, STAT5B, MALT1, GO:0032663~regulation of interleukin-2 0.96296296 1352 12.5796852 2.10E-0 13 1.16E-10 FOXP3, MAP3K7, CARD11, RIPK2, IL1B, 466 30 3.55E-07 2.25E-09 production 3 8 6 7 IRF4, TRAF6, IL1A, CD28
BCL10, CARD9, TLR2, TLR4, MALT1, 0.88888888 1352 14.5150214 2.12E-0 GO:0009620~response to fungus 12 1.17E-10 TGFB1, S100A12, MYD88, DEFA1B, 466 24 3.58E-07 2.25E-09 9 8 6 7 DEFA5, DEFA4, DEFA3, DEFA1 PVR, BCL10, TRAF2, CRTAM, STAT5B, GO:0002699~positive regulation of 1.11111111 1352 2.13E-0 15 1.18E-10 KLRK1, MALT1, MAP3K7, P2RX7, 466 44 9.89660554 3.61E-07 2.25E-09 immune effector process 1 8 7 TAP2, IL1B, LBP, TRAF6, CD226, SYK
EGFR, NOG, FGF9, ERBB2, PAX6,
GO:0050678~regulation of epithelial cell 1.33333333 SMAD3, FGF10, ESR2, TGFB1, TGFB2, 1352 7.35972919 3.29E-0 18 1.83E-10 466 71 5.57E-07 3.46E-09 proliferation 3 CDKN1C, EDNRB, NOTCH1, CDKN1B, 8 1 7
DLX5, VEGFA, PRL, APC
GO:0032760~positive regulation of tumor 0.74074074 NOD1, CARD9, MYD88, TICAM1, TLR2, 1352 19.3533619 4.66E-0 10 2.58E-10 466 15 7.88E-07 4.87E-09 necrosis factor production 1 TLR3, RIPK2, TLR4, LBP, CD14 8 5 7
CAV1, NOG, FOXA2, STAT5B, PAX6,
NFKBIA, TLR3, FGF10, TP63, TLR4, KIT,
GO:0045596~negative regulation of cell 2.22222222 ZEB1, ZBTB16, GLI2, SOX9, GLI3, 1352 4.03195040 5.58E-0 30 3.09E-10 466 216 9.44E-07 5.79E-09 differentiation 2 TGFB1, INPP5D, TWIST2, APC, BMP4, 8 5 7
CREBBP, TP53, CTLA4, SMAD3, PTHLH,
NOTCH1, FOXG1, PBX1, NGFR
PVR, TNF, TNFRSF12A, PAX6, PRKDC,
KITLG, PAX3, KIT, TNFSF12, PRKG1,
PTEN, TGFB1, IL10, TGFB2, VCAM1, 2.51851851 1352 3.57616470 7.28E-0 GO:0016477~cell migration 34 4.04E-10 EDNRB, GAB2, CD44, CTGF, PTK2B, 466 276 1.23E-06 7.51E-09 9 8 7 7 SAA1, IFNG, IL1B, SYK, APC, IL6,
EFNB1, TBX1, ESR2, SMO, CD34, SIX1,
LRP6, FOXC1
IL6, TNF, CARD9, FGF9, ERBB2, TLR3, GO:0043410~positive regulation of 1.11111111 1352 9.07188841 7.89E-0 15 4.37E-10 TLR4, TGFB2, MAP3K7, P2RX7, NOD1, 466 48 1.33E-06 8.09E-09 MAPKKK cascade 1 8 2 7 ILK, RIPK2, IL1B, AXIN1
GO:0009719~response to endogenous 42 3.11111111 5.24E-10 CAV1, THRA, TNF, PTGS2, ERBB2, 466 405 1352 3.01052296 1.60E-06 9.63E-09 9.45E-0 stimulus 1 STAT5B, PTGS1, TGFB3, PRKDC, PTEN, 8 9 7
TGFB1, IL10, TGFB2, IGF1R, FOS,
PTK2B, GATA3, IL1B, RARA, FAS, GHR,
BMP4, TXNIP, IRS2, IL6, EGR2, SOCS3,
RELA, RXRA, IL1RN, SOCS1, ESR2,
SMAD1, STAT1, UBE2B, IRS1, STAT3,
GH1, CDKN1A, EP300, PTPN1, COL1A1
JAG2, TP63, PAX3, GLI2, GLI3, TGFB2,
MAP3K7, CD44, ILK, TRAF6, CHUK,
BMP4, BCL10, BMP2, RXRA, SMAD4, 1352 4.35450643 9.45E-0 GO:0048729~tissue morphogenesis 27 2 5.24E-10 466 180 1.60E-06 9.57E-09 SMAD3, SMAD2, SMAD1, VASP, 8 8 7
NOTCH1, SIX1, TFAP2A, FOXC1, PBX1,
COL1A1, NGFR
BTLA, CBLB, CDKN2A, IL2RA, ERBB2, GO:0042130~negative regulation of T 0.88888888 1352 1.01E-0 12 5.58E-10 CD274, CTLA4, PAWR, FOXP3, 466 27 12.9022413 1.70E-06 1.01E-08 cell proliferation 9 8 6 PDCD1LG2, IL10, TGFB1
TNFRSF12A, SIPA1, PML, TP63, SFN,
TGFB1, TGFB2, CDKN2A, CD44, APOE,
2.07407407 PTK2B, CTGF, PRSS2, ILK, CAMK2D, 1352 4.18990310 1.03E-0 GO:0001558~regulation of cell growth 28 5.68E-10 466 194 1.73E-06 1.03E-08 4 IP6K2, IL7, SMAD4, TP53, SMAD3, RB1, 8 2 6
ESR2, TP73, CISH, CDKN1A, CDKN1B,
EP300, IL2
CRTAM, IL6, TNF, PANX1, TGFB3, GO:0050714~positive regulation of 1.03703703 1352 9.91269758 1.04E-0 14 5.79E-10 TGFB1, IL10, TGFB2, P2RX7, SAA1, 466 41 1.77E-06 1.04E-08 protein secretion 7 8 2 6 IFNG, PYCARD, IL1A, IL2
GO:0006928~cell motion 46 3.40740740 6.24E-10 PVR, TNF, PTGS2, TNFRSF12A, ERBB2, 466 475 1352 2.81133047 1.90E-06 1.11E-08 1.13E-0 7 PAX6, PRKDC, KITLG, PAX3, KIT, 8 2 6
TNFSF12, PRKG1, GLI2, PTEN, TGFB1,
IL10, TGFB2, VCAM1, EDNRB, GAB2,
CD44, PVRL1, CTGF, PTK2B, SAA1,
IFNG, IL1B, SH2B1, SYK, APC, IL6,
EGR2, EFNB1, TBX1, ESR2, VASP,
STAT3, SMO, CCR6, CD34, FOXG1,
TXN, SIX1, LRP6, FOXC1, NGFR
NOG, FOXA2, PAX6, PRKDC, TP63,
FGF10, ZBTB16, ZEB1, GLI2, GLI3,
AXIN1, PITX2, APC, BMP4, MLL, EGR2, GO:0007389~pattern specification 2.44444444 1352 3.58798283 1.27E-0 33 7.06E-10 EFNB1, SMAD5, SMAD4, TBX1, SMAD2, 466 267 2.15E-06 1.25E-08 process 4 8 3 6 SMAD1, SMO, NOTCH1, CRKL, EP300,
MEOX2, VEGFA, SIX1, FOXG1, LRP6,
ROR2, PBX1
CAV1, IL6, CARD9, TNF, FGF9, ERBB2,
GO:0043408~regulation of MAPKKK 1.55555555 TLR3, TLR4, TP73, TGFB2, MAP3K7, 1352 5.59294404 1.35E-0 21 7.49E-10 466 109 2.29E-06 1.32E-08 cascade 6 P2RX7, NOD1, PTK2B, RIPK1, ILK, 8 9 6
RIPK2, IL1B, AXIN1, APC, SYK
GO:0002768~immune BCL10, CD247, TLR2, KLRK1, MALT1, 1.03703703 1352 9.67668097 1.47E-0 response-regulating cell surface receptor 14 8.13E-10 CD40, MAP3K7, BTLA, UBE2N, CD19, 466 42 2.48E-06 1.42E-08 7 8 3 6 signaling pathway IKBKG, RIPK2, TRAF6, SYK
BMP4, IL6, BMP2, EGR2, SMAD5,
1.33333333 TGFB3, SMAD3, SMAD1, SOX9, TGFB1, 1352 6.69924067 1.60E-0 GO:0030278~regulation of ossification 18 8.85E-10 466 78 2.70E-06 1.54E-08 3 TGFB2, P2RX7, PTK2B, DLX5, PBX1, 8 3 6
RUNX2, TWIST2, APC BTLA, CARD11, CDKN1A, CDKN2A, GO:0030888~regulation of B cell 0.88888888 1352 12.4414469 1.61E-0 12 8.91E-10 IL5, IL7, TICAM1, PAWR, CD40, 466 28 2.72E-06 1.54E-08 proliferation 9 8 7 6 INPP5D, IL10, IL2
CIITA, IL6, BMP2, TNF, THRA, IL5,
FOXA2, RXRA, TP53, TGFB3, SMAD3, GO:0032583~regulation of gene-specific 1.70370370 1352 4.98276856 1.75E-0 23 9.72E-10 NFKBIA, PRKDC, SMAD2, NFKB1, 466 134 2.96E-06 1.67E-08 transcription 4 8 1 6 ESR2, FOXP3, IL10, CDKN1C, VDR,
NOTCH1, CDKN1B, IRF4
BMP2, TNFRSF12A, RELA, TGFB3,
GO:0010720~positive regulation of cell 1.25925925 SMAD4, PAX6, SMAD3, SMAD2, KIT, 1352 7.15232941 1.89E-0 17 1.05E-09 466 69 3.20E-06 1.80E-08 development 9 SMAD1, TGFB1, TGFB2, SMO, NOTCH1, 8 5 6
ILK, FOXG1, NGFR
BMP2, NOG, EFNB1, KITLG, TBX1,
GO:0048762~mesenchymal cell 1.11111111 PAX3, SOX9, TGFB1, TGFB2, SMO, 1352 8.53824791 1.92E-0 15 1.07E-09 466 51 3.25E-06 1.82E-08 differentiation 1 EDNRB, NOTCH1, HAND2, FOXC1, 8 7 6
NFATC1
BMP2, NOG, EFNB1, KITLG, TBX1,
GO:0014031~mesenchymal cell 1.11111111 PAX3, SOX9, TGFB1, TGFB2, SMO, 1352 8.53824791 1.92E-0 15 1.07E-09 466 51 3.25E-06 1.82E-08 development 1 EDNRB, NOTCH1, HAND2, FOXC1, 8 7 6
NFATC1
IL2RA, SOCS3, RELA, SOCS1, CTLA4,
GO:0048585~negative regulation of 1.48148148 ESR2, IL7R, FOXP3, IRS1, IL10, TGFB1, 1352 5.80600858 1.95E-0 20 1.08E-09 466 100 3.29E-06 1.83E-08 response to stimulus 1 TGFB2, IRAK3, TNFRSF1B, SAA1, 8 4 6
APOE, IL1B, PTPN1, INPP5D, IL2
GO:0034097~response to cytokine 1.33333333 CIITA, IRAK2, IRAK1, IL1R1, PTGS2, 1352 6.61444015 1.97E-0 18 1.09E-09 466 79 3.33E-06 1.84E-08 stimulus 3 SOCS3, RELA, SOCS1, PML, 8 9 6 CALCOCO2, STAT1, STAT3, IRAK3,
FOS, MYD88, RIPK1, RIPK2, GHR
GO:0032655~regulation of interleukin-12 0.74074074 IRAK3, REL, CD40LG, RELA, IFNG, 1352 17.0764958 2.13E-0 10 1.18E-09 466 17 3.60E-06 1.98E-08 production 1 IRF1, TLR4, CD40, TRAF6, IL10 8 3 6
MAVS, IL6, CARD9, TNF, HCK, TLR2,
TLR3, TLR4, IL10, S100A12, TLR9, GO:0042742~defense response to 1.55555555 1352 5.44313304 2.23E-0 21 1.24E-09 TNFRSF1A, P2RX7, NOD1, DEFA1B, 466 112 3.77E-06 2.06E-08 bacterium 6 8 7 6 DEFA5, DEFA4, IFNG, DEFA3, RIPK2,
DEFA1, LBP
BMP2, NOG, EFNB1, KITLG, TBX1,
1.11111111 PAX3, SOX9, TGFB1, TGFB2, SMO, 1352 8.37405084 2.55E-0 GO:0060485~mesenchyme development 15 1.41E-09 466 52 4.31E-06 2.34E-08 1 EDNRB, NOTCH1, HAND2, FOXC1, 8 2 6
NFATC1
IL2RA, ERBB2, CTLA4, PAWR, FOXP3,
GO:0050866~negative regulation of cell 1.18518518 PDCD1LG2, TGFB1, IL10, BTLA, CBLB, 1352 7.61443748 2.63E-0 16 1.46E-09 466 61 4.44E-06 2.40E-08 activation 5 CDKN2A, APOE, CD274, INPP5D, FAS, 8 7 6
IL2
TRAF2, TNF, ERBB2, TGFB3, TLR3,
KITLG, KIT, TGFB1, TGFB2, MAP3K7,
GO:0033674~positive regulation of 2.22222222 PTK2B, ILK, IL1B, TRAF6, GHR, SYK, 1352 3.77013544 2.77E-0 30 1.54E-09 466 231 4.68E-06 2.52E-08 kinase activity 2 EGFR, IRAK1, MALT1, TAB1, IRS1, 8 4 6
CISH, GH1, P2RX7, TNFRSF10B, PRLR,
RIPK1, CD81, IKBKG, IL2
BMP4, TNF, NFKBIE, NFKBIB, TGFB3, GO:0042306~regulation of protein import 1.03703703 1352 9.23683183 2.80E-0 14 1.55E-09 SMAD4, NFKBIA, SMAD3, CDH1, GLI3, 466 44 4.74E-06 2.53E-08 into nucleus 7 8 8 6 TGFB1, IL10, SMO, EDA BMP4, TNF, NFKBIE, NFKBIB, TGFB3,
GO:0032386~regulation of intracellular 1.25925925 SMAD4, SMAD3, NFKBIA, CDH1, GLI3, 1352 6.95085534 2.98E-0 17 1.65E-09 466 71 5.03E-06 2.68E-08 transport 9 TGFB1, IL10, SMO, CDKN2A, NEDD4, 8 7 6
IL1B, EDA
BMP4, TNF, NFKBIE, NFKBIB, TGFB3, GO:0033157~regulation of intracellular 1.11111111 1352 8.21604988 3.36E-0 15 1.86E-09 SMAD4, NFKBIA, SMAD3, CDH1, GLI3, 466 53 5.68E-06 3.00E-08 protein transport 1 8 3 6 TGFB1, IL10, SMO, IL1B, EDA
BMP4, BMP2, FOXA2, IL7, SMAD5,
TP53, SMAD4, PAX6, JAG2, PRKDC, 1.70370370 1352 4.80353228 3.59E-0 GO:0045165~cell fate commitment 23 1.99E-09 FGF10, SMAD2, TBX1, PAX3, SMAD1, 466 139 6.07E-06 3.19E-08 4 8 1 6 GLI2, SOX9, GLI3, TGFB2, SMO,
NOTCH1, SIX1, RUNX2
BMP4, SMO, TNF, NEDD4, SMAD4, GO:0032388~positive regulation of 0.88888888 1352 11.6120171 3.84E-0 12 2.13E-09 TGFB3, SMAD3, IL1B, CDH1, EDA, 466 30 6.49E-06 3.40E-08 intracellular transport 9 8 7 6 GLI3, TGFB1
FGFR2, FGFR1, TNFRSF12A, SIPA1,
PML, TGFB3, TP63, SFN, IL7R, TGFB1,
2.07407407 TGFB2, CDKN2A, PTK2B, PRSS2, ILK, 1352 3.94583107 3.97E-0 GO:0008361~regulation of cell size 28 2.20E-09 466 206 6.71E-06 3.49E-08 4 IP6K2, RARG, IL7, SMAD4, TP53, 8 6 6
SMAD3, RB1, ESR2, TP73, CDKN1A,
CDKN1B, EP300, IL2
BMP4, BMP2, TGFB3, JAG2, TP63, GLI2, 1.11111111 1352 8.06390081 4.39E-0 GO:0042476~odontogenesis 15 2.44E-09 GLI3, TGFB1, TGFB2, SMO, FOXC1, 466 54 7.43E-06 3.85E-08 1 8 1 6 COL1A1, TRAF6, EDA, CHUK
GO:0051250~negative regulation of 1.11111111 IL2RA, ERBB2, CTLA4, PAWR, FOXP3, 1352 8.06390081 4.39E-0 15 2.44E-09 466 54 7.43E-06 3.85E-08 lymphocyte activation 1 PDCD1LG2, TGFB1, IL10, BTLA, CBLB, 8 1 6 CDKN2A, CD274, INPP5D, FAS, IL2
IL2RA, ERBB2, CTLA4, PAWR, FOXP3,
GO:0002683~negative regulation of 1.33333333 IL7R, PDCD1LG2, TGFB1, IL10, TGFB2, 1352 6.29567195 4.43E-0 18 2.45E-09 466 83 7.48E-06 3.86E-08 immune system process 3 BTLA, IRAK3, CBLB, CDKN2A, CD274, 8 8 6
FAS, INPP5D, IL2
BCL10, IL18, TLR4, PAWR, IFNAR1, 1.03703703 1352 8.83523045 5.16E-0 GO:0001816~cytokine production 14 2.86E-09 IRF9, IRAK4, MYD88, NOD1, REL, IRF3, 466 46 8.72E-06 4.47E-08 7 8 3 6 CD226, PTAFR, CD28
TRAF2, TNF, ERBB2, TGFB3, TLR3,
KITLG, KIT, TGFB1, TGFB2, MAP3K7,
GO:0045860~positive regulation of 2.14814814 PTK2B, ILK, IL1B, TRAF6, GHR, SYK, 1352 3.77520737 5.32E-0 29 2.95E-09 466 223 9.00E-06 4.59E-08 protein kinase activity 8 EGFR, IRAK1, MALT1, TAB1, CISH, 8 5 6
GH1, P2RX7, TNFRSF10B, PRLR, RIPK1,
CD81, IKBKG, IL2
TRAF2, TNF, ERBB2, TGFB3, TLR3,
KITLG, KIT, TGFB1, TGFB2, MAP3K7,
GO:0051347~positive regulation of 2.22222222 PTK2B, ILK, IL1B, TRAF6, GHR, SYK, 1352 3.62875536 6.77E-0 30 3.75E-09 466 240 1.14E-05 5.81E-08 transferase activity 2 EGFR, IRAK1, MALT1, TAB1, IRS1, 8 5 6
CISH, GH1, P2RX7, TNFRSF10B, PRLR,
RIPK1, CD81, IKBKG, IL2
IRAK3, CARD9, TICAM1, SMAD3, 0.81481481 1352 12.7732188 7.76E-0 GO:0043331~response to dsRNA 11 4.30E-09 NFKBIA, TLR3, RIPK2, IRF3, SMAD2, 466 25 1.31E-05 6.62E-08 5 8 8 6 SMAD1, STAT1
IL2RA, ERBB2, CTLA4, PAWR, FOXP3, GO:0002695~negative regulation of 1.11111111 1352 7.63948497 9.48E-0 15 5.25E-09 PDCD1LG2, TGFB1, IL10, BTLA, CBLB, 466 57 1.60E-05 8.05E-08 leukocyte activation 1 8 9 6 CDKN2A, CD274, INPP5D, FAS, IL2 GO:0002460~adaptive immune response BCL10, CRTAM, CD8A, IL18, RELB,
based on somatic recombination of 1.25925925 TLR4, NFKB2, HLA-DMA, TLR8, IL10, 1352 6.40923025 1.05E-0 17 5.83E-09 466 77 1.78E-05 8.88E-08 immune receptors built from 9 MYD88, CD40LG, VEGFA, INPP5D, FAS, 8 5 5
immunoglobulin superfamily domains TRAF6, HLA-DRA
BCL10, CRTAM, CD8A, IL18, RELB,
1.25925925 TLR4, NFKB2, HLA-DMA, TLR8, IL10, 1352 6.40923025 1.05E-0 GO:0002250~adaptive immune response 17 5.83E-09 466 77 1.78E-05 8.88E-08 9 MYD88, CD40LG, VEGFA, INPP5D, FAS, 8 5 5
TRAF6, HLA-DRA
PVR, TNF, TNFRSF12A, PAX6, PRKDC,
KITLG, PAX3, KIT, TNFSF12, PRKG1,
PTEN, TGFB1, IL10, TGFB2, VCAM1, 2.51851851 1352 3.21505361 1.12E-0 GO:0051674~localization of cell 34 6.21E-09 EDNRB, GAB2, CD44, CTGF, PTK2B, 466 307 1.89E-05 9.43E-08 9 8 3 5 SAA1, IFNG, IL1B, SYK, APC, IL6,
EFNB1, TBX1, ESR2, SMO, CD34, SIX1,
LRP6, FOXC1
PVR, TNF, TNFRSF12A, PAX6, PRKDC,
KITLG, PAX3, KIT, TNFSF12, PRKG1,
PTEN, TGFB1, IL10, TGFB2, VCAM1, 2.51851851 1352 3.21505361 1.12E-0 GO:0048870~cell motility 34 6.21E-09 EDNRB, GAB2, CD44, CTGF, PTK2B, 466 307 1.89E-05 9.43E-08 9 8 3 5 SAA1, IFNG, IL1B, SYK, APC, IL6,
EFNB1, TBX1, ESR2, SMO, CD34, SIX1,
LRP6, FOXC1
GO:0032570~response to progesterone 0.74074074 TXNIP, FOS, CAV1, SOCS3, RELA, 1352 14.5150214 1.34E-0 10 7.44E-09 466 20 2.27E-05 1.12E-07 stimulus 1 ERBB2, SOCS1, TGFB3, TGFB1, TGFB2 8 6 5
GO:0002708~positive regulation of 0.88888888 MAP3K7, PVR, TRAF2, P2RX7, CRTAM, 1352 1.78E-0 12 9.84E-09 466 34 10.2458975 3.00E-05 1.48E-07 lymphocyte mediated immunity 9 TAP2, STAT5B, KLRK1, IL1B, MALT1, 8 5 TRAF6, CD226
MAP3K7, PVR, TRAF2, P2RX7, CRTAM, GO:0002705~positive regulation of 0.88888888 1352 1.78E-0 12 9.84E-09 TAP2, STAT5B, KLRK1, IL1B, MALT1, 466 34 10.2458975 3.00E-05 1.48E-07 leukocyte mediated immunity 9 8 5 TRAF6, CD226
BMP4, BMP2, NOG, FGF9, SMAD5, 0.96296296 1352 8.98548947 1.84E-0 GO:0001649~osteoblast differentiation 13 1.02E-08 SMAD3, SMAD1, GLI2, CBFB, PTHLH, 466 42 3.12E-05 1.53E-07 3 8 5 5 SMO, COL1A1, RUNX2
TRAF2, CAV1, TNF, ERBB2, PML,
TGFB3, TLR3, KITLG, KIT, TGFB1,
TGFB2, MAP3K7, EDNRB, VDR,
CDKN2A, NOD1, PTK2B, APOE, ILK,
GO:0043085~positive regulation of 3.40740740 IFNG, PYCARD, IL1B, TRAF6, MYC, 1352 2.56804225 1.95E-0 46 1.08E-08 466 520 3.29E-05 1.61E-07 catalytic activity 7 GHR, SYK, EGFR, IRAK1, TP53, SMAD3, 8 8 5
MALT1, TAB1, STAT1, IRS1, NLRP1,
CISH, UBE2N, PTHLH, GH1, P2RX7,
TNFRSF10B, PRLR, RIPK1, IKBKG,
CD81, IL2
BMP4, BCL10, BMP2, FOXA2, SMAD4,
1.55555555 TP63, FGF10, PAX3, GLI2, GLI3, VASP, 1352 4.80024331 2.14E-0 GO:0035239~tube morphogenesis 21 1.19E-08 466 127 3.62E-05 1.76E-07 6 MAP3K7, NOTCH1, CD44, HAND2, ILK, 8 7 5
VEGFA, SIX1, TFAP2A, PBX1, TRAF6
GO:0070304~positive regulation of 0.74074074 MAP3K7, NOD1, CARD9, TNF, TLR3, 1352 13.8238299 2.28E-0 stress-activated protein kinase signaling 10 1.26E-08 466 21 3.85E-05 1.86E-07 1 IL1B, RIPK2, TLR4, AXIN1, TGFB2 8 6 5 pathway
GO:0002709~regulation of T cell 0.74074074 MAP3K7, PVR, TRAF2, P2RX7, TAP2, 1352 13.8238299 2.28E-0 10 1.26E-08 466 21 3.85E-05 1.86E-07 mediated immunity 1 IL1B, MALT1, TRAF6, IL7R, FOXP3 8 6 5 FGFR2, FGFR1, FGF8, CD8A, FGF9,
ERBB2, STAT5B, FGF10, KIT, PTEN,
GO:0007169~transmembrane receptor 2.07407407 TGFB1, IGF1R, PTK2B, CTGF, 1352 3.62875536 2.49E-0 28 1.38E-08 466 224 4.21E-05 2.03E-07 protein tyrosine kinase signaling pathway 4 RAPGEF1, GHR, EGFR, TXNIP, IRS2, 8 5 5
CBL, IRS1, STAT3, GH1, PRLR, VEGFA,
ROR2, FOXC1, PTPN1
CAV1, TNF, TNFRSF12A, PML, TGFB3,
FGF10, KIT, TGFB1, TGFB2, ILK, IL1B, GO:0051130~positive regulation of 1.85185185 1352 4.00967443 2.49E-0 25 1.38E-08 NEDD4L, IL1A, APC, CD28, CBL, 466 181 4.22E-05 2.02E-07 cellular component organization 2 8 6 5 SMAD4, SMAD3, SMAD2, SMAD1,
FOXP3, UBE2N, P2RX7, CDKN1B, NGFR
GO:0031663~lipopolysaccharide-mediate 0.59259259 IRAK2, IRAK1, TICAM1, NFKBIA, 1352 21.1127584 2.86E-0 8 1.59E-08 466 11 4.84E-05 2.31E-07 d signaling pathway 3 RIPK2, IRF3, LBP, STAT1 8 9 5
GO:0043330~response to exogenous 0.59259259 IRAK3, CARD9, TICAM1, NFKBIA, 1352 21.1127584 2.86E-0 8 1.59E-08 466 11 4.84E-05 2.31E-07 dsRNA 3 TLR3, RIPK2, IRF3, STAT1 8 9 5
GO:0042089~cytokine biosynthetic 0.66666666 IRF9, BCL10, NOD1, MYD88, IL18, IRF3, 1352 16.3293991 3.34E-0 9 1.85E-08 466 16 5.65E-05 2.68E-07 process 7 PAWR, IFNAR1, CD28 8 4 5
RNF144B, UBE2A, LRSAM1, DZIP3,
UBE4A, CBL, CDC34, PARK2, UBOX5, 1.48148148 1352 3.95E-0 GO:0016567~protein ubiquitination 20 2.19E-08 UBE3C, UBE2B, UBE2N, FBXW7, 466 119 4.87899881 6.68E-05 3.15E-07 1 8 5 NEDD4, TRIM32, FBXO4, NEDD4L,
TRAF6, TRIP12, RNF41
RNF144B, UBE2A, LRSAM1, DZIP3,
GO:0032446~protein modification by 1.55555555 UBE4A, CBL, CDC34, PARK2, UBOX5, 1352 4.61841591 4.21E-0 21 2.33E-08 466 132 7.12E-05 3.34E-07 small protein conjugation 6 UBE3C, UBE2B, UBE2N, FBXW7, 8 9 5
NEDD4, TRIM32, UBA3, FBXO4, NEDD4L, TRAF6, TRIP12, RNF41
CAV1, PTGS2, ERBB2, TLR2, CDH1,
PTEN, TGFB1, FOS, ATG5, PTK2B, IL1B,
APC, TXNIP, CARD9, SOCS3, RELA, 1352 3.62875536 4.77E-0 GO:0042493~response to drug 27 2 2.65E-08 466 216 8.07E-05 3.77E-07 SOCS1, TP53, SMAD1, STAT1, UBE2B, 8 5 5
STAT3, CDKN1A, P2RX7, BLMH, EP300,
IKBKB
GO:0046330~positive regulation of JNK 0.66666666 MAP3K7, NOD1, CARD9, TNF, TLR3, 1352 15.3688462 6.13E-0 9 3.40E-08 466 17 1.04E-04 4.82E-07 cascade 7 IL1B, RIPK2, TLR4, AXIN1 8 5 5
0.66666666 IRF9, BCL10, NOD1, MYD88, IL18, IRF3, 1352 15.3688462 6.13E-0 GO:0042107~cytokine metabolic process 9 3.40E-08 466 17 1.04E-04 4.82E-07 7 PAWR, IFNAR1, CD28 8 5 5
NOG, FOXA2, FGF9, PAX6, TGFB3,
PRKDC, CDH1, KEAP1, PAX3, ZEB1,
GLI2, GLI3, CUL3, MAP3K7, CHD7, GO:0043009~chordate embryonic 2.51851851 1352 2.98193794 7.15E-0 34 3.96E-08 HAND2, TRAF6, BMP4, BCL10, TP53, 466 331 1.21E-04 5.59E-07 development 9 8 3 5 SMAD2, TBX1, TAB1, VASP, SMO,
MSX1, EP300, MEOX2, SIX1, TFAP2A,
ROR2, PBX1, FOXC1, COL1A1
GO:0032647~regulation of 0.51851851 MAVS, DDX58, TLR3, TLR7, TLR8, IL10, 1352 25.4012875 7.61E-0 7 4.22E-08 466 8 1.29E-04 5.93E-07 interferon-alpha production 9 TLR9 8 5 5
NOG, FOXA2, FGF9, PAX6, TGFB3,
PRKDC, CDH1, KEAP1, PAX3, ZEB1,
GO:0009792~embryonic development 2.51851851 GLI2, GLI3, CUL3, MAP3K7, CHD7, 1352 8.88E-0 34 4.92E-08 466 334 2.95515407 1.50E-04 6.88E-07 ending in birth or egg hatching 9 HAND2, TRAF6, BMP4, BCL10, TP53, 8 5
SMAD2, TBX1, TAB1, VASP, SMO,
MSX1, EP300, MEOX2, SIX1, TFAP2A, ROR2, PBX1, FOXC1, COL1A1
GO:0002429~immune MAP3K7, UBE2N, BCL10, CD19, IKBKG, 0.88888888 1352 8.93232089 8.90E-0 response-activating cell surface receptor 12 4.93E-08 CD247, TLR2, KLRK1, RIPK2, MALT1, 466 39 1.51E-04 6.87E-07 9 8 8 5 signaling pathway TRAF6, SYK
BMP4, BCL10, BMP2, SMAD4, JAG2,
GO:0002009~morphogenesis of an 1.33333333 TP63, PAX3, GLI2, GLI3, VASP, 1352 5.17367101 9.82E-0 18 5.44E-08 466 101 1.66E-04 7.54E-07 epithelium 3 MAP3K7, CD44, ILK, SIX1, TFAP2A, 8 5 5
PBX1, TRAF6, CHUK
GO:0002718~regulation of cytokine 0.66666666 MAP3K7, TRAF2, BCL10, IRAK3, TNF, 1352 14.5150214 1.07E-0 9 5.93E-08 466 18 1.81E-04 8.19E-07 production during immune response 7 MALT1, TRAF6, FOXP3, IL10 8 6 4
EGFR, CSF2, IL3, CAV1, IL6, IL5, GO:0050730~regulation of 1.11111111 1352 6.40368593 1.07E-0 15 5.95E-08 SOCS1, KITLG, TLR4, GH1, CD81, IFNG, 466 68 1.81E-04 8.17E-07 peptidyl-tyrosine phosphorylation 1 8 8 4 SYK, GHR, IL2
TNF, TLR2, PML, TGFB3, TP63, SFN,
TNFSF12, PTEN, TGFB1, CUL3, VDR,
NOD1, CDKN2A, APOE, TICAM1, 2.44444444 1352 2.99372317 1.08E-0 GO:0006917~induction of apoptosis 33 5.96E-08 PYCARD, FAS, TRAF6, MYC, TRAF3, 466 320 1.82E-04 8.15E-07 4 8 6 4 BCL10, CRTAM, TP53, SMAD3, STAT1,
NLRP1, TP73, CDKN1A, TNFRSF10B,
CDKN1B, RIPK1, IKBKG, NGFR
TNF, TLR2, PML, TGFB3, TP63, SFN,
TNFSF12, PTEN, TGFB1, CUL3, VDR,
GO:0012502~induction of programmed 2.44444444 NOD1, CDKN2A, APOE, TICAM1, 1352 2.98439693 1.16E-0 33 6.41E-08 466 321 1.96E-04 8.73E-07 cell death 4 PYCARD, FAS, TRAF6, MYC, TRAF3, 8 6 4
BCL10, CRTAM, TP53, SMAD3, STAT1,
NLRP1, TP73, CDKN1A, TNFRSF10B, CDKN1B, RIPK1, IKBKG, NGFR
FOXA2, PAX6, JAG2, TP63, SFN, PAX3,
GLI2, GLI3, MAP3K7, CD44, ILK,
TRAF6, CHUK, TXNIP, BMP4, BCL10, 1352 3.45291259 1.32E-0 GO:0060429~epithelium development 27 2 7.34E-08 466 227 2.24E-04 9.94E-07 BMP2, SMAD4, VASP, PTHLH, IRF6, 8 4 4
DLX5, SIX1, VEGFA, TFAP2A,
MADCAM1, PBX1
STK11, TP53, PML, SMAD3, RB1, TP73,
1.33333333 TGFB1, TGFB2, CUL3, CDKN1C, 1352 5.07321138 1.32E-0 GO:0007050~cell cycle arrest 18 7.34E-08 466 103 2.24E-04 9.91E-07 3 CDKN1A, CDKN2A, CDKN1B, IRF6, 8 4 4
ILK, IFNG, MYC, APC
GO:0007250~activation of 0.59259259 MAP3K7, TRAF2, IRAK1, TNFRSF10B, 1352 1.40E-0 8 7.78E-08 466 13 17.8646418 2.37E-04 1.04E-06 NF-kappaB-inducing kinase activity 3 IKBKG, TLR3, MALT1, TRAF6 8 4
CAV1, TNFRSF12A, FGF9, IL18, FGF10,
TNFSF12, PTEN, TGFB2, MAP3K7,
2.07407407 CHD7, CUL7, ATG5, CD44, APOE, 1352 3.31771919 1.66E-0 GO:0001568~blood vessel development 28 9.18E-08 466 245 2.80E-04 1.23E-06 4 PTK2B, HAND2, CTGF, IL1B, ERAP1, 8 1 4
BMP4, TBX1, SMO, NOTCH1, CRKL,
MEOX2, VEGFA, FOXC1, COL1A1
BMP4, CSF2, TNF, RELB, SMAD5, PML,
1.25925925 RB1, ZBTB16, KIT, CBFB, TGFB1, 1352 5.30656698 1.76E-0 GO:0030099~myeloid cell differentiation 17 9.78E-08 466 93 2.98E-04 1.30E-06 9 TNFSF11, IRF8, VEGFA, IRF4, TRAF6, 8 5 4
CHUK
GO:0035272~exocrine system 0.66666666 EGFR, PAX6, TGFB3, SOX4, FGF10, 1352 13.7510729 1.79E-0 9 9.94E-08 466 19 3.03E-04 1.32E-06 development 7 FOXC1, EDA, TGFB1, TGFB2 8 6 4
GO:0050868~negative regulation of T 12 0.88888888 1.15E-07 BTLA, CBLB, CDKN2A, IL2RA, ERBB2, 466 42 1352 8.29429797 3.50E-04 1.52E-06 2.07E-0 cell activation 9 CD274, CTLA4, PAWR, FOXP3, 8 7 4
PDCD1LG2, IL10, TGFB1
GO:0002637~regulation of 0.74074074 IL6, TNF, CD40LG, IFNG, TNFSF12, 1352 11.1654011 2.08E-0 10 1.15E-07 466 26 3.51E-04 1.51E-06 immunoglobulin production 1 CD40, TRAF6, IL10, TGFB1, IL2 8 2 4
BCL10, RELA, CD160, KIR2DS1, TRAT1, 1.03703703 1352 6.66263280 2.08E-0 GO:0006968~cellular defense response 14 1.15E-07 LILRB2, KLRG1, CD19, CCR6, TAP2, 466 61 3.51E-04 1.51E-06 7 8 1 4 CCR2, LBP, KIR3DL2, TYROBP
TNF, PANX1, PTGS1, TGFB3, IL10,
TGFB1, TGFB2, CHD7, SAA1, IFNG,
1.85185185 PYCARD, IL1B, RAPGEF4, TRAF6, 1352 3.59282709 2.12E-0 GO:0051046~regulation of secretion 25 1.17E-07 466 202 3.58E-04 1.53E-06 2 CAMK2A, IL1A, SYK, IL6, CRTAM, 8 4 4
PARK2, CD40, FOXP3, P2RX7, CD40LG,
IL2
0.51851851 IRF7, TLR2, SMAD3, TLR3, TLR4, TLR7, 1352 22.5789222 2.22E-0 GO:0052200~response to host defenses 7 1.23E-07 466 9 3.75E-04 1.60E-06 9 TGFB1 8 7 4
0.51851851 IRF7, TLR2, SMAD3, TLR3, TLR4, TLR7, 1352 22.5789222 2.22E-0 GO:0075136~response to host 7 1.23E-07 466 9 3.75E-04 1.60E-06 9 TGFB1 8 7 4
GO:0052173~response to defenses of 0.51851851 IRF7, TLR2, SMAD3, TLR3, TLR4, TLR7, 1352 22.5789222 2.22E-0 other organism during symbiotic 7 1.23E-07 466 9 3.75E-04 1.60E-06 9 TGFB1 8 7 4 interaction
GO:0000060~protein import into nucleus, 0.81481481 TNF, IFNG, PML, TGFB3, TP53, NFKBIA, 1352 9.39207270 2.36E-0 11 1.31E-07 466 34 3.98E-04 1.69E-06 translocation 5 FGF10, PRL, GLI3, TGFB1, TGFB2 8 9 4
E2F1, TNF, PTGS2, SIPA1, STAT5B,
2.44444444 PML, SFN, PTEN, TGFB1, TGFB2, 1352 2.89423388 2.36E-0 GO:0051726~regulation of cell cycle 33 1.31E-07 466 331 3.99E-04 1.68E-06 4 CDKN2A, CUL7, FBXO6, CAMK2D, 8 6 4
HECTD3, IL1B, MYC, IL1A, CD28, APC, BMP4, EGFR, BMP2, TP53, SMAD3, RB1,
CDKN1C, CDKN1A, CDKN1B, UBA3,
FOXG1, FOXC1, NGFR
CAV1, TNFRSF12A, FGF9, IL18, FGF10,
TNFSF12, PTEN, TGFB2, MAP3K7,
2.07407407 CHD7, CUL7, ATG5, CD44, APOE, 1352 3.23841116 2.75E-0 GO:0001944~vasculature development 28 1.53E-07 466 251 4.65E-04 1.96E-06 4 PTK2B, HAND2, CTGF, IL1B, ERAP1, 8 2 4
BMP4, TBX1, SMO, NOTCH1, CRKL,
MEOX2, VEGFA, FOXC1, COL1A1
NOG, FOXA2, TNFRSF12A, PAX6,
TGFB3, KIT, GLI2, TGFB1, TGFB2,
GO:0060284~regulation of cell 1.85185185 APOE, ILK, BMP4, BMP2, RELA, 1352 3.54024913 2.80E-0 25 1.55E-07 466 205 4.73E-04 1.98E-06 development 2 SMAD4, TP53, SMAD3, SMAD2, SMAD1, 8 6 4
SMO, NOTCH1, SIX1, FOXG1, PBX1,
NGFR
IRS2, CAV1, ERBB2, STAT5B, TGFB3, GO:0030879~mammary gland 1.03703703 1352 6.45112064 3.11E-0 14 1.72E-07 GLI2, GLI3, IRS1, TGFB1, PTHLH, 466 63 5.26E-04 2.19E-06 development 7 8 9 4 IGF1R, PRLR, IRF6, PRL
BMP4, CAV1, IL6, TNF, PTGS2, RXRA, GO:0031960~response to corticosteroid 1.18518518 1352 5.46447866 3.14E-0 16 1.74E-07 PTGS1, IL1RN, IL10, FOS, CDKN1A, 466 85 5.31E-04 2.20E-06 stimulus 5 8 7 4 EP300, IL1B, FAS, COL1A1, GHR
BMP4, TXNIP, PTGS2, SOCS3, STAT5B, GO:0032355~response to estradiol 0.96296296 1352 6.98871403 3.93E-0 13 2.18E-07 SOCS1, PTEN, STAT3, TGFB1, GH1, 466 54 6.64E-04 2.75E-06 stimulus 3 8 6 4 IL1B, RARA, GHR
GO:0010605~negative regulation of E2F1, THRA, TGFB3, TP63, NFKB1, 1352 2.13572522 3.95E-0 54 4 2.19E-07 466 734 6.68E-04 2.75E-06 macromolecule metabolic process PAX3, ZEB1, PAWR, GLI2, GLI3, TGFB1, 8 8 4 IL10, CDKN2A, ATG5, MYC, TWIST2,
CIITA, EGR1, RARG, RELA, RXRA,
SOCS1, TP53, RB1, TRAT1, MSX1, ASB1,
CAV1, TNF, PML, ZBTB16, SOX9,
IRAK3, VDR, INPP5D, RUNX2, BMP4,
IL6, BMP2, SMAD4, SMAD3, SMAD2,
SMAD1, FOXP3, STAT3, CDKN1C,
CDKN1B, NEDD4, IRF7, IRF8, UBA3,
IRF2, IL2, ADAR
GO:0046425~regulation of JAK-STAT 0.81481481 CSF2, GH1, IL3, CAV1, IL6, IL5, SOCS1, 1352 8.87029089 4.29E-0 11 2.38E-07 466 36 7.25E-04 2.97E-06 cascade 5 IFNG, PRL, GHR, IL2 8 2 4
NOG, THRA, TGFB3, TBX1, ZEB1,
GO:0048705~skeletal system 1.33333333 SOX9, GLI3, TGFB1, PTHLH, P2RX7, 1352 4.66554261 4.66E-0 18 2.58E-07 466 112 7.87E-04 3.21E-06 morphogenesis 3 CTGF, SIX1, TFAP2A, ROR2, COL1A1, 8 2 4
RUNX2, MYC, GHR
GO:0032479~regulation of type I 0.59259259 MAVS, DDX58, TICAM1, TLR3, TLR7, 1352 15.4826895 4.95E-0 8 2.75E-07 466 15 8.37E-04 3.40E-06 interferon production 3 TLR8, IL10, TLR9 8 6 4
GO:0002711~positive regulation of T cell 0.59259259 MAP3K7, PVR, TRAF2, P2RX7, TAP2, 1352 15.4826895 4.95E-0 8 2.75E-07 466 15 8.37E-04 3.40E-06 mediated immunity 3 IL1B, MALT1, TRAF6 8 6 4
BMP4, NOG, EGR2, MLL, FOXA2,
SMAD4, PAX6, PRKDC, TP63, SMAD2, 1.77777777 1352 3.53665497 5.35E-0 GO:0003002~regionalization 24 2.96E-07 TBX1, ZBTB16, GLI2, GLI3, SMO, 466 197 9.03E-04 3.66E-06 8 8 5 4 NOTCH1, CRKL, EP300, MEOX2,
FOXG1, LRP6, ROR2, PBX1, APC
GO:0002274~myeloid leukocyte 0.88888888 CSF2, RELB, TICAM1, TLR1, TLR2, 1352 7.57305467 5.70E-0 12 3.16E-07 466 46 9.63E-04 3.89E-06 activation 9 TLR3, TLR4, IRF4, LBP, TRAF6, TLR7, 8 4 4 TGFB1
NOG, FGF9, ERBB2, PAX6, TGFB3,
JAG2, FGF10, ZEB1, GLI3, TGFB1,
1.92592592 TGFB2, CHD7, PVRL1, MYC, APC, 1352 3.29598740 0.00100997 5.98E-0 GO:0007423~sensory organ development 26 3.31E-07 466 229 4.06E-06 6 BMP4, EGFR, RARG, TBX1, STAT3, 8 6 4 4
CDKN1B, DLX5, SIX1, FOXG1, VEGFA,
FOXC1
EGFR, CAV1, TNF, ERBB2, TGFB3,
GO:0043405~regulation of MAP kinase 1.48148148 KITLG, KIT, TP73, TGFB1, GH1, IRAK3, 1352 4.11773658 0.00106765 6.32E-0 20 3.50E-07 466 141 4.27E-06 activity 1 P2RX7, APOE, PTK2B, RIPK1, ILK, 8 4 1 4
CD81, IL1B, SYK, GHR
BMP4, CAV1, IL6, TNF, PTGS2, RXRA, GO:0051384~response to glucocorticoid 1.11111111 1352 5.58270056 0.00109983 6.51E-0 15 3.61E-07 PTGS1, IL1RN, IL10, FOS, CDKN1A, 466 78 4.38E-06 stimulus 1 8 1 8 4 EP300, IL1B, FAS, GHR
BMP4, BCL10, BMP2, SMAD4, PAX3, GO:0060562~epithelial tube 1.03703703 1352 6.06597911 0.00112341 6.65E-0 14 3.69E-07 GLI3, VASP, MAP3K7, CD44, SIX1, ILK, 466 67 4.46E-06 morphogenesis 7 8 7 3 4 TFAP2A, PBX1, TRAF6
ERBB2, SOX4, PRKDC, PAX3, SOX9,
GLI2, PTEN, GLI3, TGFB2, CHD7, ATG5, 1.85185185 1352 3.37558638 0.00115368 6.83E-0 GO:0007507~heart development 25 3.78E-07 HAND2, NFATC1, BMP4, BMP2, RXRA, 466 215 4.56E-06 2 8 6 2 4 TBX1, SMAD2, TAB1, SMO, NOTCH1,
EP300, MSX1, CRKL, FOXC1
GO:0050731~positive regulation of 0.88888888 CSF2, GH1, IL3, IL6, IL5, IFNG, CD81, 1352 7.41192585 0.00121882 7.21E-0 12 4.00E-07 466 47 4.80E-06 peptidyl-tyrosine phosphorylation 9 KITLG, TLR4, GHR, IL2, SYK 8 2 8 4
GO:0007178~transmembrane receptor 1.25925925 BMP4, IRAK1, NOG, BMP2, SMAD5, 1352 4.79136630 0.00128136 7.58E-0 17 4.20E-07 466 103 5.03E-06 protein serine/threonine kinase signaling 9 TGFB3, SMAD4, PML, SMAD3, SMAD2, 8 7 1 4 pathway SMAD1, TAB1, TGFB1, TGFB2,
MAP3K7, FOS, MSX1
GO:0050707~regulation of cytokine 0.74074074 P2RX7, CRTAM, TNF, PANX1, SAA1, 1352 9.67668097 0.00142047 8.41E-0 10 4.66E-07 466 30 5.55E-06 secretion 1 IFNG, PYCARD, FOXP3, IL10, IL1A 8 3 1 4
GO:0032649~regulation of 0.74074074 IL18, KLRK1, TLR3, RIPK2, RARA, 1352 9.67668097 0.00142047 8.41E-0 10 4.66E-07 466 30 5.55E-06 interferon-gamma production 1 FOXP3, TLR7, TLR8, TLR9, IFNAR1 8 3 1 4
IL7, SIPA1, TP53, SMAD4, PML, TP63,
GO:0030308~negative regulation of cell 1.18518518 SMAD3, RB1, ESR2, TP73, TGFB1, 1352 5.04870311 0.00154902 9.17E-0 16 5.08E-07 466 92 6.03E-06 growth 5 TGFB2, CDKN1A, CDKN2A, CDKN1B, 8 6 9 4
IP6K2
GO:0070302~regulation of TNF, CARD9, TLR3, TLR4, TP73, TGFB2, 1.03703703 1352 5.89015363 0.00160699 9.51E-0 stress-activated protein kinase signaling 14 5.27E-07 MAP3K7, NOD1, PTK2B, RIPK1, RIPK2, 466 69 6.23E-06 7 8 6 2 4 pathway IL1B, SYK, AXIN1
GO:0042475~odontogenesis of 0.81481481 BMP4, SMO, BMP2, JAG2, TP63, FOXC1, 1352 8.18796082 0.00165309 9.79E-0 11 5.42E-07 466 39 6.39E-06 dentine-containing tooth 5 TRAF6, EDA, GLI2, GLI3, CHUK 8 3 6 4
GO:0050715~positive regulation of 0.66666666 P2RX7, CRTAM, TNF, PANX1, SAA1, 1352 11.3595820 0.00173976 9 5.71E-07 466 23 6.70E-06 0.00103 cytokine secretion 7 IFNG, PYCARD, IL10, IL1A 8 1 3
BMP4, EGFR, BMP2, SIPA1, TP53, PML, GO:0045786~negative regulation of cell 1.11111111 1352 5.37593387 0.00105 15 5.85E-07 SMAD3, RB1, TGFB1, CDKN1A, 466 81 0.00178188 6.83E-06 cycle 1 8 4 5 CDKN2A, CDKN1B, FOXC1, NGFR, APC
RNF144B, UBE2A, LRSAM1, DZIP3,
UBE4A, CBL, CDC34, PARK2, UBOX5, GO:0070647~protein modification by 1.55555555 1352 3.81019313 0.00180486 0.00106 21 5.92E-07 UBE3C, UBE2B, UBE2N, FBXW7, 466 160 6.90E-06 small protein conjugation or removal 6 8 3 9 8 NEDD4, TRIM32, UBA3, FBXO4,
NEDD4L, TRAF6, TRIP12, RNF41
GO:0002478~antigen processing and 7 0.51851851 6.37E-07 TAP2, IFI30, TRAF6, HLA-DOA, 466 11 1352 18.4736636 0.00194181 7.39E-06 0.00115 presentation of exogenous peptide antigen 9 HLA-DMA, TAPBP, HLA-DRA 8 8 9
E2F1, THRA, TNF, PML, TP63, NFKB1,
PAWR, ZBTB16, PAX3, ZEB1, SOX9,
GLI2, GLI3, TGFB1, VDR, RUNX2, MYC,
GO:0010629~negative regulation of gene 3.03703703 TWIST2, CIITA, BMP4, EGR1, BMP2, 1352 2.36157095 0.00215316 0.00127 41 7.07E-07 466 504 8.16E-06 expression 7 RARG, RXRA, TP53, SMAD4, SMAD3, 8 2 4 5
SMAD2, RB1, SMAD1, FOXP3, STAT3,
CDKN1C, MSX1, CDKN1B, NEDD4,
IRF7, UBA3, IRF8, IRF2, ADAR
FGFR2, FGFR1, TNFRSF12A, SIPA1,
PML, TGFB3, TP63, SFN, IL7R, TGFB1,
GO:0032535~regulation of cellular 2.07407407 TGFB2, CDKN2A, PTK2B, PRSS2, ILK, 1352 2.99941402 0.00215513 0.00127 28 7.07E-07 466 271 8.14E-06 component size 4 IP6K2, RARG, IL7, SMAD4, TP53, 8 8 3 6
SMAD3, RB1, ESR2, TP73, CDKN1A,
CDKN1B, EP300, IL2
0.59259259 IRAK2, IRAK1, IRAK3, IL1R1, MYD88, 1352 13.6611966 0.00238094 GO:0070555~response to interleukin-1 8 7.82E-07 466 17 8.96E-06 0.00141 3 RELA, RIPK2, GHR 8 7 6
CIITA, CAV1, NOG, IL6, TNF, PTGS2,
GO:0051241~negative regulation of 1.55555555 NFKB1, FOXP3, SOX9, IL10, IRAK3, 1352 3.71726159 0.00268668 0.00159 21 8.82E-07 466 164 1.01E-05 multicellular organismal process 6 NOTCH1, P2RX7, APOE, VEGFA, IFNG, 8 3 3 1
RARA, LBP, NGFR, INPP5D, IL2
GO:0010718~positive regulation of 0.44444444 SMAD4, TGFB3, SMAD3, SMAD2, 1352 24.8828939 0.00283780 0.00168 6 9.32E-07 466 7 1.06E-05 epithelial to mesenchymal transition 4 TGFB1, TGFB2 8 3 6 1
GO:0045084~positive regulation of 0.44444444 1352 24.8828939 0.00283780 0.00168 6 9.32E-07 REL, RELA, IFNG, IRF1, TLR4, TRAF6 466 7 1.06E-05 interleukin-12 biosynthetic process 4 8 3 6 1
GO:0010770~positive regulation of cell 6 0.44444444 9.32E-07 SMAD4, TGFB3, SMAD3, SMAD2, 466 7 1352 24.8828939 0.00283780 1.06E-05 0.00168 morphogenesis involved in differentiation 4 TGFB1, TGFB2 8 3 6 1
RNASEL, TBK1, TGFB3, PRKG1, TGFB1,
TGFB2, MAP3K7, IFNG, ILK, IL1B,
CHUK, SYK, GHR, EGFR, IRAK2,
IRAK1, RIPK1, CD81, ROR2, RIPK2,
EIF2AK2, ERC1, MAP3K14, FGFR2, GO:0006468~protein amino acid 1352 2.13264183 0.00285735 0.00169 49 3.62962963 9.38E-07 FGFR1, TNF, STK11, CAMK2G, ERBB2, 466 667 1.06E-05 phosphorylation 8 4 9 2 PML, PRKDC, KIT, IRAK4, IGF1R,
IRAK3, MAP3K3, PTK2B, CAMK2D,
CAMK2B, CAMK2A, BMP2, HCK,
SMAD2, STAT1, IKBKE, P2RX7, PRLR,
JAK3, IKBKB
BMP4, CAV1, TNFRSF12A, FGF9, IL18,
FGF10, TBX1, TNFSF12, PTEN, TGFB2, GO:0048514~blood vessel 1.77777777 1352 3.30199540 0.00306598 0.00181 24 1.01E-06 MAP3K7, SMO, NOTCH1, CUL7, ATG5, 466 211 1.14E-05 morphogenesis 8 8 3 2 6 MEOX2, CTGF, APOE, HAND2, PTK2B,
VEGFA, ERAP1, IL1B, FOXC1
GO:0050851~antigen receptor-mediated 0.74074074 MAP3K7, UBE2N, BCL10, CD19, IKBKG, 1352 8.79698270 0.00348915 0.00206 10 1.15E-06 466 33 1.29E-05 signaling pathway 1 CD247, RIPK2, MALT1, TRAF6, SYK 8 3 7 7
FGFR1, FOXA2, ERBB2, JAG2, PAX6,
CDH1, PAX3, PRKG1, GLI2, GLI3, PTEN,
TGFB2, IGF1R, CD44, PVRL1, PTK2B, 2.74074074 1352 2.45230956 0.00355747 0.00210 GO:0030182~neuron differentiation 37 1.17E-06 ILK, APC, BMP4, EGFR, IL6, EGR2, 466 438 1.31E-05 1 8 2 8 8 RXRA, EFNB1, SMAD4, VASP, STAT3,
TP73, CDKN1C, SMO, NOTCH1, S100B,
NEDD4, DLX5, VEGFA, FOXG1, NGFR IRAK3, CBLB, TNF, NEDD4, APOE, GO:0042176~regulation of protein 0.88888888 1352 6.69924067 0.00361456 0.00214 12 1.19E-06 RELA, TRIM32, IFNG, IL1B, NEDD4L, 466 52 1.33E-05 catabolic process 9 8 3 8 2 IL10, APC
BMP4, BMP2, FOXA2, SMAD4, FGF10, GO:0001763~morphogenesis of a 1.03703703 1352 5.49217028 0.00371643 0.00220 14 1.22E-06 GLI2, GLI3, TGFB1, NOTCH1, CD44, 466 74 1.36E-05 branching structure 7 8 2 1 2 ILK, SIX1, VEGFA, PBX1
BMP4, WNT5A, BMP2, NOG, THRA, 1.03703703 1352 5.49217028 0.00371643 0.00220 GO:0051216~cartilage development 14 1.22E-06 FGF9, ZEB1, SOX9, MSX1, CTGF, ROR2, 466 74 1.36E-05 7 8 2 1 2 COL1A1, RUNX2, GHR
E2F1, CAV1, THRA, TNF, PML, TGFB3,
TP63, NFKB1, PAWR, ZBTB16, PAX3,
ZEB1, SOX9, GLI2, GLI3, TGFB1, IL10,
VDR, APOE, INPP5D, RUNX2, TWIST2, GO:0009890~negative regulation of 3.25925925 1352 2.22918305 0.00372493 0.00220 44 1.22E-06 CIITA, EGR1, BMP2, IL6, RARG, RXRA, 466 573 1.36E-05 biosynthetic process 9 8 1 9 7 TP53, SMAD4, SMAD3, SMAD2, RB1,
FOXP3, STAT3, CDKN1C, MSX1,
CDKN1B, NEDD4, IRF7, IRF8, UBA3,
ASB1, IRF2
CAV1, TNF, TP53, PML, SMAD3, CDH1,
GO:0052547~regulation of peptidase 1.11111111 SFN, STAT1, NLRP1, CDKN2A, 1352 5.06337957 0.00378643 0.00224 15 1.24E-06 466 86 1.37E-05 activity 1 TNFRSF10B, NOD1, PYCARD, MYC, 8 9 2 4
IFI6
IL7, SIPA1, TP53, SMAD4, PML, TP63,
GO:0045792~negative regulation of cell 1.18518518 SMAD3, RB1, ESR2, TP73, TGFB1, 1352 4.69172410 0.00407816 0.00241 16 1.34E-06 466 99 1.48E-05 size 5 TGFB2, CDKN1A, CDKN2A, CDKN1B, 8 8 4 7
IP6K2 BMP4, IL6, IL2RA, IL7, SMAD5,
GO:0048872~homeostasis of number of 1.18518518 STAT5B, RB1, FOXP3, IL7R, TGFB1, 1352 4.64480686 0.00464771 0.00275 16 1.53E-06 466 100 1.68E-05 cells 5 P2RX7, VEGFA, IKBKG, IFNG, FAS, 8 7 6 5
IKBKB
CAV1, SOCS3, IL18, CREBBP, STAT5B,
1.40740740 JAG2, TGFB3, SMAD4, PML, SMAD3, 1352 3.91184975 0.00484393 0.00287 GO:0070482~response to oxygen levels 19 1.59E-06 466 141 1.74E-05 7 UBE2B, TGFB1, TGFB2, CDKN1A, 8 5 1 2
EP300, PTK2B, VEGFA, RYR1, CAMK2D
GO:0046427~positive regulation of 0.66666666 CSF2, GH1, IL3, IL6, IL5, IFNG, PRL, 1352 10.0488610 0.00505269 0.00299 9 1.66E-06 466 26 1.81E-05 JAK-STAT cascade 7 GHR, IL2 8 1 3 6
E2F1, CAV1, THRA, TNF, PML, TGFB3,
TP63, NFKB1, PAWR, ZBTB16, PAX3,
ZEB1, SOX9, GLI2, GLI3, TGFB1, IL10,
GO:0031327~negative regulation of 3.18518518 VDR, INPP5D, RUNX2, TWIST2, CIITA, 1352 2.22511915 0.00526077 43 1.73E-06 466 561 1.88E-05 0.00312 cellular biosynthetic process 5 EGR1, BMP2, IL6, RARG, RXRA, TP53, 8 4 6
SMAD4, SMAD3, SMAD2, RB1, FOXP3,
STAT3, CDKN1C, MSX1, CDKN1B,
NEDD4, IRF7, IRF8, UBA3, ASB1, IRF2
BMP4, BMP2, FOXA2, SMAD4, FGF10, GO:0048754~branching morphogenesis 0.96296296 1352 5.80600858 0.00552082 0.00327 13 1.82E-06 GLI2, GLI3, NOTCH1, CD44, SIX1, 466 65 1.96E-05 of a tube 3 8 4 1 4 VEGFA, ILK, PBX1
TNF, CARD9, TLR3, TLR4, TP73, 0.96296296 1352 5.80600858 0.00552082 0.00327 GO:0046328~regulation of JNK cascade 13 1.82E-06 MAP3K7, NOD1, PTK2B, RIPK1, RIPK2, 466 65 1.96E-05 3 8 4 1 4 IL1B, SYK, AXIN1
GO:0045076~regulation of interleukin-2 0.59259259 CARD11, CARD9, STAT5B, IL1B, IRF4, 1352 12.2231759 0.00580021 0.00344 8 1.91E-06 466 19 2.06E-05 biosynthetic process 3 FOXP3, IL1A, CD28 8 7 3 1 GO:0045621~positive regulation of 0.74074074 IL2RA, IL7, STAT5B, RARA, IL2RG, 1352 8.29429797 0.00600079 10 1.97E-06 466 35 2.12E-05 0.00356 lymphocyte differentiation 1 INPP5D, IL7R, HLA-DMA, IL2, SYK 8 7 9
0.74074074 BMP4, NOG, BMP2, CD44, ILK, SIX1, 1352 8.29429797 0.00600079 GO:0001657~ureteric bud development 10 1.97E-06 466 35 2.12E-05 0.00356 1 SMAD4, PBX1, FOXC1, GLI3 8 7 9
EGFR, TNF, ERBB2, TGFB3, KITLG, GO:0043406~positive regulation of MAP 1.18518518 1352 4.55373222 0.00600464 0.00356 16 1.97E-06 KIT, TGFB1, GH1, P2RX7, PTK2B, 466 102 2.11E-05 kinase activity 5 8 3 8 2 RIPK1, ILK, CD81, IL1B, SYK, GHR
GO:0032648~regulation of 0.51851851 MAVS, DDX58, TICAM1, TLR3, TLR7, 1352 15.6315615 0.00678365 0.00402 7 2.23E-06 466 13 2.38E-05 interferon-beta production 9 TLR8, TLR9 8 7 2 6
CAV1, NOG, SOCS3, FGF9, RELA,
SOCS1, TGFB3, NFKBIA, PAWR, IRS1, GO:0009968~negative regulation of 1.77777777 1352 3.15258384 0.00685762 24 2.26E-06 PTEN, CISH, IRAK3, CBLB, P2RX7, 466 221 2.40E-05 0.00407 signal transduction 8 8 6 9 LRP6, IL1B, INPP5D, PTPN1, NGFR,
TNFAIP3, RUNX2, AXIN1, APC
E2F1, THRA, TNF, PML, TGFB3, TP63,
NFKB1, PAWR, ZBTB16, PAX3, ZEB1,
SOX9, GLI2, GLI3, TGFB1, IL10, VDR,
GO:0010558~negative regulation of 3.11111111 INPP5D, RUNX2, TWIST2, CIITA, EGR1, 1352 2.22899781 0.00687297 0.00407 42 2.26E-06 466 547 2.39E-05 macromolecule biosynthetic process 1 BMP2, IL6, RARG, RXRA, TP53, SMAD4, 8 1 3 9
SMAD3, SMAD2, RB1, FOXP3, STAT3,
CDKN1C, MSX1, CDKN1B, NEDD4,
IRF7, IRF8, UBA3, ASB1, IRF2
GO:0002281~macrophage activation 0.44444444 1352 21.7725321 0.00733671 0.00435 6 2.41E-06 TICAM1, TLR2, TLR3, TLR4, LBP, TLR7 466 8 2.55E-05 during immune response 4 8 9 3 5
GO:0045075~regulation of interleukin-12 0.44444444 1352 21.7725321 0.00733671 0.00435 6 2.41E-06 REL, RELA, IFNG, IRF1, TLR4, TRAF6 466 8 2.55E-05 biosynthetic process 4 8 9 3 5 0.74074074 P2RX7, IL6, IL2RA, IFNG, IKBKG, 1352 8.06390081 0.00775304 0.00460 GO:0001776~leukocyte homeostasis 10 2.55E-06 466 36 2.68E-05 1 STAT5B, FAS, IKBKB, FOXP3, TGFB1 8 1 6 3
EGFR, CUL3, CDKN1A, CDKN1B,
GO:0000082~G1/S transition of mitotic 0.88888888 CDKN2A, CAMK2G, CAMK2D, 1352 6.22072348 0.00785338 0.00466 12 2.59E-06 466 56 2.71E-05 cell cycle 9 CAMK2B, CDC34, RB1, CAMK2A, 8 3 4 3
NFATC1
TXNIP, BMP4, FOS, CAV1, P2RX7, GO:0009612~response to mechanical 0.88888888 1352 6.22072348 0.00785338 0.00466 12 2.59E-06 BMP2, TNF, PTK2B, RELA, COL1A1, 466 56 2.71E-05 stimulus 9 8 3 4 3 STAT1, MYC
UBE2N, IGF1R, CSF2, IL3, IFNG, TGFB3, GO:0051054~positive regulation of DNA 0.88888888 1352 6.22072348 0.00785338 0.00466 12 2.59E-06 KITLG, TNFSF12, CD40, GLI2, TGFB1, 466 56 2.71E-05 metabolic process 9 8 3 4 3 IL2
TNF, TP53, PML, SMAD3, CDH1, SFN, GO:0043281~regulation of caspase 1.03703703 1352 5.14456456 0.00799692 0.00474 14 2.63E-06 STAT1, NLRP1, CDKN2A, TNFRSF10B, 466 79 2.75E-05 activity 7 8 8 9 9 NOD1, PYCARD, MYC, IFI6
FGFR1, ERBB2, PAX6, CDH1, GLI2,
PRKG1, PTEN, IGF1R, PVRL1, CD44, GO:0031175~neuron projection 1.92592592 1352 2.94836373 0.00800778 0.00475 26 2.64E-06 PTK2B, ILK, APC, EGFR, IL6, EGR2, 466 256 2.74E-05 development 6 8 4 9 5 RXRA, EFNB1, VASP, SMO, NOTCH1,
S100B, NEDD4, DLX5, FOXG1, NGFR
THRA, STAT5B, TGFB3, IL10, TGFB1,
CBFB, CDKN2A, GATA3, IFNG, RARA,
GO:0006355~regulation of transcription, 7.18518518 TWIST2, PITX2, CIITA, BCL10, RARG, 1352 1.58822005 0.00842387 0.00500 97 2.77E-06 466 1773 2.88E-05 DNA-dependent 5 RELA, RXRA, RELB, EP300, MSX1, 8 8 7 3
SIX1, VEGFA, FOXG1, TFAP2A, PIAS1,
ERC1, LITAF, NFKBIA, SOX4, SOX9, VDR, RUNX2, BMP4, BMP2, MLL,
SMAD5, CREBBP, SMAD4, SMAD3,
SMAD2, SMAD1, FOXP3, CDKN1C,
NOTCH1, CDKN1B, NEDD4, DLX5,
E2F1, FOXA2, PAX6, TP63, NFKB1,
NFKB2, PAWR, PAX3, ZEB1, GLI2, FOS,
PAX9, MYC, EGR1, EGR2, SOX11, TP53,
ESR2, RB1, IFNAR2, FOXC1, TNF,
PRKDC, ZBTB16, HIC1, TNFRSF1A,
REL, NR1D1, HAND2, NFATC1, IL6, IL5,
TBX1, STAT1, TP73, STAT3, STAT2,
IRF9, MEOX2, IRF5, IRF6, IRF7, IRF8,
IRF1, IRF2, IRF3, PBX1, IRF4, JAK3, IL2
BMP4, NOG, BMP2, FOXA2,
TNFRSF12A, RELA, TP53, PAX6, KIT, GO:0051960~regulation of nervous 1352 3.32635908 0.00509 22 1.62962963 2.82E-06 SMAD1, GLI2, TGFB1, SMO, NOTCH1, 466 192 0.00857213 2.92E-05 system development 8 4 2 PVRL1, APOE, ILK, SIX1, IFNG, FOXG1,
PBX1, NGFR
BMP4, TXNIP, CAV1, PTGS2, SOCS3, GO:0043627~response to estrogen 1.18518518 1352 4.42362558 0.00870589 0.00517 16 2.87E-06 STAT5B, SOCS1, TGFB3, PTEN, STAT3, 466 105 2.95E-05 stimulus 5 8 8 6 2 TGFB1, GH1, GATA3, IL1B, RARA, GHR
0.66666666 PVR, P2RX7, CRTAM, TAP2, IFNG, 1352 9.33108522 0.00944004 GO:0031341~regulation of cell killing 9 3.11E-06 466 28 3.19E-05 0.00561 7 STAT5B, KLRK1, IL7R, CD226 8 4 4
TAP2, IFI30, ERAP1, ERAP2, TRAF6, GO:0048002~antigen processing and 0.66666666 1352 9.33108522 0.00944004 9 3.11E-06 HLA-DOA, HLA-DMA, TAPBP, 466 28 3.19E-05 0.00561 presentation of peptide antigen 7 8 4 4 HLA-DRA BCL10, CRTAM, IL6, CARD9, CD8A,
1.33333333 RELA, PRKDC, IL7R, HLA-DMA, TLR7, 1352 3.89955800 0.01025237 0.00609 GO:0002252~immune effector process 18 3.38E-06 466 134 3.46E-05 3 TLR8, MYD88, CD40LG, TICAM1, 8 4 1 5
INPP5D, LBP, FAS, HLA-DRA
CAV1, SOCS3, IL18, CREBBP, STAT5B,
1.33333333 JAG2, TGFB3, SMAD4, PML, SMAD3, 1352 3.89955800 0.01025237 0.00609 GO:0001666~response to hypoxia 18 3.38E-06 466 134 3.46E-05 3 UBE2B, TGFB1, TGFB2, EP300, PTK2B, 8 4 1 5
VEGFA, RYR1, CAMK2D
E2F1, THRA, TNF, PML, TP63, NFKB1,
PAWR, PAX3, ZBTB16, ZEB1, SOX9,
GLI2, GLI3, TGFB1, VDR, RUNX2,
GO:0016481~negative regulation of 2.74074074 TWIST2, CIITA, EGR1, BMP2, RARG, 1352 2.34011239 0.01048958 0.00623 37 3.46E-06 466 459 3.53E-05 transcription 1 RXRA, SMAD4, TP53, SMAD3, SMAD2, 8 2 6 7
RB1, FOXP3, STAT3, CDKN1C, MSX1,
CDKN1B, NEDD4, IRF7, UBA3, IRF8,
IRF2
E2F1, CAV1, THRA, TNF, PML, TGFB3,
TP63, NFKB1, PAWR, ZBTB16, PAX3,
ZEB1, SOX9, GLI2, GLI3, TGFB1, IL10,
GO:0051172~negative regulation of 2.96296296 VDR, RUNX2, TWIST2, CIITA, EGR1, 1352 2.23738288 0.01146419 40 3.78E-06 466 519 3.84E-05 0.00682 nitrogen compound metabolic process 3 BMP2, RARG, RXRA, TP53, SMAD4, 8 4 8
SMAD3, SMAD2, RB1, FOXP3, STAT3,
CDKN1C, MSX1, CDKN1B, NEDD4,
IRF7, UBA3, IRF8, IRF2
GO:0019884~antigen processing and 0.51851851 TAP2, IFI30, TRAF6, HLA-DOA, 1352 14.5150214 0.01150001 0.00684 7 3.79E-06 466 14 3.84E-05 presentation of exogenous antigen 9 HLA-DMA, TAPBP, HLA-DRA 8 6 7 1 GO:0032330~regulation of chondrocyte 0.51851851 PTHLH, BMP4, RELA, SOX9, GLI2, 1352 14.5150214 0.01150001 0.00684 7 3.79E-06 466 14 3.84E-05 differentiation 9 RUNX2, GLI3 8 6 7 1
BMP4, PTGS2, SOCS3, RXRA, RELA,
GO:0014070~response to organic cyclic 1.25925925 STAT1, PTEN, TGFB1, STAT3, FOS, 1352 4.07860107 0.01150381 0.00684 17 3.79E-06 466 121 3.83E-05 substance 9 CDKN1A, P2RX7, CD44, PTK2B, RYR1, 8 1 8 3
IL1B, GHR
NOG, PTGS2, FGF9, STAT5B, TGFB3,
JAG2, PRKDC, TP63, KIT, ZBTB16,
GO:0003006~reproductive developmental 1.92592592 SOX9, TGFB2, VDR, IGF1R, CHD7, 1352 2.88084395 0.01212171 0.00721 26 4.00E-06 466 262 4.02E-05 process 6 PTK2B, OCA2, AXIN1, BMP4, SMAD5, 8 4 7 3
UBE2B, VEGFA, ASB1, ROR2, FOXC1,
PBX1
THRA, STAT5B, TGFB3, TGFB1, IL10,
CBFB, CDKN2A, GATA3, IFNG, RARA,
TWIST2, PITX2, CIITA, BCL10, RARG,
RELA, RXRA, RELB, EP300, MSX1,
SIX1, VEGFA, FOXG1, TFAP2A, PIAS1,
ERC1, LITAF, NFKBIA, SOX4, SOX9,
GO:0051252~regulation of RNA 7.25925925 VDR, RUNX2, BMP4, BMP2, MLL, 1352 1.56919150 0.01221882 0.00727 98 4.03E-06 466 1813 4.04E-05 metabolic process 9 SMAD5, CREBBP, SMAD4, SMAD3, 8 9 3 1
SMAD2, SMAD1, FOXP3, CDKN1C,
NOTCH1, CDKN1B, NEDD4, DLX5,
E2F1, FOXA2, PAX6, TP63, NFKB1,
PAWR, NFKB2, PAX3, ZEB1, GLI2, FOS,
PAX9, MYC, EGR1, EGR2, SOX11, TP53,
RB1, ESR2, IFNAR2, FOXC1, TNF, PRKDC, ZBTB16, HIC1, TNFRSF1A,
TNFRSF1B, REL, NR1D1, HAND2,
NFATC1, IL6, IL5, TBX1, STAT1, TP73,
STAT3, STAT2, IRF9, MEOX2, IRF5,
IRF6, IRF7, IRF8, IRF1, IRF2, IRF3,
PBX1, IRF4, JAK3, IL2
TNF, TP53, PML, SMAD3, CDH1, SFN, GO:0052548~regulation of endopeptidase 1.03703703 1352 4.95634879 0.00730 14 4.05E-06 STAT1, NLRP1, CDKN2A, TNFRSF10B, 466 82 0.01227931 4.05E-05 activity 7 8 1 8 NOD1, PYCARD, MYC, IFI6
IL5, TNF, STAT5B, KITLG, TLR3, GO:0045637~regulation of myeloid cell 0.96296296 1352 5.39129368 0.01243459 0.00740 13 4.10E-06 NFKBIA, TLR4, ZBTB16, RB1, TNFSF11, 466 70 4.09E-05 differentiation 3 8 5 8 1 INPP5D, FAS, APC
BMP4, WNT5A, FOXA2, FGF9, TGFB3,
GO:0060541~respiratory system 1.18518518 FGF10, SMAD2, GLI2, TAB1, GLI3, 1352 4.30074709 0.01243889 0.00740 16 4.10E-06 466 108 4.08E-05 development 5 PTHLH, NOTCH1, EP300, CHD7, CTGF, 8 9 9 3
VEGFA
BMP4, NOG, BMP2, FOXA2,
1.48148148 TNFRSF12A, RELA, TP53, PAX6, KIT, 1352 3.49759553 0.01301872 GO:0050767~regulation of neurogenesis 20 4.30E-06 466 166 4.25E-05 0.00775 1 SMAD1, GLI2, TGFB1, SMO, NOTCH1, 8 2 4
APOE, ILK, SIX1, FOXG1, PBX1, NGFR
CAV1, NOG, THRA, NFKBIA, NFKB1,
SFN, TGFB2, IRAK3, EDNRB, CDKN2A,
GO:0044092~negative regulation of 2.22222222 APOE, ILK, IL1B, NQO1, APC, IRAK2, 1352 2.60748888 0.01371574 0.00816 30 4.53E-06 466 334 4.47E-05 molecular function 2 IRAK1, IL7, TP53, RB1, FOXP3, TP73, 8 5 5 8
CDKN1C, PTHLH, SMO, CDKN1A,
CDKN1B, CCR2, PBX1, IFI6 TNF, ERBB2, IL18, SIPA1, STAT5B,
1.33333333 JAG2, SMAD3, PTEN, TGFB1, TGFB2, 1352 3.81416622 0.01389380 0.00827 GO:0030155~regulation of cell adhesion 18 4.59E-06 466 137 4.51E-05 3 CDKN2A, PRLR, SAA1, PRSS2, ILK, 8 3 8 5
IL1B, COL1A1, APC
EGFR, TNF, STAT5B, TP53, PML,
GO:0007346~regulation of mitotic cell 1.40740740 SMAD3, RB1, TGFB1, CDKN2A, CUL7, 1352 3.62875536 0.01432664 0.00853 19 4.73E-06 466 152 4.64E-05 cycle 7 FOXG1, CAMK2D, IL1B, HECTD3, 8 5 1 5
FOXC1, MYC, IL1A, APC, CD28
BMP4, BMP2, NOG, SOX11, SMAD4, 1.11111111 1352 4.53594420 0.01450587 0.00864 GO:0001822~kidney development 15 4.79E-06 SMAD1, ZBTB16, GLI2, GLI3, CD44, 466 96 4.68E-05 1 8 6 7 2 ILK, SIX1, FOXC1, PBX1, APC
CAV1, NOG, PTGS2, FGF9, TGFB3,
NFKBIA, PAWR, PTEN, IRAK3, IL1B, GO:0010648~negative regulation of cell 1.85185185 1352 2.92641561 0.01480682 0.00882 25 4.89E-06 INPP5D, RUNX2, APC, AXIN1, SOCS3, 466 248 4.77E-05 communication 2 8 7 4 3 RELA, SOCS1, IRS1, CISH, P2RX7,
CBLB, LRP6, PTPN1, NGFR, TNFAIP3
TXNIP, PTGS2, FOXA2, RELA, PAX6,
FGF10, TP63, SFN, GLI2, SOX9, TGFB2, 1352 3.20935147 0.01512160 0.00901 GO:0007398~ectoderm development 22 1.62962963 5.00E-06 PTHLH, NOTCH1, CDKN2A, IRF6, 466 199 4.85E-05 8 8 2 2 CTGF, TFAP2A, MADCAM1, COL1A1,
NGFR, EDA, APC
BMP4, BMP2, NOG, SOX11, SMAD4, GO:0001655~urogenital system 1.18518518 1352 4.22255169 0.01565694 0.00933 16 5.17E-06 TP63, SMAD1, ZBTB16, GLI2, GLI3, 466 110 5.01E-05 development 5 8 7 5 3 CD44, ILK, SIX1, PBX1, FOXC1, APC
GO:0045926~negative regulation of 1.18518518 IL7, SIPA1, TP53, SMAD4, PML, TP63, 1352 4.22255169 0.01565694 0.00933 16 5.17E-06 466 110 5.01E-05 growth 5 SMAD3, RB1, ESR2, TP73, TGFB1, 8 7 5 3 TGFB2, CDKN1A, CDKN2A, CDKN1B,
IP6K2
SOCS3, RXRA, RELA, PTGS1, TP53,
1.18518518 TGFB3, PML, TP63, PTEN, AGER, 1352 4.22255169 0.01565694 0.00933 GO:0007568~aging 16 5.17E-06 466 110 5.01E-05 5 TGFB1, FOS, CDKN2A, ILK, IL1B, 8 7 5 3
INPP5D
MAP3K7, FOS, SMAD5, PML, SMAD4, GO:0007179~transforming growth factor 0.88888888 1352 5.80600858 0.01590148 12 5.26E-06 TGFB3, SMAD3, SMAD2, SMAD1, TAB1, 466 60 5.07E-05 0.00948 beta receptor signaling pathway 9 8 4 8 TGFB1, TGFB2
GO:0051023~regulation of 0.44444444 1352 19.3533619 0.00952 6 5.28E-06 IL6, TNF, CD40LG, CD40, TRAF6, IL2 466 9 0.015971 5.08E-05 immunoglobulin secretion 4 8 5 2
GO:0010717~regulation of epithelial to 0.44444444 SMAD4, TGFB3, SMAD3, SMAD2, 1352 19.3533619 0.00952 6 5.28E-06 466 9 0.015971 5.08E-05 mesenchymal transition 4 TGFB1, TGFB2 8 5 2
GO:0032874~positive regulation of 0.44444444 NOD1, CARD9, IL1B, RIPK2, TLR4, 1352 19.3533619 0.00952 6 5.28E-06 466 9 0.015971 5.08E-05 stress-activated MAPK cascade 4 TGFB2 8 5 2
GO:0002824~positive regulation of
adaptive immune response based on 0.66666666 MAP3K7, PVR, TRAF2, P2RX7, TAP2, 1352 8.70901287 0.01667074 0.00994 somatic recombination of immune 9 5.51E-06 466 30 5.29E-05 7 IL1B, MALT1, TRAF6, CD226 8 6 4 3 receptors built from immunoglobulin
superfamily domains
E2F1, TNF, TP63, NFKB1, PAX3,
ZBTB16, ZEB1, PAWR, SOX9, GLI2,
GO:0045892~negative regulation of 2.29629629 VDR, TWIST2, CIITA, EGR1, BMP2, 1352 2.52789699 0.01708598 0.01019 31 5.65E-06 466 356 5.40E-05 transcription, DNA-dependent 6 RARG, RXRA, SMAD4, TP53, SMAD3, 8 6 3 3
SMAD2, RB1, FOXP3, STAT3, CDKN1C,
MSX1, CDKN1B, NEDD4, IRF7, IRF8, IRF2
GO:0001658~branching involved in 0.59259259 BMP4, BMP2, CD44, ILK, SIX1, SMAD4, 1352 10.5563792 0.01064 8 5.90E-06 466 22 0.01783773 5.62E-05 ureteric bud morphogenesis 3 PBX1, GLI3 8 4 5
GO:0046824~positive regulation of 0.59259259 SMO, TNF, NEDD4, SMAD3, IL1B, 1352 10.5563792 0.01064 8 5.90E-06 466 22 0.01783773 5.62E-05 nucleocytoplasmic transport 3 CDH1, EDA, GLI3 8 4 5
0.59259259 BMP4, BMP2, CD44, ILK, SIX1, SMAD4, 1352 10.5563792 0.01064 GO:0060675~ureteric bud morphogenesis 8 5.90E-06 466 22 0.01783773 5.62E-05 3 PBX1, GLI3 8 4 5
FGFR1, ERBB2, PAX6, CDH1, PRKG1,
GLI2, PTEN, TGFB2, IGF1R, CD44,
2.22222222 PVRL1, PTK2B, ILK, APC, EGFR, IL6, 1352 2.56903034 0.01092 GO:0048666~neuron development 30 6.06E-06 466 339 0.01830949 5.76E-05 2 EGR2, RXRA, EFNB1, TP73, VASP, 8 7 9
CDKN1C, SMO, NOTCH1, S100B,
NEDD4, DLX5, VEGFA, FOXG1, NGFR
EGFR, IRS2, IL6, SMAD3, FGF10, KIT, GO:0040017~positive regulation of 1.11111111 1352 4.44337391 0.01853712 0.01106 15 6.13E-06 AGER, IRS1, TGFB1, TGFB2, IGF1R, 466 98 5.81E-05 locomotion 1 8 6 4 6 PTK2B, VEGFA, ILK, APC
GO:0032642~regulation of chemokine 0.51851851 IL6, TNF, TICAM1, IFNG, TLR3, IL1B, 1352 13.5473533 0.01854533 0.01107 7 6.14E-06 466 15 5.80E-05 production 9 RIPK2 8 6 3 1
0.51851851 TICAM1, TLR1, TLR2, TLR3, TLR4, LBP, 1352 13.5473533 0.01854533 0.01107 GO:0042116~macrophage activation 7 6.14E-06 466 15 5.80E-05 9 TLR7 8 6 3 1
GO:0045359~positive regulation of 1352 29.0300429 0.02024335 0.01209 5 0.37037037 6.71E-06 TICAM1, TLR3, TLR7, TLR8, TLR9 466 5 6.31E-05 interferon-beta biosynthetic process 8 2 2 5
GO:0045354~regulation of 1352 29.0300429 0.02024335 0.01209 5 0.37037037 6.71E-06 TLR3, TLR7, TLR8, IL10, TLR9 466 5 6.31E-05 interferon-alpha biosynthetic process 8 2 2 5
GO:0045357~regulation of 1352 29.0300429 0.02024335 0.01209 5 0.37037037 6.71E-06 TICAM1, TLR3, TLR7, TLR8, TLR9 466 5 6.31E-05 interferon-beta biosynthetic process 8 2 2 5 BMP4, WNT5A, FOXA2, FGF9, TGFB3, 1.11111111 1352 4.39849135 0.02089838 0.01249 GO:0030324~lung development 15 6.92E-06 FGF10, SMAD2, GLI2, TAB1, GLI3, 466 99 6.50E-05 1 8 1 9 1 PTHLH, NOTCH1, EP300, CTGF, VEGFA
GO:0042509~regulation of tyrosine 0.66666666 CSF2, GH1, IL3, CAV1, IL6, SOCS1, 1352 8.42807697 0.01300 9 7.21E-06 466 31 0.02174315 6.74E-05 phosphorylation of STAT protein 7 IFNG, GHR, IL2 8 6 1
GO:0002821~positive regulation of 0.66666666 MAP3K7, PVR, TRAF2, P2RX7, TAP2, 1352 8.42807697 0.01300 9 7.21E-06 466 31 0.02174315 6.74E-05 adaptive immune response 7 IL1B, MALT1, TRAF6, CD226 8 6 1
E2F1, TNF, TP63, NFKB1, PAX3,
ZBTB16, ZEB1, PAWR, SOX9, GLI2,
VDR, TWIST2, CIITA, EGR1, BMP2, GO:0051253~negative regulation of RNA 2.29629629 1352 0.02369916 0.01418 31 7.86E-06 RARG, RXRA, SMAD4, TP53, SMAD3, 466 362 2.48599815 7.33E-05 metabolic process 6 8 2 5 SMAD2, RB1, FOXP3, STAT3, CDKN1C,
MSX1, CDKN1B, NEDD4, IRF7, IRF8,
IRF2
IL6, IL5, TNF, TP53, TGFB3, NFKBIA, GO:0043193~positive regulation of 1.03703703 1352 4.67150115 0.02394683 0.01433 14 7.95E-06 PRKDC, SMAD3, SMAD2, ESR2, FOXP3, 466 87 7.39E-05 gene-specific transcription 7 8 9 6 5 IL10, NOTCH1, IRF4
CSF2, IL3, TP53, TGFB3, KITLG, GO:0051052~regulation of DNA 1.18518518 1352 4.07439198 0.02436419 0.01458 16 8.09E-06 TNFSF12, CD40, IL7R, GLI2, TGFB1, 466 114 7.50E-05 metabolic process 5 8 9 6 8 IL10, UBE2N, IGF1R, IFNG, MYC, IL2
EGFR, IRAK1, TRAF2, TLR3, MALT1,
GO:0032147~activation of protein kinase 1.18518518 TAB1, CISH, TGFB2, MAP3K7, 1352 4.07439198 0.02436419 0.01458 16 8.09E-06 466 114 7.50E-05 activity 5 TNFRSF10B, PRLR, PTK2B, IKBKG, 8 9 6 8
TRAF6, GHR, IL2
GO:0050852~T cell receptor signaling 0.59259259 MAP3K7, UBE2N, BCL10, IKBKG, 1352 10.0974062 0.02479873 0.01485 8 8.23E-06 466 23 7.61E-05 pathway 3 CD247, RIPK2, MALT1, TRAF6 8 3 8 2 GO:0045582~positive regulation of T cell 0.66666666 IL2RA, IL7, STAT5B, RARA, IL2RG, 1352 8.16469957 0.02803649 0.01681 9 9.32E-06 466 32 8.59E-05 differentiation 7 IL7R, HLA-DMA, IL2, SYK 8 1 3 8
0.51851851 EGFR, CAV1, ERBB2, PAX6, TGFB3, 1352 12.7006437 0.02866536 0.01720 GO:0022612~gland morphogenesis 7 9.54E-06 466 16 8.76E-05 9 TGFB1, TGFB2 8 8 6 1
BMP4, WNT5A, FOXA2, FGF9, TGFB3, GO:0030323~respiratory tube 1.11111111 1352 4.26912395 0.02963021 0.01778 15 9.86E-06 FGF10, SMAD2, GLI2, TAB1, GLI3, 466 102 9.03E-05 development 1 8 9 2 9 PTHLH, NOTCH1, EP300, CTGF, VEGFA
0.74074074 BMP4, NOTCH1, FOXA2, JAG2, PAX6, 1352 6.91191498 0.03021928 0.01814 GO:0048663~neuron fate commitment 10 1.01E-05 466 42 9.19E-05 1 SMAD4, PAX3, GLI2, GLI3, TGFB2 8 1 1 8
GO:0045073~regulation of chemokine 0.44444444 1352 17.4180257 0.03080551 0.01850 6 1.03E-05 IL6, TNF, TICAM1, IFNG, TLR3, IL1B 466 10 9.34E-05 biosynthetic process 4 8 5 6 5
GO:0032872~regulation of 0.44444444 NOD1, CARD9, IL1B, RIPK2, TLR4, 1352 17.4180257 0.03080551 0.01850 6 1.03E-05 466 10 9.34E-05 stress-activated MAPK cascade 4 TGFB2 8 5 6 5
WNT5A, NOG, RARG, FGF9, TP63, 1.11111111 1352 4.22767615 0.03317226 0.01995 GO:0048736~appendage development 15 1.11E-05 FGF10, ZBTB16, GLI3, NOTCH1, CHD7, 466 103 1.00E-04 1 8 3 5 1 MSX1, MEOX2, DLX5, LRP6, PBX1
WNT5A, NOG, RARG, FGF9, TP63, 1.11111111 1352 4.22767615 0.03317226 0.01995 GO:0060173~limb development 15 1.11E-05 FGF10, ZBTB16, GLI3, NOTCH1, CHD7, 466 103 1.00E-04 1 8 3 5 1 MSX1, MEOX2, DLX5, LRP6, PBX1
TNF, CARD9, TLR3, TLR4, TP73, TGFB2, GO:0080135~regulation of cellular 1.11111111 1352 4.22767615 0.03317226 0.01995 15 1.11E-05 UBE2N, MAP3K7, NOD1, PTK2B, RIPK1, 466 103 1.00E-04 response to stress 1 8 3 5 1 RIPK2, IL1B, SYK, AXIN1
GO:0031343~positive regulation of cell 0.59259259 PVR, P2RX7, CRTAM, TAP2, IFNG, 1352 9.67668097 0.03382287 0.02034 8 1.13E-05 466 24 1.02E-04 killing 3 STAT5B, KLRK1, CD226 8 3 5 9
GO:0045778~positive regulation of 0.59259259 BMP4, P2RX7, BMP2, TGFB3, SMAD3, 1352 9.67668097 0.03382287 0.02034 8 1.13E-05 466 24 1.02E-04 ossification 3 RUNX2, TGFB1, TGFB2 8 3 5 9 GO:0014033~neural crest cell 0.66666666 SMO, EDNRB, HAND2, EFNB1, KITLG, 1352 7.91728443 0.03576325 0.02153 9 1.19E-05 466 33 1.08E-04 differentiation 7 TBX1, FOXC1, PAX3, SOX9 8 2 3 8
GO:0014032~neural crest cell 0.66666666 SMO, EDNRB, HAND2, EFNB1, KITLG, 1352 7.91728443 0.03576325 0.02153 9 1.19E-05 466 33 1.08E-04 development 7 TBX1, FOXC1, PAX3, SOX9 8 2 3 8
GO:0045667~regulation of osteoblast 0.74074074 BMP4, IL6, BMP2, DLX5, SMAD5, 1352 6.75117277 0.03694094 0.02226 10 1.23E-05 466 43 1.11E-04 differentiation 1 SMAD3, SMAD1, RUNX2, TWIST2, APC 8 2 1 1
CDKN2A, NOD1, TNF, TNFRSF10B, GO:0006919~activation of caspase 0.81481481 1352 5.91352726 0.03846061 0.02319 11 1.29E-05 PYCARD, PML, TP53, SMAD3, STAT1, 466 54 1.15E-04 activity 5 8 1 8 5 MYC, NLRP1
BMP4, TNFRSF12A, FGF9, IL18, FGF10,
1.33333333 TBX1, TNFSF12, PTEN, TGFB2, 1352 3.53068089 0.03901855 0.02353 GO:0001525~angiogenesis 18 1.30E-05 466 148 1.17E-04 3 MAP3K7, NOTCH1, MEOX2, CTGF, 8 5 3 8
HAND2, PTK2B, VEGFA, ERAP1, IL1B
0.74074074 P2RX7, CRTAM, CD40LG, TP53, RIPK2, 1352 6.59773702 0.04485930 0.02714 GO:0070661~leukocyte proliferation 10 1.50E-05 466 44 1.34E-04 1 MALT1, CD40, IL7R, IL10, TGFB1 8 7 5 3
0.74074074 BMP4, NOG, BMP2, CD44, ILK, SIX1, 1352 6.59773702 0.04485930 0.02714 GO:0001656~metanephros development 10 1.50E-05 466 44 1.34E-04 1 SMAD4, PBX1, FOXC1, GLI3 8 7 5 3
GO:0032943~mononuclear cell 0.74074074 P2RX7, CRTAM, CD40LG, TP53, RIPK2, 1352 6.59773702 0.04485930 0.02714 10 1.50E-05 466 44 1.34E-04 proliferation 1 MALT1, CD40, IL7R, IL10, TGFB1 8 7 5 3
GO:0002573~myeloid leukocyte 0.66666666 CSF2, TNFSF11, TNF, RELB, IRF4, KIT, 1352 7.68442312 0.02732 9 1.51E-05 466 34 0.04515442 1.35E-04 differentiation 7 TRAF6, CHUK, TGFB1 8 5 6
GO:0001910~regulation of leukocyte 0.59259259 PVR, P2RX7, CRTAM, TAP2, STAT5B, 1352 9.28961373 0.04532406 0.02743 8 1.52E-05 466 25 1.35E-04 mediated cytotoxicity 3 KLRK1, IL7R, CD226 8 4 4 1
IRS2, LRSAM1, TNF, PTGS2, NFKBIE, GO:0051051~negative regulation of 1.25925925 1352 3.65563503 0.04684876 0.02837 17 1.57E-05 NFKBIB, PTGS1, NFKBIA, NFKB1, 466 135 1.39E-04 transport 9 8 4 5 6 FOXP3, PTEN, TRAT1, TGFB1, IL10, NEDD4, IL1B, NEDD4L
E2F1, THRA, TNF, PML, TGFB3, TP63,
NFKB1, PAWR, ZBTB16, PAX3, ZEB1,
SOX9, GLI2, GLI3, TGFB1, VDR, GO:0045934~negative regulation of 2.81481481 RUNX2, TWIST2, CIITA, EGR1, BMP2, 1352 2.15457349 0.04830804 0.02928 nucleobase, nucleoside, nucleotide and 38 1.62E-05 466 512 1.43E-04 5 RARG, RXRA, TP53, SMAD4, SMAD3, 8 8 9 2 nucleic acid metabolic process SMAD2, RB1, FOXP3, STAT3, CDKN1C,
MSX1, CDKN1B, NEDD4, IRF7, UBA3,
IRF8, IRF2
TNFRSF12A, IL7, STAT5B, SFN, TGFB2, GO:0045927~positive regulation of 0.96296296 1352 4.71738197 0.05057923 0.03069 13 1.70E-05 GH1, EP300, CHD7, PTK2B, PRSS2, ILK, 466 80 1.50E-04 growth 3 8 4 6 5 GHR, IL2
CAV1, TNFSF11, ATG5, IL7, ERBB2, 0.81481481 1352 5.70232985 0.05339566 0.03245 GO:0048771~tissue remodeling 11 1.80E-05 VEGFA, TGFB3, FGF10, TBX1, FOXC1, 466 56 1.58E-04 5 8 9 8 1 TGFB1
MAP3K7, BMP4, BCL10, SMO, FOXA2, 0.88888888 1352 0.05443363 GO:0021915~neural tube development 12 1.84E-05 PAX6, TFAP2A, PAX3, TRAF6, GLI2, 466 68 5.12294875 1.60E-04 0.0331 9 8 2 GLI3, VASP
TXNIP, PTGS2, RELA, PAX6, FGF10,
1.48148148 TP63, SFN, GLI2, SOX9, TGFB2, PTHLH, 1352 3.15543944 0.05671217 0.03452 GO:0008544~epidermis development 20 1.91E-05 466 184 1.67E-04 1 NOTCH1, CDKN2A, IRF6, CTGF, 8 8 6 6
MADCAM1, COL1A1, NGFR, EDA, APC
GO:0052031~modulation by symbiont of 1352 24.1917024 0.05793622 0.03529 5 0.37037037 1.96E-05 IRF7, TLR2, TLR3, TLR4, TLR7 466 6 1.70E-04 host defense response 8 3 3 4
GO:0002724~regulation of T cell MAP3K7, TRAF2, MALT1, TRAF6, 1352 24.1917024 0.05793622 0.03529 5 0.37037037 1.96E-05 466 6 1.70E-04 cytokine production FOXP3 8 3 3 4 GO:0052509~positive regulation by 1352 24.1917024 0.05793622 0.03529 5 0.37037037 1.96E-05 IRF7, TLR2, TLR3, TLR4, TLR7 466 6 1.70E-04 symbiont of host defense response 8 3 3 4
GO:0002755~MyD88-dependent toll-like 1352 24.1917024 0.05793622 0.03529 5 0.37037037 1.96E-05 IRAK2, IRAK1, IRAK3, MYD88, TLR2 466 6 1.70E-04 receptor signaling pathway 8 3 3 4
GO:0052255~modulation by organism of 1352 24.1917024 0.05793622 0.03529 defense response of other organism 5 0.37037037 1.96E-05 IRF7, TLR2, TLR3, TLR4, TLR7 466 6 1.70E-04 8 3 3 4 during symbiotic interaction
GO:0052510~positive regulation by 1352 24.1917024 0.05793622 0.03529 organism of defense response of other 5 0.37037037 1.96E-05 IRF7, TLR2, TLR3, TLR4, TLR7 466 6 1.70E-04 8 3 3 4 organism during symbiotic interaction
0.59259259 LRSAM1, DZIP3, UBE4A, FBXO4, 1352 8.93232089 0.05974656 0.03643 GO:0000209~protein polyubiquitination 8 2.02E-05 466 26 1.75E-04 3 UBE3C, UBOX5, TRAF6, UBE2B 8 8 6 1
GO:0001837~epithelial to mesenchymal 0.51851851 NOG, NOTCH1, BMP2, SOX9, TGFB1, 1352 11.2894611 0.06160069 0.03759 7 2.08E-05 466 18 1.80E-04 transition 9 NFATC1, TGFB2 8 3 5 9
0.81481481 VCAM1, EDNRB, IL6, TNF, CD34, SAA1, 1352 5.60228898 0.06249606 0.03816 GO:0050900~leukocyte migration 11 2.12E-05 466 57 1.82E-04 5 IFNG, IL1B, IL10, TGFB2, SYK 8 4 1 3
CRTAM, IL6, TNF, PANX1, TGFB3, GO:0051047~positive regulation of 1.11111111 1352 3.99496003 0.06305349 0.03851 15 2.14E-05 TGFB1, IL10, TGFB2, P2RX7, SAA1, 466 109 1.83E-04 secretion 1 8 5 2 5 IFNG, PYCARD, IL1A, SYK, IL2
GO:0048660~regulation of smooth 0.74074074 EGFR, IL6, TNF, PTGS2, ILK, VEGFA, 1352 6.31087889 0.06490088 0.03968 10 2.20E-05 466 46 1.88E-04 muscle cell proliferation 1 IFNG, STAT5B, STAT1, AGER 8 5 3 1
IRS2, EGR2, SOCS3, RXRA, RELA,
GO:0043434~response to peptide 1.33333333 STAT5B, SOCS1, PRKDC, STAT1, IRS1, 1352 0.03977 18 2.21E-05 466 154 3.3931219 0.06505578 1.88E-04 hormone stimulus 3 UBE2B, IL10, STAT3, GH1, IGF1R, 8 9
COL1A1, PTPN1, GHR
GO:0009991~response to extracellular 22 1.62962963 2.35E-05 BMP4, CAV1, BMP2, RARG, PTGS2, 466 220 1352 2.90300429 0.06909517 2.00E-04 0.04233 stimulus SOCS3, RXRA, RELA, TP53, STAT1, 8 2 7 9
PTEN, TGFB1, FOS, VDR, P2RX7,
CDKN1A, ATG5, CD44, IL1B, RARA,
COL1A1, GHR
IRS2, TNF, RELA, IRS1, IL10, IRAK3, GO:0009894~regulation of catabolic 1.03703703 1352 4.23354792 0.06963511 0.04268 14 2.37E-05 CBLB, NEDD4, APOE, IFNG, TRIM32, 466 96 2.01E-04 process 7 8 6 4 2 IL1B, NEDD4L, APC
0.66666666 EDNRB, NOTCH1, FGF9, RXRA, TGFB3, 1352 0.06992774 0.04286 GO:0048565~gut development 9 2.38E-05 466 36 7.25751073 2.01E-04 7 FGF10, GLI2, GLI3, TGFB1 8 6 8
STAT5B, TGFB1, EDNRB, APOE, SAA1,
IFNG, ILK, IL1B, FAS, MYC, IL1A, IRS2,
EGR2, TP53, RB1, IRS1, PTHLH, EP300,
CCR6, VEGFA, CCR2, TXN, RYR1,
CAV1, ERBB2, PRKDC, IL7R, VDR, 1352 1.89410399 0.07010196 0.04297 GO:0042592~homeostatic process 49 3.62962963 2.38E-05 466 751 2.01E-04 PTK2B, CAMK2D, FBXO4, NEDD4L, 8 9 7 9
APC, BMP4, IL6, IL2RA, IL7, SMAD5,
CREBBP, SMAD1, FOXP3, STAT3,
P2RX7, TNFSF11, MT2A, IKBKG,
IKBKB, IFI6, IL2
MLL, FOXA2, SMAD4, PAX6, PRKDC,
GO:0009952~anterior/posterior pattern 1.25925925 SMAD2, TBX1, ZBTB16, GLI3, NOTCH1, 1352 0.07310196 17 2.49E-05 466 140 3.52507664 2.10E-04 0.04489 formation 9 CRKL, EP300, MEOX2, LRP6, ROR2, 8 5
PBX1, APC
NOG, RARG, MLL, FGF9, TGFB3, GO:0048568~embryonic organ 1.40740740 1352 3.20680706 0.07731923 0.04758 19 2.64E-05 FGF10, TBX1, ZEB1, GLI2, GLI3, CHD7, 466 172 2.22E-04 development 7 8 7 1 6 DLX5, VEGFA, SIX1, FOXG1, TFAP2A, ROR2, PBX1, MYC
GO:0045428~regulation of nitric oxide 0.59259259 EGFR, CAV1, TNF, TICAM1, IFNG, 1352 8.60149419 0.07755167 0.04773 8 2.65E-05 466 27 2.22E-04 biosynthetic process 3 KLRK1, IL1B, IL10 8 8 2 4
GO:0045732~positive regulation of 0.59259259 CBLB, TNF, NEDD4, APOE, TRIM32, 1352 8.60149419 0.07755167 0.04773 8 2.65E-05 466 27 2.22E-04 protein catabolic process 3 IFNG, IL1B, APC 8 8 2 4
GO:0033077~T cell differentiation in the 0.59259259 CARD11, STAT5B, JAG2, TP53, PRKDC, 1352 8.60149419 0.07755167 0.04773 8 2.65E-05 466 27 2.22E-04 thymus 3 FAS, HLA-DMA, APC 8 8 2 4
THRA, STAT5B, TGFB3, TLR2, FGF10,
TLR3, TLR4, TGFB1, IL10, CBFB,
MYD88, CDKN2A, GATA3, IFNG, IL1B,
RARA, TWIST2, PITX2, CIITA, BCL10,
RARG, RELA, RXRA, RELB, PTHLH,
MSX1, EP300, CCR6, SIX1, VEGFA,
FOXG1, RIPK2, TFAP2A, PIAS1, ERC1,
EDA, LITAF, NFKBIA, SOX4, KEAP1,
SOX9, IRAK3, VDR, RUNX2, BMP4, 9.33333333 1352 1.40629965 0.07785608 GO:0045449~regulation of transcription 126 2.66E-05 BMP2, MLL, CREBBP, SMAD5, SMAD4, 466 2601 2.22E-04 0.04793 3 8 7 8 SMAD3, MALT1, SMAD2, SMAD1,
FOXP3, CDKN1C, NOTCH1, CDKN1B,
NEDD4, DLX5, IKBKG, UBA3, IKBKB,
E2F1, FOXA2, PAX6, TP63, NFKB1,
ZEB1, PAX3, PAWR, NFKB2, GLI2,
GLI3, FOS, PAX9, TICAM1, MYC, EGR1,
IRAK2, NFKBIZ, IRAK1, EGR2, SOX11,
TP53, RB1, ESR2, UBE2N, CARD11,
IFNAR2, RIPK1, FOXC1, TNF, PML, PRKDC, ZBTB16, HIC1, TNFRSF1A,
CHD7, REL, NR1D1, HAND2, PYCARD,
CAMK2A, NFATC1, TXNIP, IL6, IL5,
TBX1, STAT1, STAT3, TP73, STAT2,
IRF9, MEOX2, IRF5, IRF6, IRF7, IRF8,
IRF1, IRF2, IRF3, PBX1, IRF4, JAK3, IL2
TRAF1, TRAF2, CAV1, PML, TP63,
CDH1, HLA-DMA, TGFB1, TAPBP,
IGF1R, TNFRSF1A, NOD1, PTK2B,
2.74074074 TAP2, IL1RAP, ILK, FAS, MYC, SYK, 1352 0.08273299 0.05106 GO:0006461~protein complex assembly 37 2.83E-05 466 505 2.12695364 2.36E-04 1 APC, BCL10, IRAK1, MLL, CREBBP, 8 4 4
SMAD4, TP53, SMAD3, MALT1, SMAD2,
SMAD1, CD40, IRS1, TRIM21, P2RX7,
TNFSF11, PRLR, IRF7
TRAF1, TRAF2, CAV1, PML, TP63,
CDH1, HLA-DMA, TGFB1, TAPBP,
IGF1R, TNFRSF1A, NOD1, PTK2B,
2.74074074 TAP2, IL1RAP, ILK, FAS, MYC, SYK, 1352 0.08273299 0.05106 GO:0070271~protein complex biogenesis 37 2.83E-05 466 505 2.12695364 2.36E-04 1 APC, BCL10, IRAK1, MLL, CREBBP, 8 4 4
SMAD4, TP53, SMAD3, MALT1, SMAD2,
SMAD1, CD40, IRS1, TRIM21, P2RX7,
TNFSF11, PRLR, IRF7
RNASEL, TOLLIP, TBK1, TGFB3,
3.77777777 PRKG1, TGFB1, TGFB2, MAP3K7, IFNG, 1352 1.85066523 0.08309010 0.05129 GO:0016310~phosphorylation 51 2.84E-05 466 800 2.36E-04 8 ILK, IL1B, CHUK, IP6K2, SYK, GHR, 8 6 6 5
EGFR, IRAK2, IRAK1, RIPK1, CD81, ROR2, RIPK2, EIF2AK2, ERC1,
MAP3K14, FGFR2, FGFR1, TNF, STK11,
CAMK2G, ERBB2, PML, PRKDC, KIT,
IRAK4, IGF1R, IRAK3, MAP3K3, PTK2B,
CAMK2D, CAMK2B, CAMK2A, BMP2,
HCK, SMAD2, STAT1, IKBKE, P2RX7,
PRLR, JAK3, IKBKB
IRAK2, PTHLH, IRAK1, IRAK3, SMO, GO:0051100~negative regulation of 0.81481481 1352 5.41238088 0.08450946 11 2.89E-05 NOG, CDKN2A, THRA, NFKBIA, PBX1, 466 59 2.40E-04 0.05221 binding 5 8 3 3 FOXP3
SMO, NOTCH1, BMP2, TNFRSF12A, GO:0050769~positive regulation of 0.81481481 1352 5.41238088 0.08450946 11 2.89E-05 RELA, ILK, FOXG1, PAX6, SMAD1, KIT, 466 59 2.40E-04 0.05221 neurogenesis 5 8 3 3 NGFR
CDKN2A, NOD1, TNF, TNFRSF10B, GO:0043280~positive regulation of 0.81481481 1352 5.41238088 0.08450946 11 2.89E-05 PYCARD, PML, TP53, SMAD3, STAT1, 466 59 2.40E-04 0.05221 caspase activity 5 8 3 3 MYC, NLRP1
CDKN2A, NOD1, TNF, TNFRSF10B, GO:0010952~positive regulation of 0.81481481 1352 5.41238088 0.08450946 11 2.89E-05 PYCARD, PML, TP53, SMAD3, STAT1, 466 59 2.40E-04 0.05221 peptidase activity 5 8 3 3 MYC, NLRP1
EGFR, IRS2, IL6, STAT5B, SMAD3, KIT, GO:0051272~positive regulation of cell 1.03703703 1352 4.14714898 0.08632648 0.05338 14 2.96E-05 IRS1, TGFB1, TGFB2, IGF1R, PTK2B, 466 98 2.45E-04 motion 7 8 8 8 5 VEGFA, ILK, APC
GO:0046006~regulation of activated T 0.44444444 IL2RA, IL18, STAT5B, FOXP3, ICOSLG, 1352 14.5150214 0.08868618 0.05491 6 3.04E-05 466 12 2.51E-04 cell proliferation 4 IL2 8 6 2 4
0.44444444 EGFR, PAX6, TGFB3, EDA, TGFB1, 1352 14.5150214 0.08868618 0.05491 GO:0007431~salivary gland development 6 3.04E-05 466 12 2.51E-04 4 TGFB2 8 6 2 4 EGFR, IRAK1, ERBB2, CAMK2G, KIT, GO:0046777~protein amino acid 0.96296296 1352 4.43988891 0.09247238 0.05737 13 3.18E-05 IGF1R, MAP3K3, RIPK1, CAMK2D, 466 85 2.62E-04 autophosphorylation 3 8 7 9 5 CAMK2B, EIF2AK2, CAMK2A, SYK
WNT5A, NOG, RARG, FGF9, TP63, 1.03703703 1352 4.10525859 0.09582907 0.05956 GO:0035107~appendage morphogenesis 14 3.30E-05 FGF10, ZBTB16, GLI3, NOTCH1, CHD7, 466 99 2.71E-04 7 8 5 1 5 MSX1, DLX5, LRP6, PBX1
WNT5A, NOG, RARG, FGF9, TP63, 1.03703703 1352 4.10525859 0.09582907 0.05956 GO:0035108~limb morphogenesis 14 3.30E-05 FGF10, ZBTB16, GLI3, NOTCH1, CHD7, 466 99 2.71E-04 7 8 5 1 5 MSX1, DLX5, LRP6, PBX1
CAV1, IL6, IL2RA, PTGS2, STAT5B,
GO:0032101~regulation of response to 1.33333333 SMAD3, FGF10, TLR4, AGER, TGFB1, 1352 3.28641995 0.09688097 0.06025 18 3.34E-05 466 159 2.73E-04 external stimulus 3 IL10, TNFRSF1A, TNFRSF1B, SAA1, 8 3 5 3
APOE, VEGFA, LBP, IL2
0.59259259 P2RX7, IL2RA, IKBKG, STAT5B, FAS, 1352 8.29429797 0.09919874 0.06177 GO:0002260~lymphocyte homeostasis 8 3.43E-05 466 28 2.79E-04 3 IKBKB, FOXP3, TGFB1 8 7 8 2
BCL10, CAV1, IL2RA, STAT5B, TGFB1, GO:0032844~regulation of homeostatic 1.11111111 1352 3.81974248 0.10290219 0.06420 15 3.56E-05 P2RX7, TNFSF11, CD44, IFNG, VEGFA, 466 114 2.90E-04 process 1 8 9 2 7 RYR1, INPP5D, MYC, IFI6, IL2
TNF, FGF9, TP53, TGFB3, PML, FGF10, 0.96296296 1352 4.38826230 0.10355371 0.06463 GO:0006606~protein import into nucleus 13 3.58E-05 NFKBIA, GLI3, TGFB1, TGFB2, CBLB, 466 86 2.91E-04 3 8 2 3 7 IFNG, PRL
0.66666666 CDKN1A, CAV1, IL6, PTK2B, RIPK1, 1352 6.87553648 0.06521 GO:0045767~regulation of anti-apoptosis 9 3.62E-05 466 38 0.10442552 2.93E-04 7 RARA, SMAD1, ERC1, CD28 8 1 2
NOG, BMP2, EGR2, EFNB1, RXRA, GO:0000904~cell morphogenesis 1.70370370 1352 2.73643847 0.10513013 0.06567 23 3.64E-05 ERBB2, PAX6, GLI2, SOX9, TGFB1, 466 244 2.94E-04 involved in differentiation 4 8 2 7 7 VASP, TGFB2, CUL3, IGF1R, NOTCH1, S100B, PVRL1, DLX5, ILK, FOXG1,
NGFR, NFATC1, APC
GO:0009896~positive regulation of 0.74074074 IRS2, CBLB, TNF, NEDD4, APOE, 1352 5.92449855 0.10791443 0.06751 10 3.74E-05 466 49 3.01E-04 catabolic process 1 TRIM32, IFNG, IL1B, IRS1, APC 8 5 9 9
WNT5A, NOG, RARG, FGF9, TP63, GO:0030326~embryonic limb 0.96296296 1352 4.33782250 0.11567418 0.07268 13 4.03E-05 ZBTB16, GLI3, NOTCH1, CHD7, MSX1, 466 87 3.23E-04 morphogenesis 3 8 5 1 3 DLX5, LRP6, PBX1
WNT5A, NOG, RARG, FGF9, TP63, GO:0035113~embryonic appendage 0.96296296 1352 4.33782250 0.11567418 0.07268 13 4.03E-05 ZBTB16, GLI3, NOTCH1, CHD7, MSX1, 466 87 3.23E-04 morphogenesis 3 8 5 1 3 DLX5, LRP6, PBX1
GO:0030890~positive regulation of B cell 0.51851851 CARD11, CDKN1A, IL5, IL7, TICAM1, 1352 10.1605150 0.11767274 7 4.10E-05 466 20 3.29E-04 0.07402 proliferation 9 CD40, IL2 8 2 1
0.51851851 PTHLH, TGFB3, COL1A1, SOX9, 1352 10.1605150 0.11767274 GO:0060349~bone morphogenesis 7 4.10E-05 466 20 3.29E-04 0.07402 9 RUNX2, TGFB1, GHR 8 2 1
GO:0050830~defense response to 0.51851851 P2RX7, IL6, NOD1, CARD9, HCK, RIPK2, 1352 10.1605150 0.11767274 7 4.10E-05 466 20 3.29E-04 0.07402 Gram-positive bacterium 9 LBP 8 2 1
GO:0030856~regulation of epithelial cell 0.59259259 CAV1, NOTCH1, PRLR, STAT5B, PAX6, 1352 8.00828770 0.12512007 8 4.38E-05 466 29 3.50E-04 0.07903 differentiation 3 TP63, ZEB1, APC 8 2 4
GO:0051781~positive regulation of cell 0.66666666 FGF8, FGF9, VEGFA, TGFB3, IL1B, 1352 6.69924067 0.12595849 0.07959 9 4.41E-05 466 39 3.51E-04 division 7 TGFB1, IL1A, TGFB2, APC 8 3 8 7
GO:0060558~regulation of calcidiol 1352 20.7357449 0.12669571 0.08009 5 0.37037037 4.44E-05 VDR, TNF, IFNG, IL1B, NFKB1 466 7 3.53E-04 1-monooxygenase activity 8 4 5 5
GO:0032743~positive regulation of MAP3K7, TRAF2, RIPK2, MALT1, 1352 20.7357449 0.12669571 0.08009 5 0.37037037 4.44E-05 466 7 3.53E-04 interleukin-2 production TRAF6 8 4 5 5
1352 20.7357449 0.12669571 0.08009 GO:0032494~response to peptidoglycan 5 0.37037037 4.44E-05 IRAK3, IL6, CARD9, NFKBIA, RIPK2 466 7 3.53E-04 8 4 5 5 GO:0045080~positive regulation of 1352 20.7357449 0.12669571 0.08009 5 0.37037037 4.44E-05 TNF, TICAM1, IFNG, TLR3, IL1B 466 7 3.53E-04 chemokine biosynthetic process 8 4 5 5
GO:0007435~salivary gland 1352 20.7357449 0.12669571 0.08009 5 0.37037037 4.44E-05 EGFR, PAX6, TGFB3, TGFB1, TGFB2 466 7 3.53E-04 morphogenesis 8 4 5 5
TNF, FGF9, TP53, TGFB3, PML, FGF10, 0.96296296 1352 4.28852906 0.12889056 0.08158 GO:0051170~nuclear import 13 4.52E-05 NFKBIA, GLI3, TGFB1, TGFB2, CBLB, 466 88 3.58E-04 3 8 7 9 2 IFNG, PRL
0.44444444 DEFA1B, DEFA5, DEFA4, DEFA3, 1352 13.3984813 0.13641024 0.08670 GO:0050832~defense response to fungus 6 4.81E-05 466 13 3.80E-04 4 DEFA1, TGFB1, S100A12 8 5 8 6
GO:0042522~regulation of tyrosine 0.44444444 1352 13.3984813 0.13641024 0.08670 6 4.81E-05 CSF2, GH1, IL3, CAV1, GHR, IL2 466 13 3.80E-04 phosphorylation of Stat5 protein 4 8 5 8 6
GO:0045086~positive regulation of 0.44444444 CARD11, STAT5B, IL1B, IRF4, IL1A, 1352 13.3984813 0.13641024 0.08670 6 4.81E-05 466 13 3.80E-04 interleukin-2 biosynthetic process 4 CD28 8 5 8 6
GO:0045191~regulation of isotype 0.44444444 1352 13.3984813 0.13641024 0.08670 6 4.81E-05 IFNG, TNFSF12, CD40, IL10, TGFB1, IL2 466 13 3.80E-04 switching 4 8 5 8 6
EGFR, E2F1, CAMK2G, RB1, CDC34,
GO:0051329~interphase of mitotic cell 1.03703703 CUL3, CDKN1C, CDKN1A, CDKN1B, 1352 3.94583107 0.14261198 0.09096 14 5.04E-05 466 103 3.98E-04 cycle 7 CDKN2A, CAMK2D, CAMK2B, 8 6 4 5
CAMK2A, NFATC1
EGFR, IRS2, IL6, SMAD3, KIT, IRS1, GO:0030335~positive regulation of cell 0.96296296 1352 4.24034334 0.14325659 13 5.07E-05 TGFB1, TGFB2, IGF1R, PTK2B, VEGFA, 466 89 3.98E-04 0.09141 migration 3 8 8 6 ILK, APC
NOG, RARG, FGF9, TGFB3, FGF10, GO:0048562~embryonic organ 1.18518518 1352 0.14630450 0.09351 16 5.19E-05 TBX1, ZEB1, GLI2, GLI3, CHD7, DLX5, 466 133 3.49233599 4.07E-04 morphogenesis 5 8 1 6 SIX1, FOXG1, TFAP2A, ROR2, MYC
GO:0043392~negative regulation of DNA 10 0.74074074 5.22E-05 IRAK2, PTHLH, IRAK1, IRAK3, SMO, 466 51 1352 5.69216527 0.14709365 4.08E-04 0.09406 binding 1 CDKN2A, THRA, NFKBIA, PBX1, FOXP3 8 8 1 2
0.74074074 BMP4, SMO, NOTCH1, FOXA2, SIX1, 1352 5.69216527 0.14709365 0.09406 GO:0001708~cell fate specification 10 5.22E-05 466 51 4.08E-04 1 FGF10, TBX1, SOX9, GLI2, GLI3 8 8 1 2
TNFRSF1A, TNFRSF1B, IL6, IL2RA, GO:0050727~regulation of inflammatory 0.88888888 1352 4.58369098 0.15065193 0.09653 12 5.35E-05 PTGS2, SAA1, APOE, STAT5B, TLR4, 466 76 4.18E-04 response 9 8 7 9 3 LBP, IL10, IL2
GO:0045768~positive regulation of 0.59259259 CDKN1A, CAV1, IL6, PTK2B, RIPK1, 1352 7.74134477 0.15568936 0.10004 8 5.55E-05 466 30 4.32E-04 anti-apoptosis 3 SMAD1, ERC1, CD28 8 8 7 7
GO:0042990~regulation of transcription 0.59259259 TNF, NFKBIE, NFKBIB, SMAD3, 1352 7.74134477 0.15568936 0.10004 8 5.55E-05 466 30 4.32E-04 factor import into nucleus 3 NFKBIA, CDH1, EDA, IL10 8 8 7 7
GO:0001912~positive regulation of 0.51851851 PVR, P2RX7, CRTAM, TAP2, STAT5B, 1352 9.67668097 0.15651451 0.10062 7 5.58E-05 466 21 4.33E-04 leukocyte mediated cytotoxicity 9 KLRK1, CD226 8 3 1 5
0.51851851 ULBP3, STAT5B, ULBP2, KIR2DS2, 1352 9.67668097 0.15651451 0.10062 GO:0030101~natural killer cell activation 7 5.58E-05 466 21 4.33E-04 9 KLRK1, KIR3DL1, IL2 8 3 1 5
CAV1, SFN, RB1, TP73, CDKN1C, GO:0033673~negative regulation of 0.96296296 1352 4.19322842 0.10224 13 5.67E-05 IRAK3, CDKN1A, CDKN1B, CDKN2A, 466 90 0.15882169 4.39E-04 kinase activity 3 8 2 4 APOE, ILK, IL1B, APC
GO:0002761~regulation of myeloid 0.66666666 IL5, TNFSF11, TNF, TLR3, KITLG, TLR4, 1352 6.37244844 0.17868039 0.11635 9 6.45E-05 466 41 4.98E-04 leukocyte differentiation 7 RB1, INPP5D, APC 8 6 5 9
GO:0050679~positive regulation of 0.66666666 EGFR, NOG, FGF9, ERBB2, DLX5, 1352 6.37244844 0.17868039 0.11635 9 6.45E-05 466 41 4.98E-04 epithelial cell proliferation 7 VEGFA, FGF10, PRL, TGFB1 8 6 5 9
EGFR, WNT5A, FGFR1, CAV1, TNF,
1.40740740 TGFB3, SMAD1, TAB1, MAP3K7, 1352 2.99766747 0.17907652 0.11664 GO:0000165~MAPKKK cascade 19 6.47E-05 466 184 4.98E-04 7 P2RX7, CRKL, MAP3K3, PTK2B, RIPK1, 8 5 5 4
CD81, ROR2, IL1B, SYK, GHR
GO:0051325~interphase 14 1.03703703 6.83E-05 EGFR, E2F1, CAMK2G, RB1, CDC34, 466 106 1352 3.83415661 0.18806055 5.25E-04 0.12314 7 CUL3, CDKN1C, CDKN1A, CDKN1B, 8 2 5 5
CDKN2A, CAMK2D, CAMK2B,
CAMK2A, NFATC1
GO:0048661~positive regulation of 0.59259259 EGFR, IL6, TNF, PTGS2, VEGFA, 1352 7.49162397 0.19118460 0.12542 8 6.96E-05 466 31 5.33E-04 smooth muscle cell proliferation 3 STAT5B, STAT1, AGER 8 9 7 2
GO:0045408~regulation of interleukin-6 0.44444444 CARD9, IFNG, TLR1, IL1B, INPP5D, 1352 12.4414469 0.19885271 0.13104 6 7.27E-05 466 14 5.56E-04 biosynthetic process 4 TRAF6 8 7 6 9
FGFR1, ERBB2, PAX6, CDH1, PRKG1,
GLI2, PTEN, IGF1R, PVRL1, CD44,
2.14814814 PTK2B, ILK, SH2B1, APC, EGFR, IL6, 1352 0.19946495 0.13150 GO:0030030~cell projection organization 29 7.29E-05 466 368 2.2876936 5.56E-04 8 EGR2, RXRA, EFNB1, UBE2B, VASP, 8 9 1
SMO, P2RX7, NOTCH1, S100B, NEDD4,
DLX5, FOXG1, NGFR
CAV1, TNF, IL18, PML, PRKDC, TLR3,
KIT, TGFB1, FOS, PTK2B, IL1B, MYC,
2.14814814 TXNIP, BMP4, EGFR, BMP2, UBE2A, 1352 0.19946495 0.13150 GO:0009628~response to abiotic stimulus 29 7.29E-05 466 368 2.2876936 5.56E-04 8 SOCS3, RELA, TP53, STAT1, UBE2B, 8 9 1
CDKN1A, P2RX7, TNFSF11, NEDD4,
COL1A1, NGFR, ICOSLG
0.66666666 NOTCH1, PTGS2, RELA, TP63, NGFR, 1352 6.22072348 0.21017209 0.13945 GO:0022404~molting cycle process 9 7.74E-05 466 42 5.88E-04 7 SOX9, EDA, TGFB2, APC 8 3 1 5
0.66666666 P2RX7, CRTAM, CD40LG, TP53, RIPK2, 1352 6.22072348 0.21017209 0.13945 GO:0046651~lymphocyte proliferation 9 7.74E-05 466 42 5.88E-04 7 MALT1, CD40, IL7R, IL10 8 3 1 5
0.66666666 NOTCH1, PTGS2, RELA, TP63, NGFR, 1352 6.22072348 0.21017209 0.13945 GO:0001942~hair follicle development 9 7.74E-05 466 42 5.88E-04 7 SOX9, EDA, TGFB2, APC 8 3 1 5
GO:0022405~hair cycle process 9 0.66666666 7.74E-05 NOTCH1, PTGS2, RELA, TP63, NGFR, 466 42 1352 6.22072348 0.21017209 5.88E-04 0.13945 7 SOX9, EDA, TGFB2, APC 8 3 1 5
BMP4, VDR, BMP2, RARG, PTGS2, 0.81481481 1352 4.83834048 0.21271925 0.14136 GO:0033273~response to vitamin 11 7.84E-05 CD44, RELA, RXRA, IL1B, RARA, 466 66 5.95E-04 5 8 6 3 2 TGFB1
GO:0002495~antigen processing and IFI30, TRAF6, HLA-DOA, HLA-DMA, 1352 18.1437768 0.23170698 0.15578 presentation of peptide antigen via MHC 5 0.37037037 8.64E-05 466 8 6.54E-04 HLA-DRA 8 2 5 1 class II
GO:0007183~SMAD protein complex SMAD4, SMAD3, SMAD2, SMAD1, 1352 18.1437768 0.23170698 0.15578 5 0.37037037 8.64E-05 466 8 6.54E-04 assembly TGFB1 8 2 5 1
GO:0030889~negative regulation of B 1352 18.1437768 0.23170698 0.15578 5 0.37037037 8.64E-05 BTLA, CDKN2A, PAWR, INPP5D, IL10 466 8 6.54E-04 cell proliferation 8 2 5 1
GO:0019886~antigen processing and IFI30, TRAF6, HLA-DOA, HLA-DMA, 1352 18.1437768 0.23170698 0.15578 presentation of exogenous peptide antigen 5 0.37037037 8.64E-05 466 8 6.54E-04 HLA-DRA 8 2 5 1 via MHC class II
GO:0010551~regulation of specific CIITA, THRA, FOXA2, RXRA, TP53, 0.96296296 1352 0.23383141 0.15741 transcription from RNA polymerase II 13 8.73E-05 PRKDC, SMAD3, NFKBIA, NFKB1, 466 94 4.01479317 6.59E-04 3 8 1 6 promoter FOXP3, VDR, NOTCH1, IRF4
TNF, FGF9, TP53, TGFB3, PML, FGF10, GO:0034504~protein localization in 0.96296296 1352 0.23383141 0.15741 13 8.73E-05 NFKBIA, GLI3, TGFB1, TGFB2, CBLB, 466 94 4.01479317 6.59E-04 nucleus 3 8 1 6 IFNG, PRL
0.66666666 NOTCH1, PTGS2, RELA, TP63, NGFR, 1352 6.07605549 0.24517371 0.16622 GO:0042303~molting cycle 9 9.22E-05 466 43 6.94E-04 7 SOX9, EDA, TGFB2, APC 8 5 3 3
0.66666666 NOTCH1, PTGS2, RELA, TP63, NGFR, 1352 6.07605549 0.24517371 0.16622 GO:0042633~hair cycle 9 9.22E-05 466 43 6.94E-04 7 SOX9, EDA, TGFB2, APC 8 5 3 3
0.96296296 NOG, FGF9, TGFB3, JAG2, FGF10, TBX1, 1352 3.97253218 0.25588125 0.17465 GO:0043583~ear development 13 9.69E-05 466 95 7.28E-04 3 TGFB1, CHD7, CDKN1B, DLX5, SIX1, 8 9 2 9 FOXG1, MYC
GO:0042531~positive regulation of 0.51851851 1352 8.83523045 0.25818600 0.17649 7 9.79E-05 CSF2, GH1, IL3, IL6, IFNG, GHR, IL2 466 23 7.34E-04 tyrosine phosphorylation of STAT protein 9 8 3 6 1
CSH1, CSH2, PTGS2, RXRA, STAT5B, 1.03703703 1352 3.69473273 0.26395487 GO:0007565~female pregnancy 14 1.00E-04 TGFB3, TGFB1, PTHLH, LNPEP, FOS, 466 110 7.51E-04 0.1811 7 8 5 2 VDR, PRLR, IL1B, PRL
GO:0046627~negative regulation of 0.44444444 SOCS3, RELA, SOCS1, IL1B, PTPN1, 1352 11.6120171 0.27617892 0.19098 6 1.06E-04 466 15 7.90E-04 insulin receptor signaling pathway 4 IRS1 8 7 4 7
CAV1, SFN, RB1, TP73, CDKN1C, GO:0051348~negative regulation of 0.96296296 1352 3.93115164 0.27925283 13 1.07E-04 IRAK3, CDKN1A, CDKN1B, CDKN2A, 466 96 7.98E-04 0.1935 transferase activity 3 8 5 4 APOE, ILK, IL1B, APC
EGFR, IRS2, IL6, PAX6, JAG2, SMAD3,
1.40740740 FGF10, KIT, PTEN, AGER, IRS1, TGFB1, 1352 2.87276466 0.28978979 0.20219 GO:0040012~regulation of locomotion 19 1.12E-04 466 192 8.32E-04 7 TGFB2, IGF1R, APOE, PTK2B, ILK, 8 4 1 3
VEGFA, APC
EGFR, IRS2, IL6, STAT5B, PAX6, JAG2,
1.40740740 SMAD3, KIT, PTEN, IRS1, TGFB1, 1352 2.85787987 0.30626891 GO:0051270~regulation of cell motion 19 1.20E-04 466 193 8.87E-04 0.21605 7 TGFB2, IGF1R, CDKN1B, APOE, PTK2B, 8 3 2
ILK, VEGFA, APC
UBE2N, CAV1, P2RX7, CDKN1B, TNF, GO:0010638~positive regulation of 0.88888888 1352 4.19711463 0.30983334 12 1.22E-04 PML, SMAD3, IL1B, FOXP3, IL1A, CD28, 466 83 8.97E-04 0.21909 organelle organization 9 8 9 4 APC
GO:0002712~regulation of B cell 0.51851851 IFNG, TNFSF12, CD40, CD226, IL10, 1352 8.46709585 0.32073552 0.22848 7 1.27E-04 466 24 9.34E-04 mediated immunity 9 TGFB1, IL2 8 1 4 7
0.51851851 SOCS3, SOCS1, UBE2G2, HECTD3, 1352 8.46709585 0.32073552 0.22848 GO:0006512~ubiquitin cycle 7 1.27E-04 466 24 9.34E-04 9 NEDD4L, PARK2, ASB5 8 1 4 7 GO:0002889~regulation of 0.51851851 IFNG, TNFSF12, CD40, CD226, IL10, 1352 8.46709585 0.32073552 0.22848 immunoglobulin mediated immune 7 1.27E-04 466 24 9.34E-04 9 TGFB1, IL2 8 1 4 7 response
GO:0043433~negative regulation of 0.66666666 IRAK2, PTHLH, IRAK1, IRAK3, 1352 5.80600858 0.32542389 0.23257 9 1.29E-04 466 45 9.48E-04 transcription factor activity 7 CDKN2A, THRA, NFKBIA, PBX1, FOXP3 8 4 5 4
BMP4, CUL3, FGF8, FOXA2, SMAD4, 0.81481481 1352 4.56186388 0.32822265 0.23502 GO:0007369~gastrulation 11 1.30E-04 LRP6, TP53, SMAD3, SMAD2, FOXC1, 466 70 9.56E-04 5 8 7 5 7 SMAD1
E2F1, EGR1, CIITA, RARG, TNF, RXRA, GO:0000122~negative regulation of 1.70370370 TP53, SMAD3, TP63, NFKB1, RB1, ZEB1, 1352 2.51011649 0.33006474 0.23664 transcription from RNA polymerase II 23 1.31E-04 466 266 9.60E-04 4 PAWR, PAX3, GLI2, STAT3, CDKN1C, 8 3 8 8 promoter VDR, MSX1, NEDD4, IRF7, IRF8, IRF2
GO:0032088~negative regulation of 0.44444444 IRAK2, IRAK1, IRAK3, CDKN2A, 1352 10.8862660 0.36676547 0.26988 6 1.50E-04 466 16 0.0010925 NF-kappaB transcription factor activity 4 NFKBIA, FOXP3 8 9 7 7
GO:0045911~positive regulation of DNA 1352 16.1278016 0.36971670 0.27264 5 0.37037037 1.51E-04 IFNG, TNFSF12, CD40, TGFB1, IL2 466 9 0.00110103 recombination 8 2 8 3
GO:0042104~positive regulation of 1352 16.1278016 0.36971670 0.27264 5 0.37037037 1.51E-04 IL2RA, IL18, STAT5B, ICOSLG, IL2 466 9 0.00110103 activated T cell proliferation 8 2 8 3
GO:0045830~positive regulation of 1352 16.1278016 0.36971670 0.27264 5 0.37037037 1.51E-04 IFNG, TNFSF12, CD40, TGFB1, IL2 466 9 0.00110103 isotype switching 8 2 8 3
GO:0043011~myeloid dendritic cell 1352 16.1278016 0.36971670 0.27264 5 0.37037037 1.51E-04 CSF2, RELB, IRF4, TRAF6, TGFB1 466 9 0.00110103 differentiation 8 2 8 3
GO:0001773~myeloid dendritic cell 1352 16.1278016 0.36971670 0.27264 5 0.37037037 1.51E-04 CSF2, RELB, IRF4, TRAF6, TGFB1 466 9 0.00110103 activation 8 2 8 3
GO:0044003~modification by symbiont 1352 16.1278016 0.36971670 0.27264 5 0.37037037 1.51E-04 IRF7, TLR2, TLR3, TLR4, TLR7 466 9 0.00110103 of host morphology or physiology 8 2 8 3 NOTCH1, CDKN2A, ZBTB16, KIT, 1352 16.1278016 0.36971670 0.27264 GO:0017145~stem cell division 5 0.37037037 1.51E-04 466 9 0.00110103 TGFB2 8 2 8 3
GO:0018108~peptidyl-tyrosine 0.66666666 PRLR, PTK2B, ERBB2, IFNG, JAK3, KIT, 1352 5.67979100 0.37024624 0.00110040 0.27313 9 1.52E-04 466 46 phosphorylation 7 STAT1, GHR, SYK 8 6 3 9 8
BMP4, CAV1, BMP2, RARG, PTGS2,
1.40740740 SOCS3, RXRA, RELA, TP53, STAT1, 1352 2.79985185 0.37770992 0.00112608 0.28017 GO:0031667~response to nutrient levels 19 1.56E-04 466 197 7 PTEN, TGFB1, VDR, ATG5, CD44, IL1B, 8 5 4 5 1
RARA, COL1A1, GHR
GO:0045356~positive regulation of 0.29629629 1352 29.0300429 0.38109961 0.00113634 0.28339 4 1.57E-04 TLR3, TLR7, TLR8, TLR9 466 4 interferon-alpha biosynthetic process 6 8 2 6 7 2
GO:0070391~response to lipoteichoic 0.29629629 1352 29.0300429 0.38109961 0.00113634 0.28339 4 1.57E-04 TLR2, RIPK2, LBP, CD14 466 4 acid 6 8 2 6 7 2
GO:0070498~interleukin-1-mediated 0.29629629 1352 29.0300429 0.38109961 0.00113634 0.28339 4 1.57E-04 IRAK2, IRAK1, IRAK3, IL1R1 466 4 signaling pathway 6 8 2 6 7 2
GO:0045351~type I interferon 0.29629629 1352 29.0300429 0.38109961 0.00113634 0.28339 4 1.57E-04 IRF9, MYD88, IRF3, IFNAR1 466 4 biosynthetic process 6 8 2 6 7 2
0.29629629 1352 29.0300429 0.38109961 0.00113634 0.28339 GO:0032606~type I interferon production 4 1.57E-04 IRF9, MYD88, IRF3, IFNAR1 466 4 6 8 2 6 7 2
IRS2, EGR2, SOCS3, RXRA, RELA, 0.96296296 1352 3.77390557 0.38521156 0.00114940 0.28732 GO:0032868~response to insulin stimulus 13 1.59E-04 PRKDC, STAT1, UBE2B, IRS1, IL10, 466 100 3 8 9 2 3 4 IGF1R, PTPN1, GHR
GO:0050777~negative regulation of 0.51851851 IRAK3, CTLA4, INPP5D, IL7R, FOXP3, 1352 8.12841201 0.38996268 0.29189 7 1.62E-04 466 25 0.00116497 immune response 9 TGFB1, TGFB2 8 7 7 9
GO:0045669~positive regulation of 0.51851851 BMP4, IL6, BMP2, DLX5, SMAD5, 1352 8.12841201 0.38996268 0.29189 7 1.62E-04 466 25 0.00116497 osteoblast differentiation 9 SMAD1, RUNX2 8 7 7 9
GO:0050680~negative regulation of 7 0.51851851 1.62E-04 CDKN1C, CDKN1B, PAX6, ESR2, 466 25 1352 8.12841201 0.38996268 0.00116497 0.29189 epithelial cell proliferation 9 TGFB1, TGFB2, APC 8 7 7 9
GO:0032768~regulation of 0.51851851 EGFR, VDR, TNF, APOE, IFNG, IL1B, 1352 8.12841201 0.38996268 0.29189 7 1.62E-04 466 25 0.00116497 monooxygenase activity 9 NFKB1 8 7 7 9
RNASEL, TOLLIP, TBK1, TGFB3,
PRKG1, PTEN, TGFB1, TGFB2, MAP3K7,
ILK, IFNG, IL1B, CHUK, IP6K2, SYK,
GHR, EGFR, IRAK2, IRAK1, INPPL1,
RIPK1, CD81, ROR2, RIPK2, EIF2AK2,
GO:0006793~phosphorus metabolic 4.14814814 ERC1, MAP3K14, FGFR2, FGFR1, TNF, 1352 1.67079383 0.40947928 0.00123864 0.31107 56 1.73E-04 466 973 process 8 STK11, CAMK2G, ERBB2, PML, PRKDC, 8 7 4 5 3
KIT, IRAK4, IGF1R, IRAK3, MAP3K3,
PTK2B, CAMK2D, CAMK2B, INPP5D,
CAMK2A, PTPN6, BMP2, HCK, SMAD2,
STAT1, IKBKE, P2RX7, PRLR, JAK3,
PTPN1, IKBKB
RNASEL, TOLLIP, TBK1, TGFB3,
PRKG1, PTEN, TGFB1, TGFB2, MAP3K7,
ILK, IFNG, IL1B, CHUK, IP6K2, SYK,
GHR, EGFR, IRAK2, IRAK1, INPPL1,
RIPK1, CD81, ROR2, RIPK2, EIF2AK2, GO:0006796~phosphate metabolic 4.14814814 1352 1.67079383 0.40947928 0.00123864 0.31107 56 1.73E-04 ERC1, MAP3K14, FGFR2, FGFR1, TNF, 466 973 process 8 8 7 4 5 3 STK11, CAMK2G, ERBB2, PML, PRKDC,
KIT, IRAK4, IGF1R, IRAK3, MAP3K3,
PTK2B, CAMK2D, CAMK2B, INPP5D,
CAMK2A, PTPN6, BMP2, HCK, SMAD2,
STAT1, IKBKE, P2RX7, PRLR, JAK3, PTPN1, IKBKB
0.66666666 FGF8, FGF9, VEGFA, TGFB3, IL1B, 1352 5.55894438 0.41770362 0.00126862 0.31934 GO:0051302~regulation of cell division 9 1.77E-04 466 47 7 TGFB1, IL1A, TGFB2, APC 8 9 9 1 2
IRAK3, CDKN1A, CAV1, CDKN1B, GO:0006469~negative regulation of 0.88888888 1352 4.00414385 0.43377460 0.00133111 0.33584 12 1.86E-04 CDKN2A, APOE, ILK, IL1B, RB1, SFN, 466 87 protein kinase activity 9 8 1 5 1 2 TP73, APC
GO:0002263~cell activation during 0.59259259 RELB, TICAM1, TLR2, TP53, TLR3, 1352 6.45112064 0.44043278 0.00135560 0.34281 8 1.90E-04 466 36 immune response 3 TLR4, LBP, TLR7 8 9 8 3 4
GO:0002366~leukocyte activation during 0.59259259 RELB, TICAM1, TLR2, TP53, TLR3, 1352 6.45112064 0.44043278 0.00135560 0.34281 8 1.90E-04 466 36 immune response 3 TLR4, LBP, TLR7 8 9 8 3 4
GO:0009953~dorsal/ventral pattern 0.74074074 BMP4, SMO, NOG, FOXA2, FOXG1, 1352 4.83834048 0.44458315 0.00136977 0.34720 10 1.93E-04 466 60 formation 1 PAX6, SMAD2, GLI2, GLI3, APC 8 6 1 5 3
GO:0000018~regulation of DNA 0.51851851 IFNG, TNFSF12, CD40, IL7R, IL10, 1352 7.81578078 0.46422228 0.00145019 0.36841 7 2.05E-04 466 26 recombination 9 TGFB1, IL2 8 6 7 4 9
GO:0060070~Wnt receptor signaling 0.44444444 RARG, LRP6, SOX4, UBE2B, AXIN1, 1352 0.46694208 0.00145862 0.37141 6 2.06E-04 466 17 10.2458975 pathway through beta-catenin 4 APC 8 9 2 8
GO:0042307~positive regulation of 0.44444444 1352 0.46694208 0.00145862 0.37141 6 2.06E-04 SMO, TNF, SMAD3, CDH1, EDA, GLI3 466 17 10.2458975 protein import into nucleus 4 8 9 2 8
GO:0032732~positive regulation of 0.44444444 P2RX7, PANX1, SAA1, IFNG, PYCARD, 1352 0.46694208 0.00145862 0.37141 6 2.06E-04 466 17 10.2458975 interleukin-1 production 4 SMAD3 8 9 2 8
GO:0045793~positive regulation of cell 0.66666666 EP300, TNFRSF12A, PTK2B, PRSS2, ILK, 1352 5.44313304 0.46725789 0.00145661 0.37176 9 2.06E-04 466 48 size 7 SFN, TP73, IL2, TGFB2 8 7 6 8 7
GO:0018212~peptidyl-tyrosine 0.66666666 PRLR, PTK2B, ERBB2, IFNG, JAK3, KIT, 1352 5.44313304 0.46725789 0.00145661 0.37176 9 2.06E-04 466 48 modification 7 STAT1, GHR, SYK 8 7 6 8 7
0.59259259 EDNRB, IL6, SAA1, IFNG, IL1B, IL10, 1352 6.27676603 0.50099299 0.00160410 0.41030 GO:0030595~leukocyte chemotaxis 8 2.28E-04 466 37 3 TGFB2, SYK 8 6 7 5 9 EGFR, IRS2, IL6, PAX6, JAG2, SMAD3, 1.25925925 1352 2.92018183 0.00167210 0.42866 GO:0030334~regulation of cell migration 17 2.38E-04 KIT, PTEN, IRS1, TGFB1, TGFB2, IGF1R, 466 169 0.51630464 9 8 2 3 4 PTK2B, APOE, ILK, VEGFA, APC
GO:0042088~T-helper 1 type immune 1352 14.5150214 0.52691658 0.00171917 0.44172 5 0.37037037 2.45E-04 IL18, RELB, VEGFA, TLR4, TRAF6 466 10 response 8 6 8 2 8
GO:0050856~regulation of T cell receptor 1352 14.5150214 0.52691658 0.00171917 0.44172 5 0.37037037 2.45E-04 BCL10, CBLB, MALT1, PAWR, TRAT1 466 10 signaling pathway 8 6 8 2 8
GO:0033138~positive regulation of 1352 14.5150214 0.52691658 0.00171917 0.44172 5 0.37037037 2.45E-04 CAV1, IL6, IFNG, TGFB1, AXIN1 466 10 peptidyl-serine phosphorylation 8 6 8 2 8
GO:0002720~positive regulation of MAP3K7, TRAF2, BCL10, MALT1, 1352 14.5150214 0.52691658 0.00171917 0.44172 cytokine production during immune 5 0.37037037 2.45E-04 466 10 TRAF6 8 6 8 2 8 response
GO:0042523~positive regulation of 1352 14.5150214 0.52691658 0.00171917 0.44172 5 0.37037037 2.45E-04 CSF2, GH1, IL3, GHR, IL2 466 10 tyrosine phosphorylation of Stat5 protein 8 6 8 2 8
NOG, ERBB2, PAX6, IL7R, SOX9, GLI2,
TGFB1, TGFB2, CUL3, IGF1R, PVRL1, 1352 2.20171673 0.53587310 0.00175899 0.45298 GO:0000902~cell morphogenesis 27 2 2.52E-04 ILK, NFATC1, APC, EGFR, BMP2, EGR2, 466 356 8 8 2 5 3 RXRA, EFNB1, VASP, SMO, P2RX7,
NOTCH1, S100B, DLX5, FOXG1, NGFR
0.44444444 1352 9.67668097 0.57115967 0.00193558 GO:0009595~detection of biotic stimulus 6 2.78E-04 CRTAM, NOD1, TLR3, TLR4, LBP, TLR8 466 18 0.49953 4 8 3 5 6
GO:0002275~myeloid cell activation 0.44444444 1352 9.67668097 0.57115967 0.00193558 6 2.78E-04 TICAM1, TLR2, TLR3, TLR4, LBP, TLR7 466 18 0.49953 during immune response 4 8 3 5 6
GO:0010464~regulation of mesenchymal 0.44444444 1352 9.67668097 0.57115967 0.00193558 6 2.78E-04 IRS2, FGF9, VEGFA, TP63, ZEB1, IRS1 466 18 0.49953 cell proliferation 4 8 3 5 6
GO:0030501~positive regulation of bone 6 0.44444444 2.78E-04 BMP4, P2RX7, BMP2, TGFB3, SMAD3, 466 18 1352 9.67668097 0.57115967 0.00193558 0.49953 mineralization 4 TGFB1 8 3 5 6
GO:0050869~negative regulation of B 0.44444444 BTLA, CDKN2A, PAWR, FAS, INPP5D, 1352 9.67668097 0.57115967 0.00193558 6 2.78E-04 466 18 0.49953 cell activation 4 IL10 8 3 5 6
TNFRSF12A, APOE, ILK, SMAD4, GO:0010769~regulation of cell 0.81481481 1352 4.14714898 0.58853922 0.00202543 0.52387 11 2.91E-04 TGFB3, SMAD3, SMAD2, SMAD1, 466 77 morphogenesis involved in differentiation 5 8 8 1 8 4 NGFR, TGFB1, TGFB2
TNFRSF1A, IL6, VEGFA, STAT5B, GO:0032103~positive regulation of 0.74074074 1352 4.53594420 0.62104539 0.00220789 0.57228 10 3.18E-04 SMAD3, FGF10, TLR4, LBP, AGER, 466 64 response to external stimulus 1 8 6 1 8 4 TGFB1
0.59259259 EDNRB, IL6, SAA1, IFNG, IL1B, IL10, 1352 5.95488059 0.00222192 0.57722 GO:0060326~cell chemotaxis 8 3.21E-04 466 39 0.62421438 3 TGFB2, SYK 8 9 9 2
BMP4, CAV1, BMP2, RARG, PTGS2, 1.11111111 1352 3.11036174 0.63350180 0.00227351 0.59193 GO:0007584~response to nutrient 15 3.29E-04 RXRA, RELA, STAT1, PTEN, TGFB1, 466 140 1 8 1 1 5 7 VDR, CD44, IL1B, RARA, COL1A1
CDKN1B, CHD7, FGF9, DLX5, FOXG1, 0.81481481 1352 4.04215787 0.66617930 0.00247916 0.64683 GO:0048839~inner ear development 11 3.60E-04 SIX1, JAG2, TGFB3, FGF10, TBX1, 466 79 5 8 5 1 4 3 TGFB1
GO:0070169~positive regulation of 0.44444444 BMP4, P2RX7, BMP2, TGFB3, SMAD3, 1352 9.16738197 0.67269734 0.00251797 6 3.66E-04 466 19 0.65842 biomineral formation 4 TGFB1 8 4 5 6
GO:0046626~regulation of insulin 0.44444444 SOCS3, RELA, SOCS1, IL1B, PTPN1, 1352 9.16738197 0.67269734 0.00251797 6 3.66E-04 466 19 0.65842 receptor signaling pathway 4 IRS1 8 4 5 6
GO:0033081~regulation of T cell 1352 13.1954740 0.68158654 0.00257416 0.67459 5 0.37037037 3.75E-04 CDKN2A, ERBB2, IL2RG, ZEB1, IL7R 466 11 differentiation in the thymus 8 5 8 9 7
GO:0002726~positive regulation of T cell 0.29629629 1352 23.2240343 0.68931648 0.00262347 0.68903 4 3.83E-04 MAP3K7, TRAF2, MALT1, TRAF6 466 5 cytokine production 6 8 3 9 5 4
GO:0032331~negative regulation of 4 0.29629629 3.83E-04 PTHLH, BMP4, SOX9, GLI2 466 5 1352 23.2240343 0.68931648 0.00262347 0.68903 chondrocyte differentiation 6 8 3 9 5 4
GO:0052553~modulation by symbiont of 0.29629629 1352 23.2240343 0.68931648 0.00262347 0.68903 4 3.83E-04 TLR2, TLR3, TLR4, TLR7 466 5 host immune response 6 8 3 9 5 4
GO:0052556~positive regulation by 0.29629629 1352 23.2240343 0.68931648 0.00262347 0.68903 4 3.83E-04 TLR2, TLR3, TLR4, TLR7 466 5 symbiont of host immune response 6 8 3 9 5 4
GO:0052167~modulation by symbiont of 0.29629629 1352 23.2240343 0.68931648 0.00262347 0.68903 4 3.83E-04 TLR2, TLR3, TLR4, TLR7 466 5 host innate immunity 6 8 3 9 5 4
GO:0052306~modulation by organism of 0.29629629 1352 23.2240343 0.68931648 0.00262347 0.68903 innate immunity in other organism during 4 3.83E-04 TLR2, TLR3, TLR4, TLR7 466 5 6 8 3 9 5 4 symbiotic interaction
GO:0002282~microglial cell activation 0.29629629 1352 23.2240343 0.68931648 0.00262347 0.68903 4 3.83E-04 TLR2, TLR3, TLR4, TLR7 466 5 during immune response 6 8 3 9 5 4
GO:0052305~positive regulation by 0.29629629 1352 23.2240343 0.68931648 0.00262347 0.68903 organism of innate immunity in other 4 3.83E-04 TLR2, TLR3, TLR4, TLR7 466 5 6 8 3 9 5 4 organism during symbiotic interaction
GO:0052166~positive regulation by 0.29629629 1352 23.2240343 0.68931648 0.00262347 0.68903 4 3.83E-04 TLR2, TLR3, TLR4, TLR7 466 5 symbiont of host innate immunity 6 8 3 9 5 4
GO:0052555~positive regulation by 0.29629629 1352 23.2240343 0.68931648 0.00262347 0.68903 organism of immune response of other 4 3.83E-04 TLR2, TLR3, TLR4, TLR7 466 5 6 8 3 9 5 4 organism during symbiotic interaction
0.29629629 1352 23.2240343 0.68931648 0.00262347 0.68903 GO:0002347~response to tumor cell 4 3.83E-04 CRTAM, TP53, TP63, TP73 466 5 6 8 3 9 5 4
GO:0052552~modulation by organism of 0.29629629 1352 23.2240343 0.68931648 0.00262347 0.68903 immune response of other organism 4 3.83E-04 TLR2, TLR3, TLR4, TLR7 466 5 6 8 3 9 5 4 during symbiotic interaction
GO:0002831~regulation of response to 7 0.51851851 3.87E-04 MAVS, DDX58, PVR, CRTAM, PML, 466 29 1352 7.00725173 0.69266851 0.00264185 0.69540 biotic stimulus 9 CD226, CD28 8 9 9 9 6
0.51851851 IRF6, TP63, SFN, NGFR, COL1A1, EDA, 1352 7.00725173 0.69266851 0.00264185 0.69540 GO:0043588~skin development 7 3.87E-04 466 29 9 APC 8 9 9 9 6
IRS2, CAV1, TNF, STK11, STAT5B, GO:0019216~regulation of lipid 0.96296296 1352 3.36955855 0.75621897 0.00315270 0.83137 13 4.63E-04 NFKB1, RB1, IRS1, TGFB1, APOE, CD81, 466 112 metabolic process 3 8 3 5 4 8 IFNG, IL1B
GO:0030500~regulation of bone 0.51851851 BMP4, P2RX7, BMP2, TGFB3, SMAD3, 1352 6.77367668 0.76129554 0.00319250 0.84372 7 4.70E-04 466 30 mineralization 9 SOX9, TGFB1 8 1 7 3 1
0.44444444 IL6, CARD9, RELA, TICAM1, TLR7, 1352 8.70901287 0.76484276 0.00321864 0.85250 GO:0051607~defense response to virus 6 4.74E-04 466 20 4 TLR8 8 6 3 2 1
GO:0033619~membrane protein 0.44444444 P2RX7, RELA, ERAP1, NFKB1, NGFR, 1352 8.70901287 0.76484276 0.00321864 0.85250 6 4.74E-04 466 20 proteolysis 4 TRAF6 8 6 3 2 1
TNF, FGF9, TP53, TGFB3, PML, PAX6, GO:0033365~protein localization in 1.11111111 1352 2.98253865 0.00342027 0.90776 15 5.05E-04 NFKBIA, FGF10, GLI3, TGFB1, TGFB2, 466 146 0.78599647 organelle 1 8 6 7 3 CBLB, IFNG, PRL, SEC61G
GO:0030307~positive regulation of cell 0.59259259 EP300, TNFRSF12A, PTK2B, PRSS2, ILK, 1352 5.52953198 0.00347710 0.92484 8 5.15E-04 466 42 0.7921436 growth 3 SFN, IL2, TGFB2 8 4 7 4
GO:0050854~regulation of antigen 1352 12.0958512 0.81181106 0.00368855 0.98307 5 0.37037037 5.47E-04 BCL10, CBLB, MALT1, PAWR, TRAT1 466 12 receptor-mediated signaling pathway 8 2 8 4 6
GO:0035270~endocrine system 0.74074074 BMP4, IL6, CRKL, FOXA2, SIX1, PAX6, 1352 4.20725259 0.00378151 1.00999 10 5.63E-04 466 69 0.82026504 development 1 TBX1, CDH1, PBX1, GLI2 8 7 2 1
GO:0008637~apoptotic mitochondrial 0.51851851 CDKN2A, TP53, SMAD3, SFN, MYC, 1352 6.55517098 0.82191324 0.00379341 1.01538 7 5.66E-04 466 31 changes 9 IFI6, TP73 8 2 2 3 5
FGFR2, BMP4, FGFR1, BMP2, PTGS2, 1.25925925 1352 2.69677994 0.83016403 0.00388895 1.04315 GO:0040007~growth 17 5.81E-04 RXRA, TGFB3, FGF10, SMAD2, GLI2, 466 183 9 8 3 4 1 4 IL7R, GLI3, TGFB1, TGFB2, SMO, NOTCH1, FOXC1
NOG, ERBB2, PAX6, IL7R, SOX9, GLI2,
TGFB1, TGFB2, CUL3, IGF1R, PVRL1,
GO:0032989~cellular component 2.07407407 ILK, NFATC1, APC, EGFR, BMP2, EGR2, 1352 2.04745894 0.83383755 0.00392820 1.05595 28 5.88E-04 466 397 morphogenesis 4 RXRA, EFNB1, UBE2B, VASP, SMO, 8 6 7 6 2
P2RX7, NOTCH1, S100B, DLX5, FOXG1,
NGFR
0.44444444 P2RX7, IL2RA, STAT5B, FAS, FOXP3, 1352 8.29429797 0.84225306 0.00403290 1.08636 GO:0043029~T cell homeostasis 6 6.05E-04 466 21 4 TGFB1 8 7 6 3 4
GO:0045429~positive regulation of nitric 0.44444444 EGFR, TNF, TICAM1, IFNG, KLRK1, 1352 8.29429797 0.84225306 0.00403290 1.08636 6 6.05E-04 466 21 oxide biosynthetic process 4 IL1B 8 7 6 3 4
GO:0001836~release of cytochrome c 0.44444444 1352 8.29429797 0.84225306 0.00403290 1.08636 6 6.05E-04 TP53, SMAD3, SFN, MYC, IFI6, TP73 466 21 from mitochondria 4 8 7 6 3 4
BCL10, CRTAM, MYD88, CD8A, GO:0002449~lymphocyte mediated 0.74074074 1352 4.14714898 0.85204464 0.00416345 1.12384 10 6.26E-04 CD40LG, FAS, INPP5D, HLA-DMA, 466 70 immunity 1 8 8 1 9 7 TLR8, HLA-DRA
IRS2, THRA, RXRA, STAT5B, PRKDC, GO:0032870~cellular response to 1.03703703 1352 3.05579399 0.86736173 0.00439148 1.18773 14 6.62E-04 STAT1, UBE2B, IRS1, STAT3, FOS, 466 133 hormone stimulus 7 8 1 9 3 9 IGF1R, GH1, PTPN1, GHR
GO:0009880~embryonic pattern 0.51851851 MEOX2, EFNB1, SMAD5, FGF10, 1352 6.35032188 0.87291938 0.00447459 1.21275 7 6.76E-04 466 32 specification 9 SMAD2, ZBTB16, SMAD1 8 8 6 7 2
GO:0070167~regulation of biomineral 0.51851851 BMP4, P2RX7, BMP2, TGFB3, SMAD3, 1352 6.35032188 0.87291938 0.00447459 1.21275 7 6.76E-04 466 32 formation 9 SOX9, TGFB1 8 8 6 7 2
BCL10, IL6, CRTAM, MYD88, CD8A, GO:0002443~leukocyte mediated 0.81481481 1352 3.71314502 0.88676143 0.00471392 1.28011 11 7.14E-04 CD40LG, FAS, INPP5D, HLA-DMA, 466 86 immunity 5 8 4 5 7 4 TLR8, HLA-DRA GO:0060390~regulation of SMAD 0.29629629 1352 19.3533619 0.89758093 1.33873 4 7.47E-04 BMP4, SMAD4, TGFB3, TGFB1 466 6 0.00492007 protein nuclear translocation 6 8 5 2 4
GO:0019885~antigen processing and 0.29629629 1352 19.3533619 0.89758093 1.33873 presentation of endogenous peptide 4 7.47E-04 TAP2, ERAP1, ERAP2, TAPBP 466 6 0.00492007 6 8 5 2 4 antigen via MHC class I
GO:0052572~response to host immune 0.29629629 1352 19.3533619 0.89758093 1.33873 4 7.47E-04 TLR2, TLR3, TLR4, TLR7 466 6 0.00492007 response 6 8 5 2 4
0.29629629 1352 19.3533619 0.89758093 1.33873 GO:0007252~I-kappaB phosphorylation 4 7.47E-04 MAP3K7, ERC1, IKBKB, CHUK 466 6 0.00492007 6 8 5 2 4
GO:0052564~response to immune 0.29629629 1352 19.3533619 0.89758093 1.33873 response of other organism during 4 7.47E-04 TLR2, TLR3, TLR4, TLR7 466 6 0.00492007 6 8 5 2 4 symbiotic interaction
GO:0002483~antigen processing and 0.29629629 1352 19.3533619 0.89758093 1.33873 presentation of endogenous peptide 4 7.47E-04 TAP2, ERAP1, ERAP2, TAPBP 466 6 0.00492007 6 8 5 2 4 antigen
GO:0060391~positive regulation of 0.29629629 1352 19.3533619 0.89758093 1.33873 4 7.47E-04 BMP4, SMAD4, TGFB3, TGFB1 466 6 0.00492007 SMAD protein nuclear translocation 6 8 5 2 4
GO:0045410~positive regulation of 0.29629629 1352 19.3533619 0.89758093 1.33873 4 7.47E-04 IFNG, TLR1, IL1B, TRAF6 466 6 0.00492007 interleukin-6 biosynthetic process 6 8 5 2 4
GO:0045670~regulation of osteoclast 0.44444444 TNFSF11, TNF, TLR3, TLR4, INPP5D, 1352 7.91728443 0.00500523 1.36473 6 7.61E-04 466 22 0.90204442 differentiation 4 APC 8 2 1 3
GO:0045930~negative regulation of 0.44444444 EGFR, PML, SMAD3, FOXC1, RB1, 1352 7.91728443 0.00500523 1.36473 6 7.61E-04 466 22 0.90204442 mitotic cell cycle 4 TGFB1 8 2 1 3
GO:0008633~activation of pro-apoptotic 0.44444444 TRAF2, TNFRSF10B, RIPK1, SMAD3, 1352 7.91728443 0.00500523 1.36473 6 7.61E-04 466 22 0.90204442 gene products 4 FAS, MYC 8 2 1 3
GO:0045682~regulation of epidermis 6 0.44444444 7.61E-04 NOTCH1, TNF, TP63, KEAP1, NGFR, 466 22 1352 7.91728443 0.90204442 0.00500523 1.36473 development 4 TGFB2 8 2 1 3
GO:0051043~regulation of membrane 1352 11.1654011 0.90441426 0.00504698 1.37901 5 0.37037037 7.69E-04 TNF, APOE, IFNG, IL1B, IL10 466 13 protein ectodomain proteolysis 8 2 3 7 9
GO:0042326~negative regulation of 0.59259259 CDKN1C, CDKN1A, CAV1, CDKN1B, 1352 5.16089651 0.91093664 0.00518737 1.42023 8 7.93E-04 466 45 phosphorylation 3 CDKN2A, SOCS1, TGFB1, IL2 8 9 1 5 7
0.74074074 SMO, BMP2, MSX1, CHD7, HAND2, 1352 3.97671820 0.92612780 0.00557542 1.52921 GO:0003007~heart morphogenesis 10 8.54E-04 466 73 1 RXRA, TBX1, FOXC1, TAB1, TGFB2 8 8 2 7 8
GO:0045834~positive regulation of lipid 0.59259259 IRS2, TNF, APOE, IFNG, CD81, IL1B, 1352 5.04870311 0.93731377 0.00591309 1.62480 8 9.08E-04 466 46 metabolic process 3 IRS1, TGFB1 8 6 6 8 3
GO:0032652~regulation of interleukin-1 0.44444444 P2RX7, PANX1, SAA1, IFNG, PYCARD, 1352 7.57305467 0.94419346 0.00614740 1.69242 6 9.46E-04 466 23 production 4 SMAD3 8 4 6 4 1
0.44444444 SMO, EDNRB, EFNB1, KITLG, TBX1, 1352 7.57305467 0.94419346 0.00614740 1.69242 GO:0001755~neural crest cell migration 6 9.46E-04 466 23 4 PAX3 8 4 6 4 1
GO:0045785~positive regulation of cell 0.66666666 TNF, SAA1, ERBB2, PRSS2, ILK, 1352 4.35450643 0.94923978 0.00633516 1.74751 9 9.77E-04 466 60 adhesion 7 SMAD3, IL1B, TGFB2, APC 8 8 7 2 6
IRAK1, BCL10, CAV1, TP53, TP63,
1.18518518 CDH1, MALT1, IRS1, TRIM21, 1352 2.66942923 0.95089598 0.00639185 1.76679 GO:0051259~protein oligomerization 16 9.88E-04 466 174 5 TNFRSF1A, IGF1R, P2RX7, NOD1, 8 4 5 6 1
TNFSF11, ILK, FAS
GO:0033135~regulation of 0.00104815 1352 10.3678724 0.95917886 0.00676798 1.87407 5 0.37037037 CAV1, IL6, IFNG, TGFB1, AXIN1 466 14 peptidyl-serine phosphorylation 7 8 7 3 1 1
GO:0050716~positive regulation of 0.00104815 1352 10.3678724 0.95917886 0.00676798 1.87407 5 0.37037037 P2RX7, PANX1, SAA1, IFNG, PYCARD 466 14 interleukin-1 secretion 7 8 7 3 1 1
GO:0010862~positive regulation of 0.00104815 1352 10.3678724 0.95917886 0.00676798 1.87407 pathway-restricted SMAD protein 5 0.37037037 BMP4, BMP2, SMAD4, TGFB3, TGFB1 466 14 7 8 7 3 1 1 phosphorylation GO:0031640~killing of cells of another 0.00104815 DEFA1B, DEFA5, DEFA4, DEFA3, 1352 10.3678724 0.95917886 0.00676798 1.87407 5 0.37037037 466 14 organism 7 DEFA1, S100A12 8 7 3 1 1
GO:0032731~positive regulation of 0.00104815 1352 10.3678724 0.95917886 0.00676798 1.87407 5 0.37037037 P2RX7, PANX1, IFNG, PYCARD, SMAD3 466 14 interleukin-1 beta production 7 8 7 3 1 1
EGFR, EGR2, EFNB1, RXRA, ERBB2,
GO:0048812~neuron projection 1.33333333 0.00110609 PAX6, GLI2, VASP, SMO, IGF1R, 1352 2.45324306 0.96579767 0.00712589 1.97669 18 466 213 morphogenesis 3 7 NOTCH1, PVRL1, S100B, DLX5, ILK, 8 4 2 1 1
FOXG1, NGFR, APC
VCAM1, CD40LG, TP53, PRKDC, 0.74074074 0.00114449 1352 3.81974248 0.96958137 0.00735694 GO:0042113~B cell activation 10 MALT1, CD40, IL7R, ICOSLG, IL10, 466 76 2.04464 1 2 8 9 3 8 BLNK
0.44444444 0.00116124 CRTAM, DEFA1B, DEFA5, DEFA4, 1352 0.97109867 0.00744863 2.07428 GO:0001906~cell killing 6 466 24 7.25751073 4 9 DEFA3, DEFA1, S100A12 8 6 5 1
GO:0045936~negative regulation of 0.59259259 0.00117701 CDKN1C, CDKN1A, CAV1, CDKN1B, 1352 4.83834048 0.97245701 8 466 48 0.0075336 2.10216 phosphate metabolic process 3 4 CDKN2A, SOCS1, TGFB1, IL2 8 6 8
GO:0010563~negative regulation of 0.59259259 0.00117701 CDKN1C, CDKN1A, CAV1, CDKN1B, 1352 4.83834048 0.97245701 8 466 48 0.0075336 2.10216 phosphorus metabolic process 3 4 CDKN2A, SOCS1, TGFB1, IL2 8 6 8
GO:0032582~negative regulation of 0.59259259 0.00117701 CDKN1C, CIITA, VDR, BMP2, CDKN1B, 1352 4.83834048 0.97245701 8 466 48 0.0075336 2.10216 gene-specific transcription 3 4 RXRA, SMAD3, NFKB1 8 6 8
GO:0048706~embryonic skeletal system 0.74074074 0.00125743 NOG, FGF9, SIX1, TGFB3, TFAP2A, 1352 3.77013544 0.97845477 0.00802977 2.24426 10 466 77 development 1 9 TBX1, PBX1, ZEB1, COL1A1, GLI3 8 4 6 5 5
GO:0045416~positive regulation of 0.29629629 0.00127364 1352 16.5885959 0.97949485 0.00811590 2.27286 4 BCL10, TLR4, TLR7, TLR8 466 7 interleukin-8 biosynthetic process 6 1 8 5 9 1 9
0.29629629 0.00127364 1352 16.5885959 0.97949485 0.00811590 2.27286 GO:0001774~microglial cell activation 4 TLR2, TLR3, TLR4, TLR7 466 7 6 1 8 5 9 1 9
GO:0033160~positive regulation of 4 0.29629629 0.00127364 BMP4, SMAD4, TGFB3, TGFB1 466 7 1352 16.5885959 0.97949485 0.00811590 2.27286 protein import into nucleus, translocation 6 1 8 5 9 1 9
0.29629629 0.00127364 1352 16.5885959 0.97949485 0.00811590 2.27286 GO:0048103~somatic stem cell division 4 NOTCH1, CDKN2A, KIT, TGFB2 466 7 6 1 8 5 9 1 9
GO:0045579~positive regulation of B cell 0.29629629 0.00127364 1352 16.5885959 0.97949485 0.00811590 2.27286 4 STAT5B, IL2RG, INPP5D, SYK 466 7 differentiation 6 1 8 5 9 1 9
GO:0046634~regulation of alpha-beta T 0.51851851 0.00129402 BTLA, CBLB, RIPK2, RARA, IL2RG, 1352 5.64473056 0.98073217 0.00822813 2.30883 7 466 36 cell activation 9 1 IRF4, SYK 8 7 6 5 8
GO:0031348~negative regulation of 0.51851851 0.00129402 IRAK3, TNFRSF1B, IL2RA, SAA1, APOE, 1352 5.64473056 0.98073217 0.00822813 2.30883 7 466 36 defense response 9 1 IL10, IL2 8 7 6 5 8
GO:0032677~regulation of interleukin-8 0.00139077 1352 9.67668097 0.98566150 0.00882266 2.47942 5 0.37037037 BCL10, TLR4, LBP, TLR7, TLR8 466 15 production 2 8 3 5 1 7
GO:0050704~regulation of interleukin-1 0.00139077 1352 9.67668097 0.98566150 0.00882266 2.47942 5 0.37037037 P2RX7, PANX1, SAA1, IFNG, PYCARD 466 15 secretion 2 8 3 5 1 7
GO:0002702~positive regulation of 0.00139077 MAP3K7, TRAF2, BCL10, MALT1, 1352 9.67668097 0.98566150 0.00882266 2.47942 production of molecular mediator of 5 0.37037037 466 15 2 TRAF6 8 3 5 1 7 immune response
CAV1, IL7, TP53, NFKB1, RB1, SFN,
GO:0043086~negative regulation of 1.55555555 0.00145728 TP73, TGFB2, CDKN1C, EDNRB, IRAK3, 1352 2.20083357 0.98829764 0.00922379 2.59653 21 466 277 catalytic activity 6 6 CDKN1A, CDKN2A, CDKN1B, APOE, 8 9 4 1 9
ILK, CCR2, IL1B, NQO1, IFI6, APC
0.66666666 0.00149939 CAV1, TNF, NFKBIE, APOE, NFKBIB, 1352 4.08234978 0.98971018 0.00946963 2.67061 GO:0051235~maintenance of location 9 466 64 7 9 PML, NFKBIA, IL1B, IL10 8 5 1 9 9
0.51851851 0.00150036 SMO, EDNRB, EFNB1, LRP6, KITLG, 1352 5.49217028 0.98974061 0.00945617 2.67232 GO:0001667~ameboidal cell migration 7 466 37 9 9 TBX1, PAX3 8 2 1 2 4
GO:0048634~regulation of muscle 0.59259259 0.00169413 BMP4, NOG, NOTCH1, FGF9, ILK, 1352 4.55373222 0.99432389 0.01064990 3.01248 8 466 51 development 3 4 SMAD3, NGFR, TGFB1 8 3 4 2 1 GO:0001818~negative regulation of 0.51851851 0.00173084 IRAK3, TNF, RARA, NFKB1, LBP, 1352 5.34763948 0.99492608 0.01085724 3.07679 7 466 38 cytokine production 9 2 FOXP3, IL10 8 5 1 5 6
0.00180443 1352 9.07188841 0.99594775 0.01129344 3.20560 GO:0033280~response to vitamin D 5 0.37037037 VDR, PTGS2, RXRA, IL1B, TGFB1 466 16 1 8 2 6 5 7
GO:0045954~positive regulation of 0.00180443 1352 9.07188841 0.99594775 0.01129344 3.20560 5 0.37037037 PVR, CRTAM, STAT5B, KLRK1, CD226 466 16 natural killer cell mediated cytotoxicity 1 8 2 6 5 7
GO:0060350~endochondral bone 0.00180443 1352 9.07188841 0.99594775 0.01129344 3.20560 5 0.37037037 PTHLH, COL1A1, SOX9, RUNX2, GHR 466 16 morphogenesis 1 8 2 6 5 7
GO:0002717~positive regulation of 0.00180443 1352 9.07188841 0.99594775 0.01129344 3.20560 5 0.37037037 PVR, CRTAM, STAT5B, KLRK1, CD226 466 16 natural killer cell mediated immunity 1 8 2 6 5 7
GO:0045577~regulation of B cell 0.00180443 1352 9.07188841 0.99594775 0.01129344 3.20560 5 0.37037037 CARD11, STAT5B, IL2RG, INPP5D, SYK 466 16 differentiation 1 8 2 6 5 7
0.66666666 0.00183297 NOG, CHD7, FGF9, DLX5, FOXG1, SIX1, 1352 3.95864221 0.99628623 0.01144777 3.25553 GO:0042471~ear morphogenesis 9 466 66 7 7 FGF10, TBX1, MYC 8 6 5 5 1
TNF, FGF9, TP53, TGFB3, PML, FGF10, 0.96296296 0.00185038 1352 2.88084395 0.99647858 0.01153235 3.28595 GO:0017038~protein import 13 NFKBIA, GLI3, TGFB1, TGFB2, CBLB, 466 131 3 2 8 4 4 5 8 IFNG, PRL
CDKN2A, TNF, CUL7, CAMK2D, PML, GO:0010564~regulation of cell cycle 0.88888888 0.00187066 1352 3.05579399 0.99669021 0.01163439 3.32140 12 HECTD3, IL1B, RB1, TGFB1, IL1A, 466 114 process 9 5 8 1 6 8 7 CD28, APC
EGFR, TXNIP, CAV1, PTGS2, RXRA,
GO:0010035~response to inorganic 1.25925925 0.00193450 RELA, STAT1, PTEN, FOS, P2RX7, 1352 2.40736941 0.99727680 0.01200496 3.43289 17 466 205 substance 9 3 CDKN1A, EP300, PTK2B, NEDD4, APOE, 8 3 3 3 2
NEDD4L, COL1A1
GO:0002902~regulation of B cell 0.29629629 0.00198597 1352 14.5150214 0.99767316 0.01229772 3.52269 4 BCL10, MYC, IL10, IL2 466 8 apoptosis 6 5 8 6 2 7 3 GO:0060396~growth hormone receptor 0.29629629 0.00198597 1352 14.5150214 0.99767316 0.01229772 3.52269 4 GH1, STAT5B, STAT3, GHR 466 8 signaling pathway 6 5 8 6 2 7 3
GO:0019883~antigen processing and 0.29629629 0.00198597 1352 14.5150214 0.99767316 0.01229772 3.52269 4 TAP2, ERAP1, ERAP2, TAPBP 466 8 presentation of endogenous antigen 6 5 8 6 2 7 3
GO:0007184~SMAD protein nuclear 0.29629629 0.00198597 1352 14.5150214 0.99767316 0.01229772 3.52269 4 PML, TGFB3, TGFB1, TGFB2 466 8 translocation 6 5 8 6 2 7 3
GO:0017015~regulation of transforming 0.51851851 0.00198720 CDKN1C, SMAD4, TGFB3, SMAD3, 1352 5.21052052 0.99768189 0.01228039 3.52483 growth factor beta receptor signaling 7 466 39 9 5 SMAD2, ZEB1, TGFB1 8 4 4 8 8 pathway
0.66666666 0.00202037 EGFR, BMP4, BMP2, ERBB2, VEGFA, 1352 3.89955800 0.99790535 0.01245907 3.58266 GO:0042698~ovulation cycle 9 466 67 7 3 STAT5B, TGFB3, FOXC1, TGFB2 8 4 4 4 3
NOG, FOXA2, TNFRSF12A, PAX6, GO:0045664~regulation of neuron 0.96296296 0.00210388 1352 2.83752299 0.99837720 0.01294510 3.72810 13 SMAD1, GLI2, NOTCH1, APOE, SIX1, 466 133 differentiation 3 3 8 2 1 2 7 FOXG1, ILK, PBX1, NGFR
GO:0032869~cellular response to insulin 0.66666666 0.00222252 IGF1R, IRS2, RXRA, PRKDC, PTPN1, 1352 3.84221156 0.99887080 0.01364342 3.93438 9 466 68 stimulus 7 8 STAT1, UBE2B, IRS1, GHR 8 3 8 8 6
GO:0051341~regulation of 0.51851851 0.00227126 EGFR, VDR, TNF, APOE, IFNG, IL1B, 1352 5.08025751 0.99902709 4.01899 7 466 40 0.01391287 oxidoreductase activity 9 2 NFKB1 8 1 8 6
0.51851851 0.00227126 IL6, SAA1, STAT5B, IL1B, LBP, STAT3, 1352 5.08025751 0.99902709 4.01899 GO:0006953~acute-phase response 7 466 40 0.01391287 9 2 IL1A 8 1 8 6
GO:0002053~positive regulation of 0.00229617 1352 8.53824791 0.99909845 4.06222 5 0.37037037 IRS2, FGF9, VEGFA, TP63, IRS1 466 17 0.01403644 mesenchymal cell proliferation 9 8 7 2 8
GO:0002715~regulation of natural killer 0.00229617 1352 8.53824791 0.99909845 4.06222 5 0.37037037 PVR, CRTAM, STAT5B, KLRK1, CD226 466 17 0.01403644 cell mediated immunity 9 8 7 2 8
GO:0042269~regulation of natural killer 0.00229617 1352 8.53824791 0.99909845 4.06222 5 0.37037037 PVR, CRTAM, STAT5B, KLRK1, CD226 466 17 0.01403644 cell mediated cytotoxicity 9 8 7 2 8 GO:0060393~regulation of 0.00229617 1352 8.53824791 0.99909845 4.06222 pathway-restricted SMAD protein 5 0.37037037 BMP4, BMP2, SMAD4, TGFB3, TGFB1 466 17 0.01403644 9 8 7 2 8 phosphorylation
GO:0000079~regulation of 0.59259259 0.00237256 EGFR, CDKN1C, CDKN1A, CDKN1B, 1352 4.30074709 0.99928621 0.01447157 4.19464 8 466 54 cyclin-dependent protein kinase activity 3 6 CDKN2A, SFN, PTEN, APC 8 9 1 5 9
GO:0008629~induction of apoptosis by 0.59259259 0.00237256 CUL3, CDKN1A, PML, TP53, TP63, SFN, 1352 4.30074709 0.99928621 0.01447157 4.19464 8 466 54 intracellular signals 3 6 MYC, TP73 8 9 1 5 9
GO:0045740~positive regulation of DNA 0.44444444 0.00239805 1352 6.22072348 0.99933972 0.01459695 4.23880 6 IGF1R, CSF2, IL3, TGFB3, KITLG, GLI2 466 28 replication 4 8 8 3 9 5 3
IL6, NOG, FOXA2, ERBB2, TGFB3,
1.18518518 0.00249237 SMAD3, FGF10, CD40, SMAD1, TGFB1, 1352 2.43183605 0.99950513 0.01513721 4.40199 GO:0042060~wound healing 16 466 191 5 2 TGFB2, NOTCH1, CD44, CD40LG, SAA1, 8 6 4 7 3
IL1B
TRAF1, TRAF2, CAV1, PML, TP63,
CDH1, HLA-DMA, TGFB1, TAPBP,
IGF1R, TNFRSF1A, NOD1, PTK2B,
GO:0065003~macromolecular complex 2.81481481 0.00266138 APOE, TAP2, IL1RAP, ILK, FAS, MYC, 1352 1.65885959 0.99970485 4.69377 38 466 665 0.01612467 assembly 5 4 SYK, APC, BCL10, IRAK1, MLL, 8 5 5 5
CREBBP, SMAD4, TP53, SMAD3,
MALT1, SMAD2, SMAD1, CD40, IRS1,
TRIM21, P2RX7, TNFSF11, PRLR, IRF7
GO:0008543~fibroblast growth factor 0.44444444 FGFR2, FGFR1, FGF8, FGF9, CTGF, 1352 6.00621577 0.99981666 0.01702745 4.96182 6 0.00281708 466 29 receptor signaling pathway 4 FGF10 8 6 9 3 1
GO:0050921~positive regulation of 0.44444444 IL6, VEGFA, SMAD3, FGF10, AGER, 1352 6.00621577 0.99981666 0.01702745 4.96182 6 0.00281708 466 29 chemotaxis 4 TGFB1 8 6 9 3 1
GO:0006913~nucleocytoplasmic 14 1.03703703 0.00283479 TNF, FGF9, TP53, TGFB3, PML, NFKBIA, 466 156 1352 2.60526026 0.99982633 0.01709989 4.99226 transport 7 1 FGF10, MALT1, GLI3, TGFB1, TGFB2, 8 2 6 7 8
CBLB, IFNG, PRL
GO:0042345~regulation of NF-kappaB 0.00287292 1352 8.06390081 0.99984545 0.01729411 5.05779 5 0.37037037 TNF, NFKBIB, NFKBIA, EDA, IL10 466 18 import into nucleus 7 8 1 7 6 5
0.00287292 1352 8.06390081 0.99984545 0.01729411 5.05779 GO:0030593~neutrophil chemotaxis 5 0.37037037 SAA1, IFNG, IL1B, TGFB2, SYK 466 18 7 8 1 7 6 5
GO:0035116~embryonic hindlimb 0.00287292 1352 8.06390081 0.99984545 0.01729411 5.05779 5 0.37037037 NOTCH1, RARG, CHD7, LRP6, ZBTB16 466 18 morphogenesis 7 8 1 7 6 5
GO:0045414~regulation of interleukin-8 0.29629629 0.00290329 1352 0.99985916 0.01744122 5.10994 4 BCL10, TLR4, TLR7, TLR8 466 9 12.9022413 biosynthetic process 6 8 8 7 4 9
GO:0060416~response to growth 0.29629629 0.00290329 1352 0.99985916 0.01744122 5.10994 4 GH1, STAT5B, STAT3, GHR 466 9 12.9022413 hormone stimulus 6 8 8 7 4 9
GO:0033158~regulation of protein import 0.29629629 0.00290329 1352 0.99985916 0.01744122 5.10994 4 BMP4, SMAD4, TGFB3, TGFB1 466 9 12.9022413 into nucleus, translocation 6 8 8 7 4 9
GO:0051044~positive regulation of 0.29629629 0.00290329 1352 0.99985916 0.01744122 5.10994 4 TNF, APOE, IFNG, IL1B 466 9 12.9022413 membrane protein ectodomain proteolysis 6 8 8 7 4 9
GO:0001914~regulation of T cell 0.29629629 0.00290329 1352 0.99985916 0.01744122 5.10994 4 PVR, P2RX7, TAP2, IL7R 466 9 12.9022413 mediated cytotoxicity 6 8 8 7 4 9
0.59259259 0.00292962 BCL10, MYD88, CD40LG, FAS, INPP5D, 1352 4.14714898 0.99987006 0.01756369 5.15514 GO:0019724~B cell mediated immunity 8 466 56 3 8 HLA-DMA, TLR8, HLA-DRA 8 8 6 1 2
GO:0031647~regulation of protein 0.51851851 CDKN2A, PML, IFI30, PRKDC, SOX4, 1352 4.83834048 0.01753054 5.15550 7 0.00292984 466 42 0.99987015 stability 9 UBE2B, PTEN 8 6 3 5
WNT5A, PANX1, FGF9, TOLLIP,
2.59259259 0.00296736 CAMK2G, IL18, FGF10, TP63, GLI2, 1352 0.01771867 5.21987 GO:0007267~cell-cell signaling 35 466 600 1.69341917 0.99988423 3 1 IL10, TGFB2, LNPEP, TNFRSF11A, 8 2 2
PVRL1, APOE, IL1B, RAPGEF4, NQO1, SYK, BMP4, IL3, BMP2, IL6, IL7, EFNB1,
SMAD2, PARK2, ESR2, PTHLH, SMO,
LILRB2, P2RX7, TXN, SIX1, IL2
TNF, FGF9, TP53, TGFB3, PML, NFKBIA, 1.03703703 1352 2.57228228 0.99993703 0.01886101 GO:0051169~nuclear transport 14 0.00316642 FGF10, MALT1, GLI3, TGFB1, TGFB2, 466 158 5.56066 7 8 4 3 1 CBLB, IFNG, PRL
GO:0045787~positive regulation of cell 0.59259259 0.00324316 EGFR, TNF, FOXG1, STAT5B, IL1B, 1352 4.07439198 0.99995021 0.01927686 5.69173 8 466 57 cycle 3 5 IL1A, CD28, TGFB2 8 9 2 3 8
GO:0045638~negative regulation of 0.44444444 0.00328658 STAT5B, NFKBIA, TLR3, TLR4, ZBTB16, 1352 5.80600858 0.99995640 0.01949488 5.76581 6 466 30 myeloid cell differentiation 4 1 INPP5D 8 4 6 2 5
CAV1, MLL, TNF, PML, SMAD3, FOXP3, GO:0033043~regulation of organelle 1.25925925 0.00342911 1352 2.27424299 0.99997181 0.02029375 6.00862 17 UBE2N, P2RX7, CDKN1B, CUL7, ILK, 466 217 organization 9 7 8 4 7 7 5 IL1B, HECTD3, MYC, IL1A, APC, CD28
0.22222222 1352 29.0300429 0.99997407 0.02041464 6.05513 GO:0032808~lacrimal gland development 3 0.00345646 PAX6, FGF10, FOXC1 466 3 2 8 2 9 9 7
GO:0033083~regulation of immature T 0.22222222 1352 29.0300429 0.99997407 0.02041464 6.05513 3 0.00345646 CDKN2A, ERBB2, RIPK2 466 3 cell proliferation 2 8 2 9 9 7
GO:0060559~positive regulation of 0.22222222 1352 29.0300429 0.99997407 0.02041464 6.05513 3 0.00345646 TNF, IFNG, IL1B 466 3 calcidiol 1-monooxygenase activity 2 8 2 9 9 7
GO:0042976~activation of Janus kinase 0.22222222 1352 29.0300429 0.99997407 0.02041464 6.05513 3 0.00345646 PRLR, PTK2B, GHR 466 3 activity 2 8 2 9 9 7
GO:0021910~smoothened signaling 0.22222222 1352 29.0300429 0.99997407 0.02041464 6.05513 pathway involved in ventral spinal cord 3 0.00345646 SMO, GLI2, GLI3 466 3 2 8 2 9 9 7 patterning
0.00354140 1352 7.63948497 0.99998001 0.02087164 6.19949 GO:0045058~T cell selection 5 0.37037037 CARD11, JAG2, FAS, HLA-DMA, SYK 466 19 9 8 9 4 1 9 GO:0048483~autonomic nervous system 0.00354140 1352 7.63948497 0.99998001 0.02087164 6.19949 5 0.37037037 SMO, EDNRB, EGR2, ERBB2, TP63 466 19 development 9 8 9 4 1 9
EGFR, TNF, TP53, PML, SMAD3, STAT1, GO:0051345~positive regulation of 1.11111111 0.00355329 1352 2.43268516 0.99998072 0.02090078 6.21968 15 NLRP1, EDNRB, CDKN2A, TNFRSF10B, 466 179 hydrolase activity 1 8 8 1 8 4 7 NOD1, PTK2B, IFNG, PYCARD, MYC
GO:0016331~morphogenesis of 0.59259259 0.00358167 MAP3K7, BCL10, JAG2, TFAP2A, PAX3, 1352 4.00414385 0.99998233 0.02102574 6.26785 8 466 58 embryonic epithelium 3 5 TRAF6, GLI2, VASP 8 1 1 8 2
0.51851851 0.00372160 BMP4, NOG, BMP2, MSX1, SMAD5, 1352 4.61841591 0.99998848 0.02179780 6.50502 GO:0030509~BMP signaling pathway 7 466 44 9 4 SMAD4, SMAD1 8 9 7 6 8
0.66666666 0.00379070 BMP4, HCK, VEGFA, SMAD3, TP63, 1352 3.53068089 0.99999068 0.02215631 6.62194 GO:0007498~mesoderm development 9 466 74 7 6 TBX1, SMAD2, FOXC1, SMAD1 8 5 3 8 3
GO:0043900~regulation of 0.44444444 0.00380985 MAVS, DDX58, P2RX7, IFNG, PML, 1352 5.61871798 0.99999121 0.02222467 6.65431 6 466 31 multi-organism process 4 2 CD28 8 4 3 8 4
0.44444444 0.00380985 IL6, VEGFA, SMAD3, FGF10, AGER, 1352 5.61871798 0.99999121 0.02222467 6.65431 GO:0050920~regulation of chemotaxis 6 466 31 4 2 TGFB1 8 4 3 8 4
GO:0050728~negative regulation of 0.44444444 0.00380985 TNFRSF1B, IL2RA, SAA1, APOE, IL10, 1352 5.61871798 0.99999121 0.02222467 6.65431 6 466 31 inflammatory response 4 2 IL2 8 4 3 8 4
EGFR, CAV1, UBE2A, SOCS3, RELA,
1.18518518 0.00385882 TP53, PML, PRKDC, KIT, UBE2B, 1352 2.32240343 0.99999243 6.73706 GO:0009314~response to radiation 16 466 200 0.02246479 5 5 TGFB1, FOS, CDKN1A, TNFSF11, 8 3 7 2
NEDD4, MYC
0.59259259 0.00394640 EGFR, CDKN1A, UBE2A, NEDD4, RELA, 1352 3.93627700 0.99999421 0.02292608 6.88487 GO:0009411~response to UV 8 466 59 3 5 PML, TP53, UBE2B 8 6 6 7 1
GO:0042534~regulation of tumor 0.29629629 0.00404240 1352 11.6120171 0.99999568 7.04664 4 CARD9, TLR1, TLR4, IL10 466 10 0.02343379 necrosis factor biosynthetic process 6 8 8 7 9 2
GO:0043550~regulation of lipid kinase 4 0.29629629 0.00404240 CD81, RB1, IRS1, TGFB1 466 10 1352 11.6120171 0.99999568 0.02343379 7.04664 activity 6 8 8 7 9 2
GO:0030522~intracellular 0.66666666 0.00411916 VDR, RARG, NEDD4, RXRA, PML, 1352 0.99999659 0.02382909 7.17578 9 466 75 3.48360515 receptor-mediated signaling pathway 7 1 RARA, RB1, PIAS1, ESR2 8 2 7 5
GO:0032651~regulation of interleukin-1 0.00430814 1352 0.02486391 7.49303 5 0.37037037 P2RX7, PANX1, IFNG, PYCARD, SMAD3 466 20 7.25751073 0.99999809 beta production 2 8 1 6
GO:0042036~negative regulation of 0.00430814 1352 0.02486391 7.49303 5 0.37037037 IL6, ASB1, INPP5D, FOXP3, IL10 466 20 7.25751073 0.99999809 cytokine biosynthetic process 2 8 1 6
GO:0045685~regulation of glial cell 0.00430814 1352 0.02486391 7.49303 5 0.37037037 BMP4, NOG, NOTCH1, BMP2, RELA 466 20 7.25751073 0.99999809 differentiation 2 8 1 6
EGFR, TXNIP, PTGS2, RELA, PTGS1, 1.03703703 0.00435526 1352 2.47817439 0.99999834 0.02508564 GO:0006979~response to oxidative stress 14 PML, TLR4, STAT1, FOS, EP300, PTK2B, 466 164 7.57198 7 3 8 5 6 7 APOE, COL1A1, NQO1
0.44444444 0.00439016 EGFR, TNF, PTK2B, TP53, TLR3, 1352 5.44313304 0.99999851 0.02523702 7.63041 GO:0006970~response to osmotic stress 6 466 32 4 9 ICOSLG 8 7 4 3 8
0.44444444 0.00439016 CHD7, MEOX2, SMAD4, TGFB3, TBX1, 1352 5.44313304 0.99999851 0.02523702 7.63041 GO:0060021~palate development 6 466 32 4 9 SMAD2 8 7 4 3 8
0.51851851 0.00466190 IL6, VEGFA, SMAD3, FGF10, ESR2, 1352 4.41761522 0.99999935 0.02673137 GO:0050795~regulation of behavior 7 466 46 8.08416 9 3 AGER, TGFB1 8 7 4 4
EGFR, EGR2, EFNB1, RXRA, ERBB2,
GO:0048858~cell projection 1.33333333 0.00480882 PAX6, GLI2, VASP, SMO, IGF1R, 1352 0.99999958 0.02751255 8.32861 18 466 245 2.13281948 morphogenesis 3 9 NOTCH1, PVRL1, S100B, DLX5, ILK, 8 8 6 8
FOXG1, NGFR, APC
CAV1, PTGS2, SMAD5, PTGS1, STAT1,
1.11111111 0.00499624 EDNRB, CHD7, ATG5, MEOX2, APOE, 1352 2.34113249 0.99999976 0.02851865 8.63955 GO:0003013~circulatory system process 15 466 186 1 3 VEGFA, CAMK2D, ERAP1, ERAP2, 8 3 8 5 2
FOXC1 CAV1, PTGS2, SMAD5, PTGS1, STAT1,
1.11111111 0.00499624 EDNRB, CHD7, ATG5, MEOX2, APOE, 1352 2.34113249 0.99999976 0.02851865 8.63955 GO:0008015~blood circulation 15 466 186 1 3 VEGFA, CAMK2D, ERAP1, ERAP2, 8 3 8 5 2
FOXC1
0.00517939 1352 6.91191498 0.99999986 0.02949614 8.94245 GO:0021532~neural tube patterning 5 0.37037037 BMP4, SMO, FOXA2, PAX6, GLI2 466 21 6 8 1 8 6 2
GO:0048546~digestive tract 0.00517939 1352 6.91191498 0.99999986 0.02949614 8.94245 5 0.37037037 NOTCH1, TP63, GLI2, GLI3, TP73 466 21 morphogenesis 6 8 1 8 6 2
GO:0045884~regulation of survival gene 0.00517939 1352 6.91191498 0.99999986 0.02949614 8.94245 5 0.37037037 CSF2, IL3, STAT5B, ESR2, MYC 466 21 product expression 6 8 1 8 6 2
GO:0032845~negative regulation of 0.00517939 1352 6.91191498 0.99999986 0.02949614 8.94245 5 0.37037037 P2RX7, VEGFA, INPP5D, IFI6, TGFB1 466 21 homeostatic process 6 8 1 8 6 2
GO:0055123~digestive system 0.00517939 1352 6.91191498 0.99999986 0.02949614 8.94245 5 0.37037037 NOTCH1, TP63, GLI2, GLI3, TP73 466 21 development 6 8 1 8 6 2
0.00517939 1352 6.91191498 0.99999986 0.02949614 8.94245 GO:0014013~regulation of gliogenesis 5 0.37037037 BMP4, NOG, NOTCH1, BMP2, RELA 466 21 6 8 1 8 6 2
GO:0031346~positive regulation of cell 0.51851851 TNFRSF12A, ILK, TGFB3, SMAD1, KIT, 1352 4.32362341 0.99999987 0.02951545 8.96425 7 0.0051926 466 47 projection organization 9 NGFR, APC 8 3 3 1 3
GO:0006275~regulation of DNA 0.59259259 0.00521061 IGF1R, CSF2, IL3, TGFB3, TP53, KITLG, 1352 3.74581198 0.02956162 8.99398 8 466 62 0.99999988 replication 3 2 GLI2, TGFB1 8 9 5 4
GO:0045078~positive regulation of 0.29629629 0.00541763 1352 10.5563792 0.99999993 0.03066418 4 TLR3, TLR7, TLR8, TLR9 466 11 9.33503 interferon-gamma biosynthetic process 6 2 8 4 6 6
GO:0042994~cytoplasmic sequestering of 0.29629629 0.00541763 1352 10.5563792 0.99999993 0.03066418 4 NFKBIE, NFKBIB, NFKBIA, IL10 466 11 9.33503 transcription factor 6 2 8 4 6 6
GO:0032729~positive regulation of 0.29629629 0.00541763 1352 10.5563792 0.99999993 0.03066418 4 IL18, KLRK1, RIPK2, IFNAR1 466 11 9.33503 interferon-gamma production 6 2 8 4 6 6 GO:0045736~negative regulation of 0.29629629 0.00541763 1352 10.5563792 0.99999993 0.03066418 4 CDKN1A, CDKN1B, CDKN2A, APC 466 11 9.33503 cyclin-dependent protein kinase activity 6 2 8 4 6 6
GO:0031293~membrane protein 0.29629629 0.00541763 1352 10.5563792 0.99999993 0.03066418 4 RELA, NFKB1, NGFR, TRAF6 466 11 9.33503 intracellular domain proteolysis 6 2 8 4 6 6
0.29629629 0.00541763 1352 10.5563792 0.99999993 0.03066418 GO:0043616~keratinocyte proliferation 4 IRF6, TP63, FGF10, SFN 466 11 9.33503 6 2 8 4 6 6
GO:0032965~regulation of collagen 0.29629629 0.00541763 1352 10.5563792 0.99999993 0.03066418 4 CIITA, IL6, TGFB3, TGFB1 466 11 9.33503 biosynthetic process 6 2 8 4 6 6
TNFRSF12A, APOE, ILK, VEGFA, GO:0022604~regulation of cell 0.88888888 0.00549227 1352 2.65924057 0.99999994 0.03102379 9.45770 12 SMAD4, TGFB3, SMAD3, SMAD2, 466 131 morphogenesis 9 6 8 3 9 1 3 SMAD1, NGFR, TGFB1, TGFB2
0.59259259 0.00569297 TNFRSF1A, IL6, ERBB2, PML, ERAP1, 1352 3.68635465 0.99999997 0.03208300 9.78675 GO:0045765~regulation of angiogenesis 8 466 63 3 2 IL1B, TNFSF12, IL1A 8 6 3 8 9
GO:0048520~positive regulation of 0.44444444 0.00573490 IL6, VEGFA, SMAD3, FGF10, AGER, 1352 0.99999997 9.85537 6 466 34 5.12294875 0.03225673 behavior 4 8 TGFB1 8 6 3
GO:0051651~maintenance of location in 0.51851851 0.00576625 CAV1, NFKBIE, APOE, NFKBIB, PML, 1352 4.23354792 0.99999997 0.03237114 9.90663 7 466 48 cell 9 5 NFKBIA, IL10 8 6 8 6 1
0.51851851 0.00576625 VCAM1, CD40LG, TP53, PRKDC, 1352 4.23354792 0.99999997 0.03237114 9.90663 GO:0030183~B cell differentiation 7 466 48 9 5 MALT1, IL10, BLNK 8 6 8 6 1
BMP4, RARG, CHD7, PVRL1, VEGFA, 0.88888888 0.00581213 1352 2.63909481 0.99999998 0.03256545 9.98160 GO:0001654~eye development 12 PAX6, FOXC1, ZEB1, GLI3, STAT3, 466 132 9 7 8 1 1 9 4 TGFB2, APC
BMP4, FGF9, SMAD5, STAT5B, JAG2, 0.96296296 0.00591651 1352 2.49927521 0.99999998 0.03308164 10.1519 GO:0007548~sex differentiation 13 TP63, SOX9, CHD7, VEGFA, ASB1, 466 151 3 8 8 8 6 4 5 ROR2, FOXC1, PBX1
GO:0048538~thymus development 5 0.37037037 0.00616116 CRKL, SIX1, TBX1, PBX1, APC 466 22 1352 6.59773702 0.99999999 0.03436714 10.5500 7 8 7 3 9 1
0.00616116 1352 6.59773702 0.99999999 0.03436714 10.5500 GO:0048286~lung alveolus development 5 0.37037037 PTHLH, BMP4, VEGFA, TGFB3, FGF10 466 22 7 8 7 3 9 1
0.59259259 0.00620797 TNFRSF1A, EP300, PTK2B, APOE, 1352 3.62875536 0.99999999 10.6259 GO:0045471~response to ethanol 8 466 64 0.03456146 3 2 STAT5B, TLR4, PTEN, STAT3 8 5 4 8
IL6, TNF, PML, SMAD3, PRKDC, SOX4,
GO:0010608~posttranscriptional 1.18518518 0.00628283 IFI30, SMAD2, SMAD1, PTEN, UBE2B, 1352 2.20133026 0.99999999 0.03490865 10.7473 16 466 211 regulation of gene expression 5 4 TNFRSF1B, CDKN2A, PTK2B, VEGFA, 8 9 6 5 5
CD28
0.22222222 0.00675561 1352 21.7725321 0.99999999 0.03742656 GO:0002051~osteoblast fate commitment 3 SMAD5, SMAD1, RUNX2 466 4 11.5103 2 8 8 9 9 7
GO:0060556~regulation of vitamin D 0.22222222 0.00675561 1352 21.7725321 0.99999999 0.03742656 3 TNF, IFNG, NFKB1 466 4 11.5103 biosynthetic process 2 8 8 9 9 7
GO:0070423~nucleotide-binding 0.22222222 0.00675561 1352 21.7725321 0.99999999 0.03742656 oligomerization domain containing 3 RELA, NFKBIA, RIPK2 466 4 11.5103 2 8 8 9 9 7 signaling pathway
GO:0032909~regulation of transforming 0.22222222 0.00675561 1352 21.7725321 0.99999999 0.03742656 3 SMAD4, SMAD3, TGFB2 466 4 11.5103 growth factor-beta2 production 2 8 8 9 9 7
GO:0010940~positive regulation of 0.22222222 0.00675561 1352 21.7725321 0.99999999 0.03742656 3 TNF, RIPK1, FAS 466 4 11.5103 necrotic cell death 2 8 8 9 9 7
GO:0070431~nucleotide-binding 0.22222222 0.00675561 1352 21.7725321 0.99999999 0.03742656 oligomerization domain containing 2 3 RELA, NFKBIA, RIPK2 466 4 11.5103 2 8 8 9 9 7 signaling pathway
GO:0002437~inflammatory response to 0.22222222 0.00675561 1352 21.7725321 0.99999999 0.03742656 3 TNF, IL2RA, IL1B 466 4 11.5103 antigenic stimulus 2 8 8 9 9 7
GO:0030656~regulation of vitamin 3 0.22222222 0.00675561 TNF, IFNG, NFKB1 466 4 1352 21.7725321 0.99999999 0.03742656 11.5103 metabolic process 2 8 8 9 9 7
CAV1, TP53, TGFB1, EDNRB, VDR,
1.33333333 0.00679492 P2RX7, CCR6, SAA1, PTK2B, APOE, 1352 2.05724713 0.99999999 0.03757293 11.5734 GO:0030003~cellular cation homeostasis 18 466 254 3 9 MT2A, CCR2, RYR1, CAMK2D, IL1B, 8 6 9 3 6
NEDD4L, MYC, IL2
EGR2, EFNB1, RXRA, ERBB2, PAX6, 1.11111111 0.00687921 1352 2.25622095 0.99999999 0.03796303 11.7087 GO:0007409~axonogenesis 15 GLI2, VASP, IGF1R, NOTCH1, PVRL1, 466 193 1 6 8 2 9 7 4 S100B, DLX5, FOXG1, NGFR, APC
0.29629629 0.00704101 1352 9.67668097 0.03877157 11.9678 GO:0048566~embryonic gut development 4 FGF9, FGF10, GLI2, GLI3 466 12 1 6 1 8 3 3 7
GO:0045885~positive regulation of 0.29629629 0.00704101 1352 9.67668097 0.03877157 11.9678 4 CSF2, IL3, STAT5B, ESR2 466 12 1 survival gene product expression 6 1 8 3 3 7
0.29629629 0.00704101 1352 9.67668097 0.03877157 11.9678 GO:0008354~germ cell migration 4 PRKDC, FOXC1, KIT, TGFB1 466 12 1 6 1 8 3 3 7
GO:0010712~regulation of collagen 0.29629629 0.00704101 1352 9.67668097 0.03877157 11.9678 4 CIITA, IL6, TGFB3, TGFB1 466 12 1 metabolic process 6 1 8 3 3 7
GO:0014068~positive regulation of 0.29629629 0.00704101 1352 9.67668097 0.03877157 11.9678 4 GH1, NEDD4, ERBB2, TGFB2 466 12 1 phosphoinositide 3-kinase cascade 6 1 8 3 3 7
GO:0050718~positive regulation of 0.29629629 0.00704101 1352 9.67668097 0.03877157 11.9678 4 P2RX7, PANX1, IFNG, PYCARD 466 12 1 interleukin-1 beta secretion 6 1 8 3 3 7
GO:0070228~regulation of lymphocyte 0.29629629 0.00704101 1352 9.67668097 0.03877157 11.9678 4 BCL10, MYC, IL10, IL2 466 12 1 apoptosis 6 1 8 3 3 7
GO:0016202~regulation of striated 0.51851851 0.00705019 BMP4, NOG, NOTCH1, FGF9, ILK, 1352 4.06420600 0.03875163 11.9825 7 466 50 1 muscle tissue development 9 8 SMAD3, TGFB1 8 9 5 6
0.00725915 1352 6.31087889 0.03980961 GO:0001974~blood vessel remodeling 5 0.37037037 ATG5, VEGFA, FGF10, TBX1, FOXC1 466 23 1 12.3161 2 8 5 9 GO:0010332~response to gamma 0.00725915 1352 6.31087889 0.03980961 5 0.37037037 CAV1, SOCS3, PML, TP53, PRKDC 466 23 1 12.3161 radiation 2 8 5 9
GO:0043271~negative regulation of ion 0.00725915 1352 6.31087889 0.03980961 5 0.37037037 TNF, PTGS2, NEDD4, NEDD4L, TGFB1 466 23 1 12.3161 transport 2 8 5 9
GO:0009954~proximal/distal pattern 0.00725915 1352 6.31087889 0.03980961 5 0.37037037 TP63, PBX1, GLI2, GLI3, APC 466 23 1 12.3161 formation 2 8 5 9
GO:0031331~positive regulation of 0.44444444 0.00734630 1352 4.83834048 0.04020756 12.4548 6 IRS2, TNF, APOE, IFNG, IL1B, IRS1 466 36 1 cellular catabolic process 4 9 8 6 3 7
GO:0010741~negative regulation of 0.44444444 0.00734630 CAV1, P2RX7, SOCS1, TNFAIP3, PTEN, 1352 4.83834048 0.04020756 12.4548 6 466 36 1 protein kinase cascade 4 9 APC 8 6 3 7
EGFR, EGR2, EFNB1, RXRA, ERBB2,
1.33333333 0.00738177 PAX6, GLI2, VASP, SMO, IGF1R, 1352 2.04117489 0.04032632 12.5112 GO:0032990~cell part morphogenesis 18 466 256 1 3 5 NOTCH1, PVRL1, S100B, DLX5, ILK, 8 3 3 8
FOXG1, NGFR, APC
TRAF1, TRAF2, CAV1, PML, TP63,
CDH1, HLA-DMA, TGFB1, TAPBP,
IGF1R, TNFRSF1A, NOD1, PTK2B,
GO:0043933~macromolecular complex 2.81481481 0.00767020 APOE, TAP2, IL1RAP, ILK, FAS, MYC, 1352 1.55372060 0.04179996 12.9687 38 466 710 1 subunit organization 5 2 SYK, APC, BCL10, IRAK1, MLL, 8 7 8 5
CREBBP, SMAD4, TP53, SMAD3,
MALT1, SMAD2, SMAD1, CD40, IRS1,
TRIM21, P2RX7, TNFSF11, PRLR, IRF7
CAV1, TGFB1, EDNRB, VDR, P2RX7, GO:0006875~cellular metal ion 1.11111111 0.00784239 1352 2.22168695 13.2407 15 CCR6, PTK2B, APOE, SAA1, CCR2, 466 196 1 0.04264577 homeostasis 1 1 8 8 8 RYR1, CAMK2D, IL1B, NEDD4L, IL2
GO:0021700~developmental maturation 10 0.74074074 0.00791784 CDKN1C, NOTCH1, PTGS2, CD44, 466 101 1352 2.87426167 1 0.04297242 13.3597 1 4 PTK2B, VEGFA, RUNX2, CBFB, AXIN1, 8 5 4 3
TGFB2
GO:0048384~retinoic acid receptor 0.29629629 0.00892247 1352 8.93232089 0.04822977 4 RARG, RXRA, PML, RARA 466 13 1 14.9289 signaling pathway 6 9 8 8 7
GO:0042993~positive regulation of 0.29629629 0.00892247 1352 8.93232089 0.04822977 4 TNF, SMAD3, CDH1, EDA 466 13 1 14.9289 transcription factor import into nucleus 6 9 8 8 7
GO:0031056~regulation of histone 0.29629629 0.00892247 1352 8.93232089 0.04822977 4 UBE2N, MLL, PML, FOXP3 466 13 1 14.9289 modification 6 9 8 8 7
GO:0032770~positive regulation of 0.29629629 0.00892247 1352 8.93232089 0.04822977 4 TNF, APOE, IFNG, IL1B 466 13 1 14.9289 monooxygenase activity 6 9 8 8 7
0.29629629 0.00892247 1352 8.93232089 0.04822977 GO:0033198~response to ATP 4 P2RX7, PANX1, IL1B, PTEN 466 13 1 14.9289 6 9 8 8 7
0.29629629 0.00892247 1352 8.93232089 0.04822977 GO:0045061~thymic T cell selection 4 CARD11, JAG2, FAS, HLA-DMA 466 13 1 14.9289 6 9 8 8 7
GO:0014066~regulation of 0.29629629 0.00892247 1352 8.93232089 0.04822977 4 GH1, NEDD4, ERBB2, TGFB2 466 13 1 14.9289 phosphoinositide 3-kinase cascade 6 9 8 8 7
GO:0046640~regulation of alpha-beta T 0.29629629 0.00892247 1352 8.93232089 0.04822977 4 BTLA, CBLB, RIPK2, SYK 466 13 1 14.9289 cell proliferation 6 9 8 8 7
GO:0050706~regulation of interleukin-1 0.29629629 0.00892247 1352 8.93232089 0.04822977 4 P2RX7, PANX1, IFNG, PYCARD 466 13 1 14.9289 beta secretion 6 9 8 8 7
GO:0045072~regulation of 0.29629629 0.00892247 1352 8.93232089 0.04822977 4 TLR3, TLR7, TLR8, TLR9 466 13 1 14.9289 interferon-gamma biosynthetic process 6 9 8 8 7
0.29629629 0.00892247 1352 8.93232089 0.04822977 GO:0042100~B cell proliferation 4 CD40LG, CD40, IL7R, IL10 466 13 1 14.9289 6 9 8 8 7
0.96296296 0.00923994 IL6, FGF10, IL10, TGFB2, EDNRB, CCR6, 1352 2.35869098 0.04982226 15.4191 GO:0006935~chemotaxis 13 466 160 1 3 8 DEFA1B, SAA1, IFNG, CCR2, IL1B, 8 7 5 6 DEFA1, PTAFR, SYK
IL6, FGF10, IL10, TGFB2, EDNRB, CCR6, 0.96296296 0.00923994 1352 2.35869098 0.04982226 15.4191 GO:0042330~taxis 13 DEFA1B, SAA1, IFNG, CCR2, IL1B, 466 160 1 3 8 8 7 5 6 DEFA1, PTAFR, SYK
0.59259259 BMP4, RARG, PVRL1, VEGFA, PAX6, 1352 3.36580207 0.05014741 15.5396 GO:0048592~eye morphogenesis 8 0.00931825 466 69 1 3 ZEB1, GLI3, STAT3 8 8 2 7
0.59259259 SMO, CDKN1A, NOTCH1, SOCS3, 1352 3.36580207 0.05014741 15.5396 GO:0031099~regeneration 8 0.00931825 466 69 1 3 RXRA, SOCS1, FGF10, TGFB1 8 8 2 7
RNF144B, UBE2A, UBE4A, UBE2G2,
GO:0006511~ubiquitin-dependent protein 1.25925925 0.00956082 FBXO2, UBR2, UBR1, PARK2, TRIM63, 1352 2.03930053 0.05133477 15.9119 17 466 242 1 catabolic process 9 7 UBE2B, CUL3, CYLD, CUL7, NEDD4, 8 6 6 7
TRIM32, FBXO6, FBXO4
GO:0045862~positive regulation of 0.00982495 1352 5.80600858 0.05262963 16.3155 5 0.37037037 TNF, EP300, APOE, IFNG, IL1B 466 25 1 proteolysis 7 8 4 2 9
0.00982495 1352 5.80600858 0.05262963 16.3155 GO:0021675~nerve development 5 0.37037037 SMO, CHD7, EGR2, NGFR, GLI3 466 25 1 7 8 4 2 9
0.00982495 1352 5.80600858 0.05262963 16.3155 GO:0048730~epidermis morphogenesis 5 0.37037037 NOTCH1, TP63, NGFR, COL1A1, TGFB2 466 25 1 7 8 4 2 9
CAV1, PTGS2, ERBB2, STAT5B, TGFB3,
JAG2, PRKDC, ZBTB16, KIT, TGFB1,
GO:0032504~multicellular organism 2.07407407 0.01003833 TGFB2, PTK2B, PRL, OCA2, AXIN1, 1352 1.66907844 0.05365329 16.6403 28 466 487 1 reproduction 4 4 BMP4, EGFR, BMP2, SMAD5, LMNA, 8 3 7 1
UBR2, SMAD1, UBE2B, PTHLH,
NOTCH1, PRLR, VEGFA, FOXC1
GO:0048609~reproductive process in a 2.07407407 0.01003833 CAV1, PTGS2, ERBB2, STAT5B, TGFB3, 1352 1.66907844 0.05365329 16.6403 28 466 487 1 multicellular organism 4 4 JAG2, PRKDC, ZBTB16, KIT, TGFB1, 8 3 7 1 TGFB2, PTK2B, PRL, OCA2, AXIN1,
BMP4, EGFR, BMP2, SMAD5, LMNA,
UBR2, SMAD1, UBE2B, PTHLH,
NOTCH1, PRLR, VEGFA, FOXC1
GO:0016064~immunoglobulin mediated 0.51851851 BCL10, MYD88, CD40LG, INPP5D, 1352 3.76315371 0.05449789 16.9131 7 0.01021822 466 54 1 immune response 9 HLA-DMA, TLR8, HLA-DRA 8 2 6 5
0.59259259 0.01083641 LRSAM1, PVRL1, NEDD4, IRF7, CD81, 1352 3.27099075 0.05761546 17.8443 GO:0016032~viral reproduction 8 466 71 1 3 6 CALCOCO2, SMAD3, TGFB1 8 1 7 5
CAV1, EP300, ATG5, MEOX2, ERBB2, 0.81481481 0.01097894 1352 2.55464377 0.05825386 18.0576 GO:0060537~muscle tissue development 11 RXRA, SIX1, TP63, FOXC1, PTEN, 466 125 1 5 6 8 7 7 4 TGFB2
GO:0007253~cytoplasmic sequestering of 0.22222222 0.01100389 1352 17.4180257 0.05828223 18.0949 3 NFKBIB, NFKBIA, IL10 466 5 1 NF-kappaB 2 7 8 5 1 3
GO:0010939~regulation of necrotic cell 0.22222222 0.01100389 1352 17.4180257 0.05828223 18.0949 3 TNF, RIPK1, FAS 466 5 1 death 2 7 8 5 1 3
GO:0045589~regulation of regulatory T 0.22222222 0.01100389 1352 17.4180257 0.05828223 18.0949 3 CTLA4, IL2RG, IL2 466 5 1 cell differentiation 2 7 8 5 1 3
GO:0032715~negative regulation of 0.22222222 0.01100389 1352 17.4180257 0.05828223 18.0949 3 IRAK3, TNF, IL10 466 5 1 interleukin-6 production 2 7 8 5 1 3
GO:0045348~positive regulation of MHC 0.22222222 0.01100389 1352 17.4180257 0.05828223 18.0949 3 CIITA, IFNG, IL10 466 5 1 class II biosynthetic process 2 7 8 5 1 3
GO:0031053~primary microRNA 0.22222222 0.01100389 1352 17.4180257 0.05828223 18.0949 3 SMAD3, SMAD2, SMAD1 466 5 1 processing 2 7 8 5 1 3
0.22222222 0.01100389 1352 17.4180257 0.05828223 18.0949 GO:0002360~T cell lineage commitment 3 IL7, TP53, PRKDC 466 5 1 2 7 8 5 1 3
GO:0002230~positive regulation of 3 0.22222222 0.01100389 MAVS, DDX58, PML 466 5 1352 17.4180257 1 0.05828223 18.0949 defense response to virus by host 2 7 8 5 1 3
GO:0021904~dorsal/ventral neural tube 0.29629629 0.01107002 1352 8.29429797 0.05852286 18.1936 4 BMP4, SMO, FOXA2, GLI2 466 14 1 patterning 6 2 8 7 7 6
GO:0051220~cytoplasmic sequestering of 0.29629629 0.01107002 1352 8.29429797 0.05852286 18.1936 4 NFKBIE, NFKBIB, NFKBIA, IL10 466 14 1 protein 6 2 8 7 7 6
GO:0042992~negative regulation of 0.29629629 0.01107002 1352 8.29429797 0.05852286 18.1936 4 NFKBIE, NFKBIB, NFKBIA, IL10 466 14 1 transcription factor import into nucleus 6 2 8 7 7 6
0.29629629 0.01107002 1352 8.29429797 0.05852286 18.1936 GO:0035265~organ growth 4 RXRA, SMAD2, FOXC1, TGFB2 466 14 1 6 2 8 7 7 6
0.51851851 0.01114618 TXNIP, EGFR, CAV1, P2RX7, EP300, 1352 3.69473273 0.05881428 18.3072 GO:0051592~response to calcium ion 7 466 55 1 9 6 NEDD4, PTK2B 8 5 9 4
GO:0045766~positive regulation of 0.01130252 TNFRSF1A, ERAP1, IL1B, TNFSF12, 1352 5.58270056 0.05951640 18.5399 5 0.37037037 466 26 1 angiogenesis 9 IL1A 8 1 9 4
GO:0051353~positive regulation of 0.01130252 1352 5.58270056 0.05951640 18.5399 5 0.37037037 VDR, TNF, APOE, IFNG, IL1B 466 26 1 oxidoreductase activity 9 8 1 9 4
0.01130252 1352 5.58270056 0.05951640 18.5399 GO:0035137~hindlimb morphogenesis 5 0.37037037 NOTCH1, RARG, CHD7, LRP6, ZBTB16 466 26 1 9 8 1 9 4
CAV1, TGFB1, EDNRB, VDR, P2RX7, 1.11111111 0.01138335 1352 2.12414948 18.6599 GO:0055065~metal ion homeostasis 15 CCR6, PTK2B, APOE, SAA1, CCR2, 466 205 1 0.05982874 1 9 8 2 9 RYR1, CAMK2D, IL1B, NEDD4L, IL2
0.44444444 0.01146624 MAP3K7, BCL10, TFAP2A, PAX3, 1352 4.35450643 0.06015040 18.7829 GO:0001841~neural tube formation 6 466 40 1 4 2 TRAF6, VASP 8 8 4 2
GO:0001704~formation of primary germ 0.44444444 0.01146624 BMP4, FOXA2, SMAD3, SMAD2, 1352 4.35450643 0.06015040 18.7829 6 466 40 1 layer 4 2 FOXC1, SMAD1 8 8 4 2
GO:0051224~negative regulation of 0.44444444 0.01146624 TNF, NFKBIE, NFKBIB, NFKBIA, 1352 4.35450643 0.06015040 18.7829 6 466 40 1 protein transport 4 2 FOXP3, IL10 8 8 4 2 GO:0051783~regulation of nuclear 0.51851851 0.01213217 TNF, CUL7, HECTD3, IL1B, IL1A, CD28, 1352 3.62875536 0.06344287 19.7642 7 466 56 1 division 9 3 APC 8 5 6 8
0.51851851 0.01213217 TNF, CUL7, HECTD3, IL1B, IL1A, CD28, 1352 3.62875536 0.06344287 19.7642 GO:0007088~regulation of mitosis 7 466 56 1 9 3 APC 8 5 6 8
0.51851851 0.01213217 CHD7, FGF9, DLX5, FOXG1, SIX1, 1352 3.62875536 0.06344287 19.7642 GO:0042472~inner ear morphogenesis 7 466 56 1 9 3 FGF10, TBX1 8 5 6 8
GO:0043523~regulation of neuron 0.66666666 0.01214478 TNF, ILK, TGFB3, TP53, ESR2, NQO1, 1352 2.90300429 19.7827 9 466 90 1 0.06339909 apoptosis 7 7 TP73, GHR, TGFB2 8 2 6
GO:0032507~maintenance of protein 0.44444444 0.01269976 CAV1, NFKBIE, NFKBIB, PML, NFKBIA, 1352 4.24829896 0.06610390 20.5918 6 466 41 1 location in cell 4 9 IL10 8 4 7 8
EGFR, BMP4, BMP2, EGR2, NR1D1, 0.81481481 0.01283164 1352 2.49476931 0.06665825 20.7830 GO:0048511~rhythmic process 11 ERBB2, VEGFA, STAT5B, TGFB3, 466 128 1 5 7 8 3 7 1 FOXC1, TGFB2
0.01291579 1352 5.37593387 0.06696990 20.9047 GO:0042098~T cell proliferation 5 0.37037037 P2RX7, CRTAM, TP53, RIPK2, MALT1 466 27 1 9 8 4 8 4
GO:0010552~positive regulation of 0.51851851 0.01317793 NOTCH1, TP53, SMAD3, NFKBIA, 1352 0.06817535 21.2828 specific transcription from RNA 7 466 57 3.56509299 1 9 9 PRKDC, IRF4, FOXP3 8 5 2 polymerase II promoter
GO:0048704~embryonic skeletal system 0.51851851 0.01317793 NOG, SIX1, TGFB3, TFAP2A, TBX1, 1352 0.06817535 21.2828 7 466 57 3.56509299 1 morphogenesis 9 9 ZEB1, GLI3 8 5 2
EGR2, EFNB1, RXRA, ERBB2, PAX6, GO:0048667~cell morphogenesis 1.11111111 0.01329418 1352 2.08349590 0.06864390 21.4499 15 GLI2, VASP, IGF1R, NOTCH1, PVRL1, 466 209 1 involved in neuron differentiation 1 5 8 3 1 3 S100B, DLX5, FOXG1, NGFR, APC
GO:0045124~regulation of bone 0.29629629 0.01348983 1352 7.74134477 0.06950798 21.7304 4 P2RX7, TNFSF11, VEGFA, INPP5D 466 15 1 resorption 6 4 8 8 7 3
GO:0046850~regulation of bone 4 0.29629629 0.01348983 P2RX7, TNFSF11, VEGFA, INPP5D 466 15 1352 7.74134477 1 0.06950798 21.7304 remodeling 6 4 8 8 7 3
TXNIP, EGFR, CAV1, P2RX7, EP300, 0.81481481 0.01349865 1352 2.47543001 0.06943564 21.7430 GO:0010038~response to metal ion 11 PTGS2, NEDD4, PTK2B, RXRA, 466 129 1 5 2 8 6 8 5 NEDD4L, PTEN
0.44444444 0.01402002 BMP4, BMP2, RARG, CD44, RXRA, 1352 4.14714898 22.4858 GO:0033189~response to vitamin A 6 466 42 1 0.07191667 4 9 RARA 8 8 2
0.74074074 0.01422095 EGR1, FOS, EGR2, PTGS2, S100B, IL1B, 1352 2.61531918 0.07279449 22.7702 GO:0007611~learning or memory 10 466 111 1 1 3 KIT, PARK2, ESR2, PTEN 8 2 7 9
CAV1, RXRA, ERBB2, LMNA, TP63, 1.11111111 0.01431869 1352 2.06374712 22.9083 GO:0007517~muscle organ development 15 TBX1, PAX3, PTEN, TGFB2, EP300, 466 211 1 0.07315772 1 9 8 7 1 MSX1, MEOX2, ATG5, SIX1, FOXC1
GO:0000302~response to reactive oxygen 0.59259259 0.01439869 TXNIP, FOS, EP300, PTK2B, APOE, 1352 3.09653791 0.07343184 8 466 75 1 23.0211 species 3 5 RELA, COL1A1, STAT1 8 1 8
0.01466875 1352 5.18393623 0.07464240 23.4007 GO:0007595~lactation 5 0.37037037 PTHLH, CAV1, PRLR, STAT5B, PRL 466 28 1 6 8 5 1 3
GO:0001838~embryonic epithelial tube 0.44444444 0.01542949 MAP3K7, BCL10, TFAP2A, PAX3, 1352 4.05070366 0.07825744 6 466 43 1 24.4606 formation 4 1 TRAF6, VASP 8 3 2
E2F1, BMP4, NOG, NOTCH1, MSX1, 0.88888888 0.01585694 1352 2.29184549 0.08022053 25.0500 GO:0030900~forebrain development 12 FOXG1, PAX6, CDH1, PRKG1, GLI2, 466 152 1 9 8 8 4 2 5 GLI3, TP73
0.22222222 0.01613243 HLA-DRB1, HLA-DRB4, HLA-DPB1, 1352 14.5150214 25.4276 GO:0009405~pathogenesis 3 466 6 1 0.08143286 2 1 TNIP1 8 6 3
GO:0048304~positive regulation of 0.22222222 0.01613243 1352 14.5150214 25.4276 3 IFNG, CD40, IL2 466 6 1 0.08143286 isotype switching to IgG isotypes 2 1 8 6 3
GO:0002857~positive regulation of 0.22222222 0.01613243 1352 14.5150214 25.4276 3 PVR, CRTAM, CD226 466 6 1 0.08143286 natural killer cell mediated immune 2 1 8 6 3 response to tumor cell
0.22222222 0.01613243 1352 14.5150214 25.4276 GO:0051865~protein autoubiquitination 3 LRSAM1, UBE2A, UBE2B 466 6 1 0.08143286 2 1 8 6 3
GO:0002860~positive regulation of 0.22222222 0.01613243 1352 14.5150214 25.4276 natural killer cell mediated cytotoxicity 3 PVR, CRTAM, CD226 466 6 1 0.08143286 2 1 8 6 3 directed against tumor cell target
GO:0002855~regulation of natural killer 0.22222222 0.01613243 1352 14.5150214 25.4276 cell mediated immune response to tumor 3 PVR, CRTAM, CD226 466 6 1 0.08143286 2 1 8 6 3 cell
GO:0002858~regulation of natural killer 0.22222222 0.01613243 1352 14.5150214 25.4276 cell mediated cytotoxicity directed against 3 PVR, CRTAM, CD226 466 6 1 0.08143286 2 1 8 6 3 tumor cell target
GO:0070372~regulation of ERK1 and 0.22222222 0.01613243 1352 14.5150214 25.4276 3 NOD1, RIPK2, TLR4 466 6 1 0.08143286 ERK2 cascade 2 1 8 6 3
GO:0051797~regulation of hair follicle 0.22222222 0.01613243 1352 14.5150214 25.4276 3 TNF, NGFR, TGFB2 466 6 1 0.08143286 development 2 1 8 6 3
GO:0070374~positive regulation of 0.22222222 0.01613243 1352 14.5150214 25.4276 3 NOD1, RIPK2, TLR4 466 6 1 0.08143286 ERK1 and ERK2 cascade 2 1 8 6 3
0.22222222 0.01613243 1352 14.5150214 25.4276 GO:0042634~regulation of hair cycle 3 TNF, NGFR, TGFB2 466 6 1 0.08143286 2 1 8 6 3
0.22222222 0.01613243 1352 14.5150214 25.4276 GO:0030316~osteoclast differentiation 3 TNFSF11, TNF, CHUK 466 6 1 0.08143286 2 1 8 6 3
GO:0032735~positive regulation of 0.22222222 0.01613243 1352 14.5150214 25.4276 3 CD40LG, IFNG, CD40 466 6 1 0.08143286 interleukin-12 production 2 1 8 6 3
GO:0001959~regulation of 0.29629629 0.01618646 1352 0.08156250 25.5014 4 IRAK2, IRAK1, IRAK3, CAV1 466 16 7.25751073 1 cytokine-mediated signaling pathway 6 5 8 7 8 GO:0042308~negative regulation of 0.29629629 0.01618646 1352 0.08156250 25.5014 4 NFKBIE, NFKBIB, NFKBIA, IL10 466 16 7.25751073 1 protein import into nucleus 6 5 8 7 8
EGFR, EGR1, EDNRB, TNF, EGR2, GO:0031644~regulation of neurological 0.88888888 0.01657736 1352 2.27686611 26.0336 12 PTGS2, APOE, IFNG, KIT, PARK2, 466 153 1 0.0833272 system process 9 8 8 1 7 CAMK2A, IL10
TNF, FGF9, TP53, TGFB3, PML, NFKBIA, 1.11111111 0.01666579 1352 2.02535183 0.08361956 26.1535 GO:0006605~protein targeting 15 FGF10, GLI3, TGFB1, TGFB2, CBLB, 466 215 1 1 3 8 2 7 6 NEDD4, IFNG, PRL, SEC61G
0.44444444 0.01693050 MAP3K7, BCL10, TFAP2A, PAX3, 1352 3.95864221 0.08476251 26.5113 GO:0035148~tube lumen formation 6 466 44 1 4 2 TRAF6, VASP 8 6 2 5
GO:0060627~regulation of 0.66666666 0.01741489 CAV1, LRSAM1, CBL, FGF10, RAPGEF4, 1352 2.72156652 0.08695805 27.1618 9 466 96 1 vesicle-mediated transport 7 4 NEDD4L, PTEN, TGFB1, SYK 8 4 8 5
GO:0040014~regulation of multicellular 0.51851851 0.01799244 GH1, CHD7, APOE, STAT5B, PRL, 1352 0.08958862 27.9303 7 466 61 3.3313164 1 organism growth 9 5 STAT3, GHR 8 5 4
0.51851851 0.01799244 FOS, CDKN1A, BLMH, CDH1, FAS, 1352 0.08958862 27.9303 GO:0009636~response to toxin 7 466 61 3.3313164 1 9 5 IKBKB, NQO1 8 5 4
GO:0031329~regulation of cellular 0.51851851 0.01799244 1352 0.08958862 27.9303 7 IRS2, TNF, APOE, IFNG, IL1B, IRS1, IL10 466 61 3.3313164 1 catabolic process 9 5 8 5 4
0.51851851 0.01799244 CAV1, LRSAM1, CBL, FGF10, NEDD4L, 1352 0.08958862 27.9303 GO:0030100~regulation of endocytosis 7 466 61 3.3313164 1 9 5 PTEN, TGFB1 8 5 4
GO:0033044~regulation of chromosome 0.01860786 1352 4.83834048 28.7407 5 0.37037037 UBE2N, MLL, PML, FOXP3, MYC 466 30 1 0.09238511 organization 2 8 6 8
0.01860786 1352 4.83834048 28.7407 GO:0032368~regulation of lipid transport 5 0.37037037 P2RX7, IRS2, APOE, NFKBIA, NFKB1 466 30 1 0.09238511 2 8 6 8
0.01860786 1352 4.83834048 28.7407 GO:0060606~tube closure 5 0.37037037 BCL10, TFAP2A, PAX3, TRAF6, VASP 466 30 1 0.09238511 2 8 6 8 0.01860786 1352 4.83834048 28.7407 GO:0001843~neural tube closure 5 0.37037037 BCL10, TFAP2A, PAX3, TRAF6, VASP 466 30 1 0.09238511 2 8 6 8
GO:0050729~positive regulation of 0.01860786 1352 4.83834048 28.7407 5 0.37037037 TNFRSF1A, IL6, STAT5B, TLR4, LBP 466 30 1 0.09238511 inflammatory response 2 8 6 8
CAV1, EGR2, ERBB2, TP53, TGFB1,
EDNRB, VDR, P2RX7, CCR6, SAA1, 0.01903820 1352 1.70764958 0.09428540 29.3023 GO:0006873~cellular ion homeostasis 22 1.62962963 APOE, PTK2B, MT2A, ILK, CCR2, RYR1, 466 374 1 2 8 3 1 8 CAMK2D, IL1B, NEDD4L, MYC, IFI6,
IL2
GO:0044246~regulation of multicellular 0.29629629 0.01916295 1352 6.83059833 0.09472650 4 CIITA, IL6, TGFB3, TGFB1 466 17 1 29.4644 organismal metabolic process 6 5 8 4 9
GO:0042787~protein ubiquitination 0.29629629 0.01916295 1352 6.83059833 0.09472650 during ubiquitin-dependent protein 4 RNF144B, NEDD4, TRIM32, PARK2 466 17 1 29.4644 6 5 8 4 9 catabolic process
GO:0050850~positive regulation of 0.29629629 0.01916295 1352 6.83059833 0.09472650 4 NCAM1, CD8A, TRAT1, SYK 466 17 1 29.4644 calcium-mediated signaling 6 5 8 4 9
GO:0042516~regulation of tyrosine 0.29629629 0.01916295 1352 6.83059833 0.09472650 4 GH1, IL6, SOCS1, GHR 466 17 1 29.4644 phosphorylation of Stat3 protein 6 5 8 4 9
GO:0002474~antigen processing and 0.29629629 0.01916295 1352 6.83059833 0.09472650 presentation of peptide antigen via MHC 4 TAP2, ERAP1, ERAP2, TAPBP 466 17 1 29.4644 6 5 8 4 9 class I
0.51851851 0.01936192 BMP4, ERBB2, VEGFA, STAT5B, 1352 3.27758549 0.09551753 29.7220 GO:0022602~ovulation cycle process 7 466 62 1 9 7 TGFB3, FOXC1, TGFB2 8 1 8 8
0.51851851 0.01936192 LRSAM1, PVRL1, NEDD4, IRF7, CD81, 1352 3.27758549 0.09551753 29.7220 GO:0022415~viral reproductive process 7 466 62 1 9 7 SMAD3, TGFB1 8 1 8 8
GO:0030855~epithelial cell 11 0.81481481 0.01980670 TXNIP, PTHLH, FOXA2, IRF6, DLX5, 466 137 1352 2.33087935 1 0.09746619 30.2948 differentiation 5 3 VEGFA, SIX1, PAX6, TP63, MADCAM1, 8 8 9
SFN
PTGS2, IL18, FGF10, KIT, PTEN, IL10,
TGFB2, FOS, EDNRB, DEFA1B, CHD7, 1.92592592 1352 1.60934139 0.09875483 30.6871 GO:0007610~behavior 26 0.02011329 SAA1, IFNG, IL1B, SYK, EGR1, IL6, 466 469 1 6 8 8 9 6 EGR2, TBX1, PARK2, ESR2, STAT3,
CCR6, S100B, CCR2, DEFA1, PTAFR
GO:0030111~regulation of Wnt receptor 0.44444444 0.02021594 1352 3.78652733 0.09908019 30.8180 6 FGF9, LRP6, SOX4, FGF10, AXIN1, APC 466 46 1 signaling pathway 4 4 8 7 6 3
CAV1, TP53, TGFB1, EDNRB, VDR,
1.33333333 0.02028409 P2RX7, CCR6, SAA1, PTK2B, APOE, 1352 1.82706563 0.09924262 30.9047 GO:0055080~cation homeostasis 18 466 286 1 3 7 MT2A, CCR2, RYR1, CAMK2D, IL1B, 8 8 3 9
NEDD4L, MYC, IL2
GO:0051480~cytosolic calcium ion 0.74074074 0.02044183 EDNRB, CAV1, P2RX7, CCR6, SAA1, 1352 2.46017312 0.09982377 31.1052 10 466 118 1 homeostasis 1 8 PTK2B, CCR2, RYR1, IL1B, IL2 8 9 8 1
0.02080015 1352 4.68226498 0.10133888 31.5584 GO:0043112~receptor metabolic process 5 0.37037037 TNF, NEDD4, IL10, TGFB1, GHR 466 31 1 9 8 7 8 3
GO:0014706~striated muscle tissue 0.74074074 0.02146887 CAV1, EP300, ATG5, MEOX2, ERBB2, 1352 2.43949940 0.10428986 32.3967 10 466 119 1 development 1 8 RXRA, SIX1, FOXC1, PTEN, TGFB2 8 5 5 3
0.44444444 0.02200443 TXNIP, PTGS2, PTK2B, SMAD2, PTEN, 1352 3.70596292 0.10660739 GO:0009746~response to hexose stimulus 6 466 47 1 33.0611 4 8 TGFB1 8 6 5
GO:0034284~response to 0.44444444 0.02200443 TXNIP, PTGS2, PTK2B, SMAD2, PTEN, 1352 3.70596292 0.10660739 6 466 47 1 33.0611 monosaccharide stimulus 4 8 TGFB1 8 6 5
GO:0014855~striated muscle cell 0.22222222 0.02207594 1352 12.4414469 0.10677078 33.1493 3 RXRA, FOXC1, TGFB2 466 7 1 proliferation 2 7 8 7 1 4
GO:0031058~positive regulation of 3 0.22222222 0.02207594 UBE2N, PML, FOXP3 466 7 1352 12.4414469 1 0.10677078 33.1493 histone modification 2 7 8 7 1 4
GO:0060038~cardiac muscle cell 0.22222222 0.02207594 1352 12.4414469 0.10677078 33.1493 3 RXRA, FOXC1, TGFB2 466 7 1 proliferation 2 7 8 7 1 4
GO:0030949~positive regulation of 0.22222222 0.02207594 1352 12.4414469 0.10677078 33.1493 vascular endothelial growth factor 3 FGF9, VEGFA, FGF10 466 7 1 2 7 8 7 1 4 receptor signaling pathway
0.22222222 0.02207594 1352 12.4414469 0.10677078 33.1493 GO:0060419~heart growth 3 RXRA, FOXC1, TGFB2 466 7 1 2 7 8 7 1 4
GO:0001916~positive regulation of T cell 0.22222222 0.02207594 1352 12.4414469 0.10677078 33.1493 3 PVR, P2RX7, TAP2 466 7 1 mediated cytotoxicity 2 7 8 7 1 4
GO:0002320~lymphoid progenitor cell 0.22222222 0.02207594 1352 12.4414469 0.10677078 33.1493 3 PRKDC, SOX4, KIT 466 7 1 differentiation 2 7 8 7 1 4
GO:0014065~phosphoinositide 3-kinase 0.22222222 0.02207594 1352 12.4414469 0.10677078 33.1493 3 IGF1R, ERBB2, IRS1 466 7 1 cascade 2 7 8 7 1 4
GO:0055017~cardiac muscle tissue 0.22222222 0.02207594 1352 12.4414469 0.10677078 33.1493 3 RXRA, FOXC1, TGFB2 466 7 1 growth 2 7 8 7 1 4
GO:0042347~negative regulation of 0.22222222 0.02207594 1352 12.4414469 0.10677078 33.1493 3 NFKBIB, NFKBIA, IL10 466 7 1 NF-kappaB import into nucleus 2 7 8 7 1 4
GO:0040036~regulation of fibroblast 0.22222222 0.02207594 1352 12.4414469 0.10677078 33.1493 3 FGF9, NGFR, RUNX2 466 7 1 growth factor receptor signaling pathway 2 7 8 7 1 4
GO:0032722~positive regulation of 0.22222222 0.02207594 1352 12.4414469 0.10677078 33.1493 3 IL6, TNF, RIPK2 466 7 1 chemokine production 2 7 8 7 1 4
CAV1, EGR2, ERBB2, TP53, TGFB1,
GO:0055082~cellular chemical 0.02227988 EDNRB, VDR, P2RX7, CCR6, SAA1, 1352 1.68068669 0.10754418 33.4003 22 1.62962963 466 380 1 homeostasis 3 APOE, PTK2B, MT2A, ILK, CCR2, RYR1, 8 5 8 9
CAMK2D, IL1B, NEDD4L, MYC, IFI6, IL2
GO:0031668~cellular response to 0.51851851 0.02231036 VDR, FOS, CDKN1A, CAV1, P2RX7, 1352 3.17516094 0.10751661 33.4378 7 466 64 1 extracellular stimulus 9 4 ATG5, TP53 8 4 2 4
0.29629629 0.02242096 1352 6.45112064 0.10785718 33.5735 GO:0007492~endoderm development 4 PTHLH, NOTCH1, PAX9, TGFB1 466 18 1 6 1 8 9 1 4
GO:0002763~positive regulation of 0.29629629 0.02242096 1352 6.45112064 0.10785718 33.5735 4 IL5, TNFSF11, KITLG, RB1 466 18 1 myeloid leukocyte differentiation 6 1 8 9 1 4
GO:0046823~negative regulation of 0.29629629 0.02242096 1352 6.45112064 0.10785718 33.5735 4 NFKBIE, NFKBIB, NFKBIA, IL10 466 18 1 nucleocytoplasmic transport 6 1 8 9 1 4
0.29629629 0.02242096 1352 6.45112064 0.10785718 33.5735 GO:0019915~lipid storage 4 CAV1, TNF, STAT5B, IL1B 466 18 1 6 1 8 9 1 4
GO:0000187~activation of MAPK 0.59259259 0.02252103 P2RX7, TNF, RIPK1, CD81, TGFB3, IL1B, 1352 2.83219930 0.10814829 8 466 82 1 33.6961 activity 3 1 GHR, SYK 8 9 3
0.51851851 EGFR, NOTCH1, EGR2, PTK2B, ERBB2, 1352 3.12631231 0.11423916 GO:0042063~gliogenesis 7 0.02389207 466 65 1 35.3539 9 SOX11, TGFB2 8 4 8
GO:0045185~maintenance of protein 0.44444444 0.02389259 CAV1, NFKBIE, NFKBIB, PML, NFKBIA, 1352 3.62875536 0.11406511 35.3545 6 466 48 1 location 4 8 IL10 8 5 5 3
EGFR, CAV1, TNF, TP53, PML, SMAD3,
GO:0051336~regulation of hydrolase 1.48148148 0.02411592 CDH1, SFN, STAT1, NLRP1, TGFB2, 1352 1.72285121 0.11490242 35.6208 20 466 337 1 activity 1 8 EDNRB, CDKN2A, NOD1, TNFRSF10B, 8 2 9 3
PTK2B, IFNG, PYCARD, MYC, IFI6
BMP4, TRIM36, PTK2B, SMAD5, GO:0048610~reproductive cellular 0.88888888 0.02420566 1352 0.11513186 35.7275 12 PRKDC, FOXC1, ZBTB16, KIT, UBE2B, 466 162 2.15037355 1 process 9 1 8 6 4 OCA2, TGFB1, AXIN1
GO:0006874~cellular calcium ion 0.96296296 0.02430969 CAV1, TGFB1, EDNRB, VDR, P2RX7, 1352 2.06224348 0.11542513 35.8510 13 466 183 1 homeostasis 3 2 CCR6, PTK2B, APOE, SAA1, CCR2, 8 6 4 4 RYR1, IL1B, IL2
CAV1, TGFB1, EDNRB, VDR, P2RX7, GO:0030005~cellular di-, tri-valent 1.11111111 0.02528172 1352 1.91828477 0.11962506 36.9942 15 CCR6, PTK2B, APOE, SAA1, CCR2, 466 227 1 inorganic cation homeostasis 1 5 8 4 3 1 MT2A, RYR1, IL1B, MYC, IL2
1352 4.39849135 0.12106187 37.4140 GO:0032526~response to retinoic acid 5 0.37037037 0.02564288 BMP4, BMP2, RARG, RXRA, RARA 466 33 1 8 1 6 2
GO:0045639~positive regulation of 1352 4.39849135 0.12106187 37.4140 5 0.37037037 0.02564288 IL5, TNFSF11, KITLG, RB1, INPP5D 466 33 1 myeloid cell differentiation 8 1 6 2
1352 4.39849135 0.12106187 37.4140 GO:0007569~cell aging 5 0.37037037 0.02564288 CDKN2A, ILK, PML, TP53, TP63 466 33 1 8 1 6 2
GO:0045665~negative regulation of 1352 4.39849135 0.12106187 37.4140 5 0.37037037 0.02564288 NOTCH1, FOXA2, FOXG1, PAX6, PBX1 466 33 1 neuron differentiation 8 1 6 2
GO:0014020~primary neural tube 1352 4.39849135 0.12106187 37.4140 5 0.37037037 0.02564288 BCL10, TFAP2A, PAX3, TRAF6, VASP 466 33 1 formation 8 1 6 2
GO:0008630~DNA damage response, 1352 4.39849135 0.12106187 37.4140 signal transduction resulting in induction 5 0.37037037 0.02564288 PML, TP53, TP63, SFN, TP73 466 33 1 8 1 6 2 of apoptosis
GO:0050926~regulation of positive 0.29629629 0.02596087 1352 6.11158798 0.12229943 37.7814 4 VEGFA, SMAD3, FGF10, AGER 466 19 1 chemotaxis 6 7 8 3 3 8
0.29629629 0.02596087 1352 6.11158798 0.12229943 37.7814 GO:0021545~cranial nerve development 4 SMO, CHD7, EGR2, GLI3 466 19 1 6 7 8 3 3 8
GO:0050688~regulation of defense 0.29629629 0.02596087 1352 6.11158798 0.12229943 37.7814 4 MAVS, DDX58, PML, CD28 466 19 1 response to virus 6 7 8 3 3 8
0.29629629 0.02596087 1352 6.11158798 0.12229943 37.7814 GO:0001502~cartilage condensation 4 THRA, CTGF, ROR2, SOX9 466 19 1 6 7 8 3 3 8
GO:0034103~regulation of tissue 4 0.29629629 0.02596087 P2RX7, TNFSF11, VEGFA, INPP5D 466 19 1352 6.11158798 1 0.12229943 37.7814 remodeling 6 7 8 3 3 8
GO:0050927~positive regulation of 0.29629629 0.02596087 1352 6.11158798 0.12229943 37.7814 4 VEGFA, SMAD3, FGF10, AGER 466 19 1 positive chemotaxis 6 7 8 3 3 8
0.29629629 0.02596087 1352 6.11158798 0.12229943 37.7814 GO:0048536~spleen development 4 FGF10, PBX1, NFKB2, FAS 466 19 1 6 7 8 3 3 8
0.29629629 0.02596087 1352 6.11158798 0.12229943 37.7814 GO:0031069~hair follicle morphogenesis 4 NOTCH1, TP63, NGFR, TGFB2 466 19 1 6 7 8 3 3 8
GO:0048871~multicellular organismal 0.59259259 0.02681537 PTHLH, P2RX7, TNFSF11, IL7, VEGFA, 1352 2.73223933 38.7588 8 466 85 1 0.12592016 homeostasis 3 4 IL1B, STAT3, IL1A 8 4 2
EGFR, SEC23A, SEC24B, TNF, FGF9,
TP53, TGFB3, PML, PAX6, NFKBIA, 1.70370370 0.02691103 1352 0.12615420 38.8673 GO:0034613~cellular protein localization 23 FGF10, GLI3, TGFB1, TGFB2, CBLB, 466 411 1.62455228 1 4 4 8 5 2 NEDD4, TAP2, IFNG, SEC24C, SEC24D,
PRL, SEC61G, SEC61A2
GO:0032102~negative regulation of 0.44444444 0.02797455 TNFRSF1B, IL2RA, SAA1, APOE, IL10, 1352 0.13066786 40.0614 6 466 50 3.48360515 1 response to external stimulus 4 5 IL2 8 9 8
GO:0002839~positive regulation of 0.22222222 0.02877260 1352 10.8862660 0.13398310 40.9430 3 PVR, CRTAM, CD226 466 8 1 immune response to tumor cell 2 4 8 9 6 5
GO:0002836~positive regulation of 0.22222222 0.02877260 1352 10.8862660 0.13398310 40.9430 3 PVR, CRTAM, CD226 466 8 1 response to tumor cell 2 4 8 9 6 5
0.22222222 0.02877260 1352 10.8862660 0.13398310 40.9430 GO:0042481~regulation of odontogenesis 3 NGFR, RUNX2, APC 466 8 1 2 4 8 9 6 5
GO:0032332~positive regulation of 0.22222222 0.02877260 1352 10.8862660 0.13398310 40.9430 3 RELA, RUNX2, GLI3 466 8 1 chondrocyte differentiation 2 4 8 9 6 5
GO:0002837~regulation of immune 0.22222222 0.02877260 1352 10.8862660 0.13398310 40.9430 3 PVR, CRTAM, CD226 466 8 1 response to tumor cell 2 4 8 9 6 5 GO:0030857~negative regulation of 0.22222222 0.02877260 1352 10.8862660 0.13398310 40.9430 3 CAV1, TP63, ZEB1 466 8 1 epithelial cell differentiation 2 4 8 9 6 5
GO:0045346~regulation of MHC class II 0.22222222 0.02877260 1352 10.8862660 0.13398310 40.9430 3 CIITA, IFNG, IL10 466 8 1 biosynthetic process 2 4 8 9 6 5
GO:0048340~paraxial mesoderm 0.22222222 0.02877260 1352 10.8862660 0.13398310 40.9430 3 SMAD3, SMAD2, FOXC1 466 8 1 morphogenesis 2 4 8 9 6 5
GO:0045779~negative regulation of bone 0.22222222 0.02877260 1352 10.8862660 0.13398310 40.9430 3 P2RX7, VEGFA, INPP5D 466 8 1 resorption 2 4 8 9 6 5
GO:0002834~regulation of response to 0.22222222 0.02877260 1352 10.8862660 0.13398310 40.9430 3 PVR, CRTAM, CD226 466 8 1 tumor cell 2 4 8 9 6 5
GO:0046851~negative regulation of bone 0.22222222 0.02877260 1352 10.8862660 0.13398310 40.9430 3 P2RX7, VEGFA, INPP5D 466 8 1 remodeling 2 4 8 9 6 5
0.22222222 0.02877260 1352 10.8862660 0.13398310 40.9430 GO:0006301~postreplication repair 3 UBE2N, UBE2A, UBE2B 466 8 1 2 4 8 9 6 5
GO:0002052~positive regulation of 0.22222222 0.02877260 1352 10.8862660 0.13398310 40.9430 3 SMO, FOXG1, PAX6 466 8 1 neuroblast proliferation 2 4 8 9 6 5
GO:0002833~positive regulation of 0.22222222 0.02877260 1352 10.8862660 0.13398310 40.9430 3 PVR, CRTAM, CD226 466 8 1 response to biotic stimulus 2 4 8 9 6 5
GO:0048302~regulation of isotype 0.22222222 0.02877260 1352 10.8862660 0.13398310 40.9430 3 IFNG, CD40, IL2 466 8 1 switching to IgG isotypes 2 4 8 9 6 5
EGFR, SEC23A, SEC24B, TNF, FGF9,
TP53, TGFB3, PML, PAX6, NFKBIA, GO:0070727~cellular macromolecule 1.70370370 0.02898651 1352 1.61278016 0.13472027 41.1772 23 FGF10, GLI3, TGFB1, TGFB2, CBLB, 466 414 1 localization 4 6 8 2 9 6 NEDD4, TAP2, IFNG, SEC24C, SEC24D,
PRL, SEC61G, SEC61A2
GO:0055074~calcium ion homeostasis 13 0.96296296 0.02917147 CAV1, TGFB1, EDNRB, VDR, P2RX7, 466 188 1352 2.00739658 1 0.13532799 41.3790 3 CCR6, PTK2B, APOE, SAA1, CCR2, 8 5 4 6
RYR1, IL1B, IL2
EGFR, PVR, THRA, TNF, ICAM4,
1.25925925 0.02921796 ICAM3, CDH1, SOX9, VCAM1, NCAM1, 1352 1.78808235 41.4296 GO:0016337~cell-cell adhesion 17 466 276 1 0.13532893 9 6 PVRL1, CD44, CTGF, CD40LG, CD34, 8 4 8
ROR2, SYK
GO:0050848~regulation of 0.29629629 0.02978194 1352 5.80600858 0.13758415 42.0404 4 NCAM1, CD8A, TRAT1, SYK 466 20 1 calcium-mediated signaling 6 8 8 4 7 9
CAV1, ERBB2, TGFB1, VDR, EDNRB,
SAA1, APOE, PTK2B, ILK, CAMK2D, 0.03066251 1352 0.14119953 42.9821 GO:0048878~chemical homeostasis 27 2 IL1B, NEDD4L, MYC, IRS2, EGR2, TP53, 466 512 1.53088117 1 2 8 5 6 IRS1, STAT3, PTHLH, P2RX7, CCR6,
MT2A, CCR2, VEGFA, RYR1, IFI6, IL2
0.66666666 0.03102663 EGR2, PVRL1, ERBB2, EFNB1, FOXG1, 1352 2.44177931 0.14256387 GO:0007411~axon guidance 9 466 107 1 43.3673 7 5 PAX6, NGFR, GLI2, VASP 8 1 8
GO:0043010~camera-type eye 0.66666666 0.03102663 BMP4, CHD7, PVRL1, VEGFA, PAX6, 1352 2.44177931 0.14256387 9 466 107 1 43.3673 development 7 5 FOXC1, ZEB1, GLI3, APC 8 1 8
GO:0045137~development of primary 0.74074074 0.03105407 BMP4, CHD7, FGF9, VEGFA, STAT5B, 1352 2.28583015 0.14247151 43.3962 10 466 127 1 sexual characteristics 1 7 JAG2, ASB1, TP63, FOXC1, SOX9 8 1 2 3
GO:0045216~cell-cell junction 1352 4.14714898 0.14249814 43.4541 5 0.37037037 0.03110909 TGFB3, SMAD3, TGFB1, TGFB2, APC 466 35 1 organization 8 8 5 8
1352 4.14714898 0.14249814 43.4541 GO:0031016~pancreas development 5 0.37037037 0.03110909 IL6, FOXA2, SOX4, FGF10, SMAD2 466 35 1 8 8 5 8
GO:0031344~regulation of cell projection 0.59259259 0.03336373 TNFRSF12A, APOE, ILK, TGFB3, 1352 0.15193839 45.7814 8 466 89 2.60944206 1 organization 3 4 SMAD1, KIT, NGFR, APC 8 3 6
GO:0046849~bone remodeling 4 0.29629629 0.03388237 TNFSF11, IL7, TGFB3, TGFB1 466 21 1352 5.52953198 1 0.15392083 46.3038 6 3 8 4 9 5
SEC23A, SEC24B, TNF, FGF9, TP53,
TGFB3, PML, NFKBIA, FGF10, GLI3, GO:0006886~intracellular protein 1.55555555 1352 1.63002914 0.15449466 46.4923 21 0.03407069 TGFB1, TGFB2, CBLB, NEDD4, TAP2, 466 374 1 transport 6 8 8 8 5 IFNG, SEC24C, SEC24D, PRL, SEC61G,
SEC61A2
GO:0048168~regulation of neuronal 0.03407943 1352 4.03195040 0.15430679 5 0.37037037 EGR1, EGR2, APOE, KIT, CAMK2A 466 36 1 46.5011 synaptic plasticity 8 8 5 1
GO:0019218~regulation of steroid 0.03407943 1352 4.03195040 0.15430679 5 0.37037037 TNF, APOE, IFNG, STAT5B, NFKB1 466 36 1 46.5011 metabolic process 8 8 5 1
0.03407943 1352 4.03195040 0.15430679 GO:0001707~mesoderm formation 5 0.37037037 BMP4, SMAD3, SMAD2, FOXC1, SMAD1 466 36 1 46.5011 8 8 5 1
GO:0043407~negative regulation of MAP 0.03407943 1352 4.03195040 0.15430679 5 0.37037037 IRAK3, CAV1, APOE, IL1B, TP73 466 36 1 46.5011 kinase activity 8 8 5 1
0.44444444 1352 3.28641995 0.15747224 47.2980 GO:0030162~regulation of proteolysis 6 0.03488276 TNF, EP300, APOE, IFNG, IL1B, IL10 466 53 1 4 8 3 8 9
0.44444444 NOTCH1, EP300, RELA, ERBB2, RXRA, 1352 3.28641995 0.15747224 47.2980 GO:0001889~liver development 6 0.03488276 466 53 1 4 STAT5B 8 3 8 9
GO:0007204~elevation of cytosolic 0.66666666 0.03573497 EDNRB, P2RX7, CCR6, SAA1, PTK2B, 1352 0.16082373 48.1313 9 466 110 2.37518533 1 calcium ion concentration 7 1 CCR2, RYR1, IL1B, IL2 8 5 1
GO:0030947~regulation of vascular 0.22222222 0.03616383 1352 9.67668097 0.16238610 endothelial growth factor receptor 3 FGF9, VEGFA, FGF10 466 9 1 48.5459 2 4 8 3 5 signaling pathway
0.22222222 0.03616383 1352 9.67668097 0.16238610 GO:0035162~embryonic hemopoiesis 3 MLL, VEGFA, PBX1 466 9 1 48.5459 2 4 8 3 5
GO:0035019~somatic stem cell 3 0.22222222 0.03616383 NOG, KIT, APC 466 9 1352 9.67668097 1 0.16238610 48.5459 maintenance 2 4 8 3 5
GO:0045684~positive regulation of 0.22222222 0.03616383 1352 9.67668097 0.16238610 3 NOTCH1, TNF, TGFB2 466 9 1 48.5459 epidermis development 2 4 8 3 5
GO:0050691~regulation of defense 0.22222222 0.03616383 1352 9.67668097 0.16238610 3 MAVS, DDX58, PML 466 9 1 48.5459 response to virus by host 2 4 8 3 5
GO:0034405~response to fluid shear 0.22222222 0.03616383 1352 9.67668097 0.16238610 3 P2RX7, TGFB3, TGFB1 466 9 1 48.5459 stress 2 4 8 3 5
GO:0048009~insulin-like growth factor 0.22222222 0.03616383 1352 9.67668097 0.16238610 3 IGF1R, IRS1, GHR 466 9 1 48.5459 receptor signaling pathway 2 4 8 3 5
GO:0010574~regulation of vascular 0.22222222 0.03616383 1352 9.67668097 0.16238610 3 IL6, IL1B, IL1A 466 9 1 48.5459 endothelial growth factor production 2 4 8 3 5
GO:0032720~negative regulation of 0.22222222 0.03616383 1352 9.67668097 0.16238610 3 IRAK3, RARA, LBP 466 9 1 48.5459 tumor necrosis factor production 2 4 8 3 5
0.22222222 0.03616383 1352 9.67668097 0.16238610 GO:0033002~muscle cell proliferation 3 RXRA, FOXC1, TGFB2 466 9 1 48.5459 2 4 8 3 5
GO:0045671~negative regulation of 0.22222222 0.03616383 1352 9.67668097 0.16238610 3 TLR3, TLR4, INPP5D 466 9 1 48.5459 osteoclast differentiation 2 4 8 3 5
GO:0032673~regulation of interleukin-4 0.22222222 0.03616383 1352 9.67668097 0.16238610 3 RARA, IRF4, FOXP3 466 9 1 48.5459 production 2 4 8 3 5
CAV1, TGFB1, EDNRB, VDR, P2RX7, GO:0055066~di-, tri-valent inorganic 1.11111111 0.03679596 1352 1.82196922 0.16478836 49.1512 15 CCR6, PTK2B, APOE, SAA1, CCR2, 466 239 1 cation homeostasis 1 1 8 1 6 8 MT2A, RYR1, IL1B, MYC, IL2
GO:0043506~regulation of JUN kinase 0.03720909 1352 3.92297877 0.16626891 5 0.37037037 PTK2B, RIPK1, IL1B, TP73, SYK 466 37 1 49.5433 activity 9 8 3 9
GO:0009895~negative regulation of 0.03720909 1352 3.92297877 0.16626891 5 0.37037037 IRAK3, TNF, RELA, IL1B, IL10 466 37 1 49.5433 catabolic process 9 8 3 9 0.44444444 1352 3.22556032 0.16682046 49.7230 GO:0043279~response to alkaloid 6 0.03739955 PTK2B, RELA, RYR1, IL1B, MYC, GHR 466 54 1 4 8 4 7 5
0.44444444 IL6, TAP2, CAMK2G, TAP1, RAPGEF4, 1352 3.22556032 0.16682046 49.7230 GO:0015833~peptide transport 6 0.03739955 466 54 1 4 SMAD2 8 4 7 5
GO:0032387~negative regulation of 0.29629629 0.03825940 1352 5.27818962 0.17013503 50.5270 4 NFKBIE, NFKBIB, NFKBIA, IL10 466 22 1 intracellular transport 6 6 8 2 6 9
GO:0043525~positive regulation of 0.29629629 0.03825940 1352 5.27818962 0.17013503 50.5270 4 TNF, TP53, NQO1, TGFB2 466 22 1 neuron apoptosis 6 6 8 2 6 9
EGFR, EGR1, CAV1, TNF, EGR2, THRA,
GO:0044057~regulation of system 1.33333333 0.03857600 PTGS2, PTGS1, KIT, PARK2, IL10, 1352 1.69107046 0.17119629 50.8200 18 466 309 1 process 3 1 TGFB2, EDNRB, APOE, IFNG, IL1B, 8 1 9 7
CAMK2A, IL2
0.04049852 1352 3.81974248 0.17882393 52.5642 GO:0048332~mesoderm morphogenesis 5 0.37037037 BMP4, SMAD3, SMAD2, FOXC1, SMAD1 466 38 1 7 8 9 6 7
CUL3, MSX1, CHD7, HAND2, TGFB3, GO:0001701~in utero embryonic 0.88888888 1352 1.97932110 52.7633 12 0.04072218 TP53, CDH1, KEAP1, SMAD2, FOXC1, 466 176 1 0.17948215 development 9 8 8 4 TAB1, GLI3
GO:0042542~response to hydrogen 0.44444444 0.04275946 TXNIP, EP300, PTK2B, RELA, COL1A1, 1352 3.11036174 0.18747758 54.5407 6 466 56 1 peroxide 4 6 STAT1 8 1 7 2
GO:0045727~positive regulation of 0.29629629 0.04290944 1352 5.04870311 0.18781906 54.6690 4 IL6, TNF, PTK2B, CD28 466 23 1 translation 6 4 8 6 5 3
0.29629629 0.04290944 1352 5.04870311 0.18781906 54.6690 GO:0048806~genitalia development 4 CHD7, ASB1, ROR2, TP63 466 23 1 6 4 8 6 5 3
CAV1, EGR2, ERBB2, TP53, TGFB1, 0.04414611 1352 1.56151820 0.19251643 55.7141 GO:0050801~ion homeostasis 22 1.62962963 EDNRB, VDR, P2RX7, CCR6, SAA1, 466 409 1 9 8 1 1 3 APOE, PTK2B, MT2A, ILK, CCR2, RYR1, CAMK2D, IL1B, NEDD4L, MYC, IFI6,
IL2
0.22222222 0.04419419 1352 8.70901287 0.19244076 55.7542 GO:0002076~osteoblast development 3 PTHLH, SMAD3, GLI2 466 10 1 2 1 8 6 4 9
GO:0048567~ectodermal gut 0.22222222 0.04419419 1352 8.70901287 0.19244076 55.7542 3 NOTCH1, GLI2, GLI3 466 10 1 morphogenesis 2 1 8 6 4 9
GO:0021513~spinal cord dorsal/ventral 0.22222222 0.04419419 1352 8.70901287 0.19244076 55.7542 3 SMO, GLI2, GLI3 466 10 1 patterning 2 1 8 6 4 9
GO:0007439~ectodermal gut 0.22222222 0.04419419 1352 8.70901287 0.19244076 55.7542 3 NOTCH1, GLI2, GLI3 466 10 1 development 2 1 8 6 4 9
0.22222222 0.04419419 1352 8.70901287 0.19244076 55.7542 GO:0070227~lymphocyte apoptosis 3 IL2RA, FAS, MYC 466 10 1 2 1 8 6 4 9
0.22222222 0.04419419 1352 8.70901287 0.19244076 55.7542 GO:0050673~epithelial cell proliferation 3 BMP4, FGF10, KIT 466 10 1 2 1 8 6 4 9
GO:0033209~tumor necrosis 0.22222222 0.04419419 1352 8.70901287 0.19244076 55.7542 3 TNF, RIPK1, PYCARD 466 10 1 factor-mediated signaling pathway 2 1 8 6 4 9
GO:0050829~defense response to 0.22222222 0.04419419 1352 8.70901287 0.19244076 55.7542 3 IL6, TLR4, LBP 466 10 1 Gram-negative bacterium 2 1 8 6 4 9
GO:0050930~induction of positive 0.22222222 0.04419419 1352 8.70901287 0.19244076 55.7542 3 VEGFA, FGF10, AGER 466 10 1 chemotaxis 2 1 8 6 4 9
0.22222222 0.04419419 1352 8.70901287 0.19244076 55.7542 GO:0048535~lymph node development 3 TNFRSF11A, IL7R, TGFB1 466 10 1 2 1 8 6 4 9
GO:0050710~negative regulation of 0.22222222 0.04419419 1352 8.70901287 0.19244076 55.7542 3 TNF, FOXP3, IL10 466 10 1 cytokine secretion 2 1 8 6 4 9
GO:0032481~positive regulation of type I 0.22222222 0.04419419 1352 8.70901287 0.19244076 55.7542 3 MAVS, DDX58, TICAM1 466 10 1 interferon production 2 1 8 6 4 9 GO:0045687~positive regulation of glial 0.22222222 0.04419419 1352 8.70901287 0.19244076 55.7542 3 NOTCH1, BMP2, RELA 466 10 1 cell differentiation 2 1 8 6 4 9
GO:0034104~negative regulation of 0.22222222 0.04419419 1352 8.70901287 0.19244076 55.7542 3 P2RX7, VEGFA, INPP5D 466 10 1 tissue remodeling 2 1 8 6 4 9
GO:0030858~positive regulation of 0.22222222 0.04419419 1352 8.70901287 0.19244076 55.7542 3 NOTCH1, PAX6, APC 466 10 1 epithelial cell differentiation 2 1 8 6 4 9
MLL, THRA, TCOF1, TP53, NFKB1,
GO:0006351~transcription, 1.25925925 0.04512039 PAX3, STAT1, CBFB, IRF9, CDKN2A, 1352 1.69010523 0.19586278 56.5214 17 466 292 1 DNA-dependent 9 4 GATA3, PIR, IRF7, IRF1, IRF3, MYC, 8 8 5 1
NFATC1
0.44444444 0.04560384 PTK2B, TGFB3, SMAD3, TGFB1, TGFB2, 1352 3.05579399 0.19750989 56.9168 GO:0034330~cell junction organization 6 466 57 1 4 4 APC 8 1 1 1
GO:0003018~vascular process in 0.44444444 0.04855843 EDNRB, CAV1, ATG5, APOE, VEGFA, 1352 3.00310788 0.20886758 59.2604 6 466 58 1 circulatory system 4 3 FOXC1 8 8 2 6
0.74074074 0.04859432 EGFR, FOS, CDKN1A, UBE2A, NEDD4, 1352 2.10362629 0.20872223 59.2881 GO:0009416~response to light stimulus 10 466 138 1 1 7 RELA, PML, TP53, KIT, UBE2B 8 8 4 8
MLL, THRA, TCOF1, TP53, NFKB1,
1.25925925 0.04991048 PAX3, STAT1, CBFB, IRF9, CDKN2A, 1352 1.66726597 0.21356234 GO:0032774~RNA biosynthetic process 17 466 296 1 60.2923 9 9 GATA3, PIR, IRF7, IRF1, IRF3, MYC, 8 8 1
NFATC1
0.66666666 0.05057884 CRTAM, NOD1, TGFB3, TLR3, TLR4, 1352 2.21415581 0.21586162 60.7932 GO:0051606~detection of stimulus 9 466 118 1 7 9 NGFR, LBP, MYC, TLR8 8 6 4 1
GO:0010553~negative regulation of 0.05132526 1352 3.54024913 0.21844985 61.3455 specific transcription from RNA 5 0.37037037 CIITA, VDR, RXRA, SMAD3, NFKB1 466 41 1 9 8 6 3 5 polymerase II promoter
GO:0043473~pigmentation 6 0.44444444 0.05162350 EDNRB, KIT, PAX3, EDA, MYC, OCA2 466 59 1352 2.95220775 1 0.21930217 61.5641 4 8 8 4 1 9
0.44444444 0.05162350 1352 2.95220775 0.21930217 61.5641 GO:0007254~JNK cascade 6 WNT5A, CRKL, TNF, RIPK1, ROR2, SYK 466 59 1 4 8 8 4 1 9
0.59259259 0.05176981 CD44, TNFRSF12A, CTGF, PTK2B, 1352 2.36979942 0.21956831 61.6710 GO:0031589~cell-substrate adhesion 8 466 98 1 3 3 ITGB7, ILK, ITGB5, EDA 8 2 4 1
GO:0002526~acute inflammatory 0.59259259 0.05176981 IL6, SAA1, STAT5B, IL1B, TLR4, LBP, 1352 2.36979942 0.21956831 61.6710 8 466 98 1 response 3 3 STAT3, IL1A 8 2 4 1
CAV1, EGR2, ERBB2, TP53, TGFB1,
EDNRB, VDR, P2RX7, CCR6, SAA1, 1.77777777 0.05245689 1352 1.49510950 0.22190360 62.1689 GO:0019725~cellular homeostasis 24 APOE, PTK2B, MT2A, ILK, TXN, CCR2, 466 466 1 8 4 8 7 8 5 RYR1, CAMK2D, IL1B, NEDD4L, MYC,
IFI6, IL2, APC
KIF23, E2F1, STK11, CAMK2G, PML,
CDC34, TGFB1, TGFB2, CUL3, CDKN2A,
2.07407407 0.05246985 IFNG, ILK, CAMK2D, CAMK2B, MYC, 1352 1.43865699 0.22165545 62.1782 GO:0022402~cell cycle process 28 466 565 1 4 6 CAMK2A, NFATC1, APC, EGFR, TP53, 8 4 5 9
SMAD3, UBR2, RB1, TP73, CDKN1C,
CDKN1A, CDKN1B, IRF6
0.22222222 0.05281120 1352 7.91728443 0.22265987 62.4233 GO:0021871~forebrain regionalization 3 BMP4, PAX6, GLI3 466 11 1 2 4 8 2 2 3
GO:0042517~positive regulation of 0.22222222 0.05281120 1352 7.91728443 0.22265987 62.4233 3 GH1, IL6, GHR 466 11 1 tyrosine phosphorylation of Stat3 protein 2 4 8 2 2 3
GO:0010812~negative regulation of 0.22222222 0.05281120 1352 7.91728443 0.22265987 62.4233 3 CDKN2A, COL1A1, PTEN 466 11 1 cell-substrate adhesion 2 4 8 2 2 3
GO:0002244~hemopoietic progenitor cell 0.22222222 0.05281120 1352 7.91728443 0.22265987 62.4233 3 PRKDC, SOX4, KIT 466 11 1 differentiation 2 4 8 2 2 3 GO:0032370~positive regulation of lipid 0.22222222 0.05281120 1352 7.91728443 0.22265987 62.4233 3 P2RX7, APOE, NFKBIA 466 11 1 transport 2 4 8 2 2 3
GO:0008593~regulation of Notch 0.22222222 0.05281120 1352 7.91728443 0.22265987 62.4233 3 NFKBIA, TP63, KIT 466 11 1 signaling pathway 2 4 8 2 2 3
0.22222222 0.05281120 1352 7.91728443 0.22265987 62.4233 GO:0043586~tongue development 3 EGFR, BMP4, ERBB2 466 11 1 2 4 8 2 2 3
0.22222222 0.05281120 1352 7.91728443 0.22265987 62.4233 GO:0030238~male sex determination 3 IGF1R, FGF9, SOX9 466 11 1 2 4 8 2 2 3
GO:0045661~regulation of myoblast 0.22222222 0.05281120 1352 7.91728443 0.22265987 62.4233 3 BMP4, NOTCH1, ILK 466 11 1 differentiation 2 4 8 2 2 3
GO:0014015~positive regulation of 0.22222222 0.05281120 1352 7.91728443 0.22265987 62.4233 3 NOTCH1, BMP2, RELA 466 11 1 gliogenesis 2 4 8 2 2 3
GO:0050810~regulation of steroid 0.29629629 0.05301036 1352 4.64480686 0.22311988 62.5656 4 TNF, APOE, IFNG, NFKB1 466 25 1 biosynthetic process 6 6 8 7 3 1
GO:0051785~positive regulation of 0.29629629 0.05301036 1352 4.64480686 0.22311988 62.5656 4 TNF, IL1B, IL1A, CD28 466 25 1 nuclear division 6 6 8 7 3 1
GO:0046637~regulation of alpha-beta T 0.29629629 0.05301036 1352 4.64480686 0.22311988 62.5656 4 RARA, IL2RG, IRF4, SYK 466 25 1 cell differentiation 6 6 8 7 3 1
GO:0040018~positive regulation of 0.29629629 0.05301036 1352 4.64480686 0.22311988 62.5656 4 GH1, CHD7, STAT5B, GHR 466 25 1 multicellular organism growth 6 6 8 7 3 1
GO:0045840~positive regulation of 0.29629629 0.05301036 1352 4.64480686 0.22311988 62.5656 4 TNF, IL1B, IL1A, CD28 466 25 1 mitosis 6 6 8 7 3 1
0.29629629 0.05301036 1352 4.64480686 0.22311988 62.5656 GO:0019827~stem cell maintenance 4 NOG, CREBBP, KIT, APC 466 25 1 6 6 8 7 3 1
0.51851851 IL6, CCR6, TNF, IL7, PDCD1, BLNK, 1352 2.57228228 0.22732879 63.4046 GO:0006959~humoral immune response 7 0.05419955 466 79 1 9 CD28 8 4 9 3 GO:0009743~response to carbohydrate 0.44444444 0.05479920 TXNIP, PTGS2, PTK2B, SMAD2, PTEN, 1352 2.90300429 0.22928896 63.8209 6 466 60 1 stimulus 4 3 TGFB1 8 2 5 3
GO:0007368~determination of left/right 0.05525213 1352 0.23068854 64.1324 5 0.37037037 SMO, NOTCH1, FGF10, TBX1, PITX2 466 42 3.45595749 1 symmetry 6 8 9 1
0.05525213 1352 0.23068854 64.1324 GO:0051591~response to cAMP 5 0.37037037 FOS, PTK2B, RELA, COL1A1, STAT1 466 42 3.45595749 1 6 8 9 1
0.44444444 0.05808552 FGFR2, FGFR1, TGFB3, IL7R, TGFB1, 1352 2.85541405 0.24096056 66.0241 GO:0016049~cell growth 6 466 61 1 4 1 TGFB2 8 8 7 7
IRAK3, CAV1, CDKN2A, ATG5, RELA, GO:0051248~negative regulation of 0.88888888 0.05824930 1352 1.86289045 66.1305 12 SOCS1, PML, NFKB1, FOXP3, IL10, 466 187 1 0.2412521 protein metabolic process 9 6 8 5 9 TGFB1, IL2
GO:0050994~regulation of lipid catabolic 0.29629629 0.05845051 1352 4.46616044 0.24168122 66.2608 4 IRS2, TNF, IL1B, IRS1 466 26 1 process 6 9 8 9 1 9
GO:0046635~positive regulation of 0.29629629 0.05845051 1352 4.46616044 0.24168122 66.2608 4 RIPK2, RARA, IL2RG, SYK 466 26 1 alpha-beta T cell activation 6 9 8 9 1 9
0.29629629 0.05845051 1352 4.46616044 0.24168122 66.2608 GO:0031100~organ regeneration 4 CDKN1A, SOCS3, SOCS1, TGFB1 466 26 1 6 9 8 9 1 9
GO:0048066~pigmentation during 0.29629629 0.05845051 1352 4.46616044 0.24168122 66.2608 4 EDNRB, KIT, PAX3, OCA2 466 26 1 development 6 9 8 9 1 9
GO:0035303~regulation of 0.29629629 0.05845051 1352 4.46616044 0.24168122 66.2608 4 IFNG, SMAD3, TGFB1, TGFB2 466 26 1 dephosphorylation 6 9 8 9 1 9
0.29629629 0.05845051 1352 4.46616044 0.24168122 66.2608 GO:0048864~stem cell development 4 NOG, CREBBP, KIT, APC 466 26 1 6 9 8 9 1 9
0.59259259 0.05908789 BMP4, PTK2B, SMAD5, ZBTB16, KIT, 1352 0.24371820 66.6705 GO:0007281~germ cell development 8 466 101 2.29940934 1 3 1 UBE2B, OCA2, AXIN1 8 1 5
GO:0009799~determination of symmetry 5 0.37037037 0.05933651 SMO, NOTCH1, FGF10, TBX1, PITX2 466 43 1352 3.37558638 1 0.24431603 66.8290 8 6 3 6
GO:0009855~determination of bilateral 1352 3.37558638 0.24431603 66.8290 5 0.37037037 0.05933651 SMO, NOTCH1, FGF10, TBX1, PITX2 466 43 1 symmetry 8 6 3 6
GO:0007162~negative regulation of cell 1352 3.37558638 0.24431603 66.8290 5 0.37037037 0.05933651 CDKN2A, SIPA1, COL1A1, PTEN, TGFB1 466 43 1 adhesion 8 6 3 6
MLL, THRA, NFKB1, PAX3, STAT1, GO:0006366~transcription from RNA 1.03703703 0.06083447 1352 1.73684017 0.24948803 67.7691 14 CBFB, IRF9, PIR, IRF7, GATA3, IRF1, 466 234 1 polymerase II promoter 7 6 8 5 8 7 IRF3, MYC, NFATC1
0.22222222 0.06196524 1352 0.25328427 68.4620 GO:0001958~endochondral ossification 3 PTHLH, COL1A1, RUNX2 466 12 7.25751073 1 2 2 8 4 9
GO:0048339~paraxial mesoderm 0.22222222 0.06196524 1352 0.25328427 68.4620 3 SMAD3, SMAD2, FOXC1 466 12 7.25751073 1 development 2 2 8 4 9
GO:0060389~pathway-restricted SMAD 0.22222222 0.06196524 1352 0.25328427 68.4620 3 BMP2, TGFB1, TGFB2 466 12 7.25751073 1 protein phosphorylation 2 2 8 4 9
GO:0031116~positive regulation of 0.22222222 0.06196524 1352 0.25328427 68.4620 3 CAV1, CDKN1B, APC 466 12 7.25751073 1 microtubule polymerization 2 2 8 4 9
0.22222222 0.06196524 1352 0.25328427 68.4620 GO:0021511~spinal cord patterning 3 SMO, GLI2, GLI3 466 12 7.25751073 1 2 2 8 4 9
GO:0035196~gene silencing by miRNA, 0.22222222 0.06196524 1352 0.25328427 68.4620 3 SMAD3, SMAD2, SMAD1 466 12 7.25751073 1 production of miRNAs 2 2 8 4 9
GO:0048593~camera-type eye 0.06357711 1352 3.29886851 0.25879266 69.4255 5 0.37037037 BMP4, PVRL1, VEGFA, ZEB1, GLI3 466 44 1 morphogenesis 1 8 3 9 5
GO:0001952~regulation of cell-matrix 0.29629629 0.06414235 1352 4.30074709 0.26049674 69.7567 4 CDKN2A, ILK, SMAD3, PTEN 466 27 1 adhesion 6 9 8 9 2 7
GO:0031098~stress-activated protein 0.44444444 0.06498935 1352 2.76476599 0.26320279 70.2467 6 WNT5A, CRKL, TNF, RIPK1, ROR2, SYK 466 63 1 kinase signaling pathway 4 9 8 2 4 7 GO:0010243~response to organic 0.44444444 0.06498935 CDKN1A, PTGS2, PTK2B, RELA, PTGS1, 1352 2.76476599 0.26320279 70.2467 6 466 63 1 nitrogen 4 9 SMAD1 8 2 4 7
EGFR, MRC1, SEC23A, CAV1, LRSAM1,
1.48148148 0.06591203 SEC24B, HCK, MRC2, LMNA, TP53, 1352 1.52388676 GO:0016044~membrane organization 20 466 381 1 0.26616355 70.772 1 7 P2RX7, APOE, NEDD4, ATG7, LRP6, 8 7
LBP, SEC24C, SEC24D, CD14, GHR
GO:0051969~regulation of transmission 0.74074074 0.06706277 EGFR, EGR1, TNF, EGR2, PTGS2, APOE, 1352 1.97483285 0.26991607 71.4147 10 466 147 1 of nerve impulse 1 7 IFNG, KIT, PARK2, CAMK2A 8 2 5 9
GO:0051832~avoidance of defenses of 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 other organism during symbiotic 2 SMAD3, TGFB1 466 2 1 8 4 8 2 4 5 interaction
0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 GO:0044413~avoidance of host defenses 2 SMAD3, TGFB1 466 2 1 8 4 8 2 4 5
GO:0043932~ossification involved in 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 2 TGFB3, TGFB1 466 2 1 bone remodeling 8 4 8 2 4 5
GO:0060364~frontal suture 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 2 TGFB3, TGFB1 466 2 1 morphogenesis 8 4 8 2 4 5
GO:0048296~regulation of isotype 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 2 TNFSF12, TGFB1 466 2 1 switching to IgA isotypes 8 4 8 2 4 5
GO:0034142~toll-like receptor 4 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 2 NFKBIA, RIPK2 466 2 1 signaling pathway 8 4 8 2 4 5
GO:0034134~toll-like receptor 2 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 2 IRAK1, RIPK2 466 2 1 signaling pathway 8 4 8 2 4 5
GO:0042977~activation of JAK2 kinase 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 2 PRLR, GHR 466 2 1 activity 8 4 8 2 4 5
GO:0046136~positive regulation of 2 0.14814814 0.06756724 TNF, IFNG 466 2 1352 29.0300429 1 0.27136081 71.6923 vitamin metabolic process 8 4 8 2 4 5
GO:0044415~evasion or tolerance of host 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 2 SMAD3, TGFB1 466 2 1 defenses 8 4 8 2 4 5
GO:0033084~regulation of immature T 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 2 CDKN2A, ERBB2 466 2 1 cell proliferation in the thymus 8 4 8 2 4 5
GO:0031063~regulation of histone 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 2 PML, FOXP3 466 2 1 deacetylation 8 4 8 2 4 5
GO:0033088~negative regulation of 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 immature T cell proliferation in the 2 CDKN2A, ERBB2 466 2 1 8 4 8 2 4 5 thymus
GO:0042094~interleukin-2 biosynthetic 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 2 IL18, PAWR 466 2 1 process 8 4 8 2 4 5
GO:0060557~positive regulation of 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 2 TNF, IFNG 466 2 1 vitamin D biosynthetic process 8 4 8 2 4 5
GO:0070427~nucleotide-binding 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 oligomerization domain containing 1 2 NFKBIA, RIPK2 466 2 1 8 4 8 2 4 5 signaling pathway
GO:0048298~positive regulation of 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 2 TNFSF12, TGFB1 466 2 1 isotype switching to IgA isotypes 8 4 8 2 4 5
GO:0051834~evasion or tolerance of 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 defenses of other organism during 2 SMAD3, TGFB1 466 2 1 8 4 8 2 4 5 symbiotic interaction
GO:0002439~chronic inflammatory 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 2 TNF, IL1B 466 2 1 response to antigenic stimulus 8 4 8 2 4 5
GO:0060363~cranial suture 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 2 TGFB3, TGFB1 466 2 1 morphogenesis 8 4 8 2 4 5 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 GO:0009597~detection of virus 2 TLR3, TLR8 466 2 1 8 4 8 2 4 5
0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 GO:0009602~detection of symbiont 2 TLR3, TLR8 466 2 1 8 4 8 2 4 5
GO:0021776~smoothened signaling 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 pathway involved in spinal cord motor 2 GLI2, GLI3 466 2 1 8 4 8 2 4 5 neuron cell fate specification
GO:0009814~defense response, 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 2 TNFRSF1A, TGFB1 466 2 1 incompatible interaction 8 4 8 2 4 5
GO:0019049~evasion of host defenses by 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 2 SMAD3, TGFB1 466 2 1 virus 8 4 8 2 4 5
GO:0033087~negative regulation of 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 2 CDKN2A, ERBB2 466 2 1 immature T cell proliferation 8 4 8 2 4 5
GO:0045066~regulatory T cell 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 2 TGFB1, CD28 466 2 1 differentiation 8 4 8 2 4 5
GO:0034116~positive regulation of 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 2 TNF, IL1B 466 2 1 heterotypic cell-cell adhesion 8 4 8 2 4 5
GO:0021775~smoothened signaling 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 pathway involved in ventral spinal cord 2 GLI2, GLI3 466 2 1 8 4 8 2 4 5 interneuron specification
GO:0010766~negative regulation of 0.14814814 0.06756724 1352 29.0300429 0.27136081 71.6923 2 NEDD4, NEDD4L 466 2 1 sodium ion transport 8 4 8 2 4 5
GO:0051495~positive regulation of 1352 3.22556032 0.27244919 71.9134 5 0.37037037 0.06797241 CAV1, P2RX7, CDKN1B, SMAD3, APC 466 45 1 cytoskeleton organization 8 4 8 3
GO:0009749~response to glucose 1352 3.22556032 0.27244919 71.9134 5 0.37037037 0.06797241 TXNIP, PTK2B, SMAD2, PTEN, TGFB1 466 45 1 stimulus 8 4 8 3 GO:0050768~negative regulation of 1352 3.22556032 0.27244919 71.9134 5 0.37037037 0.06797241 BMP4, NOG, TP53, NGFR, TGFB1 466 45 1 neurogenesis 8 4 8 3
GO:0048167~regulation of synaptic 0.44444444 0.06860622 EGR1, EGR2, PTGS2, APOE, KIT, 1352 2.72156652 0.27433745 6 466 64 1 72.256 plasticity 4 3 CAMK2A 8 4 4
GO:0048608~reproductive structure 0.66666666 0.06892152 BMP4, NOG, FGF9, VEGFA, STAT5B, 1352 2.07357449 0.27510025 72.4249 9 466 126 1 development 7 8 JAG2, TP63, FOXC1, SOX9 8 4 7 5
0.29629629 0.07007919 1352 4.14714898 0.27880387 73.0369 GO:0007159~leukocyte adhesion 4 VCAM1, TNF, CD40LG, SYK 466 28 1 6 1 8 8 1 5
GO:0007173~epidermal growth factor 0.29629629 0.07007919 1352 4.14714898 0.27880387 73.0369 4 EGFR, PTK2B, CBL, TGFB1 466 28 1 receptor signaling pathway 6 1 8 8 1 5
GO:0021983~pituitary gland 0.29629629 0.07007919 1352 4.14714898 0.27880387 73.0369 4 BMP4, PAX6, CDH1, GLI2 466 28 1 development 6 1 8 8 1 5
GO:0045833~negative regulation of lipid 0.29629629 0.07007919 1352 4.14714898 0.27880387 73.0369 4 TNF, APOE, IL1B, NFKB1 466 28 1 metabolic process 6 1 8 8 1 5
0.29629629 0.07007919 1352 4.14714898 0.27880387 73.0369 GO:0050821~protein stabilization 4 PML, IFI30, SOX4, UBE2B 466 28 1 6 1 8 8 1 5
0.29629629 0.07007919 1352 4.14714898 0.27880387 73.0369 GO:0035051~cardiac cell differentiation 4 BMP2, ATG5, RXRA, TGFB2 466 28 1 6 1 8 8 1 5
GO:0031112~positive regulation of 0.22222222 0.07160938 1352 6.69924067 73.8262 microtubule polymerization or 3 CAV1, CDKN1B, APC 466 13 1 0.28377458 2 1 8 3 2 depolymerization
0.22222222 0.07160938 1352 6.69924067 73.8262 GO:0042474~middle ear morphogenesis 3 NOG, TBX1, MYC 466 13 1 0.28377458 2 1 8 3 2
0.22222222 0.07160938 1352 6.69924067 73.8262 GO:0048820~hair follicle maturation 3 NOTCH1, PTGS2, TGFB2 466 13 1 0.28377458 2 1 8 3 2
GO:0031050~dsRNA fragmentation 3 0.22222222 0.07160938 SMAD3, SMAD2, SMAD1 466 13 1352 6.69924067 1 0.28377458 73.8262 2 1 8 3 2
GO:0031113~regulation of microtubule 0.22222222 0.07160938 1352 6.69924067 73.8262 3 CAV1, CDKN1B, APC 466 13 1 0.28377458 polymerization 2 1 8 3 2
0.22222222 0.07160938 1352 6.69924067 73.8262 GO:0001759~induction of an organ 3 BMP4, SIX1, FGF10 466 13 1 0.28377458 2 1 8 3 2
GO:0050996~positive regulation of lipid 0.22222222 0.07160938 1352 6.69924067 73.8262 3 IRS2, IL1B, IRS1 466 13 1 0.28377458 catabolic process 2 1 8 3 2
GO:0045907~positive regulation of 0.22222222 0.07160938 1352 6.69924067 73.8262 3 CAV1, PTGS2, PTGS1 466 13 1 0.28377458 vasoconstriction 2 1 8 3 2
GO:0010810~regulation of cell-substrate 0.07252064 1352 3.15543944 0.28657232 74.2858 5 0.37037037 CDKN2A, ILK, SMAD3, COL1A1, PTEN 466 46 1 adhesion 5 8 8 9 2
GO:0060249~anatomical structure 0.59259259 0.07263399 PTHLH, P2RX7, TNFSF11, IL7, VEGFA, 1352 2.19094663 0.28660909 74.3424 8 466 106 1 homeostasis 3 4 PRKDC, FBXO4, APC 8 5 4 5
GO:0051789~response to protein 0.59259259 EGR1, FOS, P2RX7, MSX1, IFNG, FAS, 1352 2.17047049 0.29622600 75.7578 8 0.07554651 466 107 1 stimulus 3 EIF2AK2, TGFB1 8 9 5 7
GO:0045807~positive regulation of 0.29629629 0.07625390 1352 4.00414385 0.29826682 76.0903 4 CAV1, CBL, FGF10, NEDD4L 466 29 1 endocytosis 6 3 8 1 8 4
GO:0048638~regulation of 0.07721982 1352 3.08830243 0.30117107 76.5373 5 0.37037037 NOG, FGF9, TNFRSF12A, APOE, ILK 466 47 1 developmental growth 7 8 8 7 7
0.51851851 0.07877799 BMP4, SMO, NOTCH1, PTGS2, FGF10, 1352 0.30604690 77.2418 GO:0048589~developmental growth 7 466 87 2.33575058 1 9 2 GLI2, GLI3 8 7 8
WNT5A, CAV1, TNF, PML, TP63,
PRKDC, SFN, FOS, ATG5, IFNG, FBXO6, 1352 1.38482536 0.31402403 78.3317 GO:0033554~cellular response to stress 27 2 0.08128053 SYK, APC, UBE2A, RXRA, TP53, 466 566 1 8 9 2 3 UBE2B, TP73, UBE2N, SMO, CDKN1A,
CRKL, NEDD4, RIPK1, IRF7, ROR2, EIF2AK2
GO:0045069~regulation of viral genome 0.22222222 0.08169927 1352 6.22072348 0.31503534 3 TNF, TNIP1, CD28 466 14 1 78.5092 replication 2 5 8 3 2
GO:0030279~negative regulation of 0.22222222 0.08169927 1352 6.22072348 0.31503534 3 PTK2B, SOX9, TGFB1 466 14 1 78.5092 ossification 2 5 8 3 2
GO:0046632~alpha-beta T cell 0.22222222 0.08169927 1352 6.22072348 0.31503534 3 RELB, IRF1, SYK 466 14 1 78.5092 differentiation 2 5 8 3 2
GO:0002028~regulation of sodium ion 0.22222222 0.08169927 1352 6.22072348 0.31503534 3 P2RX7, NEDD4, NEDD4L 466 14 1 78.5092 transport 2 5 8 3 2
0.22222222 0.08169927 1352 6.22072348 0.31503534 GO:0048844~artery morphogenesis 3 APOE, TBX1, FOXC1 466 14 1 78.5092 2 5 8 3 2
GO:0045604~regulation of epidermal cell 0.22222222 0.08169927 1352 6.22072348 0.31503534 3 NOTCH1, TP63, KEAP1 466 14 1 78.5092 differentiation 2 5 8 3 2
GO:0045940~positive regulation of 0.22222222 0.08169927 1352 6.22072348 0.31503534 3 TNF, APOE, IFNG 466 14 1 78.5092 steroid metabolic process 2 5 8 3 2
GO:0010721~negative regulation of cell 0.08206775 1352 3.02396280 0.31587681 78.6642 5 0.37037037 BMP4, NOG, TP53, NGFR, TGFB1 466 48 1 development 7 8 4 2 4
0.08206775 1352 3.02396280 0.31587681 78.6642 GO:0035282~segmentation 5 0.37037037 EP300, EGR2, MEOX2, PRKDC, ROR2 466 48 1 7 8 4 2 4
GO:0030178~negative regulation of Wnt 0.29629629 0.08265901 1352 3.87067238 0.31744936 4 FGF9, LRP6, AXIN1, APC 466 30 1 78.9108 receptor signaling pathway 6 8 8 9 9
GO:0002377~immunoglobulin 0.29629629 0.08265901 1352 3.87067238 0.31744936 4 CD40LG, PRKDC, FAS, IL7R 466 30 1 78.9108 production 6 8 8 9 9
0.29629629 0.08265901 1352 3.87067238 0.31744936 GO:0009798~axis specification 4 PAX6, SMAD2, AXIN1, APC 466 30 1 78.9108 6 8 8 9 9
GO:0046620~regulation of organ growth 4 0.29629629 0.08265901 NOG, IL7, FGF9, FOXC1 466 30 1352 3.87067238 1 0.31744936 78.9108 6 8 8 9 9
0.51851851 0.08575972 CD44, CTGF, PTK2B, ITGB7, ILK, 1352 2.28326180 0.32721630 80.1603 GO:0007160~cell-matrix adhesion 7 466 89 1 9 4 ITGB5, EDA 8 3 3 8
GO:0046545~development of primary 0.44444444 0.08831572 BMP4, CHD7, VEGFA, STAT5B, TP63, 1352 2.52435155 0.33509781 81.1375 6 466 69 1 female sexual characteristics 4 7 FOXC1 8 8 4 1
0.44444444 0.08831572 BMP4, CHD7, VEGFA, STAT5B, TP63, 1352 2.52435155 0.33509781 81.1375 GO:0046660~female sex differentiation 6 466 69 1 4 7 FOXC1 8 8 4 1
PVR, THRA, TNF, TNFRSF12A, ITGB5,
KITLG, CDH1, SOX9, VCAM1, CD96,
PVRL1, CD44, CTGF, PTK2B, ITGB7, 0.08873419 1352 1.32519454 0.33605046 81.2930 GO:0022610~biological adhesion 32 2.37037037 ILK, PSTPIP1, SYK, APC, EGFR, ICAM4, 466 701 1 8 8 1 2 9 INPPL1, EFNB1, ICAM3, NCAM1, CD34,
CD40LG, ROR2, MADCAM1, EDA,
CD226, IL2
GO:0002440~production of molecular 0.29629629 0.08928675 1352 3.74581198 0.33742905 81.4966 4 CD40LG, PRKDC, FAS, IL7R 466 31 1 mediator of immune response 6 3 8 9 7 7
PVR, THRA, TNF, TNFRSF12A, ITGB5,
KITLG, CDH1, SOX9, VCAM1, CD96,
PVRL1, CD44, CTGF, PTK2B, ITGB7, 0.09012658 1352 1.32708767 0.33971859 81.8020 GO:0007155~cell adhesion 32 2.37037037 ILK, PSTPIP1, SYK, APC, EGFR, ICAM4, 466 700 1 8 8 6 6 8 INPPL1, EFNB1, ICAM3, NCAM1, CD34,
CD40LG, ROR2, MADCAM1, EDA,
CD226, IL2
IL6, FGF10, PARK2, IL10, TGFB2, 1.11111111 1352 1.58923592 0.34190491 82.0925 GO:0007626~locomotory behavior 15 0.09093771 EDNRB, CCR6, CHD7, DEFA1B, SAA1, 466 274 1 1 8 6 5 3 IFNG, CCR2, IL1B, DEFA1, PTAFR, SYK GO:0043370~regulation of CD4-positive, 0.22222222 0.09219303 1352 5.80600858 0.34548464 82.5334 3 RARA, IL2RG, IRF4 466 15 1 alpha beta T cell differentiation 2 5 8 4 7 1
0.22222222 0.09219303 1352 5.80600858 0.34548464 82.5334 GO:0048665~neuron fate specification 3 FOXA2, GLI2, GLI3 466 15 1 2 5 8 4 7 1
GO:0045806~negative regulation of 0.22222222 0.09219303 1352 5.80600858 0.34548464 82.5334 3 LRSAM1, PTEN, TGFB1 466 15 1 endocytosis 2 5 8 4 7 1
GO:0042771~DNA damage response, 0.22222222 0.09219303 1352 5.80600858 0.34548464 82.5334 signal transduction by p53 class mediator 3 PML, TP53, TP63 466 15 1 2 5 8 4 7 1 resulting in induction of apoptosis
0.22222222 0.09219303 1352 5.80600858 0.34548464 82.5334 GO:0006020~inositol metabolic process 3 INPPL1, PTEN, PTAFR 466 15 1 2 5 8 4 7 1
GO:0007229~integrin-mediated signaling 0.44444444 0.09257657 1352 2.48828939 0.34629641 82.6660 6 GAB2, CTGF, ITGB7, ILK, ITGB5, SYK 466 70 1 pathway 4 1 8 3 3 6
0.51851851 0.09307111 CDKN2A, FBXO6, PML, TP53, RB1, 1352 2.23308022 0.34745444 82.8356 GO:0000075~cell cycle checkpoint 7 466 91 1 9 7 TGFB1, APC 8 4 9 9
0.29629629 0.09612906 1352 3.62875536 0.35660777 83.8502 GO:0048863~stem cell differentiation 4 NOG, CREBBP, KIT, APC 466 32 1 6 1 8 5 3 7
0.29629629 0.09612906 1352 3.62875536 0.35660777 83.8502 GO:0030168~platelet activation 4 IL6, CD40LG, SAA1, CD40 466 32 1 6 1 8 5 3 7
GO:0001933~negative regulation of 0.29629629 0.09612906 1352 3.62875536 0.35660777 83.8502 4 CAV1, SOCS1, TGFB1, IL2 466 32 1 protein amino acid phosphorylation 6 1 8 5 3 7
GO:0043507~positive regulation of JUN 0.29629629 0.09612906 1352 3.62875536 0.35660777 83.8502 4 PTK2B, RIPK1, IL1B, SYK 466 32 1 kinase activity 6 1 8 5 3 7
GO:0001936~regulation of endothelial 0.29629629 0.09612906 1352 3.62875536 0.35660777 83.8502 4 CAV1, APOE, VEGFA, TNFSF12 466 32 1 cell proliferation 6 1 8 5 3 7
GO:0050804~regulation of synaptic 9 0.66666666 0.09692483 EGFR, EGR1, TNF, EGR2, PTGS2, APOE, 466 136 1352 1.92110578 1 0.35866830 84.1048 transmission 7 4 KIT, PARK2, CAMK2A 8 1 3 5
GO:0046449~creatinine metabolic 0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 2 STAT5B, GHR 466 3 1 process 8 6 8 5 4 1
GO:0002238~response to molecule of 0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 2 MYD88, TLR2 466 3 1 fungal origin 8 6 8 5 4 1
GO:0050705~regulation of interleukin-1 0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 2 P2RX7, PANX1 466 3 1 alpha secretion 8 6 8 5 4 1
GO:0050765~negative regulation of 0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 2 PTEN, TGFB1 466 3 1 phagocytosis 8 6 8 5 4 1
GO:0060317~cardiac epithelial to 0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 2 BMP2, TGFB2 466 3 1 mesenchymal transition 8 6 8 5 4 1
GO:0034121~regulation of toll-like 0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 2 IRAK3, LBP 466 3 1 receptor signaling pathway 8 6 8 5 4 1
0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 GO:0030730~sequestering of triglyceride 2 TNF, IL1B 466 3 1 8 6 8 5 4 1
0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 GO:0010470~regulation of gastrulation 2 TNF, IL1B 466 3 1 8 6 8 5 4 1
0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 GO:0032623~interleukin-2 production 2 IL18, PAWR 466 3 1 8 6 8 5 4 1
GO:0046013~regulation of T cell 0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 2 IL2RA, IL2 466 3 1 homeostatic proliferation 8 6 8 5 4 1
0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 GO:0048570~notochord morphogenesis 2 NOG, GLI2 466 3 1 8 6 8 5 4 1
0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 GO:0060553~induction of necroptosis 2 TNF, RIPK1 466 3 1 8 6 8 5 4 1
GO:0033028~myeloid cell apoptosis 2 0.14814814 0.09962263 IL6, IFNG 466 3 1352 19.3533619 1 0.36656127 84.9400 8 6 8 5 4 1
GO:0018076~N-terminal peptidyl-lysine 0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 2 EP300, CREBBP 466 3 1 acetylation 8 6 8 5 4 1
GO:0032966~negative regulation of 0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 2 CIITA, IL6 466 3 1 collagen biosynthetic process 8 6 8 5 4 1
GO:0060545~positive regulation of 0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 2 TNF, RIPK1 466 3 1 necroptosis 8 6 8 5 4 1
GO:0070587~regulation of cell-cell 0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 2 TNF, IL1B 466 3 1 adhesion involved in gastrulation 8 6 8 5 4 1
GO:0010692~regulation of alkaline 0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 2 SMAD3, TGFB2 466 3 1 phosphatase activity 8 6 8 5 4 1
0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 GO:0006925~inflammatory cell apoptosis 2 IFNG, FAS 466 3 1 8 6 8 5 4 1
GO:0032727~positive regulation of 0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 2 MAVS, DDX58 466 3 1 interferon-alpha production 8 6 8 5 4 1
GO:0010800~positive regulation of 0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 2 TGFB1, AXIN1 466 3 1 peptidyl-threonine phosphorylation 8 6 8 5 4 1
GO:0070102~interleukin-6-mediated 0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 2 IL6, STAT3 466 3 1 signaling pathway 8 6 8 5 4 1
GO:0050717~positive regulation of 0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 2 P2RX7, PANX1 466 3 1 interleukin-1 alpha secretion 8 6 8 5 4 1
0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 GO:0001781~neutrophil apoptosis 2 IL6, IFNG 466 3 1 8 6 8 5 4 1
GO:0034114~regulation of heterotypic 0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 2 TNF, IL1B 466 3 1 cell-cell adhesion 8 6 8 5 4 1
GO:0035234~germ cell programmed cell 2 0.14814814 0.09962263 PRKDC, KIT 466 3 1352 19.3533619 1 0.36656127 84.9400 death 8 6 8 5 4 1
0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 GO:0018394~peptidyl-lysine acetylation 2 EP300, CREBBP 466 3 1 8 6 8 5 4 1
0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 GO:0060544~regulation of necroptosis 2 TNF, RIPK1 466 3 1 8 6 8 5 4 1
GO:0032656~regulation of interleukin-13 0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 2 RARA, IRF4 466 3 1 production 8 6 8 5 4 1
GO:0060555~induction of necroptosis by 0.14814814 0.09962263 1352 19.3533619 0.36656127 84.9400 2 TNF, RIPK1 466 3 1 extracellular signals 8 6 8 5 4 1