Lipanase High Lipase Pancreatic Enzyme Supplement

PRODUCT DATA DOUGLAS LABORATORIES® 04/2012 1

DESCRIPTION Lipanase™, provided by Douglas Laboratories®, is a natural pancreatic enzyme supplement formula providing high strength pancreatin, which is equivalent to 2,400 mg of regular USP pancreatin.

FUNCTIONS The pancreas supplies the major digestive enzymes which catalyze the breakdown of fats, carbohydrates and protein, so that the breakdown products can be absorbed in the upper small intestine. Although fat digestion starts in the mouth with salivary lipase, most fat triglycerides are digested by pancreatic lipase, which is secreted by the exocrine pancreas into the duodenum. Pancreatic lipase separates triglycerides into monoglycerides and free fatty acids, which are efficiently absorbed in the upper small intestine. Some carbohydrate digestion takes place in the mouth by salivary amylase, but pancreatic amylase is the major carbohydrate-digesting enzyme. It breaks down starches into maltose and maltotriose, which are further hydrolyzed into glucose by the disaccharidases of the mucosal cells, and then absorbed. Protein digestion is initiated in the stomach by pepsin and hydrochloric acid, which denature and divide large proteins into smaller polypeptides. The pancreatic proteinases, trypsin and chymotrypsin, break down these polypeptides into free amino acids, and di- or tri-peptides, which are directly absorbed by the intestinal mucosa. Lipanase provides high levels of catalytically active pancreatic enzymes which are specific for fats, carbohydrates and proteins.

INDICATIONS Lipanase tablets may be a useful nutritional adjunct for individuals who wish to supplement their diets with pancreatic lipase, protease and amylase.

FORMULA (#LPN) Each tablet contains: 300 mg 8X Pancreatin. Equivalent to 2,400 mg Pancreatin USP which provides the following minimum enzyme activity: Lipase (fat-specific)...... 12,000 USPUnits Protease (protein-specific) ...... 60,000 USP Units Amylase (starch-specific)...... 60,000 USP Units

SUGGESTED USE One or two tablets with each meal, and with food eaten between meals, not to exceed seven tablets daily, or as directed by a physician.

SIDE EFFECTS No adverse side effects have been reported.

STORAGE Store in a cool, dry place, away from direct light. Keep out of reach of children.

PRODUCT DATA DOUGLAS LABORATORIES® 04/2012 2

Lipanase High Lipase Pancreatic Enzyme Supplement

REFERENCES Gan KH, Heijerman HG, Geus WP, Bakker W, Lamers CB. Comparison of a high lipase pancreatic enzyme extract with a regular pancreatin preparation in adult cystic fibrosis patients. Aliment Pharmacol Ther 1994;8:603-607. Graham DY. Enzyme replacement therapy of exocrine pancreatic insufficiency in man. N Engl J Med 1977;296:1314-1317. Ihse I, Andersson R, Axelson J. Pancreatic pain: is there a medical alternative to surgery? Digestion 1993;54 Suppl 2:30-34. Kraisinger M, Hochhaus G, Stecenko A, Bowser E, Hendeles L. Clinical pharmacology of pancreatic enzymes in patients with cystic fibrosis and in vitro performance of microencapsulated formulations. J Clin Pharmacol 1994;34:158-166. Lankisch PG. Enzyme treatment of exocrine pancreatic insufficiency in chronic pancreatitis. Digestion 1993;54 Suppl 2:21-29. Malesci A, Mariani A, Mezzi G, Bocchia P, Basilico M. New enteric-coated high-lipase pancreatic extract in the treatment of pancreatic steatorrhea. J Clin Gastroenterol 1994;18:32-35. McMahon MJ. Acute pancreatitis: when is enzyme treatment indicated? Digestion 1993;54 Suppl 2:40-42.

For more information on Lipanase visit douglaslabs.com

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Manufactured by Douglas Laboratories 600 Boyce Road Pittsburgh, PA 15205 800-245-4440 You trust Douglas Laboratories. douglaslabs.com Your patients trust you.