The American Society for Mass Spectrometry
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Neighbourhoods in England Rated E for Green Space, Friends of The
Neighbourhoods in England rated E for Green Space, Friends of the Earth, September 2020 Neighbourhood_Name Local_authority Marsh Barn & Widewater Adur Wick & Toddington Arun Littlehampton West and River Arun Bognor Regis Central Arun Kirkby Central Ashfield Washford & Stanhope Ashford Becontree Heath Barking and Dagenham Becontree West Barking and Dagenham Barking Central Barking and Dagenham Goresbrook & Scrattons Farm Barking and Dagenham Creekmouth & Barking Riverside Barking and Dagenham Gascoigne Estate & Roding Riverside Barking and Dagenham Becontree North Barking and Dagenham New Barnet West Barnet Woodside Park Barnet Edgware Central Barnet North Finchley Barnet Colney Hatch Barnet Grahame Park Barnet East Finchley Barnet Colindale Barnet Hendon Central Barnet Golders Green North Barnet Brent Cross & Staples Corner Barnet Cudworth Village Barnsley Abbotsmead & Salthouse Barrow-in-Furness Barrow Central Barrow-in-Furness Basildon Central & Pipps Hill Basildon Laindon Central Basildon Eversley Basildon Barstable Basildon Popley Basingstoke and Deane Winklebury & Rooksdown Basingstoke and Deane Oldfield Park West Bath and North East Somerset Odd Down Bath and North East Somerset Harpur Bedford Castle & Kingsway Bedford Queens Park Bedford Kempston West & South Bedford South Thamesmead Bexley Belvedere & Lessness Heath Bexley Erith East Bexley Lesnes Abbey Bexley Slade Green & Crayford Marshes Bexley Lesney Farm & Colyers East Bexley Old Oscott Birmingham Perry Beeches East Birmingham Castle Vale Birmingham Birchfield East Birmingham -
Module 2.7.1 Summary of Biopharmaceutic Studies and Associated Analytical Methods
CONFIDENTIAL 2.7.1 Summary of Biopharmaceutic Studies and Associated Analytical Methods Module 2.7.1 Summary of Biopharmaceutic Studies and Associated Analytical Methods Copyright 2012 ViiV Healthcare and the GlaxoSmithKline group of companies. All rights reserved. Unauthorized copying or use of this information is prohibited. 1 CONFIDENTIAL 2.7.1 Summary of Biopharmaceutic Studies and Associated Analytical Methods TABLE OF CONTENTS PAGE ABBREVIATIONS ...........................................................................................................3 1. BACKGROUND AND OVERVIEW ...........................................................................4 1.1. Conclusions ..................................................................................................4 1.2. Formulation Development.............................................................................5 1.3. In Vitro Dissolution Data .............................................................................10 1.3.1. Comparative of 2 x 25 mg Clinical Tablets and 1 x 50 mg Clinical Tablets, Phase III Formulation.........................................10 1.3.2. Comparison of Phase III Clinical Image and Commercial Image Tablets..............................................................................13 1.4. Analytical Methods......................................................................................17 1.4.1. Validation.....................................................................................17 1.4.2. Summary of Within Study Quality -
Recent Progress in Laser Analytics
KOLUMNE 417 CHIMIA 44 (1990) Nr.I~ (Ikzem""r) Chimia 44 (/990) 417 424 <&') Schll'ei=. Chemiker- Verhand; ISSN 0009 4293 Recent Progress in Laser Analytics Analytical methods are on their way to mass spectrometry (MS). In 1946, William penetrate the biological sciences. In this E. Stephens (University of Pennsylvania in trend, laser technology plays an important Philadelphia) described a mass spectrome- role, especially in the form of laser-desorp- ter with time dispersion, followed by the tion mass spectrometry (LD-MS). ion velocitron of A.E. Cameron and D.£. The remarkable progress made in this Eggers. These devices represented early field is nicely demonstrated by a statement forms of the time-of-flight mass spectrom- made in 1986 by Frank H. Field, a specialist eter (TOF-MS) first described by the Swiss in the mass spectrometric investigation of R. Keller in 1949. biomolecules and Professor at Rockefeller The first commercially successful TOF- University in New York. Citing Professor MS was introduced by Bendix Corpora- In dieser Kalwnne schreibl Field: 'The mass region of real interest for tion, and it was based on the design re- Prof Dr. H. M. Widmer proteins lies between 40000 and 100000 ported in 1955 by William C. Wile)' and Forse/lUng Analylik Da, and one can only speculate as to l. H. McLaren (Bendix Aviation Corpom- Ciha-Geigy AG. FO 3.2 CH 4{)()2 Basel whether such monster gaseos ions could be tion). In these early days of TOF-MS, the regelmiissig eigene Meinungsarlike/ oder liidl Giiste produced. My personal feeling is that to do ions were generated by electron impact ein. -
From Fragmentation Mechanisms to Sequencing: Tandem Mass Spectrometry Based Peptide and Protein Identification
B American Society for Mass Spectrometry, 2012 J. Am. Soc. Mass Spectrom. (2012) 23:575Y576 DOI: 10.1007/s13361-012-0358-2 FOCUS: MS/MS PEPTIDE IDENTIFICATION: CONFERENCE REVIEW 23rd Sanibel Conference on Mass Spectrometry: From Fragmentation Mechanisms to Sequencing: Tandem Mass Spectrometry Based Peptide and Protein Identification Béla Paizs,1 Matthias Mann2 1German Cancer Research Center, Heidelberg, Germany 2Max-Planck Institute of Biochemistry, Martinsried, Germany he 23rd Sanibel Conference, sponsored by the American sequencing strategy. As a direct result of this parallel and TSociety for Mass Spectrometry, was held January 21– independent development, recent mechanistic insights into 24, 2011, at the TradeWinds Island Grand Hotel, St. Pete peptide fragmentation are seldom incorporated into the most Beach, Florida. The topic of this year was “From popular peptide identification or sequencing algorithms. Fragmentation Mechanisms to Sequencing: Tandem Mass These software packages are mainly based on peptide Spectrometry-Based Peptide and Protein Identification.” fragmentation models developed in the mid 1990s. The conference was co-organized by Béla Paizs, German The purpose of the 23rd Sanibel conference was to Cancer Research Center, Heidelberg, Germany, and bring the peptide fragmentation and bioinformatics Matthias Mann, Max-Planck Institute of Biochemistry, communities closer to each other by offering a forum Martinsried, Germany. to create a common language, exchange ideas, and A key information unit in the use of tandem mass establish joint research projects. This initiative was spectrometry (MS/MS) in proteomics is the product-ion well-appreciated by the community, and the conference spectrum of peptides or intact proteins. Most of the basic attracted a record attendance in the history of Sanibel biological and clinical investigations in proteomics face meetings with 200 participants presenting 27 invited the problem of peptide or protein sequencing by using lectures and submitting 77 poster abstracts. -
20 13 Rep Or T
2013 REPORT More Than 240 Medicines in Development for Leukemia, Lymphoma and Other Blood Cancers Every 4 minutes a person is diagnosed with leukemia, Medicines in Development lymphoma or For Leading Blood Cancers myeloma; Accounting for Application Submitted 9% of all cancers Phase III diagnosed each year Phase II Biopharmaceutical research companies • 15 each for myeloproliferative neo- Phase I are developing 241 medicines for blood plasms, such as myelofibrosis, poly- cancers—leukemia, lymphoma and cythemia vera and essential throm- 97 98 myeloma. This report lists medicines in bocythemia; and for myelodysplastic human clinical trials or under review by syndromes, which are diseases affect- the U.S. Food and Drug Administration ing the blood and bone marrow. (FDA). These medicines in development offer The medicines in development include: hope for greater survival for the thou- sands of Americans who are affected by • 98 for lymphoma, including Hodgkin these cancers of the blood. and non-Hodgkin lymphoma, which 52 affect nearly 80,000 Americans each Definitions for the cancers listed in this year. report and other terms can be found on page 27. Links to sponsor company web • 97 for leukemia, including the four sites provide more information on the major types, which affect nearly potential products. 50,000 people in the United States 24 each year. For information on the value of medi- cines, an in-depth look at current in- • 52 for myeloma, a cancer of the novation and key medical breakthroughs plasma cells, which impacts more benefiting blood cancer patients, please than 22,000 people each year in the see Medicines in Development for Leu- United States. -
(2) Patent Application Publication (10) Pub. No.: US 2009/0226500 A1 Avelar Et Al
US 20090226500A1 (19) United States (2) Patent Application Publication (10) Pub. No.: US 2009/0226500 A1 Avelar et al. (43) Pub. Date: Sep. 10, 2009 (54) SUTURES AND ANTI-SCARRINGAGENTS Related U.S. Application Data (75) Inventors: Rui Avelar, Vancouver (CA); (60) Provisional application No. 60/763,945, filed on Jan. Arpita Maiti, Vancouver (CA); 31, 2006. Philip M. Toleikis, Vancouver (CA); Johanne Diane Cashman, Publication Classification Vancouver (CA); David M. (51) Int. Cl. Gravett, Mountain View, CA (US) A6.1 F 2/04 (2006.01) Correspondence Address: A61 K. 3 1/135 (2006.01) SEED INTELLECTUAL PROPERTY LAW A61R 31/553 (2006.01) GROUP PLLC A61 K 31/496 (2006.01) 701 FIFTHAVENUE, SUITE 5400 A61 K 31/4164 (2006.01) SEATTLE, WA 98104-7092 (US) A61R 31/395 (2006.01) A61 K 37/426 (2006.01) (73) Assignee: Angiotech Pharmaceuticals, Inc, (52) U.S. Cl. .................... 424/423: 514/649; 514/211.08; Vancouver (CA) 514/254.07: 514/399; 514/183; 514/370 (21) Appl. No.: 12/162,572 (57) ABSTRACT (22) PCT Filed: Jan. 31, 2007 Sutures are used in combination with anti-scarring agents to (86) PCT No.: PCT/US07/02714 inhibit fibrosis between the sutures and the host tissues into which the sutures are inserted. Compositions and methods are § 371 (c)(1), described for use in reducing excessive scarring, surgical (2), (4) Date: May 6, 2009 adhesion, and other disorders. Patent Application Publication Sep. 10, 2009 Sheet 1 of 29 US 2009/0226500 A1 Patent Application Publication Sep. 10, 2009 Sheet 2 of 29 US 2009/0226500 A1 ºs||eoL-AHLKquoqonpoudp-JNLWu018=ºolZ802-14Ke8 Patent Application Publication Sep. -
58TH ASMS CONFERENCE on MASS SPECTROMETRY MAY 23 – 27, 2010 Z SHORT COURSES: MAY 22 - 23, 2010 Salt Lake City, Utah
58TH ASMS CONFERENCE ON MASS SPECTROMETRY MAY 23 – 27, 2010 z SHORT COURSES: MAY 22 - 23, 2010 Salt Lake City, Utah LOCATION. The conference and short courses will be held at the Salt Palace Convention Center, 100 South West Temple, Salt Lake City, UT 84101. All oral sessions, poster sessions, exhibit booths and hospitality suites will be located in the convention center. REGISTRATION. On-site conference registration will open 2:00 pm, Saturday, May 22 in the convention center. There is no on-site registration for short courses. For more information: www.asms.org American Society for Mass Spectrometry 2019 Galisteo Street, Building I-1, Santa Fe, NM 87505 Phone: (505) 989-4517 Fax: (505) 989-1073 [email protected] www.asms.org Vice President for Programs: Scott A. McLuckey TABLE OF CONTENTS New This Year ........................................................ S2 ASMS Awards ........................................................ S3 Research Awards .................................................... S4 Program Overview .................................................. S5 Workshops .............................................................. S7 Sunday Program .................................................... S10 Monday Morning Oral Sessions ........................... S10 Monday Afternoon Oral Sessions ......................... S13 Tuesday Morning Oral Sessions ........................... S15 Tuesday Afternoon Oral Sessions ......................... S17 Wednesday Morning Oral Sessions ...................... S20 Wednesday Afternoon -
Novartis Venture Funds
N O V A R T I S VENTURE FUnDS activityreport 2010 2 l activity report 2010 Contents 04 Introduction 06 Investment Philosophy and Focus 08 Highlights 12 Our Funds 16 Geographic Presence 18 Pipelines of Portfolio Companies 22 Medical Device and Diagnostics 24 Private Equity Portfolio 32 Board of Directors 36 Fund Management 38 Contact Information 3 l activity report 2010 mission statement Investing in innovative life science companies for patient benefit creating attractive returns for entrepreneurs and investors 4 l activity report 2010 introduction francis waldvogel Letter from the Chairman of the Medical sciences have indeed never been as cre- Novartis Venture Fund ative, diversified, and dynamic as today, emerging Ranking systems have become fashionable: from from a real melting pot where physics, material sci- air transport to the life style of cities, from health ences, chemistry, biology, genetics, informatics and care systems to universities, we can today estab- robotics converge. Miniaturization and nanoscale lish the list of the best places to be in or the most developments also move into the field. We believe dedicated services to be bestowed with. Corporate therefore that this is a time for great opportuni- Venture Funds are also part of this trend, and to our ties to develop novel diagnostic tools, therapeu- great satisfaction, the Novartis Venture Funds (NVF) tic agents and medical devices for unmet patients’ have been ranked among the top performers in the needs, and that a diversified, multidisciplinary team life science field. is a must to develop these opportunities. Ranking systems, however, have their method- ological limitations and intellectual shortcomings. -
2 FG9A Nationale Patente Brevets Nationaux Brevetti Nazionali
15.4.2003 +pat+ 7 2 FG9A Daniela Montanari K Mehrzweckwerkzeug. Piazza Zanellato, 5 O Ejup Sulejmani Nationale Patente I-35129 Padova (IT) Klybeckstrasse 42 P Rottmann, Zimmermann + 4057 Basel (CH) Brevets nationaux Partner AG N Ejup Sulejmani Glattalstrasse 37 Gundeldingerrain 41 8052 Zürich (CH) 4059 Basel (CH) Brevetti nazionali P I A61N001/05 Abatron-Patentbüro AG A 693 200 Altstetterstrasse 224 B 02509/98 Postfach 2.3 FG3A C 18.12.1998 8048 Zürich (CH) F 10.01.1998 DE 198 00 697.7 I B 23 B 051/08 Z B 23 B 027/16 Ohne Vorprüfung erteilte K Einzel-Elektrodensonde, A 693 203 Patente insbesondere für implantierbare I Z Defibrillatoren. B 24 B 003/48 C 23 F 001/06 A Brevets délivrés sans O Biotronik Mess- und Therapiegeräte 693 210 examen préalable GmbH & Co. Ingenieurbüro Berlin I B 24 B 003/54 Z C 23 F 001/06 Woermannkehre 1 A 693 210 Brevetti rilasciati senza D-12359 Berlin (DE) esame preventivo N Dr. Tran Thong I B 24 B 055/03 Z B 01 D 037/00 12491 NW Woodland Court A 693 201 Portland, Oregon 97229 (US) I B 27 G 013/00 Z B 23 B 027/16 P I A 01 C 003/02 Z B 65 D 090/42 Patentanwälte Schaad, Balass, A 693 203 A 693 207 Menzl & Partner AG Dufourstrasse 101 I B60N002/48 I A47F007/10 8034 Zürich (CH) A 693 204 A 693 197 B 01795/98 I B 01793/98 B01D037/00, B 24 B 055/03 C 02.09.1998 A C 02.09.1998 693 201 F 05.09.1997 DE 297 16 525.9 B K Halter für die Verkaufspräsentation 00941/98 03.11.1997 DE 297 20 023.2 C von textilen Artikeln, insbesondere 24.04.1998 K Kopfstütze und Polster- oder F Strümpfen und Gestell mit solchen 25.04.1997 JP 9-108611 Kissenelement für Kopfstütze. -
Nature Milestones Mass Spectrometry October 2015
October 2015 www.nature.com/milestones/mass-spec MILESTONES Mass Spectrometry Produced with support from: Produced by: Nature Methods, Nature, Nature Biotechnology, Nature Chemical Biology and Nature Protocols MILESTONES Mass Spectrometry MILESTONES COLLECTION 4 Timeline 5 Discovering the power of mass-to-charge (1910 ) NATURE METHODS: COMMENTARY 23 Mass spectrometry in high-throughput 6 Development of ionization methods (1929) proteomics: ready for the big time 7 Isotopes and ancient environments (1939) Tommy Nilsson, Matthias Mann, Ruedi Aebersold, John R Yates III, Amos Bairoch & John J M Bergeron 8 When a velocitron meets a reflectron (1946) 8 Spinning ion trajectories (1949) NATURE: REVIEW Fly out of the traps (1953) 9 28 The biological impact of mass-spectrometry- 10 Breaking down problems (1956) based proteomics 10 Amicable separations (1959) Benjamin F. Cravatt, Gabriel M. Simon & John R. Yates III 11 Solving the primary structure of peptides (1959) 12 A technique to carry a torch for (1961) NATURE: REVIEW 12 The pixelation of mass spectrometry (1962) 38 Metabolic phenotyping in clinical and surgical 13 Conquering carbohydrate complexity (1963) environments Jeremy K. Nicholson, Elaine Holmes, 14 Forming fragments (1966) James M. Kinross, Ara W. Darzi, Zoltan Takats & 14 Seeing the full picture of metabolism (1966) John C. Lindon 15 Electrospray makes molecular elephants fly (1968) 16 Signatures of disease (1975) 16 Reduce complexity by choosing your reactions (1978) 17 Enter the matrix (1985) 18 Dynamic protein structures (1991) 19 Protein discovery goes global (1993) 20 In pursuit of PTMs (1995) 21 Putting the pieces together (1999) CITING THE MILESTONES CONTRIBUTING JOURNALS UK/Europe/ROW (excluding Japan): The Nature Milestones: Mass Spectroscopy supplement has been published as Nature Methods, Nature, Nature Biotechnology, Nature Publishing Group, Subscriptions, a joint project between Nature Methods, Nature, Nature Biotechnology, Nature Chemical Biology and Nature Protocols. -
Alphabetical List)
Information taken from Original Compilation by Jim MacDonald, Guardsman 2623630, 6th Battalion Grenadier Guards, and enhanced. Copyright by written permission only. Grenadier Guards Enlisted Casualties - 2nd World War (Alphabetical List) Name: Initial: Number: Rank: Battalion: Casualty: Place: Fell: Age: At Rest: Remarks: Son of Christopher and Mary Ann Gale, Salerno Lance of Radmanthwaite, Nottinghamshire. Gale C. 2622046 6th D.W Italy 13-Sep-1943 21 War Cemetery, Corporal Buried in Plot II, Row F, Grave 12 Italy Grave Photo shown below. Last Resting Place: Salerno, Italy. Lance Corporal - C. Gale (2622046) 6th Battalion. Manchester (Philips Park) Son of May Gale, of Manchester. Gale G. 2618050 Guardsman 3rd D.A.S England 23-Apr-1941 27 Cemetery, Buried in Section N, Church Grave 1353 Lancashire York Son of Harry and Maud Gamble, Training Gamble H. 2622768 Guardsman D.A.S England 11-Jun-1942 21 Cemetery, of Tang Hall, York. Battalion Yorkshire Buried in Section D, Row 37, Grave 12028 Bone Son of Kensington Gammell, A.R.I.B.A., and of North War Cemetery Doris Gage Gammell, of Bedford. Gammell K.O. 2622616 Guardsman 6th D.W 24-Dec-1943 33 Africa Annaba, B.A. (Cantab.) Gonville and Caius, 1928-1931 Algeria Buried in Plot III, Row C, Grave 18 Massicault Husband of Kathleen Margaret Gardener, North Gardener H.T. 2619728 Guardsman 5th K.A 27-Apr-1943 23 War Cemetery, of Stratford, Essex. Africa Tunisia Buried in Plot V, Row F, Grave 20 Thibar Seminary Son of Albert and Mary Ann Gardner, North Gardner A. 2620496 Guardsman 5th K.A 21-Apr-1943 33 War Cemetery, of Bethnal Green, London. -
Turnham, Margaret H. (2012) Roman Catholic Revivalism
Roman Catholic Revivalism: A study of the area that became the Diocese of Middlesbrough 1779-1992 Margaret H. Turnham, B.Ed., M.Th. Thesis submitted to the University of Nottingham for the degree of Doctor of Philosophy. July 2012 i Abstract This thesis seeks to provide a grassroots study of the diocese of Middlesbrough (1779-1992), in order to contribute to the history of the English Catholic community since it emerged from the Penal Times. Secondly, it is an examination of the manifestation of revivalism and renewal in Catholic devotional practice. The geographical extent of the study covers an area of Yorkshire with a strong recusant history, and that period has been well-served in Catholic historiography. However, writing on the period following the easing of the Penal Laws on Catholics and into the nineteenth and twentieth centuries is remarkable for the paucity of references to the diocese and the area that it covers. Therefore this study sheds light upon a particular Catholic community that has been largely invisible to historians. Although the Catholic community itself might appear to be invisible, the devotional practice within it offers many insights, such as the extent to which the social culture influenced the practice of faith. Therefore it teases out and examines the changing nature of devotional practice, and compares it to aspects of Evangelical revivalism that provided the surrounding religious culture. It also examines the influences that came to bear upon the community itself, assessing their importance in the revival and renewal of faith of the people within it. By examining the history of Catholic devotional practice in this area of Yorkshire, it comes to the conclusion that revivalism and renewal are integral elements in Catholic devotion and as a result Catholics and Evangelicals have more in common with each other than their adherents have been ready to acknowledge.