Bionics Certificate 2

Investment Case

➢ Innovations in the fields of medicine, , and sensors are finally giving a new to medical and are making human enhancement a reality

➢ Bionics, which is taking on human body dysfunctions and disabilities and, more globally, helping improve the wellness and lifespan of the world population, benefits from long-term drivers:

✓ an ageing world population and a shortage of donated organs

✓ major breakthroughs leading to an impressive product pipeline

✓ an improving outlook for the reimbursement of bionic devices by insurers or health agencies

➢ Bionics is not only about next-gen prosthetics, it also covers artificial organs, wearable devices, surgical and medical , synthetic , and artificial intelligence

Bionics Certificate details

✓ Issuing bank: Natixis, Calculation agent: Natixis SA

✓ ISIN: XS1317063912

✓ Currency: USD

✓ Fees: 1.65% management fee + 15% performance fee, high water mark

✓ Bloomberg ticker: NXSRBION Bionics Certificate 3 Bionics Certificate 4

Bionics Is The Merger Between Biology And

Fixing our body dysfunctions Leveraging on Life mechanisms

➢ Replacing limbs and organs ➢ Using them for specific purposes

Seconding humans Improving health

➢ Monitoring metabolism ➢ In particular for surgery Bionics Certificate 5

Elderly Population Increasing Exponentially

➢ According to the UN, the population aged 60 years or over will grow from 962M in 2017 to 2.1Bn in 2050, while the population >80 years old will grow from 137M to 425M

➢ The bulk of the growth comes from Asia: 66% growth of people >60 years old Bionics Certificate 6

We Are Living Longer But Not Necessarily Better

>120k people About 15% of 1.3 billion 466 million in the US are the global people are people have waiting for population visually disabling lifesaving has a disability impaired hearing loss transplants

Source: AtonRa Partners, WHO Bionics Certificate 7

When Moore’s Law Comes To The Labs

➢ Medical technology innovations are made possible thanks to advances in:

Precision Sugery

Artificial Chips intelligence

Genomics Genetic Modification

Virtual Reality

4D Printing Crowdsourcing

➢ Research is performed on extending Moore’s Law by optimizing chip technology

➢ Quantum computing will further extend Moore’s law exponentially Bionics Certificate 8

Health Coverage Of Bionic Devices Has Been An issue…

➢ The price of bionic devices has been unsurprisingly high until now (between $50,000 and $150,000 for an eye or limb device and surgery)

➢ Encouragingly, coverage by Medicare in the US seems to be heading in the right direction

…But Likely To Gradually Expand As Benefits Outweigh Declining Costs

➢ Declining costs and social welfare: a major catalyst for expanded health coverage

✓ some of the technologies used will mature over the years and become less costly

✓ a bionic device can allow people to keep working and return to work more quickly Bionics Certificate 9

Bionics Expected To Grow At A Fast pace

A $113B MARKET BY 2023

CAGR 17-23 Exoskeletons ($2.8B) 45.2%

Synthetic Biology ($37.2B) 27.7%

Medical Robots ($17.6B) 22% AtonRâ Wearable Medical Devices ($14.4B) 18.3% Bionics

Artificial Organs & Bionics ($38.7B) 9%

Healthcare 3D printing ($2.5B) 7.5%

MedTech ($522B) 5.6%

Source: Grand View Research, Marketsandmarkets, Mordor Intelligence, Chief Observer, Infoholic Bionics Certificate 10

The Bionic Man Is Now A Reality

Bionic Limbs

Exoskeletons

Bionic Hearts

Bionic Ears

Bionic Eyes

Bionic Brains Bionics Certificate 11

Synthetic Biology: Making The Impossible Possible

➢ Synthetic biology is the of biology: the synthesis of complex, biologically based systems which display functions that do not exist in

➢ While products that utilize synthetic biology are yet to be commercialized, this market is set to literally explode in the next few years driven by demand for improved drugs and vaccines

➢ Key constraints are mostly ethics and bio-security/safety, as synthetic biology can be misused Bionics Certificate 12

Medical Robots – New Means For Better Medicine

➢ Surgical robots: console, surgical arms, monitoring systems

➢ Telemedicine Robots

➢ Artificial Intelligence applications for diagnosis, monitoring or learning new surgical procedures

➢ Rehabilitation robots, exoskeletons

➢ Robots working in sterile IV (intravenous) preparation rooms. Bionics Certificate 13

Artificial Organs Turning Into Everyday Wearable Devices

➢ The first artificial organ was designed in 1943 to replace a deficient kidney: a dialyzer

BIONIC BODY PARTS

➢ Today, 60-70% of human body functionalities can be artificially performed as demonstrated by Frank, the bionic man Bertolt Meyer designed in 2013 Bionics Certificate 14

Medical Wearable Devices: An Important Link In The Chain

HomeTelehealth Healthcare DiagnosticDiagnostics

Therapeutics

MiniMed 670G: closed loop The Bionic Pancreas: a fully The Zephyr BioPatch: a FDA- system that self-adjusts to autonomous, dual-hormone system cleared small device monitoring maintain the sugar level in range the vital signs Bionics Certificate 15

The Advent Of Brain-Connected Prosthetics

➢ Prosthetics are now on their way to offering real limb replacement…

➢ A cochlear implant does the work of damaged parts of the inner ear…

➢ A bionic eye complements impaired …

➢ Sensors deliver electrical signals to the nervous system, enabling the brain to feel / hear / see Bionics Certificate 16

Benefits vs. Risks

Increased accuracy

Safety checks Disclaimer 17

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