Delft

'Without the NanoLab my research would not be possible.' Nanopore sensors

The NanoLabNL cleanrooms are occupied by businesses, start-up companies and academic users like PhD students and postdocs. Magnus Jonsson is one of those postdocs. He is trying to develop new devices at the Kavli Institute of Nanoscience at Delft University of Technology that combine biology and . 'Without the NanoLab my research would not be possible.'

The research 'My research focuses on the development of novel I like the Netherlands. I'd take water over tools. In particular, we develop biophysical tools mountains any day. And the people are open and based on nanophysical phenomena. It sounds friendly. I appreciate the directness of the Dutch. pretty abstract, so let me explain. For example, we It took me a while to get used to it, but now I are interested in creating devices that tells us how like it. much of a particular protein a drop of blood In the future I hope to continue to develop new contains. This is important for medical diagnostics. sensing concepts and my research will hopefully Other examples include tools for the result in useful applications. For example, in pharmaceutical industry. However, we are also medical diagnostic devices or in better DNA interested in making tools for manipulation and sequencing methods. And me? I want to studies of single biomolecules, which can help to continue in academia the coming years, and gain a better understanding of how life works at perhaps I will get the chance to build my own the nanoscale. research group one day..'

Part of our work is based on nanopores. We make The NanoLab a single, very precise tiny hole in a thin membrane. 'I use a lot of the machines in the Kavli NanoLab - You can then pull biological molecules, such as for electron beam lithography, ion beam milling, protein or DNA, through the tiny hole. With our wet and dry etching as well as for sensing method we can detect molecules going characterisation of my devices. Without the through the tiny hole one by one. This allows us to NanoLab my research would not be possible. The study complex structures, such as protein-DNA lab enables us to use state-of-the-art complexes, at the level of single molecules. nanotechnology techniques to develop new biophysical tools and sensor devices. This is The Dutch. essential for our research. 'I grew up in Sweden where I did my studies . And it's not just the machines. The staff is also After earning my PhD in physics, focusing on great. Technicians help me and I can discuss new Name: Magnus Jonsson (age 31) large-scale biosensing, I wanted more. Or rather processes with them. The NanoLab is a state-of- Occupation: Postdoc at the less. I wanted to explore and develop sensors that the-art facility with an open and flexible Department of can sense single molecules. Cees Dekker's lab at atmosphere. We are able to work creatively and Bionanoscience, Kavli Delft University of Technology is one of the innovatively. What would I like to say to potential Institute of Nanoscience, leading groups in the world of single-molecule users? The staff and the technicians are there to TU Delft sensing. And the addition of the NanoLab provides help you. They can help you with your processes. Work: development of bio-nano an important strong fabrication facility. You are not alone.' devices Nationality: Swedish

DNA translocating through a nanopore. Image courtesy Cees Dekker lab TU Delft / Tremani

Kavli NanoLab Delft

Kavli NanoLab Delft is part of Kavli Institute for Expert technologies Nanoscience at Delft University of Technology. • Particle beam processing Kavli Nanolab Delft enables the fabrication of • Large area e-beam lithography electrical, optical, mechanical or fluidic • Advanced reactive plasma etching nanodevices. • Superconducting film growth This way we support our users to achieve • Bionanoimaging and super resolution techniques excellent scientific results, especially in the following research areas: Contact • Quantum Nanoscience (superconducting Frank Dirne detectors for astronomy, single molecule / Managing Director Kavli Nanolab Delft single photon / single spin detection, Mail: [email protected] quantum computing, nanoresonators) Tel: +31 (0)15 278 2357 • Bio Nanoscience (single /single molecule , nanomedicine / nanopore / nanoprobe devices) • Imaging systems (particle optics, plasmonic structures, photonic crystals)

Apart from a basic infrastructure for micro and nanofabrication we have a set of expert technologies.

Facilities within NanoLabNL Rates All of our equipment can be found in our database (at www.nanolabnl.nl). The database We distinguish two rates related to NanoLabNL facility use: can be searched by location, process and sub-process. If you have any questions about - Public rate: Users from public research communities in the Netherlands, e.g. our facilities, please do not hesitate to contact one of our representatives. FOM, STW, NWO, CW, Universities, Research institutes, etc. You can also discuss your technological issues with our technology specialists. Our - Private rate: Other users, private parties. representatives will be more than happy to assist you. For more information please visit www.nanolabnl.nl 3