2016 RESEARCH ANNUAL REPORT

TABLE OF CONTENTS

SUMMARIES OF 2016 NATIONAL INSTITUTES OF HEALTH AND OTHER FEDERAL GRANTS AWARDED TO HFHS

PART 1 – INTERNAL MEDICINE DEPARTMENT

ALLERGY AND IMMUNOLOGY ...... 1

ENDOCRINOLOGY AND METABOLISM ...... 1

GASTROENTEROLOGY ...... 2

HYPERTENSION AND VASCULAR RESEARCH ...... 2

SLEEP MEDICINE ...... 6

PART II – ALL OTHER CLINICAL DEPARTMENTS

DERMATOLOGY…………………………………………………………………………………8

IMAGING RESEARCH PROGRAM……………………………………………………………...9

NEUROLOGY ...... 10

PATHOLOGY ...... 16

RADIATION ONCOLOGY ...... 17

SURGERY ...... 18

UROLOGY ...... 19

PART III POPULATION SCIENCES

CENTER FOR HEALTH POLICY AND HEALTH SERVICES RESEARCH ...... 20

DEPARTMENT OF PUBLIC HEALTH SCIENCES ...... 22

3/10/2017 PUBLICATIONS

ANESTHESIOLOGY ...... 29

BEHAVIORAL HEALTH SERVICES/PSYCHIATRY...... 30

Neuropsychology……………………………………………………………………………...31

CENTER FOR HEALTH POLICY AND HEALTH SERVICES RESEARCH………………….32

Center for Health Promotion and Disease Prevention ...... 35

DERMATOLOGY ...... 36

DIAGNOSTIC RADIOLOGY……………………………………………………………………41

EMERGENCY MEDICINE ...... 44

FAMILY MEDICINE…………………………………………………………………………….47

GLOBAL HEALTH INITIATIVE ...... 48

GRADUATE MEDICAL EDUCATION………………………………………………………...48

INTERNAL MEDICINE

Allergy and Immunology……………………………………………………………………..49

Cardiology…………………………………………………………………………………….50

Cardiology/Cardiovascular Research…………………………………………………………58

Endocrinology and Metabolism……………………………………………………………….59

Gastroenterology……………………………………………………………………………...60

Hematology-Oncology……………………………………………………………..………....63

Hematology/Oncology/Hemophilia and Thrombosis Treatment Center………………….….65

Hypertension and Vascular Research…………………………………………………………66

Infectious Diseases……………………………………………………………………………68

Nephrology……………………………………………………………………………………71

Pulmonary and Critical Care Medicine ...... 73

3/10/2017 Pulmonary/Sleep Medicine……………………………………………………………………75

Rheumatology…………………………………………………………………………………77

General Internal Medicine/Palliative Medicine/Other………………………………………..78

NEUROLOGY ...... 81

NEUROSURGERY ...... 88

NURSING………………………………………………………………………………………..93

OBSTETRICS, GYNECOLOGY AND WOMEN’S HEALTH SERVICES ...... 94

OPTHALMOLOGY AND EYE CARE SERVICES ...... 97

ORTHOPAEDICS……………………………………………………………………………….98

Physical Therapy……………………………………………………………………………..100

Podiatry ...... 100

OTOLARYNGOLOGY – HEAD AND NECK SURGERY ...... 101

PATHOLOGY ...... 103

PEDIATRICS...... 107

Neonatology………………………………………………………………………………….107

PHARMACY ...... 108

PUBLIC HEALTH SCIENCES ...... 110

RADIATION ONCOLOGY ...... 119

RESEARCH ADMINISTRATION……………………………………………………………..123

Image Analysis Program……………………………………………………………………..123

Genetics Research……………………………………………………………………………124

SURGERY………………………………………………………………………………………125

Plastic Surgery……………………………………………………………………………….130

UROLOGY………………………………………………………………….…………………...131

3/10/2017 ABSTRACTS

ANESTHESIOLOGY ...... 137

BEHAVIORAL HEALTH SERVICES………………………………………………………...138

CENTER FOR HEALTH POLICY AND HEALTH SERVICES RESEARCH ...... 139

DERMATOLOGY……………………………………………………………………………...140

DIAGNOSTIC RADIOLOGY………………………………………………………………….141

EMERGENCY MEDICINE…………………………………………………………………….142

GLOBAL HEALTH INITIATIVE ...... 143

GRADUATE MEDICAL EDUCATION……………………………………………………….143

INTERNAL MEDICINE

Allergy and Immunology…………………………………………………………………….144

Cardiology/Cardiovascular Research………………………………………………………..145

Endocrinology and Metabolism……………………………………………………………...151

Gastroenterology……………………………………………………………………………..152

Hematology-Oncology……………………………………………………………………….156

Hypertension and Vascular Research………………………………………………………..159

Infectious Disease……………………………………………………………………………160

Nephrology…………………………………………………………………………………...161

Pulmonary and Critical Care Medicine………………………………………………………162

Pulmonary/Sleep Medicine…………………………………………………………………..164

General Internal Medicine/Palliative/Other………………………………………………….166

NEUROLOGY ...... 170

NEUROSURGERY ...... 173

OBSTETRICS, GYNECOLOGY AND WOMEN’S HEALTH SERVICES ...... 175

OPHTHALMOLOGY AND EYE CARE SERVICES ...... 178 3/10/2017 ORTHOPAEDICS AND ATHLETIC MEDICINE ...... 178

OTOLARYNGOLOGY – HEAD AND NECK SURGERY ...... 179

PATHOLOGY ...... 180

PHARMACY ...... 183

PUBLIC HEALTH SCIENCES ...... 184

RADIATION ONCOLOGY ...... 189

RESEARCH ADMINISTRATION

Cytogenetics ...... 193

Image Analysis Program…………………………………………………………………….193

SURGERY ...... 194

UROLOGY ...... 197

3/10/2017 Summaries of 2016 National Institutes of Health and other Federal Grants Awarded to HFHS

Part I –Department of Internal Medicine

• Allergy and Immunology • Endocrinology and Metabolism • Gastroenterology • Hypertension and Vascular Research • Sleep Medicine

Allergy and Immunology

Principal Investigator: Edward Zoratti, M.D. Pets and the Infant Microbiome: Effect on Immune Maturation & Atopic Asthma– Project 2 (NIH P01A1089473)

The Program Project Grant (PPG) application seeks an increased understanding of the relationships between dog or cat exposure during infancy and a lower risk of allergic asthma. We believe that this protective association is related to different patterns of microbial stimulation during immune development. Four synergistic Projects will examine our hypothesis that the presence of pets in a home results in a more diverse bacterial community composition (BCC) of the dust in the home which in turn influences the development of the gut BCC of a newborn infant living in the home. A more diverse gut BCC shifts the maturation of the infant's immune system such that later immune responses are less likely to produce IgE antibody responses and allergic asthma. Project 2 will recruit a new birth cohort of children either living with or without a dog, measure infant stool BCC, and follow the cohort with detailed studies of immune function until 18 months of age to determine the impact of dog exposure on immune maturation. The Projects are supported by five Cores which each provide essential services to all four Projects.

Endocrinology and Metabolism

Principal Investigator: D. Sudhaker Rao, M.D. Pathogenesis of Atypical Femaur Fractures on Long Term Bisphosphonate Therapy (NIH 1R01AR062103)

Bisphosphonates (BP) have been used successfully for over a decade to prevent and treat osteoporosis and reduce osteoporotic fractures. However, since 2005 there have been many reports of atypical femoral fractures (AFF) in patients on prolonged BP therapy. Recently, it has been found that a prodromal bone deterioration (PBD) usually appears before the development to AFF. However, many PBDs may be asymptomatic, not necessarily progress to AFF, and heal spontaneously after discontinuation of BP therapy. Therefore, the prevalence of PBD may be much higher than AFF. To date, there is no evidence to support this hypothesis. It has been reported that many patients with PBD and AFF have severely suppressed bone turnover (SSBT). However, since not all patients with PBD/AFF also have SSBT, factors other than SSBT might contribute to the development of PBD/AFF. Our preliminary study suggests that PBD/AFF may be associated with osteocyte death, bone hypermineralization, and microdamage accumulation which compromise bone mechanical properties. These facts collectively led us to formulate the hypothesis that BP treated patients who develop SSBT and consequent increase in bone age, in conjunction with previous osteocyte deficiency, are predisposed to micropetrosis, accumulation of fatigue microdamage, PBD, and eventually to stress fracture manifested as AFF. To pursue this hypothesis we propose the following specific aims: Aim 1 is to determine the prevalence of PBD and AFF in 1,000 patients with postmenopausal osteoporosis, either treated with BP for more than 2 years (500 subjects), or never BP treated (500 subjects). X-rays of the femurs will be performed to systematically screen the patients for PBD/AFF. PBD can be defined

1 as an X- ray finding of focal cortical thickening associated with a fracture line at the lateral femoral cortex.

Suspected PBD patients, whose x-ray does not show clear fracture line at focally thickened cortex, will be evaluated further using x-ray tomosynthesis, isotope bone scan or MRI. Aim 2 will determine the contribution of osteocyte deficit to PBD/AFF and SSBT in iliac bone biopsies obtained from long term BP treated patients. Degree of bone mineralization and bone nano-mechanical properties will also be assessed on these biopsies.

Gastroenterology

Principal Investigator: Stuart Gordon, M.D. Chronic Hepatitis Cohort Study II (CHeCS-II) (U18PS005154)

Hepatitis B (HBV) affects over 1.25 million Americans, and hepatitis C (HCV) over 3.2 million Americans. In the decades to come, more than 150,000 Americans are expected to die from these conditions unless steps are taken to increase awareness, diagnosis, and access to necessary care and treatment. Emerging interferon-free, direct-acting all-oral antiviral (DAA) treatments have changed the landscape of HCV treatment and care. These treatments appear to be safer than interferon-based treatments and provide exceptionally high rates of sustained virological response (SVR). Both HBV and HCV treatment guidelines have been updated to reflect evidence regarding initiation of new therapies; however, the evidence for those recommendations is largely based on clinical trials conducted under highly controlled conditions in restricted patient populations with limited data collection. Significant health disparities—across race, sex, age, and co-infection (with HIV or dual hepatitis)—may limit the generalizability of these populations.Data from longitudinal cohorts of “real world” hepatitis patients are needed to assess the population impact of rapidly evolving antiviral therapies, to understand the spectrum of disease and its natural history, and to evaluate the public health impact of chronic viral hepatitis.

The Chronic Hepatitis Cohort Study (CHeCS) is the first comprehensive longitudinal cohort study of chronic viral hepatitis in the US, and has served as a model platform for observational data collection in this population. Since 2010, CHeCS has reported valuable information and expanded knowledge on many facets of hepatitis disease and policy. We propose to build upon CHeCS to develop “CHeCS-II,” in order to achieve the long-term goal of applying this rich data and infrastructure resource to inform public health planning, policy decisions, and clinical management of HBV and HCV. To achieve this, we will leverage the established CHeCS infrastructure, which has: (1) a diverse, real-world, non-veteran- based US cohort of >3,000 HBV, >11000 HCV, and >500 HIV co-infected patients receiving care through four U.S. health systems; (2) an experienced multidisciplinary team; (3) an efficient system for patient identification and data collection.

We will provide scientific leadership to identify research findings and priorities by: (1) Offering seamless collaboration across study sites and with the Centers for Disease Control (Aim 1); (2) Expanding our HCV cohort to over 14,000 patients with >2 years’ follow-up; (3) Increasing follow-up of HBV patients to >5 years; (4) Collecting additional data regarding social determinants of health, including access to and uptake of care (Aim 2); (5) Applying rigorous analytical approaches to develop an in-depth understanding of health disparities and comorbidities, as well as investigating how these differences impact access to and uptake of antiviral therapy; (6) Advancing translation of this research to inform hepatitis-related policy and practice (Aim 3).

Hypertension and Vascular Research

Principal Investigator: Oscar A. Carretero, M.D. Project 1 and Project 3 Principal Investigator: Pamela Harding, Ph.D. Project 2 Autocoids in Hypertension: Pathogenesis and End Organ Damage (NIH 2P01HL028982-3)

This PPG was started in September, 1982. The central theme is "the study of the role of vasoactive systems (autocrine, juxtacrine, paracrine and endocrine) in the regulation of renal

2 function and blood pressure (BP) and mediation of end organ damage (EOD)". The general hypothesis to be tested is that there is a balance between systems that promote water and sodium retention, hypertension and EOD, including Angiotensin II (Ang II), prostanoids, reactive oxygen species and inflammation, and systems that antagonize these effects like Ac-SDKP, activation of the Ang II type 2 receptor (AT2), kinins, NO, PGE2/EP4, and the newly discovered cross-talk between the connecting tubule and the afferent arteriole (CTGF) which may participate in both natriuresis and renal damage. Alterations of this balance in favor of the former are responsible for retention of water and sodium and development of hypertension and EOD, while alterations of this balance in favor of the latter have therapeutic effects. We will use molecular, physiological, and pharmacological approaches' to study vasoactive systems at the subcellular, cellular, and isolated organ levels in hypertension in rats and various transgenic and gene knockout mice. We will mainly use Dahl salt-sensitive rats (Dahl SS) and Ang ll-induced hypertensive rats as models. In Project I, using Dahl SS rats, we will study whether N-acetyl-seryl-aspartyl-lysyl-proline protects against EOD by decreasing adaptive immunity. In Project II we will study whether expression of cyclooxygenase-2 and generation of PGE2 via the EP4 receptor protects against EOD in Ang ll- induced hypertension. In Project III, using Dahl SS rats, we will study whether CTGF causes glomerular damage via afferent arterole dilatation and increases in capillary glomerular pressure. In Project IV, using Dahl SS rats, we will study whether a decrease in the renal thick ascending limb AT2-signaling participates in the pathogenesis of hypertension. The Four Cores - Administrative (A), Analytical and Morphological (B), Mutant Mouse (C), and Biostatistics (D) - will support the scientific efforts of the investigators. This PPG provides integration of our efforts, collaboration, sharing of ideas and expertise, thus accelerating acquisition of knowledge on the causes of hypertension and EOD. Project 4, which is subcontracted to Case Western Reserve University in Cleveland, and the 4 Cores are not described in the abstracts below.

Principal Investigator: Oscar A. Carretero, M.D. Project 1:

In hypertension, end organ damage (EOD) is due in part to the mechanical forces exerted by high blood pressure (BP); however, other mechanisms such as inflammation, oxidative stress, the RAS, and genetic predisposition, all play key roles in its pathogenesis. In hypertension, Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP), a naturally occurring peptide hydrolyzed mainly by ACE, reduces cardiovascular and renal inflammation and fibrosis without lowering BP. We have evidence that Ac-SDKP mediates some of the anti-fibrotic and anti- inflammatory effects of ACE inh and also prevents experimental autoimmune myocarditis in rats. Thus we propose to test the general hypothesis that in hypertension Ac-SDKP shifts the balance between pro- inflammatory/pro-oxidative andanti-inflammatory/anti-oxidative systems in favor of the latter by decreasing innate and adaptive immunity and thus slowing the developmentof EOD. Furthermore, the effects of Ac-SDKP on BP and EOD are related to the degree of participation of innate and adaptive immunity in the pathogenesis of hypertension and EOD. This hypothesis will be studied in 3 aims. Aim I: In hypertensive Dahl salt- sensitive rats (Dahl SS) and in mice with systemic lupus erythematosus and hypertension, a model of autoimmune disease, Ac-SDKP acts as an immune modulator, reducing innate and adaptive immunity and thus EOD. Some of the effects of Ac-SDKP depend on the degree of participation of innate and adaptive immunity in the pathogenesis of hypertension and EOD. Aim II: The effects of ACE inh on the pro-inflammatory transcription factor NF- KB, TH cells and Treg cells are mediated by an increase in Ac- SDKP. Aim III: The effects of Ac-SDKP are multiphasic; central to these effects are decreases in: 1) the pro-inflammatory transcription factor NF-KB, 2) differentiation and maturation of dendritic cells (DCs), 3) DC transformation of T cells in effector T cells, and 4) TH cell proliferation, activation, migration, and differentiation into pro- inflammatory phenotypes. The effects of Ac-SDKP on TH are partly due to an increase in Treg cells.Project I is related to III and IV which also study Dahl SS; 2) II and III, which also study the pathogenesis of EOD; and 3) II and IV which also study Ang II. Project 1 will use all 4 Cores.

Project 3:

In hypertension, high glomerular capillary pressure (PGC) leads to glomerulosclerosis. In African- Americans with salt-sensitive (SS) hypertension, high salt intake causes an increase in estimated PGC, which could explain their high rate of hypertensive renal disease. Dahl SS rats on high salt intake have hypertension, high PGC and significant glomerular injury compared to SHR with similar blood pressure.

3 Connecting tubule glomerular feedback (CTGF) is a cross- talk that dilates the afferent arteriole (Af-Art) when Na is increased in the connecting tubule (CNT). General hypothesis: In SS hypertension, during high salt intake there is an imbalance between factors that cause Af- Art constriction (myogenic response and TGF) versus dilatation (CTGF) in favor of the latter, leading to an increase in PGC and glomerular damage. Aim I, Hypothesis, In normotensive animals, chronic high salt intake causes TGF resetting due to heightened CTGF via increased release of EETs and PGE2 by the CNT. Mice with a gain-of-function mutation of ENaC have increased CTGF and reduced TGF, while mice with deletion of ENaC in the CNT have decreased or no CTGF and enhanced TGF. Aim II, hypothesis: In hypertensive Dahl SS rats CTGF is increased, causing TGF resetting leading to increases in PGC and glomerular damage. Conversely, in SHR CTGF is decreased, causing an enhancement of myogenic response and TGF which in turn decreases PGC and protects the glomerulus from damage. In SHR, high salt will increase CTGF, causing attenuation of the myogenic response, TGF resetting, increased PGC, and glomerular damage. In Ang II-induced hypertension in mice with increased ENaC activity, glomerular damage will be greater due to an increase in CTGF, while in mice with selectively decreased ENaC in the CNT glomerular damage will be lower, due to a decrease in CTGF. Aim III, hypothesis: In hypertensive Dahl SS rats, CTGF is augmented due to increases in ENaC, COX-2 and PGE2. In contrast, in SHR CTGF is attenuated due to increased soluble epoxide hydrolase and decreased EET release. Project III is closely related to 1): I and IV which also study Dahl SS; I and II which also study the pathogenesis of EOD; and II which also studies arachidonic acid metabolites. Project III will use all 4 Cores.

Principal Investigator: Pamela Harding, Ph.D. Project 2:

Uncontrolled hypertension (HTN) is a major cause of end organ damage (EOD) and a risk factor for cardiovascular morbidity and mortality. Although prostaglandin E2 (PGE2) was historically thought to be a mediator of inflammation, more recent evidence suggests that it may be pro or anti-inflammatory, depending on the involvement of specific PGE2 EP receptor sub-types that signal through divergent signaling pathways. We previously reported that aged male mice lacking the EP4 receptor on cardiomyocytes develop heart failure characterized by reduced ejection fraction, left ventricle dilation and fibrosis, coupled with elevated expression of chemokines (fractalkine and MCP-5) in the left ventricle. This proposal examines whether the protective and anti-inflammatory effects of PGE2 via EP4 are mediated by reduced fractalkine and MCP-5. It tests the general hypothesis that EP4, activated by PGE2, reduces the EOD that occurs in Angiotensin II (Ang II)-dependent hypertension and myocardial infarction (MI) by inhibiting the production and/or release of the inflammatory chemokines fractalkine and MCP-5. AimI will study whether PGE2 via its EP4 receptor reduces production and /or secretion of fractalkine and MCP-5 via its EP4 receptor and cAMP in cardiac myocytes and fibroblasts and opposes the deleterious effects of Ang II. AIM II will study whether EP4- dependent reductions in fractalkine and/or MCP-5 improve cardiac function both in vivo and in vitro. Aim III will study whether PGE2 via its EP4 receptor and inhibition of fractalkine and/or MCP-5 synthesis and/or release prevents EOD by reducing infiltration of inflammatory cells into the myocardium in models of Ang II- dependent HTN and myocardial infarction (MI). The proposal will utilize a novel mouse model coupled with state-of-the art molecular techniques to address these aims. These studies are of utmost importance in determining the role of PGE2 and EP4 in cardiac hypertrophy and EOD. Project II is closely related to: 1) Projects I and III which also study the pathogenesis of EOD; 2) Project IV which also studies AT1 receptors and superoxide; and 3) Project III which also studies arachidonic acid metabolites. Project II will use all 4 Cores.

Principal Investigator: Mariela Mendez, Ph.D. Hydrogen Peroxide Stimulates Renin Release: Role in Hypertension and Diabetes (NIH R03DK105300)

Hypertension and diabetes are the principal cause for chronic kidney disease (CKD). In both diseases, a high percentage of patients show activation of the renin angiotensin system (RAS). Renin is the rate-limiting enzyme in the activation of the RAS. Thus, understanding the mechanism and proteins involved in the release of renin may offer alternative targets for hypertension and CKD. Renin is stored in dense-core granules in juxtaglomerular (JG) cells, located at the pole of the renal afferent arteriole, in the kidney cortex. In hypertension and diabetes, reactive oxygen

4 species, including hydrogen peroxide (H2O2), are enhanced in the kidney cortex. We found that hydrogen peroxide stimulate renin release from JG cells. However, the enzymes responsible for production of hydrogen peroxide in JG cells have not been identified. Hydrogen peroxide is mainly a product of superoxide dismutation or enzymatic formation by NADPH oxidases (NOX1-5). The NOX4 isoform preferentially produces hydrogen peroxide and its expression in the renal cortex is enhanced in diabetes and hypertension. Our preliminary data shows that NOX4 is expressed in renin granules in JG cells, suggestive of intragranular production of H2O2. However it is not known whether NOX4 produces the pool of hydrogen peroxide that stimulates renin release from JG cells; and whether NOX4/H2O2-induced renin release contributes to increase blood pressure and kidney damage in diabetic nephropathy. In addition the mechanism by which H2O2 stimulate renin release is unknown. In other cells H2O2 induces signaling by oxidation of protein thiols. In this proposal we will test the hypothesis that the NADPH oxidase isoform NOX4 produces hydrogen peroxide in juxtaglomerular cells and stimulate renin release, thereby increasing blood pressure and contributing to glomerular damage. We will also explore the protein targets by which H2O2 stimulates renin release. In Aim 1 we will use primary cultures of juxtaglomerular cells, isolated afferent arterioles and Akita mice to test the role of NOX4-derived hydrogen peroxide in renin release in vitro and in vivo. In Aim 2 we will use a proteomics approach and subcellular fractionation of renin granules, to identify proteins that are oxidized by hydrogen peroxide in juxtaglomerular cells. This approach will allow us to collect critical preliminary data for an RO1 submission and focus on new protein targets of hydrogen peroxide that mediate renin release.

Principal Investigator: Pablo Ortiz, M.D., Ph.D. Fructose Induced Salt-Sensitive Hypertension: Role of Thick Ascending Limb Transport (R01DK107263)

A high-fructose diet is linked to the epidemic of hypertension, diabetes, and obesity. Up to 25 million Americans consume up to 20% of their calories from added fructose1,2. We found that feeding rats a fructose-enriched diet (20%) for 4 weeks did not increase blood pressure.However, a fructose-enriched diet combined with high salt (4% Na) caused salt-sensitive hypertension within 1 week (Figures 1,11); prior to the development of metabolic abnormalities. The initial phase of salt-sensitive hypertension is in part mediated by a renal defect that prevents NaCl excretion during high salt intake. The thick ascending limb (TAL) reabsorbs 25% of filtered NaCl. Enhanced TAL NaCl absorption is related to salt-sensitive hypertension in humans and rodents3-5. However, the mechanism by which a fructose-enriched diet rapidly (1 week) causes salt-sensitive hypertension is not clear and the role of TAL NaCl absorption in this process is completely unknown.

NaCl reabsorption by the TAL depends on the apical Na/K/2Cl cotransporter NKCC2, the target of loop diuretics. Our preliminary data show that a fructose-enriched diet enhanced NKCC2 phosphorylation at Threonine (Thr)96,101. NKCC2 phosphorylation at Thr96,101 activates NKCC26,7. Our data show that NKCC2-mediated NaCl transport is abnormally elevated in rats fed fructose plus a high salt diet. However, the effects of fructose and the signaling induced in the TAL and the distal nephron have not been studied. Our data show that plasma and urine fructose increase rapidly after fructose intake. Thus, fructose reaching the nephron may be transported in by a fructose channel, activating protein kinase signaling. The only kinases known to phosphorylate Thr96,101 of NKCC2 are SPAK (STE20/SPS1- related proline-alanine-rich kinase) and OSR1 (Oxidative Stress Responsive 1) kinases. In the TAL, these kinases specifically phosphorylate NKCC2. In the distal convoluted tubule (DCT), these kinases specifically phosphorylate the thiazide-sensitive NaCl transporter NCC. We found that a 20% fructose diet increases SPAK/OSR1 phosphorylation in TALs. In addition, stimulation of β-adrenergic receptors (β-AR) in the TAL activates NKCC213. A fructose-enriched diet may increase sympathetic activity by 2 weeks12, or enhance the sensitivity or signaling of β-AR. Our preliminary data show that β- AR stimulation increases SPAK/OSR1 phosphorylation in TALs. In the Dahl salt sensitive (SS) rat, NKCC2 and SPAK/OSR1 phosphorylation are abnormally enhanced in a normal salt diet. It is not known whether this increases the effect of fructose on blood pressure and NaCl absorption. We hypothesize that a fructose-enriched diet enhances thick ascending limb (TAL) and distal tubule (DCT) NaCl absorption by inducing NKCC2 and NCC phosphorylation via SPAK/OSR1 kinases and enhanced β-AR signaling. These effects occur within 1 week, prior to metabolic alterations, and are maintained chronically (16 weeks), promoting salt- sensitive hypertension in normal rats. In Dahl SS rats, abnormally elevated SPAK/OSR1 in the TAL, enhances the effect of fructose on

5 blood pressure in normal- or high-salt diets.

Principal Investigator: Tengis Pavlov, Ph.D. Regulation of ENaC in Salt-Sensitive Hypertension via Inflammation-Induced ROS Production (R00HL116603)

Reduced ability to maintain sodium homeostasis and normal levels of arterial pressure is the hallmark of saltsensitive hypertension (SSH). In the kidney, discretionary Na+ reabsorption mediated by epithelium sodium channel (ENaC) is a determinant of the pressure-natriuresis relationship which is of fundamental importance in the long-term control of arterial pressure. According to the initial proposal we continue developing specific aims focused on regulation of ENaC by reactive oxygen species (ROS) in this pathological condition. Our data indicate that ENaC-mediated Na+ reabsorption in the distal nephron contributes to salt-sensitive hypertension in and I hypothesize here that excessive H2O2 production mediates this effect. Using genetically modified strains derived from Dahl Salt-Sensitive rats, we found that ROS production by renal tissue NADPH oxidase significantly contributes to upregulation of ENaC activity associated with high salt consumption. As planned initially, the current proposal is focused on Aim 2 studying cellular and molecular mechanisms by which ROS modulate ENaC activity and complete Aim 1. We hypothesize here that H2O2 production increased in response to high salt diet results in destroying of the actin cytoskeleton and activation of ENaC activity. Moreover, we propose that cortactin and MIM proteins are required for proper regulation of the channel by the actin cytoskeleton. Also, we shall continue studies on the role of different NADPH oxidase subunits and T-cell infiltration in the development of hypertension in Dahl SS rats. This work provides mechanistic insight on the relationships between high salt consumption, development of high blood pressure, inflammation and kidney damage and the role of sodium reabsorption. Such approach allows generating clinically relevant data interesting for broad scientific community.

Sleep Medicine

Principal Investigator: Drake, Christopher, Ph.D. Behavioral Treatment of Menopausal Insomnia; Sleep, Depression, Daytime Outcomes (NIH R01NR013959)

Insomnia is recognized as one of the most prevalent and costly sleep disorders and is associated with considerable morbidity including significantly reduced quality of life, impaired work performance, and increased risk for major depressive disorder. Insomnia is a key symptom of the menopausal transition with 40-50% of postmenopausal women (> 17 million) having insomnia. Insomnia associated with menopause has a pattern of sleep disturbance predominantly characterized by sleep maintenance difficulties including frequent awakenings and arousals, reduced sleep efficiency, and overall fragmented sleep. It has recently been demonstrated that this pattern of sleep disturbance, difficulty maintaining sleep, increases throughout the progression of menopause. We have recently found sleep maintenance problems in menopause are associated with reduced work performance, increased healthcare utilization, and impaired quality of life. Historically, menopausal symptoms including sleep disturbance, were treated using hormone replacement therapy (HRT). However, evidence linking HRT to increased risks of heart disease and cancer have led to a 40% reduction in the use of sex steroid hormones by postmenopausal women and highlight the need for alternative approaches to treatment. Importantly, the American Association of Clinical Endocrinologists guidelines for management of menopause do not address treatment of menopausal-related insomnia due to the absence of research findings in this area. Cognitive-behavioral therapy for insomnia (CBT-I) yields equivalent short-term efficacy and superior long-term durability to pharmacological treatment of insomnia.However, the efficacy of cognitive behavioral therapy for insomnia comorbid with menopause, one of the primary focuses of the present proposal, has not been tested. Traditional CBT-I has disadvantages however, including the need for a trained therapist and significant time commitment on the part of the patient. Therefore, widespread availability of multicomponent CBT-I is limited by the relatively low number of CBT sleep specialists, complexity of therapy, and patient burden. Thus, another aim of this project is to test the acute and long-term efficacy of a single component behavioral therapy for menopausal- related insomnia. Given the significant daytime impairment present in insomnia comorbid with menopause including depression, quality of life, and fatigue, a final aim of this proposal is to determine the efficacy of CBT-I on these measures in women with menopausal-related insomnia. 6

The project will test the efficacy of cognitive-behavioral therapy for insomnia (CBT-I), as a safe and effective evidence-based alternative to medication for sleep disturbance associated with menopause. Because CBT-I is costly and time intensive, we will also test the efficacy of abbreviated single component sleep restriction therapy (SRT) in the treatment of menopausal- insomnia. Importantly, we will also test the efficacy of each of these treatments on improvements in depression, fatigue, and quality of life.

Principal Investigator: Timothy Roehrs, Ph.D. Risks for Transition from Therapeutic Hypnotic Use to Abuse (NIH R01DA038177)

The acknowledged drugs of choice for the pharmacological treatment of insomnia are the benzodiazepine receptor ligand hypnotics (BzRL). Our nighttime studies show that with therapeutic doses used either short-term or chronically, the abuse liability of BzRLs in insomnia is not seen universally and is relatively low. The data from our last grant, a first-ever study, showed the abuse liability of chronic zolpidem use in insomniacs was low. Yet case reports and retrospective studies continue to report BzRL dependence and for the majority of these cases the abuse developed through initial therapeutic use. In our study some subjects showed an increase in dose across time. Understanding the transition from therapeutic use to abuse and identifying risk factors, such as specific patient and drug characteristics, is both mechanistically and clinically important. Our preliminary data have shown that a subset of insomniacs, those insomniacs that have signs of hyperarousal as reflected by elevated Multiple Sleep Latency Test (MSLT) scores, increased their nightly zolpidem dose across time. BzRLs have differential receptor binding affinities and associated anxiolytic or antidepressant properties. Zolpidem has selective alpha 1 BzRL affinity and little mood activity and thus may show less risk for transition from therapeutic use to abuse than another currently frequently prescribed BzRL with less alpha subtype selectivity such as eszopiclone. We propose to study the abuse liability of a selective (zolpidem) vs nonselective (eszopiclone) hypnotic during chronic use (six months) in an at-risk sub- population (insomniacs with hyperarousal shown by elevated MSLTs). The proposal is highly innovative as it reflects a paradigm shift in understanding the abuse liability of hypnotics. In the end, this proposal will generate a unique set of data addressing a number of previously clinically important unanswered questions regarding hypnotic abuse by insomniacs (i.e., its likelihood as a function of arousal state and specific hypnotic pharmacology, of dose escalation over time and change in mood/drug effect ratings over time). It will provide clinicians with behavioral indicators of abuse risk.

7 Part II – All Other Clinical Departments

• Dermatology • Imaging Research Program • Neurology • Pathology • Radiation Oncology • Surgery • Urology

Dermatology

Principal Investigator: Qing-Sheng Mi, M.D., Ph.D. microRNAs and NKT Cell Development and Function (NIH R01AI119041)

Natural killer T (NKT) cells are an evolutionarily conserved subset of T cells that are developmentally and functionally distinct from conventional T cells. The ability to quickly secrete large quantities of a variety of cytokines upon activation enables NKT cells to be potent regulators of diverse immune responses. The deficiencies in NKT cell number and function have been linked to the development of many diseases. However, a significant gap remains in our understanding of how the development and function of NKT cells are precisely regulated. MicroRNAs (miRNAs), a recently discovered class of evolutionarily conserved small non- coding RNAs, negatively regulate the expression of protein-coding genes and thereby control essential biological functions and contribute to the development of many diseases. We were the first to report that the deletion of Dicer (a key enzyme for miRNA biogenesis) during hematopoiesis results in a significantly reduced NKT cell number and impaired NKT cell maturation and function, without alternating conventional T cell development in the thymus, suggesting that miRNAs are required for NKT cells. Our long-term goal is to understand how miRNAs regulate NKT cell development and function. While more than 1000 experimentally reported miRNAs, very few specific miRNAs are linked to NKT cells so far. Our objective here is to define specific miRNAs and their targets that regulate NKT cell development and function. Using miRNA arrays, we recently identified dynamic expression of miRNAs, including miR- 155, and miR-17-92 cluster, during NKT cell development and activation. These findings plus our recent other report lead to our central hypothesis that these dynamically expressed miRNAs serve as critical regulators controlling NKT cell development and function through fine-tuning of specific target genes. Here we will further test this hypothesis. We will investigate how dynamic and miR-155 and miR-17-92 expression regulates NKT cell development and function using specific miRNA mutant mice with the gain or loss of miRNA gene. The results from proposed studies may not only illuminate the new immunological and molecular mechanisms underlying NKT cell development, but may also facilitate the development of new and more efficient intervention strategies for autoimmune diseases, infection, and cancer based on the NKT cell therapy.

Principal Investigator: Qing-Sheng Mi, M.D., Ph.D. Roles of HDAC3 in Epidermal Langerhans Cell Ontogeny and Function (NIHR01AR069681)

Langerhans cells (LCs), the skin residing dendritic cells (DCs), form a contiguous immune network in skin and are involved in allergy, infection, cancer, and autoimmune disease development. However, the regulatory mechanisms involved in the development and functions of LCs have not been completely elucidated. Histone deacetylases (HDACs) are enzymes that regulate gene expression by modifying chromatin structure through removal of acetyl groups from target histones or directly deacetylating nonhistone proteins, and represent a key epigenetic regulatory mechanism. HDAC inhibitors (HDI) are shown to have anti-tumor and anti- inflammatory effects in a variety of diseases, in which LCs play an important role. However, the mechanisms underlying the clinical effectiveness of HDI remain largely unknown. We recently reported that the inhibition of Class I/II HDACs by Trichostatin A (TSA) regulates the homeostasis and function of LCs in vitro and in vivo and modulates the non-coding miRNA expressions in LCs, while miRNAs also control LC development and function. Our preliminary data indicate that LCs express all Class I/II HDACs. To evaluate the role of individual HDACs in LC

8 development and function, we generated knockout (KO) mice with selective deletion of HDAC3 (Class I) or HDAC4 (Class II) in epidermal LCs. Interestingly, LC number was significantly reduced in LC- HDAC3KO mice, but unaffected in LC-HDAC4KO mice. Furthermore, LC maturation and function were altered in LC-HDAC3KO mice. Thus, we hypothesize that HDAC3 is a key epigenetic component that controls LC development and function. In Aim 1, we will investigate the roles of HDAC3 in LC development and homeostasis, using LC-HDAC3KO mice for homeostasis after birth and using constitutive Csf1r-specific HDAC3-deletion mice (Csf1r-HDAC3) and inducible Csf1rspecific HDAC3- deletion (Csfr1.Mer-HDAC3) mice for early embryonic LC development; Aim 2, we will investigate the roles of HDAC3 in LC function, using inducible LCER. HDAC3KO mice. In Aim 3, we will elucidate the molecular mechanisms and signaling pathways by which HDAC3 regulates LC development and function, by combining cDNA array, miRNA array and ChiP-Seq techniques. The proposed studies will uncover the epigenetic regulatory mechanisms of HDAC3 in LC development and function, and may also elucidate new mechanisms for HDI therapy.

Principal Investigator: Qing-Sheng Mi, M.D., Ph.D. Serum MicroRNA Biomarkers of Islet Autoimmunity (NIH R01AI123258)

Under Dr. Mi’s leadership, the team at Henry Ford Health System will perform miRseq profiles and quantitative miRNA analysis on serum samples using the Exiqon RT�PCR platform. Based on preliminary data, a custom panel of 188 microRNAs will be used. This strategy will allow greatly reducing the cost of measuring microRNAs by almost 50% and yet allow to study serum microRNA extensively; making it possible to measure a larger number of samples for increased statistical power. Over the course of the four year program, we anticipate measuring microRNA levels in 600 serum samples from the DPT�1 cohort, as described in the experimental plan. In addition to this, the team at Henry Ford Health System will perform miRseq to define potential candidates that may be missed by the Exiqon platform.

Imaging Research Program

Principal Investigator: Soltanian-Zadeh, Hamid, Ph.D. Decision Support System for Temporal Lobe Epilepsy (NIH R01EB013227)

With the ever-increasing role of medical images in diagnosis, treatment planning, and evaluation of treatment effects, extraction of quantitative information from these images and efficient use of the results have become a necessity. In recent years, we have developed novel three-dimensional (3D) knowledge-based methods to segment brain structures from magnetic resonance images (MRI) automatically. These methods need to be optimized, fine- tuned, and compared to other methods for the segmentation of specific brain structures that may be involved in medical temporal lobe epilepsy (mTLE). Feature extraction methods also need to be developed and optimized to characterize (i.e., determine local and global multi- parametric intensity distribution, texture, shape, surface area, surface curvatures, and volume of) the brain structures. Multi-modality analysis using multi-parametric MRI and SPEC needs to be developed for improved sensitivity and specificity. We have also developed our preliminary version of acontent-based human brain image database system to hold the image analysis results with other clinical information (e.g., textual data) in a manner that can be searched, retrieved, and queried conveniently from any computer station. This system needs integrated methods for data preparation, missing value treatment, interactive rule-extraction, visualization, and user- inference to serve as a decision support system in clinical practice. A user-friendly, web- based interface will be critical for the ultimate use of the system by researchers and clinicians. Last but not least, the database needs to be populated with data from alarge number of patients so that it can be confidently used for hypothesis testing and clinical applications. The goal of this project is to develop novel approaches for the above needs. Image analysis and feature extraction methods will segment and characterize hippocampus, amygdala, entorhinal cortex, thalamus, putamen, and other brain structures from MRI. The methods will be tested, evaluated, and validated using clinical data of epilepsy patients. Clinical diagnosis based on EEG studies and surgery outcome will be used as “god standards” for evaluation and validation of the image analysis methods.The proposed decision support system will be populated with multi-modality data of 350 epilepsy patients to evaluate correlation between a variety of risk factors, imaging features, clinical diagnosis (lateralization), and post-operative outcomes, and to assist physicians with improved clinical diagnosis, reduced intracranial EEG studies (reduced risk and suffering of patients as well as their

9 healthcare cost), optimal treatment options, and prediction of outcome in prospective studies. The proposed research will bea breakthrough inthe application of computerized methods for medical image quantification and object characterization, and will advance image analysis science in the direction of integrating knowledge-based image segmentation and characterization methods with pattern recognition and data mining technology in decision support systems. The proposed approaches are applicable to the identification, segmentation, and characterization of other biological structures. They are also applicable to virtually any image analysis task for which object segmentation, quantification, and characterization are used. This project will develop a decision support system for assisting physicians to improve diagnosis and prognosis of epilepsy patients while reducing the healthcare cost. It will process multi-modality medical images and extract quantitative information from them. The image analysis results will be used along with the results of other clinical tests as well as the patients’ history and characteristics to reduce the need for intracranial electrographic studies, predict post- operative outcomes, and suggest optimal treatment options for the newpatients.

Neurology

Principal Investigator: Meser Ali, Ph.D. Treatment of Glioma with Nanocombretastatin with MRI Monitoring (R01CA206190)

Glioblastoma (GBM) is a highly aggressive hypervascularized brain tumor characterized by high recurrence rates and poor prognosis despite advanced treatment. The vasculature of GBM is fundamentally different from that of normal vasculature and offers a unique target for anti-cancer therapy. Therefore, direct targeting of tumor vasculature with vascular disrupting agents (VDAs) is distinctly different from anti-angiogenic strategies,and offers a complementary approach to standard therapies. Combretastatin A4 (CA4) is a potent vascular disrupting drug. CA4 induces rapid shutdown of tumor blood supply, typically promoting a necrosis at the core of the tumor, but leaves a rim of viable tumor cells at the periphery which can then rapidly re-grow. However, CA4 is not effective in inducing necrosis at the core of GBM tumor. The ineffectiveness of small molecule chemotherapy drugs in treating malignant brain tumors has been attributed to the blood-brain barrier (BBB) being a significant impediment to the transvascular extravasation of drug fraction across the barrier into the extravascular compartment of tumor tissue and the high tumor interstitial fluid pressure also presents an additional delivery barrier. Nanotechnology is already benefiting to deliver drugs across the BBB and into brain tumors. We have engineered a nano-sized polymeric CA4 conjugate which demonstrates high water solubility. Preliminary intravenous (i.v.) delivery of G3-CA4 in an orthotopic glioma model demonstrated necrosis at the core of the tumor leaving a rim of viable tissue. By applying the designed nanoprodrug strategy and tumorspecific prodrug activation mechanism, we observed the true success of inducing necrosis at the core of the tumor in an orthotopic U-251 glioma animal model first time. Tumor-VDAs have significant potential when combined with cytotoxic chemotherapy and radiotherapy in treating other tumor models. Combined treatment with radiation is attractive, as radiation therapy (RT) represents a standard of care and RT should effectively kill the well- oxygenated cancer cells in the well-perfused tumor rim. We have shown that GBM cancer stem cells are sensitive to radiation exposure in culture and a single dose of 50Gy irradiation yielded necrosis in primary GBM rat model. Therefore, this study is extended to include SRS and standard cytotoxic temozolomide (TMZ) therapies with G3-CA4. We hypothesize that the combination of G3-CA4 with SRS and TMZ will show synergistic cytotoxic effect in clinical relevant primary GBM model. Our objectives of the proposed research are A) To incorporate CA4 molecules with dendrimer-based nanoparticles (G3-CA4) that demonstrates full solubility in aqueous media, B) To determine the efficacy and safety of small molecule CA4, CA4-P and G3-CA4 nanoprodrug in U251 glioma tumor model, C) To determine the efficacy and safety of G3- CA4 alone or in combination with SRS in primary GBM, D) To determine the efficacy and safety of a combined G3-CA4 and standard TMZ therapy in primary GBM model. The overall therapeutic effect from G3-CA4 alone or in combination with SRS/TMZ will be evaluated by image-guided MRI monitoring of long-term survival rats.

Principal Investigator: Jieli Chen, Ph.D. Neurorestorative Therapy of Stroke with HUCBC in Type Two Diabetic Mice (NIH 1R01NS083078)

Diabetes mellitus (DM) leads to a 3-4 fold higher risk of experiencing ischemic stroke. Hyperglycemia 10 and diabetes instigate a cascade of events leading to vascular endothelial cell dysfunction, increased vascular permeability and poor recovery after ischemic stroke. Diabetic animals exhibit more severely injured white matter (WM) than non-DM animals after stroke. There is also a differential response to treatment of stroke between DM and non- DM subjects. Effective therapy of stroke in the non-DM population may not necessarily transfer to the DM population, prompting the need to develop therapeutic approaches specifically designed to reduce neurological deficits after stroke in the DM population. Our preliminary data show that T2DM significantly decreases microRNA- 126 (miR-126) and Angiopoietin-1 (Ang1) expression in the circulation and in the ischemic brain of mice.Human umbilical cord blood cell (HUCBC) treatment of stroke in T2DM mice starting at 3 days after stroke significantly improves recovery of neurological function as well as increases miR-126 and Ang1 expression in the ischemic brain. Therefore, based on our robust preliminary data, we propose to use HUCBCs for the treatment of stroke in the T2DM mice and to investigate the role of intercellular communication via miR- 126 encapsulated within Exosomes/Microvesicles (EMVs) in mediating the therapeutic benefit on HUCBCs for ischemic stroke. This application includes three Aims. Aim 1 will test if miR-126 mediates HUCBC treatment induced neurorestorative effects after stroke in T2DM mice. We hypothesize that miR-126 mediates HUCBC treatment–induced vascular integrity, axonal outgrowth, and WM remodeling, and improves functional outcome after stroke in T2DM mice. Aim 2 will test whether miR- 126 generated by HUCBCs is transferred to brain endothelial cells (BECs) and parenchymal cells via EMVs. We hypothesize that HUCBCs secrete EMVs containing miR-126 which are taken up by BECs and parenchymal cells. Aim 3 will investigate whether miR-126 regulation of Ang1 promotes the HUCBC-induced neurorestorative effects after stroke in T2DM mice. We hypothesize that: 1) HUCBC treatment of stroke in T2DM mice increases Ang-1 signaling activity in the ischemic brain; 2) miR-126 regulates Ang1 expression and thereby regulates vascular remodeling, axonal outgrowth and oligodendrocyte survival and differentiation; 3) Restoration of Ang1 with an Ang1 mimetic peptide will rescue the neurorestorative effects of knockdown of miR-126 in HUCBC after stroke in T2DM mice. In this application, we are the first to propose that, generation of miR-126 encapsulated in EMVs by HUCBCs contributes to its robust therapeutic restorative effects and that miR-126 and its regulation of Ang-1 mediate HUCBC- induced neurovascular and WM remodeling, and thereby improve stroke functional recovery in T2DM mice. This proposal is highly clinically relevant and if successful, will significantly impact the treatment of diabetic and possibly all stroke patients.

Principal Investigator: Jieli Chen, Ph.D. MiR-126/ABCA1 Mediates Exosome Induced Neurorestorative Effects after Stroke in T2DM Mice (1R01NS099030)

Diabetes mellitus (DM) leads to a 3-4 fold higher risk of experiencing ischemic stroke. Stroke in type two DM (T2DM) patients and in animal models increases vascular and white matter (WM) damage in the ischemic brain, and stroke in T2DM patients has a distinct clinical pattern and a poor prognosis compared to non-DM stroke. Exosomes (Exo), are active nano size biological lipid containers, which transport regulatory genes and proteins between cells and form a major biological communication conduit, facilitating a plethora of biological responses. The regulatory molecules contained in the exosome include microRNAs (miRs), which regulate gene translation and play primary roles in mediating a vast range of biological functions. MicroRNA-126 (miR-126) is an angiogenic microRNA and primarily expressed in endothelial cells (EC). Specific conditional knockout of EC miR-126 (miR- 126EC-/-) mice have significantly worse functional outcome after stroke as well as decreased brain miR- 126 and ATP-binding cassette transporter A1 (ABCA1) expression. Exosomes derived from EC (EC- Exo) have a high level of miR-126. Based on our robust preliminary data, in this pioneering study, we propose that treatment of stroke with EC-Exo will enhance neurorestorative effects after stroke in T2DM mice, possibly, via the miR-126/ABCA1 signaling pathway. This application includes three Aims. Aim-1: To test the therapeutic effects of EC-Exo on cerebral ischemic stroke in adult male and female T2DM mice. Aim-2: To evaluate whether miR-126 mediates EC-Exo treatment induced neurorestorative effects, we will evaluate the therapeutic effects of treatment of stroke in specific conditional knockout of EC miR-126 (MiR-126EC-/-) and in non-miR-126 knockout control (miR-126fl/fl) T2DM mice with EC- Exo derived from miR-126EC-/- brain ECs (miR-126EC-/- EC-Exo) or EC-Exo derived from wild type miR-126fl/fl brain ECs (miR-126fl/fl-EC-Exo) on vascular and axonal/WM remodeling and neurological and cognitive functional outcome. Aim-3: To test whether ABCA1, an indirect target of miR-126, contributes to EC-Exo treatment induced neurorestorative effects after stroke in adult male T2DM mice, mice with specific knockout of brain ABCA1 (ABCA1-B/-B) and WT ABCA1 knockout control (ABCA1fl/fl) mice will be employed. In this application, we are the first to propose that, generation of

11 miR-126 encapsulated in EC-Exo contributes to its robust therapeutic restorative effects and that miR- 126/ABCA1 pathway mediates EC-Exo-induced neurovascular and WM remodeling, and thereby improves stroke neurological and cognitive functional recovery in T2DM mice. This proposal is highly clinically relevant and if successful, will significantly impact the treatment of diabetic stroke, and possibly all stroke patients.

Principal Investigator: Michael Chopp, Ph.D. miR-17-92 Exosome Treatment of Stroke (NIH R01NS088656)

Exosomes, small lipid microvesicles (30-150 nm), are active biological containers, which transport regulatory genes and proteins between cells and form a major biological communication conduit, facilitating a plethora of biological responses. The regulatory molecules contained in the exosomes include microRNAs (miRNAs), short (22-25 nt) non-coding RNAs which regulate gene translation and play primary roles in mediating a vast range of biological functions. In this proposal, based on strong preliminary data, we propose to manufacture a distinct exosome population which contains increased levels of the miR- 17-92 cluster as a proof-of-principle and a mechanistic demonstration of a new method of treating stroke and possibly other neurological diseases and injury. We test the premise, that by modulating their miRNA content, exosomes can be designed to enhance plasticity of axons and thereby further promote neurological recovery post stroke. Success of this novel approach may lead to a new designer-based paradigm for the treatment of stroke and neurological disease. The following Specific Aims and associated Hypotheses are proposed: Specific Aim 1: To employ exosomes derived from multipotent mesenchymal stromal cells (MSCs) to treat stroke in order to enhance neurovascular remodeling and thereby, functional recovery post stroke. Hypothesis: Exosomes, derived from MSCs when administered to rats after stroke promote neurovascular remodeling which improves functional outcome. Specific Aim 2: To alter specific miRNAs contained within exosomes generated by MSCs as a means to enhance axonal plasticity and neurological recovery post stroke. Hypothesis: Administration of exosomes with increased miR-17-92 cluster to rats post stroke promotes axonal remodeling and enhances functional outcome. There are multiple layers of innovation in our application: we generate biological exosome carriers tailored for specific miRNAs; we use these exosomes to treat stroke, without the administration of exogenous cells; we employ electrophysiological methods, laser capture, fiber track tracing, a battery of neurological tests, and an array of novel approaches, e.g. microfluidic chambers, and ex vivo slice cultures, to mechanistically determine the molecular pathways of the target exosomes which mediate axonal outgrowth. Development of this designer exosome-based therapy, also serves as a prototype for capitalizing on the characteristics of exosomes to transport specific miRNAs and for the manufacture of designer exosomes. Developing a therapy for stroke that is exosome- based, opens up a wide variety of means to deliver targeted regulatory genes to enhance multifaceted aspects of central nervous system (CNS) plasticity and to amplify neurological recovery for neural injury and neurodegenerative diseases.

Principal Investigator: Xu Cui, Ph.D. ABCA1 Regulates White Matter Remodeling and Oligodendrogenesis after Stroke (NIH R01NS092917)

Stroke is a major cause of white matter (WM) damage which induces long-term disability. There is limited WM remodeling in the adult brain. Many neuroprotective treatments of stroke have failed in clinical trials because they cannot protect WM. Therefore, there is a compelling need to investigate the mechanism underlying WM remodeling and oligodendrogenesis of the adult brain and to develop effective long-term stroke therapy. Cellular cholesterol modulates axonal and dendritic outgrowth and is required for myelination. The level of HDL-cholesterol is related to the progression and recovery of stroke patients. ATP-binding cassette transporter A 1 (ABCA1) is a major cholesterol transporter and plays critical roles in regulation of HDL- cholesterol and ApoE synthesis and metabolism in the central nervous system. Brain specific- ABCA1 deficient (ABCA1-B/- B) mice have very low brain HDL-cholesterol/ApoE level, and exhibit neuronal ultrastructure changes and functional deficits. Both HDL-cholesterol and ApoE increase neurite outgrowth in culture conditions. Our preliminary study shows that ABCA1-B/-B mice exhibited increased WM damage and reduced oligodendrogenesis and exacerbated neurological functional deficits after

12 stroke. Primary cultured neurons derived from ABCA1- B/-B mice show decreased neurite outgrowth, which can be attenuated by HDL treatment. ABCA1-B/-B astrocyte-conditioned media also decreased wild type neurite outgrowth after hypoxic ischemia. Therefore, we propose the following three specific aims: Aim1 To investigate whether brain-deficient in ABCA1 exhibits decreases in WM-remodeling and axonal growth after stroke. ABCA1-B/-B and floxed-control mice will be subjected to stroke, WM-changes and oligodendrogenesis will be measured. Aim2 To investigate molecular mechanism underlying ABCA1 in regulation of WM-remodeling and oligodendrogenesis after stroke, we will examine whether ABCA1 regulates brain HDL and ApoE level, and whether brain HDL and ApoE levels mediate ABCA1-induced WM-remodeling and oligodendrogenesis after stroke. Aim3 To investigate cellular mechanisms of ABCA1 in regulation of WM- remodeling and oligodendrogenesis, we will examine neurons and oligodendrocytes and the cross talk of astrocytes with neurons and oligodendrocytes on ABCA1-induced WMremodeling and oligodendrogenesis in vitro and in vivo. We expect that ABCA1 deficient brain will exhibit significant decreases in HDL and ApoE level, and decreases WM-remodeling and oligodendrogenesis as well as reduced functional outcome after stroke. The level of HDL/ApoE in brain or cerebrospinal fluid will, at least partially, mediate ABCA1-induced WM-remodeling and oligodendrogenesis in the ischemic brain after stroke. To our knowledge, no one has investigated the functional effect of ABCA1 on oligodendrogenesis and WMremodeling post- stroke recovery, especially by using ABCA1- B/-B mice. The new insights gleaned from this study will contribute to our understanding of the beneficial role of ABCA1/HDL-C/ApoE in brain plasticity which will impact development of rational restorative approaches to improve neurological outcome for stroke patients.

Principal Investigator: Quan Jiang, Ph.D. Impairment of the Glymphatic System in the Aged Diabetic Brain (R21AG052735)

Type II diabetes mellitus (T2DM) is a common metabolic disease and an established risk factor for cognitive dysfunction in the elderly population. However, the pathological mechanisms that underpin the development and progression of DM-related deficits remain unclear. Recent investigations1-4 have altered the traditional model of cerebrospinal fluid (CSF) hydrodynamics. The brain lacks specialized organ-wide anatomic structure to facilitate lymphatic clearance although the brain has complex architecture and high metabolic activity. However, a newly identified glymphatic system has been shown to modulate the CSF-interstitial (ISF) exchange, which facilitates clearance of interstitial solute from the brain parenchyma. Impairment of the glymphatic system is involved with the development of neurodegenerative conditions, including Alzheimers disease and sleep disorders, etc2, 4. Although the impact of the glymphatic system is being investigated in Alzheimers disease and sleep disorders, with promising results, there are no reported data related to diabetes and the glymphatic system. Using a model of T2DM in middle- aged rats and noninvasive MRI methodologies, our preliminary data indicate that compared with age-matched non-DM rats, the T2DM rats reduced clearance rate of interstitial Gd- DTPA agent from brain parenchyma by approximately 84 % and increased clearance time by 4.2 time of Non- DM rats in the hippocampus, leading to accumulation of Gd-DTPA agent in these regions and consequently high MRI signal intensity in T1 weighted MRI (T1WI). In parallel, ex-vivo confocal imaging analysis revealed that in Non-DM rats, the concentration of interstitial Texas Red-conjugated dextran (TR-3, MW 3kD) reached a plateau in the brain interstitium approximately 3h after injecting TR-3 into the cisterna magna and after that TR-3 began to clear and was almost completely cleared from brain parenchyma at 6h after the injection, whereas in middle-age T2DM rats TR-3 accumulated in the hippocampal interstitium with time and exhibited strong fluorescent signals at 6h after the injection. These ex-vivo data are consistent with in vivo MRI findings, indicating that T2DM impairs the glymphatic clearance of interstitial solutes in the brain. In addition, T2DM rats exhibited microvascular thrombosis and blood brain barrier (BBB) leakage in the hippocampus in immunofluorescent analysis and also showed spatial learning deficits compared to Non-DM rats. Based on our novel preliminary data, we will employ MRI and 3D confocal microscopy to evaluate for the first time, temporal and spatial profiles of paravascular CSF-ISF exchange throughout the brain during the development of T2DM. We propose to further develop MRI protocol and analysis modeling as an effective means to evaluate the function and status of the glymphatic system (Aim 1). We will then use the optimized MRI protocol and analysis to explore the relationships between impairment of glymphatic system, vascular damage, and functional deficits during develop of DM (Aim 2). Data generated from this application will provide new insights into the progression of DM associated impairment of the glymphatic system.

13 Principal Investigator: Xianshuang Liu, M.D. Translational Study of miR-146a Gene Therapy for Diabetic Peripheral Neuropathy (NIH R01DK102861)

Peripheral neuropathy is the major complications of diabetes. There is a compelling need to develop effective therapeutic approaches specifically designed to improve neurological function in the damaged peripheral nervous system after diabetes. MicroRNA-146a (miR- 146a) has been implicated in the regulation of multiple immune diseases. However, the role of miR-146a in diabetic peripheral neuropathy (DPN) has not been investigated. In a novel set of experiments, our preliminary data show that intravenous administration of miR-146a remarkably improved sciatic nerve vascular function, axonal myelination and peripheral nerve function in diabetic mice, indicating that miR-146a may have a beneficial effect on the clinical treatment of DPN. In this application, we therefore seek to investigate the mechanisms underlying the therapeutic effects of miR-146a on DPN. We propose that miR- 146a by improving vascular function and suppressing pro-inflammation factors ameliorates DPN. The associated hypotheses are: 1. Treatment with chemically engineered miR-146a improves neurological outcomes in DPN in dose and therapeutic window dependent manners. 2. Elevation of miR-146a levels suppresses its target genes, IRAK1/TRAF6 and their down-stream pro-inflammatory factors in vascular endothelial cells and monocytes of type II diabetic mice, thereby, leading to the improvement of neurovascular function and consequently ameliorating peripheral neuropathy. To investigate the effect of miR-146a on neurological outcomes, type II diabetic mice which develop severe peripheral neuropathy will be treated with miR-146a at various time points and doses after onset of DPN. To investigate the underlying molecular mechanisms, the effects of miR-146a overexpression and knockdown on target genes and inflammatory genes that mediate miR- 146a-enhanced neurovascular function will be determined. These studies are innovative and will provide novel insights into mechanisms underlying the neurological dysfunction of DPN and likely lead to the development of a new miRNA-based gene therapy.

Prinicipal Investigator: LeiWang, M.D. Thymosin Beta4 Promotes the Recovery of Peripheral Neuropathy in Diabetic Mice (NIH R01DK097519)

Peripheral neuropathy is one of the major complications of diabetes. There is a compelling need to develop effective therapeutic approaches specifically designed to improve neurological function in the damaged peripheral nervous system after diabetes. Thymosin Beta4 (Tβ4), a major intracellular G-actin sequestering peptide, has multiple biological functions, including promotion of remodeling of injured and damaged tissues, and increasing angiogenesis after myocardial infarction. However, the role of Tβ4 in diabetic peripheral neuropathy has not been investigated. In a novel set of experiments, our data show that Tβ4 remarkably improved sciatic nerve vascular function and peripheral nerve function in diabetic mice, indicating that Tβ4 may have a beneficial effect on the clinical treatment of diabetic peripheral neuropathy. In this application, we therefore seek to investigate the mechanisms underlying the therapeutic effects of Tβ4 on the treatment of diabetic peripheral neuropathy. We propose that Tβ4 by improving vascular function ameliorates diabetic peripheral neuropathy. Our hypotheses are: 1. Treatment with Tβ4 improves neurological function of peripheral neuropathy in diabetic mice. 2. The Ang/Tie2 signaling pathway mediates the therapeutic effect of Tβ4 on neurovascular function in diabetic peripheral neuropathy. 3. The PI3K/Akt signaling pathway underlies the effect of Tβ4 on Ang1/Ang2 expression. To investigate the effect of Tβ4 on neurological outcome, type II diabetic mice which develop severe peripheral neuropathy will be treated with Tβ4 at various time points after onset of diabetes. To investigate the molecular mechanisms that mediate Tβ4–enhanced neurovascular function in diabetic mice, the effect of Tβ4 on expression of Ang/Tie2, and activation of PI3K/Akt signaling pathway will be examined. Using pharmacological inhibitors and siRNA gene knockdown techniques, we will investigate the cause-effect of the Ang/Tie2 and PI3K/Akt signaling pathways on regulating Tβ4-enhanced neurovascular function and axonal outgrowth. These studies are innovative and will provide new insight into mechanisms underlying the neurological dysfunction of diabetic peripheral neuropathy and lead to the development of a new treatment using Tβ4.Peripheral neuropathy often stemming from diabetes is a major disability affecting millions of Americans. In this proposal, employing preclinical studies in the diabetic animal, I seek to develop a novel treatment for peripheral neuropath using Tβ4. Tβ4 is currently in a phase II clinic trial for the treatment of patients with acute myocardial infarction. In this proposal, I also elucidate the molecular mechanism by which Tβ4 is therapeutically effective. This research will provide the essential pre-clinical data for translation to a

14 phase 1 clinical trial.

Principal Investigator: Hongqi Xin, Ph.D. Exosome Transfer of miR-133b Mediates MSC Induced Neurological Recovery after Stroke (NIH R01NS081189)

Multipotent mesenchymal stromal cells (MSCs) have potential therapeutic benefit in many diseases including neurological diseases and injury. MSC-based therapies enhance recovery from stroke. We have previously demonstrated that exogenously administered MSCs interact with neural cells, increase the production of neurites, reduce expression of axonal inhibitory molecules and stimulate the production of growth and plasticity positive factors in neural cells which promote neurorestoration and recovery of neurological function. However, it is unknown how MSCs interact with neural cells, alter their protein expression, and thereby promote functional recovery. In the present proposal, we provide fundamental and novel mechanistic insight into how cell-based therapies promote recovery. MicroRNAs (miRNAs) act as master switches regulating the translation of many genes, and exosomes are membrane vesicles, 40-100nm in diameter, that are secreted by a wide range of cell types. We propose that MSCs increase specific miRNA levels in neural cells via exosomes, which subsequently stimulate neurite outgrowth and functional recovery. Based on our preliminary data, we will primarily focus on miR-133b, as an important target miRNA. Two specific aims are proposed. Aim 1: To investigate whether exosomes primarily mediate cell-cell communication by direct transfer of miR-133b to neural cells and/or indirectly by stimulating miR-133b expression in neural cells, which subsequently promote neurite outgrowth and functional recovery after stroke. Aim 2: To investigate the mechanisms by which miR- 133b promotes neurite remodeling after treatment of stroke with MSCs. This study opens up important and novel ways to elucidate how exogenously administered cells communicate with and alter neural cells to activate restorative events. Confirming our hypothesis represents a major leap forward in our understanding of cell-cell communication and will lead to novel ways to augment brain recovery.

Principal Investigator: Zheng Gang Zhang, M.D., Ph.D. MicroRNAs and Neurogenesis after Stroke (NIH 1R01NS075156)

MicroRNAs (miRNAs) regulate biological function of neural progenitor cells and oligodendrocyte progenitor cells (OPCs). Our preliminary data show that stroke substantially changed miRNA expression profiles in adult neural progenitor cells and oligodendrocytes. In this application, we propose to test the hypothesis that miRNAs in neural and OPCs play a pivotal role in mediating adult neurogenesis and oligodendrogenesis in the ischemic brain. In Specific Aim 1, we will investigate the effect of inactive miRNA processes in neural progenitor cells and OPCs on stroke-induced neurogenesis and oligodendrogenesis by conditional and inducible Dicer ablation in Ascl1 lineage cells (Ascl1- reTM/Dicerflox/flox). In Specific Aim 2, we will investigate whether the sonic hedgehog (Shh) signaling pathway interacts with the miR- 17-92 cluster to increase neurogenesis and oligodendrogenesis. In Specific Aim 3, we will investigate the effect of the miR17-92 cluster on biological function of neural and oligodendrocyte progenitor cells in the ischemic brain by deletion or overexpression of the miR17-92 cluster in neural progenitor cells and OPCs after stroke. These studies will provide novel insights into miRNAs in regulating stroke-induced neurogenesis and oligodendrogenesis, which could potentially lead to new therapies to amplify neurogenesis and oligodendrogenesis in injured brain. Neurogenesis and oligodendrogenesis are associated with functional recovery after stroke. Molecular mechanisms underlying generation of new neurons and oligodendrocytes in ischemic brain have not been fully understood. Our preliminary data suggest that MicroRNAs (miRNAs), short noncoding RNA molecules, could be essential components in mediating stroke-induced neurogenesis and oligodendrogenesis. In this application, we propose three experiments to investigate the role of miRNAs in regulating adult neurogenesis and oligodendrogenesis in the ischemic brain. We will first delete Dicer to inactive miRNA processes in neural progenitor cells and oligodendrocyte progenitor cells (OPCs) after stroke. We will then examine a linkage between the sonic hedgehog (Shh) signaling pathway and miR17-92 expression in mediating neurogenesis and oligodendrogenesis. Finally, we will ablate or overexpress the miR17-92 cluster in neural progenitor cells and OPCs. These studies will provide novel insights into miRNAs in regulating stroke- induced neurogenesis and oligodendrogenesis, which could potentially lead to new therapies to amplify neurogenesis and oligodendrogenesis in injured brain.

15 Principal Investigator: Zheng Gang Zhang, M.D., Ph.D. Ac-SDKP for Treatment of Acute Stroke (NIH R01NS079612)

Stroke is a leading cause of death and disability worldwide and approximately 72% of people who suffer a stroke are over the age of 65. Tissue plasminogen activator (tPA) is the only drug approved by the Food and Drug Administration (FDA) for treatment of acute stroke (within 4.5h). The most feared complication after tPA treatment of stroke is an increased risk of cerebral hemorrhage. Our preliminary data indicate that N- acetylseryl- aspartyl-lysyl-proline (Ac-SDKP), a peptide normally presented in human plasma, in combination with tPA reduced infarct volume by more than 50% and improved neurological outcome, but did not increase the incidence of hemorrhagic transformation in young adult rats. In this application, we propose to develop a combination therapy of Ac- SDKP and tPA for treatment of acute stroke in aged rats and to investigate molecular mechanisms underlying the combination therapy on the neurovascular unit. In Specific Aim 1, using MRI and 3D laser confocal microscopy, we will investigate the effect of Ac-SDKP alone and Ac-SDKP in combination with tPA on recanalization of the occluded MCA, cerebral microvascular perfusion and vascular integrity, brain hemorrhage, and ischemic neuronal damage in aged rats subjected to embolic middle cerebral artery occlusion (MCAO). In Specific Aim 2, we will examine whether Ac-SDKP suppresses the ischemia- and tPA-activated nuclear transcription factor-κB (NF-ĸB) pathway in cerebral vessels, which leads to enhancement of cerebral microvascular patency and integrity by reduction of thrombosis. In Specific Aim 3, we will examine whether Ac-SDKP blocks the ischemia- and tPA-activated transforming growth factor β (TGFβ) signaling pathway in cerebral vessels and astrocytes, which leads to reduction of thrombosis by down regulation of plasminogen activator inhibitor1 (PAI- 1). These studies could potentially provide a new therapy to minimize the adverse effect of tPA on ischemic neurovascular damage, leading to improved neurological outcomes after acute stroke.

Pathology

Principal Investigator: Chunhai (Charlie) Hao, M.D. SUMO1 Inhibition Compound as a New Anticancer Drug for Glioblastoma Therapy (R01CA20389301)

Our long term goal is to develop novel and effective treatments of glioblastoma, the most common and lethal human brain cancer. To achieve this goal, we propose to develop the SUMO1 inhibition compound (SMIC1) as a new anticancer drug for glioblastoma therapy. In our recent studies, we have demonstrated for the first time that SUMO1 modification is overactive in human glioblastoma and drives the cell cycle and tumor growth through its conjugation of the cell cycle control protein termed cyclin- dependent kinase-6 (CDK6). SUMO1- CDK6 conjugation inhibits CDK6 ubiquitination and the ubiquitin- mediated proteolysis, thus stabilizes CDK6 protein and kinase activity and drives the cell cycle for glioblastoma progression. To target this pathway in glioblastoma, we designed and carried out the tumor cell-based screening of NCI pharmacological compounds. The screening led to the discovery of a SUMO1-specific inhibitor that we named and patented as the SUMO1 inhibition compound (SMIC1). In preliminary studies, we have shown that SMIC1 is rapidly absorbed into the system circulation and distribution in brain tissues through the blood brain barrier after administration in animal models. SMIC1 treatment blocks SUMO1-CDK6 conjugation and suppresses the progression of glioblastoma cells and xenograft animal models. These preliminary data indicate the potential of SMIC1 in the treatment of human glioblastoma. To develop this potential of SMIC1, we will follow the US Food and Drug Administration guidance in nonclinical evaluation of anticancer pharmaceuticals. In Aim 1, we will examine the pharmacology, i.e. mechanism of action of this new drug in treating glioblastoma cells. In preliminary studies, we have shown that SMIC1 treatment eliminates SUMO1 protein through its ubiquitination and degradation. In this study, we will further identify the ubiquitination site on SUMO1 protein and the ubiquitination regulatory enzyme that is targeted by the drug. These studies will test the hypothesis that through induction of the ubiquitination and degradation of SUMO1 protein, SMIC1 treatment inhibits SUMO1-CDK6 conjugation and blocks the cell cycle progression in glioblastoma cells. In Aim 2, we will test the drug toxicology and pharmacokinetics. Through the analyses, we will identify a dose window in which SMIC1 can effectively inhibit SUMOylation and tumor growth without causing any damage to normal tissues. The data will provide valuable information in dose selection and schedule for clinical trails of SMIC1 treatment of cancer patients. In Aim3, we will evaluate the therapeutic efficacity of this new drug in treating the cancer stem cells-derived xenograft models of human glioblastoma and

16 determiner whether SMIC1 treatment can effectively suppress the tumor progression. Upon completion, this proposal will lead to the genesis of a new anticancer drug for clinical treatment of patients suffering this deadly human cancer.

Radiation Oncology

Principal Investigator: Mohamed Elshaikh, M.D. Molecular Classification of High Grade Endometrial Cancers: Extending TCGA Findings to a High Risk Population (NIH R01CA2000864)

To update the Henry Ford Health System database for patients with endometrial cancer that includes more than 1,900 women in regards to the different prognostic factors including treatment factors in addition to survival data, Additionally, to identify the patterns of recurrence for those who receive no treatment after surgery compared to those who received radiation treatment, chemotherapy or a combination of both, To identify patients who are at higher risk for recurrence based on the known prognostic factors. To conduct data analysis and reporting of the results.

Principal Investigator: Svend Freytag, Ph.D. Gene Therapy and Radiation Therapy for Prostate Cancer (NIHR01CA160289)

Our translational research program has been developing a multi-modal, gene therapy- based approach for the treatment of cancer. We have evaluated the toxicity and preliminary efficacy of our investigational approach in five clinical trials of non-metastatic prostate cancer. Our early stage results indicate that our approach is safe and has the potential to improve local tumor control. Although local tumor control is important, new therapies for high-risk prostate cancer must also target metastatic disease if they are to have an impact on survival. Hence, we have added a fourth modality to our investigational approach by generating a third-generation adenovirus armed with interleukin 12 (IL-12) that has the potential to eradicate both local and metastatic disease. This new adenovirus has generated encouraging preliminary results in preclinical studies, and we plan to move it into the clinic targeting high-risk prostate cancer. In specific aim 1, we will test the hypothesis that IL-12 will improve the efficacy of replication- competent adenovirus-mediated suicide gene therapy and radiation in an immune- competent, orthotopic model of prostate cancer. C57BL/6 male mice bearing intraprostatic TRAMP-C2 tumors will receive an intratumoral injection of Ad5- yCD/mutTKSR39rep-mIL12 followed by 2 weeks of 5-fluorocytosine (5- FC) + ganciclovir (GCV) prodrug therapy and pelvic radiation. Primary endpoints are local and metastatic tumor control. Secondary endpoints include T cell activation, NK and CTL activity, serum and tumor cytokine levels, and development of anti-tumor immunity. In specific aim 2, we will test the hypothesis that cyclophosphamide (CP) can be combined safely with replication-competent adenovirus-mediated suicide and IL-12 gene therapy and that the combined therapies exhibit synergy in vivo. Efficacy will be examined in the immune-competent, orthotopic TRAMP-C2 tumor model without and with CP. Efficacy endpoints are identical to those in specific aim 1. Toxicity will be examined in C57BL/6 male mice and Syrian hamsters, the latter of which are permissive for human adenovirus replication. In specific aim 3, we will test the hypothesis that replication- competent adenovirus-mediated suicide and IL-12 gene therapy can be combined safely with intensity modulated radiation therapy (IMRT) and androgen suppression therapy (AST) in men with newly-diagnosed, high-risk prostate cancer. Fifteen men (5 cohorts, 3 patients each) with high-risk prostate cancer (Stage e T3 or Gleason e 8 or PSA >20 ng/mL) will receive a single injection of Ad5- yCD/mutTKSR39rep-hIL12 at five dose levels (1 x 1010 vp to 1 x 1012 vp in half- log increments). The adenovirus will be injected intraprostatically under transrectal ultrasound- guidance. Two days later, men will receive 2 weeks of 5-FC + valganciclovir (vGCV) prodrug therapy concomitant with 80 Gy IMRT and e 2 years of AST. The primary endpoint is toxicity through day 90. Secondary endpoints are: 1) prostate biopsy at 2 years, 2) freedom from biochemical/clinical failure (FFF), 3) disease-specific survival, 4) overall survival, and 5) serum cytokine levels. We believe this research will have high impact because it may lead to better treatments for aggressive forms of prostate cancer. Public Health Relevance: The broad, long-term goal of the proposed research is to develop better cancer treatments. This research will improve further an investigational therapy that has already demonstrated promising activity in early stage 17 trials of prostate cancer. We believe this research will have high impact because it will lead to better treatments for aggressive forms of prostate cancer.

Principal Investigator: Carri Glide-Hurst, Ph.D. Development of Anatomical Patient Models to Facilitate MR-only Treatment Planning (NIH 1R01CA204189)

Accurate delineation of targets and organs at risk for radiation therapy planning (RTP) remains a challenge due to the lack of soft tissue contrast in computed tomography (CT), the standard of care imaging for RTP. Radiation Oncology has addressed this limitation by registering magnetic resonance images (MRI) to CT datasets to take advantage of the superior soft tissue contrast afforded by MRI. MRI brings considerable value to RTP by improving delineation accuracy which, in turn, has enabled dose escalation to improve local control while maintaining or reducing normal tissue toxicities. However, the current integration of MRI as an adjunct to CT has significant drawbacks as it requires image registration and contour transfer between datasets. This process introduces systematic geometric uncertainties that persist throughout treatment and may compromise tumor control. Thus, we propose to translate MR-only RTP into clinical use, with the ultimate goal of improving patient outcomes accomplished via improved treatment plan design. MR-only RTP will eliminate redundant CT scans (reducing dose, patient time, and costs), streamline clinical efficiency, entirely circumvent registration uncertainties, and fully exploit the benefits of MRI for high-precision RTP. Yet, MRI is not routinely used alone for RTP, largely due to its known spatial distortions, lack of electron density, and inability to segment the bone needed for online image guidance and electron density mapping for dose calculation. The central hypothesis is that the innovative technologies that our multi- disciplinary academic/industrial (Henry Ford Health System/Philips Healthcare) collaboration develop will yield geometrically accurate patient models built from MRI data across several platforms/field strengths with CT-equivalent densities that can be used in confidence throughout the entire RTP workflow. In Aim 1, we will perform geometric distortion corrections, determine distortion variability with changing anatomy, benchmark the results in a novel modular phantom, and develop an image processing toolkit. In Aim 2, we will fully automate MR image segmentation in the brain and male/female pelvis to yield accurate synthetic CT patient models derived from novel MRI sequences, including provisions for metal implants, and benchmark the results in phantom. In Aim 3, we will conduct end-to-end testing to characterize the uncertainties in the MR-only RTP workflow. We will perform a virtual clinical trial of MR-only RTP for brain and male/female pelvis and compare to the standard of care. Final translation will include developing physician-physicist practice guidelines, end-user validation of all translational steps, and dissemination of image processing tools into the Radiation Oncology community. This research will systematically address the major challenges limiting MR-only RTP and lay the groundwork for multi- institutional clinical trials across MRI platforms. It will support future work related to MR-guided RT, functional MRI for biologically adaptive RT, and focal RT to areas of high tumor burden.

Surgery

Principal Investigator: Jeffrey Johnson, M.D. ATB-202: A Phase III, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Study of AB103 as Compared to Placebo in Patients with Necrotizing Soft Tissue Infections (NSTI) (HHSO1002014000013C)

The purpose of this study is to determine whether AB103 is safe and effective in the treatment of patients with necrotizing soft tissue infections receiving standard of care therapy.

The primary hypothesis of this study is that in addition to standard of care treatment (which includes surgical intervention, antimicrobial therapy and critical care support for organ dysfunction or failure), AB103 will demonstrate a clinically significant treatment benefit over placebo.

18 Urology

Principal Investigator: Nallasivam Palanisamy, Ph.D. Comprehensive Molecular Profiling of Prostate Cancer in African American Population; Unraveling Molecular Heterogeneity (Dept. of Defense W81XWH-16-1-0544)

Prostate cancer is a complex disease with multiple tumors originating independently at different stages of growth. Although morphological differences has been well recognized, the underlying molecular complexity in each tumor foci has not been well studied. Tumor growth in each foci can be determined by independent driver molecular aberration(s). Understanding the molecular level of differences in each tumor foci would help to differentiate the patients who may undergo indolent or aggressive disease course. Further, morphological differences mostly help to understand the stage of the disease, but it is not possible to select appropriate targeted therapy. If different tumor foci carry different driver molecular aberrations, targeted therapy for single molecular aberrations may not yield the curative benefit to the patients. Conventionally, systematic sampling of large tumor foci or high Gleason grade tumor foci have been considered for various genetic and molecular studies. In this approach smaller tumor foci with important driver molecular aberration and high metastatic potential can be easily missed. Therefore, using our novel approach, we propose to screen the entire prostate tissue to assess molecular differences in each tumor foci using well characterized prostate cancer specific molecular markers.

19 Part III – Population and Health Sciences

• Center for Health Policy and Health Services Research • Department of Public Health Sciences

Center for Health Policy and Health Services Research

Principal Investigator: Brian Ahmedani, Ph.D. Treatment Utilization Before Suicide (TUBS) (NIH R01MH103539)

Adult suicide rates in the United States rose by almost 30 percent between 1999 and 2010. These rates have not markedly improved in decades. To date, previous suicide attempts and psychiatric diagnoses are largely the only known clinical risk factors for suicide death. Recent research shows that most individuals who die by suicide make a health care visit in the weeks and months prior to their death. Most of these visits occur in primary care or outpatient medical specialty settings. However, over half of these visits do not include a psychiatric diagnosis.

Thus, there is limited evidence available from health care users in the US general population to inform targeted suicide screening and risk identification efforts in general medical settings. New research is needed to investigate the general medical clinical factors associated with increased suicide risk among individuals without a known risk factor. This research project uses data on more than 4000 individuals who died by suicide and made health care visits to one of eight health care systems across the United States in the year prior to their death. These health systems are members of the Mental Health Research Network and have affiliated health plans. They are able to capture nearly all health care for their members via the Virtual Data Warehouse (VDW). The VDW consists of electronic medical record and insurance claims data organized using standardized data structures and definitions across sites. These data are matched with official regional mortality data. This project includes the following specific aims: 1) identify clinical factors from general medical visits prior to suicide across sites, 2) compare clinical factors to a matched sample of health care users across sites, and 3) investigate indications of psychiatric and other concerns in general medical chart notes prior to suicide. This is the first study with a large enough sample in the US general population to be able to study general medical treatment utilization prior to suicide death. This project will allow the identification of previously unknown factors that increase risk of suicide death, including general medical diagnoses, medications, health care procedures, and types of visits. These results will inform decisions about how to focus suicide prevention efforts in general medical settings.

Principal Investigator: Brian Ahmedani, Ph.D. ER/LA Opioid Post-Marketing Requirement Studies: Observational Study (FDA 1A 2065)

Estimate incidence of misuse, abuse, and addiction among patients treated longterm with ER/LA opioids for chronic pain overall and by the following factors: a) Clinical characteristics, product/formulation, dose and duration of opioid use, prescriber specialty, indication, and other clinical factors (e.g., concomitant psychotropic medications, personal or family history of substance abuse, history of psychiatric illness). b) Demographic factors, psychosocial/behavioral factors, medical factors, and genetic factors.

Principal Investigator: Jordan Braciszewski, Ph.D. Promoting Smoking Cessation Among Youth Exiting Foster Care (NIH R21CA205190)

Each year, roughly 30,000 youth exit the foster care system due to “aging out” at age 18, losing access to support services while also becoming fully responsible for their own financial, health, employment, and housing needs. Progressing from homes disproportionately high in neglect and maltreatment, these emerging adults face independence with an increased likelihood of heavy tobacco use and, ultimately, the development of tobacco use disorders. Indeed, lifetime tobacco use 20 is nearly ubiquitous among foster youth, while daily use rates are four times that of the general population. Services to curtail such use while young people remain in the foster care system are severely limited, if they are offered at all. Once removed from foster care, these youth have far less access to health services compared to their non-foster care peers. The proposed feasibility study seeks to address these gaps in availability, accessibility, and use of tobacco cessation services for youth aging out of the foster care system.

Computer- and mobile phone-based interventions have the capacity to provide evidence-based treatment content while reducing many of the barriers relevant to tobacco cessation service delivery for foster youth. The proposed study will begin a program of research to synthesize the benefits of these approaches in a way that addresses the needs of a vulnerable population who experience tobacco-related health disparities. More specifically, this study seeks to test an adaptation of an existing substance use intervention (iHeLP: Interactive Healthy Lifestyle Preparation) for smoking cessation among youth aging out of foster care. Rooted in motivational interviewing, the transtheoretical model, and social cognitive theory, iHeLP is a one-time computerized screening and brief intervention (SBI), supplemented by six months of tailored text messaging based on participants’ SBI results and subsequent fluctuations in their readiness to change. The goal of this pilot study is to obtain data on acceptability and feasibility of a novel intervention, as well as examine direction of effects on both overall motivation to change and actual tobacco use. As such, we will conduct a two-arm feasibility trial, testing iHeLP against a contact-control condition. The use of daily text messaging represents a novel method for delivering intervention boosters. Low-intensity, high-frequency interactions are a marked change from traditional interventions and have high potential for extending initial gains. In addition, tailoring of these messages through dynamic, text-based communication with participants is innovative. Given the potential of wide dissemination to multiple at-risk populations at low cost, the proposed study has high potential public health and clinical significance.

Principal Investigator: Keoki Williams, M.D. Combined Transcriptomics and Genomics to Find Asthma Genes in Admixed Populations (NIH R01HL118267)

African American individuals are more likely to develop asthma and are nearly three times as likely to experience serious asthma complications when compared with European American individuals. Genome wide association studies have identified a number of genetic risk markers for asthma, but many of the associations observed in European and European American patients have not replicated in African American individuals. This may be the result of allele frequencies, linkage disequilibria, or disease- related genes which differ by ancestry. Detailed characterization of the transcriptome can aid in the identification of asthma-related genes by circumventing some of the aforementioned problems associated with genotype association alone. Therefore, this proposal seeks to combine transcriptomics and genomics to identify asthma-related genes and the expression quantitative trait loci (eQTL) which appear to regulate these genes. We propose using RNA sequencing (RNA- seq) to characterize the transcriptome of African American individuals with and without asthma. RNA-seq is superior to traditional microarrays at quantifying transcript abundance, but this method has not been widely used in U.S. minority populations to date. The Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-ethnicity (SAPPHIRE) cohort is an ideal group in which combine these analytic approaches. In addition to being one of largest and best characterized asthma cohorts in the U.S., genome wide genotype data and banked whole blood RNA already exist for a large number of SAPPHIRE participants. In Specific Aim 1, we will use RNA-seq to identify expression differences in previously identified asthma-related genes among African American individuals by asthma status. Pre- existing genotype data will then be used to identify eQTL for these differentially expressed, asthma-associated genes. In Specific Aim 2, we will use admixture mapping to identify chromosomal regions where ancestry is associated withasthma. The genes in these regions will be interrogated for differential expression by asthma status. The resulting potentially novel, ancestry-specific asthma genes will also be assessed for eQTL. As a subset of African American SAPPHIRE participants have RNA collected at both their initial evaluation and the time of an asthma exacerbation, in Specific Aim 3 we will assess whether the genes identified in the preceding aims are also associated with asthma exacerbations. Lastly, Specific Aim 4 will attempt to

21 replicate our findings in a separate group of African American participants with and without asthma. In summary, asthma is a complex disease with potentially distinct genetic predictors by ancestry. Persisting inequities in asthma complications by race-ethnicity underscore the need for improved disease biomarkers and therapeutic targets. As a step in this direction, we proffer an integrative approach with greater statistical power to identify asthma- related genes and their regulatory elements.

Department of Public Health Sciences

Principal Investigator: Gwen Alexander, Ph.D. Encouraging Young Adults to Make Effective Nutrition Choices: MENU Gen Y Study (NIH R01HD067314)

The MENU Gen Y Study will focus on developing an age-targeted web-based intervention designed to increase daily intake of fruit and vegetables for young adults (age 21 – 30 “Gen Y”) using features that appeal to and factors relevant to this targeted age group.

Principal Investigator: Gwen Alexander, Ph.D. Breastfeeding Support and Weight Management for Black Women: A Dual Intervention (NIH R21HD085138)

Excessive pregnancy-related weight retention is an important determinant of obesity and is more common among African American women. At the same time, breastfeeding, which has been recommended as a strategy to decrease weight retention is lowest among African American women. This racial disparity in breastfeeding may partly explain the disparity in obesity, but even if the two are not causally related, a dual intervention designed to increase breastfeeding duration and decrease postpartum weight retention makes practical sense because both are associated with the same critical postpartum time window. For this study, we will incorporate a postpartum weight management component into an effective breastfeeding support program. This dual intervention will use a combination of in- person, telephone, and interactive web/mobile-based health counseling to provide education and support for breastfeeding difficulties and postpartum weight management. The intervention will be delivered by peer counselors who will be trained to provide support using motivational interviewing techniques with consultation by experts. Additionally, the web-based platform includes tools for tracking diet and physical activity, and is accessible using mobile technology. We have designed the dual intervention to provide encouragement, information, and problem- solving assistance at the appropriate pre or postpartum stage for both breastfeeding support and maternal weight management. The mixed delivery mode has proven effective in other settings and is important to build a trusting relationship while allowing frequent and flexible methods for communicating during this vulnerable time in a new mom's life. The overall goal of this developmental/exploratory R21 proposal is to gather pilot data to effectively refine the intervention so that it can be tested in a larger, longer study using a factorial design in a future R01 phase. We will recruit, in one large inner-city prenatal care clinic (Henry Ford Health System, Detroit, MI), pregnant African American women (32-36 weeks gestation) who are considering breastfeeding (n=80), randomize them to the intervention or to a usual care group, and follow all participants to 20 weeks postpartum. Our specific aims are to: 1) test feasibility; assess acceptability; and 3) estimate the effect size of the intervention at 20 weeks postpartum relative to the usual care group on (1) breastfeeding duration and (2) postpartum weight retention. This project is significant because the combined intervention is designed to work synergistically on two interrelated, highly prevalent problems that disproportionately disadvantage African American families.

Principal Investigator: Andrea Cassidy-Bushrow, Ph.D. Delivery Mode, Environment and the Gut Microbiome: Influence on Childhood Body Size (NIH R01HD082147)

Caesarean section (CS) delivery, which accounts for ~32% of all US births, has been associated with offspring obesity. Little is known about the mechanisms linking CS with obesity risk. The gut microbiome, which varies by mode of delivery, is also associated with childhood obesity. In our established racially and socioeconomically diverse birth cohort (WHEALS; Wayne County Health, 22 Environment, Allergy and Asthma Longitudinal Study), the early-life gut microbiome is associated with body mass index (BMI) category at age 2 years; CS is associated with both a distinct early-life gut microbiome and with increased BMI at age 2 years; and the presence of pets in the home, which increases microbial diversity, reduces the association between CS and BMI. Our data provide evidence for a mediating role of the gut microbiome in the CS-obesity relationship. However, to provide stronger evidence requires additional study. This project builds on extant data in WHEALS and on-going data collection in a subset of these children to examine the role of the gut microbiome in the CS-obesity association. Children will be invited for a research clinic visit for comprehensive body size assessment and blood draw at age 10-12 years. Gut microbiome composition and predicted function will be measured in banked early- life (1 and 6 months of infancy) stool samples and in samples from these children at age 10-12 years using the 16S rRNA and ITS2 biomarker genes and the Illumina MiSeq platform. A metabolomics analysis will be conducted in a subset of these stool samples. Adiposity will be measured as BMI at ages 2 and 10-12 years, BMI trajectory from birth to age 10-12 years, and anthropometric, bioimpedance and inflammatory measures at ages 10-12 years. Combined, we anticipate 630 unique children will have 10-year adiposity measures and at least one early-life microbiome measure (~405 with 1 month and ~381 with 6 month stool samples, which includes ~300 children with paired 1 and 6 month samples). Of these children, 400 will also have gut microbiome measured at age 10-12 years. Our specific aims are to: (1) examine if mode of delivery is associated with childhood adiposity; (2) examine if the gut microbiome is associated with childhood adiposity; and (3) examine whether the gut microbiome mediates relationships between mode of delivery and measures of adiposity. Such a complementary “omics” approach has never been applied to the study of childhood obesity and is likely to provide critical insights into disease development in early- life as well as potential targets amenable for intervention.

Overall Principal Investigator: Christine Cole-Johnson, Ph.D. Project 3, Project 4 Principal Investigator: GanesaWegienka, Ph.D. Project 1 Pets and the Infant Microbiome: Effect on Immune Maturation & Atopic Asthma (NIH P01A1089473)

This Program Project Grant (PPG) study seeks an increased understanding of the relationships between dog or cat exposure during infancy and a lower risk of allergic asthma. We believe that this protective association is related to different patterns of microbial stimulation during immune development. Four synergistic Projects will examine our hypothesis that the presence of pets in a home results in a more diverse bacterial community composition (BCC) of the dust in the home which in turn influences the development of the gut BCC of a newborn infant living in the home. A more diverse gut BCC shifts the maturation of the infant's immune system such that later immune responses are less likely to produce IgE antibody responses and allergic asthma. Project 1 examines the relationships between the presence of a dog or cat in a home, the BCC of dust in the home, the BCC of stools of infants living in homes and allergic sensitization at 2 years of age. An innovative, culture-independent microarray (G3 PhyloChip) will be used to characterize the BCCs utilizing previously collected samples from the ongoing WHEALS birth cohort study. Changes in home BCC following introduction of a dog are also examined. Project 2 will recruit a new birth cohort of children either living with or without a dog, measure infant stool BCC, and follow the cohort with detailed studies of immune function until 18 months of age to determine the impact of dog exposure on immune maturation. Project 3 uses mouse models of allergic asthma to further examine the influence of house dust from homes with and without dogs on immune responses that result in lung inflammation. The use of mouse models allows more detailed studies of immune functions from multiple compartments of the body than are possible with human children. Project 4 again utilizes the existing WHEALS birth cohort to examine the relationships between dog or cat exposure during the first year of age, 6-month infant stool BCC, and the presence of allergic asthma at 9 years of age. The Projects are supported by five Cores which each provide essential services to all four Projects. Subcontracts to the University of Michigan, UCSF, and Georgia Regents University, as well as the summaries of the Cores are not described here.

Principal Investigator: Christine Cole-Johnson, Ph.D. Project 3:

Allergic asthma is common in Westernized countries and its prevalence has increased greatly during

23 the last century. Interestingly recent research has shown that exposure to pets during infancy correlates with a lower risk of developing allergy and asthma in later life. In addition, data generated by the PPG investigators have demonstrated that pets can be associated with alterations to the microbiota in house dust. It is well known that soil and dust are ingested by children, and alterations in gut microbiome have been associated with risk for allergic asthma development. In order to further our understanding of the mechanisms that lead to the alterations observed clinically, this project has established and utilized models of pulmonary disease with exposure to dust from homes with dogs versus no pets. Using two different mouse models of allergic asthma (cockroach antigen and ovalbumin), we will study pulmonary immune responses after oral exposure to house dust using samples collected from homes with dogs and without pets. We will test the overall hypothesis that the composition of the dust microbiome from homes with dogs versus no pets differentially alters pulmonary immune responses during allergen exposure by changing the GI microbiota or bacterial community composition (BCC), resulting in systemic changes in antigen presenting cell and bone marrow progenitor cell programming and allergic outcomes. To test this hypothesis, we will specifically focus on clinically relevant mechanisms involved in the ability of pulmonary-derived allergen responses to induce Th2 cytokines, mucus hypersecretion, physiologic changes (AHR), and changes in innate responses locally as well as systemically. Our studies will: 1) establish that exposure of mice to dust from homes with dogs versus no pets will result in differential changes in the GI BCC, 2) demonstrate that the dog dust- altered gut microbiome alters pulmonary allergic responses, 3) establish that the dog dust- induced changes alter dendritic cell responses in the lung, 4) identify that changes in innate responses are a systemic effect by examining bone marrow cell responses, and 5) utilize innovative mouse models to derive the cellular mechanisms of the altered responses. BCC will be measured using the G3 PhyloChip. Thus, these studies, in close collaboration with the other projects in this PPG, will clarify a number of previously unexplored questions and will guide exploration into this novel area of research.

Project 4:

The overall objective of Project 4 is to assess the relationship between exposure to pets, the infant home and gut microbiomes, and allergic asthma at 9 years of age, using an ethnically diverse, population-based general risk birth cohort (the WHEALS cohort). A premise with growing evidence is that lack of exposure to particular patterns of microbial stimuli during early infancy results in a heightened T-helper (Th) 2 response in the maturing immune system, likely due to a suboptimal regulatory capacity, which in turn is associated in childhood with increased immunoglobulin (lg)E, allergy, and clinical allergic conditions such as asthma. Epidemiological studies have revealed that atopic conditions have increased over the latter half of the twentieth century. Humans, in earlier centuries had lifestyles associated with closer direct contact with soil, animals and other humans, suggesting exposure to environments with richer and more diverse microbiological burdens. We hypothesize that evolutionary adaptation to such microbial exposures with respect to immune recognition and regulation may result in untoward consequences when humans are presented with the different, and probably more limited, patterns of microbial exposures found in modern Westernized societies. Our theory is that in many settings, pets, as well as farm animals in close proximity, render the home microbiome, or bacterial community composition (BCC,) to be more similar to early 20th century environments with respect to an increased bacterial richness, diversity and a more even distribution of taxa. This home microbiome impacts directly through effects on the infant gastrointestinal tract BCC the immunogenesis of the infant and subsequently the development of clinically important outcomes such as childhood atopic asthma. Using a new technology (the G3 PhyloChip), capable of cost-effectively identifying, to a great depth, bacteria in environmental and biological samples, our collaborative team has preliminary data suggesting that the presence of dogs and cats is associated with distinct home and infant gut microbiomes characterized by dramatic increases in bacterial diversity, richness and evenness. Using newly measured outcome variables measured by questionnaire and clinical examinations in the WHEALS cohort, in conjunction with PhyloChip analyses of stored infant stool and dust samples, we will test whether distinct patterns of pet exposure, home microbiome and infant gut microbiome are associated with current allergic asthma at age 9 years.

Principal Investigator: Ganesa Wegienka, Ph.D. Project 1

24 The overarching hypothesis of Project 1 is that pet ownership is associated with exposure to a wider diversity of bacteria in house dust, and that these exposures profoundly influence the bacterial community composition (BCC) of the infant gastrointestinal microbiome, maturation of immune responsiveness and subsequently, the development of allergy and allergic asthma. This Project thus proposes two population-based studies and a longitudinal panel study to shed light upon mechanisms that may explain the observed protective effects of exposure to household pets during infancy against development of atopy and high total IgE in infancy. We propose to use an advanced, highly sensitiveand semi-quantitative method for bacterial detection, the G3 PhyloChip. This method offers an unprecedented capacity for detailed, high-resolution profiling of complex microbial communities, detecting in parallel common and uncommon members of assemblages present in house dust and infant stool samples. For Aims 1 and 2, we propose to examine samples already collected and stored form a large, carefully characterized, racially and socio-economically diverse, cohort of children (the WHEALS cohort). In Aim 1 we propose using an innovative case-cohort design to compare samples from infants who became atopic at age 2 years versus samples form a randomly selected sub-cohort (serving as the control group). Using the sub-cohort in Aim 2, we will determine whether, and in what fashion, bacterial community composition of both house dust and infant stool are impacted by pet-keeping and if they are related to each other. The study of bacteria, or bacterial communities, identified as deriving from dog keeping will be enabled by a small prospective panel study proposed as Aim 3, to analyze the changes in microbial community composition of house dust in child-occupied but previously pet-free households into which a dog is introduced. Because the 16S-rRNAPhyloChipprovides information on relative abundance of every bacterial taxon detected, we aim, through statistical analyses, to take advantage of this semi- quantitative data to identify particular bacterial species as critically important in protection against atopy development.

Principal Investigator: Christine Cole-Johnson, Ph.D. Personalizing Care for Obese Patients in an Urban Health System (Agency for Healthcare Research and Quality R24HS022417)

Today, patients and providers are presented with more health care options than ever before. There is considerable doubt and lack of understanding of science not only among patients, but also among physicians. Without systematic, evidence-based guidance for the appropriate and efficient use of the multitude of treatment options, as well as the consideration of patient preferences, the rapid growth and complexity of treatments will only add to the existing confusion about which option is best for each individual patient. The objective of the proposed Patient-Centered Outcome Research Center (PCORC) is to fully leverage and further develop the research infrastructure and clinical assets of Henry Ford Health System (HFHS) in order to conduct Patient-Centered Outcomes Research (PCOR). The PCOR evidence will guide care in order to achieve patient-desired outcomes in our urban and suburban patient populations located throughout Metropolitan Detroit. The Center will be organized into four different Cores (Patient Engagement Core, Study Design and Analysis/Measurement Core, Patient Data Network Core, and Implementation/Dissemination Core) with different functions. The Center currently has three PCOR projects proposed that are focused on our selected theme of caring for the obese patient. The HFHS PCORC will maximize programmatic and scientific efficiency within our health care system setting, promote shared use of resources and standardization of processes and procedures, promote training in PCOR/Comparative Effectiveness Research (CER) methods, and facilitate rapid dissemination of research findings to the medical community and translation of those results into our system's clinical practice.

The Center will build on existing research capabilities by developing expertise in novel PCOR methods through didactic course work, educational sessions at national meetings and content- specific educational seminars. These educational experiences will allow the Center staff to learn how to develop and conduct innovative PCOR.studies that will provide evidence for the many pressing issues in patient care. The Center will demonstrate its proficiency through the conduct of the proposed projects.

The proposed PCORC is relevant to public health because it provide research infrastructure and methods for the design and conduct of patient-centered outcome research (PCOR) projects in patients within our health care system. The results of those projects will provide evidence-based

25 and patient-centered guidelines available to physicians in their offices, on a real-lime basis in order to ultimately provide care that places each individual patient and his/her preferences at the center of decision-making.

Principal Investigator: Christine Cole-Johnson, Ph.D. Trans-America Consortium of the Health Care Systems Research Network for the Precision Medicine Initiative Cohort Program (NIH 1OT2OD024610) Aim 1: Using our existing network of Patient Advisors and experts, finalize the TACH governance and establish an oversight structure to a) continuously conduct rapid assessments of recruitment, enrollment and retention goals, and b) rapidly deploy and test interventions and apply modifications as necessary, for the following processes: 1. Engagement of all recruitment site facilities and staff in our initial designated catchment areas; 2. Outreach and enrollment of research-empowered Patient Partners; 3. Collection and transfer of Patient Partners’ consent, survey and physical exam data, and biospecimens; 4. Periodic compilation and transfer of Patient Partners’ EHR data to the PMI-CP Coordinating Center and return of data to Patient Partners. Aim 2: Fully enroll within a 12 month period 10,000 Patient Partners (defined as completion of informed consent, baseline exam and survey, biospecimen collection, and initial and recurring extraction of their EHR data). Submit specimens daily to the PMI-CP Biobank and EHR data as one pipeline to the PMI-CP Data and Research Support Center (DRSC) on the schedule determined by the PMI-CP Steering Committee (PMI-CP SC). Return individual and comparative data to Patient Partners as specified.

Principal Investigator: Christine Cole-Johnson, Ph.D. Children’s Respiratory and Environmental Workgroup (CREW) (NIH UG3OD023282)

The grant is part of $157 million in awards announced yesterday by the NIH that launches a seven-year initiative called Environmental Influences on Child Health Outcomes (ECHO). The ECHO program will investigate how exposure to a range of environmental factors in early development – from conception through early childhood – influences the health of children and adolescents.

Study Highlights The CREW consortium will be tasked with identifying specific asthma subtypes and overcome shortcomings of individual cohorts by: Providing a large and diverse national data set of nearly 9,000 births and long-term follow-up for 6,000-7,000 children and young adults. Harmonizing data related to asthma clinical indicators and early-life environmental exposures. Developing standardized measures for prospective data collection across CREW cohorts and other ECHO studies. Conducting targeted enrollment of additional subjects into existing cohorts.

Experiences during sensitive developmental windows, including around the time of conception, later in pregnancy, and during infancy and early childhood, can have long-lasting effects on the health of children. These experiences encompass a broad range of exposures, from air pollution and chemicals in our neighborhoods, to societal factors such as stress, to individual behaviors like sleep and diet. They may act through any number of biological processes, for example changes in the expression of genes or development of the immune system.

Principal Investigator: Albert Levin, Ph.D. Comprehensive Analysis of Gene-Environment Interaction in Sarcoidosis (NIH R21HL129023)

Sarcoidosis is a multi-organ granulomatous, inflammatory disease of uncertain etiology, with 90% of cases presenting pulmonary involvement. Despite convincing evidence that sarcoidosis likely arises when a genetically-susceptible host is exposed to a causative environmental agent, studies of environmental agents and disease risk suggest that there is more than one single environmental trigger. Further, there have been few gene-environment interaction (GxE) studies of disease etiology published to date; those few have focused on the class II genes within the Human Leukocyte Antigen (HLA) region, the most studied and validated region associated with sarcoidosis risk. In the United States, African Americans are

26 at highest risk for sarcoidosis; the adjusted annual incidence among African Americans is roughly three times that of European Americans (35.5/100,000 versus 10.9/100,000). Among African Americans, the disease is also more likely to be chronic and severe. We recently performed the first gene-environment-wide interaction study (GEWIS) of insecticide exposure and sarcoidosis risk in the Ancestry Mapping of Sarcoidosis Study (AMASS), a large study of sarcoidosis in African Americans. Using our recently-developed methodology, we identified a genome-wide significant GxE association in the FUT9 gene. To build on this effort, the current proposal will focus on the family-based portion of AMASS (503 families, including 818 sarcoidosis cases and 632 healthy family members), which has a rich resource of both environmental exposure and genetic (genome-wide genotyping, targeted/full exome sequencing, and imputed HLA Class I and II genes) data available. First, we propose to identify environmental exposures associated with sarcoidosis risk (Aim 1). Where existing sarcoidosis studies have been limited to investigating environmental exposures in isolation, we will move beyond this trend by using latent-class analysis (LCA) to identify patterns across multiple environmental exposures. Associated environmental exposures (individual and/or LCA-identified multi-exposure groups) will be evaluated for GxE effects (Aim 2). Current family-based GEWIS have focused on the exhaustive strategy of testing all genetic variants. To attempt to improve power, we will extend a two-step strategy to our study of related and admixed individuals and compare both exhaustive and two-step GEWIS strategies via simulation. The strategy with the highest power that also controls the type-1 error rate will be selected for GxE testing for the environmental factors from Aim 1. In summary, we propose multiple innovations to the fields of both GxE analysis and sarcoidosis research that increase the chance for better understanding of the etiology of this debilitating disease.

Principal Investigator: Benjamin Rybicki, Ph.D. A Nested Case-Control Study of ProstateCarcinogenesis (NIH R01ES011126)

Chronic inflammation, which is caused by infectious agents or exposure to environmental factors such as heterocyclic amines, is believed to play a role in up 20% of adult cancers. In prostate, genetic, molecular pathology, and toxicology data suggest that inflammation- related processes are involved in cancer development, but these data conflict with results of epidemiological studies that show an inverse correlation between inflammation and prostate cancer risk. This may be due to bias in the factors that lead men to undergo prostate biopsy, as well as complexity of the inflammatory phenotype itself. Our proposed study will address this paradox by dissecting inflammation at the cellular, molecular, and clinical level. The Henry Ford Health System biorepository contains benign prostate tissue specimens collected from over 9,000 men over the past 20 years, including over 1,000 men who subsequently developed prostate cancer. Using this unique cohort with its annotated clinical baseline and follow-up data, we will conduct a nested case- control study of 700 prostate cancer case- control pairs. Characterizing inflammatory markers in these pre-disease specimens will allow us to determine the nature of tumor- suppressive vs. tumor- supportive inflammatory signatures. We will also measure telomere length in the same benign prostate tissue specimens in which we characterize inflammation to assign a malignancy-potential signature to each specimen. Approximately 1 million prostate biopsies are performed annually in the US, twothirds of which reveal benign condition. Our cohort includes a large group of patients who are at high risk of prostate cancer despite a negative biopsy. An in-depth characterization of inflammation in the benign prostate, before histologic signs of malignancy become apparent, will provide insight into the type of inflammatory milieu associated with eventual tumor development as well as cancer progression and recurrence. A better understanding of the clinical implications of chronic inflammation of the prostate so often observed in older men can have significant impact upon millions of men where currently a negative biopsy offers little reassurance in terms of prostate cancer outcomes.

Principal Investigator: Ganesa Wegienka, Ph.D. Epidemiology of Allergic Disease Endotypes (NIH R01AI110450)

Pediatric allergy and asthma are a costly public health burden, but so far substantial research efforts have yielded no prevention strategies. A likely reason is that despite longstanding recognition by the medical community that the term ‘asthma’ refers to a collection of diseases, researchers have historically treated the syndrome as a single disease entity. Epidemiologically, the collapse of 27 different phenotypes (observed disease patterns) and endotypes (phenotypes further delineated by pathophysiological processes), into a single category corrupts associations between risk factors and diseases. Thus, progress in allergic disease research has been hampered. Prior attempts have been made to identify such phenotypes and endotypes, but a combination of incomplete data and oversimplified statistical methods have limited progress.We propose to apply sophisticated latent class analyses in a large general risk cohort combined with immunological markers to finely discriminate asthma and allergy disease phenotypes and endotypes and then use this information to conduct risk factor analyses. Using this approach in our WHEALS birth cohort, we have already characterized four classes at age 2 years: 1) Low to No Sensitization; 2) Highly Sensitized; 3) Milk and Egg Dominated Sensitization; and 4) Peanut and/or Inhalant allergen – No Milk Sensitization. Total IgE levels varied between the groups, as did the rates of eczema and doctor diagnosis of asthma (at age 4 years). The Highly Sensitized had the greatest rates, the Low to No Sensitization had the lowest rates, and the other two classes had rates intermediate between the Low and High Sensitization groups. These data suggest the use of latent classes, rather than the use of the “traditional” definition of atopy (any allergen-specific IgE (sIgE) _0.35 IU/mL), more specifically identifies those on a trajectory for allergic disease, yielding advancement in both allergic disease research and clinical care. Using the predominantly (62%) African American birth cohort WHEALS, we will: Aim 1) Determine which early life allergic disease phenotypes identified at age 2 years are associated with lung function (spirometry and methacholine challenge) at age 10 years; Aim 2) a) Identify the allergic disease endotypes for 10 year old children based on annual report of wheeze; lung function, eNO, obesity, cytokines, and white cell counts and extensive immunophenotyping [assessment of cellular markers to identify and quantify activation of regulatory T cells (Tregs), basophils and dendritic cells (DCs)] at age 10 years; and total IgE and sensitization (sIgE and skin prick tests) at ages 2 and 10 years; and, b) Estimate associations between early life risk factors (e.g., delivery type, pet exposure, etc.) and the identified Aim 2a endotypes; and, 3) Compare and contrast the risk factor associations with the endotypes in Aim 2 to the risk factor associations determined using “traditional” definitions of atopy and asthma (doctor diagnosis and medication use and/or symptoms in the last year). Analyses will be performed for all 900 WHEALS cohort children and separately for Black children and White children to assess racial differences.

28 Henry Ford Health System 2016 Publication List

ANESTHESIOLOGY

Kim DD, Asif A, and Kataria S. Presentation of neurolytic effect of 10% lidocaine after perineural ultrasound guided injection of a canine sciatic nerve: A pilot study Korean J Pain 2016; 29(3):158-163. PMID: 27413480. Full Text

Kim DD, and Sibai N. Prolongation of greater occipital neural blockade with 10% lidocaine neurolysis: a case series of a new technique J Pain Res 2016; 9:721-725. PMID: 27729811. Full Text

Konda P, Ai D, Guerra CE, Rodriguez-Restrepo A, Mehran RJ, Rice D, Hofstetter W, Heir J, Kwater P, Gottumukkala V, Hernandez M, and Cata JP. Identification of risk factors associated with postoperative acute kidney injury after esophagectomy for esophageal cancer J Cardiothorac Vasc Anesth 2016;PMID: 27720491. Full Text

Loomba V, Kaveeshvar H, Upadhyay A, and Sibai N. Neuropathic pain in cancer patients: A brief review Indian J Cancer 2015; 52(3):425-428. PMID: 26905158. Full Text

Loomba V, Kaveeshvar H, and Dwivedi S. Paraplegia after thoracic epidural steroid injection A A Case Rep 2016;PMID: 27536909. Article Request Form

Loomba V, Upadhyay A, and Kaveeshvar H. Radiofrequency ablation of the sphenopalatine ganglion using cone beam computed tomography for intractable cluster headache Pain Physician 2016; 19(7):E1093-1096. PMID: 27676681. Full Text

Patel S, Weierstahl KL, Shah S, and Fidkowski CW. Anesthetic management for cesarean delivery in a patient with pulmonary emboli, pulmonary hypertension, and right ventricular failure A A Case Rep 2016;PMID: 27513968. Article Request Form

29 BEHAVIORAL HEALTH SERVICES/PSYCHIATRY

Ahmedani BK, Belville-Robertson T, Hirsch A, and Jurayj A. An online mental health and wellness intervention supplementing standard care of depression and anxiety Arch Psychiatr Nurs 2016; 30(6):666-670. PMID: 27888957. Full Text

Ahmedani BK, Peterson EL, Wells KE, Henein F, and Williams LK. Long-term management of low back pain with opioids and non-steroidal anti-inflammatory drugs in a health system Am J Prev Med 2016;PMID: 26970664. Full Text

Baker-Genaw K, Kokas MS, Ahsan SF, Darnley-Fisch D, Drake S, Goyal N, Inamdar K, Moutzouros V, Prabhakar D, Rolland L, Sangha R, Shreve M, and Woodward A. Mapping direct observations from objective structured clinical examinations to the milestones across specialties J Grad Med Educ 2016; 8(3):429-434. PMID: 27413450. Full Text

Fritzler L, and Prabhakar D. Green's child and adolescent clinical psychopharmacology, 5th edition J Am Acad Child Adolesc Psychiatry 2016; 55(7):633-634. PMID: Not assigned. Full Text

Henein F, Prabhakar D, Peterson EL, Williams LK, and Ahmedani BK. A prospective study of antidepressant adherence and suicidal ideation among adults Prim Care Companion CNS Disord 2016; 18(6)PMID: 27907275. Article Request Form

Jesse MT, Rubinstein E, Eshelman A, Wee C, Tankasala M, Li J, and Abouljoud M. Lifestyle and self- management by those who live it: Patients engaging patients in a chronic disease model Perm J 2016; 20(3)PMID: 27455056. Article Request Form

Ketterer MW, Alaali Y, Yessayan L, and Jennings J. "Alert and oriented x 3?" Correlates of mini-cog performance in a post/nondelirious intensive care unit sample Psychosomatics 2015;PMID: 26805587. Full Text

Kroll HR, Macaulay T, and Jesse M. A preliminary survey examining predictors of burnout in pain medicine physicians in the united states Pain Physician 2016; 19(5):E689-696. PMID: 27389112. Full Text

Miller-Matero LR, Dykhuis KE, Albujoq K, Martens K, Fuller BS, Robinson V, and Willens DE. Benefits of integrated behavioral health services: The physician perspective Fam Syst Health 2016; 34(1):51-55. PMID: 26963777 Full Text

Miller-Matero LR, Bryce K, Hyde-Nolan ME, Dykhuis KE, Eshelman A, and Abouljoud M. Health literacy status affects outcomes for patients referred for transplant Psychosomatics 2016;PMID: 27231187. Full Text

Miller-Matero LR, Chipungu K, Martinez S, Eshelman A, and Eisenstein D. How do I cope with pain? Let me count the ways: awareness of pain coping behaviors and relationships with depression and anxiety Psychol Health Med 2016:1-9. PMID: 27221277. Article Request Form

Park G, and Prabhakar D. Inviting police officers to grand rounds Acad Psychiatry 2016; 40(1):194-195. PMID: 26691142. Full Text

Paulson D, Shah M, Miller-Matero LR, Eshelman A, and Abouljoud M. Cognition predicts quality of life among patients with end-stage liver disease Psychosomatics 2016;PMID: 27184728. Full Text

Pheister M, Stagno S, Cotes R, Prabhakar D, Mahr F, Crowell A, and Schwartz A. Simulated patients and scenarios to assess and teach psychiatry residents Acad Psychiatry 2016;PMID: 26763534. Full Text

Singh G, and Prabhakar D. Neuropsychiatric presentation of anti-n-methyl-d-aspartate receptor encephalitis with comorbid sinus venous thrombosis Prim Care Companion CNS Disord 2016; 18(6)PMID: 27922228. Full text

30 Behavioral Health Services/Neuropsychology

Goldenberg PC, Adler BJ, Parrott A, Anixt J, Mason K, Phillips J, Cooper DS, Ware SM, and Marino BS. High burden of genetic conditions diagnosed in a cardiac neurodevelopmental clinic Cardiol Young 2016:1-8. PMID: 27641144. Article Request Form

Meinzen-Derr J, Wiley S, Phillips J, Altaye M, and Choo DI. The utility of early developmental assessments on understanding later nonverbal IQ in children who are deaf or hard of hearing Int J Pediatr Otorhinolaryngol 2017; 92:136-142. PMID: 28012515. Full text

Sidiropoulos C, Rammo R, Merker B, Mahajan A, LeWitt P, Kaminski P, Womble M, Zec A, Taylor D, Wall J, and Schwalb JM. Intraoperative MRI for deep brain stimulation lead placement in Parkinson's disease: 1 year motor and neuropsychological outcomes J Neurol 2016; 263(6):1226- 1231. PMID: 27126457. Full Text

31 CENTER FOR HEALTH POLICY AND HEALTH SERVICES RESEARCH

Abid Z, Oh SS, Hu D, Sen S, Huntsman S, Eng C, Farber HJ, Rodriguez-Cintron W, Rodriguez- Santana JR, Serebrisky D, Avila PC, Thyne SM, Kim KA, Borrell LN, Keoki Williams L, Seibold MA, Burchard EG, and Kumar R. Maternal age and asthma in Latino populations Clin Exp Allergy 2016;PMID: 27238356. Full Text

Ahmedani BK, Peterson EL, Wells KE, Henein F, and Williams LK. Long-term management of low back pain with opioids and non-steroidal anti-inflammatory drugs in a health system Am J Prev Med 2016;PMID: 26970664. Full Text

Ahmedani BK, Belville-Robertson T, Hirsch A, and Jurayj A. An online mental health and wellness intervention supplementing standard care of depression and anxiety Arch Psychiatr Nurs 2016; 30(6):666-670. PMID: 27888957. Full Text

Ali R, Schwalb JM, Nerenz DR, Antoine HJ, and Rubinfeld I. Use of the modified frailty index to predict 30-day morbidity and mortality from spine surgery J Neurosurg Spine 2016:1-5. PMID: 27153143. Full Text

Brady JE, Liffmann DK, Yartel A, Kil N, Federman AD, Kannry J, Jordan C, Massoud OI, Nerenz DR, Brown KA, Smith BD, Vellozzi C, and Rein DB. Uptake of hepatitis c screening, characteristics of patients tested, and intervention costs in the BEST-C study Hepatology 2016;PMID: 27770543. Full Text

Buu A, Williams LK, and Yang JJ. An efficient genome-wide association test for mixed binary and continuous phenotypes with applications to substance abuse research Stat Methods Med Res 2016;PMID: 27215414. Full Text

Cajigal S, Wells KE, Peterson EL, Ahmedani BK, Yang JJ, Kumar R, Burchard EG, and Williams LK. Predictive properties of the asthma control test and its component questions for severe asthma exacerbations J Allergy Clin Immunol Pract 2016;PMID: 27544712. Full Text

Coffey MJ, and Ahmedani BK. Pseudocide: A case report J Psychiatr Pract 2016; 22(4):333-335. PMID: 27427845. Full Text

Coleman KJ, Stewart C, Waitzfelder BE, Zeber JE, Morales LS, Ahmed AT, Ahmedani BK, Beck A, Copeland LA, Cummings JR, Hunkeler EM, Lindberg NM, Lynch F, Lu CY, Owen-Smith AA, Trinacty CM, Whitebird RR, and Simon GE. Racial-ethnic differences in psychiatric diagnoses and treatment across 11 health care systems in the mental health research network Psychiatr Serv 2016:appips201500217. PMID: 27079987. Full Text

El-Refai M, Hrobowski T, Peterson EL, Wells K, Spertus JA, Williams LK, and Lanfear DE. Race and association of angiotensin converting enzyme/angiotensin receptor blocker exposure with outcome in heart failure J Cardiovasc Med (Hagerstown) 2015; 16(9):591-596. PMID: 24842464. Full Text

Fishbein AB, Lee TA, Cai M, Oh SS, Eng C, Hu D, Huntsman S, Farber HJ, Serebrisky D, Silverberg J, Williams LK, Seibold MA, Sen S, Borrell LN, Avila P, Rodriguez-Cintron W, Rodriguez-Santana JR, Burchard EG, and Kumar R. Sensitization to mouse and cockroach allergens and asthma morbidity in urban minority youth: Genes-environments and admixture in latino american (gala-ii) and study of african-americans, asthma, genes, and environments (SAGE- II) Ann Allergy Asthma Immunol 2016;PMID: 27238578. Full Text

Henein F, Prabhakar D, Peterson EL, Williams LK, and Ahmedani BK. A prospective study of antidepressant adherence and suicidal ideation among adults Prim Care Companion CNS Disord 2016; 18(6)PMID: 27907275. Article Request Form

Hu J, and Nerenz D. Relationship between stress rankings and the overall hospital star ratings: An analysis of 150 cities in the united states JAMA Intern Med 2016;PMID: 27893893. Full Text

32 Jaffee KD, Shires DA, and Stroumsa D. Discrimination and delayed health care among transgender women and men: Implications for improving medical education and health care delivery Med Care 2016;PMID: 27314263. Full Text

Kabbani LS, Wasilenko S, Nypaver TJ, Weaver MR, Taylor AR, Abdul-Nour K, Borgi J, and Shepard AD. Socioeconomic disparities affect survival after aortic dissection J Vasc Surg 2016; 64(5):1239-1245. PMID: 27374067. Full Text

Karvelas DA, Rundell SD, Friedly JL, Gellhorn AC, Gold LS, Comstock BA, Heagerty PJ, Bresnahan BW, Nerenz DR, and Jarvik JG. Subsequent healthcare utilization associated with early physical therapy for new episodes of low back pain in older adults Spine J 2016;PMID: 27765707. Full Text

Kessler MD, Yerges-Armstrong L, Taub MA, Shetty AC, Maloney K, Jeng LJ, Ruczinski I, Levin AM, Williams LK, Beaty TH, Mathias RA, Barnes KC, and O'Connor TD. Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry Nat Commun 2016; 7:12521. PMID: 27725664. Full Text

Luzum JA, and Lanfear DE. Pharmacogenetic risk scores for perindopril clinical and cost effectiveness in stable coronary artery disease: When are we ready to implement? J Am Heart Assoc 2016; 5(3):e003440. PMID: 27021567. Full Text

Mathias RA, Taub MA, Gignoux CR, Fu W, Musharoff S, O'Connor TD, Vergara C, Torgerson DG, Pino- Yanes M, Shringarpure SS, Huang L, Rafaels N, Boorgula MP, Johnston HR, Ortega VE, Levin AM, Song W, Torres R, Padhukasahasram B, Eng C, Mejia-Mejia DA, Ferguson T, Qin ZS, Scott AF, Yazdanbakhsh M, Wilson JG, Marrugo J, Lange LA, Kumar R, Avila PC, Williams LK, Watson H, Ware LB, Olopade C, Olopade O, Oliveira R, Ober C, Nicolae DL, Meyers D, Mayorga A, Knight-Madden J, Hartert T, Hansel NN, Foreman MG, Ford JG, Faruque MU, Dunston GM, Caraballo L, Burchard EG, Bleecker E, Araujo MI, Herrera-Paz EF, Gietzen K, Grus WE, Bamshad M, Bustamante CD, Kenny EE, Hernandez RD, Beaty TH, Ruczinski I, Akey J, and Barnes KC. A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome Nat Commun 2016; 7:12522. PMID: 27725671. Full Text

Mitchell S, Roso S, Samuel M, and Pladevall-Vila M. Unmet need in the hyperlipidaemia population with high risk of cardiovascular disease: a targeted literature review of observational studies BMC Cardiovasc Disord 2016; 16(1):74. PMID: 27114245. Full Text

Neophytou AM, White MJ, Oh SS, Thakur N, Galanter JM, Nishimura KK, Pino-Yanes M, Torgerson DG, Gignoux CR, Eng C, Nguyen EA, Hu D, Mak AC, Kumar R, Seibold MA, Davis A, Farber HJ, Meade K, Avila PC, Serebrisky D, Lenoir MA, Brigino-Buenaventura E, Rodriguez-Cintron W, Bibbins- Domingo K, Thyne SM, Williams LK, Sen S, Gilliland FD, Gauderman WJ, Rodriguez-Santana JR, Lurmann F, Balmes JR, Eisen EA, and Burchard EG. Air pollution and lung function in minority youth with asthma in the GALA II & SAGE II Studies Am J Respir Crit Care Med 2016;PMID: 26734713. Full Text

Nerenz DR. Challenges in moving to "pay for outcomes" J Ambul Care Manage 2016; 39(2):122-124. PMID: 26945294. Full Text

Oh S, Du R, Zeiger AM, McGarry ME, Hu D, Thakur N, Pino-Yanes M, Galanter JM, Farber HJ, Eng C, Nishimura KK, Huntsman S, Meade K, Avila P, Serebrisky D, Bibbins-Domingo K, Lenoir MA, Ford JG, Brigino-Buenaventura E, Rodriguez-Cintron W, Thyne SM, Sen S, Rodriguez-Santana JR, Williams K, Kumar R, and Burchard EG. Breastfeeding associated with higher lung function in African American youths with asthma J Asthma 2016:0. PMID: 27929698. Full text

Owen-Smith A, Stewart C, Green C, Ahmedani BK, Waitzfelder BE, Rossom R, Copeland LA, and Simon GE. Adherence to common cardiovascular medications in patients with schizophrenia vs. patients without psychiatric illness Gen Hosp Psychiatry 2016; 38:9-14. PMID: 26423559. Full Text

33 Pladevall M, Riera-Guardia N, Margulis AV, Varas-Lorenzo C, Calingaert B, and Perez-Gutthann S. Cardiovascular risk associated with the use of glitazones, metformin and sufonylureas: meta-analysis of published observational studies BMC Cardiovasc Disord 2016; 16(1):14. PMID: 26769243. Full Text

Rossom RC, Shortreed S, Coleman KJ, Beck A, Waitzfelder BE, Stewart C, Ahmedani BK, Zeber JE, and Simon GE. Antidepressant adherence across diverse populations and healthcare settings Depress Anxiety 2016;PMID: 27320786. Full Text

Rossom RC, Simon GE, Beck A, Ahmedani BK, Steinfeld B, Trangle M, and Solberg L. Facilitating action for suicide prevention by learning health care systems Psychiatr Serv 2016; 67(8):830-832. PMID: 27032667. Full Text

Rundell SD, Goode AP, Suri P, Heagerty PJ, Comstock BA, Friedly JL, Gold LS, Bauer Z, Avins AL, Nedeljkovic SS, Nerenz DR, Kessler L, and Jarvik JG. The impact of comorbid knee and hip osteoarthritis on longitudinal clinical and health care use outcomes in older adults with new visits for back pain Arch Phys Med Rehabil 2016;PMID: 27519927. Full Text

Rundell SD, Sherman KJ, Heagerty PJ, Mock CN, Dettori NJ, Comstock BA, Avins AL, Nedeljkovic SS, Nerenz DR, and Jarvik JG. Predictors of persistent disability and back pain in older adults with a new episode of care for back pain Pain Med 2016;PMID: 27688311. Article Request Form

Scherrer JF, Salas J, Copeland LA, Stock EM, Ahmedani BK, Sullivan MD, Burroughs T, Schneider FD, Bucholz KK, and Lustman PJ. Prescription opioid duration, dose, and increased risk of depression in 3 large patient populations Ann Fam Med 2016; 14(1):54-62. PMID: 26755784. Full Text

Scherrer JF, Salas J, Sullivan MD, Schneider FD, Bucholz KK, Burroughs T, Copeland L, Ahmedani B, and Lustman PJ. The influence of prescription opioid use duration and dose on development of treatment resistant depression Prev Med 2016;PMID: 27497660. Full Text

Scherrer JF, Salas J, Schneider FD, Bucholz KK, Sullivan MD, Copeland LA, Ahmedani BK, Burroughs T, and Lustman PJ. Characteristics of new depression diagnoses in patients with and without prior chronic opioid use J Affect Disord 2016; 210:125-129. PMID: 28033519. Full text

Wells KE, Cajigal S, Peterson EL, Ahmedani BK, Kumar R, Lanfear DE, Burchard EG, and Williams LK. Assessing differences in inhaled corticosteroid response by self-reported race-ethnicity and genetic ancestry among asthmatic subjects J Allergy Clin Immunol 2016;PMID: 27016472. Full Text

Willame C, Rosillon D, Zima J, Angelo MG, Stuurman AL, Vroling H, Boggon R, Bunge EM, Pladevall-Vila M, and Baril L. Risk of new onset autoimmune disease in 9- to 25-year-old women exposed to human papillomavirus-16/18 AS04-adjuvanted vaccine in the United Kingdom Hum Vaccin Immunother 2016:0. PMID: 27428517. Article Request Form

Yang JJ, Li J, Williams LK, and Buu A. An efficient genome-wide association test for multivariate phenotypes based on the Fisher combination function BMC Bioinformatics 2016; 17(1):19. PMID: 26729364. Full Text

Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorsky M, Zidzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkac I, Kooy A, van Schaik RH, Stehouwer CD, Logie L, Sutherland C, Klovins J, Pirags V, Hofman A, Stricker BH, Motsinger-Reif AA, Wagner MJ, Innocenti F, Hart LM, Holman RR, McCarthy MI, Hedderson MM, Palmer CN, Florez JC, Giacomini KM, and Pearson ER. Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin Nat Genet 2016;PMID: 27500523. Full Text

34 Center for Health Promotion and Disease Prevention

Holm AL, Rowe Gorosh M, Brady M, and White-Perkins D. Recognizing privilege and bias: An interactive exercise to expand health care providers' personal awareness Acad Med 2016;PMID: 27355785. Full Text

35 DERMATOLOGY

Agbai O, Hamzavi I, and Jagdeo J. Laser treatments for postinflammatory hyperpigmentation: A systematic review JAMA Dermatol 2016;PMID: 27973642. Full text

Agrawal S, Porto DA, and Lim HW. Paradoxically dark spontaneous repigmentation: a rare complication of generalized vitiligo J Eur Acad Dermatol Venereol 2016;PMID: 27785821. Full Text

Ahn JW, Johnson K, Kohen LL, Chaffins ML, and Shwayder T. Melanoma gene expression markers for surveillance of epidermolysis bullosa nevi malignant transformation JAMA Dermatol 2016;PMID: 26865206. Full Text

Almario L, Antonyan AS, Porto DA, Gomez-Roberts H, Alhousseini A, and Gonik B. Management of psoriasis herpeticum in pregnancy: A clinical conundrum Case Rep Obstet Gynecol 2016; 2016:5319425. PMID: 27840756. Full Text

Boer B, Tisack A, and Shwayder T. Transient porphyrinemia in a neonate: A case report Pediatr Dermatol 2016;PMID: 27573700. Full Text

Chen WB, Gao L, Wang J, Wang YG, Dong Z, Zhao J, Mi QS, and Zhou L. Conditional ablation of HDAC3 in islet beta cells results in glucose intolerance and enhanced susceptibility to STZ-induced diabetes Oncotarget 2016;PMID: 27542279. Full Text

Dzinic SH, Bernardo MM, Li X, Fernandez-Valdivia R, Ho YS, Mi QS, Bandyopadhyay S, Lonardo F, Vranic S, Oliveira D, Bonfil RD, Dyson G, Chen K, Omerovic A, Sheng X, Han X, Wu D, Bi X, Cabaravdic D, Jakupovic U, Wahba M, Pang A, Harajli D, Sakr W, and Sheng S. An essential role of maspin in embryogenesis and tumor suppression Cancer Res 2016;PMID: 27923833. Full text

Friedman BJ, Mehta D, and Chaffins ML. Friable nodules on the elbow of a transplant patient JAMA Dermatol 2016;PMID: 26886712. Full Text

Gan EY, Eleftheriadou V, Esmat S, Hamzavi I, Passeron T, Bohm M, Anbar T, Goh BK, Lan CE, Lui H, Ramam M, Raboobee N, Katayama I, Suzuki T, Parsad D, Seth V, Lim HW, van Geel N, Mulekar S, Harris J, Wittal R, Benzekri L, Gauthier Y, Kumarasinghe P, Thng ST, Silva de Castro CC, Abdallah M, Vrijman C, Bekkenk M, Seneschal J, Pandya AG, Ezzedine K, Picardo M, and Taieb A. Repigmentation in vitiligo: Position paper of the vitiligo global issues consensus conference (VGICC) Pigment Cell Melanoma Res 2016;PMID: 27864868. Full Text

Garzon MC, Epstein LG, Heyer GL, Frommelt PC, Orbach DB, Baylis AL, Blei F, Burrows PE, Chamlin SL, Chun RH, Hess CP, Joachim S, Johnson K, Kim W, Liang MG, Maheshwari M, McCoy GN, Metry DW, Monrad PA, Pope E, Powell J, Shwayder TA, Siegel DH, Tollefson MM, Vadivelu S, Lew SM, Frieden IJ, and Drolet BA. PHACE syndrome: Consensus-derived diagnosis and care recommendations J Pediatr 2016; 178:24-33.e22. PMID: 27659028. Full Text

Gaulding JV, Yang S, and Lim HW. An african american man with diffuse erythematous papules JAMA Dermatol 2016;PMID: 27760240. Full Text

Giordano CN, Yew YW, Spivak G, and Lim HW. Understanding photodermatoses associated with defective DNA repair: Syndromes with cancer predisposition J Am Acad Dermatol 2016; 75(5):855- 870. PMID: 27745641. Full Text

Gordon SL, Porto DA, Ozog DM, and Council ML. Creating and editing video to accompany manuscripts Dermatol Surg 2016; 42(2):249-250. PMID: 26845540. Full Text

Gordon SC, Porto DA, and Kerr HA. Asymptomatic papules on the lateral aspects of the hands and feet J Am Acad Dermatol 2016; 74(4):e55-56. PMID: 26979365. Full Text

36 Hamzavi IH, Zarbo A, and Lim HW. Reply to: "Re: Comorbid autoimmune diseases in patients with vitiligo: A cross- sectional study" J Am Acad Dermatol 2016; 75(6):e233. PMID: 27846973. Full Text

Hanifin JM, Ellis CN, Frieden IJ, Folster-Holst R, Stein Gold LF, Secci A, Smith AJ, Zhao C, Kornyeyeva E, and Eichenfield LF. OPA-15406, a novel, topical, nonsteroidal, selective phosphodiesterase-4 (PDE4) inhibitor, in the treatment of adult and adolescent patients with mild to moderate atopic dermatitis (AD): A phase-II randomized, double-blind, placebo-controlled study J Am Acad Dermatol 2016;PMID: 27189825. Full Text

Huizenga T, Riyaz F, and Ozog DM. Implantable body jewelry and methods for their removal Dermatol Surg 2016;PMID: 27984327. Full text

Isaacs SR, Wang J, Kim KW, Yin C, Zhou L, Mi QS, and Craig ME. MicroRNAs in type 1 diabetes: Complex interregulation of the immune system, beta cell function and viral infections Curr Diab Rep 2016; 16(12):133. PMID: 27844276. Full Text

Jahnke MN. Vascular Lesions Pediatr Ann 2016; 45(8):e299-305. PMID: 27517358. Article Request Form

Jin Y, Andersen G, Yorgov D, Ferrara TM, Ben S, Brownson KM, Holland PJ, Birlea SA, Siebert J, Hartmann A, Lienert A, van Geel N, Lambert J, Luiten RM, Wolkerstorfer A, Wietze van der Veen JP, Bennett DC, Taieb A, Ezzedine K, Kemp EH, Gawkrodger DJ, Weetman AP, Koks S, Prans E, Kingo K, Karelson M, Wallace MR, McCormack WT, Overbeck A, Moretti S, Colucci R, Picardo M, Silverberg NB, Olsson M, Valle Y, Korobko I, Bohm M, Lim HW, Hamzavi I, Zhou L, Mi QS, Fain PR, Santorico SA, and Spritz RA. Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants Nat Genet 2016; 48(11):1418-1424. PMID: 27723757. Full Text

Kannan S, Mehta D, and Ozog D. Scalp closures with pulley sutures reduce time and cost compared to traditional layered technique-a prospective, randomized, observer-blinded study Dermatol Surg 2016; 42(11):1248-1255. PMID: 27598452. Full Text

Kircik L, Sung JC, Stein-Gold L, and Goldenberg G. United states food and drug administration product label changes J Clin Aesthet Dermatol 2016; 9(1):39-48. PMID: 26962391. Full Text

Kouba DJ, LoPiccolo MC, Alam M, Bordeaux JS, Cohen B, Hanke CW, Jellinek N, Maibach HI, Tanner JW, Vashi N, Gross KG, Adamson T, Begolka WS, and Moyano JV. Guidelines for the use of local anesthesia in office-based dermatologic surgery J Am Acad Dermatol 2016;PMID: 26951939. Full Text

Lim HW. Challenges in photoprotection: Introduction J Am Acad Dermatol 2016;PMID: 28038890. Full text

Lim HW, Arellano-Mendoza MI, and Stengel F. Current challenges in photoprotection J Am Acad Dermatol 2016;PMID: 28038886. Full text

Lindow JC, Wunder EA, Jr., Popper SJ, Min JN, Mannam P, Srivastava A, Yao Y, Hacker KP, Raddassi K, Lee PJ, Montgomery RR, Shaw AC, Hagan JE, Araujo GC, Nery N, Jr., Relman DA, Kim CC, Reis MG, and Ko AI. Cathelicidin insufficiency in patients with fatal leptospirosis PLoS Pathog 2016; 12(11):e1005943. PMID: 27812211. Full text

Liu Q, Wu D, Han L, Deng J, Zhou L, He R, Lu C, and Mi QS. Roles of MicroRNAs in psoriasis: immunological functions and potential biomarkers Exp Dermatol 2016;PMID: 27783430. Full Text

Liu Z, Wang S, Mi QS, and Dong Z. MicroRNAs in pathogenesis of acute kidney injury Nephron 2016;PMID: 27322758. Full Text

Madigan LM, and Lim HW. Tanning beds: Impact on health, and recent regulations Clin Dermatol 2016; 34(5):640- 648. PMID: 27638445. Full Text

37 Madigan LM, Treyger G, and Kohen LL. Compliance with serial dermoscopic monitoring: An academic perspective J Am Acad Dermatol 2016;PMID: 27665211. Full Text

Mahmoud BH, Ozog D, Burnett C, and Cohen JL. Prospective randomized split-face comparative study between topical botulinum toxin a surface application and local injection for crow's feet Dermatol Surg 2016;PMID: 26990256. Full Text

Mehta D, and Lim HW. Ultraviolet B phototherapy for psoriasis: Review of practical guidelines Am J Clin Dermatol 2016;PMID: 26872953. Article Request Form

Miller IM, McAndrew RJ, and Hamzavi I. Prevalence, risk factors, and comorbidities of hidradenitis suppurativa Dermatol Clin 2016; 34(1):7-16. PMID: 26617352. Full Text

Modh A, McHargue CA, Lim H, and Siddiqui F. Single-fraction radiation therapy provides highly effective palliation for cutaneous t-cell lymphoma Int J Radiat Oncol Biol Phys 2016; 96(2s):E492. PMID: 27674835. Full Text

Mohammad TF, and Hamzavi IH. Practice and educational gaps in abnormal pigmentation Dermatol Clin 2016; 34(3):291-301. PMID: 27363886. Full Text

Naka F, Shwayder TA, and Santoro FA. Photodermatoses: Kids are not just little people Clin Dermatol 2016; 34(6):724-735. PMID: 27968932. Full text

Nicholson CL, Hamzavi I, and Ozog DM. Rapid healing of chronic ulcerations and improvement in range of motion after fractional carbon dioxide (CO2) treatment after CO2 excision of hidradenitis suppurativa axillary lesions: A case report JAAD Case Reports 2016; 2(1):4-6. PMID: 27051812 Article Request Form

O'Brien R, Porto DA, Friedman BJ, and Douglass MC. Elderly female with swelling of the right breast Ann Emerg Med 2016; 67(6):e25-26. PMID: 27217142. Full Text

Olsen EA, Hodak E, Anderson T, Carter JB, Henderson M, Cooper K, and Lim HW. Guidelines for phototherapy of mycosis fungoides and Sezary syndrome: A consensus statement of the United States Cutaneous Lymphoma Consortium J Am Acad Dermatol 2016; 74(1):27-58. PMID: 26547257. Full Text

Ozog DM, Rkein AM, Fabi SG, Gold MH, Goldman MP, Lowe NJ, Martin GM, and Munavalli GS. Photodynamic therapy: A clinical consensus guide Dermatol Surg 2016; 42(7):804-827. PMID: 27336945. Full Text

Paller AS, Tom WL, Lebwohl MG, Blumenthal RL, Boguniewicz M, Call RS, Eichenfield LF, Forsha DW, Rees WC, Simpson EL, Spellman MC, Stein Gold LF, Zaenglein AL, Hughes MH, Zane LT, and Hebert AA. Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults J Am Acad Dermatol 2016;PMID: 27417017. Full Text

Paul C, Stein Gold L, Cambazard F, Kalb RE, Lowson D, Bang B, and Griffiths CE. Calcipotriol plus betamethasone dipropionate aerosol foam provides superior efficacy vs. gel in patients with psoriasis vulgaris: randomized, controlled PSO-ABLE study J Eur Acad Dermatol Venereol 2016;PMID: 27531752. Full Text

Porto DA, Powers M, Patel D, Chaffins M, and Shwayder TA. Lymphoplasmacytic plaque in children: A demonstrative case of an emerging clinicopathologic entity Pediatr Dermatol 2016;PMID: 27573871. Full Text

Pritchett EN, Doyle A, Shaver CM, Miller B, Abdelmalek M, Cusack CA, Malat GE, and Chung CL. Nonmelanoma skin cancer in nonwhite organ transplant recipients JAMA Dermatol 2016;PMID: 27653769. Full Text

Rosen T, and Stein Gold LF. Antifungal drugs for onychomycosis: Efficacy, safety, and mechanisms of action Semin Cutan Med Surg 2016; 35(3 Suppl 3):S51-55. PMID: 27074700. Article Request Form

38 Siddiqui K, Stein Gold L, and Gill J. The efficacy, safety, and tolerability of ivermectin compared with current topical treatments for the inflammatory lesions of rosacea: a network meta-analysis Springerplus 2016; 5(1):1151. PMID: 27504249. Full Text

Silpa-archa N, Griffith JL, Williams MS, Lim HW, and Hamzavi IH. Prospective comparison of recipient-site preparation with fractional carbon dioxide laser vs. dermabrasion and recipient-site dressing composition in melanocyte-keratinocyte transplantation procedure in vitiligo: A preliminary study Br J Dermatol 2016;PMID: 26409069. Full Text

St Louis D, Romero R, Plazyo O, Arenas-Hernandez M, Panaitescu B, Xu Y, Milovic T, Xu Z, Bhatti G, Mi QS, Drewlo S, Tarca AL, Hassan SS, and Gomez-Lopez N. Invariant NKT cell activation induces late preterm birth that is attenuated by rosiglitazone J Immunol 2016; 196(3):1044-1059. PMID: 26740111. Full Text

Stein Gold L, Weiss J, Rueda MJ, Liu H, and Tanghetti E. Moderate and severe inflammatory acne vulgaris effectively treated with single-agent therapy by a new fixed-dose combination adapalene 0.3 %/benzoyl peroxide 2.5 % gel: A randomized, double-blind, parallel-group, controlled study Am J Clin Dermatol 2016;PMID: 26945741. Article Request Form

Stein Gold LF. Understanding onychomycosis resolving diagnostic dilemmas Semin Cutan Med Surg 2016; 35(3 Suppl 3):S48-50. PMID: 27074698. Article Request Form

Stein Gold LF. Topical therapies for psoriasis: Improving management strategies and patient adherence Semin Cutan Med Surg 2016; 35(2 Suppl 2):S36-44; quiz S45. PMID: 27074696. Article Request Form

Stein Gold LF. Introduction Semin Cutan Med Surg 2016; 35(2 Suppl 2):S35.PMID:27074694. Article Request Form

Stein Gold LF. Acne: What's new Semin Cutan Med Surg 2016; 35(6 Suppl):S114- 116. PMID: 27538054. Article Request Form

Stein Gold L, Baldwin H, Rueda MJ, Kerrouche N, and Dréno B. Adapalene-benzoyl peroxide gel is efficacious and safe in adult female acne, with a profile comparable to that seen in teen-aged females J Clin Aesthet Dermatol 2016; 9(7):23-29. PMID: Not assigned. Article Request Form

Stein Gold L, Villumsen J, and Rosen M. Calcipotriol plus betamethasone dipropionate aerosol foam is effective, independent of body mass index and the extent and severity of psoriasis Dermatol Ther (Heidelb) 2016;PMID: 27714595. Article request form

Taieb A, Stein Gold L, Feldman SR, Dansk V, and Bertranou E. Cost-effectiveness of ivermectin 1% cream in adults with papulopustular rosacea in the United States J Manag Care Spec Pharm 2016; 22(6):654-665. PMID: 27231793. Full Text

Vyas NS, Kannan S, M NJ, Hu RH, Choate KA, and Shwayder TA. Congenital ichthyosiform erythroderma superimposed with chronic dermatophytosis: A report of three siblings Pediatr Dermatol 2016; 33(1):e6-9. PMID: 26645853. Full Text

Wang SQ, Virmani P, and Lim HW. Consumer acceptability and compliance: the next frontier in sunscreen innovation Photodermatol Photoimmunol Photomed 2016; 32(1):55-56. PMID: 26409211. Full Text

Wei Q, Liu Y, Liu P, Hao J, Liang M, Mi QS, Chen JK, and Dong Z. MicroRNA-489 induction by hypoxia-inducible factor-1 protects against ischemic kidney injury J Am Soc Nephrol 2016;PMID: 26975439. Full Text

Wu D, Bi X, Qu L, Han L, Yin C, Deng J, Dong Z, Mi QS, and Zhou L. miRNA miR-17-92 cluster is differentially regulated in the imiqumod-treated skin but is not required for imiqumod-induced psoriasis-like dermatitis in mice Exp Dermatol 2016;PMID: 27579777. Full Text

39

Yan C, Gao N, Sun H, Yin J, Lee P, Zhou L, Fan X, and Yu FS. Targeting imbalance between il- 1beta and il-1 receptor antagonist ameliorates delayed epithelium wound healing in diabetic mouse corneas Am J Pathol 2016; 186(6):1466-1480. PMID: 27109611. Full Text

Yew YW, Giordano CN, Spivak G, and Lim HW. Understanding photodermatoses associated with defective DNA repair: Photosensitive syndromes without associated cancer predisposition J Am Acad Dermatol 2016; 75(5):873- 882. PMID: 27745642. Full Text

Yin C, Weiland M, Miao ZM, Li C, Zhou L, and Mi QS. Deletion of microRNA miR-146a does not prevent streptozotocin-induced murine autoimmune type 1 diabetes Diabetes Metab 2016;PMID: 27133137. Full Text

Zabetian S, Friedman BJ, and McHargue C. A case of idiopathic granulomatous mastitis associated with erythema nodosum, arthritis, and reactive cough JAAD Case Rep 2016; 2(2):125- 127. PMID: 27051851. Full Text

Zaenglein AL, Pathy AL, Schlosser BJ, Alikhan A, Baldwin HE, Berson DS, Bowe WP, Graber EM, Harper JC, Kang S, Keri JE, Leyden JJ, Reynolds RV, Silverberg NB, Stein Gold LF, Tollefson MM, Weiss JS, Dolan NC, Sagan AA, Stern M, Boyer KM, and Bhushan R. Guidelines of care for the management of acne vulgaris J Am Acad Dermatol 2016;PMID: 26897386. Full Text

Zane LT, Chanda S, Jarnagin K, Nelson DB, Spelman L, and Gold LS. Crisaborole and its potential role in treating atopic dermatitis: overview of early clinical studies Immunotherapy 2016;PMID: 27283509. Article Request Form

Zarbo A, Ouerfelli O, Klang M, and Lacouture ME. Increased airport scrutiny by the transportation security administration of a patient-passenger carrying ammonium lactate-containing moisturizer JAMA Dermatol 2016;PMID: 27486908. Full Text

Zarbo A, Belum VR, Sibaud V, Oudard S, Postow MA, Hsieh JJ, Motzer RJ, Busam KJ, and Lacouture ME. Immune- related alopecia (areata and universalis-type) in cancer patients receiving immune checkpoint inhibitors Br J Dermatol 2016;PMID: 27943234. Full text

Zhang L, Yang M, Mayer T, Johnstone B, Les C, Frisch N, Parsons T, Mi QS, and Gibson G. Use of MicroRNA biomarkers to distinguish enchondroma from low-grade chondrosarcoma Connect Tissue Res 2016:1-7. PMID: 27267924. Article Request Form

Zhang X, Gu J, Yu FS, Zhou L, and Mi QS. TGF-beta1-induced transcription factor networks in Langerhans cell development and maintenance Allergy 2016;PMID: 26948524. Full Text

Zhang X, Liu Q, Wang J, Li G, Weiland M, Yu FS, Mi QS, Gu J, and Zhou L. TIM-4 is differentially expressed in the distinct subsets of dendritic cells in skin and skin-draining lymph nodes and controls skin Langerhans cell homeostasis Oncotarget 2016; 7(25):37498-37512. PMID: 27224924. Full Text

Zhang X, Gu J, Zhou L, and Mi QS. TIM-4 is expressed on invariant NKT cells but dispensable for their development and function Oncotarget 2016;PMID: 27662666. Full Text

40 DIAGNOSTIC RADIOLOGY

Ali R, Khan M, Chang V, Narang J, Jain R, Marin H, Rock J, and Kole M. MRI pre- and post- embolization enhancement patterns predict surgical outcomes in intracranial meningiomas J Neuroimaging 2016; 26(1):130-135. PMID: 25996574. Article Request Form

Baumer TG, Chan D, Mende V, Dischler J, Zauel R, van Holsbeeck M, Siegal DS, Divine G, Moutzouros V, and Bey MJ. Effects of rotator cuff pathology and physical therapy on in vivo shoulder motion and clinical outcomes in patients with a symptomatic full-thickness rotator cuff tear Orthop J Sports Med 2016; 4(9)PMID: 27734020. Full Text

Becker MD, Butler PF, Bhargavan-Chatfield M, Harkness BA, Metter D, MacFarlane CR, Ghesani M, Wilcox P, and Oates ME. Adult gamma camera myocardial perfusion imaging: Diagnostic reference levels and achievable administered activities derived from ACR accreditation data J Am Coll Radiol 2016; 13(6):688-695. PMID: 27131619. Full Text

Becker-Weidman DJ, Malhotra N, Reilly DF, Selvam N, Parker L, and Nazarian LN. Imaging surveillance in patients after a benign fine-needle aspiration biopsy of the thyroid: Associated cost and incidence of subsequent cancer AJR Am J Roentgenol 2016:1-4. PMID: 27929675. Full text

Griffith B, and Jain R. Perfusion imaging in neuro-oncology: Basic techniques and clinical applications Magn Reson Imaging Clin N Am 2016; 24(4):765-779. PMID: 27742116. Full Text

Harkness BA, and Fahey FH. A report on the current state of nuclear medicine physics training: The findings of the AAPM/SNMMI joint task force J Nucl Med 2016;PMID: 26966159. Full Text

Hosseini MP, Nazem-Zadeh MR, Pompili D, Jafari-Khouzani K, Elisevich K, and Soltanian-Zadeh H. Comparative performance evaluation of automated segmentation methods of hippocampus from magnetic resonance images of temporal lobe epilepsy patients Med Phys 2016; 43(1):538. PMID: 26745947. Article Request Form

Kabbani L, Balraj P, Mathews J, Tinney F, Jr., Schwartz S, Kwon D, Braun F, and Wasilenko S. Epithelioid hemangioendothelioma presenting as inferior vena cava obstruction diagnosed using an endovascular thrombectomy device Ann Vasc Surg 2016;PMID: 28012782. Full text

Keller RA, Marshall NE, Bey MJ, Ahmed H, Scher CE, van Holsbeeck M, and Moutzouros V. Pre- and postseason dynamic ultrasound evaluation of the pitching elbow Arthroscopy 2015; 31(9):1708- 1715. PMID: 26354194. Full Text

Mendiratta-Lala M, Park H, Kolicaj N, Mendiratta V, and Bassi D. Small intrahepatic peripheral cholangiocarcinomas as mimics of hepatocellular carcinoma in multiphasic CT Abdom Radiol (NY) 2016;PMID: 27590067. Article Request Form

Nazem-Zadeh MR, Elisevich K, Air EL, Schwalb JM, Divine G, Kaur M, Wasade VS, Mahmoudi F, Shokri S, Bagher-Ebadian H, and Soltanian-Zadeh H. DTI-based response-driven modeling of mTLE laterality Neuroimage Clin 2016; 11:694-706. PMID: 27330966. Full Text

Nelson F, Bokhari O, Oravec D, Kim W, Flynn M, Lumley C, McPhilamy A, and Yeni YN. The use of tomosynthesis in the global study of knee subchondral insufficiency fractures Acad Radiol 2016;PMID: 28010915. Full text

Newman LA, Stark A, Chitale D, Pepe M, Longton G, Worsham MJ, Nathanson SD, Miller P, Bensenhaver JM, Proctor E, Swain M, Patriotis C, and Engstrom PF. Association between benign breast disease in african american and white american women and subsequent triple-negative breast cancer JAMA Oncol 2016;PMID: 28006062. Full text

Parikh Y, Sharma KJ, Parikh SJ, and Hall D. Intramammary schwannoma: a palpable breast mass Radiol Case Rep 2016; 11(3):129-133. PMID: 27594933. Full Text

41 Petrazko A, Siegal D, Flynn M, Rao SD, Peterson E, and van Holsbeeck M. The advantages of tomosynthesis for evaluating bisphosphonate-related atypical femur fractures compared to radiography Skeletal Radiol 2016;PMID: 26861160. Full Text

Petraszko A, Siegal D, Flynn M, Rao SD, Peterson E, and van Holsbeeck M. Erratum to: The advantages of tomosynthesis for evaluating bisphosphonate-related atypical femur fractures compared to radiography Skeletal Radiol 2016;PMID: 26899141. Full Text

Pinkney DM, Mychajlowycz M, and Shah BA. A prospective comparative study to evaluate the displacement of four commercially available breast biopsy markers Br J Radiol 2016; 89(1065):20160149. PMID: 27376410. Full Text

Rheinboldt M, Delproposto Z, Blase J, and Hakim B. Acute presentation of lhermitte-duclos disease in adult patient in association with cowden syndrome Appl Radiol 2016; 45(8):28-31. PMID: Not assigned.Article Request Form

Rheinboldt M, and Scher C. Musculoskeletal ultrasonography in the diagnosis of acute crystalline synovitis Emerg Radiol 2016;PMID: 27439716. Full Text

Riaz RM, Myers DT, and Williams TR. Multidetector CT imaging of bariatric surgical complications: a pictorial review Abdom Radiol 2016; 41(1):174-188. PMID: 26830623. Article Request Form

Schwartz AG, Lusk CM, Wenzlaff AS, Watza D, Pandolfi S, Mantha L, Cote ML, Soubani AO, Walworth G, Wozniak A, Neslund-Dudas C, Ardisana AA, Flynn MJ, Song T, Spizarny DL, Kvale PA, Chapman RA, and Gadgeel SM. Risk of lung cancer associated with COPD phenotype based on quantitative image analysis Cancer Epidemiol Biomarkers Prev 2016; 25(9):1341-1347. PMID: 27383774. Article Request Form

Sever A, and Rheinboldt M. Unstable abdominal aortic aneurysms: a review of MDCT imaging features Emerg Radiol 2016;PMID: 26797025. Full Text

Shah BA, Sever A, and Cressman S. Breast imaging BINGO: an educational game to supplement the traditional assessment style Med Sci Educ 2016:1-5. PMID: Not assigned. Article Request Form

Siegal D, Davis L, Scheer M, and Walker L. Entrapment neuropathies of the upper extremity nerves Current Radiology Reports 2016; 4(12)PMID: Not assigned. Article Request Form

Spain JA, Rheinboldt M, Parrish D, and Rinker E. Morel-lavallée injuries. A multimodality approach to imaging characteristics Academic Radiology 2016;PMID: Not assigned. Full text

Spain J, and Rheinboldt M. MDCT of pelvic inflammatory disease: a review of the pathophysiology, gamut of imaging findings, and treatment Emerg Radiol 2016;PMID: 27646971. Full Text

Tahir RA, Asmaro K, Pabaney A, Kole M, Nypaver T, and Marin H. Separate origins of the left internal and external carotid arteries from the aortic arch and cervical internal carotid artery aneurysm in a patient with Noonan syndrome J Neurointerv Surg 2016;PMID: 27466463. Full Text

Wang DD, Eng M, Greenbaum A, Myers E, Forbes M, Pantelic M, Song T, Nelson C, Divine G, Taylor A, Wyman J, Guerrero M, Lederman RJ, Paone G, and O'Neill W. Predicting LVOT Obstruction After TMVR JACC Cardiovasc Imaging 2016;PMID: 27209112. Full Text

Wang DD, Eng M, Kupsky D, Myers E, Forbes M, Rahman M, Zaidan M, Parikh S, Wyman J, Pantelic M, Song T, Nadig J, Karabon P, Greenbaum A, and O'Neill W. Application of 3- dimensional computed tomographic image guidance to WATCHMAN implantation and impact on early operator learning curve: Single-center experience JACC Cardiovasc Interv 2016; 9(22):2329- 2340. PMID: 27884358. Full Text

42 Wasade VS, Balki I, Bowyer SM, Gaddam S, Mohammadi-Nejad AR, Nazem-Zadeh MR, Soltanian-Zadeh H, Zillgitt A, and Spanaki-Varelas M. Controllable yawning expressed as focal seizures of frontal lobe epilepsy Epilepsy Behav Case Rep 2016; 6:61-63. PMID: 27668178. Full Text

Zdrenghea M, Bagacean C, Renaudineau Y, Salaun PY, Marin H, Pop D, and Tempescul A. Isolated cardiac richter syndrome: A case report Ann Hematol 2016;PMID: 27696201. Full Text

43 EMERGENCY MEDICINE

Baker-Genaw K, Kokas MS, Ahsan SF, Darnley-Fisch D, Drake S, Goyal N, Inamdar K, Moutzouros V, Prabhakar D, Rolland L, Sangha R, Shreve M, and Woodward A. Mapping direct observations from objective structured clinical examinations to the milestones across specialties J Grad Med Educ 2016; 8(3):429-434. PMID: 27413450. Full Text

Belsky JB, Morris DC, Bouchebl R, Filbin MR, Bobbitt KR, Jaehne AK, and Rivers EP. Plasma levels of F-actin and F:G-actin ratio as potential new biomarkers in patients with septic shock Biomarkers 2016:1-6. PMID: 26754286. Article Request Form

Beri N, Marston NA, Daniels LB, Nowak RM, Schreiber D, Mueller C, Jaffe A, Diercks DB, Wettersten N, DeFilippi C, Peacock WF, Limkakeng AT, Anand I, McCord J, Hollander JE, Wu AH, Apple FS, Nagurney JT, Berardi C, Cannon CM, Clopton P, Neath SX, Christenson RH, Hogan C, Vilke G, and Maisel A. Necessity of hospitalization and stress testing in low risk chest pain patients Am J Emerg Med 2016;PMID: 27847253. Full Text

Body R, Mueller C, Giannitsis E, Christ M, Ordonez-Llanos J, de Filippi CR, Nowak R, Panteghini M, Jernberg T, Plebani M, Verschuren F, French JK, Christenson R, Weiser S, Bendig G, Dilba P, and Lindahl B. The use of very low concentrations of high sensitivity troponin T to rule out acute myocardial infarction using a single blood test Acad Emerg Med 2016;PMID: 27178492. Full Text

Bou Chebl R, Madden B, Belsky J, Harmouche E, and Yessayan L. Diagnostic value of end tidal capnography in patients with hyperglycemia in the emergency department BMC Emerg Med 2016; 16(1):7. PMID: 26821648. Full Text

Chess LE, and Gagnier JJ. Applicable or non-applicable: investigations of clinical heterogeneity in systematic reviews BMC Med Res Methodol 2016; 16(1):19. PMID: 26883215. Full Text

Goodwin M, Ito K, Gupta AH, and Rivers EP. Protocolized care for early shock resuscitation Curr Opin Crit Care 2016; 22(5):416-423. PMID: 27583584. Full Text

Goyal N, Taylor AR, and Rivers EP. Relationship between central and peripheral venous oxygen saturation and lactate levels: A prospective study J Emerg Med 2016;PMID: 27210904. Full Text

Goyal N, Vallee PA, Folt J, Jaskulka B, Baliga S, Nagarwala J, and Slezak M. WIREd for milestones J Grad Med Educ 2016; 8(3):445-446. PMID: 27413456. Full Text

Grudzen CR, Emlet LL, Kuntz J, Shreves A, Zimny E, Gang M, Schaulis M, Schmidt S, Isaacs E, and Arnold R. EM Talk: communication skills training for emergency medicine patients with serious illness BMJ Support Palliat Care 2016;PMID: 26762163. Article Request Form

Harrison MF, Anderson PJ, Johnson JB, Richert M, Miller AD, and Johnson BD. Acute mountain sickness symptom severity at the south pole: The influence of self-selected prophylaxis with acetazolamide PLoS One 2016; 11(2):e0148206. PMID: 26848757. Full Text

Harrison MF, Forde KA, Albert WJ, Croll JC, and Neary JP. Posture and helmet load influences on neck muscle activation Aerosp Med Hum Perform 2016; 87(1):48-53. PMID: 26735233. Article Request Form

Harrison MF, and Johnson BD. Letter to the editor re: Use of statins for prophylaxis against acute mountain sickness: Response Aerosp Med Hum Perform 2016; 87(2):148-149. PMID: 26802382. Article Request Form

Hasegawa K, Brenner BE, Nowak RM, Trent SA, Herrera V, Gabriel S, Bittner JC, and Camargo CA, Jr. Association of guideline-concordant acute asthma care in the emergency department with shorter hospital length-of-stay: A multicenter observational study Acad Emerg Med 2016;PMID: 26833429. Full Text

Hermann G, Xi AS, Stevens B, and Goyal N. Reducing errors in reporting scholarly activity to the ACGME: The annual update scholarly activity monitoring tool J Grad Med Educ 2016; 8(3):447-448. PMID: 27413457. Full Text

44 Hourmozdi JJ, Markin A, Johnson B, Fleming PR, and Miller JB. Routine chest radiography is not necessary after ultrasound-guided right internal jugular vein catheterization Crit Care Med 2016;PMID: 27035241. Full Text

Jaehne AK, Jayaprakash N, and Langberg S. Defining septic shock Jama 2016; 316(4):455. PMID: 27458956. Full Text

Jaehne AK, and Rivers EP. Early liberal fluid therapy for sepsis patients is not harmful: Hydrophobia is unwarranted but drink responsibly Crit Care Med 2016;PMID: 27749314. Full Text

Jain T, Nowak R, Hudson M, Frisoli T, Jacobsen G, and McCord J. Short- and long-term prognostic utility of the HEART score in patients evaluated in the emergency department for possible acute coronary syndrome Crit Pathw Cardiol 2016; 15(2):40-45. PMID: 27183252. Full Text

Linnstaedt SD, Hu J, Liu AY, Soward AC, Bollen KA, Wang HE, Hendry PL, Zimny E, Lewandowski C, Velilla MA, Damiron K, Pearson C, Domeier R, Kaushik S, Feldman J, Rosenberg M, Jones J, Swor R, Rathlev N, and McLean SA. Methodology of AA CRASH: a prospective observational study evaluating the incidence and pathogenesis of adverse post-traumatic sequelae in African-Americans experiencing motor vehicle collision BMJ Open 2016; 6(9):e012222. PMID: 27601501. Full Text

Macedo M, Kim B, Khoury R, and Narkiewicz L. A rare case of right lower quadrant abdominal pain Am J Emerg Med 2016;PMID: 27842925. Full Text

Maisel AS, Wettersten N, van Veldhuisen DJ, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos MC, Cannon CM, Muller GA, Birkhahn R, Clopton P, Taub P, Vilke GM, McDonald K, Mahon N, Nunez J, Briguori C, Passino C, and Murray PT. Neutrophil gelatinase-associated lipocalin for acute kidney injury during acute heart failure hospitalizations: The AKINESIS study J Am Coll Cardiol 2016; 68(13):1420-1431. PMID: 27659464. Full Text

Miller J, Ho CX, Tang J, Thompson R, Goldberg J, Amer A, and Nahab B. Assessing fluid responsiveness in spontaneously breathing patients Acad Emerg Med 2016;PMID: 26764894. Full Text

Miller JB, Kinni H, Amer A, and Levy PD. Therapies to reduce blood pressure acutely Curr Hypertens Rep 2016; 18(6):43. PMID: 27125389. Full Text

Miller JB, Lewandowski C, Wira CR, Taylor A, Burmeister C, and Welch R. Volume of plasma expansion and functional outcomes in stroke Neurocrit Care 2016;PMID: 27629275. Full Text

Miller JB, Merck LH, Wira CR, Meurer WJ, Schrock JW, Nomura JT, Siket MS, Madsen TE, Wright DW, Panagos PD, and Lewandowski C. The advanced reperfusion era: Implications for emergency systems of ischemic stroke care Ann Emerg Med 2016;PMID: 27600649. Full Text

Nagarwala J, Dev S, and Markin A. The vomiting patient: Small bowel obstruction, cyclic vomiting, and gastroparesis Emerg Med Clin North Am 2016; 34(2):271-291. PMID: 27133244. Full Text

Nowak RM, Reed BP, Nanayakkara P, DiSomma S, Moyer ML, Millis S, and Levy P. Presenting hemodynamic phenotypes in ED patients with confirmed sepsis Am J Emerg Med 2016;PMID: 27613360. Full Text

Nowak RM, Reed BP, DiSomma S, Nanayakkara P, Moyer M, Millis S, and Levy P. Presenting phenotypes of acute heart failure patients in the emergency department: Identification and implications Am J Emerg Med 2016;PMID: 27986335. Full text

Nguyen HB, Jaehne AK, Jayaprakash N, Semler MW, Hegab S, Yataco AC, Tatem G, Salem D, Moore S, Boka K, Gill JK, Gardner-Gray J, Pflaum J, Domecq JP, Hurst G, Belsky JB, Fowkes R, Elkin RB, Simpson SQ, Falk JL, Singer DJ, and Rivers EP. Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE Crit Care 2016; 20(1):160. PMID: 27364620. Full Text

45 O'Brien PD, Hur J, Robell NJ, Hayes JM, Sakowski SA, and Feldman EL. Gender-specific differences in diabetic neuropathy in BTBR ob/ob mice J Diabetes Complications 2016; 30(1):30- 37. PMID: 26525588. Full Text

Rooney KP, Lahham S, Lahham S, Anderson CL, Bledsoe B, Sloane B, Joseph L, Osborn MB, and Fox JC. Pre- hospital assessment with ultrasound in emergencies: implementation in the field World J Emerg Med 2016; 7(2):117- 123. PMID: 27313806. Full Text

Sachwani GR, Jaehne AK, Jayaprakash N, Kuzich M, Onkoba V, Blyden D, and Rivers EP. The association between blood glucose levels and matrix-metalloproteinase-9 in early severe sepsis and septic shock J Inflamm (Lond) 2016; 13:13. PMID: 27110221. Full Text

Skupski R, Miller J, Binz S, Lapkus M, and Walsh M. Delayed sequence intubation: Danger in delaying definitive airway? Ann Emerg Med 2016; 67(1):143-144. PMID: 26707526. Full Text

Storrow AB, Christenson RH, Nowak RM, Diercks DB, Singer AJ, Wu AH, Kulstad E, LoVecchio F, Fromm C, Headden G, Potis T, Hogan CJ, Schrock JW, Zelinski DP, Greenberg MR, Ritchie JC, Chamberlin JS, Bray KR, Rhodes DW, Trainor D, Holmes D, and Southwick PC. Diagnostic performance of cardiac Troponin I for early rule-in and rule-out of acute myocardial infarction: Results of a prospective multicenter trial Clin Biochem 2015; 48(4-5):254-259. PMID: 25195101. Article Request Form

Townsend SR, Rivers E, and Tefera L. Definitions for sepsis and septic shock Jama 2016; 316(4):457- 458. PMID: 27458959. Full Text

Tsalik EL, Henao R, Nichols M, Burke T, Ko ER, McClain MT, Hudson LL, Mazur A, Freeman DH, Veldman T, Langley RJ, Quackenbush EB, Glickman SW, Cairns CB, Jaehne AK, Rivers EP, Otero RM, Zaas AK, Kingsmore SF, Lucas J, Fowler VG, Jr., Carin L, Ginsburg GS, and Woods CW. Host gene expression classifiers diagnose acute respiratory illness etiology Sci Transl Med 2016; 8(322):322ra311. PMID: 26791949. Article Request Form

Wilson SP, and Nowak RM. Excluding acute aortic dissection: The need for a reliable biomarker Heart Lung 2016;PMID: 26948698. Full Text

Wilson S, Dev S, Mahan M, Malhotra M, and Miller J. Identifying disparity in emergency department length of stay and admission likelihood World J Emerg Med 2016; 7(2):111-116. PMID: 27313805. Full Text

46 FAMILY MEDICINE

Baker-Genaw K, Kokas MS, Ahsan SF, Darnley-Fisch D, Drake S, Goyal N, Inamdar K, Moutzouros V, Prabhakar D, Rolland L, Sangha R, Shreve M, and Woodward A. Mapping direct observations from objective structured clinical examinations to the milestones across specialties J Grad Med Educ 2016; 8(3):429-434. PMID: 27413450. Full Text

Budzynska K, Filippelli AC, Sadikova E, Low Dog T, and Gardiner P. Use and factors associated with herbal/botanical and nonvitamin/nonmineral dietary supplements among women of reproductive age: An analysis of the infant feeding practices study II J Midwifery Womens Health 2016; 61(4):419- 426. PMID: 27336953. Full Text

Holm AL, Rowe Gorosh M, Brady M, and White-Perkins D. Recognizing privilege and bias: An interactive exercise to expand health care providers' personal awareness Acad Med 2016;PMID: 27355785. Full Text

Park B, and Choo SH. The burden of prostatic calculi is more important than the presence Asian J Androl 2016;PMID: 27184549. Full Text

47 GLOBAL HEALTH INITIATIVE

Kaljee L, Zhang L, Langhaug L, Munjile K, Tembo S, Menon A, Stanton B, Li X, and Malungo J. A randomized- control trial for the teachers' diploma programme on psychosocial care, support and protection in Zambian government primary schools Psychol Health Med 2016:1-12. PMID: 26965476. Article Request Form

Kaljee L, and Rick S. Zimmerman (Editor) RJDE, Jon K. Andrus (Editor), Everold N. Hosein (Editor). Implementation of public health innovations in developing countries Introduction to global health promotion. San Francisco, CA: Jossey-Bass 2016;PMID: Not assigned, Book Chapter. Article Request Form

Kaljee LM, Kilgore P, Prentiss T, Lamerato L, Moreno D, Arshad S, and Zervos M. 'You need to be an advocate for yourself': Factors associated with decision-making regarding influenza and pneumococcal vaccine use among U.S. older adults from within a large metropolitan health system Hum Vaccin Immunother 2016:0. PMID: 27625007. Article Request Form

Kilgore PE, Salim AM, Zervos MJ, and Schmitt HJ. Pertussis: Microbiology, disease, treatment, and prevention Clin Microbiol Rev 2016; 29(3):449-486. PMID: 27029594. Article Request Form

W. B, and Parke D. Official development assistance and women's rights: How aid donor characteristics affect women's rights improvement in recipient countries Asian Women 2016; 32(1):1-29. PMID: Not assigned. Article Request Form Part of first author name is missing

GRADUATE MEDICAL EDUCATION

Baker-Genaw K, Kokas MS, Ahsan SF, Darnley-Fisch D, Drake S, Goyal N, Inamdar K, Moutzouros V, Prabhakar D, Rolland L, Sangha R, Shreve M, and Woodward A. Mapping direct observations from objective structured clinical examinations to the milestones across specialties J Grad Med Educ 2016; 8(3):429-434. PMID: 27413450. Full Text

Hermann G, Xi AS, Stevens B, and Goyal N. Reducing errors in reporting scholarly activity to the ACGME: The annual update scholarly activity monitoring tool J Grad Med Educ 2016; 8(3):447-448. PMID: 27413457. Full Text

Sanford B, Whitehouse S, and Kokas M. Do acgme physician-patient communication milestones align with hcahps patient satisfaction measures for doctor communication? Am J Med Qual 2016;PMID: 27259872. Full Text

48 INTERNAL MEDICINE

Allergy and Immunology

Cassidy-Bushrow AE, Wegienka G, Havstad S, Levin AM, Lynch SV, Ownby DR, Rundle AG, Woodcroft KJ, Zoratti EM, and Johnson CC. Race-specific association of caesarean-section delivery with body size at age 2 years Ethn Dis 2016; 26(1):61-68. PMID: 26843797. Article Request Form

Frieder J, and Younus M. Autoimmune progesterone dermatitis with delayed intradermal skin reaction: A case report Ann Allergy Asthma Immunol 2016;PMID: 27566859. Full Text

Fujimura KE, Sitarik AR, Havstad S, Lin DL, Levan S, Fadrosh D, Panzer AR, LaMere B, Rackaityte E, Lukacs NW, Wegienka G, Boushey HA, Ownby DR, Zoratti EM, Levin AM, Johnson CC, and Lynch SV. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation Nat Med 2016;PMID: 27618652. Full Text

Joseph CL, Zoratti EM, Ownby DR, Havstad S, Nicholas C, Nageotte C, Misiak R, Enberg R, Ezell J, and Johnson CC. Exploring racial differences in IgE-mediated food allergy in the WHEALS birth cohort Ann Allergy Asthma Immunol 2016;PMID: 26837607. Full Text

Krouse RZ, Sorkness CA, Wildfire JJ, Calatroni A, Gruchalla R, Khurana Hershey GK, Kattan M, Liu AH, Makhija M, Teach SJ, West JB, Wood RA, Zoratti EM, and Gergen PJ. Minimally important differences and risk levels for the composite asthma severity index J Allergy Clin Immunol 2016;PMID: 27744028. Full Text

Levin AM, Sitarik AR, Havstad SL, Fujimura KE, Wegienka G, Cassidy-Bushrow AE, Kim H, Zoratti EM, Lukacs NW, Boushey HA, Ownby DR, Lynch SV, and Johnson CC. Joint effects of pregnancy, sociocultural, and environmental factors on early life gut microbiome structure and diversity Sci Rep 2016; 6:31775. PMID: 27558272. Full Text

Liu AH, Babineau DC, Krouse RZ, Zoratti EM, Pongracic JA, O'Connor GT, Wood RA, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Kattan M, Teach SJ, Makhija M, Pillai D, Lamm CI, Gern JE, Sigelman SM, Gergen PJ, Togias A, Visness CM, and Busse WW. Pathways through which asthma risk factors contribute to asthma severity in inner-city children J Allergy Clin Immunol 2016; 138(4):1042-1050. PMID: 27720018. Full Text

Pongracic JA, Krouse RZ, Babineau DC, Zoratti EM, Cohen RT, Wood RA, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Kattan M, Teach SJ, Johnson CC, Bacharier LB, Gern JE, Sigelman SM, Gergen PJ, Togias A, Visness CM, Busse WW, and Liu AH. Distinguishing characteristics of difficult- to-control asthma in inner-city children and adolescents J Allergy Clin Immunol 2016; 138(4):1030- 1041. PMID: 27720017. Full Text

Wegienka G, Havstad S, Kim H, Zoratti E, Ownby D, Woodcroft KJ, and Johnson CC. Subgroup differences in the associations between dog exposure during the first year of life and early life allergic outcomes Clin Exp Allergy 2016;PMID: 27562398. Full Text

Yang IV, Pedersen BS, Liu AH, O'Connor GT, Pillai D, Kattan M, Misiak RT, Gruchalla R, Szefler SJ, Khurana Hershey GK, Kercsmar C, Richards A, Stevens AD, Kolakowski CA, Makhija M, Sorkness CA, Krouse RZ, Visness C, Davidson EJ, Hennessy CE, Martin RJ, Togias A, Busse WW, and Schwartz DA. The nasal methylome and childhood atopic asthma J Allergy Clin Immunol 2016;PMID: 27745942. Full Text

Zoratti EM, Krouse RZ, Babineau DC, Pongracic JA, O'Connor GT, Wood RA, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Kattan M, Teach SJ, Sigelman SM, Gergen PJ, Togias A, Visness CM, Busse WW, and Liu AH. Asthma phenotypes in inner-city children J Allergy Clin Immunol 2016; 138(4):1016-1029. PMID: 27720016. Full Text

49 Cardiology

Ades PA, Keteyian SJ, Wright JS, Hamm LF, Lui K, Newlin K, Shepard DS, and Thomas RJ. Increasing cardiac rehabilitation participation from 20% to 70%: A road map from the million hearts cardiac rehabilitation collaborative Mayo Clin Proc 2016;PMID: 27855953. Full Text

Al-Mallah MH, Qureshi WT, Keteyian SJ, Brawner CA, Alam M, Dardari Z, Nasir K, and Blaha MJ. Racial differences in the prognostic value of cardiorespiratory fitness (Results from the Henry Ford Exercise Testing Project) Am J Cardiol 2016;PMID: 26976790. Full Text

Al-Mallah MH, Juraschek SP, Whelton S, Dardari ZA, Ehrman JK, Michos ED, Blumenthal RS, Nasir K, Qureshi WT, Brawner CA, Keteyian SJ, and Blaha MJ. Sex differences in cardiorespiratory fitness and all-cause mortality: The henry ford exercise testing (fit) project Mayo Clin Proc 2016; 91(6):755- 762. PMID: 27161032. Full Text

Al Rifai M, Patel J, Hung RK, Nasir K, Keteyian SJ, Brawner CA, Ehrman JK, Sakr S, Blumenthal RS, Blaha MJ, and Al-Mallah MH. Higher fitness is strongly protective in patients with family history of heart disease: The FIT project Am J Med 2016;PMID: 27751899. Full Text

Ananthasubramaniam K, Garikapati K, and Williams CT. Progressive left ventricular hypertrophy after heart transplantation: Insights and mechanisms suggested by multimodal images Tex Heart Inst J 2016; 43(1):65-68. PMID: 27047289. Full Text

Atkinson TM, Ohman EM, O'Neill WW, Rab T, and Cigarroa JE. A practical approach to mechanical circulatory support in patients undergoing percutaneous coronary intervention: An interventional perspective JACC Cardiovasc Interv 2016; 9(9):871-883. PMID: 27151604. Full Text

Bagur R, Teefy PJ, Kiaii B, Goela A, Greenbaum A, and Chu MW. Transcaval transcatheter aortic valve replacement with the ACURATE-neo aortic bioprosthesis: First north american experience JACC Cardiovasc Interv 2016; 9(20):e199-e201. PMID: 27692823. Full Text

Beri N, Marston NA, Daniels LB, Nowak RM, Schreiber D, Mueller C, Jaffe A, Diercks DB, Wettersten N, DeFilippi C, Peacock WF, Limkakeng AT, Anand I, McCord J, Hollander JE, Wu AH, Apple FS, Nagurney JT, Berardi C, Cannon CM, Clopton P, Neath SX, Christenson RH, Hogan C, Vilke G, and Maisel A. Necessity of hospitalization and stress testing in low risk chest pain patients Am J Emerg Med 2016;PMID: 27847253. Full Text

Blaha MJ, Hung RK, Dardari Z, Feldman DI, Whelton SP, Nasir K, Blumenthal RS, Brawner CA, Ehrman JK, Keteyian SJ, and Al-Mallah MH. Age-dependent prognostic value of exercise capacity and derivation of fitness-associated biologic age Heart 2016;PMID: 26732181. Full Text

Blanke P, Naoum C, Ahmadi A, Cheruvu C, Soon J, Arepalli C, Gransar H, Achenbach S, Berman DS, Budoff MJ, Callister TQ, Al-Mallah MH, Cademartiri F, Chinnaiyan K, Rubinshtein R, Marquez H, DeLago A, Villines TC, Hadamitzky M, Hausleiter J, Shaw LJ, Kaufmann PA, Cury RC, Feuchtner G, Kim YJ, Maffei E, Raff G, Pontone G, Andreini D, Chang HJ, Chow BW, Min J, and Leipsic J. Long- term prognostic utility of coronary ct angiography in stable patients with diabetes mellitus JACC Cardiovasc Imaging 2016;PMID: 27568114. Full Text

Brawner CA, Churilla JR, and Keteyian SJ. Prevalence of physical activity is lower among individuals with chronic disease Med Sci Sports Exerc 2016;PMID: 26741117. Full Text

Brawner CA, Abdul-Nour K, Lewis B, Schairer JR, Modi SS, Kerrigan DJ, Ehrman JK, and Keteyian SJ. Relationship between exercise workload during cardiac rehabilitation and outcomes in patients with coronary heart disease Am J Cardiol 2016;PMID: 26897640. Full Text

Brawner CA, Girdano D, Ehrman JK, and Keteyian SJ. Association between phase 3 cardiac rehabilitation and clinical events J Cardiopulm Rehabil Prev 2016;PMID: 27676465. Full Text

Brilakis ES, Karmpaliotis D, Vo MN, Carlino M, Galassi AR, Boukhris M, Alaswad K, Bryniarski L, Lombardi WL, and Banerjee S. Update on coronary chronic total occlusion percutaneous

50 coronary intervention Interventional Cardiology Clinics 2016;PMID: Not assigned. Full Text

Cabrera R, and Ananthasubramaniam K. Diagnosis, therapeutic response assessment, and detection of disease recurrence in cardiac sarcoidosis: Integral role of cardiac PET J Nucl Cardiol 2016;PMID: 26809438. Article Request Form

Cheruvu C, Precious B, Naoum C, Blanke P, Ahmadi A, Soon J, Arepalli C, Gransar H, Achenbach S, Berman DS, Budoff MJ, Callister TQ, Al-Mallah MH, Cademartiri F, Chinnaiyan K, Rubinshtein R, Marquez H, DeLago A, Villines TC, Hadamitzky M, Hausleiter J, Shaw LJ, Kaufmann PA, Cury RC, Feuchtner G, Kim YJ, Maffei E, Raff G, Pontone G, Andreini D, Chang HJ, Min JK, and Leipsic J. Long term prognostic utility of coronary CT angiography in patients with no modifiable coronary artery disease risk factors: Results from the 5 year follow-up of the CONFIRM International Multicenter Registry J Cardiovasc Comput Tomogr 2016; 10(1):22-27. PMID: 26719237. Full Text

Christakopoulos GE, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Wyman RM, Lombardi W, Grantham JA, Kandzari DA, Lembo N, Moses JW, Kirtane A, Parikh M, Green P, Finn M, Garcia S, Doing A, Patel M, Bahadorani J, Christopoulos G, Karatasakis A, Thompson CA, Banerjee S, and Brilakis ES. Contrast utilization during chronic total occlusion percutaneous coronary intervention: Insights from a contemporary multicenter registry J Invasive Cardiol 2016; 28(7):288- 294. PMID: 27342206. Full Text

Christopoulos G, Kotsia AP, Rangan BV, Vo M, Alaswad K, Karmpaliotis D, Banerjee S, and Brilakis ES. "Subintimal external crush" technique for a "balloon uncrossable" chronic total occlusion Cardiovasc Revasc Med 2016;PMID: 27421955. Full Text

Cohen MG, Matthews R, Maini B, Dixon S, Vetrovec G, Wohns D, Palacios I, Popma J, Ohman EM, Schreiber T, and O'Neill WW. Percutaneous left ventricular assist device for high-risk percutaneous coronary interventions: Real-world versus clinical trial experience Am Heart J 2015; 170(5):872-879. PMID: 26542494. Full Text

Collins SP, Levy PD, Martindale JL, Dunlap ME, Storrow AB, Pang PS, Albert NM, Felker GM, Fermann GJ, Fonarow GC, Givertz MM, Hollander JE, Lanfear DJ, Lenihan DJ, Lindenfeld JM, Peacock WF, Sawyer DB, Teerlink JR, and Butler J. Clinical and research considerations for patients with hypertensive acute heart failure: A consensus statement from the society of academic emergency medicine and the heart failure society of america acute heart failure working group J Card Fail 2016;PMID: 27262665. Full Text

Collins SP, Levy PD, Martindale JL, Dunlap ME, Storrow AB, Pang PS, Albert NM, Felker GM, Fermann GJ, Fonarow GC, Givertz MM, Hollander JE, Lanfear DJ, Lenihan DJ, Lindenfeld JM, Frank Peacock W, Sawyer DB, Teerlink JR, and Butler J. Clinical and research considerations for patients with hypertensive acute heart failure aconsensus statement from the society for academic emergency medicine and the heart failure society of america acute heart failure working group Acad Emerg Med 2016;PMID: 27286136. Full Text

Cooper LB, Mentz RJ, Sun JL, Schulte PJ, Fleg JL, Cooper LS, Pina IL, Leifer ES, Kraus WE, Whellan DJ, Keteyian SJ, and O'Connor CM. Psychosocial factors, exercise adherence, and outcomes in heart failure patients: Insights from heart failure: A controlled trial investigating outcomes of exercise training (HF-ACTION) Circ Heart Fail 2015; 8(6):1044-1051. PMID: 26578668. Full Text

Cremer PC, Wu Y, Ahmed HM, Pierson LM, Brennan DM, Al-Mallah MH, Brawner CA, Ehrman JK, Keteyian SJ, Blumenthal RS, Blaha MJ, and Cho L. Use of sex-specific clinical and exercise risk scores to identify patients at increased risk for all-cause mortality JAMA Cardiol 2016;PMID: 27784057. Full Text

Daaboul Y, Korjian S, Weaver WD, Kloner RA, Giugliano RP, Carr J, Neal BJ, Chi G, Cochet M, Goodell L, Michalak N, Rusowicz-Orazem L, Alkathery T, Allaham H, Routray S, Szlosek D, Jain P, and Gibson CM. Relation of left ventricular mass and infarct size in anterior wall st-segment elevation acute myocardial infarction (from the embrace stemi clinical trial) Am J Cardiol 2016; 118(5):625-631. PMID: 27392509. Full text

51 Danek BA, Karatasakis A, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Patel M, Bahadorani J, Lombardi WL, Wyman MR, Grantham JA, Doing A, Moses JW, Kirtane A, Parikh M, Ali ZA, Kalra S, Kandzari DE, Lembo N, Garcia S, Rangan BV, Thompson CA, Banerjee S, and Brilakis ES. Use of antegrade dissection re-entry in coronary chronic total occlusion percutaneous coronary intervention in a contemporary multicenter registry Int J Cardiol 2016; 214:428-437. PMID: 27088405. Full Text

Ellis CR, Dickerman DI, Orton JM, Hassan S, Good ED, Okabe T, Andriulli JA, Quan KJ, and Greenspon AJ. Ampere hour (ah) as a predictor of cardiac resynchronization defibrillator pulse generator battery longevity; a multi-center study Pacing Clin Electrophysiol 2016;PMID: 26875541. Article Request Form

El-Refai M, Hrobowski T, Peterson EL, Wells K, Spertus JA, Williams LK, and Lanfear DE. Race and association of angiotensin converting enzyme/angiotensin receptor blocker exposure with outcome in heart failure J Cardiovasc Med (Hagerstown) 2015; 16(9):591-596. PMID: 24842464. Full Text

Frisoli TM, Friedman H, and O'Neill WW. Rotational atherectomy of three overlapping stent layers J Invasive Cardiol 2016; 28(9):E77-79. PMID: 27591692. Full Text

Garcia S, Chadi Alraies M, Karatasakis A, Yannopoulos D, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel MP, Bahadorani J, Karacsonyi J, Kalsaria P, Danek B, Banerjee S, and Brilakis ES. Coronary artery spatial distribution of chronic total occlusions: Insights from a large US registry Catheter Cardiovasc Interv 2016;PMID: 27860111. Full Text

Gebhard C, Buechel RR, Stahli BE, Gransar H, Achenbach S, Berman DS, Budoff MJ, Callister TQ, Chow B, Dunning A, Al-Mallah MH, Cademartiri F, Chinnaiyan K, Rubinshtein R, Marques H, DeLago A, Villines TC, Hadamitzky M, Hausleiter J, Shaw LJ, Cury RC, Feuchtner G, Kim YJ, Maffei E, Raff G, Pontone G, Andreini D, Chang HJ, Leipsic J, Min JK, and Kaufmann PA. Impact of age and sex on left ventricular function determined by coronary computed tomographic angiography: results from the prospective multicentre CONFIRM study Eur Heart J Cardiovasc Imaging 2016;PMID: 27461207. Article Request Form

Greenbaum AB, Babaliaros VC, Chen MY, Stine AM, Rogers T, O'Neill WW, Paone G, Thourani VH, Muhammad KI, Leonardi RA, Ramee S, Troendle JF, and Lederman RJ. Transcaval access and closure for transcatheter aortic valve replacement: A prospective investigation J Am Coll Cardiol 2016;PMID: 27989885. Full text

Guerrero M, Dvir D, Himbert D, Urena M, Eleid M, Wang DD, Greenbaum A, Mahadevan VS, Holzhey D, O'Hair D, Dumonteil N, Rodes-Cabau J, Piazza N, Palma JH, DeLago A, Ferrari E, Witkowski A, Wendler O, Kornowski R, Martinez-Clark P, Ciaburri D, Shemin R, Alnasser S, McAllister D, Bena M, Kerendi F, Pavlides G, Sobrinho JJ, Attizzani GF, George I, Nickenig G, Fassa AA, Cribier A, Bapat V, Feldman T, Rihal C, Vahanian A, Webb J, and O'Neill W. Transcatheter mitral valve replacement in native mitral valve disease with severe mitral annular calcification: Results from the first multicenter global registry JACC Cardiovasc Interv 2016; 9(13):1361-1371. PMID: 27388824. Full Text

Guerrero M, Urena M, Pursnani A, Wang DD, Vahanian A, O'Neill W, Feldman T, and Himbert D. Balloon expandable transcatheter heart valves for native mitral valve disease with severe mitral annular calcification J Cardiovasc Surg (Torino) 2016; 57(3):401-409. PMID: 27094423. Full Text

Guerrero M, Wang DD, and O'Neill W. Percutaneous alcohol septal ablation to acutely reduce left ventricular outflow tract obstruction induced by transcatheter mitral valve replacement Catheter Cardiovasc Interv 2016; 88(6):E191- e197. PMID: 27377756. Full text

Handy CE, Desai CS, Dardari ZA, Al-Mallah MH, Miedema MD, Ouyang P, Budoff MJ, Blumenthal RS, Nasir K, and Blaha MJ. The association of coronary artery calcium with noncardiovascular disease: The multi-ethnic study of atherosclerosis JACC Cardiovasc Imaging 2016;PMID: 26970999. Full Text

Hencken L, To L, Ly N, and Morgan JA. Serotonin syndrome following methylene blue administration for vasoplegic syndrome J Card Surg 2016; 31(4):208-210. PMID: 26934199. Full Text

Hudson M. PCI with drug-eluting stents reduced revascularizations, but not mortality or MI,

52 compared with bare- metal stents Ann Intern Med 2016; 165(10):Jc52. PMID: 27842389. Full Text

Hung RK, Al-Mallah MH, Whelton SP, Michos ED, Blumenthal RS, Ehrman JK, Brawner CA, Keteyian SJ, and Blaha MJ. Effect of beta-blocker therapy, maximal heart rate, and exercise capacity during stress testing on long-term survival (from the henry ford exercise testing project) Am J Cardiol 2016;PMID: 27670797. Full Text

Jain T, Shah J, Shah S, and Modi S. Heart within a heart J Cardiovasc Ultrasound 2016; 24(1):60-63. PMID: 27081446. Full Text

Jain T, Nowak R, Hudson M, Frisoli T, Jacobsen G, and McCord J. Short- and long-term prognostic utility of the HEART score in patients evaluated in the emergency department for possible acute coronary syndrome Crit Pathw Cardiol 2016; 15(2):40-45. PMID: 27183252. Full Text

Kabbani L, Munie S, Lin J, Velez M, Isseh I, Brooks S, Leix S, and Shepard A. Flow patterns in the carotid arteries of patients with left ventricular assist devices Ann Vasc Surg 2016;PMID: 27531092. Full Text

Kabbani LS, Wasilenko S, Nypaver TJ, Weaver MR, Taylor AR, Abdul-Nour K, Borgi J, and Shepard AD. Socioeconomic disparities affect survival after aortic dissection J Vasc Surg 2016; 64(5):1239-1245. PMID: 27374067. Full Text

Karacsonyi J, Karatasakis A, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Wyman MR, Lombardi WL, Grantham JA, Kandzari DE, Lembo N, Moses JW, Kirtane AJ, Parikh MA, Green P, Finn M, Garcia S, Doing A, Patel M, Bahadorani J, Martinez Parachini JR, Resendes E, Rangan BV, Ungi I, Thompson CA, Banerjee S, and Brilakis ES. Effect of previous failure on subsequent procedural outcomes of chronic total occlusion percutaneous coronary intervention (from a Contemporary Multicenter Registry) Am J Cardiol 2016;PMID: 26899493. Full Text

Karacsonyi J, Alaswad K, Jaffer FA, Yeh RW, Patel M, Bahadorani J, Karatasakis A, Danek BA, Doing A, Grantham JA, Karmpaliotis D, Moses JW, Kirtane A, Parikh M, Ali Z, Lombardi WL, Kandzari DE, Lembo N, Garcia S, Wyman MR, Alame A, Nguyen-Trong PK, Resendes E, Kalsaria P, Rangan BV, Ungi I, Thompson CA, Banerjee S, and Brilakis ES. Use of intravascular imaging during chronic total occlusion percutaneous coronary intervention: Insights from a contemporary multicenter registry J Am Heart Assoc 2016; 5(8)PMID: 27543800. Full Text

Karacsonyi J, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel M, Bahadorani J, Doing A, Ali ZA, Karatasakis A, Danek BA, Rangan BV, Alame AJ, Banerjee S, and Brilakis ES. Prevalence, indications and management of balloon uncrossable chronic total occlusions: Insights from a contemporary multicenter US registry Catheter Cardiovasc Interv 2016;PMID: 27650935. Full Text

Karatasakis A, Tarar MN, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Wyman RM, Lombardi WL, Grantham JA, Kandzari DE, Lembo NJ, Moses JW, Kirtane AJ, Parikh M, Garcia S, Doing A, Pershad A, Shah A, Patel M, Bahadorani J, Shoultz CA, Jr., Danek BA, Thompson CA, Banerjee S, and Brilakis ES. Guidewire and microcatheter utilization patterns during antegrade wire escalation in chronic total occlusion percutaneous coronary intervention: Insights from a contemporary multicenter registry Catheter Cardiovasc Interv 2016;PMID: 27184465. Full Text

Karatasakis A, Danek BA, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel M, Bahadorani JN, Lombardi WL, Wyman RM, Grantham JA, Kandzari DE, Lembo NJ, Doing AH, Toma C, Moses JW, Kirtane AJ, Parikh MA, Ali ZA, Garcia S, Kalsaria P, Karacsonyi J, Alame AJ, Thompson CA, Banerjee S, and Brilakis ES. Comparison of various scores for predicting success of chronic total occlusion percutaneous coronary intervention Int J Cardiol 2016; 224:50-56. PMID: 27611917. Full Text

Karmpaliotis D, Karatasakis A, Alaswad K, Jaffer FA, Yeh RW, Wyman RM, Lombardi WL, Grantham JA, Kandzari DE, Lembo NJ, Doing A, Patel M, Bahadorani JN, Moses JW, Kirtane AJ, Parikh M, Ali ZA, Kalra S, Nguyen-Trong PK, Danek BA, Karacsonyi J, Rangan BV, Roesle MK, Thompson CA, Banerjee S, and Brilakis ES. Outcomes with the use of the retrograde approach for coronary chronic

53 total occlusion interventions in a contemporary multicenter US registry Circ Cardiovasc Interv 2016; 9(6)PMID: 27307562. Full Text

Kelly JP, Dunning A, Schulte PJ, Fiuzat M, Leifer ES, Fleg JL, Cooper LS, Keteyian SJ, Kitzman DW, Pina IL, Kraus WE, Whellan DJ, O'Connor CM, and Mentz RJ. Statins and exercise training response in heart failure patients: Insights from hf-action JACC Heart Fail 2016; 4(8):617-624. PMID: 27395348. Full Text

Keteyian SJ, and Kerrigan DJ. Tugging on a simpler test to evaluate physical mobility and function in patients with heart failure J Card Fail 2016;PMID: 26777756. Full Text

Keteyian SJ, Patel M, Kraus WE, Brawner CA, McConnell TR, Pina IL, Leifer ES, Fleg JL, Blackburn G, Fonarow GC, Chase PJ, Piner L, Vest M, O'Connor CM, Ehrman JK, Walsh MN, Ewald G, Bensimhon D, and Russell SD. Variables measured during cardiopulmonary exercise testing as predictors of mortality in chronic systolic heart failure J Am Coll Cardiol 2016; 67(7):780-789. PMID: 26892413. Full Text

Keteyian SJ, Kerrigan DJ, Ehrman JK, and Brawner CA. Exercise training workloads upon exit from cardiac rehabilitation in men and women: The henry ford hospital experience J Cardiopulm Rehabil Prev 2016;PMID: 27755258. Full Text

Khan JM, Rogers T, Schenke WH, Mazal JR, Faranesh AZ, Greenbaum AB, Babaliaros VC, Chen MY, and Lederman RJ. Intentional laceration of the anterior mitral valve leaflet to prevent left ventricular outflow tract obstruction during transcatheter mitral valve replacement: Pre- clinical findings JACC Cardiovasc Interv 2016; 9(17):1835-1843. PMID: 27609260. Full Text

Kim J, Al-Mallah M, Juraschek SP, Brawner C, Keteyian SJ, Nasir K, Dardari ZA, Blumenthal RS, and Blaha MJ. The association of clinical indication for exercise stress testing with all-cause mortality: the FIT Project Arch Med Sci 2016; 12(2):303-309. PMID: 27186173. Full Text

Kim J, Budoff MJ, Nasir K, Wong ND, Yeboah J, Al-Mallah MH, Shea S, Dardari ZA, Blumenthal RS, Blaha MJ, and Cainzos-Achirica M. Thoracic aortic calcium, cardiovascular disease events, and all- cause mortality in asymptomatic individuals with zero coronary calcium: The Multi-Ethnic Study of Atherosclerosis (MESA) Atherosclerosis 2016; 257:1-8. PMID: 28033543. Full text

Kirtane AJ, Doshi D, Leon MB, Lasala JM, Ohman EM, O'Neill WW, Shroff A, Cohen MG, Palacios IF, Beohar N, Uriel N, Kapur NK, Karmpaliotis D, Lombardi W, Dangas GD, Parikh MA, Stone GW, and Moses JW. Treatment of higher-risk patients with an indication for revascularization: Evolution within the field of contemporary percutaneous coronary intervention Circulation 2016; 134(5):422- 431. PMID: 27482004. Full Text

Krittanawong C, Namath A, Lanfear DE, and Tang WH. Practical pharmacogenomic approaches to heart failure therapeutics Curr Treat Options Cardiovasc Med 2016; 18(10):60. PMID: 27566707. Full Text

Kupsky DF, Alaswad K, and Rabbani BT. A rare case of aspergillus pericarditis with associated myocardial abscess and echocardiographic response to therapy Echocardiography 2016;PMID: 27009593. Full Text

Kutyifa V, Daubert JP, Schuger C, Goldenberg I, Klein H, Aktas MK, McNitt S, Stockburger M, Merkely B, Zareba W, and Moss AJ. Novel ICD Programming and Inappropriate ICD Therapy in CRT-D Versus ICD Patients: A MADIT-RIT Sub-Study Circ Arrhythm Electrophysiol 2016; 9(1)PMID: 26743237. Full Text

Likosky DS, Paugh TA, Harrington SD, Wu X, Rogers MA, Dickinson TA, DeLucia A, 3rd, Benedetti BR, Prager RL, Zhang M, and Paone G. Prediction of transfusions after isolated coronary artery bypass grafting surgical procedures Ann Thorac Surg 2016;PMID: 27726856. Full Text

Lindholm D, James SK, Bertilsson M, Becker RC, Cannon CP, Giannitsis E, Harrington RA, Himmelmann A, Kontny F, Siegbahn A, Steg PG, Storey RF, Velders MA, Weaver WD, and Wallentin L. Biomarkers and coronary lesions predict outcomes after revascularization in non-st-elevation acute 54 coronary syndrome Clin Chem 2016;PMID: 27932413. Full text

Luzum JA, and Lanfear DE. Pharmacogenetic risk scores for perindopril clinical and cost effectiveness in stable coronary artery disease: When are we ready to implement? J Am Heart Assoc 2016; 5(3):e003440. PMID: 27021567. Full Text

Marchlinski FE, Haffajee CI, Beshai JF, Dickfeld TM, Gonzalez MD, Hsia HH, Schuger CD, Beckman KJ, Bogun FM, Pollak SJ, and Bhandari AK. Long-term success of irrigated radiofrequency catheter ablation of sustained ventricular tachycardia: post-approval THERMOCOOL VT trial J Am Coll Cardiol 2016; 67(6):674-683. PMID: 26868693. Full Text

Mark DB, Federspiel JJ, Cowper PA, Anstrom KJ, Hoffmann U, Patel MR, Davidson-Ray L, Daniels MR, Cooper LS, Knight JD, Lee KL, Douglas PS, Bonow R, Anderson G, Bertoni A, Carr JJ, Min JK, Proschan M, Spertus JA, Ulrich CM, Al-Khalidi HR, Bonds D, Cook N, Dolor RJ, Go A, Fordyce C, Harding T, Hayden S, Kosinski A, Krucoff MW, Leifer E, Martinez B, Mudrick DW, Picard MH, Rubin G, Salvaggio K, Schneider RM, Shen A, Tardif JC, Tate W, Udelson JE, Vavalle J, Velazquez EJ, Garg J, Huang M, Wu S, Yang Q, Yow E, Zhang A, Apgar C, Achenbach S, Corsini E, Ghoshhajra BB, Lu M, Truong Q, Kinan D, Carlos E, Cole J, Johnson M, Krista M, Ridner M, Abidov A, Barker B, Bies R, Jones D, Weathers L, Albert T, Ariani K, Banerjee S, Budoff M, Chang D, Forman S, Foster G, Hsu J, Jang J, Kahn A, Karlsberg R, Krishnam M, Lee M, Lepor N, Loh I, Lurie M, McConnell M, Ruehm S, Vorobiof G, Abramson S, Friedrich S, Moloo J, Treat S, Keller A, Yang C, Bramlet D, Braun E, Foucauld J, Ghai A, Guzman P, Hendel R, Javier J, Schmalfuss C, Sotolongo C, Tannenbaum A, Weinstock B, Champney K, Frohwein S, Jenkins L, Koganti D, Litwin S, Shapiro P, Leung C, Hinchman D, Clark S, Danciu S, Hines J, Patel A, Sullivan D, Trivedi D, Vidovich M, Mahenthiran J, Shaikh S, Teague S, Clark C, Martin E, Sigurdsson G, Bloom S, Hagley M, Schmidt W, Sorrell V, Turner M, Weiss R, Hearne S, Jerome S, Morss A, Ruberg R, Abdul-Nour K, Chinnaiyan K, Goraya T, Heath J, Meengs M, Nahhas G, Nounou M, Saba S, Sallach S, Ginete W, Helmer G, McLaurin M, Pellikka P, Pelzel J, Carroll W, Martin A, Rivard A, Ciaramita J, Hawa Z, Woodard P, Jehle A, Delcore M, Porter T, Van De Graaff E, Budhwani N, Bullock-Palmer R, Espinoza A, Kostis J, Mustafa M, Cavanaugh B, Cohen R, Donnino R, Garcia M, Goodman D, Heitner J, Kamran M, Lader E, Marmulstein M, Menzies D, Morris R, Page B, Park C, Poon M, Wilson M, Atieh M, Bohle D, Dulin M, Gring C, Hakas J, McLean D, Rorie M, Sharkey K, Almanaseer Y, Dirkes W, Goldberg J, Iler M, Kutoloski K, Maaieh M, Mashny J, Pelberg R, Richards D, Tinkel J, Chrysant G, Des Prez R, Hill G, Hussain I, Shapiro M, Allen C, Babayan Z, Bauch T, Berliner J, Bove A, Fox D, Jacob R, Jamis-Dow C, Nadar V, Phiambolis T, Gregg D, Isbell D, Johnson S, Kumar P, Hiremagalur S, Huneycutt D, Korban E, Severance H, Banerjee S, Baweja G, Erwin J, Gigliotti O, Khan M, Lieber I, Navetta F, Osborne J, Slim A, Wilks R, George A, Hartman A, Levitt R, Phillips C, Salerno M, Schietinger B, Slowikowski J, Malhotra V, Waggoner LD, Carter W, Liberman J, Logemann T, Manley J, Port S, Zasadil M, Chow B, and Larose E. Economic outcomes with anatomical versus functional diagnostic testing for coronary artery disease Ann Intern Med 2016; 165(2):94-102. PMID: 27214597. Full Text

Martinez-Parachini JR, Karatasakis A, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel M, Bahadorani J, Doing A, Nguyen-Trong PK, Danek BA, Karacsonyi J, Alame A, Rangan BV, Thompson CA, Banerjee S, and Brilakis ES. Impact of diabetes mellitus on acute outcomes of percutaneous coronary intervention in chronic total occlusions: insights from a US multicentre registry Diabet Med 2016;PMID: 27743404. Full Text

Mawri S, Michaels A, Gibbs J, Shah S, Rao S, Kugelmass A, Lingam N, Arida M, Jacobsen G, Rowlandson I, Iyer K, Khandelwal A, and McCord J. The comparison of physician to computer interpreted electrocardiograms on ST-elevation myocardial infarction door-to-balloon times Crit Pathw Cardiol 2016; 15(1):22-25. PMID: 26881816. Full Text

McAuley PA, Blaha MJ, Keteyian SJ, Brawner CA, Al Rifai M, Dardari ZA, Ehrman JK, and Al- Mallah MH. Fitness, fatness, and mortality: The FIT (henry ford exercise testing) project Am J Med 2016;PMID: 27154778. Full Text

McDonagh JR, Seth M, LaLonde TA, Khandelwal AK, Wohns DH, Dixon SR, and Gurm HS. Radial pci and the obesity paradox: Insights from blue cross blue shield of michigan cardiovascular consortium (bmc2) Catheter Cardiovasc Interv 2016; 87(2):211-219. PMID: 26010906. Full Text

55 Meredith IT, Tanguay JF, Kereiakes DJ, Cutlip DE, Yeh RW, Garratt KN, Lee DP, Steg PG, Weaver WD, Holmes DR, Jr., Brindis RG, Trebacz J, Massaro JM, Hsieh WH, and Mauri L. Diabetes mellitus and prevention of late myocardial infarction after coronary stenting in the randomized dual antiplatelet therapy study Circulation 2016;PMID: 26994121. Full Text

Morgan JA, and O'Neill WW. Percutaneous right ventricular assist device support in a patient supported by an LVAD Asaio j 2016;PMID: 26771398. Full Text

Morgan JA, Go PH, Xuereb L, Kaur B, Akrawe S, Nemeh HW, Borgi J, Lanfear DE, Williams CT, and Paone G. Outcomes on continuous flow left ventricular assist devices: A single institutional 9-year experience Ann Thorac Surg 2016;PMID: 27173072. Full Text

Mueller C, Giannitsis E, Christ M, Ordonez-Llanos J, deFilippi C, McCord J, Body R, Panteghini M, Jernberg T, Plebani M, Verschuren F, French J, Christenson R, Weiser S, Bendig G, Dilba P, and Lindahl B. Multicenter evaluation of a 0-hour/1-hour algorithm in the diagnosis of myocardial infarction with high-sensitivity cardiac troponin t Ann Emerg Med 2016;PMID: 26794254. Full Text

Mueller-Hennessen M, Lindahl B, Giannitsis E, Biener M, Vafaie M, deFilippi CR, Christ M, Santalo- Bel M, Panteghini M, Plebani M, Verschuren F, Jernberg T, French JK, Christenson RH, Body R, McCord J, Dilba P, Katus HA, and Mueller C. Diagnostic and prognostic implications using age- and gender- specific cut-offs for high-sensitivity cardiac troponin T - Sub-analysis from the TRAPID-AMI study Int J Cardiol 2016; 209:26-33. PMID: 26878470. Full Text

Mueller-Hennessen M, Mueller C, Giannitsis E, Biener M, Vafaie M, deFilippi CR, Christ M, Ordonez- Llanos J, Panteghini M, Plebani M, Verschuren F, Melki D, French JK, Christenson RH, Body R, McCord J, Dinkel C, Katus HA, and Lindahl B. Serial sampling of high-sensitivity cardiac troponin t may not be required for prediction of acute myocardial infarction diagnosis in chest pain patients with highly abnormal concentrations at presentation Clin Chem 2016;PMID: 27932414. Full text

Nguyen-Trong PK, Alaswad K, Karmpaliotis D, Lombardi W, Grantham JA, Lembo N, Kandzari D, Karatasakis A, Karacsonyi J, Danek BA, Rangan BV, Roesle M, Ayers CR, Thompson CA, Banerjee S, and Brilakis ES. Use of saphenous vein bypass grafts for retrograde recanalization of coronary chronic total occlusions: Insights from a multicenter registry J Invasive Cardiol 2016; 28(6):218-224. PMID: 27236005. Full Text

O'Neill BP, Wheatley G, Bashir R, Edmundowicz D, O'Murchu B, O'Neill WW, Patil P, Chen A, Forfia P, and Cohen HA. Study design and rationale of the heterotopic implantation of the Edwards- Sapien XT transcatheter valve in the inferior VEna cava for the treatment of severe tricuspid regurgitation (HOVER) trial Catheter Cardiovasc Interv 2016;PMID: 27122473. Full Text

O'Neill BP, and O'Neill WW. Tricuspid valve intervention: New direction and new hope J Am Coll Cardiol 2016; 68(10):1034-1036. PMID: 27585508. Full Text

Parikh KS, Coles A, Schulte PJ, Kraus WE, Fleg JL, Keteyian SJ, Pina IL, Fiuzat M, Whellan DJ, O'Connor CM, and Mentz RJ. Relation of angina pectoris to outcomes, quality of life, and response to exercise training in patients with chronic heart failure (from HF-ACTION) Am J Cardiol 2016;PMID: 27561194. Full Text

Reddy VY, Gibson DN, Kar S, O'Neill W, Doshi SK, Horton RP, Buchbinder M, Gordon NT, and Holmes DR. Post- FDA Approval, Initial US clinical experience with watchman left atrial appendage closure for stroke prevention in atrial fibrillation J Am Coll Cardiol 2016;PMID: 27816552. Full Text

Shafiq A, Brawner CA, Aldred HA, Lewis B, Williams CT, Tita C, Schairer JR, Ehrman JK, Velez M, Selektor Y, Lanfear DE, and Keteyian SJ. Prognostic value of cardiopulmonary exercise testing in heart failure with preserved ejection fraction. The Henry Ford HospITal CardioPulmonary EXercise Testing (FIT-CPX) project Am Heart J 2016; 174:167-172. PMID: 26995385. Full Text

56 Shah J, Jain T, Shah S, Mawri S, and Ananthasubramaniam K. Rare case of unileaflet mitral valve J Cardiovasc Ultrasound 2016; 24(2):168-169. PMID: 27358711. Full Text

Shavelle DM, Kirtane AJ, Schreiber TL, Kapasi NK, O'Neill WW, Moses JW, Popma J, and Matthews RV. Impact of surgical consultation on outcomes in hemodynamically supported high-risk percutaneous coronary intervention: Insights from protect ii randomized study J Invasive Cardiol 2016; 28(5):187-192. PMID: 26887029. Full Text

Shaya GE, Al-Mallah MH, Hung RK, Nasir K, Blumenthal RS, Ehrman JK, Keteyian SJ, Brawner CA, Qureshi WT, and Blaha MJ. High Exercise Capacity Attenuates the Risk of Early Mortality After a First Myocardial Infarction: The Henry Ford Exercise Testing (FIT) Project Mayo Clin Proc 2016; 91(2):129-139. PMID: 26848000. Full Text

Singh V, Damluji AA, Mendirichaga R, Alfonso CE, Martinez CA, Williams D, Heldman AW, de Marchena EJ, O'Neill WW, and Cohen MG. Elective or emergency use of mechanical circulatory support devices during transcatheter aortic valve replacement J Interv Cardiol 2016;PMID: 27550213. Full Text

Singh V, Rodriguez AP, Thakkar B, Patel NJ, Ghatak A, Badheka AO, Alfonso CE, de Marchena E, Sakhuja R, Inglessis-Azuaje I, Palacios I, Cohen MG, Elmariah S, and O'Neill WW. Comparison of outcomes of transcatheter aortic valve replacement plus percutaneous coronary intervention versus transcatheter aortic valve replacement alone in the United States Am J Cardiol 2016;PMID: 27665205. Full Text

Sivanandam A, and Ananthasubramaniam K. Midventricular hypertrophic cardiomyopathy with apical aneurysm: Potential for underdiagnosis and value of multimodality imaging Case Rep Cardiol 2016; 2016:9717948. PMID: 26904306. Full Text

Sleder A, Tackett S, Cerasale M, Mittal C, Isseh I, Radjef R, Taylor A, Farha R, Lupak O, Larkin D, Lamerato L, Divine G, Wisdom K, Baker-Genaw K, and O'Neill W. Socioeconomic and racial disparities: A case-control study of patients receiving transcatheter aortic valve replacement for severe aortic stenosis J Racial Ethn Health Disparities 2016;PMID: 28039604. Article Request Form

Srivastava AV, and Ananthasubramaniam K. Guiding coronary revascularization using PET stress myocardial perfusion imaging: The proof is in the pudding J Nucl Cardiol 2016;PMID: 27033351. Article Request Form

Vavalle JP, van Diepen S, Clare RM, Hochman JS, Weaver WD, Mehta RH, Pieper KS, Patel MR, Patel UD, Armstrong PW, Granger CB, and Lopes RD. Renal failure in patients with ST-segment elevation acute myocardial infarction treated with primary percutaneous coronary intervention: Predictors, clinical and angiographic features, and outcomes Am Heart J 2016; 173:57-66. PMID: 26920597. Full Text

Verma S, Burkhoff D, and O'Neill WW. Avoiding hemodynamic collapse during high-risk percutaneous coronary intervention: Advanced hemodynamics of impella support Catheter Cardiovasc Interv 2016;PMID: 27658747. Full Text

Verma AK, Schulte PJ, Bittner V, Keteyian SJ, Fleg JL, Pina IL, Swank AM, Fitz-Gerald M, Ellis SJ, Kraus WE, Whellan DJ, O'Connor CM, and Mentz RJ. Socioeconomic and partner status in chronic heart failure: Relationship to exercise capacity, quality of life, and clinical outcomes Am Heart J 2017; 183:54-61. PMID: 27979042. Full text

Wallentin L, Held C, Armstrong PW, Cannon CP, Davies RY, Granger CB, Hagstrom E, Harrington RA, Hochman JS, Koenig W, Krug-Gourley S, Mohler ER, 3rd, Siegbahn A, Tarka E, Steg PG, Stewart RA, Weiss R, Ostlund O, Weaver WD, and White HD. Lipoprotein-associated phospholipase a2 activity is a marker of risk but not a useful target for treatment in patients with stable coronary heart disease J Am Heart Assoc 2016; 5(6)PMID: 27329448. Full Text

Wang DD, Eng M, Greenbaum A, Myers E, Forbes M, Pantelic M, Song T, Nelson C, Divine G, Taylor A, Wyman J, Guerrero M, Lederman RJ, Paone G, and O'Neill W. Predicting LVOT

57 Obstruction After TMVR JACC Cardiovasc Imaging 2016;PMID: 27209112. Full Text

Wang DD, Eng M, Kupsky D, Myers E, Forbes M, Rahman M, Zaidan M, Parikh S, Wyman J, Pantelic M, Song T, Nadig J, Karabon P, Greenbaum A, and O'Neill W. Application of 3- dimensional computed tomographic image guidance to WATCHMAN implantation and impact on early operator learning curve: Single-center experience JACC Cardiovasc Interv 2016; 9(22):2329-2340. PMID: 27884358. Full Text

Yadav PK, and Eng MH. Size does matter but is there an obesity paradox in TAVR? Catheter Cardiovasc Interv 2016; 88(1):125-126. PMID: 27400640. Full Text

Yadav PK, and Eng MH. A toast to no sternotomy Catheter Cardiovasc Interv 2016; 88(6):960-961. PMID: 27886454. Full Text

Cardiology / Cardiovascular Research

Adams KF, Jr., Butler J, Patterson JH, Gattis Stough W, Bauman JL, van Veldhuisen DJ, Schwartz TA, Sabbah H, Mackowiak JI, Ventura HO, and Ghali JK. Dose response characterization of the association of serum digoxin concentration with mortality outcomes in the Digitalis Investigation Group trial Eur J Heart Fail 2016; 18(8):1072- 1081. PMID: 27492641. Full Text

Ardell JL, Andresen MC, Armour JA, Billman GE, Chen PS, Foreman RD, Herring N, O'Leary DS, Sabbah HN, Schultz HD, Sunagawa K, and Zucker IH. Translational Neurocardiology: preclinical models and cardioneural integrative aspects J Physiol 2016;PMID: 27098459. Full Text

Brown DA, Perry JB, Allen ME, Sabbah HN, Stauffer BL, Shaikh SR, Cleland JG, Colucci WS, Butler J, Voors AA, Anker SD, Pitt B, Pieske B, Filippatos G, Greene SJ, and Gheorghiade M. Expert consensus document: Mitochondrial function as a therapeutic target in heart failure Nat Rev Cardiol 2016;PMID: 28004807. Article Request Form

Dinh W, Albrecht-Kupper B, Gheorghiade M, Voors AA, van der Laan M, and Sabbah HN. Partial adenosine a1 agonist in heart failure Handb Exp Pharmacol 2016;PMID: 27770217. Article request form

Eirin A, Ebrahimi B, Kwon SH, Fiala JA, Williams BJ, Woollard JR, He Q, Gupta RC, Sabbah HN, Prakash YS, Textor SC, Lerman A, and Lerman LO. Restoration of mitochondrial cardiolipin attenuates cardiac damage in swine renovascular hypertension J Am Heart Assoc 2016; 5(6)PMID: 27247333. Full Text

Gheorghiade M, Larson CJ, Shah SJ, Greene SJ, Cleland JG, Colucci WS, Dunnmon P, Epstein SE, Kim RJ, Parsey RV, Stockbridge N, Carr J, Dinh W, Krahn T, Kramer F, Wahlander K, Deckelbaum LI, Crandall D, Okada S, Senni M, Sikora S, Sabbah HN, and Butler J. Developing new treatments for heart failure: Focus on the heart Circ Heart Fail 2016; 9(5)PMID: 27166246. Full Text

Greene SJ, Sabbah HN, Butler J, Voors AA, Albrecht-Kupper BE, Dungen HD, Dinh W, and Gheorghiade M. Partial adenosine A1 receptor agonism: a potential new therapeutic strategy for heart failure Heart Fail Rev 2016; 21(1):95-102. PMID: 26701329. Full Text

Sabbah HN, Gupta RC, Kohli S, Wang M, Hachem S, and Zhang K. Chronic Therapy With Elamipretide (MTP-131), a Novel Mitochondria-Targeting Peptide, Improves Left Ventricular and Mitochondrial Function in Dogs With Advanced Heart Failure Circ Heart Fail 2016; 9(2):e002206. PMID: 26839394. Full Text

Sabbah HN. Targeting mitochondrial dysfunction in the treatment of heart failure Expert Rev Cardiovasc Ther 2016;PMID: 27758146. Article request form

Sabbah HN. Silent disease progression in clinically stable heart failure Eur J Heart Fail 2016;PMID: 27976514. Full text

58 Endocrinology and Metabolism

Bossick AS, Peters RM, Burmeister C, Kakumanu N, Shill JE, and Cassidy-Bushrow AE. Antenatal inflammation and gestational diabetes mellitus risk among pregnant African-American women J Reprod Immunol 2016; 115:1-5. PMID: 27061480. Full Text

Brunton SA, Kruger DF, and Funnell MM. Role of emerging insulin technologies in the initiation and intensification of insulin therapy for diabetes in primary care Clin Diabetes 2016; 34(1):34-43. PMID: 26807007. Article Request Form

Dempster DW, Zhou H, Recker RR, Brown JP, Recknor CP, Lewiecki EM, Miller PD, Rao SD, Kendler DL, Lindsay R, Krege JH, Alam J, Taylor KA, Janos B, and Ruff VA. Differential effects of teriparatide and denosumab on intact PTH and bone formation indices: AVA osteoporosis study J Clin Endocrinol Metab 2016:jc20154181. PMID: 26859106. Full Text

Gomez-Sanchez CE, Qi X, Gomez-Sanchez EP, Sasano H, Bohlen MO, and Wisgerhof M. Disordered zonal and cellular CYP11B2 enzyme expression in familial hyperaldosteronism type 3 Mol Cell Endocrinol 2016;PMID: 27793677. Article request form

He F, Zhang W, Shen Y, Yu P, Bao Q, Wen J, Hu C, and Qiu S. Effects of resection margins on local recurrence of osteosarcoma in extremity and pelvis: Systematic review and meta-analysis Int J Surg 2016; 36(Pt A):283-292. PMID: 27840310. Full Text

Khan AA, Hanley DA, Rizzoli R, Bollerslev J, Young JE, Rejnmark L, Thakker R, D'Amour P, Paul T, Van Uum S, Shrayyef MZ, Goltzman D, Kaiser S, Cusano NE, Bouillon R, Mosekilde L, Kung AW, Rao SD, Bhadada SK, Clarke BL, Liu J, Duh Q, Lewiecki EM, Bandeira F, Eastell R, Marcocci C, Silverberg SJ, Udelsman R, Davison KS, Potts JT, Jr., Brandi ML, and Bilezikian JP. Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus Osteoporos Int 2016;PMID: 27613721. Full Text

Kruger DF. A toast to our history Clin Diabetes 2016; 34(4):171-172. PMID: 27766007. Article request form

Kulkarni P, Cushman T, Donthireddy V, and Rao S. Spontaneously recovered severe thrombocytopaenia following zoledronic acid infusion for osteoporosis BMJ Case Rep 2016; 2016PMID: 26843222. Full Text

Kulkarni P, Lahiri SW, and Rao SD. Letter to the editor: Effect of parathyroidectomy on renal function: Dichotomous results and confusing conclusions J Clin Endocrinol Metab 2016; 101(2):L9. PMID: 26840121. Full Text

Lahiri SW. Management of type 2 diabetes in the setting of morbid obesity: How can weight gain be prevented or reversed? Clin Diabetes 2016; 34(2):115-120. PMID: 27092024. Article Request Form

Petraszko A, Siegal D, Flynn M, Rao SD, Peterson E, and van Holsbeeck M. The advantages of tomosynthesis for evaluating bisphosphonate-related atypical femur fractures compared to radiography Skeletal Radiol 2016;PMID: 26861160. Full Text

Petraszko A, Siegal D, Flynn M, Rao SD, Peterson E, and van Holsbeeck M. Erratum to: The advantages of tomosynthesis for evaluating bisphosphonate-related atypical femur fractures compared to radiography Skeletal Radiol 2016;PMID: 26899141. Full Text

Putnam R, Dhibar DP, Varshney S, Behera A, Mittal BR, Bhansali A, Rao SD, and Bhadada SK. Effect of curative parathyroidectomy on insulin resistance Indian J Endocrinol Metab 2016; 20(6):784- 789. PMID: 27867880. Full Text

Qiu S, Divine GW, Palnitkar S, Kulkarni P, Guthrie TS, Honasoge M, and Rao SD. Bone structure and turnover status in postmenopausal women with atypical femur fracture after prolonged bisphosphonate therapy Calcif Tissue Int 2016;PMID: 28013363. Full text

59 Gastroenterology

Brady JE, Liffmann DK, Yartel A, Kil N, Federman AD, Kannry J, Jordan C, Massoud OI, Nerenz DR, Brown KA, Smith BD, Vellozzi C, and Rein DB. Uptake of hepatitis c screening, characteristics of patients tested, and intervention costs in the BEST-C study Hepatology 2016;PMID: 27770543. Full Text

Buti M, Gordon SC, Zuckerman E, Lawitz E, Calleja JL, Hofer H, Gilbert C, Palcza J, Howe AY, DiNubile MJ, Robertson MN, Wahl J, Barr E, and Forns X. Grazoprevir, Elbasvir, and Ribavirin for Chronic Hepatitis C Virus Genotype 1 Infection After Failure of Pegylated Interferon and Ribavirin With an Earlier-Generation Protease Inhibitor: Final 24-Week Results From C-SALVAGE Clin Infect Dis 2016; 62(1):32-36. PMID: 26371152. Full Text

Elmunzer BJ, and Piraka CR. EUS-guided methylene blue injection to facilitate pancreatic duct access after unsuccessful ERCP Gastroenterology 2016;PMID: 27639800. Full Text

Fischer M, Kao D, Kelly C, Kuchipudi A, Jafri SM, Blumenkehl M, Rex D, Mellow M, Kaur N, Sokol H, Cook G, Hamilton MJ, Phelps E, Sipe B, Xu H, and Allegretti JR. Fecal microbiota transplantation is safe and efficacious for recurrent or refractory clostridium difficile infection in patients with inflammatory bowel disease Inflamm Bowel Dis 2016; 22(10):2402-2409. PMID: 27580384. Full Text

Foster MA, Xing J, Moorman AC, Boscarino J, Gordon SC, Lu M, Rupp L, Schmidt MA, Trinacty CM, Xu F, Holmberg SD, and Spradling PR. Frequency of and factors associated with receipt of liver- related specialty care among patients with hepatitis c in the chronic hepatitis cohort study Dig Dis Sci 2016;PMID: 27510752. Full Text

Gane E, Kowdley KV, Pound D, Stedman CA, Davis M, Etzkorn K, Gordon SC, Bernstein D, Everson G, Rodriguez- Torres M, Tsai N, Khalid O, Yang JC, Lu S, Dvory-Sobol H, Stamm LM, Brainard DM, McHutchison JG, Tong M, Chung RT, Beavers K, Poulos JE, Kwo PY, and Nguyen MH. Efficacy of Sofosbuvir, Velpatasvir, and GS-9857 in Patients with HCV Genotype 2, 3, 4, or 6 Infections in an Open-label, Phase 2 Trial Gastroenterology 2016;PMID: 27486033. Full Text

Gonzalez HC, Jafri SM, and Gordon SC. Management of acute hepatotoxicity including medical agents and liver support systems Clin Liver Dis 2017; 21(1):163-180. PMID: 27842770. Full Text

Jinjuvadia C, Jinjuvadia R, Mandapakala C, Durairajan N, Liangpunsakul S, and Soubani AO. Trends in outcomes, financial burden, and mortality for acute exacerbation of chronic obstructive pulmonary disease (copd) in the united states from 2002 to 2010 Copd 2016:1-8. PMID: 27419254. Article Request Form

Jinjuvadia R, Antaki F, Lohia P, and Liangpunsakul S. The association between nonalcoholic fatty liver disease and metabolic abnormalities in the United States population J Clin Gastroenterol 2016;PMID: 27580477. Full Text

Kruger DL, Rein DB, Kil N, Jordan C, Brown KA, Yartel A, and Smith BD. Implementation of birth- cohort testing for hepatitis c virus: Lessons learned from three primary care sites Health Promot Pract 2016;PMID: 27496859. Full Text

Lenhart A, Fernandez-Castillo J, Mullins K, and Salgia R. A rare case of gastric variceal hemorrhage secondary to infiltrative b-cell lymphoma Case Rep Gastroenterol 2016; 10(3):518- 524. PMID: 27843428. Full Text

Levitsky J, Verna EC, O'Leary JG, Bzowej NH, Moonka DK, Hyland RH, Arterburn S, Dvory-Sobol H, Brainard DM, McHutchison JG, and Terrault NA. Perioperative ledipasvir-sofosbuvir for HCV in liver- transplant recipients N Engl J Med 2016; 375(21):2106-2108. PMID: 27959735. Full text

60 Li J, Gordon SC, Rupp LB, Zhang T, Trudeau S, Holmberg SD, Moorman AC, Spradling PR, Teshale EH, Boscarino JA, Daida YG, Schmidt MA, and Lu M. Long-term progression of viral load and serum markers of fibrosis among treated and untreated patients with chronic hepatitis B J Gastroenterol Hepatol 2016;PMID: 27888529. Full Text

Lok AS, Pan CQ, Han SB, Trinh HN, Fessel WJ, Rodell T, Massetto B, Lin L, Gaggar A, Subramanian GM, McHutchison JG, Ferrari C, Lee H, Gordon SC, and Gane EJ. Randomized phase II study of GS- 4774 as a therapeutic vaccine in virally suppressed patients with chronic hepatitis B J Hepatol 2016;PMID: 27210427. Full Text

Lu M, Li J, Rupp LB, Holmberg SD, Moorman AC, Spradling PR, Teshale EH, Zhou Y, Boscarino JA, Schmidt MA, Lamerato LE, Trinacty C, Trudeau S, and Gordon SC. Hepatitis C treatment failure is associated with increased risk of hepatocellular carcinoma J Viral Hepat 2016;PMID: 27028626. Full Text

Lu M, Li J, Zhang T, Rupp LB, Trudeau S, Holmberg SD, Moorman AC, Spradling PR, Teshale EH, Xu F, Boscarino JA, Schmidt MA, Vijayadeva V, and Gordon SC. Long-term reduction in liver fibrosis, based on serum biomarkers, in patients with sustained viral responses to HCV treatment Clin Gastroenterol Hepatol 2016;PMID: 26804385. Full Text

Meighani A, Jafri SM, Raoufi M, and Salgia R. Splenic artery embolization for treatment of refractory ascites after liver transplantation ACG Case Rep J 2016; 3(2):136-138. PMID: 26958571. Full Text

Moorman AC, Tong X, Spradling PR, Rupp LB, Gordon SC, Lu M, Teshale EH, Boscarino JA, Trinacty CM, Schmidt MA, Xu F, and Holmberg SD. Prevalence of renal impairment and associated conditions among hcv-infected persons in the chronic hepatitis cohort study (CHeCS) Dig Dis Sci 2016;PMID: 27216163. Full Text

O'Leary JG, Fontana RJ, Brown K, Burton JR, Jr., Firpi-Morell R, Muir A, O'Brien C, Rabinovitz M, Reddy KR, Ryan R, Shprecher A, Villadiego S, Prabhakar A, and Brown RS, Jr. Efficacy and safety of simeprevir and sofosbuvir with and without ribavirin in subjects with recurrent genotype 1 hepatitis c post-orthotopic liver transplant: The randomized galaxy study Transpl Int 2016;PMID: 27896858. Full Text

Parekh R, Kazimi M, Skorupski S, Fagoaga O, Jafri S, and Segovia MC. Intestine transplantation across a positive crossmatch with preformed donor-specific antibodies Transplant Proc 2016; 48(2):489-491. PMID: 27109984. Full Text

Rao B, Jafri SM, Kazimi M, Mullins K, Raoufi M, and Segovia MC. A case report of acute cellular rejection following intestinal transplantation managed with adalimumab Transplant Proc 2016; 48(2):536-538. PMID: 27109995. Full Text

Rao B, Segovia MC, Kazimi M, Parekh R, Raoufi M, and Jafri SM. Use of everolimus after multivisceral transplantation: A report of two cases Transplant Proc 2016; 48(2):485-488. PMID: 27109983. Full Text

Spradling PR, Xing J, Rupp LB, Moorman AC, Gordon SC, Teshale ET, Lu M, Boscarino JA, Schmidt MA, Trinacty CM, and Holmberg SD. Distribution of disease phase, treatment prescription and severe liver disease among 1598 patients with chronic hepatitis B in the Chronic Hepatitis Cohort Study, 2006- 2013 Aliment Pharmacol Ther 2016;PMID: 27640985. Full Text

Sulejmani N, Jafri SM, and Gordon SC. Pharmacodynamics and pharmacokinetics of elbasvir and grazoprevir in the treatment of hepatitis C Expert Opin Drug Metab Toxicol 2016;PMID: 26849059. Article Request Form

61 Teshale EH, Xing J, Moorman A, Holmberg SD, Spradling PR, Gordon SC, Rupp LB, Lu M, Boscarino JA, Trinacity CM, Schmidt MA, and Xu F. Higher all-cause hospitalization among patients with chronic hepatitis C: the Chronic Hepatitis Cohort Study (CHeCS), 2006-2013 J Viral Hepat 2016;PMID: 27186944. Full Text

Xu F, Moorman AC, Tong X, Gordon SC, Rupp LB, Lu M, Teshale EH, Spradling PR, Boscarino JA, Trinacty CM, Schmidt MA, and Holmberg SD. All-cause mortality and progression risks to hepatic decompensation and hepatocellular carcinoma in patients infected with hepatitis c virus Clin Infect Dis 2016; 62(3):289-297. PMID: 26417034. Full Text

Younossi ZM, Park H, Gordon SC, Ferguson JR, Ahmed A, Dieterich D, and Saab S. Real-world outcomes of ledipasvir/sofosbuvir in treatment-naive patients with hepatitis C Am J Manag Care 2016; 22(6 Spec No.):Sp205-211. PMID: 27266950. Full Text

Younossi ZM, Park H, Dieterich D, Saab S, Ahmed A, and Gordon SC. The value of cure associated with treating treatment-naive chronic hepatitis C genotype 1: Are the new all-oral regimens good value to society? Liver Int 2016;PMID: 27804195. Full Text

62 Hematology-Oncology

Afifi S, Michael A, and Lesokhin A. Immunotherapy: A new approach to treating multiple myeloma Ann Pharmacother 2016;PMID: 27083916. Full Text

Alkhatib Y, Albashaireh D, Al-Aqtash T, and Awdish R. The role of tyrosine kinase inhibitor "Lapatinib" in pulmonary hypertension Pulm Pharmacol Ther 2016; 37:81-84. PMID: 26965087. Full Text

Alkhatib Y, and Guo Y. Lymphadenopathy in a patient with chronic myeloid leukaemia Br J Haematol 2016;PMID: 27174048. Full Text

Alkhatib Y, Abdel Rahman Z, and Kuriakose P. Clinical impact of metformin in diabetic diffuse large B-cell lymphoma patients: a case-control study Leuk Lymphoma 2016:1-5. PMID: 27701994. Article request form

Bertin MJ, Demirkiran O, Navarro G, Moss NA, Lee J, Goldgof GM, Vigil E, Winzeler EA, Valeriote FA, and Gerwick WH. Kalkipyrone B, a marine cyanobacterial gamma-pyrone possessing cytotoxic and anti- fungal activities Phytochemistry 2016; 122:113-118. PMID: 26632528. Article Request Form

Chow LQ, Smith DC, Tan AR, Denlinger CS, Wang D, Shepard DR, Chaudhary A, Lin Y, and Gao L. Lack of pharmacokinetic drug-drug interaction between ramucirumab and paclitaxel in a phase II study of patients with advanced malignant solid tumors Cancer Chemother Pharmacol 2016; 78(2):433-441. PMID: 27379498. Full Text

Farhan S, Peres E, and Janakiraman N. Choice of unmanipulated t cell replete graft for haploidentical stem cell transplant and posttransplant cyclophosphamide in hematologic malignancies in adults: Peripheral blood or bone marrow-review of published literature Adv Hematol 2016; 2016:6950346. PMID: 27118973. Full Text

Gulati R, Alkhatib Y, Donthireddy V, Felicella MM, Menon MP, and Inamdar KV. Isolated ocular manifestation of relapsed chronic myelogenous leukemia presenting as myeloid blast crisis in a patient on imatinib therapy: A case report and review of the literature Case Rep Pathol 2015; 2015:380451. PMID: 26819793. Full Text

Hamel LM, Penner LA, Eggly S, Chapman R, Klamerus JF, Simon MS, Stanton SC, and Albrecht TL. Do patients and oncologists discuss the cost of cancer treatment? An observational study of clinical interactions between african american patients and their oncologists J Oncol Pract 2016:Jop2016015859. PMID: 27960067. Article Request Form

Henry NL, Braun TM, Ali HY, Munir K, Silver SM, Gorski DH, Breslin TM, and Griggs JJ. Associations between use of the 21-gene recurrence score assay and chemotherapy regimen selection in a statewide registry Cancer 2016;PMID: 27787892. Full Text

Hung J, Taylor AR, Divine GW, Hafron JM, and Hwang C. The effect of time to castration resistance on outcomes with abiraterone and enzalutamide in metastatic prostate cancer Clin Genitourin Cancer 2016;PMID: 27157640. Full Text

Hwang C, Sethi S, Heilbrun LK, Gupta NS, Chitale DA, Sakr WA, Menon M, Peabody JO, Smith DW, Sarkar FH, and Heath EI. Anti-androgenic activity of absorption-enhanced 3, 3'-diindolylmethane in prostatectomy patients Am J Transl Res 2016; 8(1):166-176. PMID: 27069550. Full Text

Ibrahim RB, Skewes MD, and Kuriakose P. 'Sailing in troubled waters': a review of the use of anticoagulation in adult cancer patients with thrombocytopenia Blood Coagul Fibrinolysis 2016;PMID: 26945262. Full Text

Kahlon P, Nabi S, Arshad A, Jabbar A, and Haythem A. Warfarin dosing and time required to reach therapeutic international normalized ratio in patients with hypercoagulable conditions Turk J Haematol 2016; 33(4):299-303. PMID: 27093959. Full text

Kulkarni P, Cushman T, Donthireddy V, and Rao S. Spontaneously recovered severe thrombocytopaenia following zoledronic acid infusion for osteoporosis BMJ Case Rep 2016; 2016PMID: 63 26843222. Full Text

Kumar N, Nakagawa P, Janic B, Romero CA, Worou ME, Monu SR, Peterson EL, Shaw J, Valeriote F, Ongeri EM, Niyitegeka JV, Rhaleb NE, and Carretero OA. The anti-inflammatory peptide Ac-SDKP is released from thymosin beta4 by renal meprin alpha and prolyl oligopeptidase Am J Physiol Renal Physiol 2016:ajprenal.00562.02015. PMID: 26962108. Full Text

Modi D, Hwang C, Mamdani H, Kim S, Gayar H, Vaishampayan U, Joyrich R, and Heath EI. Radium- 223 in heavily pretreated metastatic castrate-resistant prostate cancer Clin Genitourin Cancer 2016;PMID: 27053499. Full Text

Nabi S, Kahlon P, and Kuriakose P. Analyzing multiple risk factors in patients with sarcomas. A case- control study Indian J Cancer 2015; 52(3):337-342. PMID: 26905132. Full Text

Nabi S, Kahlon P, Bozorgnia F, Arshad A, Saleem A, and Kuriakose P. Analyzing relationship between monoclonal gammopathy of undetermined significance (MGUS) with different types of neuropathy: An observational study Indian J Hematol Blood Transfus 2016; 32(2):186-192. PMID: 27065581. Full Text

Penner LA, Dovidio JF, Gonzalez R, Albrecht TL, Chapman R, Foster T, Harper FW, Hagiwara N, Hamel LM, Shields AF, Gadgeel S, Simon MS, Griggs JJ, and Eggly S. The effects of oncologist implicit racial bias in racially discordant oncology interactions J Clin Oncol 2016;PMID: 27325865. Full Text

Rand KA, Song C, Dean E, Serie DJ, Curtin K, Sheng X, Hu D, Huff CA, Bernal-Mizrachi L, Tomasson MH, Ailwadhi S, Singhal S, Pawlish KS, Peters ES, CH BL, Stram A, Van Den Berg DJ, Edlund CK, Conti DV, Zimmerman TM, Hwang AE, Huntsman S, Graff JJ, Nooka A, Kong Y, Pregja SL, Berndt SI, Blot WJ, Carpten JD, Casey G, Chu LW, Diver WR, Stevens VL, Lieber MR, Goodman PJ, Hennis AJ, Hsing AW, Mehta J, Kittles RA, Kolb S, Klein EA, Leske CM, Murphy AB, Nemesure B, Neslund- Dudas C, Strom SS, Vij R, Rybicki BA, Stanford JL, Signorello L, Witte JS, Ambrosone CB, Bhatti P, John EM, Bernstein L, Zheng W, Olshan AF, Hu JJ, Ziegler RG, Nyante SJ, Bandera EV, Birmann BM, Ingles SA, Press MF, Atanackovic D, Glenn M, Cannon-Albright L, Jones B, Tricot G, Martin TG, Kumar SK, Wolf JL, Deming SL, Rothman N, Brooks-Wilson A, Rajkumar SV, Kolonel LN, Chanock SJ, Slager SL, Severson RK, Janakirman N, Terebelo HJ, Brown EE, De Roos AJ, Mohrbacher A, Colditz GA, Giles GG, Spinelli JJ, Chiu BC, Munshi NC, Anderson KC, Levy J, Zonder JA, Orlowski RZ, Lonial S, Camp NJ, Vachon CM, Ziv E, Stram DO, Hazelett DJ, and Cozen W. A meta-analysis of multiple myeloma risk regions in African and European ancestry populations identifies putatively functional loci Cancer Epidemiol Biomarkers Prev 2016;PMID: 27587788. Article Request Form

Sabry OM, Goeger DE, Valeriote FA, and Gerwick WH. Cytotoxic halogenated monoterpenes from Plocamium cartilagineum Nat Prod Res 2016:1-7. PMID: 27627578. Article Request Form

Sak M, Duric N, Littrup P, Bey-Knight L, Ali H, Vallieres P, Sherman ME, and Gierach GL. Using speed of sound imaging to characterize breast density Ultrasound Med Biol 2016;PMID: 27692872. Full Text

Saste A, Arias-Stella J, and Kuriakose P. Progression of a hepatosplenic gamma delta T-cell leukemia/lymphoma on hyperCVAD/MTX and ara-C: literature review and our institutional treatment approach Clin Case Rep 2016; 4(1):67-71. PMID: 26783439. Full Text

Schering J, and Donthireddy V. Paraneoplastic syndrome in splenic marginal zone lymphoma: A rare phenomenon of paraplegia as an atypical presenting manifestation Case Rep Hematol 2016; 2016:7034167. PMID: 27293921. Full Text

Schwartz AG, Lusk CM, Wenzlaff AS, Watza D, Pandolfi S, Mantha L, Cote ML, Soubani AO, Walworth G, Wozniak A, Neslund-Dudas C, Ardisana AA, Flynn MJ, Song T, Spizarny DL, Kvale PA, Chapman RA, and Gadgeel SM. Risk of lung cancer associated with COPD phenotype based on quantitative image analysis Cancer Epidemiol Biomarkers Prev 2016; 25(9):1341-1347. PMID: 27383774. Article Request Form

Wang D, Braiteh F, Lee JJ, Denlinger CS, Shepard DR, Chaudhary A, Lin Y, Gao L, Asakiewicz C, Nasroulah F, and LoRusso P. Lack of pharmacokinetic drug-drug interaction between ramucirumab and irinotecan in patients with advanced solid tumors Cancer Chemother Pharmacol 2016;PMID: 27507037. 64 Full Text

Zhou Q, Abraham AD, Li L, Babalmorad A, Bagby S, Arcaroli JJ, Hansen RJ, Valeriote FA, Gustafson DL, Schaack J, Messersmith WA, and LaBarbera DV. Topoisomerase IIalpha mediates TCF- dependent epithelial-mesenchymal transition in colon cancer Oncogene 2016;PMID: 26947016. Full Text

Hematology/Oncology/Hemophilia and Thrombosis Treatment Center

McLaughlin JM, Lambing A, Witkop ML, Anderson TL, Munn J, and Tortella B. Racial differences in chronic pain and quality of life among adolescents and young adults with moderate or severe hemophilia J Racial Ethn Health Disparities 2016; 3(1):11-20. PMID: 26896101. Full Text

Witkop ML, McLaughlin JM, Anderson TL, Munn JE, Lambing A, and Tortella B. Predictors of non- adherence to prescribed prophylactic clotting-factor treatment regimens among adolescent and young adults with ableeding disorder Haemophilia 2016;PMID: 27216992. Full Text

65 Hypertension and Vascular Research

Cerrato BD, Carretero OA, Janic B, Grecco HE, and Gironacci MM. Heteromerization between the bradykinin b2 receptor and the angiotensin-(1-7) mas receptor: Functional consequences Hypertension 2016;PMID: 27550920. Full Text

Deshpande M, Mali VR, Pan G, Xu J, Yang XP, Thandavarayan RA, and Palaniyandi SS. Increased 4-hydroxy-2- nonenal-induced proteasome dysfunction is correlated with cardiac damage in streptozotocin-injected rats with isoproterenol infusion Cell Biochem Funct 2016; 34(5):334-342. PMID: 27273517. Full Text

Gonzalez GE, Rhaleb NE, D'Ambrosio MA, Nakagawa P, Liao TD, Peterson EL, Leung P, Dai X, Janic B, Liu YH, Yang XP, and Carretero OA. Cardiac-deleterious role of Galectin-3 in Angiotension II-induced Hypertension Am J Physiol Heart Circ Physiol 2016;PMID: 27496875. Full Text

Gonzalez-Vicente A, Saikumar JH, Massey KJ, Hong NJ, Dominici FP, Carretero OA, and Garvin JL. Angiotensin II stimulates superoxide production by nitric oxide synthase in thick ascending limbs Physiol Rep 2016; 4(4)PMID: 26884476. Full Text

Gordish KL, and Beierwaltes WH. Chronic resveratrol reverses a mild angiotensin II-induced pressor effect in a rat model Integr Blood Press Control 2016; 9:23-31. PMID: 26869812. Full Text

Gu X, Xu J, Zhu L, Bryson T, Yang XP, Peterson E, and Harding P. Prostaglandin e2 reduces cardiac contractility via ep3 receptor Circ Heart Fail 2016; 9(8)PMID: 27502370. Full Text

Haque MZ, McIntosh VJ, Abou Samra AB, Mohammad RM, and Lasley RD. Cholesterol depletion alters cardiomyocyte subcellular signaling and increases contractility PLoS One 2016; 11(7):e0154151. PMID: 27441649. Full Text

Karuppagounder V, Giridharan VV, Arumugam S, Sreedhar R, Palaniyandi SS, Krishnamurthy P, Quevedo J, Watanabe K, Konishi T, and Thandavarayan RA. Modulation of macrophage polarization and HMGB1-TLR2/TLR4 cascade plays a crucial role for cardiac remodeling in senescence- accelerated prone mice PLoS One 2016; 11(4):e0152922. PMID: 27070323. Full Text

Karuppagounder V, Arumugam S, Babu SS, Palaniyandi SS, Watanabe K, Cooke JP, and Thandavarayan RA. The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging Ageing Res Rev 2016;PMID: 27825897. Full Text

Kumar N, Nakagawa P, Janic B, Romero CA, Worou ME, Monu SR, Peterson EL, Shaw J, Valeriote F, Ongeri EM, Niyitegeka JV, Rhaleb NE, and Carretero OA. The anti-inflammatory peptide Ac-SDKP is released from thymosin beta4 by renal meprin alpha and prolyl oligopeptidase Am J Physiol Renal Physiol 2016:ajprenal.00562.02015. PMID: 26962108. Full Text

Kumar N, Astegno A, Chen J, Giorgetti A, and Dominici P. Residues in the distal heme pocket of arabidopsis non- symbiotic hemoglobins: Implication for nitrite reductase activity Int J Mol Sci 2016; 17(5)PMID: 27136534. Full Text

Mali VR, Pan G, Deshpande M, Thandavarayan RA, Xu J, Yang XP, and Palaniyandi SS. Cardiac mitochondrial respiratory dysfunction and tissue damage in chronic hyperglycemia correlate with reduced aldehyde dehydrogenase-2 activity PLoS One 2016; 11(10):e0163158. PMID: 27736868. Full Text

Munukutla S, Pan G, Deshpande M, Thandavarayan RA, Krishnamurthy P, and Palaniyandi SS. Alcohol toxicity in diabetes and its complications: A double trouble? Alcohol Clin Exp Res 2016;PMID: 27013182. Full Text

66 Ortiz PA. k+-mediated regulation of distal convoluted tubule na/cl cotransporter phosphorylation during angiotensin II-induced hypertension Hypertension 2016; 68(4):853-854. PMID: 27600180. Full Text

Pan G, Deshpande M, Thandavarayan RA, and Palaniyandi SS. ALDH2 Inhibition potentiates high glucose stress- induced injury in cultured cardiomyocytes J Diabetes Res 2016; 2016:1390861. PMID: 27882330. Full Text

Ren Y, Janic B, Kutskill K, Peterson EL, and Carretero OA. Mechanisms of connecting tubule glomerular feedback enhancement by aldosterone Am J Physiol Renal Physiol 2016:ajprenal.00076.02016. PMID: 27413197. Full Text

Romero C, Monu S, Cabral G, Knight R, and Carretero O. OS 21-02 Connecting tubule-glomerular feedback (ctgf) in renal hemodynamics and blood pressure regulation after unilateral nephrectomy (unx) J Hypertens 2016; 34 Suppl 1:e235. PMID: 27643022. Full Text

Sreedhar R, Giridharan VV, Arumugam S, Karuppagounder V, Palaniyandi SS, Krishnamurthy P, Quevedo J, Watanabe K, Konishi T, and Thandavarayan RA. Role of MAPK-mediated endoplasmic reticulum stress signaling in the heart during aging in senescence-accelerated prone mice Biofactors 2016;PMID: 27087487. Full Text

Staruschenko A, Ilatovskaya DV, and Pavlov TS. High salt diet and caffeine: food for thought J Thorac Dis 2016; 8(10):E1410-e1412. PMID: 27867643. Full Text

Zhu L, Yang XP, Janic B, Rhaleb NE, Harding P, Nakagawa P, Peterson EL, and Carretero OA. Ac-SDKP suppresses TNFalpha-induced ICAM-1 expression in endothelial cells via inhibition of IkappaB kinase and NF- kappaB activation Am J Physiol Heart Circ Physiol 2016:ajpheart.00252.02015. PMID: 26945075. Full Text

67 Infectious Diseases

Baker JV, Hullsiek KH, Engen NW, Nelson R, Chetchotisakd P, Gerstoft J, Jessen H, Losso M, Markowitz N, Munderi P, Papadopoulos A, Shuter J, Rappoport C, Pearson MT, Finley E, Babiker A, Emery S, and Duprez D. Early antiretroviral therapy at high cd4 counts does not improve arterial elasticity: A substudy of the strategic timing of antiretroviral treatment (start) trial Open Forum Infect Dis 2016; 3(4):ofw213. PMID: 27942541. Full text

Bardossy AC, Zervos J, and Zervos M. Preventing hospital-acquired infections in low-income and middle-income countries: Impact, gaps, and opportunities Infect Dis Clin North Am 2016; 30(3):805- 818. PMID: 27515149. Full Text

Bardossy AC, Jayaprakash R, Alangaden AC, Starr P, Abreu-Lanfranco O, Reyes K, Zervos MJ, and Alangaden GJ. Impact and limitations of the 2015 national health and safety network case definition on catheter- associated urinary tract infection rates Infect Control Hosp Epidemiol 2016:1- 3. PMID: 27881213. Full Text

Bourgi K, Brar I, and Baker-Genaw K. Health disparities in hepatitis c screening and linkage to care at an integrated health system in southeast michigan PLoS One 2016; 11(8):e0161241. PMID: 27525983. Full Text

Carreno JJ, Kenney RM, Divine G, Vazquez JA, and Davis SL. Randomized controlled trial to determine the efficacy of early switch from vancomycin to vancomycin alternatives as a strategy to prevent nephrotoxicity in patients with multiple risk factors for adverse renal outcomes (STOP-NT) Ann Pharmacother 2016;PMID: 27838680. Full Text

Cassone M, McNamara SE, Perri MB, Zervos M, and Mody L. Impact of intervention measures on MRSA clonal type and carriage site prevalence MBio 2016; 7(2)PMID: 26956588. Full Text

Chopra T, Awali RA, Biedron C, Vallin E, Bheemreddy S, Saddler CM, Mullins K, Echaiz JF, Bernabela L, Severson R, Marchaim D, Lephart P, Johnson L, Thyagarajan R, Kaye KS, and Alangaden G. Predictors of Clostridium difficile infection-related mortality among older adults Am J Infect Control 2016;PMID: 27424303. Full Text

Connolly MD, Zervos MJ, Barone CJ, 2nd, Johnson CC, and Joseph CL. The mental health of transgender youth: Advances in understanding J Adolesc Health 2016; 59(5):489-495. PMID: 27544457. Full Text

Davey R.T., Markowitz N., Beigel J., Wentworth D., Babiker A., Rehman T., Dewar R., Metcalf J., Uyeki T.M., Finley E.B., Standridge B., Riska P., Lane H.C., Gordin F., Neaton J.D., Denning E., Duchene A., Engen N., Harrison M., Quan K., Thompson G., Sanchez A., Hoover M., Natarajan V., Holley H.P., Tierney J., Voell J., Baxter J., Bigley D., Coburn P., Faber L., Gardner E., Harlow L., Jain M., Makohon L., Mcconnell R., Moghe J., Nahra R., Omotosho B., Petersen T., Polenakovik H., Rizza S., Scott J., Shoen A., Solorzano C., Temesgen Z., and J. W. INSIGHT FLU005: An Anti-Influenza Virus Hyperimmune Intravenous Immunoglobulin Pilot Study J Infect Dis 2016; 213(4):574-578. PMID: 26374911. Full Text

Gammon HM, Shelton CB, Siegert C, Dawson C, Sexton E, Burmeister C, Gnam G, and Siddiqui A. Self-turning for pressure injury prevention Wound Medicine 2016; 12:15-18. PMID: Not assigned Article Request Form

Gildeh E, Abdel-Rahman Z, Sengupta R, and Johnson L. A case of false-positive mycobacterium tuberculosis caused by mycobacterium celatum Case Rep Infect Dis 2016; 2016:1761923. PMID: 27895946. Full Text

Isseh IN, Bourgi K, Nakhle A, Ali M, and Zervos MJ. False-positive cerebrospinal fluid cryptococcus antigen in Libman-Sacks endocarditis Infection 2016;PMID: 27246719. Full Text

Kak V. Therapy for cellulitis Jama 2016; 316(19):2045-2046. PMID: 27838712. Full Text

68 Kaljee LM, Kilgore P, Prentiss T, Lamerato L, Moreno D, Arshad S, and Zervos M. 'You need to be an advocate for yourself': Factors associated with decision-making regarding influenza and pneumococcal vaccine use among U.S. older adults from within a large metropolitan health system Hum Vaccin Immunother 2016:0. PMID: 27625007. Article Request Form

Kenney RM, Cole KA, Perri MB, Dumkow LE, Samuel LP, Zervos MJ, and Davis SL. Reply to "urinary tract infections: Resistance is futile" Antimicrob Agents Chemother 2016; 60(4):2598. PMID: 27016558. Full Text

Kilgore PE, Salim AM, Zervos MJ, and Schmitt HJ. Pertussis: Microbiology, disease, treatment, and prevention Clin Microbiol Rev 2016; 29(3):449-486. PMID: 27029594. Article Request Form

Marty FM, Ostrosky-Zeichner L, Cornely OA, Mullane KM, Perfect JR, Thompson GR, 3rd, Alangaden GJ, Brown JM, Fredricks DN, Heinz WJ, Herbrecht R, Klimko N, Klyasova G, Maertens JA, Melinkeri SR, Oren I, Pappas PG, Racil Z, Rahav G, Santos R, Schwartz S, Vehreschild JJ, Young JH, Chetchotisakd P, Jaruratanasirikul S, Kanj SS, Engelhardt M, Kaufhold A, Ito M, Lee M, Sasse C, Maher RM, Zeiher B, and Vehreschild MJ. Isavuconazole treatment for mucormycosis: a single-arm open-label trial and case-control analysis Lancet Infect Dis 2016;PMID: 26969258. Full Text

Meighani A, Hart BR, Mittal C, Miller N, John A, and Ramesh M. Predictors of fecal transplant failure Eur J Gastroenterol Hepatol 2016;PMID: 26934528. Full Text

Murphy MV, Du DT, Hua W, Cortez KJ, Butler MG, Davis RL, DeCoster TA, Johnson L, Li L, Nakasato C, Nordin JD, Ramesh M, Schum M, Von Worley A, Zinderman C, Platt R, and Klompas M. Risk factors for surgical site infections following anterior cruciate ligament reconstruction Infect Control Hosp Epidemiol 2016; 37(7):827-833. PMID: 27340734. Full Text

Ordaya EE, and Alangaden GJ. Real-life use of isavuconazole in patients intolerant to other azoles Clin Infect Dis 2016;PMID: 27553376. Full Text

Orenstein R, Dubberke E, Hardi R, Ray A, Mullane K, Pardi DS, and Ramesh MS. Safety and durability of rbx2660 (microbiota suspension) for recurrent clostridium difficile infection: Results of the PUNCH CD study Clin Infect Dis 2016; 62(5):596-602. PMID: 26565008. Full Text

Petrie JG, Ohmit SE, Cheng CK, Martin ET, Malosh RE, Lauring AS, Lamerato LE, Reyes KC, Flannery B, Ferdinands JM, and Monto AS. Influenza vaccine effectiveness against antigenically drifted influenza higher than expected in hospitalized adults: 2014-2015 Clin Infect Dis 2016; PMID: 27369320. Full Text

Reyes K, Bardossy AC, and Zervos M. Vancomycin-resistant enterococci: Epidemiology, infection prevention, and control Infect Dis Clin North Am 2016;PMID: 27660091. Full Text

Shukla BS, Shelburne S, Reyes K, Kamboj M, Lewis JD, Rincon SL, Reyes J, Carvajal LP, Panesso D, Sifri CD, Zervos MJ, Pamer EG, Tran TT, Adachi J, Munita JM, Hasbun R, and Arias CA. Influence of MIC in Clinical Outcomes of Enterococcus faecium Bacteremia Treated with Daptomycin: Is It Time to Change the Breakpoint? Clin Infect Dis 2016;PMID: 27045126. Full Text

Singh N, Sifri CD, Silveira FP, Miller R, Gregg KS, Huprikar S, Lease ED, Zimmer A, Dummer JS, Spak CW, Koval C, Banach DB, Shroff M, Le J, Ostrander D, Avery R, Eid A, Razonable RR, Montero J, Blumberg E, Alynbiawi A, Morris MI, Randall HB, Alangaden G, Tessier J, Cacciarelli TV, Wagener MM, and Sun HY. Unique characteristics of cryptococcosis identified after death in patients with liver cirrhosis: comparison with concurrent cohort diagnosed antemortem Med Mycol 2016;PMID: 27601609. Article Request Form

Suleyman G, Perri M, Vager D, Samuel L, Zervos MJ, Alangaden G, and Tibbetts RJ. Characterization of Salmonella Isangi possessing a CTX-M15 ESBL associated with an outbreak in a US Hospital Diagn Microbiol Infect Dis 2016;PMID: 27130476. Full Text

69 Suleyman G, Tibbetts R, Perri MB, Vager D, Xin Y, Reyes K, Samuel L, Chami E, Starr P, Pietsch J, Zervos MJ, and Alangaden G. Nosocomial Outbreak of a Novel Extended-Spectrum beta- Lactamase Salmonella enterica Serotype Isangi Among Surgical Patients Infect Control Hosp Epidemiol 2016:1-8. PMID: 27108715. Article Request Form

Suleyman G, Kenney R, Zervos MJ, and Weinmann A. Safety and efficacy of outpatient parenteral antibiotic therapy in an academic infectious disease clinic J Clin Pharm Ther 2016;PMID: 27747899. Full Text

Suleyman G, and Zervos MJ. Safety and efficacy of commonly used antimicrobial agents in the treatment of enterococcal infections: a review Expert Opin Drug Saf 2016; 15(2):153-167. PMID: 26629598. Article request form

Suleyman G, and Alangaden GJ. Nosocomial fungal infections: Epidemiology, infection control, and prevention Infect Dis Clin North Am 2016; 30(4):1023-1052. PMID: 27816138. Full Text

70 Nephrology

Bou Chebl R, Madden B, Belsky J, Harmouche E, and Yessayan L. Diagnostic value of end tidal capnography in patients with hyperglycemia in the emergency department BMC Emerg Med 2016; 16(1):7. PMID: 26821648. Full Text

Desai T, Yee J, and Soman S. Smartphone apps: A patient's new best friend? Clin J Am Soc Nephrol 2016;PMID: 27173170. Full Text

Ishida JH, Patel A, Mehta AK, Gatault P, McBride JM, Burgess T, Derby MA, Snydman DR, Emu B, Feierbach B, Fouts AE, Maia M, Deng R, Rosenberger CM, Gennaro LA, Striano NS, Liao XC, and Tavel JA. Phase 2 randomized, double-blind, placebo-controlled trial of rg7667, a combination monoclonal antibody, for prevention of cytomegalovirus infection in high-risk kidney transplant recipients Antimicrob Agents Chemother 2016;PMID: 27872061. Full Text

Jalal D, McFadden M, Dwyer JP, Umanath K, Aguilar E, Yagil Y, Greco B, Sika M, Lewis JB, Greene T, and Goral S. Adherence rates to ferric citrate as compared to active control in patients with end stage kidney disease on dialysis Hemodial Int 2016;PMID: 27615161. Full Text

Kramer H, Yee J, Weiner DE, Bansal V, Choi MJ, Brereton L, Berns JS, Samaniego-Picota M, Scheel P, Jr., and Rocco M. Ultrafiltration rate thresholds in maintenance hemodialysis: An nkf-kdoqi controversies report Am J Kidney Dis 2016;PMID: 27449697. Full Text

Locatelli F, Mazzaferro S, and Yee J. Iron therapy challenges for the treatment of nondialysis CKD patients Clin J Am Soc Nephrol 2016;PMID: 27185524. Full Text

Ma J, Patel A, and Tinckam K. Donor-specific antibody monitoring: Where is the beef? Adv Chronic Kidney Dis 2016; 23(5):317-325. PMID: 27742387. Full Text

Matzumura M, Arias-Stella J, 3rd, and Novak JE. Erdheim-chester disease: A rare presentation of a rare disease J Investig Med High Impact Case Rep 2016; 4(3):2324709616663233. PMID: 27606325. Full Text

Neyra JA, Canepa-Escaro F, Yee J, and Yessayan L. The authors reply Crit Care Med 2016; 44(1):e53-54. PMID: 26672946. Full Text

Neyra JA, Li X, Canepa-Escaro F, Adams-Huet B, Toto RD, Yee J, and Hedayati SS. Cumulative fluid balance and mortality in septic patients with or without acute kidney injury and chronic kidney disease Crit Care Med 2016;PMID: 27352125. Full Text

Patel AK, and Samaniego M. The struggle for optimization of long-term outcomes after kidney transplantation Adv Chronic Kidney Dis 2016; 23(5):280. PMID: 27742380. Full Text

Prashar R, and Venkat KK. Immunosuppression minimization and avoidance protocols: When less is not more Adv Chronic Kidney Dis 2016; 23(5):295-300. PMID: 27742383. Full Text

Provenzano R, Besarab A, Sun CH, Diamond SA, Durham JH, Cangiano JL, Aiello JR, Novak JE, Lee T, Leong R, Roberts BK, Saikali KG, Hemmerich S, Szczech LA, Yu KP, and Neff TB. Oral hypoxia- inducible factor prolyl hydroxylase inhibitor roxadustat (fg-4592) for the treatment of anemia in patients with ckd Clin J Am Soc Nephrol 2016;PMID: 27094610. Full Text

Rocco MV, Chapman A, Chertow GM, Cohen D, Chen J, Cutler JA, Diamond MJ, Freedman BI, Hawfield A, Judd E, Killeen AA, Kirchner K, Lewis CE, Pajewski NM, Wall BM, and Yee J. Chronic kidney disease classification in systolic blood pressure intervention trial: Comparison using modification of diet in renal disease and ckd-epidemiology collaboration definitions Am J Nephrol 2016; 44(2):130- 140. PMID: 27513312. Article Request Form

Soi V, Moore CL, Kumbar L, and Yee J. Prevention of catheter-related bloodstream infections in patients on hemodialysis: challenges and management strategies Int J Nephrol Renovasc Dis 2016; 9:95-103. PMID: 27143948. Full Text

71

Szamosfalvi B, Westover A, Buffington D, Yevzlin A, and Humes HD. Immunomodulatory device promotes a shift of circulating monocytes to a less inflammatory phenotype in chronic hemodialysis patients Asaio j 2016;PMID: 27258222. Full Text

Takahashi K, Patel AK, Putchakayala KG, Denny JE, Kim DY, and Malinzak LE. Arterioenteric fistula 12 years after kidney transplant Kidney Int 2016; 90(3):710. PMID: 27521122. Full Text

Townsend RR, Chang TI, Cohen DL, Cushman WC, Evans GW, Glasser SP, Haley WE, Olney C, Oparil S, Del Pinto R, Pisoni R, Taylor AA, Umanath K, Wright JT, Jr., and Yeboah J. Orthostatic changes in systolic blood pressure among SPRINT participants at baseline J Am Soc Hypertens 2016;PMID: 27665708. Full Text

Umeukeje EM, Merighi JR, Browne T, Wild M, Alsmaan H, Umanath K, Lewis JB, Wallston KA, and Cavanaugh KL. Health care providers' support of patients' autonomy, phosphate medication adherence, race and gender in end stage renal disease J Behav Med 2016;PMID: 27167227. Full Text

Weir MR, Pearson TC, Patel A, Peddi VR, Kalil R, Scandling J, Chan L, Baliga P, Melton L, Mulgaonkar S, Waid T, Schaefer H, Youssef N, Anandagoda L, McCollum D, Lawson S, and Gordon R. Long-term follow-up of kidney transplant recipients in the spare-the-nephron-trial Transplantation 2016;PMID: 26950714. Full Text

Wish JB, Charytan C, Chertow GM, Kalantar-Zadeh K, Kliger AS, Rubin RJ, Yee J, and Fishbane S. Introduction of biosimilar therapeutics into nephrology practice in the united states: Report of a scientific workshop sponsored by the national kidney foundation Am J Kidney Dis 2016;PMID: 27599628. Full Text

Yee J. Geriatric CKD: Value-based nephrology Adv Chronic Kidney Dis 2016; 23(1):1-5. PMID: 26709055. Full Text

Yee J. PGX: Pharmacogenomics during generation X Adv Chronic Kidney Dis 2016; 23(2):57-60. PMID: 26979142. Full Text

Yee J. Intensive care unit renal replacement therapy: Less is more (or better) Adv Chronic Kidney Dis 2016; 23(3):131-133. PMID: 27113686. Full Text

Yee J. Improving transitions in CKD: failure mode Adv Chronic Kidney Dis 2016; 23(4):211-214. PMID: 27324671. Full Text

Yee J. Increasing access to kidney transplantation: Easy as A-B-O Adv Chronic Kidney Dis 2016; 23(5):277-279. PMID: 27742379. Full Text

Yessayan L, Yee J, Frinak S, and Szamosfalvi B. Continuous renal replacement therapy for the management of acid-base and electrolyte imbalances in acute kidney injury Adv Chronic Kidney Dis 2016; 23(3):203-210. PMID: 27113697. Full Text

Yessayan L, Moore C, Lu M, and Yee J. Bone-specific alkaline phosphatase and bone turnover in African American hemodialysis patients Hemodial Int 2016;PMID: 27350216. Full Text

72 Pulmonary and Critical Care Medicine

Abrencillo RA, Khemasuwan D, and Diaz-Mendoza JI. A Young Man with Acute Progressive Respiratory Distress and a Right Inguinal Mass Ann Am Thorac Soc 2016; 13(6):970-975. PMID: 27295158. Full Text

Alkhatib Y, Albashaireh D, Al-Aqtash T, and Awdish R. The role of tyrosine kinase inhibitor "Lapatinib" in pulmonary hypertension Pulm Pharmacol Ther 2016; 37:81-84. PMID: 26965087. Full Text

Attaway A, Sroujieh L, Mersfelder TL, Butler C, and Ouellette D. "Ping-pong gaze" secondary to monoamine oxidase inhibitor overdose J Pharmacol Pharmacother 2016; 7(1):34-37. PMID: 27127395. Full Text

Azuh O, Gammon H, Burmeister C, Frega D, Nerenz D, DiGiovine B, and Siddiqui A. Benefits of early active mobility in the medical intensive care unit - a pilot study Am J Med 2016;PMID: 27107920. Full Text

Bou Chebl R, Madden B, Belsky J, Harmouche E, and Yessayan L. Diagnostic value of end tidal capnography in patients with hyperglycemia in the emergency department BMC Emerg Med 2016; 16(1):7. PMID: 26821648. Full Text

Diekemper RL, Patel S, Mette SA, Ornelas J, Ouellette DR, and Casey KR. Making the GRADE: CHEST updates its methodology Chest 2016;PMID: 27142185. Full Text

Girard TD, Alhazzani W, Kress JP, Ouellette DR, Schmidt GA, Truwit JD, Burns SM, Epstein SK, Esteban A, Fan E, Ferrer M, Fraser GL, Gong M, Hough C, Mehta S, Nanchal R, Patel S, Pawlik AJ, Sessler CN, Strom T, Schweickert W, Wilson KC, and Morris PE. An official american thoracic society/American college of chest physicians clinical practice guideline: Liberation from mechanical ventilation in critically ill adults. Rehabilitation protocols, ventilator liberation protocols, and cuff leak tests Am J Respir Crit Care Med 2016;PMID: 27762595. Full Text

Hohenforst-Schmidt W, Zarogoulidis P, Pitsiou G, Linsmeier B, Tsavlis D, Kioumis I, Papadaki E, Freitag L, Tsiouda T, Turner JF, Browning R, Simoff M, Sachpekidis N, Tsakiridis K, Zaric B, Yarmus L, Baka S, Stratakos G, and Rittger H. Drug eluting stents for malignant airway obstruction: A critical review of the literature J Cancer 2016; 7(4):377-390. PMID: 26918052. Full Text

Horng M, Mohammad I, Smith ZR, Awdish RL, and Cajigas HR. Inhaled iloprost for chronic thromboembolic pulmonary hypertension (CTEPH) during pregnancy: a case report Pharmacotherapy 2016;PMID: 27341074. Full Text

Ketterer MW, Alaali Y, Yessayan L, and Jennings J. "Alert and oriented x 3?" Correlates of mini-cog performance in a post/nondelirious intensive care unit sample Psychosomatics 2015;PMID: 26805587. Full Text

Nguyen HB, Jaehne AK, Jayaprakash N, Semler MW, Hegab S, Yataco AC, Tatem G, Salem D, Moore S, Boka K, Gill JK, Gardner-Gray J, Pflaum J, Domecq JP, Hurst G, Belsky JB, Fowkes R, Elkin RB, Simpson SQ, Falk JL, Singer DJ, and Rivers EP. Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE Crit Care 2016; 20(1):160. PMID: 27364620. Full Text

O'Connell OJ, Almeida FA, Simoff MJ, Yarmus L, Lazarus R, Young B, Chen Y, Semaan R, Saettele TM, Cicenia J, Bedi H, Kliment C, Li L, Sethi S, Diaz-Mendoza J, Feller-Kopman D, Song J, Gildea T, Lee H, Grosu HB, Machuzak M, Rodriguez-Vial M, Eapen GA, Jimenez CA, Casal RF, and Ost DE. A Prediction Model to Help with the Assessment of Adenopathy in Lung Cancer (HAL) Am J Respir Crit Care Med 2016;PMID: 28002683. Full text

73 Ost DE, Ernst A, Lei XD, Kovitz KL, Benzaquen S, Diaz-Mendoza J, Greenhill S, Toth J, Feller- Kopman D, Puchalski J, Baram D, Karunakara R, Jimenez CA, Filner JJ, Morice RC, Eapen GA, Michaud GC, Estrada-Y-Martin RM, Rafeq S, Grosu HB, Ray C, Gilbert CR, Yarmus LB, Simoff M, and Registry AQB. Diagnostic yield and complications of bronchoscopy for peripheral lung lesions results of the AQuIRE registry Am J Respir Crit Care Med 2016; 193(1):68-77. PMID: 26367186. Full Text

Ouellette DR, Patel S, Girard TD, Morris PE, Schmidt GA, Truwit JD, Al-Hazzani W, Burns SM, Epstein SK, Esteban A, Fan E, Ferrer M, Fraser GL, Gong M, Hough CL, Mehta S, Nanchal R, Pawlik AJ, Schweickert W, Sessler CN, Strom T, and Kress JP. Liberation from mechanical ventilation: An official american college of chest physicians/american thoracic society clinical practice guideline: Inspiratory pressure augmentation during spontaneous breathing trials, protocols minimizing sedation, and non- invasive ventilation immediately after extubation Chest 2016;PMID: 27818331. Full Text

Rezik MM, and Ouellette DR. Pleuritic chest pain in a 24-year-old male with crohn's disease Am J Respir Crit Care Med 2016;PMID: 27413816. Full Text.

Schmidt GA, Girard TD, Kress JP, Morris PE, Ouellette DR, Alhazzani W, Burns SM, Epstein SK, Esteban A, Fan E, Ferrer M, Fraser GL, Gong M, Hough C, Mehta S, Nanchal R, Patel S, Pawlik AJ, Sessler CN, Strom T, Schweickert W, Wilson KC, and Truwit JD. Official executive summary of an American thoracic society/american college of chest physicians clinical practice guideline: Liberation from mechanical ventilation in critically ill adults Am J Respir Crit Care Med 2016;PMID: 27762608. Full Text

Schwartz AG, Lusk CM, Wenzlaff AS, Watza D, Pandolfi S, Mantha L, Cote ML, Soubani AO, Walworth G, Wozniak A, Neslund-Dudas C, Ardisana AA, Flynn MJ, Song T, Spizarny DL, Kvale PA, Chapman RA, and Gadgeel SM. Risk of lung cancer associated with COPD phenotype based on quantitative image analysis Cancer Epidemiol Biomarkers Prev 2016; 25(9):1341-1347. PMID: 27383774. Article Request Form

Shah SK, Jennings JH, Diaz-Mendoza JI, Yessayan L, Ray C, and Simoff MJ. Removal of self- expanding metallic stents J Bronchology Interv Pulmonol 2016; 23(4):279-282. PMID: 27764006. Full Text

Smith ZR, Makowski CT, and Awdish RL. Treatment of patients with chronic thrombo embolic pulmonary hypertension: focus on riociguat Ther Clin Risk Manag 2016; 12:957-964. PMID: 27354811. Full Text

Thompson MP, Reeves MJ, Bogan BL, DiGiovine B, Posa PJ, and Watson SR. Protocol-based resuscitation bundle to improve outcomes in septic shock patients: Evaluation of the michigan health and hospital association keystone sepsis collaborative Crit Care Med 2016;PMID: 27441897. Full Text

74 Pulmonary/Sleep Medicine

Cheng P, and Drake C. Occupational sleep medicine Sleep Med Clin 2016; 11(1):65-79. PMID: 26972034. Full Text

Connor KM, Mahoney E, Jackson S, Hutzelmann J, Zhao X, Jia N, Snyder E, Snavely D, Michelson D, Roth T, and Herring WJ. A phase II dose-ranging study evaluating the efficacy and safety of the orexin receptor antagonist filorexant (mk-6096) in patients with primary insomnia Int J Neuropsychopharmacol 2016;PMID: 26979830. Full Text

Drake CL. The promise of digital CBT-I Sleep 2016; 39(1):13-14. PMID: 26564140. Full Text

Espie CA, Luik AI, Cape J, Drake CL, Siriwardena AN, Ong JC, Gordon C, Bostock S, Hames P, Nisbet M, Sheaves B, R GF, Freeman D, Costa-Font J, Emsley R, and Kyle SD. Digital Cognitive Behavioural Therapy for Insomnia versus sleep hygiene education: the impact of improved sleep on functional health, quality of life and psychological well-being. Study protocol for a randomised controlled trial Trials 2016; 17(1):257. PMID: 27216112. Full Text

Gelaye B, Zhong QY, Barrios YV, Redline S, Drake CL, and Williams MA. Psychometric evaluation of the ford insomnia response to stress test (FIRST) in early pregnancy J Clin Sleep Med 2016; 12(4):579-587. PMID: 26857055. Full Text

Herring WJ, Connor KM, Ivgy-May N, Snyder E, Liu K, Snavely DB, Krystal AD, Walsh JK, Benca RM, Rosenberg R, Sangal RB, Budd K, Hutzelmann J, Leibensperger H, Froman S, Lines C, Roth T, and Michelson D. Suvorexant in patients with insomnia: Results from two 3-month randomized controlled clinical trials Biol Psychiatry 2016; 79(2):136-148. PMID: 25526970. Full Text

Jarrin DC, Chen IY, Ivers H, Drake CL, and Morin CM. Temporal stability of the ford insomnia response to stress test (FIRST) J Clin Sleep Med 2016; 12(10):1373-1378. PMID: 27568895. Full Text

Kalmbach DA, Pillai V, Arnedt JT, and Drake CL. Identifying at-risk individuals for insomnia using the ford insomnia response to stress test Sleep 2016; 39(2):449-456. PMID: 26446111. Full Text

Kalmbach DA, Pillai V, Arnedt JT, Anderson JR, and Drake CL. Sleep system sensitization: evidence for changing roles of etiological factors in insomnia Sleep Med 2016; 21:63-69. PMID: 27448474. Full Text

Kalmbach DA, Pillai V, Arnedt JT, and Drake CL. DSM-5 Insomnia and short sleep: Comorbidity landscape and racial disparities Sleep 2016;PMID: 27634805. Full text

Komada Y, Breugelmans R, Drake CL, Nakajima S, Tamura N, Tanaka H, Inoue S, and Inoue Y. Social jetlag affects subjective daytime sleepiness in school-aged children and adolescents: A study using the Japanese version of the Pediatric Daytime Sleepiness Scale (PDSS-J) Chronobiol Int 2016:1-9. PMID: 27715324. Article request form

Marques DR, Allen Gomes A, Drake CL, Roth T, and de Azevedo MH. Assessing stress-induced sleep reactivity in college students: The European Portuguese version of the Ford insomnia response to stress test (FIRST) Behav Sleep Med 2016:1-12. PMID: 27712109. Article request form

Muzet A, Werner S, Fuchs G, Roth T, Saoud JB, Viola AU, Schaffhauser JY, and Luthringer R. Assessing sleep architecture and continuity measures through the analysis of heart rate and wrist movement recordings in healthy subjects: comparison with results based on polysomnography Sleep Med 2016; 21:47-56. PMID: 27448472. Full Text

Ondo WG, Grieger F, Moran K, Kohnen R, and Roth T. Post hoc analysis of data from two clinical trials evaluating the minimal clinically important change in international restless legs syndrome sum score in patients with restless legs syndrome (Willis-Ekbom Disease) J Clin Sleep Med 2016; 12(1):63-70. PMID: 26446245. Full Text

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Palagini L, Bruno RM, Cheng P, Mauri M, Taddei S, Ghiadoni L, Drake CL, and Morin CM. Relationship between insomnia symptoms, perceived stress and coping strategies in subjects with arterial hypertension: psychological factors may play a modulating role Sleep Med 2016; 19:108-115. PMID: 27198955. Full Text

Palagini L, Mauri M, Dell'Osso L, Riemann D, and Drake CL. Trait- and pre-sleep-state-dependent arousal in insomnia disorders: what role may sleep reactivity and sleep-related metacognitions play? A pilot study Sleep Med 2016; 25:42-48. PMID: 27823715. Full Text

Parthasarathy S, Carskadon MA, Jean-Louis G, Owens J, Bramoweth A, Combs D, Hale L, Harrison E, Hart CN, Hasler BP, Honaker SM, Hertenstein E, Kuna S, Kushida C, Levenson JC, Murray C, Pack AI, Pillai V, Pruiksma K, Seixas A, Strollo P, Thosar SS, Williams N, and Buysse D. Implementation of sleep and circadian science: Recommendations from the sleep research society and national institutes of health workshop Sleep 2016;PMID: 27748248. Full text

Pillai V, Cheng P, Kalmbach DA, Roehrs T, Roth T, and Drake CL. Prevalence and predictors of prescription sleep aid use among individuals with dsm-5 insomnia: The role of hyperarousal Sleep 2016; 39(4):825-832. PMID: 26943472.

Pillai V, Roth T, and Drake CL. Towards quantitative cutoffs for insomnia: how current diagnostic criteria mischaracterize remission Sleep Med 2016;PMID: 27288048. Full Text

Roehrs TA, and Roth T. Gender differences in the efficacy and safety of chronic nightly zolpidem J Clin Sleep Med 2016; 12(3):319-325. PMID: 26446253. Full Text

Roehrs TA, and Roth T. Hyperarousal in insomnia and hypnotic dose escalation Sleep Med 2016; 23:16-20. PMID: 27692272. Full Text

Roth T, Dauvilliers Y, Guinta D, Alvarez-Horine S, Dynin E, and Black J. Effect of sodium oxybate on disrupted nighttime sleep in patients with narcolepsy J Sleep Res 2016;PMID: 27807903. Full Text

Ruwe F, Ijzerman-Boon P, Roth T, Zammit G, and Ivgy-May N. A phase 2 randomized dose-finding study with esmirtazapine in patients with primary insomnia J Clin Psychopharmacol 2016;PMID: 27482970. Full Text

Wickwire EM, Williams SG, Roth T, Capaldi VF, Jaffe M, Moline M, Motamedi GK, Morgan GW, Mysliwiec V, Germain A, Pazdan RM, Ferziger R, Balkin TJ, MacDonald ME, Macek TA, Yochelson MR, Scharf SM, and Lettieri CJ. Sleep, sleep disorders, and mild traumatic brain injury. What we know and what we need to know: Findings from a national working group Neurotherapeutics 2016;PMID: 27002812. Article Request Form

Wickwire EM, Geiger-Brown J, Scharf SM, and Drake CL. Shift work and shift work sleep disorder: Clinical and organizational perspectives Chest 2016;PMID: 28012806. Full text

76 Rheumatology

Coit P, Dozmorov MG, Merrill JT, McCune WJ, Maksimowicz-McKinnon K, Wren JD, and Sawalha AH. Epigenetic reprogramming in naive CD4+ T cells favoring T cell activation and non-Th1 effector T cell immune response as an early event in lupus flares Arthritis Rheumatol 2016;PMID: 27111767. Full Text

Li B, Singer NG, Yeni YN, Haggins DG, Barnboym E, Oravec D, Lewis S, and Akkus O. A point of care Raman spectroscopy based device to diagnose gout and pseudogout: Comparison with the clinical standard microscopic analysis Arthritis Rheumatol 2016;PMID: 26882173. Full Text

Namas R, and Meysami A. Sarcoidosis of hands J Clin Rheumatol 2016; 22(5):278-279. PMID: 27464776. Full Text

77 General Internal Medicine/Palliative Medicine/Other

Abed F, Baniya R, and Bachuwa G. Quinine-induced disseminated intravascular coagulation Case Rep Med 2016; 2016:9136825. PMID: 27293443. Full Text

Abid Z, Oh SS, Hu D, Sen S, Huntsman S, Eng C, Farber HJ, Rodriguez-Cintron W, Rodriguez- Santana JR, Serebrisky D, Avila PC, Thyne SM, Kim KA, Borrell LN, Williams LK, Seibold MA, Burchard EG, and Kumar R. Maternal age and asthma in Latino populations Clin Exp Allergy 2016; 46(11):1398-1406. PMID: 27238356. Full Text

Baker-Genaw K, Kokas MS, Ahsan SF, Darnley-Fisch D, Drake S, Goyal N, Inamdar K, Moutzouros V, Prabhakar D, Rolland L, Sangha R, Shreve M, and Woodward A. Mapping direct observations from objective structured clinical examinations to the milestones across specialties J Grad Med Educ 2016; 8(3):429-434. PMID: 27413450. Full Text

Barnes GD, Kurlander J, Haymart B, Kaatz S, Saini S, and Froehlich JB. Bridging anticoagulation before colonoscopy: Results of a multispecialty clinician survey JAMA Cardiol 2016;PMID: 27627046. Full Text

Batra AK, Alomari A, Chilvery AK, Bandyopadhyay A, and Grover K. Piezoelectric power harvesting devices: An overview Adv Sci Eng Med 2016; 8(1):1-12. PMID: Not assigned. Article Request Form

Bourgi K, Brar I, and Baker-Genaw K. Health disparities in hepatitis c screening and linkage to care at an integrated health system in southeast michigan PLoS One 2016; 11(8):e0161241. PMID: 27525983. Full Text

Brown-Deacon C, Brown T, Creech C, McFarland M, Nair A, and Whitlow K. Can follow-up phone calls improve patients self-monitoring of blood glucose? J Clin Nurs 2016;PMID: 27862497. Full Text

Cajigal S, Wells KE, Peterson EL, Ahmedani BK, Yang JJ, Kumar R, Burchard EG, and Williams LK. Predictive properties of the asthma control test and its component questions for severe asthma exacerbations J Allergy Clin Immunol Pract 2016;PMID: 27544712. Full Text

El-Refai M, Hrobowski T, Peterson EL, Wells K, Spertus JA, Williams LK, and Lanfear DE. Race and association of angiotensin converting enzyme/angiotensin receptor blocker exposure with outcome in heart failure J Cardiovasc Med (Hagerstown) 2015; 16(9):591-596. PMID: 24842464. Full Text

Essenmacher AC, Khurram N, and Bismack GT. A case of reactive arthritis due to colitis J Community Hosp Intern Med Perspect 2016; 6(1):30151. PMID: 26908381. Full Text

Gildeh E, Abdel-Rahman Z, Sengupta R, and Johnson L. A case of false-positive mycobacterium tuberculosis caused by mycobacterium celatum Case Rep Infect Dis 2016; 2016:1761923. PMID: 27895946. Full Text

Guzman Rojas P, Gallegos Lopez R, Ciliotta Chehade A, Scavino Y, Morales A, and Tagle M. [Autoimmune hepatitis induced by isotretionine] Article in Spanish Rev Gastroenterol Peru 2016; 36(1):86-89. PMID: 27131947. Article Request Form

Hale ZD, Kong X, Haymart B, Gu X, Kline-Rogers E, Almany S, Kozlowski J, Krol GD, Kaatz S, Froehlich JB, and Barnes GD. Prescribing trends of atrial fibrillation patients who switched from warfarin to a direct oral anticoagulant J Thromb Thrombolysis 2016;PMID: 27837309. Full Text

Heidemann DL, Joseph NA, Kuchipudi A, Perkins DW, and Drake S. Racial and economic disparities in diabetes in a large primary care patient population Ethn Dis 2016; 26(1):85-90. PMID: 26843800. Article Request Form

Heidemann DL, Thompson E, and Drake SM. Does timing of internal medicine residency interview affect likelihood of matching? South Med J 2016; 109(8):466-470. PMID: 27490656. Full Text 78 Henein F, Prabhakar D, Peterson EL, Williams LK, and Ahmedani BK. A prospective study of antidepressant adherence and suicidal ideation among adults Prim Care Companion CNS Disord 2016; 18(6)PMID: 27907275. Article Request Form

Hermann G, Xi AS, Stevens B, and Goyal N. Reducing errors in reporting scholarly activity to the ACGME: The annual update scholarly activity monitoring tool J Grad Med Educ 2016; 8(3):447-448. PMID: 27413457. Full Text

Hourmozdi JJ, Markin A, Johnson B, Fleming PR, and Miller JB. Routine chest radiography is not necessary after ultrasound-guided right internal jugular vein catheterization Crit Care Med 2016;PMID: 27035241. Full Text

Kessler MD, Yerges-Armstrong L, Taub MA, Shetty AC, Maloney K, Jeng LJ, Ruczinski I, Levin AM, Williams LK, Beaty TH, Mathias RA, Barnes KC, and O'Connor TD. Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry Nat Commun 2016; 7:12521. PMID: 27725664. Full Text

Kueht M, Bebko S, Helmick R, and Awad S. Hepatitis C status and infectious complications in the surgical intensive care unit: a retrospective analysis of 1,941 consecutive patients Am J Surg 2016; 211(6):1064-1070. PMID: 26746567. Full Text

Mathias RA, Taub MA, Gignoux CR, Fu W, Musharoff S, O'Connor TD, Vergara C, Torgerson DG, Pino-Yanes M, Shringarpure SS, Huang L, Rafaels N, Boorgula MP, Johnston HR, Ortega VE, Levin AM, Song W, Torres R, Padhukasahasram B, Eng C, Mejia-Mejia DA, Ferguson T, Qin ZS, Scott AF, Yazdanbakhsh M, Wilson JG, Marrugo J, Lange LA, Kumar R, Avila PC, Williams LK, Watson H, Ware LB, Olopade C, Olopade O, Oliveira R, Ober C, Nicolae DL, Meyers D, Mayorga A, Knight-Madden J, Hartert T, Hansel NN, Foreman MG, Ford JG, Faruque MU, Dunston GM, Caraballo L, Burchard EG, Bleecker E, Araujo MI, Herrera-Paz EF, Gietzen K, Grus WE, Bamshad M, Bustamante CD, Kenny EE, Hernandez RD, Beaty TH, Ruczinski I, Akey J, and Barnes KC. A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome Nat Commun 2016; 7:12522. PMID: 27725671. Full Text

Miller-Matero LR, Dykuis KE, Albujoq K, Martens K, Fuller BS, Robinson V, and Willens DE. Benefits of integrated behavioral health services: The physician perspective Fam Syst Health 2016; 34(1):51-55. PMID: 26963777. Full Text

Milling TJ, Jr., and Kaatz S. Preclinical and clinical data for factor xa and "universal" reversal agents Am J Med 2016;PMID: 27575436. Full Text

Milling TJ, Jr., and Kaatz S. Preclinical and clinical data for factor Xa and "Universal" reversal agents Am J Emerg Med 2016;PMID: 27697443. Full Text

Minhas AS, Jiang Q, Gu X, Haymart B, Kline-Rogers E, Almany S, Kozlowski J, Krol GD, Kaatz S, Froehlich JB, and Barnes GD. Renal function in atrial fibrillation patients switched from warfarin to a direct oral anticoagulant J Thromb Thrombolysis 2016;PMID: 27217043. Full Text

Murad MH, Guyatt GH, Domecq JP, Vernooij RW, Erwin PJ, Meerpohl JJ, Prutsky GJ, Akl EA, Mueller K, Bassler D, Schandelmaier S, Walter SD, Busse JW, Kasenda B, Pagano G, Pardo-Hernandez H, Montori VM, Wang Z, and Briel M. Randomized trials addressing a similar question are commonly published after a trial stopped early for benefit J Clin Epidemiol 2016;PMID: 27832953. Full Text

Nguyen HB, Jaehne AK, Jayaprakash N, Semler MW, Hegab S, Yataco AC, Tatem G, Salem D, Moore S, Boka K, Gill JK, Gardner-Gray J, Pflaum J, Domecq JP, Hurst G, Belsky JB, Fowkes R, Elkin RB, Simpson SQ, Falk JL, Singer DJ, and Rivers EP. Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE Crit Care 2016; 20(1):160. PMID: 27364620. Full Text

79 Oh S, Du R, Zeiger AM, McGarry ME, Hu D, Thakur N, Pino-Yanes M, Galanter JM, Farber HJ, Eng C, Nishimura KK, Huntsman S, Meade K, Avila P, Serebrisky D, Bibbins-Domingo K, Lenoir MA, Ford JG, Brigino-Buenaventura E, Rodriguez-Cintron W, Thyne SM, Sen S, Rodriguez-Santana JR, Williams K, Kumar R, and Burchard EG. Breastfeeding associated with higher lung function in African American youths with asthma J Asthma 2016:0. PMID: 27929698. Full text

Palmer TR. Re: A trial of shuangbai san for treating primary liver cancer patients with cancer pain J Pain Symptom Manage 2016;PMID: 27713032. Full Text

Prutsky G, Domecq JP, Salazar CA, and Accinelli R. Antifibrinolytic therapy to reduce haemoptysis from any cause Cochrane Database Syst Rev 2016; 11:Cd008711. PMID: 27806184. Full Text

Qureshi W, Ali Z, Amjad W, Alirhayim Z, Farooq H, Qadir S, Khalid F, and Al-Mallah MH. Venous thromboembolism in cancer: An update of treatment and prevention in the era of newer anticoagulants Front Cardiovasc Med 2016; 3:24. PMID: 27517038. Full Text

Salem D, and Alchakaki A. Treatment of severe ace inhibitor angioedema: Current and future therapies Consultant 2016; 56(2):134-137. PMID: Not assigned. Article Request Form

Sleder A, Tackett S, Cerasale M, Mittal C, Isseh I, Radjef R, Taylor A, Farha R, Lupak O, Larkin D, Lamerato L, Divine G, Wisdom K, Baker-Genaw K, and O'Neill W. Socioeconomic and racial disparities: A case-control study of patients receiving transcatheter aortic valve replacement for severe aortic stenosis J Racial Ethn Health Disparities 2016;PMID: 28039604. Article Request Form

Syed H, Bachuwa G, Upadhaya S, and Abed F. Nitrofurantoin-induced interstitial pneumonitis: albeit rare, should not be missed BMJ Case Rep 2016; 2016PMID: 26912767. Full Text

Wells KE, Cajigal S, Peterson EL, Ahmedani BK, Kumar R, Lanfear DE, Burchard EG, and Williams LK. Assessing differences in inhaled corticosteroid response by self-reported race-ethnicity and genetic ancestry among asthmatic subjects J Allergy Clin Immunol 2016;PMID: 27016472. Full Text

Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorsky M, Zidzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkac I, Kooy A, van Schaik RH, Stehouwer CD, Logie L, Sutherland C, Klovins J, Pirags V, Hofman A, Stricker BH, Motsinger-Reif AA, Wagner MJ, Innocenti F, Hart LM, Holman RR, McCarthy MI, Hedderson MM, Palmer CN, Florez JC, Giacomini KM, and Pearson ER. Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin Nat Genet 2016;PMID: 27500523. Full Text

80 NEUROLOGY

Achyut BR, Shankar A, Iskander AS, Ara R, Knight RA, Scicli AG, and Arbab AS. Chimeric mouse model to track the migration of bone marrow derived cells in glioblastoma following anti-angiogenic treatments Cancer Biol Ther 2016:0. PMID: 26797476. Article Request Form

Barone FC, Gustafson D, Crystal HA, Moreno H, Adamski MG, Arai K, Baird AE, Balucani C, Brickman AM, Cechetto D, Gorelick P, Biessels GJ, Kiliaan A, Launer L, Schneider J, Sorond FA, Whitmer R, Wright C, and Zhang ZG. First translational 'Think Tank' on cerebrovascular disease, cognitive impairment and dementia J Transl Med 2016; 14(1):50. PMID: 26873444. Full Text

Brennan JR, Wagley N, Kovelman I, Bowyer SM, Richard AE, and Lajiness-O'Neill R. Magnetoencephalography shows atypical sensitivity to linguistic sound sequences in autism spectrum disorder Neuroreport 2016; 27(13):982- 986. PMID: 27468112. Full Text

Cui C, Ye X, Chopp M, Venkat P, Zacharek A, Yan T, Ning R, Yu P, Cui G, and Chen J. Mir-145 regulates diabetes-bone marrow stromal cell-induced neurorestorative effects in diabetes stroke rats Stem Cells Transl Med 2016;PMID: 27460851. Article Request Form

Cui X, Chopp M, Zhang Z, Li R, Zacharek A, Landschoot-Ward J, Venkat P, and Chen J. Abca1/apoe/hdl pathway mediates gw3965-induced neurorestoration after stroke Stroke 2016;PMID: 28028143. Full text

Ding G, Chen J, Chopp M, Li L, Yan T, Li Q, Cui C, Davarani SP, and Jiang Q. Cell treatment for stroke in type two diabetic rats improves vascular permeability measured by MRI PLoS One 2016; 11(2):e0149147. PMID: 26900843. Full Text

Ekanger LA, Mills DR, Ali MM, Polin LA, Shen Y, Haacke EM, and Allen MJ. Spectroscopic characterization of the 3+ and 2+ oxidation states of europium in a macrocyclic tetraglycinate complex Inorg Chem 2016;PMID: 27244124. Article Request Form

Elmghirbi R, Nagaraja TN, Brown SL, Panda S, Aryal MP, Keenan KA, Bagher-Ebadian H, Cabral G, and Ewing JR. Acute temporal changes of mri-tracked tumor vascular parameters after combined anti-angiogenic and radiation treatments in a rat glioma model: Identifying signatures of synergism Radiat Res 2016;PMID: 28001908. Full text

Espay AJ, LeWitt PA, Hauser RA, Merola A, Masellis M, and Lang AE. Neurogenic orthostatic hypotension and supine hypertension in Parkinson's disease and related synucleinopathies: prioritisation of treatment targets Lancet Neurol 2016; 15(9):954-966. PMID: 27478953. Full Text

Gamage NH, Jing L, Worsham MJ, and Ali MM. Targeted theranostic approach for glioma using dendrimer-based curcumin nanoparticle J Nanomed Nanotechnol 2016; 7(4)PMID: 27699139. Full Text

Greer DM, Varelas PN, and Wijdicks EF. American academy of neurology guidelines and the neurologic determination of death-reply JAMA Neurol 2016;PMID: 27065178. Full Text

Gulyani S, Salas R, Mari Z, Choi S, Mahajan A, and Gamaldo C. Evaluating and managing sleep disorders in the parkinson's disease clinic Basal Ganglia 2016; 6(3):165-172. PMID: 27818912. Article Request Form

Hacein-Bey L, Varelas PN, Ulmer JL, Mark LP, Raghavan K, and Provenzale JM. Imaging of cerebrovascular disease in pregnancy and the puerperium AJR Am J Roentgenol 2016; 206(1):26-38. PMID: 26491895. Full Text

Hampson NB, Kieburtz KD, LeWitt PA, Leinonen M, and Freed MI. Prospective evaluation of pulmonary function in parkinson's disease patients with motor fluctuations (12 of 25 words) Int J Neurosci 2016:1-20. PMID: 27345931. Article Request Form

81 Harms PW, Hocker TL, Zhao L, Chan MP, Andea AA, Wang M, Harms KL, Wang ML, Carskadon S, Palanisamy N, and Fullen DR. Loss of p16 expression and copy number changes of CDKN2A in a spectrum of spitzoid melanocytic lesions Hum Pathol 2016;PMID: 27569296. Full Text

Hijaz M, Das S, Mert I, Gupta A, Al-Wahab Z, Tebbe C, Dar S, Chhina J, Giri S, Munkarah A, Seal S, and Rattan R. Folic acid tagged nanoceria as a novel therapeutic agent in ovarian cancer BMC Cancer 2016; 16(1):220. PMID: 26979107. Full Text

Jia L, Wang L, Chopp M, Zhang Y, Szalad A, and Zhang ZG. MicroRNA 146a locally mediates distal axonal growth of dorsal root ganglia neurons under high glucose and sildenafil conditions Neuroscience 2016; 329:43-53. PMID: 27167084. Full Text

Jiang Q. Magnetic resonance imaging and cell-based neurorestorative therapy after brain injury Neural Regen Res 2016; 11(1):7-14. PMID: 26981068. Full Text

Jiang Q, Zhang L, Ding G, Davoodi-Bojd E, Li Q, Li L, Sadry N, Nedergaard M, Chopp M, and Zhang Z. Impairment of the glymphatic system after diabetes J Cereb Blood Flow Metab 2016;PMID: 27306755. Full Text

Karki K, Ewing JR, and Ali MM. Targeting glioma with a dual mode optical and paramagnetic nanoprobe across the blood-brain tumor barrier J Nanomed Nanotechnol 2016; 7(4)PMID: 27695645. Full Text

Kassis H, Shehadah A, Li C, Zhang Y, Cui Y, Roberts C, Sadry N, Liu X, Chopp M, and Zhang ZG. Class IIa histone deacetylases affect neuronal remodeling and functional outcome after stroke Neurochem Int 2016; 96:24-31. PMID: 27103167. Article Request Form

Katakowski M, and Chopp M. Exosomes as tools to suppress primary brain tumor Cell Mol Neurobiol 2016;PMID: 26983831. Full Text.

Katakowski M, Charteris N, Chopp M, and Khain E. Density-dependent regulation of glioma cell proliferation and invasion mediated by miR-9 Cancer Microenviron 2016;PMID: 27975329. Full text

Knight R, Nagaraja T, Li L, Jiang Q, Tundo K, Chopp M, and Seyfried D. A prospective safety trial of atorvastatin treatment to assess rebleeding after spontaneous intracerebral hemorrhage: A serial MRI investigation Austin J Cerebrovasc Dis Stroke 2016; 3(1)PMID: Not assigned. Full text

Kokeny P, Cheng YC, Liu S, Xie H, and Jiang Q. Quantifications of in vivo labeled stem cells based on measurements of magnetic moments Magn Reson Imaging 2016;PMID: 27594530. Full Text

Krisciunas GP, Castellano K, McCulloch TM, Lazarus CL, Pauloski BR, Meyer TK, Graner D, Van Daele DJ, Silbergleit AK, Crujido LR, Rybin D, Doros G, Kotz T, and Langmore SE. Impact of compliance on dysphagia rehabilitation in head and neck cancer patients: Results from a multi- center clinical trial Dysphagia 2016;PMID: 27848021. Full Text

Kroll HR, Macaulay T, and Jesse M. A preliminary survey examining predictors of burnout in pain medicine physicians in the united states Pain Physician 2016; 19(5):E689-696. PMID: 27389112. Full Text

Kumar A, Giri S, and Kumar A. AICAR-mediated AMPK activation induces protective innate responses in bacterial endophthalmitis Cell Microbiol 2016;PMID: 27264993. Full Text

Lewis A, Varelas P, and Greer D. Controversies after brain death: When families ask for more Chest 2016; 149(2):607-608. PMID: 26867848. Full Text

Lewis A, Varelas P, and Greer D. Pregnancy and brain death: Lack of guidance in U.S. hospital policies Am J Perinatol 2016;PMID: 27159202. Article Request Form

Lewis A, Adams N, Varelas P, Greer D, and Caplan A. Organ support after death by neurologic criteria: Results of a survey of us neurologists Neurology 2016;PMID: 27449064. Full Text 82 LeWitt PA, Poewe W, Elmer LW, Asgharnejad M, Boroojerdi B, Grieger F, and Bauer L. The efficacy profile of rotigotine during the waking hours in patients with advanced parkinson's disease: A post hoc analysis Clin Neuropharmacol 2016;PMID: 26882318. Full Text

LeWitt PA, and Fahn S. Levodopa therapy for Parkinson disease: A look backward and forward Neurology 2016; 86(14 Suppl 1):S3-s12. PMID: 27044648. Full Text

LeWitt PA, Hauser RA, Grosset DG, Stocchi F, Saint-Hilaire MH, Ellenbogen A, Leinonen M, Hampson NB, DeFeo- Fraulini T, Freed MI, and Kieburtz KD. A randomized trial of inhaled levodopa (CVT-301) for motor fluctuations in Parkinson's disease Mov Disord 2016;PMID: 27090868. Full Text

Liu LJ, Brown SL, Ewing JR, Ala BD, Schneider KM, and Schlesinger M. Estimation of tumor interstitial fluid pressure (tifp) noninvasively PLoS One 2016; 11(7):e0140892. PMID: 27467886. Full Text

Li L, Chopp M, Ding G, Qu C, Nejad-Davarani SP, Davoodi-Bojd E, Li Q, Mahmood A, and Jiang Q. Diffusion- derived mri measures of longitudinal microstructural remodeling induced by marrow stromal cell therapy after TBI J Neurotrauma 2016;PMID: 26993214. Full Text

Liu XS, Chopp M, Pan WL, Wang XL, Fan BY, Zhang Y, Kassis H, Zhang RL, Zhang XM, and Zhang ZG. MicroRNA-146a promotes oligodendrogenesis in stroke Mol Neurobiol 2016;PMID: 26738853. Full Text

Liu XS, Fan BY, Pan WL, Li C, Levin AM, Wang X, Zhang RL, Zervos TM, Hu J, Zhang XM, Chopp M, and Zhang ZG. Identification of miRNomes associated with adult neurogenesis after stroke using Argonaute 2-based RNA sequencing RNA Biol 2016:0. PMID: 27315491. Article Request Form

Loeffler DA, LeWitt PA, and Camp DM. Nocardia asteroides-induced movement abnormalities in mice: Relevance for parkinson's disease? Mov Disord 2016;PMID: 27411508. Full Text

Loeffler DA, Klaver AC, Coffey MP, Aasly JO, and LeWitt PA. Age-related decrease in heat shock 70- kda protein 8 in cerebrospinal fluid is associated with increased oxidative stress Front Aging Neurosci 2016; 8:178. PMID: 27507943. Full Text

Loomba V, Kaveeshvar H, Upadhyay A, and Sibai N. Neuropathic pain in cancer patients: A brief review Indian J Cancer 2015; 52(3):425-428. PMID: 26905158. Full Text

Loomba V, Kaveeshvar H, and Dwivedi S. Paraplegia after thoracic epidural steroid injection A A Case Rep 2016;PMID: 27536909. Article Request Form

Mahajan A, Balakrishnan P, Patel A, Konstantinidis I, Nistal D, Annapureddy N, Poojary P, Nadkarni GN, and Sidiropoulos C. Epidemiology of inpatient stay in parkinson's disease in the united states: Insights from the nationwide inpatient sample J Clin Neurosci 2016;PMID: 27242063. Full Text

Mahajan A, Patel A, Nadkarni G, and Sidiropoulos C. Are hospitalized Parkinson's disease patients more likely to carry a do-not-resuscitate order? J Clin Neurosci 2016;PMID: 27810417. Full Text

Mahajan A, Constantinou J, and Sidiropoulos C. ECHS1 deficiency-associated paroxysmal exercise-induced dyskinesias: case presentation and initial benefit of intervention J Neurol 2016;PMID: 28039521. Full text

Mangalam AK, Rattan R, Suhail H, Singh J, Hoda MN, Deshpande M, Fulzele S, Denic A, Shridhar V, Kumar A, Viollet B, Rodriguez M, and Giri S. AMP-activated protein kinase suppresses autoimmune central nervous system disease by regulating m1-type macrophage-th17 axis J Immunol 2016;PMID: 27354217. Full Text

Marrotte EJ, Mitsias P, Melvin L, Mahmood A, Tsivgoulis G, and Varelas P. Real-time detection of cerebral artery rebleeding by transcranial doppler ultrasound: Hemodynamic changes and response to treatment J Clin Neurol 2016;PMID: 27868398. Full Text

83 Mestre TA, Sidiropoulos C, Hamani C, Poon YY, Lozano AM, Lang AE, and Moro E. Long-term double-blinded unilateral pedunculopontine area stimulation in Parkinson's disease Mov Disord 2016;PMID: 27392513. Full Text

Miller DJ, Shah K, Modi S, Mahajan A, Zahoor S, and Affan M. The evolution and application of cardiac monitoring for occult atrial fibrillation in cryptogenic stroke and TIA Curr Treat Options Neurol 2016; 18(4):17. PMID: 26923607. Full Text

Modi SY, Dharaiya D, Katramados AM, and Mitsias P. Predictors of prolonged hospital stay in status migrainosus Neurohospitalist 2016; 6(4):141-146. PMID: 27695594. Full Text

Munkarah A, Mert I, Chhina J, Hamid S, Poisson L, Hensley-Alford S, Giri S, and Rattan R. Targeting of free fatty acid receptor 1 in EOC: A novel strategy to restrict the adipocyte-EOC dependence Gynecol Oncol 2016; 141(1):72-79. PMID: 27016232. Full Text

Nazem-Zadeh MR, Bowyer SM, Moran JE, Davoodi-Bojd E, Zillgitt A, Weiland BJ, Bagher- Ebadian H, Mahmoudi F, Elisevich K, and Soltanian-Zadeh H. MEG Coherence and DTI Connectivity in mTLE Brain Topogr 2016;PMID: 27060092. Full Text

Nazem-Zadeh MR, Elisevich K, Air EL, Schwalb JM, Divine G, Kaur M, Wasade VS, Mahmoudi F, Shokri S, Bagher-Ebadian H, and Soltanian-Zadeh H. DTI-based response-driven modeling of mTLE laterality Neuroimage Clin 2016; 11:694-706. PMID: 27330966. Full Text

Patel AA, Mahajan A, Benjo A, Jani VB, Annapureddy N, Agarwal SK, Simoes PK, Pakanati KC, Sinha V, Konstantinidis I, Pathak A, and Nadkarni GN. A national perspective of do-not-resuscitate order utilization predictors in intracerebral hemorrhage Neurohospitalist 2016; 6(1):7-10. PMID: 26753051. Full Text

Patel AA, Mahajan A, Benjo A, Pathak A, Kar J, Jani VB, Annapureddy N, Agarwal SK, Sabharwal MS, Simoes PK, Konstantinidis I, Yacoub R, Javed F, El Hayek G, Menon MC, and Nadkarni GN. A nationwide analysis of outcomes of weekend admissions for intracerebral hemorrhage shows disparities based on hospital teaching status Neurohospitalist 2016; 6(2):51-58. PMID: 27053981. Full Text

Patel N. Review of medication-induced movement disorders JAMA Neurol 2016; 73(8):1034. PMID: 27533355. Full Text

Qian JY, Chopp M, and Liu Z. Mesenchymal stromal cells promote axonal outgrowth alone and synergistically with astrocytes via tpa PLoS One 2016; 11(12):e0168345. PMID: 27959956. Full text

Romero C, Monu S, Cabral G, Knight R, and Carretero O. OS 21-02 Connecting tubule-glomerular feedback (ctgf) in renal hemodynamics and blood pressure regulation after unilateral nephrectomy (unx) J Hypertens 2016; 34 Suppl 1:e235. PMID: 27643022. Full Text

Samudra N, Patel N, Womack KB, Khemani P, and Chitnis S. Psychosis in parkinson disease: A review of etiology, phenomenology, and management Drugs Aging 2016; 33(12):855-863. PMID: 27830568. Article Request Form

Shah K, and Miller DJ. Three-dimensional modeling of Eagle syndrome Neurology 2016; 87(21):2279-2280. PMID: 27872222. Full Text

Shankar A, Borin TF, Iskander A, Varma NR, Achyut BR, Jain M, Mikkelsen T, Guo AM, Chwang WB, Ewing JR, Bagher-Ebadian H, and Arbab AS. Combination of vatalanib and a 20-HETE synthesis inhibitor results in decreased tumor growth in an animal model of human glioma Onco Targets Ther 2016; 9:1205-1219. PMID: 27022280. Full Text

Shvarts V, Zoltay G, Bowyer SM, Zillgitt A, Moran JE, Mason RK, Tepley N, and Burdette D. Periodic discharges: Insight from magnetoencephalography J Clin Neurophysiol 2016;PMID: 27832046. Full Text

84 Sidiropoulos C, Rammo R, Merker B, Mahajan A, LeWitt P, Kaminski P, Womble M, Zec A, Taylor D, Wall J, and Schwalb JM. Intraoperative MRI for deep brain stimulation lead placement in Parkinson's disease: 1 year motor and neuropsychological outcomes J Neurol 2016; 263(6):1226- 1231. PMID: 27126457. Full Text

Singh J, Olle B, Suhail H, Felicella MM, and Giri S. Metformin-induced mitochondrial function and ABCD2 up regulation in X-linked adrenoleukodystrophy involves AMP activated protein kinase J Neurochem 2016;PMID: 26849413. Article Request Form

Singh J, Deshpande M, Suhail H, Rattan R, and Giri S. Targeted stage-specific inflammatory microrna profiling in urine during disease progression in experimental autoimmune encephalomyelitis: Markers of disease progression and drug response J Neuroimmune Pharmacol 2016; 11(1):84-97. PMID: 26277791. Full Text

Sood A, Williamson SR, and Leavitt DA. Neuroendocrine tumor of the ureter: A zebra among horses J Endourol Case Rep 2016; 2(1):204-208. PMID: 27868098. Full Text

Tsivgoulis G, Katsanos AH, Magoufis G, Kargiotis O, Papadimitropoulos G, Vadikolias K, Karapanayiotides T, Ellul J, Alexandrov AW, Mitsias PD, and Alexandrov AV. Percutaneous transluminal angioplasty and stenting for symptomatic intracranial arterial stenosis: a systematic review and meta-analysis Ther Adv Neurol Disord 2016; 9(5):351-358. PMID: 27582890. Full Text

Varelas PN, and Lewis A. Modern approach to brain death Semin Neurol 2016; 36(6):625- 630. PMID: 27907967. Article Request Form

Venkat P, Chopp M, and Chen J. Models and mechanisms of vascular dementia Exp Neurol 2015; 272:97-108. PMID: 25987538. Full Text

Venkat P, Chopp M, and Chen J. New insights into coupling and uncoupling of cerebral blood flow and metabolism in the brain Croat Med J 2016; 57(3):223-228. PMID: 27374823. Full Text

Venkat P, Chopp M, Zacharek A, Cui C, Zhang L, Li Q, Lu M, Zhang T, Liu A, and Chen J. White matter damage and glymphatic dysfunction in a model of vascular dementia in rats with no prior vascular pathologies Neurobiol Aging 2017; 50:96-106. PMID: 27940353. Full text

Vithanarachchi SM, Foley CD, Trimpin S, Ewing JR, Ali MM, and Allen MJ. Myelin-targeted, texaphyrin-based multimodal imaging agent for magnetic resonance and optical imaging Contrast Media Mol Imaging 2016;PMID: 27596704. Full Text

Wang D, Li T, Wei H, Wang Y, Yang G, Tian Y, Zhao Z, Wang L, Yu S, Zhang Y, Chen J, Jiang R, and Zhang JN. Atorvastatin enhances angiogenesis to reduce subdural hematoma in a rat model J Neurol Sci 2016; 362:91-99. PMID: 26944125. Full Text

Walbert T, Glantz M, Schultz L, and Puduvalli VK. Impact of provider level, training and gender on the utilization of palliative care and hospice in neuro-oncology: a North-American survey J Neurooncol 2016; 126(2):337-345. PMID: 26518539. Full Text

Wang L, Chopp M, Jia L, Lu X, Szalad A, Zhang Y, Zhang R, and Zhang ZG. Therapeutic benefit of extended thymosin beta4 treatment is independent of blood glucose level in mice with diabetic peripheral neuropathy J Diabetes Res 2015; 2015:173656. PMID: 25945352. Full Text

Wang L, Chopp M, Szalad A, Lu X, Jia L, Lu M, Zhang RL, and Zhang ZG. Tadalafil promotes the recovery of peripheral neuropathy in type II diabetic mice PLoS One 2016; 11(7):e0159665. PMID: 27438594. Full Text

Wasade VS, Balki I, Bowyer SM, Gaddam S, Mohammadi-Nejad AR, Nazem-Zadeh MR, Soltanian-Zadeh H, Zillgitt A, and Spanaki-Varelas M. Controllable yawning expressed as focal seizures of frontal lobe epilepsy Epilepsy Behav Case Rep 2016; 6:61-63. PMID: 27668178. Full Text

Yan T, Venkat P, Chopp M, Zacharek A, Ning R, Roberts C, Zhang Y, Lu M, and Chen J.

85 Neurorestorative responses to delayed human mesenchymal stromal cells treatment of stroke in type 2 diabetic rats Stroke 2016; 47(11):2850-2858. PMID: 27729575. Full Text

Ye R, Shi M, Liu Q, and Chen J. Redox imbalance and stroke Oxid Med Cell Longev 2016; 2016:3065263. PMID: 27516831. Full Text

Yu P, Zhang Z, Li S, Wen X, Quan W, Tian Q, Chen J, Zhang J, and Jiang R. Progesterone modulates endothelial progenitor cell (EPC) viability through the CXCL12/CXCR4/PI3K/Akt signalling pathway Cell Prolif 2016;PMID: 26818151. Article Request Form

Yu X, Xu X, Jackson A, Sun J, Huang P, Mao Y, Chen Z, Lou M, Jiang Q, and Zhang M. Blood brain barrier disruption in diabetic stroke related to unfavorable outcome Cerebrovasc Dis 2016; 42(1-2):49- 56. PMID: 26986824. Article Request Form

Yu X, Yuan L, Jackson A, Sun J, Huang P, Xu X, Mao Y, Lou M, Jiang Q, and Zhang M. Prominence of medullary veins on susceptibility-weighted images provides prognostic information in patients with subacute stroke AJNR Am J Neuroradiol 2016; 37(3):423-429. PMID: 26514606. Full Text

Yu X, Song R, Jiaerken Y, Yuan L, Huang P, Lou M, Jiang Q, and Zhang M. White matter injury induced by diabetes in acute stroke is clinically relevant: A preliminary study Diab Vasc Dis Res 2017; 14(1):40-46. PMID: 27941055. Full text

Yuan L, Yu X, Zhang M, Jiang Q, and P. Du Y. Correction of t1 effects in calculation of relative recirculation in ischemic stroke patients Journal of Medical and Biological Engineering 2016; 36(5):740-750. PMID: Not assigned. Article Request Form

Zhang J, Zhang ZG, Li Y, Lu M, Zhang Y, Elias SB, and Chopp M. Thymosin beta4 promotes oligodendrogenesis in the demyelinating central nervous system Neurobiol Dis 2016; 88:85-95. PMID: 26805386. Full Text

Zhang L, Chopp M, Lu M, Zhang T, Winter S, Doppler E, Meier D, Chao L, Eapen A, Pabla P, and Gang Zhang Z. Cerebrolysin dose-dependently improves neurological outcome in rats after acute stroke: A prospective, randomized, blinded, and placebo-controlled study Int J Stroke 2016;PMID: 26763925. Article Request Form

Zhang L, Chopp M, Zhang Y, Xiong Y, Li C, Sadry N, Rhaleb I, Lu M, and Zhang ZG. Diabetes mellitus impairs cognitive function in middle-aged rats and neurological recovery in middle-aged rats after stroke Stroke 2016; 47(8):2112-2118. PMID: 27387991. Full Text

Zhang L, Varma NR, Gang ZZ, Ewing JR, Arbab AS, and Ali MM. Targeting triple negative breast cancer with a small-sized paramagnetic nanoparticle J Nanomed Nanotechnol 2016; 7(5)PMID: 28018751. Full text

Zhang R, Zhang Z, and Chopp M. Function of neural stem cells in ischemic brain repair processes J Cereb Blood Flow Metab 2016;PMID: 27742890. Full Text

Zhang Y, Chopp M, Liu XS, Katakowski M, Wang X, Tian X, Wu D, and Zhang ZG. Exosomes derived from mesenchymal stromal cells promote axonal growth of cortical neurons Mol Neurobiol 2016;PMID: 26993303. Full Text

Zhang Y, Zhang ZG, Chopp M, Meng Y, Zhang L, Mahmood A, and Xiong Y. Treatment of traumatic brain injury in rats with N-acetyl-seryl-aspartyl-lysyl-proline J Neurosurg 2016:1-14. PMID: 27203137. Full Text

Zhang Y, Chopp M, Zhang ZG, Katakowski M, Xin H, Qu C, Ali M, Mahmood A, and Xiong Y. Systemic administration of cell-free exosomes generated by human bone marrow derived mesenchymal stem cells cultured under 2D and 3D conditions improves functional recovery in rats after traumatic brain injury Neurochem Int 2016;PMID: 27539657. Article Request Form

Zhang Z, and Chopp M. Neural stem cells and ischemic bra J Stroke 2016;PMID: 27488979. Full Text

86 Zhang ZG, and Chopp M. Exosomes in stroke pathogenesis and therapy J Clin Invest 2016; 126(4):1190-1197. PMID: 27035810. Article Request Form

87 NEUROSURGERY

Alentorn A, Hoang-Xuan K, and Mikkelsen T. Presenting signs and symptoms in brain tumors Handb Clin Neurol 2016; 134:19-26. PMID: 26948346. Article Request Form

Ali R, Khan M, Chang V, Narang J, Jain R, Marin H, Rock J, and Kole M. MRI pre- and post- embolization enhancement patterns predict surgical outcomes in intracranial meningiomas J Neuroimaging 2016; 26(1):130-135. PMID: 25996574. Article Request Form

Ali R, Schwalb JM, Nerenz DR, Antoine HJ, and Rubinfeld I. Use of the modified frailty index to predict 30-day morbidity and mortality from spine surgery J Neurosurg Spine 2016:1-5. PMID: 27153143. Full Text

Ali R. Ictal cardiac ryhthym abnormalities Open Cardiovasc Med J 2016; 10:105-109. PMID: 27347227. Full Text

Broadbent B, Tseng J, Kast R, Noh T, Brusatori M, Kalkanis SN, and Auner GW. Shining light on neurosurgery diagnostics using Raman spectroscopy J Neurooncol 2016; 130(1):1-9. PMID: 27522510. Full Text

Burgett ME, Lathia JD, Roth P, Nowacki AS, Galileo DS, Pugacheva E, Huang P, Vasanji A, Li M, Byzova T, Mikkelsen T, Bao S, Rich JN, Weller M, and Gladson CL. Direct contact with perivascular tumor cells enhances integrin alphavbeta3 signaling and migration of endothelial cells Oncotarget 2016;PMID: 27270311. Full Text

Bydon M, Macki M, Kerezoudis P, Sciubba DM, Wolinsky JP, Witham TF, Gokaslan ZL, and Bydon A. The incidence of adjacent segment disease after lumbar discectomy: A study of 751 patients J Clin Neurosci 2016;PMID: 27765560. Full Text

Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA, Morozova O, Newton Y, Radenbaugh A, Pagnotta SM, Anjum S, Wang J, Manyam G, Zoppoli P, Ling S, Rao AA, Grifford M, Cherniack AD, Zhang H, Poisson L, Carlotti CG, Jr., Tirapelli DP, Rao A, Mikkelsen T, Lau CC, Yung WK, Rabadan R, Huse J, Brat DJ, Lehman NL, Barnholtz-Sloan JS, Zheng S, Hess K, Rao G, Meyerson M, Beroukhim R, Cooper L, Akbani R, Wrensch M, Haussler D, Aldape KD, Laird PW, Gutmann DH, Noushmehr H, Iavarone A, and Verhaak RG. Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma Cell 2016; 164(3):550-563. PMID: 26824661. Article Request Form

Cloughesy TF, Landolfi J, Hogan DJ, Bloomfield S, Carter B, Chen CC, Elder JB, Kalkanis SN, Kesari S, Lai A, Lee IY, Liau LM, Mikkelsen T, Nghiemphu PL, Piccioni D, Walbert T, Chu A, Das A, Diago OR, Gammon D, Gruber HE, Hanna M, Jolly DJ, Kasahara N, McCarthy D, Mitchell L, Ostertag D, Robbins JM, Rodriguez-Aguirre M, and Vogelbaum MA. Phase 1 trial of vocimagene amiretrorepvec and 5- fluorocytosine for recurrent high-grade glioma Sci Transl Med 2016; 8(341):341ra375. PMID: 27252174. Article Request Form

Cloughesy T, Finocchiaro G, Belda-Iniesta C, Recht L, Brandes AA, Pineda E, Mikkelsen T, Chinot OL, Balana C, Macdonald DR, Westphal M, Hopkins K, Weller M, Bais C, Sandmann T, Bruey JM, Koeppen H, Liu B, Verret W, Phan SC, and Shames DS. Randomized, double-blind, placebo- controlled, multicenter phase II study of onartuzumab plus bevacizumab versus placebo plus bevacizumab in patients with recurrent glioblastoma: Efficacy, safety, and hepatocyte growth factor and o6-methylguanine-DNA methyltransferase biomarker analyses J Clin Oncol 2016:Jco2015647685. PMID: 27918718. Full text

Dewan MC, Thompson RC, Kalkanis SN, Barker FG, 2nd, and Hadjipanayis CG. Prophylactic antiepileptic drug administration following brain tumor resection: results of a recent AANS/CNS Section on Tumors survey JNeurosurg 2016:1-7. PMID: 27341048. Full Text

88 Elmghirbi R, Nagaraja TN, Brown SL, Panda S, Aryal MP, Keenan KA, Bagher-Ebadian H, Cabral G, and Ewing JR. Acute temporal changes of mri-tracked tumor vascular parameters after combined anti-angiogenic and radiation treatments in a rat glioma model: Identifying signatures of synergism Radiat Res 2016;PMID: 28001908. Full text

Gilbert MR, Pugh SL, Aldape K, Sorensen AG, Mikkelsen T, Penas-Prado M, Bokstein F, Kwok Y, Lee RJ, and Mehta M. NRG oncology RTOG 0625: a randomized phase II trial of bevacizumab with either irinotecan or dose- dense temozolomide in recurrent glioblastoma J Neurooncol 2016;PMID: 27770279. Full Text

Hacein-Bey L, Varelas PN, Ulmer JL, Mark LP, Raghavan K, and Provenzale JM. Imaging of cerebrovascular disease in pregnancy and the puerperium AJR Am J Roentgenol 2016; 206(1):26-38. PMID: 26491895. Full Text

Hodges TR, Ferguson SD, Caruso HG, Kohanbash G, Zhou S, Cloughesy TF, Berger MS, Poste GH, Khasraw M, Ba S, Jiang T, Mikkelson T, Yung WK, de Groot JF, Fine H, Cantley LC, Mellinghoff IK, Mitchell DA, Okada H, and Heimberger AB. Prioritization schema for immunotherapy clinical trials in glioblastoma Oncoimmunology 2016; 5(6):e1145332. PMID: 27471611. Article Request Form

Hong X, Meng Y, and Kalkanis SN. Serum proteins are extracted along with monolayer cells in plasticware and interfere with protein analysis J Biol Methods 2016; 3(4)PMID: 27631018. Full Text

Jiang W, Finniss S, Cazacu S, Xiang C, Brodie Z, Mikkelsen T, Poisson L, Shackelford DB, and Brodie C. Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma Oncotarget 2016;PMID: 27486821. Full Text

John JK, Robin AM, Pabaney AH, Rammo RA, Schultz LR, Sadry NS, and Lee IY. Complications of ventricular entry during craniotomy for brain tumor resection J Neurosurg 2016:1-7. PMID: 27813467. Full Text

Kazimirsky G, Jiang W, Slavin S, Ziv-Av A, and Brodie C. Mesenchymal stem cells enhance the oncolytic effect of Newcastle disease virus in glioma cells and glioma stem cells via the secretion of TRAIL Stem Cell Res Ther 2016; 7(1):149. PMID: 27724977. Full Text

Knight R, Nagaraja T, Li L, Jiang Q, Tundo K, Chopp M, and Seyfried D. A prospective safety trial of atorvastatin treatment to assess rebleeding after spontaneous intracerebral hemorrhage: A serial MRI investigation Austin J Cerebrovasc Dis Stroke 2016; 3(1)PMID: Not assigned. Full text

Lee I, Kalkanis S, and Hadjipanayis CG. Stereotactic laser interstitial thermal therapy for recurrent high-grade gliomas Neurosurgery 2016; 79 Suppl 1:S24-s34. PMID: 27861323. Full Text

Lewis A, Varelas P, and Greer D. Controversies after brain death: When families ask for more Chest 2016; 149(2):607-608. PMID: 26867848. Full Text

Lewis A, Varelas P, and Greer D. Pregnancy and brain death: Lack of guidance in U.S. hospital policies Am J Perinatol 2016;PMID: 27159202. Article Request Form

Li L, Chopp M, Ding G, Qu C, Nejad-Davarani SP, Davoodi-Bojd E, Li Q, Mahmood A, and Jiang Q. Diffusion- derived mri measures of longitudinal microstructural remodeling induced by marrow stromal cell therapy after TBI J Neurotrauma 2016;PMID: 26993214. Full Text

Li M, Jia Q, Chen T, Zhao Z, Chen J, and Zhang J. The role of vascular endothelial growth factor and vascular endothelial growth inhibitor in clinical outcome of traumatic brain injury Clin Neurol Neurosurg 2016; 144:7-13. PMID: 26945876. Full Text

Lim S, Carabini LM, Kim RD, Khanna R, Dahdaleh NS, and Smith ZA. Evaluation of ASA classification as thirty-day morbidity predictor after single-level elective anterior cervical discectomy and fusion Spine J 2016;PMID: 27669670. Full Text

89 Lownie SP, Larrazabal R, and Kole MK. Circle of willis collateral during temporary internal carotid artery occlusion i: Observations from digital subtraction angiography Can J Neurol Sci 2016; 43(4):533-537. PMID: 27030296. Article Request Form

Macki M, Syeda S, Kerezoudis P, Gokaslan ZL, Bydon A, and Bydon M. Preoperative motor strength and time to surgery are the most important predictors of improvement in foot drop due to degenerative lumbar disease J Neurol Sci 2016; 361:133-136. PMID: 26810531. Full Text

Macki M, Syeda S, Kerezoudis P, Bydon A, Witham TF, Sciubba DM, Wolinsky JP, Bydon M, and Gokaslan Z. rhBMP-2 protects against reoperation for pseudoarthrosis and/or instrumentation failure: A matched case-control study of 448 patients J Clin Neurosci 2016;PMID: 27396376. Full Text

Macki M, Syeda S, Rajjoub K, Kerezoudis P, Bydon A, Wolinsky JP, Witham T, Sciubba DM, Bydon M, and Gokaslan Z. The effect of smoking status on successful arthrodesis after lumbar instrumentation supplemented with rhBMP-2 World Neurosurg 2016;PMID: 27756663. Full Text

Macki M, and Dabaja AA. Literature review of vaccine-related adverse events reported from HPV vaccination in randomized controlled trials Basic Clin Androl 2016; 26:16. PMID: 27895921. Full Text

Marrotte EJ, Mitsias P, Melvin L, Mahmood A, Tsivgoulis G, and Varelas P. Real-time detection of cerebral artery rebleeding by transcranial doppler ultrasound: Hemodynamic changes and response to treatment J Clin Neurol 2016;PMID: 27868398. Full Text

Meir R, Betzer O, Motiei M, Kronfeld N, Brodie C, and Popovtzer R. Design principles for noninvasive, longitudinal and quantitative cell tracking with nanoparticle-based CT imaging Nanomedicine 2016;PMID: 27720990. Full Text

Montalvo M, Ali R, Silver B, and Khan M. Long-term arrhythmia monitoring in cryptogenic stroke: Who, how, and for how long? Open Cardiovasc Med J 2016; 10:89-93. PMID: 27347225. Full Text

Nazem-Zadeh MR, Elisevich K, Air EL, Schwalb JM, Divine G, Kaur M, Wasade VS, Mahmoudi F, Shokri S, Bagher-Ebadian H, and Soltanian-Zadeh H. DTI-based response-driven modeling of mTLE laterality Neuroimage Clin 2016; 11:694-706. PMID: 27330966. Full Text

Noh T, and Chedid MK. A novel technique to repair a transverse sacral fracture in a previously fused lumbosacral spondylolisthesis Surg Neurol Int 2016; 7(Suppl 38):S914-s916. PMID: 28028448. Full text

Pabaney AH, Robin AM, Basheer A, and Malik GM. Surgical management of dural arteriovenous fistula after craniotomy: Case report and review of literature World Neurosurg 2016;PMID: 26844878. Full Text

Pabaney AH, Ali R, Kole M, and Malik GM. Arteriovenous malformations of the corpus callosum: Pooled analysis and systematic review of literature Surg Neurol Int 2016; 7(Suppl 9):S228-236. PMID: 27127713. Full Text

Pabaney AH, Rammo RA, Tahir RA, and Seyfried D. Development of a de novo AVM following ischemic stroke: Case report and review of the current literature World Neurosurg 2016;PMID: 27671884. Full Text

Parajuli P, Anand R, Mandalaparty C, Suryadevara R, Sriranga PU, Michelhaugh SK, Cazacu S, Finniss S, Thakur A, Lum LG, Schalk D, Brodie C, and Mittal S. Preferential expression of functional IL- 17R in glioma stem cells: potential role in self-renewal Oncotarget 2016;PMID: 26755664. Full Text

Ramaswamy V, Hielscher T, Mack SC, Lassaletta A, Lin T, Pajtler KW, Jones DT, Luu B, Cavalli FM, Aldape K, Remke M, Mynarek M, Rutkowski S, Gururangan S, McLendon RE, Lipp ES, Dunham C, Hukin J, Eisenstat DD, Fulton D, van Landeghem FK, Santi M, van Veelen MC, Van Meir EG, Osuka S, Fan X, Muraszko KM, Tirapelli DP, Oba-Shinjo SM, Marie SK, Carlotti CG, Lee JY, Nageswara Rao AA, 90 Giannini C, Faria CC, Nunes S, Mora J, Hamilton RL, Hauser P, Jabado N, Petrecca K, Jung S, Massimi L, Zollo M, Cinalli G, Bognar L, Klekner A, Hortobagyi T, Leary S, Ermoian RP, Olson JM, Leonard JR, Gardner C, Grajkowska WA, Chambless LB, Cain J, Eberhart CG, Ahsan S, Massimino M, Giangaspero F, Buttarelli FR, Packer RJ, Emery L, Yong WH, Soto H, Liau LM, Everson R, Grossbach A, Shalaby T, Grotzer M, Karajannis MA, Zagzag D, Wheeler H, von Hoff K, Alonso MM, Tunon T, Schuller U, Zitterbart K, Sterba J, Chan JA, Guzman M, Elbabaa SK, Colman H, Dhall G, Fisher PG, Fouladi M, Gajjar A, Goldman S, Hwang E, Kool M, Ladha H, Vera-Bolanos E, Wani K, Lieberman F, Mikkelsen T, Omuro AM, Pollack IF, Prados M, Robins HI, Soffietti R, Wu J, Metellus P, Tabori U, Bartels U, Bouffet E, Hawkins CE, Rutka JT, Dirks P, Pfister SM, Merchant TE, Gilbert MR, Armstrong TS, Korshunov A, Ellison DW, and Taylor MD. Therapeutic impact of cytoreductive surgery and irradiation of posterior fossa ependymoma in the molecular era: A retrospective multicohort analysis J Clin Oncol 2016;PMID: 27269943. Full Text

Reinard KA, Zakaria HM, Qatanani A, Lee IY, Rock JP, and Houin HP. Preoperative external tissue expansion for complex cranial reconstructions J Neurosurg 2016:1-8. PMID: 26722853. Full Text

Reinard K, Nerenz DR, Basheer A, Tahir R, Jelsema T, Schultz L, Malik G, Air EL, and Schwalb JM. Racial disparities in the diagnosis and management of trigeminal neuralgia J Neurosurg 2016:1-7. PMID: 26967783. Full Text

Reinard KA, Cook DM, Zakaria HM, Basheer AM, Chang VW, and Abdulhak MM. A cohort study of the morbidity of combined anterior-posterior cervical spinal fusions: incidence and predictors of postoperative dysphagia Eur Spine J 2016;PMID: 26972082. Full Text

Schiff D, Desjardins A, Cloughesy T, Mikkelsen T, Glantz M, Chamberlain MC, Reardon DA, and Wen PY. Phase 1 dose escalation trial of the safety and pharmacokinetics of cabozantinib concurrent with temozolomide and radiotherapy or temozolomide after radiotherapy in newly diagnosed patients with high-grade gliomas Cancer 2016; 122(4):582-587. PMID: 26588662. Full Text

Shainer R, Almogi-Hazan O, Berger A, Hinden L, Mueller M, Brodie C, Simillion C, Paidas M, Barnea ER, and Or R. PreImplantation factor (PIF) therapy provides comprehensive protection against radiation induced pathologies Oncotarget 2016;PMID: 27449294. Full Text

Shankar A, Borin TF, Iskander A, Varma NR, Achyut BR, Jain M, Mikkelsen T, Guo AM, Chwang WB, Ewing JR, Bagher-Ebadian H, and Arbab AS. Combination of vatalanib and a 20-HETE synthesis inhibitor results in decreased tumor growth in an animal model of human glioma Onco Targets Ther 2016; 9:1205-1219. PMID: 27022280. Full Text

Sidiropoulos C, Rammo R, Merker B, Mahajan A, LeWitt P, Kaminski P, Womble M, Zec A, Taylor D, Wall J, and Schwalb JM. Intraoperative MRI for deep brain stimulation lead placement in Parkinson's disease: 1 year motor and neuropsychological outcomes J Neurol 2016; 263(6):1226- 1231. PMID: 27126457. Full Text

Sturm D, Orr BA, Toprak UH, Hovestadt V, Jones DT, Capper D, Sill M, Buchhalter I, Northcott PA, Leis I, Ryzhova M, Koelsche C, Pfaff E, Allen SJ, Balasubramanian G, Worst BC, Pajtler KW, Brabetz S, Johann PD, Sahm F, Reimand J, Mackay A, Carvalho DM, Remke M, Phillips JJ, Perry A, Cowdrey C, Drissi R, Fouladi M, Giangaspero F, Lastowska M, Grajkowska W, Scheurlen W, Pietsch T, Hagel C, GojoJ, Lotsch D, Berger W, Slavc I, Haberler C, Jouvet A, Holm S, Hofer S, Prinz M, Keohane C, Fried I, Mawrin C, Scheie D, Mobley BC, Schniederjan MJ, Santi M, Buccoliero AM, Dahiya S, Kramm CM, von Bueren AO, von Hoff K, Rutkowski S, Herold-Mende C, Fruhwald MC, Milde T, Hasselblatt M, Wesseling P, Rossler J, Schuller U, Ebinger M, Schittenhelm J, Frank S, Grobholz R, Vajtai I, Hans V, Schneppenheim R, Zitterbart K, Collins VP, Aronica E, Varlet P, Puget S, Dufour C, Grill J, Figarella- Branger D, Wolter M,Schuhmann MU, Shalaby T, Grotzer M, van Meter T, Monoranu CM, Felsberg J, Reifenberger G, Snuderl M, Forrester LA, Koster J, Versteeg R, Volckmann R, van Sluis P, Wolf S, Mikkelsen T, Gajjar A, Aldape K, Moore AS, Taylor MD, Jones C, Jabado N, Karajannis MA, Eils R, Schlesner M, Lichter P, von Deimling A, Pfister SM, Ellison DW, Korshunov A, and Kool M. New brain tumor entities emerge from molecular classification of CNS-PNETs Cell 2016; 164(5):1060-1072. PMID: 26919435. Article Request Form

91 Tahir RA, and Pabaney AH. Therapeutic hypothermia and ischemic stroke: A literature review Surg Neurol Int 2016; 7(Suppl 14):S381-386. PMID: 27313963. Full Text

Tahir RA, Asmaro K, Pabaney A, Kole M, Nypaver T, and Marin H. Separate origins of the left internal and external carotid arteries from the aortic arch and cervical internal carotid artery aneurysm in a patient with Noonan syndrome J Neurointerv Surg 2016;PMID: 27466463. Full Text

Walbert T, Glantz M, Schultz L, and Puduvalli VK. Impact of provider level, training and gender on the utilization of palliative care and hospice in neuro-oncology: a North-American survey J Neurooncol 2016; 126(2):337-345. PMID: 26518539. Full Text

Yadav VN, Zamler D, Baker GJ, Kadiyala P, Erdreich-Epstein A, DeCarvalho AC, Mikkelsen T, Castro MG, and Lowenstein PR. CXCR4 increases in-vivo glioma perivascular invasion, and reduces radiation induced apoptosis: A genetic knockdown study Oncotarget 2016;PMID: 27863376. Full Text

Zhang L, Chopp M, Zhang Y, Xiong Y, Li C, Sadry N, Rhaleb I, Lu M, and Zhang ZG. Diabetes mellitus impairs cognitive function in middle-aged rats and neurological recovery in middle-aged rats after stroke Stroke 2016; 47(8):2112-2118. PMID: 27387991. Full Text

Zhang Y, Zhang ZG, Chopp M, Meng Y, Zhang L, Mahmood A, and Xiong Y. Treatment of traumatic brain injury in rats with N-acetyl-seryl-aspartyl-lysyl-proline J Neurosurg 2016:1-14. PMID: 27203137. Full Text

Zhang Y, Chopp M, Zhang ZG, Katakowski M, Xin H, Qu C, Ali M, Mahmood A, and Xiong Y. Systemic administration of cell-free exosomes generated by human bone marrow derived mesenchymal stem cells cultured under 2D and 3D conditions improves functional recovery in rats after traumatic brain injury Neurochem Int 2016;PMID: 27539657. Article Request Form

92 NURSING

Everson C. Clinical nurse educator's perspective Aorn Journal 2016; 103(3):325-326. PMID: Not assigned. [Everson, Claire] Henry Ford Macomb Hosp, Clinton Township, MI USA. Article Request Form

Gammon HM, Shelton CB, Siegert C, Dawson C, Sexton E, Burmeister C, Gnam G, and Siddiqui A. Self-turning for pressure injury prevention Wound Medicine 2016; 12:15-18. PMID: Not assigned Article Request Form

Klassa PJ, Dendrinos S, Penn A, and Radke J. Shared decision making: Through the patient's eyes J Perinat Neonatal Nurs 2016; 30(3):228-232. PMID: 27465455. Full Text

93 OBSTETRICS, GYNECOLOGY AND WOMEN’S HEALTH SERVICES

Adekola H, Gill N, Sakr S, Hobson D, Bryant D, Abramowicz JS, and Soto E. Outcomes following intra- amniotic instillation with indigo carmine to diagnose prelabor rupture of membranes in singleton pregnancies: a single center experience J Matern Fetal Neonatal Med 2016; 29(4):544-549. PMID: 25714481. Article Request Form

Al Feghali KA, Robbins JR, Mahan M, Burmeister C, Khan NT, Rasool N, Munkarah A, and Elshaikh MA. Predictive capacity of 3 comorbidity indices in estimating survival endpoints in women with early-stage endometrial carcinoma Int J Gynecol Cancer 2016;PMID: 27488218. Full Text

Baker-Genaw K, Kokas MS, Ahsan SF, Darnley-Fisch D, Drake S, Goyal N, Inamdar K, Moutzouros V, Prabhakar D, Rolland L, Sangha R, Shreve M, and Woodward A. Mapping direct observations from objective structured clinical examinations to the milestones across specialties J Grad Med Educ 2016; 8(3):429-434. PMID: 27413450. Full Text

Eziefule AA, Elshatanoufy S, Thakur M, and Rocha FG. Propofol-related infusion syndrome in the peripartum period AJP Rep 2016; 6(4):e368-e371. PMID: 27738550. Full Text

Faucher MA, Collins-Fulea C, and Breedlove G. Collaboration in practice: Implementing team-based practice: A midwifery perspective J Midwifery Womens Health 2016; 61(4):408-410. PMID: 27352212. Full Text

Feldman AM, Zhang Z, Buekers T, and Elshaikh MA. Management of gynaecologic plasmacytoma: A review article J Obstet Gynaecol 2016:1-6. PMID: 27760483. Article request form

Hijaz M, Das S, Mert I, Gupta A, Al-Wahab Z, Tebbe C, Dar S, Chhina J, Giri S, Munkarah A, Seal S, and Rattan R. Folic acid tagged nanoceria as a novel therapeutic agent in ovarian cancer BMC Cancer 2016; 16(1):220. PMID: 26979107. Full Text

Hijaz M, Chhina J, Mert I, Taylor M, Dar S, Al-Wahab Z, Ali-Fehmi R, Buekers T, Munkarah AR, and Rattan R. Preclinical evaluation of olaparib and metformin combination in BRCA1 wildtype ovarian cancer Gynecol Oncol 2016;PMID: 27282964. Full Text

Isrow D, Burmeister C, Hanna RK, and Elshaikh MA. Survival endpoints for young women with early stage uterine endometrioid carcinoma: a matched analysis Eur J Obstet Gynecol Reprod Biol 2016; 207:115-120. PMID: 27838535. Full Text

Jaber S, Winer I, and Rasool N. Recurrent omental hemangiopericytoma: A therapeutic challenge Case Rep Obstet Gynecol 2016; 2016:2075157. PMID: 27088021. Full Text

Jaffee KD, Shires DA, and Stroumsa D. Discrimination and delayed health care among transgender women and men: Implications for improving medical education and health care delivery Med Care 2016;PMID: 27314263. Full Text

Khangura RK, Khangura CK, Desai A, Goyert G, and Sangha R. Metastatic colorectal cancer resembling severe preeclampsia in pregnancy Case Rep Obstet Gynecol 2015; 2015:487824. PMID: 26770850. Full Text

Mangalam AK, Rattan R, Suhail H, Singh J, Hoda MN, Deshpande M, Fulzele S, Denic A, Shridhar V, Kumar A, Viollet B, Rodriguez M, and Giri S. AMP-activated protein kinase suppresses autoimmune central nervous system disease by regulating m1-type macrophage-th17 axis J Immunol 2016;PMID: 27354217. Full Text

Mazloomdoost D, Kanter G, Chan RC, Deveaneau N, Wyman AM, Von Bargen EC, Chaudhry Z, Elshatanoufy S, Miranne JM, Chu CM, Pauls RN, Arya LA, and Antosh DD. Social networking and internet use among pelvic floor patients: a multicenter survey Am J Obstet Gynecol 2016; 215(5):654.e651-654.e610. PMID: 27319368. Full Text

94 Miller-Matero LR, Chipungu K, Martinez S, Eshelman A, and Eisenstein D. How do I cope with pain? Let me count the ways: awareness of pain coping behaviors and relationships with depression and anxiety Psychol Health Med 2016:1-9. PMID: 27221277. Article Request Form

Modh A, Ghanem AI, Burmeister C, Rasool N, and Elshaikh MA. Trends in the utilization of adjuvant vaginal brachytherapy in women with early-stage endometrial carcinoma: Results of an updated period analysis of SEER data Brachytherapy 2016;PMID: 27475480. Full Text

Munkarah A, Mert I, Chhina J, Hamid S, Poisson L, Hensley-Alford S, Giri S, and Rattan R. Targeting of free fatty acid receptor 1 in EOC: A novel strategy to restrict the adipocyte-EOC dependence Gynecol Oncol 2016; 141(1):72-79. PMID: 27016232. Full Text

Ondersma SJ, Beatty JR, Rosano TG, Strickler RC, Graham AE, and Sokol RJ. Commercial ethyl glucuronide (etg) and ethyl sulfate (ets) testing is not vulnerable to incidental alcohol exposure in pregnant women Subst Use Misuse 2016; 51(1):126-130. PMID: 26771303. Article Request Form

Rana S, Blowers EC, Tebbe C, Contreras JI, Radhakrishnan P, Kizhake S, Zhou T, Rajule RN, Arnst JL, Munkarah AR, Rattan R, and Natarajan A. Isatin derived spirocyclic analogues with alpha- methylene- gamma-butyrolactone as anticancer agents: A structure-activity relationship study J Med Chem 2016;PMID: 27077228. Article Request Form

Randall TC, Goodman A, Schmeler K, Durfee J, Pareja R, Munkarah A, Rulisa S, Ghebre R, Trimble EL, and Chuang L. Cancer and the world's poor: What's a gynecologic cancer specialist to do? Gynecol Oncol 2016;PMID: 27210817. Full Text

Rauch K, Hicks M, Adekola H, and Abramowicz J. Aneuploidy screening: The ongoing role of first- trimester ultrasound First-Trimester Ultrasound 2016:131-152. PMID: Not assigned - Book chapter. Book Request Form

Sangha R, Katukuri V, Palmer M, and Khangura RK. Recurrence after robotic myomectomy: is it associated with use of GnRH agonist? J Robot Surg 2016;PMID: 27072151. Full Text

Schiff L, Tsafrir Z, Aoun J, Taylor A, Theoharis E, and Eisenstein D. Quality of communication in robotic surgery and surgical outcomes Jsls 2016; 20(3)PMID: 27493469. Full Text

Swain M, Jeudy M, and Pearlman MD. Controversies in screening mammography Clin Obstet Gynecol 2016; 59(2):351-361. PMID: 27101240. Full Text

Toubia T, Schiff L, Wegienka G, and Sangha R. Extended length of stay after robotic-assisted hysterectomy: Association with uterine weight and other risk factors J Gynecol Surg 2016; 32(1):19-23. PMID: Not assigned. Article Request Form

Tsafrir Z, Aoun J, Hanna R, Papalekas E, Schiff L, Theoharis E, and Eisenstein D. Robotic trachelectomy after supracervical hysterectomy for benign gynecologic disease Jsls 2016; 20(3)PMID: 27493470. Full Text

Tsafrir Z, Palmer M, Dahlman M, Nawfal AK, Aoun J, Taylor A, Fisher J, Theoharis E, and Eisenstein D. Long- term outcomes for different vaginal cuff closure techniques in robotic-assisted laparoscopic hysterectomy: A randomized controlled trial Eur J Obstet Gynecol Reprod Biol 2016; 210:7-12. PMID: 27923167. Full text

Vance S, Burmeister C, Rasool N, Buekers T, and Elshaikh MA. Salvage versus adjuvant radiation treatment for women with early-stage endometrial carcinoma: A matched analysis Int J Gynecol Cancer 2016; 26(2):307-312. PMID: 26745700. Full Text

Wahid M, Mandal RK, Dar SA, Jawed A, Lohani M, Areeshi MY, Akhter N, and Haque S. Therapeutic potential and critical analysis of trastuzumab and bevacizumab in combination with different chemotherapeutic agents against metastatic breast/colorectal cancer affecting various endpoints Crit Rev Oncol Hematol 2016;PMID: 27357488. Full Text

95 Wang W, Kryczek I, Dostal L, Lin H, Tan L, Zhao L, Lu F, Wei S, Maj T, Peng D, He G, Vatan L, Szeliga W, Kuick R, Kotarski J, Tarkowski R, Dou Y, Rattan R, Munkarah A, Liu JR, and Zou W. Effector t cells abrogate stroma- mediated chemoresistance in ovarian cancer Cell 2016; 165(5):1092- 1105. PMID: 27133165. Article Request Form

Wegienka G, Kaur H, Sangha R, and Cassidy-Bushrow AE. Maternal-cord blood vitamin d correlations vary by maternal levels J Pregnancy 2016; 2016:7474192. PMID: 27066272. Full Text

Xu Y, Burmeister C, Hanna RK, Munkarah A, and Elshaikh MA. Predictors of survival after recurrence in women with early-stage endometrial carcinoma Int J Gynecol Cancer 2016;PMID: 27206283. Full Text

96 OPTHALMOLOGY AND EYE CARE SERVICES

Baciu P, Nofar CM, Spaulding J, and Gao H. Branch retinal artery occlusion associated with paracentral acute middle maculopathy in a patient with livedo reticularis Retin Cases Brief Rep 2016;PMID: 27490977. Full Text

Baker-Genaw K, Kokas MS, Ahsan SF, Darnley-Fisch D, Drake S, Goyal N, Inamdar K, Moutzouros V, Prabhakar D, Rolland L, Sangha R, Shreve M, and Woodward A. Mapping direct observations from objective structured clinical examinations to the milestones across specialties J Grad Med Educ 2016; 8(3):429-434. PMID: 27413450. Full Text

Cheung AY, David JA, and Ober MD. Spontaneous bilateral hemorrhagic choroidal detachments associated with malignant hypertension Retin Cases Brief Rep 2016;PMID: 27177073. Full Text

Elfersy AJ, Prinzi RA, Peracha ZH, Kim DD, Crandall DA, Darnley-Fisch DA, and Imami NR. IOP elevation after cataract surgery: Results for residents and senior staff at henry ford health system J Glaucoma 2016; 25(10):802- 806. PMID: 27027228. Full Text

Farley ND, Sassalos TM, and Ober MD. Basal cell nevus syndrome presenting as epiretinal membrane and myelinated nerve fiber layer Retin Cases Brief Rep 2016;PMID: 27533646. Full Text

Hessburg PC, Rizzo J, and O'Malley ER. Preface: The eye and the chip world research congress on visual neuro-prosthetics J Neural Eng 2016; 13(2):020401. PMID: 26904980. Article Request Form

Im M, and Fried SI. Temporal properties of network-mediated responses to repetitive stimuli are dependent upon retinal ganglion cell type J Neural Eng 2016; 13(2):025002. PMID: 26905231. Article Request Form

Mogk LG. Re: State-of-the-art: low vision rehabilitation, S. Markowitz, Vol. 51, No. 2, April 2016 Can J Ophthalmol 2016; 51(6):494. PMID: 27938967. Full text

Peracha ZH, Ahmed SB, Desai A, Peracha-Riyaz M, Kumar N, and Desai UR. Saturday night retinopathy: Characterization of a rare ophthalmic condition Ophthalmic Surg Lasers Imaging Retina 2016; 47(1):85-89. PMID: 26731217. Article Request Form

Tse SM, Farley ND, Tomasko KR, and Amin SR. Intraoperative LASIK Complications Int Ophthalmol Clin 2016; 56(2):47-57. PMID: 26938337. Full Text

Vemuri S, Christianson MD, and Demirci H. Correcting myogenic ptosis accompanying extraocular muscle weakness: The "Bobby Pin" procedure Orbit 2016; 35(5):267-270. PMID: 27541941. Article Request Form

Wang SY, Ghodasra DH, Amin SR, Mian SI, and Jayasundera KT. Fungal endophthalmitis associated with DSAEK and thermal sclerostomy Ophthalmic Surg Lasers Imaging Retina 2016; 47(7):691-693. PMID: 27434905. Article Request Form

Woodward MA, Bavinger JC, Amin S, Blachley TS, Musch DC, Lee PP, and Newman-Casey PA. Telemedicine for ophthalmic consultation services: use of a portable device and layering information for graders J Telemed Telecare 2016;PMID: 26936864. Full Text

97 ORTHOPAEDICS

Baumer TG, Giles JW, Drake A, Zauel R, and Bey MJ. Measuring three-dimensional thorax motion via biplane radiographic imaging: Technique and preliminary results J Biomech Eng 2016; 138(1)PMID: 26592901. Article Request Form

Baumer TG, Chan D, Mende V, Dischler J, Zauel R, van Holsbeeck M, Siegal DS, Divine G, Moutzouros V, and Bey MJ. Effects of rotator cuff pathology and physical therapy on in vivo shoulder motion and clinical outcomes in patients with a symptomatic full-thickness rotator cuff tear Orthop J Sports Med 2016; 4(9)PMID: 27734020. Full Text

Charters MA, Frisch NB, Wessell NM, Dobson C, Les CM, and Silverton CD. Rivaroxaban versus enoxaparin for venous thromboembolism prophylaxis after hip and knee arthroplasty J Arthroplasty 2015; 30(7):1277-1280. PMID: 25724111. Full Text

Chiu MD, Vasileff WK, Moutzouros V, Van Holsbeeck M, Parsons TW, and Mott MP. Bilateral and simultaneous septic arthritis of the acromioclavicular joint in an immunocompromised patient: A case report and review of the literature Current Orthopaedic Practice 2016; 27(5):570-574. PMID: Not assigned. Full Text

Dugarte A, Bharwani S, Yoo H, Boiwka AV, Yu CC, Bajwa NS, Toy JO, Tang JE, Ahn U, and Ahn N. Calcaneocuboid joint arthritis of the midfoot precedes tibiotalar joint arthritis Orthopedics 2016; 39(6):e1112-e1116. PMID: 27575040. Article Request Form

Feist C, Holden P, and Fitzgerald J. Novel compound heterozygous mutations in inositol polyphosphate phosphatase-like 1 in a family with severe opsismodysplasia Clin Dysmorphol 2016;PMID: 27233067. Full Text

Fitzgerald J. New insights into articular cartilage regeneration Semin Cell Dev Biol 2016;PMID: 27130635. Article Request Form

Fradet A, and Fitzgerald J. INPPL1 gene mutations in opsismodysplasia J Hum Genet 2016;PMID: 27708270. Article request form

Frisch NB, Lynch JR, Banglmaier RF, and Silverton CD. The effect of impact location on force transmission to the modular junctions of dual-taper modular hip implants J Arthroplasty 2016;PMID: 26970905. Full Text

Frisch N, Wessell NM, Charters M, Peterson E, Cann B, Greenstein A, and Silverton CD. Effect of body mass index on blood transfusion in total hip and knee arthroplasty Orthopedics 2016; 39(5):e844- 849. PMID: 27172370. Article request form

Frisch NB, Lynch JR, Banglmaier RF, and Silverton CD. The stability of dual-taper modular hip implants: A biomechanical analysis examining the effect of impact location on component stability Arthroplasty Today 2016;PMID: Not assigned. Full Text

Frisch NB, Pepper AM, Jildeh TR, Shaw J, Guthrie T, and Silverton C. Intraoperative hypothermia during surgical fixation of hip fractures Orthopedics 2016; 39(6):e1170-e1177. PMID: 27536952. Article Request Form

Gardinier JD, Al-Omaishi S, Morris MD, and Kohn DH. PTH signaling mediates perilacunar remodeling during exercise Matrix Biol 2016;PMID: 26924474. Article Request Form

Keller RA, Marshall NE, Bey MJ, Ahmed H, Scher CE, van Holsbeeck M, and Moutzouros V. Pre- and postseason dynamic ultrasound evaluation of the pitching elbow Arthroscopy 2015; 31(9):1708- 1715. PMID: 26354194. Full Text

98 Keller RA, Marshall NE, Guest JM, Okoroha KR, Jung EK, and Moutzouros V. Major League Baseball pitch velocity and pitch type associated with risk of ulnar collateral ligament injury J Shoulder Elbow Surg 2016; 25(4):671- 675. PMID: 26995458. Full Text

Li B, Singer NG, Yeni YN, Haggins DG, Barnboym E, Oravec D, Lewis S, and Akkus O. A point of care Raman spectroscopy based device to diagnose gout and pseudogout: Comparison with the clinical standard microscopic analysis Arthritis Rheumatol 2016;PMID: 26882173. Full Text

Li W, Molnar SL, Mott M, White E, and De Las Casas LE. Superficial CD34-positive fibroblastic tumor: Cytologic features, tissue correlation, ancillary studies, and differential diagnosis of a recently described soft tissue neoplasm Diagn Cytopathol 2016;PMID: 27432164. Full Text

Liu JZ, Frisch NB, Barden RM, Rosenberg AG, Silverton CD, and Galante JO. Heterotopic ossification prophylaxis after total hip arthroplasty: Randomized trial of 400 vs 700 cgy J Arthroplasty 2016;PMID: 27884418. Full Text

Makhni EC, Saltzman BM, Meyer MA, Moutzouros V, Cole BJ, Romeo AA, and Verma NN. Outcomes after shoulder and elbow injury in baseball players: are we reporting what matters? Am J Sports Med 2016;PMID: 27159299. Full Text

Makhni EC, Weber AE, Ball B, and Thomas A. Principles of Postoperative Shoulder Rehabilitation in Throwing Athletes Oper Tech Sports Med 2016;PMID: Not assigned. Full Text

Marshall NE, Keller RA, Okoroha K, Guest JM, Yu C, Muh S, and Moutzouros V. Radiostereometric evaluation of tendon elongation after distal biceps repair Orthop J Sports Med 2016; 4(11):2325967116672620. PMID: 27928546. Full text

Mehran N, Williams PN, Keller RA, Khalil LS, Lombardo SJ, and Kharrazi FD. Athletic performance at the national basketball association combine after anterior cruciate ligament reconstruction Orthop J Sports Med 2016; 4(5):2325967116648083. PMID: 27294169. Full Text

Nelson F, Bokhari O, Oravec D, Kim W, Flynn M, Lumley C, McPhilamy A, and Yeni YN. The use of tomosynthesis in the global study of knee subchondral insufficiency fractures Acad Radiol 2016;PMID: 28010915. Full text

North WT, Mehran N, Davis JJ, Silverton CD, Weir RM, and Laker MW. Topical vs intravenous tranexamic acid in primary total hip arthroplasty: A double-blind, randomized controlled trial J Arthroplasty 2016; 31(4):928-929. PMID: 26783121. Full Text

Okoroha KR, Keller RA, Marshall NE, Jung EK, Mehran N, Owashi E, and Moutzouros V. Liposomal bupivacaine versus femoral nerve block for pain control after anterior cruciate ligament reconstruction: A prospective randomized trial Arthroscopy 2016;PMID: 27349715. Full Text

Okoroha KR, Lynch JR, Keller RA, Korona J, Amato C, Rill B, Kolowich PA, and Muh SJ. Liposomal bupivacaine versus interscalene nerve block for pain control after shoulder arthroplasty: a prospective randomized trial J Shoulder Elbow Surg 2016;PMID: 27422692. Full Text

Pepper AM, North TW, Sunderland AM, and Davis JJ. Intraoperative adductor canal block for augmentation of periarticular injection in total knee arthroplasty: A cadaveric study J Arthroplasty 2016;PMID: 26996675. Full Text

Qiu S, Divine GW, Palnitkar S, Kulkarni P, Guthrie TS, Honasoge M, and Rao SD. Bone structure and turnover status in postmenopausal women with atypical femur fracture after prolonged bisphosphonate therapy Calcif Tissue Int 2016;PMID: 28013363. Full text

Setzer TJ, Sundellranby I, Les C, Pechy C, and Beste S. Detecting malaria parasites postmortem: Experiments, results, and implications Am J Phys Anthropol 2016; 159:288. PMID: Not assigned. Article Request Form

99

Slotkin S, Frisch NB, Roc G, and Silverton CD. Hemispherical and minimally invasive total hip reamers: A biomechanical analysis of use and design Arthroplasty Today 2016;PMID: Not assigned. Full text

Vallier HA, Moore TA, and Nahm NJ. Re: Issues regarding patient assessment scores that focus on acid base changes in fracture patients J Trauma Acute Care Surg 2016;PMID: 26885999. Full Text

Wessell N, Khalil J, Zavatsky J, Ghacham W, and Bartol S. Verification of nerve decompression using mechanomyography Spine J 2016;PMID: 26940191. Full Text

Wessell NM, Martus JE, Halanski MA, Snyder B, and Truong W. What's new in pediatric spine growth modulation and implant technology for early-onset scoliosis? J Pediatr Orthop 2016;PMID: 27403917. Full Text

Zhang L, Yang M, Mayer T, Johnstone B, Les C, Frisch N, Parsons T, Mi QS, and Gibson G. Use of MicroRNA biomarkers to distinguish enchondroma from low-grade chondrosarcoma Connect Tissue Res 2016:1-7. PMID: 27267924. Article Request Form

Physical therapy

Arena SK, Simon L, and Peterson EL. Aneroid blood pressure manometer calibration rates in physical therapy curricula: A descriptive study Cardiopulm Phys Ther J 2016; 27(2):56-61. PMID: Not assigned. Full Text

Baumer TG, Chan D, Mende V, Dischler J, Zauel R, van Holsbeeck M, Siegal DS, Divine G, Moutzouros V, and Bey MJ. Effects of rotator cuff pathology and physical therapy on in vivo shoulder motion and clinical outcomes in patients with a symptomatic full-thickness rotator cuff tear Orthop J Sports Med 2016; 4(9)PMID: 27734020. Full Text

Podiatry

Burson LK, and Schank CH. Charcot neuroarthropathy of the foot and ankle Home Healthc Now 2016; 34(3):135-139. PMID: 26925938. Article Request Form

100 OTOLARYNGOLOGY AND HEAD AND NECK SURGERY

Asher BF, Seidman MD, Reddy WD, and Omole FS. Integrative medical approaches to allergic rhinitis Curr Opin Otolaryngol Head Neck Surg 2015; 23(3):221-225. PMID: 25943958. Full Text

Baker-Genaw K, Kokas MS, Ahsan SF, Darnley-Fisch D, Drake S, Goyal N, Inamdar K, Moutzouros V, Prabhakar D, Rolland L, Sangha R, Shreve M, and Woodward A. Mapping direct observations from objective structured clinical examinations to the milestones across specialties J Grad Med Educ 2016; 8(3):429-434. PMID: 27413450. Full Text

Choi SH, Terrell JE, Fowler KE, McLean SA, Ghanem T, Wolf GT, Bradford CR, Taylor J, and Duffy SA. Socioeconomic and other demographic disparities predicting survival among head and neck cancer patients PLoS One 2016; 11(3):e0149886. PMID: 26930647. Full Text

Choi SH, Terrell JE, Bradford CR, Ghanem T, Spector ME, Wolf GT, Lipkus IM, and Duffy SA. Does quitting smoking make a difference among newly diagnosed head and neck cancer patients? Nicotine Tob Res 2016;PMID: 27613928. Full Text

Craig JR, Zhao K, Doan N, Khalili S, Lee JY, Adappa ND, and Palmer JN. Cadaveric validation study of computational fluid dynamics model of sinus irrigations before and after sinus surgery Int Forum Allergy Rhinol 2016;PMID: 26880742. Article Request Form

Craig JR, Petrov D, Khalili S, Brooks SG, Lee JY, Adappa ND, and Palmer JN. The nasofrontal beak: A consistent landmark for superior septectomy during Draf III drill out Am J Rhinol Allergy 2016; 30(3):230-234. PMID: 27216356. Article Request Form

Duke WS, Holsinger FC, Kandil E, Richmon JD, Singer MC, and Terris DJ. Remote access robotic facelift thyroidectomy: A multi-institutional experience World J Surg 2016;PMID: 27738835. Full Text

Garcia-Rodriguez L, Dharia R, and Massey B. Ectopic thyroid tissue with Hashimoto’s thyroiditis Wis Med J 2016; 115(1):46-48. PMID: 27057580. Full Text

Garcia-Rodriguez L, Jones L, Chen KM, Datta I, Divine G, and Worsham MJ. Causal network analysis of head and neck keloid tissue identifies potential master regulators Laryngoscope 2016;PMID: 26990118. Full Text

Garcia-Rodriguez L, Dharia R, Heilbronn C, and Ghanem T. Unconventional fix for an orocutaneous fistula Ear Nose Throat J 2016; 95(6):212-215. PMID: 27304437. Full Text

Gross ND, Holsinger FC, Magnuson JS, Duvvuri U, Genden EM, Ghanem TA, Yaremchuk KL, Goldenberg D, Miller MC, Moore EJ, Morris LG, Netterville J, Weinstein GS, and Richmon J. Robotics in otolaryngology and head and neck surgery: Recommendations for training and credentialing: A report of the 2015 AHNS education committee, AAO-HNS robotic task force and AAO-HNS sleep disorders committee Head Neck 2016;PMID: 26950771. Full Text

Miller AJ, Bobian M, Peterson E, and Deeb R. Bleeding risk associated with resection of the middle turbinate during functional endoscopic sinus surgery Am J Rhinol Allergy 2016; 30(2):140-142. PMID: 26980395. Article Request Form

Miller A, Hall F, and Ahsan S. Chronic otitis media with effusion following radiation therapy Ear Nose Throat J 2016; 95(10-11):E26-e31. PMID: 27792830. Full Text

Newman LA, Stark A, Chitale D, Pepe M, Longton G, Worsham MJ, Nathanson SD, Miller P, Bensenhaver JM, Proctor E, Swain M, Patriotis C, and Engstrom PF. Association between benign breast disease in african american and white american women and subsequent triple-negative breast cancer JAMA Oncol 2016;PMID: 28006062. Full text

101

Noyek S, Yaremchuk K, and Rotenberg B. Does melatonin have a meaningful role as a sleep aid for jet lag recovery? Laryngoscope 2016;PMID: 27238501. Full Text

Siddiqui F, Bentley GA, McLean SA, and Ryu S. Inflammatory pseudotumor of the pharynx: A rare entity Indian J Cancer 2015; 52(4):668-669. PMID: 26960513. Full Text

Turfe Z, Pettinga J, Leduc O, Leduc A, and Komorowska-Timek E. Chemotherapy port related lymphedema after axillary lymph node dissection Breast 2016; 28:145-147. PMID: 27318169. Full Text

Witsell DL, Khoury T, Schulz KA, Stachler R, Tucci DL, and Wojdyla D. Evaluation of compliance for treatment of sudden hearing loss: A CHEER network study Otolaryngol Head Neck Surg 2016; 155(1):48-55. PMID: 27371626. Full Text

Worsham MJ, Chen KM, Datta I, Stephen JK, Chitale D, Gothard A, and Divine G. The biological significance of methylome differences in human papilloma virus associated head and neck cancer Oncology Letters 2016; 12(6):4949-4956. PMID: Not assigned. Article Request Form

Yaremchuk K. Palatal procedures for obstructive sleep apnea Otolaryngol Clin North Am 2016;PMID: 27720460. Full Text

102 PATHOLOGY

Alikhan M, Song JY, Sohani AR, Moroch J, Plonquet A, Duffield AS, Borowitz MJ, Jiang L, Bueso- Ramos C, Inamdar K, Menon MP, Gurbuxani S, Chan E, Smith SM, Nicolae A, Jaffe ES, Gaulard P, and Venkataraman G. Peripheral T- cell lymphomas of follicular helper T-cell type frequently display an aberrant CD3-/dimCD4+ population by flow cytometry: an important clue to the diagnosis of a Hodgkin lymphoma mimic Mod Pathol 2016;PMID: 27312067. Full Text

Baker-Genaw K, Kokas MS, Ahsan SF, Darnley-Fisch D, Drake S, Goyal N, Inamdar K, Moutzouros V, Prabhakar D, Rolland L, Sangha R, Shreve M, and Woodward A. Mapping direct observations from objective structured clinical examinations to the milestones across specialties J Grad Med Educ 2016; 8(3):429-434. PMID: 27413450. Full Text

Baldwin BJ, Chitale D, Chen KM, Worsham MJ, and Yaremchuk K. Investigation into the presence of human papillomavirus in patients with obstructive sleep apnea Laryngoscope 2016;PMID: 27412085. Full Text

Calio A, Eble JN, Hes O, Martignoni G, Harari SE, Williamson SR, Brunelli M, Osunkoya AO, Wang L, Comperat E, Lopez-Beltran A, Wang M, Zhang S, Curless KL, Post KM, Chang HY, Luchini C, Baldrige LA, MacLennan GT, Montironi R, Grignon DJ, and Cheng L. Distinct clinicopathological features in metanephric adenoma harboring BRAF mutation Oncotarget 2016;PMID: 27517493. Full Text

Calio A, Grignon DJ, Stohr BA, Williamson SR, Eble JN, and Cheng L. Renal cell carcinoma with TFE3 translocation and succinate dehydrogenase B mutation Mod Pathol 2016;PMID: 27910947. Full Text

Fisher KW, Zhang S, Wang M, Montironi R, Wang L, Baldrige LA, Wang JY, MacLennan GT, Williamson SR, Lopez- Beltran A, and Cheng L. TMPRSS2-ERG gene fusion is rare compared to PTEN deletions in stage T1a prostate cancer Mol Carcinog 2016;PMID: 27500376. Full Text

Flynt LK, Veve MP, Samuel LP, and Tibbetts RJ. Ceftolozane-tazobactam susceptibility testing of Pseudomonas aeruginosa: a comparison of Etest to broth microdilution J Clin Microbiol 2016;PMID: 27795348. Article Request Form

Gomez-Gelvez JC, Salama ME, Perkins SL, Leavitt M, and Inamdar KV. Prognostic impact of tumor microenvironment in diffuse large b-cell lymphoma uniformly treated with r-chop chemotherapy Am J Clin Pathol 2016; 145(4):514-523. PMID: 27124945. Full Text

Gulati R, Alkhatib Y, Donthireddy V, Felicella MM, Menon MP, and Inamdar KV. Isolated ocular manifestation of relapsed chronic myelogenous leukemia presenting as myeloid blast crisis in a patient on imatinib therapy: A case report and review of the literature Case Rep Pathol 2015; 2015:380451. PMID: 26819793. Full Text

Hwang C, Sethi S, Heilbrun LK, Gupta NS, Chitale DA, Sakr WA, Menon M, Peabody JO, Smith DW, Sarkar FH, and Heath EI. Anti-androgenic activity of absorption-enhanced 3, 3'- diindolylmethane in prostatectomy patients Am J Transl Res 2016; 8(1):166-176. PMID: 27069550. Full Text

Jiagge E, Jibril AS, Chitale D, Bensenhaver JM, Awuah B, Hoenerhoff M, Adjei E, Bekele M, Abebe E, Nathanson SD, Gyan K, Salem B, Oppong J, Aitpillah F, Kyei I, Bonsu EO, Proctor E, Merajver SD, Wicha M, Stark A, and Newman LA. Comparative analysis of breast cancer phenotypes in african american, white american, and west versus east african patients: Correlation between african ancestry and triple-negative breast cancer Ann Surg Oncol 2016;PMID: 27469125. Full Text

Jones LR, Greene J, Chen KM, Divine G, Chitale D, Shah V, Datta I, and Worsham MJ. Biological significance of genome-wide DNA methylation profiles in keloids Laryngoscope 2016;PMID: 27312686. Full Text

103

Joseph L, Cankovic M, Caughron S, Chandra P, Emmadi R, Hagenkord J, Hallam S, Jewell KE, Klein RD, Pratt VM, Rothberg PG, Temple-Smolkin RL, and Lyon E. The spectrum of clinical utilities in molecular pathology testing procedures for inherited conditions and cancer: A report of the association for molecular pathology J Mol Diagn 2016; 18(5):605-619. PMID: 27542512. Full Text

Kenney RM, Cole KA, Perri MB, Dumkow LE, Samuel LP, Zervos MJ, and Davis SL. Reply to "urinary tract infections: Resistance is futile" Antimicrob Agents Chemother 2016; 60(4):2598. PMID: 27016558. Full Text

Kouba EJ, Eble JN, Simper N, Grignon DJ, Wang M, Zhang S, Wang L, Martignoni G, Williamson SR, Brunelli M, Luchini C, Calio A, and Cheng L. High fidelity of driver chromosomal alterations among primary and metastatic renal cell carcinomas: implications for tumor clonal evolution and treatment Mod Pathol 2016; 29(11):1347-1357. PMID: 27469331. Full Text

Kouba E, Simper NB, Chen S, Williamson SR, Grignon DJ, Eble JN, MacLennan GT, Montironi R, Lopez-Beltran A, Osunkoya AO, Zhang S, Wang M, Wang L, Tran T, Emerson RE, Baldrige LA, Monn MF, Linos K, and Cheng L. Solitary fibrous tumour of the genitourinary tract: a clinicopathological study of 11 cases and their association with the NAB2-STAT6 fusion gene J Clin Pathol 2016;PMID: 27802414. Full Text

Krasnick BA, Nathanson SD, Arbabi CN, Chitale DA, and Peterson EL. The predictive value of increased sentinel lymph node volume in breast cancer Surg Oncol 2016; 25(3):321-325. PMID: 27566039. Full Text

Kryvenko ON, Williamson SR, Trpkov K, Gupta NS, Athanazio D, Selig MK, Smith PT, Magi-Galluzzi C, and Jorda M. Small cell-like glandular proliferation of prostate: a rare lesion not related to small cell prostate cancer Virchows Arch 2016;PMID: 27743032. Full Text

Lindquist KJ, Paris PL, Hoffmann TJ, Cardin NJ, Kazma R, Mefford JA, Simko JP, Ngo V, Chen Y, Levin AM, Chitale D, Helfand BT, Catalona WJ, Rybicki BA, and Witte JS. Mutational landscape of aggressive prostate tumors in African American men Cancer Res 2016;PMID: 26921337. Full Text

Meighani A, Jafri SM, Raoufi M, and Salgia R. Splenic artery embolization for treatment of refractory ascites after liver transplantation ACG Case Rep J 2016; 3(2):136-138. PMID: 26958571. Full Text

Newman LA, Stark A, Chitale D, Pepe M, Longton G, Worsham MJ, Nathanson SD, Miller P, Bensenhaver JM, Proctor E, Swain M, Patriotis C, and Engstrom PF. Association between benign breast disease in african american and white american women and subsequent triple-negative breast cancer JAMA Oncol 2016;PMID: 28006062. Full text

Parekh R, Kazimi M, Skorupski S, Fagoaga O, Jafri S, and Segovia MC. Intestine transplantation across a positive crossmatch with preformed donor-specific antibodies Transplant Proc 2016; 48(2):489-491. PMID: 27109984. Full Text

Parikh Y, Sharma KJ, Parikh SJ, and Hall D. Intramammary schwannoma: a palpable breast mass Radiol Case Rep 2016; 11(3):129-133. PMID: 27594933. Full Text

Priemer DS, Montironi R, Wang L, Williamson SR, Lopez-Beltran A, and Cheng L. Neuroendocrine tumors of the prostate: Emerging insights from molecular data and updates to the 2016 world health organization classification Endocr Pathol 2016;PMID: 26885643. Full Text

Rao B, Jafri SM, Kazimi M, Mullins K, Raoufi M, and Segovia MC. A case report of acute cellular rejection following intestinal transplantation managed with adalimumab Transplant Proc 2016; 48(2):536-538. PMID: 27109995. Full Text

Rao B, Segovia MC, Kazimi M, Parekh R, Raoufi M, and Jafri SM. Use of everolimus after multivisceral transplantation: A report of two cases Transplant Proc 2016; 48(2):485-488. PMID: 27109983. Full Text

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Rayson D, Lupichuk S, Potvin K, Dent S, Shenkier T, Dhesy-Thind S, Ellard SL, Prady C, Salim M, Farmer P, Allo G, Tsao MS, Allan A, Ludkovski O, Bonomi M, Tu D, Hagerman L, Goodwin R, Eisenhauer E, and Bradbury P. Canadian Cancer Trials Group IND197: a phase II study of foretinib in patients with estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2- negative recurrent or metastatic breast cancer Breast Cancer Res Treat 2016; 157(1):109-116. PMID: 27116183. Full Text

Rybicki BA, Rundle A, Kryvenko ON, Mitrache N, Do KC, Jankowski M, Chitale DA, Trudeau S, Belinsky SA, and Tang D. Methylation in benign prostate and risk of disease progression in men subsequently diagnosed with prostate cancer Int J Cancer 2016;PMID: 26860439. Full Text

Samuel LP, Balada-Llasat JM, Harrington A, and Cavagnolo R. Multicenter assessment of gram stain error rates J Clin Microbiol 2016;PMID: 26888900. Article Request Form

Samuel LP, Balada-Llasat JM, Harrington A, and Cavagnolo R. Correction for samuel et al., multicenter assessment of gram stain error rates J Clin Microbiol 2016; 54(9):2405. PMID: 27578160. Full Text

Saste A, Arias-Stella J, and Kuriakose P. Progression of a hepatosplenic gamma delta T-cell leukemia/lymphoma on hyperCVAD/MTX and ara-C: literature review and our institutional treatment approach Clin Case Rep 2016; 4(1):67-71. PMID: 26783439. Full Text

Singh J, Olle B, Suhail H, Felicella MM, and Giri S. Metformin-induced mitochondrial function and ABCD2 up regulation in X-linked adrenoleukodystrophy involves AMP activated protein kinase J Neurochem 2016;PMID: 26849413. Article Request Form

Smith SC, Trpkov K, Chen YB, Mehra R, Sirohi D, Ohe C, Cani AK, Hovelson DH, Omata K, McHugh JB, Jochum W, Colecchia M, Amin M, Divatia MK, Hes O, Menon S, Werneck da Cunha I, Tripodi S, Brimo F, Gill AJ, Osunkoya AO, Magi-Galluzzi C, Sibony M, Williamson SR, Nesi G, Picken MM, Maclean F, Agaimy A, Cheng L, Epstein JI, Reuter VE, Tickoo SK, Tomlins SA, and Amin MB. Tubulocystic carcinoma of the kidney with poorly differentiated foci: A frequent morphologic pattern of fumarate hydratase-deficient renal cell carcinoma Am J Surg Pathol 2016; 40(11):1457-1472. PMID: 27635946. Full Text

Sood A, Williamson SR, and Leavitt DA. Neuroendocrine tumor of the ureter: A zebra among horses J Endourol Case Rep 2016; 2(1):204-208. PMID: 27868098. Full Text

Suleyman G, Perri M, Vager D, Samuel L, Zervos MJ, Alangaden G, and Tibbetts RJ. Characterization of Salmonella Isangi possessing a CTX-M15 ESBL associated with an outbreak in a US Hospital Diagn Microbiol Infect Dis 2016;PMID: 27130476. Full Text

Suleyman G, Tibbetts R, Perri MB, Vager D, Xin Y, Reyes K, Samuel L, Chami E, Starr P, Pietsch J, Zervos MJ, and Alangaden G. Nosocomial Outbreak of a Novel Extended-Spectrum beta- Lactamase Salmonella enterica Serotype Isangi Among Surgical Patients Infect Control Hosp Epidemiol 2016:1-8. PMID: 27108715. Article Request Form

Williamson SR, and Cheng L. Clear cell renal cell tumors: Not all that is "clear" is cancer Urol Oncol 2016;PMID: 26988177. Full Text

Williamson SR. Renal oncocytoma with perinephric fat invasion Int J Surg Pathol 2016;PMID: 27170678. Full Text

Williamson SR. What is the malignant potential of clear cell papillary renal cell carcinoma? Urol Oncol 2016;PMID: 27364705. Full Text

Williamson SR, Delahunt B, Magi-Galluzzi C, Algaba F, Egevad L, Ulbright TM, Tickoo SK, Srigley JR, Epstein JI, and Berney DM. The WHO 2016 classification of testicular germ cell tumours: A review and update from the ISUP testis consultation panel Histopathology 2016;PMID: 27747907. Full Text

105 Williamson SR, Eble JN, and Palanisamy N. Sclerosing TFEB rearrangement renal cell carcinoma: A recurring histologic pattern Hum Pathol 2016;PMID: 27864122. Full Text

Williamson SR, Grignon DJ, Cheng L, Favazza L, Gondim DD, Carskadon S, Gupta NS, Chitale DA, Kalyana- Sundaram S, and Palanisamy N. Renal cell carcinoma with chromosome 6p amplification including the tfeb gene: A novel mechanism of tumor pathogenesis? Am J Surg Pathol 2016;PMID: 28009604. Full text

Worsham MJ, Chen KM, Datta I, Stephen JK, Chitale D, Gothard A, and Divine G. The biological significance of methylome differences in human papilloma virus associated head and neck cancer Oncology Letters 2016; 12(6):4949-4956. PMID: Not assigned. Article Request Form

Yates SG, Smith S, Tharpe W, Shen YM, and Sarode R. Can an anti-Xa assay for low-molecular- weight heparin be used to assess the presence of rivaroxaban? Transfus Apher Sci 2016; 55(2):212- 215. PMID: 27377884. Full Text

Zhang L, Yang M, Mayer T, Johnstone B, Les C, Frisch N, Parsons T, Mi QS, and Gibson G. Use of MicroRNA biomarkers to distinguish enchondroma from low-grade chondrosarcoma Connect Tissue Res 2016:1-7. PMID: 27267924. Article Request Form

106 PEDIATRICS

Connolly MD, Zervos MJ, Barone CJ, 2nd, Johnson CC, and Joseph CL. The mental health of transgender youth: Advances in understanding J Adolesc Health 2016; 59(5):489-495. PMID: 27544457. Full Text

Neonatology

Rito DC, Viehl LT, Buchanan PM, Haridas S, and Koenig JM. Augmented th17-type immune responses in preterm neonates exposed to histologic chorioamnionitis Pediatr Res 2016;PMID: 27870827. Article Request Form

107 PHARMACY Athans V, Kenney RM, Wong J, and Davis SL. Outpatient use of ceftaroline fosamil versus vancomycin for osteoarticular infection: a matched cohort study J Antimicrob Chemother 2016;PMID: 27530754. Full Text

Beyer A, Ganti B, Majkrzak A, and Theyyunni N. A perfect storm: Tyrosine kinase inhibitor- associated polymorphic ventricular tachycardia J Emerg Med 2016;PMID: 28007361. Full text

Carreno JJ, Kenney RM, Divine G, Vazquez JA, and Davis SL. Randomized controlled trial to determine the efficacy of early switch from vancomycin to vancomycin alternatives as a strategy to prevent nephrotoxicity in patients with multiple risk factors for adverse renal outcomes (STOP-NT) Ann Pharmacother 2016;PMID: 27838680. Full Text

Chackunkal E, Dhanapal Vogel V, Grycki M, and Kostoff D. Improving adherence to the Epic Beacon ambulatory workflow J Oncol Pharm Pract 2016;PMID: 26988246. Full Text

Claeys KC, Lagnf AM, Hallesy JA, Compton MT, Gravelin AL, Davis SL, and Rybak MJ. Pneumonia caused by methicillin-resistant staphylococcus aureus - does vancomycin heteroresistance matter? Antimicrob Agents Chemother 2016;PMID: 26729497. Full Text

Claeys KC, Zasowski EJ, Casapao AM, Lagnf AM, Nagel JL, Nguyen CT, Hallesy JA, Compton MT, Kaye KS, Levine DP, Davis SL, and Rybak MJ. Propensity matched analysis of early daptomycin versus vancomycin for methicillin- resistant s. Aureus bloodstream infections: Daptomycin improves outcomes regardless of vancomycin MIC Antimicrob Agents Chemother 2016;PMID: 27431221. Full Text

Farhat NM, Hutchinson LS, and Peters M. Elevated international normalized ratio values in a patient receiving warfarin and ceftaroline Am J Health Syst Pharm 2016; 73(2):56-59. PMID: 26721534. Full Text

Flynt LK, Veve MP, Samuel LP, and Tibbetts RJ. Ceftolozane-tazobactam susceptibility testing of Pseudomonas aeruginosa: a comparison of Etest to broth microdilution J Clin Microbiol 2016;PMID: 27795348. Article Request Form

Ganti BR, Marini BL, Nagel J, Bixby D, and Perissinotti AJ. Impact of antibacterial prophylaxis during reinduction chemotherapy for relapse/refractory acute myeloid leukemia Support Care Cancer 2016;PMID: 27738797. Full Text

Hencken L, To L, Ly N, and Morgan JA. Serotonin syndrome following methylene blue administration for vasoplegic syndrome J Card Surg 2016; 31(4):208-210. PMID: 26934199. Full Text

Horng M, Mohammad I, Smith ZR, Awdish RL, and Cajigas HR. Inhaled iloprost for chronic thromboembolic pulmonary hypertension (CTEPH) during pregnancy: a case report Pharmacotherapy 2016;PMID: 27341074. Full Text

Kenney RM, Cole KA, Perri MB, Dumkow LE, Samuel LP, Zervos MJ, and Davis SL. Reply to "urinary tract infections: Resistance is futile" Antimicrob Agents Chemother 2016; 60(4):2598. PMID: 27016558. Full Text

Smith AL, Garwood CL, Bailey T, DeCator D, Elder J, Green A, Kostoff D, Lucarotti RL, MacDonald NC, Malburg D, Ottney A, Remington TL, and Shuster J. State affiliate initiative to advance ambulatory care practice Am J Health Syst Pharm 2016; 73(23):1909-1914. PMID: 27864196. Full Text

Smith ZR, Makowski CT, and Awdish RL. Treatment of patients with chronic thrombo embolic pulmonary hypertension: focus on riociguat Ther Clin Risk Manag 2016; 12:957-964. PMID: 27354811. Full Text

Suleyman G, Kenney R, Zervos MJ, and Weinmann A. Safety and efficacy of outpatient parenteral antibiotic therapy in an academic infectious disease clinic J Clin Pharm Ther 2016;PMID: 27747899. Full Text

Venker BT, Ganti BR, Lin H, Lee ED, Nunley RM, and Gage BF. Safety and efficacy of new 108 anticoagulants for the prevention of venous thromboembolism after hip and knee arthroplasty: A meta-analysis J Arthroplasty 2016;PMID: 27823844. Full Text

Veve MP, Wagner JL, Kenney RM, Grunwald JL, and Davis SL. Comparison of fosfomycin to ertapenem for outpatient or step-down therapy of extended-spectrum beta-lactamase urinary tract infections Int J Antimicrob Agents 2016;PMID: 27234673. Full Text

Wagner JL, Kenney RM, Vazquez JA, Ghanem TA, and Davis SL. Surgical prophylaxis with gram- negative activity for reduction of surgical site infections after microvascular reconstruction for head and neck cancer Head Neck 2016;PMID: 27458902. Full Text

Zasowski EJ, Claeys KC, Lagnf AM, Davis SL, and Rybak MJ. Time is of the essence: The impact of delayed antibiotic therapy on patient outcomes in hospital-onset enterococcal bloodstream infections Clin Infect Dis 2016;PMID: 26945013. Full Text

Zasowski EJ, Trinh TD, Claeys KC, Casapao AM, Sabagha N, Lagnf AM, Klinker KP, Davis SL, and Rybak MJ. A multicenter observational study of ceftaroline fosamil for methicillin-resistant staphylococcus aureus bloodstream infections Antimicrob Agents Chemother 2016;PMID: 27895012. Full Text

109 PUBLIC HEALTH SCIENCES

Ahmedani BK, Peterson EL, Wells KE, Henein F, and Williams LK. Long-term management of low back pain with opioids and non-steroidal anti-inflammatory drugs in a health system Am J Prev Med 2016;PMID: 26970664. Full Text

Al Feghali KA, Robbins JR, Mahan M, Burmeister C, Khan NT, Rasool N, Munkarah A, and Elshaikh MA. Predictive capacity of 3 comorbidity indices in estimating survival endpoints in women with early-stage endometrial carcinoma Int J Gynecol Cancer 2016;PMID: 27488218. Full Text

Arena SK, Bacyinski A, Simon L, and Peterson EL. Aneroid blood pressure manometer calibration rates of devices used in home health Home Healthc Now 2016; 34(1):23-28. PMID: 26645840. Article Request Form

Arena SK, Simon L, and Peterson EL. Aneroid blood pressure manometer calibration rates in physical therapy curricula: A descriptive study Cardiopulm Phys Ther J 2016; 27(2):56-61. PMID: Not assigned. Full Text

Azuh O, Gammon H, Burmeister C, Frega D, Nerenz D, DiGiovine B, and Siddiqui A. Benefits of early active mobility in the medical intensive care unit - a pilot study Am J Med 2016;PMID: 27107920. Full Text

Badano A, Wang J, Boynton P, Le Callet P, Cheng WC, Deroo D, Flynn MJ, Matsui T, Penczek J, Revie C, Samei E, Steven PM, Swiderski S, Van Hoey G, Yamaguchi M, Hasegawa M, and Nagy BV. Technical note: Gray tracking in medical color displays-a report of task group 196 Med Phys 2016; 43(7):4017. PMID: 27370120. Article Request Form

Bansal N, Szpiro A, Masoudi F, Greenlee RT, Smith DH, Magid DJ, Gurwitz JH, Reynolds K, Tabada GH, Sung SH, Dighe A, Cassidy-Bushrow A, Garcia-Montilla R, Hammill S, Hayes J, Kadish A, Sharma P, Varosy P, Vidaillet H, and Go AS. Kidney function and appropriateness of device therapies in adults with implantable cardioverter defibrillators Heart 2016;PMID: 27742796. Full Text

Baptist AP, Islam N, and Joseph CL. Technology-based interventions for asthma-can they help decrease health disparities? J Allergy Clin Immunol Pract 2016;PMID: 27286777. Full Text

Baumer TG, Chan D, Mende V, Dischler J, Zauel R, van Holsbeeck M, Siegal DS, Divine G, Moutzouros V, and Bey MJ. Effects of rotator cuff pathology and physical therapy on in vivo shoulder motion and clinical outcomes in patients with a symptomatic full-thickness rotator cuff tear Orthop J Sports Med 2016; 4(9)PMID: 27734020. Full Text

Belsky JB, Morris DC, Bouchebl R, Filbin MR, Bobbitt KR, Jaehne AK, and Rivers EP. Plasma levels of F-actin and F:G-actin ratio as potential new biomarkers in patients with septic shock Biomarkers 2016:1-6. PMID: 26754286. Article Request Form

Bertran EA, Berlie HD, Taylor A, Divine G, and Jaber LA. Diagnostic performance of HbA for diabetes in Arab vs. European populations: a systematic review and meta-analysis Diabet Med 2016;PMID: 26996656. Full Text

Bossick AS, Peters RM, Burmeister C, Kakumanu N, Shill JE, and Cassidy-Bushrow AE. Antenatal inflammation and gestational diabetes mellitus risk among pregnant African-American women J Reprod Immunol 2016; 115:1-5. PMID: 27061480. Full Text

Cajigal S, Wells KE, Peterson EL, Ahmedani BK, Yang JJ, Kumar R, Burchard EG, and Williams LK. Predictive properties of the asthma control test and its component questions for severe asthma exacerbations J Allergy Clin Immunol Pract 2016;PMID: 27544712. Full Text

Carreno JJ, Kenney RM, Divine G, Vazquez JA, and Davis SL. Randomized controlled trial to determine the efficacy of early switch from vancomycin to vancomycin alternatives as a strategy to prevent nephrotoxicity in patients with multiple risk factors for adverse renal outcomes (STOP-NT) Ann Pharmacother 2016;PMID: 27838680. Full Text

110 Cassidy-Bushrow AE, Wegienka G, Havstad S, Levin AM, Lynch SV, Ownby DR, Rundle AG, Woodcroft KJ, Zoratti EM, and Johnson CC. Race-specific association of caesarean-section delivery with body size at age 2 years Ethn Dis 2016; 26(1):61-68. PMID: 26843797. Article Request Form

Cassidy-Bushrow AE, Peters RM, Burmeister C, Bielak LF, and Johnson DA. Neighborhood- level poverty at menarche and prepregnancy obesity in African-American women J Pregnancy 2016; 2016:4769121. PMID: 27418977. Full Text

Castillo JJ, Glezerman IG, Boklage SH, Chiodo J, 3rd, Tidwell BA, Lamerato LE, and Schulman KL. The occurrence of hyponatremia and its importance as a prognostic factor in a cross-section of cancer patients BMC Cancer 2016; 16(1):564. PMID: 27473121. Full Text

Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA, Morozova O, Newton Y, Radenbaugh A, Pagnotta SM, Anjum S, Wang J, Manyam G, Zoppoli P, Ling S, Rao AA, Grifford M, Cherniack AD, Zhang H, Poisson L, Carlotti CG, Jr., Tirapelli DP, Rao A, Mikkelsen T, Lau CC, Yung WK, Rabadan R, Huse J, Brat DJ, Lehman NL, Barnholtz-Sloan JS, Zheng S, Hess K, Rao G, Meyerson M, Beroukhim R, Cooper L, Akbani R, Wrensch M, Haussler D, Aldape KD, Laird PW, Gutmann DH, Noushmehr H, Iavarone A, and Verhaak RG. Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma Cell 2016; 164(3):550-563. PMID: 26824661. Article Request Form

Connolly MD, Zervos MJ, Barone CJ, 2nd, Johnson CC, and Joseph CL. The mental health of transgender youth: Advances in understanding J Adolesc Health 2016; 59(5):489-495. PMID: 27544457. Full Text

Crawford EL, Levin A, Safi F, Lu M, Baugh A, Zhang X, Yeo J, Khuder SA, Boulos AM, Nana-Sinkam P, Massion PP, Arenberg DA, Midthun D, Mazzone PJ, Nathan SD, Wainz R, Silvestri G, Tita J, and Willey JC. Lung cancer risk test trial: study design, participant baseline characteristics, bronchoscopy safety, and establishment of a biospecimen repository BMC Pulm Med 2016; 16(1):16. PMID: 26801409. Full Text

El-Refai M, Hrobowski T, Peterson EL, Wells K, Spertus JA, Williams LK, and Lanfear DE. Race and association of angiotensin converting enzyme/angiotensin receptor blocker exposure with outcome in heart failure J Cardiovasc Med (Hagerstown) 2015; 16(9):591-596. PMID: 24842464. Full Text

Foster MA, Xing J, Moorman AC, Boscarino J, Gordon SC, Lu M, Rupp L, Schmidt MA, Trinacty CM, Xu F, Holmberg SD, and Spradling PR. Frequency of and factors associated with receipt of liver-related specialty care among patients with hepatitis c in the chronic hepatitis cohort study Dig Dis Sci 2016;PMID: 27510752. Full Text

Fu AZ, Tsai HT, Haque R, Ulcickas Yood M, Van Den Eeden SK, Cassidy-Bushrow AE, Zhou Y, Keating NL, Smith MR, Aaronson DS, and Potosky AL. Use of androgen deprivation therapy as salvage treatment after primary therapy for clinically localized prostate cancer World J Urol 2016;PMID: 27084777. Full Text

Fu AZ, Tsai HT, Haque R, Ulcickas Yood M, Cassidy-Bushrow AE, Van Den Eeden SK, Keating NL, Smith MR, Zhou Y, Aaronson DS, and Potosky AL. Mortality and androgen-deprivation therapy as salvage treatment for biochemical recurrence after primary therapy for clinically localized prostate cancer J Urol 2016;PMID: 28007467. Full text

Fujimura KE, Sitarik AR, Havstad S, Lin DL, Levan S, Fadrosh D, Panzer AR, LaMere B, Rackaityte E, Lukacs NW, Wegienka G, Boushey HA, Ownby DR, Zoratti EM, Levin AM, Johnson CC, and Lynch SV. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation Nat Med 2016;PMID: 27618652. Full Text

Gammon HM, Shelton CB, Siegert C, Dawson C, Sexton E, Burmeister C, Gnam G, and Siddiqui A. Self-turning for pressure injury prevention Wound Medicine 2016; 12:15-18. PMID: Not assigned Article Request Form

111 Garcia-Rodriguez L, Jones L, Chen KM, Datta I, Divine G, and Worsham MJ. Causal network analysis of head and neck keloid tissue identifies potential master regulators Laryngoscope 2016;PMID: 26990118. Full Text

Goyal N, Taylor AR, and Rivers EP. Relationship between central and peripheral venous oxygen saturation and lactate levels: A prospective study J Emerg Med 2016;PMID: 27210904. Full Text

Greenlee H, Neugut AI, Falci L, Hillyer GC, Buono D, Mandelblatt JS, Roh JM, Ergas IJ, Kwan ML, Lee M, Tsai WY, Shi Z, Lamerato L, Kushi LH, and Hershman DL. Association between complementary and alternative medicine use and breast cancer chemotherapy initiation: The breast cancer quality of care (bqual) study JAMA Oncol 2016;PMID: 27243607. Full Text

Gu X, Xu J, Zhu L, Bryson T, Yang XP, Peterson E, and Harding P. Prostaglandin e2 reduces cardiac contractility via ep3 receptor Circ Heart Fail 2016; 9(8)PMID: 27502370. Full Text

Gusev A, Shi H, Kichaev G, Pomerantz M, Li F, Long HW, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B, Isaacs WB, Zheng W, Pettaway CA, Yeboah ED, Tettey Y, Biritwum RB, Adjei AA, Tay E, Truelove A, Niwa S, Chokkalingam AP, John EM, Murphy AB, Signorello LB, Carpten J, Leske MC, Wu SY, Hennis AJ, Neslund-Dudas C, Hsing AW, Chu L, Goodman PJ, Klein EA, Witte JS, Casey G, Kaggwa S, Cook MB, Stram DO, Blot WJ, Eeles RA, Easton D, Kote-Jarai Z, Al Olama AA, Benlloch S, Muir K, Giles GG, Southey MC, Fitzgerald LM, Gronberg H, Wiklund F, Aly M, Henderson BE, Schleutker J, Wahlfors T, Tammela TL, Nordestgaard BG, Key TJ, Travis RC, Neal DE, Donovan JL, Hamdy FC, Pharoah P, Pashayan N, Khaw KT, Stanford JL, Thibodeau SN, McDonnell SK, Schaid DJ, Maier C, Vogel W, Luedeke M, Herkommer K, Kibel AS, Cybulski C, Wokolorczyk D, Kluzniak W, Cannon- Albright L, Teerlink C, Brenner H, Dieffenbach AK, Arndt V, Park JY, Sellers TA, Lin HY, Slavov C, Kaneva R, Mitev V, Batra J, Spurdle A, Clements JA, Teixeira MR, Pandha H, Michael A, Paulo P, Maia S, Kierzek A, Conti DV, Albanes D, Berg C, Berndt SI, Campa D, Crawford ED, Diver WR, Gapstur SM, Gaziano JM, Giovannucci E, Hoover R, Hunter DJ, Johansson M, Kraft P, Le Marchand L, Lindstrom S, Navarro C, Overvad K, Riboli E, Siddiq A, Stevens VL, Trichopoulos D, Vineis P, Yeager M, Trynka G, Raychaudhuri S, Schumacher FR, Price AL, Freedman ML, Haiman CA, and Pasaniuc B. Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation Nat Commun 2016; 7:10979. PMID: 27052111. Full Text

Han Y, Rand KA, Hazelett DJ, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B, Isaacs WB, Stanford JL, Zheng W, Schumacher FR, Berndt SI, Wang Z, Xu J, Rohland N, Reich D, Tandon A, Pasaniuc B, Allen A, Quinque D, Mallick S, Notani D, Rosenfeld MG, Jayani RS, Kolb S, Gapstur SM, Stevens VL, Pettaway CA, Yeboah ED, Tettey Y, Biritwum RB, Adjei AA, Tay E, Truelove A, Niwa S, Chokkalingam AP, John EM, Murphy AB, Signorello LB, Carpten J, Leske MC, Wu SY, Hennis AJ, Neslund-Dudas C, Hsing AW, Chu L, Goodman PJ, Klein EA, Zheng SL, Witte JS, Casey G, Lubwama A, Pooler LC, Sheng X, Coetzee GA, Cook MB, Chanock SJ, Stram DO, Watya S, Blot WJ, Conti DV, Henderson BE, and Haiman CA. Prostate cancer susceptibility in men of African ancestry at 8q24 J Natl Cancer Inst 2016; 108(7)PMID: 26823525. Full Text

Henein F, Prabhakar D, Peterson EL, Williams LK, and Ahmedani BK. A prospective study of antidepressant adherence and suicidal ideation among adults Prim Care Companion CNS Disord 2016; 18(6)PMID: 27907275. Article Request Form

Hershman DL, Kushi LH, Hillyer GC, Coromilas E, Buono D, Lamerato L, Bovbjerg DH, Mandelblatt JS, Tsai WY, Zhong X, Jacobson JS, Wright JD, and Neugut AI. Psychosocial factors related to non- persistence withadjuvant endocrine therapy among women with breast cancer: the Breast Cancer Quality of Care Study (BQUAL) Breast Cancer Res Treat 2016;PMID: 27086286. Full Text

Hung J, Taylor AR, Divine GW, Hafron JM, and Hwang C. The effect of time to castration resistance on outcomes with abiraterone and enzalutamide in metastatic prostate cancer Clin Genitourin Cancer 2016;PMID: 27157640.Full Text

Isrow D, Burmeister C, Hanna RK, and Elshaikh MA. Survival endpoints for young women with early stage uterine endometrioid carcinoma: a matched analysis Eur J Obstet Gynecol Reprod Biol 2016; 207:115-120. PMID: 27838535. Full Text

112 Jain T, Nowak R, Hudson M, Frisoli T, Jacobsen G, and McCord J. Short- and long-term prognostic utility of the HEART score in patients evaluated in the emergency department for possible acute coronary syndrome Crit Pathw Cardiol 2016; 15(2):40-45. PMID: 27183252. Full Text

Jesse MT, Rubinstein E, Eshelman A, Wee C, Tankasala M, Li J, and Abouljoud M. Lifestyle and self- management by those who live it: Patients engaging patients in a chronic disease model Perm J 2016; 20(3)PMID: 27455056. Article Request Form

Jiang W, Finniss S, Cazacu S, Xiang C, Brodie Z, Mikkelsen T, Poisson L, Shackelford DB, and Brodie C. Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma Oncotarget 2016;PMID: 27486821. Full Text

Johnson CC, and Ownby DR. Allergies and asthma: Do atopic disorders result from inadequate immune homeostasis arising from infant gut dysbiosis? Expert Rev Clin Immunol 2016;PMID: 26776722. Article Request Form

Johnson CC, and Ownby DR. The infant gut bacterial microbiota and risk of pediatric asthma and allergic diseases Transl Res 2016;PMID: 27469270. Full Text

Jones LR, Greene J, Chen KM, Divine G, Chitale D, Shah V, Datta I, and Worsham MJ. Biological significance of genome-wide DNA methylation profiles in keloids Laryngoscope 2016;PMID: 27312686. Full Text

Joseph CL, Zoratti EM, Ownby DR, Havstad S, Nicholas C, Nageotte C, Misiak R, Enberg R, Ezell J, and Johnson CC. Exploring racial differences in IgE-mediated food allergy in the WHEALS birth cohort Ann Allergy Asthma Immunol 2016;PMID: 26837607. Full Text

Joseph CLM, Ownby DR, Zoratti E, Johnson D, Considine S, Bourgeois R, Melkonian C, Miree C, Cole Johnson C, and Lu M. Recruitment experience for a pragmatic randomized controlled trial: Using EMR initiatives and minimizing research infrastructure Clin Res Regul Aff 2016:1-8. PMID: Not assigned. Article Request Form

Kessler MD, Yerges-Armstrong L, Taub MA, Shetty AC, Maloney K, Jeng LJ, Ruczinski I, Levin AM, Williams LK, Beaty TH, Mathias RA, Barnes KC, and O'Connor TD. Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry Nat Commun 2016; 7:12521. PMID: 27725664. Full Text

Krasnick BA, Nathanson SD, Arbabi CN, Chitale DA, and Peterson EL. The predictive value of increased sentinel lymph node volume in breast cancer Surg Oncol 2016; 25(3):321-325. PMID: 27566039. Full Text

Kaljee LM, Kilgore P, Prentiss T, Lamerato L, Moreno D, Arshad S, and Zervos M. 'You need to be an advocate for yourself': Factors associated with decision-making regarding influenza and pneumococcal vaccine use among U.S. older adults from within a large metropolitan health system Hum Vaccin Immunother 2016:0. PMID: 27625007. Article Request Form

Levin AM, Sitarik AR, Havstad SL, Fujimura KE, Wegienka G, Cassidy-Bushrow AE, Kim H, Zoratti EM, Lukacs NW, Boushey HA, Ownby DR, Lynch SV, and Johnson CC. Joint effects of pregnancy, sociocultural, and environmental factors on early life gut microbiome structure and diversity Sci Rep 2016; 6:31775. PMID: 27558272. Full Text

Li J, Gordon SC, Rupp LB, Zhang T, Trudeau S, Holmberg SD, Moorman AC, Spradling PR, Teshale EH, Boscarino JA, Daida YG, Schmidt MA, and Lu M. Long-term progression of viral load and serum markers of fibrosis among treated and untreated patients with chronic hepatitis B J Gastroenterol Hepatol 2016;PMID: 27888529. Full Text

Lin JC, Kabbani LS, Peterson EL, Masabni K, Morgan JA, Brooks S, Wertella KP, and Paone G. Clinical utility of carotid duplex ultrasound prior to cardiac surgery J Vasc Surg 2016; 63(3):710-714. PMID: 26916583. Full Text

113 Lindquist KJ, Paris PL, Hoffmann TJ, Cardin NJ, Kazma R, Mefford JA, Simko JP, Ngo V, Chen Y, Levin AM, Chitale D, Helfand BT, Catalona WJ, Rybicki BA, and Witte JS. Mutational landscape of aggressive prostate tumors in African American men Cancer Res 2016;PMID: 26921337. Full Text

Liu XS, Fan BY, Pan WL, Li C, Levin AM, Wang X, Zhang RL, Zervos TM, Hu J, Zhang XM, Chopp M, and Zhang ZG. Identification of miRNomes associated with adult neurogenesis after stroke using Argonaute 2-based RNA sequencing RNA Biol 2016:0. PMID: 27315491. Article Request Form

Lu M, Li J, Zhang T, Rupp LB, Trudeau S, Holmberg SD, Moorman AC, Spradling PR, Teshale EH, Xu F, Boscarino JA, Schmidt MA, Vijayadeva V, and Gordon SC. Long-term reduction in liver fibrosis, based on serum biomarkers, in patients with sustained viral responses to HCV treatment Clin Gastroenterol Hepatol 2016;PMID: 26804385. Full Text

Lu M, Li J, Rupp LB, Holmberg SD, Moorman AC, Spradling PR, Teshale EH, Zhou Y, Boscarino JA, Schmidt MA, Lamerato LE, Trinacty C, Trudeau S, and Gordon SC. Hepatitis C treatment failure is associated with increased risk of hepatocellular carcinoma J Viral Hepat 2016;PMID: 27028626. Full Text

Mathias RA, Taub MA, Gignoux CR, Fu W, Musharoff S, O'Connor TD, Vergara C, Torgerson DG, Pino- Yanes M, Shringarpure SS, Huang L, Rafaels N, Boorgula MP, Johnston HR, Ortega VE, Levin AM, Song W, Torres R, Padhukasahasram B, Eng C, Mejia-Mejia DA, Ferguson T, Qin ZS, Scott AF, Yazdanbakhsh M, Wilson JG, Marrugo J, Lange LA, Kumar R, Avila PC, Williams LK, Watson H, Ware LB, Olopade C, Olopade O, Oliveira R, Ober C, Nicolae DL, Meyers D, Mayorga A, Knight-Madden J, Hartert T, Hansel NN, Foreman MG, Ford JG, Faruque MU, Dunston GM, Caraballo L, Burchard EG, Bleecker E, Araujo MI, Herrera-Paz EF, Gietzen K, Grus WE, Bamshad M, Bustamante CD, Kenny EE, Hernandez RD, Beaty TH, Ruczinski I, Akey J, and Barnes KC. A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome Nat Commun 2016; 7:12522. PMID: 27725671. Full Text

Mawri S, Michaels A, Gibbs J, Shah S, Rao S, Kugelmass A, Lingam N, Arida M, Jacobsen G, Rowlandson I, Iyer K, Khandelwal A, and McCord J. The comparison of physician to computer interpreted electrocardiograms on ST-elevation myocardial infarction door-to-balloon times Crit Pathw Cardiol 2016; 15(1):22-25. PMID: 26881816. Full Text

Miller AJ, Bobian M, Peterson E, and Deeb R. Bleeding risk associated with resection of the middle turbinate during functional endoscopic sinus surgery Am J Rhinol Allergy 2016; 30(2):140-142. PMID: 26980395. Article Request Form

Miller JB, Lewandowski C, Wira CR, Taylor A, Burmeister C, and Welch R. Volume of plasma expansion and functional outcomes in stroke Neurocrit Care 2016;PMID: 27629275. Full Text

Modh A, Ghanem AI, Burmeister C, Rasool N, and Elshaikh MA. Trends in the utilization of adjuvant vaginal brachytherapy in women with early-stage endometrial carcinoma: Results of an updated period analysis of SEER data Brachytherapy 2016;PMID: 27475480. Full Text

Moorman AC, Tong X, Spradling PR, Rupp LB, Gordon SC, Lu M, Teshale EH, Boscarino JA, Trinacty CM, Schmidt MA, Xu F, and Holmberg SD. Prevalence of renal impairment and associated conditions among hcv-infected persons in the chronic hepatitis cohort study (CHeCS) Dig Dis Sci 2016;PMID: 27216163. Full Text

Munkarah A, Mert I, Chhina J, Hamid S, Poisson L, Hensley-Alford S, Giri S, and Rattan R. Targeting of free fatty acid receptor 1 in EOC: A novel strategy to restrict the adipocyte-EOC dependence Gynecol Oncol 2016; 141(1):72-79. PMID: 27016232. Full Text

Neugut AI, Hillyer GC, Kushi LH, Lamerato L, Buono DL, Nathanson SD, Bovbjerg DH, Mandelblatt JS, Tsai WY, Jacobson JS, and Hershman DL. A prospective cohort study of early discontinuation of adjuvant chemotherapy in women with breast cancer: the breast cancer quality of care study (BQUAL) 114 Breast Cancer Res Treat 2016;PMID: 27287779. Full Text

Ownby D, and Johnson CC. Recent understandings of pet allergies F1000Res 2016; 5PMID: 26918180. Full Text

Ownby DR, and Johnson CC. Dogs, cats and asthma: Will we ever really know the true risks and benefits? J Allergy Clin Immunol 2016;PMID: 27670242. Full Text

Petraszko A, Siegal D, Flynn M, Rao SD, Peterson E, and van Holsbeeck M. The advantages of tomosynthesis for evaluating bisphosphonate-related atypical femur fractures compared to radiography Skeletal Radiol 2016;PMID: 26861160. Full Text

Petraszko A, Siegal D, Flynn M, Rao SD, Peterson E, and van Holsbeeck M. Erratum to: The advantages of tomosynthesis for evaluating bisphosphonate-related atypical femur fractures compared to radiography Skeletal Radiol 2016;PMID: 26899141. Full Text

Petrie JG, Ohmit SE, Cheng CK, Martin ET, Malosh RE, Lauring AS, Lamerato LE, Reyes KC, Flannery B, Ferdinands JM, and Monto AS. Influenza vaccine effectiveness against antigenically drifted influenza higher than expected in hospitalized adults: 2014-2015 Clin Infect Dis 2016;PMID: 27369320. Full Text

Qiu S, Divine GW, Palnitkar S, Kulkarni P, Guthrie TS, Honasoge M, and Rao SD. Bone structure and turnover status in postmenopausal women with atypical femur fracture after prolonged bisphosphonate therapy Calcif Tissue Int 2016;PMID: 28013363. Full text

Rand KA, Song C, Dean E, Serie DJ, Curtin K, Sheng X, Hu D, Huff CA, Bernal-Mizrachi L, Tomasson MH, Ailwadhi S, Singhal S, Pawlish KS, Peters ES, CH BL, Stram A, Van Den Berg DJ, Edlund CK, Conti DV, Zimmerman TM, Hwang AE, Huntsman S, Graff JJ, Nooka A, Kong Y, Pregja SL, Berndt SI, Blot WJ, Carpten JD, Casey G, Chu LW, Diver WR, Stevens VL, Lieber MR, Goodman PJ, Hennis AJ, Hsing AW, Mehta J, Kittles RA, Kolb S, Klein EA, Leske CM, Murphy AB, Nemesure B, Neslund- Dudas C, Strom SS, Vij R, Rybicki BA, Stanford JL, Signorello L, Witte JS, Ambrosone CB, Bhatti P, John EM, Bernstein L, Zheng W, Olshan AF, Hu JJ, Ziegler RG, Nyante SJ, Bandera EV, Birmann BM, Ingles SA, Press MF, Atanackovic D, Glenn M, Cannon-Albright L, Jones B, Tricot G, Martin TG, Kumar SK, Wolf JL, Deming SL, Rothman N, Brooks-Wilson A, Rajkumar SV, Kolonel LN, Chanock SJ, Slager SL, Severson RK, Janakirman N, Terebelo HJ, Brown EE, De Roos AJ, Mohrbacher A, Colditz GA, Giles GG, Spinelli JJ, Chiu BC, Munshi NC, Anderson KC, Levy J, Zonder JA, Orlowski RZ, Lonial S, Camp NJ, Vachon CM, Ziv E, Stram DO, Hazelett DJ, and Cozen W. A meta-analysis of multiple myeloma risk regions in African and European ancestry populations identifies putatively functional loci Cancer Epidemiol Biomarkers Prev 2016;PMID: 27587788. Article Request Form

Ren Y, Janic B, Kutskill K, Peterson EL, and Carretero OA. Mechanisms of connecting tubule glomerular feedback enhancement by aldosterone Am J Physiol Renal Physiol 2016:ajprenal.00076.02016. PMID: 27413197. Full Text

Reynolds K, Go AS, Leong TK, Boudreau DM, Cassidy-Bushrow AE, Fortmann SP, Goldberg RJ, Gurwitz JH, Magid DJ, Margolis KL, McNeal CJ, Newton KM, Novotny R, Quesenberry CP, Jr., Rosamond WD, Smith DH, VanWormer JJ, Vupputuri S, Waring SC, Williams MS, and Sidney S. Trends in incidence of hospitalized acute myocardial infarction in the cardiovascular research network (CVRN) Am J Med 2016;PMID: 27751900. Full Text

Rybicki BA, Rundle A, Kryvenko ON, Mitrache N, Do KC, Jankowski M, Chitale DA, Trudeau S, Belinsky SA, and Tang D. Methylation in benign prostate and risk of disease progression in men subsequently diagnosed with prostate cancer Int J Cancer 2016;PMID: 26860439. Full Text

Salafia CM, Thomas DM, Roberts DJ, Straughen JK, Catalano PM, and Perez-Avilan G. First trimester detection of placental disease: Challenges and opportunities Am J Perinatol 2016; 33(13):1306-1312. PMID: 27490774. Article request form

Schiff L, Tsafrir Z, Aoun J, Taylor A, Theoharis E, and Eisenstein D. Quality of communication in

115 robotic surgery and surgical outcomes Jsls 2016; 20(3)PMID: 27493469. Full Text

Schulman KL, Lamerato LE, Dalal MR, Sung J, Jhaveri M, Koren A, Mallya UG, and Foody JM. Development and validation of algorithms to identify statin intolerance in a US administrative database Value Health 2016; 19(6):852- 860. PMID: 27712714. Full Text

Schwartz AG, Lusk CM, Wenzlaff AS, Watza D, Pandolfi S, Mantha L, Cote ML, Soubani AO, Walworth G, Wozniak A, Neslund-Dudas C, Ardisana AA, Flynn MJ, Song T, Spizarny DL, Kvale PA, Chapman RA, and Gadgeel SM. Risk of lung cancer associated with COPD phenotype based on quantitative image analysis Cancer Epidemiol Biomarkers Prev 2016; 25(9):1341-1347. PMID: 27383774. Article Request Form

Sleder A, Tackett S, Cerasale M, Mittal C, Isseh I, Radjef R, Taylor A, Farha R, Lupak O, Larkin D, Lamerato L, Divine G, Wisdom K, Baker-Genaw K, and O'Neill W. Socioeconomic and racial disparities: A case-control study of patients receiving transcatheter aortic valve replacement for severe aortic stenosis J Racial Ethn Health Disparities 2016;PMID: 28039604. Article Request Form

Spradling PR, Xing J, Rupp LB, Moorman AC, Gordon SC, Teshale ET, Lu M, Boscarino JA, Schmidt MA, Trinacty CM, and Holmberg SD. Distribution of disease phase, treatment prescription and severe liver disease among 1598 patients with chronic hepatitis B in the Chronic Hepatitis Cohort Study, 2006- 2013 Aliment Pharmacol Ther 2016;PMID: 27640985. Full Text

Suleyman G, Tibbetts R, Perri MB, Vager D, Xin Y, Reyes K, Samuel L, Chami E, Starr P, Pietsch J, Zervos MJ, and Alangaden G. Nosocomial Outbreak of a Novel Extended-Spectrum beta- Lactamase Salmonella enterica Serotype Isangi Among Surgical Patients Infect Control Hosp Epidemiol 2016:1-8. PMID: 27108715. Article Request Form

Takahashi K, Obeid J, Burmeister CS, Bruno DA, Kazimi MM, Yoshida A, Abouljoud MS, and Schnickel GT. Intrahepatic cholangiocarcinoma in the liver explant after liver transplantation: Histological differentiation and prognosis Ann Transplant 2016; 21:208-215. PMID: 27068242. Article Request Form

Teshale EH, Xing J, Moorman A, Holmberg SD, Spradling PR, Gordon SC, Rupp LB, Lu M, Boscarino JA, Trinacity CM, Schmidt MA, and Xu F. Higher all-cause hospitalization among patients with chronic hepatitis C: the Chronic Hepatitis Cohort Study (CHeCS), 2006-2013 J Viral Hepat 2016;PMID: 27186944. Full Text

Toubia T, Schiff L, Wegienka G, and Sangha R. Extended length of stay after robotic-assisted hysterectomy: Association with uterine weight and other risk factors J Gynecol Surg 2016; 32(1):19-23. PMID: Not assigned. Article Request Form

Tsafrir Z, Palmer M, Dahlman M, Nawfal AK, Aoun J, Taylor A, Fisher J, Theoharis E, and Eisenstein D. Long- term outcomes for different vaginal cuff closure techniques in robotic-assisted laparoscopic hysterectomy: A randomized controlled trial Eur J Obstet Gynecol Reprod Biol 2016; 210:7-12. PMID: 27923167. Full text

Valerio MA, Peterson EL, Wittich AR, and Joseph CL. Examining health literacy among urban African- American adolescents with asthma J Asthma 2016:0. PMID: 27359106. Full Text

Vance S, Burmeister C, Rasool N, Buekers T, and Elshaikh MA. Salvage versus adjuvant radiation treatment for women with early-stage endometrial carcinoma: A matched analysis Int J Gynecol Cancer 2016; 26(2):307-312. PMID: 26745700. Full Text

Venkat P, Chopp M, Zacharek A, Cui C, Zhang L, Li Q, Lu M, Zhang T, Liu A, and Chen J. White matter damage and glymphatic dysfunction in a model of vascular dementia in rats with no prior vascular pathologies Neurobiol Aging 2017; 50:96-106. PMID: 27940353. Full text

Wegienka G, Kaur H, Sangha R, and Cassidy-Bushrow AE. Maternal-cord blood vitamin d correlations vary by maternal levels J Pregnancy 2016; 2016:7474192. PMID: 27066272. Full Text

116 Wegienka G, Havstad S, Kim H, Zoratti E, Ownby D, Woodcroft KJ, and Johnson CC. Subgroup differences in the associations between dog exposure during the first year of life and early life allergic outcomes Clin Exp Allergy 2016;PMID: 27562398. Full Text

Wells KE, Cajigal S, Peterson EL, Ahmedani BK, Kumar R, Lanfear DE, Burchard EG, and Williams LK. Assessing differences in inhaled corticosteroid response by self-reported race-ethnicity and genetic ancestry among asthmatic subjects J Allergy Clin Immunol 2016;PMID: 27016472. Full Text

Woodhouse SJ, Peterson EL, Schmitt T, and Aquino S. Intraocular pressure in southern rockhopper (eudyptes chrysocome) and macaroni penguins (eudyptes chrysolophus): Evaluation of influencing factors J Zoo Wildl Med 2016; 47(1):223-235. PMID: 27010282. Article Request Form

Worsham MJ, Chen KM, Datta I, Stephen JK, Chitale D, Gothard A, and Divine G. The biological significance of methylome differences in human papilloma virus associated head and neck cancer Oncology Letters 2016; 12(6):4949-4956. PMID: Not assigned. Article Request Form

Xu Y, Burmeister C, Hanna RK, Munkarah A, and Elshaikh MA. Predictors of survival after recurrence in women with early-stage endometrial carcinoma Int J Gynecol Cancer 2016;PMID: 27206283. Full Text

Xu F, Moorman AC, Tong X, Gordon SC, Rupp LB, Lu M, Teshale EH, Spradling PR, Boscarino JA, Trinacty CM, Schmidt MA, and Holmberg SD. All-cause mortality and progression risks to hepatic decompensation and hepatocellular carcinoma in patients infected with hepatitis c virus Clin Infect Dis 2016; 62(3):289-297. PMID: 26417034. Full Text

Yang JJ, Li J, Williams LK, and Buu A. An efficient genome-wide association test for multivariate phenotypes based on the Fisher combination function BMC Bioinformatics 2016; 17(1):19. PMID: 26729364. Full Text

Yessayan L, Moore C, Lu M, and Yee J. Bone-specific alkaline phosphatase and bone turnover in African American hemodialysis patients Hemodial Int 2016;PMID: 27350216. Full Text

Zhang J, Zhang ZG, Li Y, Lu M, Zhang Y, Elias SB, and Chopp M. Thymosin beta4 promotes oligodendrogenesis in the demyelinating central nervous system Neurobiol Dis 2016; 88:85-95. PMID: 26805386. Full Text

Zhang L, Chopp M, Lu M, Zhang T, Winter S, Doppler E, Meier D, Chao L, Eapen A, Pabla P, and Gang Zhang Z. Cerebrolysin dose-dependently improves neurological outcome in rats after acute stroke: A prospective, randomized, blinded, and placebo-controlled study Int J Stroke 2016;PMID: 26763925. Article Request Form

Zhang L, Chopp M, Zhang Y, Xiong Y, Li C, Sadry N, Rhaleb I, Lu M, and Zhang ZG. Diabetes mellitus impairs cognitive function in middle-aged rats and neurological recovery in middle-aged rats after stroke Stroke 2016; 47(8):2112-2118. PMID: 27387991. Full Text

Zhang X, Crawford EL, Blomquist TM, Khuder SA, Yeo J, Levin AM, and Willey JC. Haplotype and diplotype analyses of variation in ERCC5 transcription cis-regulation in normal bronchial epithelial cells Physiol Genomics 2016; 48(7):537-543. PMID: 27235448. Full Text

Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorsky M, Zidzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkac I, Kooy A, van Schaik RH, Stehouwer CD, Logie L, Sutherland C, Klovins J, Pirags V, Hofman A, Stricker BH, Motsinger-Reif AA, Wagner MJ, Innocenti F, Hart LM, Holman RR, McCarthy MI, Hedderson MM, Palmer CN, Florez JC, Giacomini KM, and Pearson ER. Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin Nat Genet 2016;PMID: 27500523. Full Text

Zhu CS, Huang WY, Pinsky PF, Berg CD, Sherman M, Yu KJ, Carrick DM, Black A, Hoover R, Lenz P, Williams C, Hawkins L, Chaloux M, Yurgalevitch S, Mathew S, Miller A, Olivo V, Khan A, Pretzel SM, Multerer D, Beckmann P, Broski KG, and Freedman ND. The prostate, lung, colorectal and ovarian 117 cancer (PLCO) screening trial pathology tissue resource Cancer Epidemiol Biomarkers Prev 2016;PMID: 27635065. Article Request Form

Zhu L, Yang XP, Janic B, Rhaleb NE, Harding P, Nakagawa P, Peterson EL, and Carretero OA. Ac-SDKP suppresses TNFalpha-induced ICAM-1 expression in endothelial cells via inhibition of IkappaB kinase and NF- kappaB activation Am J Physiol Heart Circ Physiol 2016:ajpheart.00252.02015. PMID: 26945075. Full Text

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Al Feghali KA, and Elshaikh MA. Why brachytherapy boost is the treatment of choice for most women with locally advanced cervical carcinoma? Brachytherapy 2016;PMID: 26810408. Full Text

Al Feghali KA, Robbins JR, Mahan M, Burmeister C, Khan NT, Rasool N, Munkarah A, and Elshaikh MA. Predictive capacity of 3 comorbidity indices in estimating survival endpoints in women with early-stage endometrial carcinoma Int J Gynecol Cancer 2016;PMID: 27488218. Full Text

Beitler JJ, Quon H, Jones CU, Salama JK, Busse PM, Cooper JS, Koyfman SA, Ridge JA, Saba NF, Siddiqui F, Smith RV, Worden F, Yao M, and Yom SS. ACR Appropriateness Criteria(R) Locoregional therapy for resectable oropharyngeal squamous cell carcinomas Head Neck 2016;PMID: 27330003. Full Text

Berman AT, Rosenthal SA, Moghanaki D, Woodhouse KD, Movsas B, and Vapiwala N. Focusing on the "person" in personalized medicine: The future of patient-centered care in radiation oncology J Am Coll Radiol 2016; 13(12 Pt B):1571-1578. PMID: 27888944. Full Text

Burmeister J, Chen Z, Chetty IJ, Dieterich S, Doemer A, Dominello MM, Howell RM, McDermott P, Nalichowski A, Prisciandaro J, Ritter T, Smith C, Schreiber E, Shafman T, Sutlief S, and Xiao Y. The american society for radiation oncology's 2015 core physics curriculum for radiation oncology residents Int J Radiat Oncol Biol Phys 2016; 95(4):1298-1303. PMID: 27354135. Full Text

Chen RC, Hoffman KE, Sher DJ, Showalter TN, Morrell R, Chen AB, Benda R, Nguyen PL, Movsas B, and Hardenbergh P. Development of a standard survivorship care plan template for radiation oncologists Pract Radiat Oncol 2016; 6(1):57-65. PMID: 26778795. Article Request Form

Chetvertkov MA, Siddiqui F, Kim J, Chetty I, Kumarasiri A, Liu C, and Gordon JJ. Use of regularized principal component analysis to model anatomical changes during head and neck radiation therapy for treatment adaptation and response assessment Med Phys 2016; 43(10):5307. PMID: 27782712. Article request form

Davis BJ, Taira AV, Nguyen PL, Assimos DG, D'Amico AV, Gottschalk AR, Gustafson GS, Keole SR, Liauw SL, Lloyd S, McLaughlin PW, Movsas B, Prestidge BR, Showalter TN, and Vapiwala N. ACR appropriateness criteria permanent source brachytherapy for prostate cancer Brachytherapy 2016;PMID: 27964905. Full text

Elmghirbi R, Nagaraja TN, Brown SL, Panda S, Aryal MP, Keenan KA, Bagher-Ebadian H, Cabral G, and Ewing JR. Acute temporal changes of mri-tracked tumor vascular parameters after combined anti-angiogenic and radiation treatments in a rat glioma model: Identifying signatures of synergism Radiat Res 2016;PMID: 28001908. Full text

Elshaikh MA, Vance S, Gaffney DK, Biagioli M, Jhingran A, Jolly S, Kidd E, Lee LJ, Li L, Moore DH, Rao GG, Wahl AO, Williams NL, Yashar CM, and Small W, Jr. ACR appropriateness criteria management of recurrent endometrial cancer Am J Clin Oncol 2016;PMID: 27400117. Full Text

Elshaikh MA. In reply to Binder et al "adult comorbidity evaluation 27 score in endometrial cancer patient" Am J Obstet Gynecol 2016;PMID: 27640945. Full Text

Feldman AM, Zhang Z, Buekers T, and Elshaikh MA. Management of gynaecologic plasmacytoma: A review article J Obstet Gynaecol 2016:1-6. PMID: 27760483. Article request form

Feng M, Moran JM, Benedetti L, Boike TP, Dryden D, Fraser C, Griffith KA, Gustafson GS, Haywood J, Jagsi R, Matuszak MM, Nurushev TS, Radawski JD, Speers C, Walker EM, Hayman JA, and Pierce LJ. Time trends and predictors of heart dose from breast radiation therapy in a large consortium of community and academic practices Int J Radiat Oncol Biol Phys 2016; 96(2s):E15-e16. PMID: 27673907. Full Text

Freytag SO, Zhang Y, and Siddiqui F. Preclinical toxicology of oncolytic adenovirus-mediated cytotoxic and interleukin-12 gene therapy for prostate cancer Mol Ther Oncolytics 2015; 2PMID: 26767191. Full Text

119

Gerber DE, Urbanic JJ, Langer C, Hu C, Chang IF, Lu B, Movsas B, Jeraj R, Curran WJ, and Bradley JD. Treatment design and rationale for a randomized trial of cisplatin and etoposide plus thoracic radiotherapy followed by nivolumab or placebo for locally advanced non-small-cell lung cancer (rtog 3505) Clin Lung Cancer 2016;PMID: 27923550. Full text

Gladstone DJ, Kry SF, Xiao Y, and Chetty IJ. Dose specification for NRG radiation therapy trials Int J Radiat Oncol Biol Phys 2016; 95(5):1344-1345. PMID: 27479721. Full Text

Gordon JJ. On the feasibility of extracting dose-response curves from clinical DVH data using correlation and regression analysis Biomedical Physics and Engineering Express 2016; 2(1)PMID: Article Request Form

Guttmann DM, Li H, Sevak P, Grover S, Jacobson G, Feldman A, Rubin S, Chu C, Bhatia S, Elshaikh MA, and Lin LL. The impact of adjuvant therapy on survival and recurrence patterns in women with early-stage uterine carcinosarcoma: A multi-institutional study Int J Gynecol Cancer 2016; 26(1):141-148. PMID: 26509850. Full Text

Isrow D, Burmeister C, Hanna RK, and Elshaikh MA. Survival endpoints for young women with early stage uterine endometrioid carcinoma: a matched analysis Eur J Obstet Gynecol Reprod Biol 2016; 207:115-120. PMID: 27838535. Full Text

Karam I, Yao M, Heron DE, Poon I, Koyfman SA, Yom SS, Siddiqui F, Lartigau E, Cengiz M, Yamazaki H, Hara W, Phan J, Vargo JA, Lee V, Foote RL, Harter KW, Lee NY, Sahgal A, and Lo SS. Survey of current practices from the international stereotactic body radiotherapy consortium (isbrtc) for head and neck cancers Future Oncol 2016;PMID: 27842456. Article Request Form

Kim J, Wu Q, Zhao B, Wen N, Ajlouni M, Movsas B, and Chetty IJ. To gate or not to gate - dosimetric evaluation comparing Gated vs. ITV-based methodologies in stereotactic ablative body radiotherapy (SABR) treatment of lung cancer Radiat Oncol 2016; 11(1):125. PMID: 27659780. Full Text

Kim JH, Brown SL, and Kolozsvary A. Methods to mitigate injury from radiation exposure by administering cxcr4 antagonist during decisive treatment window Google Patents 2016;PMID: Not assigned. Full Text

Koyfman SA, Cooper JS, Beitler JJ, Busse PM, Jones CU, McDonald MW, Quon H, Ridge JA, Saba NF, Salama JK, Siddiqui F, Smith RV, Worden F, Yao M, and Yom SS. Acr appropriateness criteria((r)) aggressive nonmelanomatous skin cancer of the head and neck Head Neck 2016; 38(2):175-182. PMID: 26791005. Article Request Form

Liu LJ, Brown SL, Ewing JR, Ala BD, Schneider KM, and Schlesinger M. Estimation of tumor interstitial fluid pressure (tifp) noninvasively PLoS One 2016; 11(7):e0140892. PMID: 27467886. Full Text

Mahmoud OM, Gabel M, Gibbon D, Leiser A, Isani S, Cracchiolo B, Khan AJ, and Elshaikh MA. Can chemotherapy boost the survival benefit of adjuvant radiation therapy in early-stage cervical cancer with intermediate risk factors: A population-based study Int J Radiat Oncol Biol Phys 2016; 96(2s):E287. PMID: 27674277. Full Text

Mahmoud O, Hathout L, Shaaban SG, Elshaikh MA, Beriwal S, and Small W, Jr. Can chemotherapy boost the survival benefit of adjuvant radiotherapy in early stage cervical cancer with intermediate risk factors? A population based study Gynecol Oncol 2016;PMID: 27769525. Full Text

Meyer JE, Dilling TJ, Amdur RJ, Strasser JF, Tendulkar R, Lee WR, Jani AB, Elshaikh M, Poppe MM, Takita C, Currey A, Cheng SK, Jagsi R, Kuo JV, Chen AM, Dragun AE, Bradley K, Beriwal S, Smith RP, Chen RC, Rosenzweig K, Kim S, and Mehta K. In regard to Wu and Vapiwala et al Int J Radiat Oncol Biol Phys 2016; 94(4):858-859. PMID: 26972659. Full Text

Modh A, Ghanem AI, Burmeister C, Rasool N, and Elshaikh MA. Trends in the utilization of adjuvant vaginal brachytherapy in women with early-stage endometrial carcinoma: Results of an

120 updated period analysis of SEER data Brachytherapy 2016;PMID: 27475480. Full Text

Movsas TZ, Yechieli R, Movsas B, and Darwish-Yassine M. Partner's perspective on long-term sexual dysfunction after prostate cancer treatment Am J Clin Oncol 2016; 39(3):276-279. PMID: 24685887. Full Text

Nazem-Zadeh MR, Bowyer SM, Moran JE, Davoodi-Bojd E, Zillgitt A, Weiland BJ, Bagher- Ebadian H, Mahmoudi F, Elisevich K, and Soltanian-Zadeh H. MEG Coherence and DTI Connectivity in mTLE Brain Topogr 2016;PMID: 27060092. Full Text

Pauszek RF, 3rd, Kodali G, Siddiqui MS, and Stanley RJ. Overlapping electronic states with nearly parallel transition dipole moments in reduced anionic flavin can distort photobiological dynamics J Am Chem Soc 2016; 138(45):14880- 14889. PMID: 27686753. Article Request Form

Price RG, Kim JP, Zheng W, Chetty IJ, and Glide-Hurst C. Image guided radiation therapy using synthetic computed tomography images in brain cancer Int J Radiat Oncol Biol Phys 2016;PMID: 27209500. Full Text

Qin Y, Zhong H, Wen N, Snyder K, Huang Y, and Chetty IJ. Deriving detector-specific correction factors for rectangular small fields using a scintillator detector J Appl Clin Med Phys 2016; 17(6):6433. PMID: 27929510. Article Request Form

Rodin D, Longo J, Sherertz T, Shah MM, Balagun O, Wendling N, Van Dyk J, Coleman CN, Xu MJ, and Grover S. Mobilising expertise and resources to close the radiotherapy gap in cancer care Clin Oncol (R Coll Radiol) 2017; 29(2):135-140. PMID: 27955997. Full text

Ross Green W, Hathout L, Khan AJ, Elshaikh MA, Beriwal S, Small W, Jr., and Mahmoud O. Revisiting Milan cervical cancer study: Do the original findings hold in the era of chemotherapy? Gynecol Oncol 2016;PMID: 27899201. Full Text

Saba NF, Salama JK, Beitler JJ, Busse PM, Cooper JS, Jones CU, Koyfman S, Quon H, Ridge JA, Siddiqui F, Worden F, Yao M, and Yom SS. ACR Appropriateness criteria(R) for nasopharyngeal carcinoma Head Neck 2016;PMID: 27131050. Full Text

Santoso AP, Song KH, Qin Y, Gardner SJ, Liu C, Chetty IJ, Movsas B, Ajlouni M, and Wen N. Evaluation of gantry speed on image quality and imaging dose for 4D cone-beam CT acquisition Radiat Oncol 2016; 11(1):98. PMID: 27473367. Full Text

Siddiqui F, Bentley GA, McLean SA, and Ryu S. Inflammatory pseudotumor of the pharynx: A rare entity Indian J Cancer 2015; 52(4):668-669. PMID: 26960513. Full Text

Siddiqui F, Smith RV, Yom SS, Beitler JJ, Busse PM, Cooper JS, Hanna EY, Jones CU, Koyfman SA, Quon H, Ridge JA, Saba NF, Worden F, Yao M, and Salama JK. ACR appropriateness criteria(R) nasal cavity and paranasal sinus cancers Head Neck 2016;PMID: 28032679. Full text

Siebers JV, and Gordon JJ. Regarding: "The dosimetric impact of image guided radiation therapy by intratumoral fiducial markers" Pract Radiat Oncol 2016;PMID: 27665054. Article Request Form

Small W, Jr., James JL, Moore TD, Fintel DJ, Lutz ST, Movsas B, Suntharalingam M, Garces YI, Ivker R, Moulder J, Pugh S, and Berk LB. Utility of the ace inhibitor captopril in mitigating radiation- associated pulmonary toxicity in lung cancer: Results from nrg oncology rtog 0123 Am J Clin Oncol 2016;PMID: 27100959. Full Text

Small W, Jr., Hayes JP, Suh WW, Abdel-Wahab M, Abrams RA, Azad N, Das P, Dragovic J, Goodman KA, Jabbour SK, Jones WE, 3rd, Konski AA, Koong AC, Kumar R, Lee P, Pawlik TM, and Herman JM. Acr appropriateness criteria(r) borderline and unresectable pancreas cancer Oncology (Williston Park) 2016; 30(7):619-624, 627, 632. PMID: 27422109. Full Text

Snyder KC, Kim J, Reding A, Fraser C, Gordon J, Ajlouni M, Movsas B, and Chetty IJ. Development and evaluation of a clinical model for lung cancer patients using stereotactic body

121 radiotherapy (SBRT) within a knowledge-based algorithm for treatment planning J Appl Clin Med Phys 2016; 17(6):6429. PMID: 27929499. Article Request Form

To DT, Kim JP, Price RG, Chetty IJ, and Glide-Hurst CK. Impact of incorporating visual biofeedback in 4D MRI J Appl Clin Med Phys 2016; 17(3):6017. PMID: 27167270. Article Request Form

Vance S, Burmeister C, Rasool N, Buekers T, and Elshaikh MA. Salvage versus adjuvant radiation treatment for women with early-stage endometrial carcinoma: A matched analysis Int J Gynecol Cancer 2016; 26(2):307-312. PMID: 26745700. Full Text

Wahl AO, Gaffney DK, Jhingran A, Yashar CM, Biagioli M, Elshaikh MA, Jolly S, Kidd E, Lee LJ, Li L, Moore DH, Rao GG, Williams NL, and Small W, Jr. Acr appropriateness criteria(r) adjuvant management of early-stage endometrial cancer Oncology (Williston Park) 2016; 30(9)PMID: 27633412. Full Text

Wen N, Snyder KC, Scheib SG, Schmelzer P, Qin Y, Li H, Siddiqui MS, and Chetty IJ. Technical Note: Evaluation of the systematic accuracy of a frameless, multiple image modality guided, linear accelerator based stereotactic radiosurgery system Med Phys 2016; 43(5):2527. PMID: 27147363. Full Text

Wen N, Lu S, Kim J, Qin Y, Huang Y, Zhao B, Liu C, and Chetty IJ. Precise film dosimetry for stereotactic radiosurgery and stereotactic body radiotherapy quality assurance using Gafchromic EBT3 films Radiat Oncol 2016; 11(1):132. PMID: 27716323. Full Text

Wu Q, Snyder KC, Liu C, Huang Y, Zhao B, Chetty IJ, and Wen N. Optimization of treatment geometry to reduce normal brain dose in radiosurgery of multiple brain metastases with single- isocenter volumetric modulated arc therapy Sci Rep 2016; 6:34511. PMID: 27688047. Full Text

Xu H, Vile DJ, Sharma M, Gordon JJ, and Siebers JV. Erratum: "Coverage-based treatment planning to accommodate deformable organ variations in prostate cancer treatment" [Med. Phys. 41(10), 101705 (14pp.) (2014)] Med Phys 2016; 43(6):3206. PMID: 27277064. Full Text

Xu H, Brown S, Chetty IJ, and Wen N. A systematic analysis of errors in target localization and treatment delivery for stereotactic radiosurgery using 2D/3D image registration Technol Cancer Res Treat 2016;PMID: 27582369. Full Text

Xu Y, Burmeister C, Hanna RK, Munkarah A, and Elshaikh MA. Predictors of survival after recurrence in women with early-stage endometrial carcinoma Int J Gynecol Cancer 2016;PMID: 27206283. Full Text

Zhong H, Adams J, Glide-Hurst C, Zhang H, Li H, and Chetty IJ. Development of a deformable dosimetric phantom to verify dose accumulation algorithms for adaptive radiotherapy J Med Phys 2016; 41(2):106-114. PMID: 27217622. Full Text

Zhong H, and Chetty IJ. Caution must be exercised when performing deformable dose accumulation for tumors undergoing mass changes during fractionated radiation therapy Int J Radiat Oncol Biol Phys 2017; 97(1):182-183. PMID: 27979447. Full text

122 RESEARCH ADMINISTRATION

Image Analysis Program

Afzali M, Ghaffari A, Fatemizadeh E, and Soltanian-Zadeh H. Medical image registration using sparse coding of image patches Comput Biol Med 2016; 73:56-70. PMID: 27085311. Full Text

Chapman CH, Zhu T, Nazem-Zadeh M, Tao Y, Buchtel HA, Tsien CI, Lawrence TS, and Cao Y. Diffusion tensor imaging predicts cognitive function change following partial brain radiotherapy for low- grade and benign tumors Radiother Oncol 2016;PMID: 27418525. Full Text

Hosseini MP, Nazem-Zadeh MR, Pompili D, Jafari-Khouzani K, Elisevich K, and Soltanian-Zadeh H. Comparative performance evaluation of automated segmentation methods of hippocampus from magnetic resonance images of temporal lobe epilepsy patients Med Phys 2016; 43(1):538. PMID: 26745947. Article Request Form

Iraji A, Calhoun VD, Wiseman N, Davoodi-Bojd E, Avanaki MR, Haacke EM, and Kou Z. The connectivity domain: Analyzing resting state fMRI data using feature-based data-driven and model- based methods Neuroimage 2016;PMID: 27079528. Full Text

Kobeissy FH, Guingab-Cagmat JD, Zhang Z, Moghieb A, Glushakova OY, Mondello S, Boutte AM, Anagli J, Rubenstein R, Bahmad H, Wagner AK, Hayes RL, and Wang KK. Neuroproteomics and systems biology approach to identify temporal biomarker changes post experimental traumatic brain injury in rats Front Neurol 2016; 7:198. PMID: 27920753. Full text

MaBouDi H, Shimazaki H, Amari S, and Soltanian-Zadeh H. Representation of higher-order statistical structures in natural scenes via spatial phase distributions Vision Res 2016; 120:61-73. PMID: 26278166. Article Request Form

Maleki-Balajoo S, Hossein-Zadeh GA, Soltanian-Zadeh H, and Ekhtiari H. Locally estimated hemodynamic response function and activation detection sensitivity in heroin-cue reactivity study Basic Clin Neurosci 2016; 7(4):299-314. PMID: 27872691. Full Text

Nazem-Zadeh MR, Bowyer SM, Moran JE, Davoodi-Bojd E, Zillgitt A, Weiland BJ, Bagher- Ebadian H, Mahmoudi F, Elisevich K, and Soltanian-Zadeh H. MEG Coherence and DTI Connectivity in mTLE Brain Topogr 2016;PMID: 27060092. Full Text

Nazem-Zadeh MR, Elisevich K, Air EL, Schwalb JM, Divine G, Kaur M, Wasade VS, Mahmoudi F, Shokri S, Bagher-Ebadian H, and Soltanian-Zadeh H. DTI-based response-driven modeling of mTLE laterality Neuroimage Clin 2016; 11:694-706. PMID: 27330966. Full Text

Rezaeian MR, Hossein-Zadeh GA, and Soltanian-Zadeh H. Simultaneous optimization of power and duration of radio-frequency pulse in PARACEST MRI Magn Reson Imaging 2016;PMID: 26956610. Full Text

Samadi S, Soltanian-Zadeh H, and Jutten C. Integrated Analysis of EEG and fMRI using sparsity of spatial maps Brain Topogr 2016;PMID: 27460558. Full Text

Wasade VS, Balki I, Bowyer SM, Gaddam S, Mohammadi-Nejad AR, Nazem-Zadeh MR, Soltanian-Zadeh H, Zillgitt A, and Spanaki-Varelas M. Controllable yawning expressed as focal seizures of frontal lobe epilepsy Epilepsy Behav Case Rep 2016; 6:61-63. PMID: 27668178. Full Text

123 Genetics Research

Brigolin C, McKenty N, Pindolia K, and Wolf B. Differential gene expression during early development in brains of wildtype and biotinidase-deficient mice Mol Genet Metab Rep 2016; 9:35-41. PMID: 27752475. Full Text

Procter M, Wolf B, and Mao R. Forty-eight novel mutations causing biotinidase deficiency Mol Genet Metab 2016;PMID: 26810761. Article Request Form

Wolf B. First microdeletion involving only the biotinidase gene that can cause biotinidase deficiency: A lesson for clinical practice Mol Genet Metab Rep 2016; 6:74-76. PMID: 27014582.

Wolf B. Successful outcomes of older adolescents and adults with profound biotinidase deficiency identified by newborn screening Genet Med 2016;PMID: 27657684. Article Request Form

124 SURGERY

Ali R, Schwalb JM, Nerenz DR, Antoine HJ, and Rubinfeld I. Use of the modified frailty index to predict 30-day morbidity and mortality from spine surgery J Neurosurg Spine 2016:1-5. PMID: 27153143. Full Text

Azuh O, Gammon H, Burmeister C, Frega D, Nerenz D, DiGiovine B, and Siddiqui A. Benefits of early active mobility in the medical intensive care unit - a pilot study Am J Med 2016;PMID: 27107920. Full Text

Baker-Genaw K, Kokas MS, Ahsan SF, Darnley-Fisch D, Drake S, Goyal N, Inamdar K, Moutzouros V, Prabhakar D, Rolland L, Sangha R, Shreve M, and Woodward A. Mapping direct observations from objective structured clinical examinations to the milestones across specialties J Grad Med Educ 2016; 8(3):429-434. PMID: 27413450. Full Text

Berian JR, Mohanty S, Ko CY, Rosenthal RA, and Robinson TN. Association of loss of independence with readmission and death after discharge in older patients after surgical procedures JAMA Surg 2016;PMID: 27409710. Full Text

Bisleri G, Tononi L, Morgan JA, Bordonali T, Cheema FH, Siddiqui OT, Repossini A, Rosati F, and Muneretto C. Separation of mediastinal shed blood during aortic valve surgery elicits a reduced inflammatory response J Cardiovasc Med (Hagerstown) 2016; 17(1):62-68. PMID: 24933196. Full Text

Bunnapradist S, Rostaing L, Alloway RR, West-Thielke P, Denny J, Mulgaonkar S, and Budde K. LCPT Once-Daily Extended-Release Tacrolimus Tablets Vs. Twice-Daily Capsules: A Pooled Analysis of Two Phase 3 Trials in Important De Novo and Stable Kidney Transplant Recipient Subgroups Transpl Int 2016;PMID: 26953629. Full Text

D'Agostino RS, Jacobs JP, Badhwar V, Paone G, Rankin JS, Han JM, McDonald D, Edwards FH, and Shahian DM. The society of thoracic surgeons adult cardiac surgery database: 2017 update on outcomes and quality Ann Thorac Surg 2016;PMID: 27884412. Full Text

Deeb D, Gao X, Liu Y, Zhang Y, Shaw J, Valeriote FA, and Gautam SC. The inhibition of cell proliferation and induction of apoptosis in pancreatic ductal adenocarcinoma cells by verrucarin A, a macrocyclic trichothecene, is associated with the inhibition of Akt/NF-small ka, CyrillicB/mTOR prosurvival signaling Int J Oncol 2016; 49(3):1139- 1147. PMID: 27573873. Article Request Form

Fontana RJ, Brown RS, Moreno-Zamora A, Prieto M, Joshi S, Londono MC, Herzer K, Chacko KR, Stauber RE, Knop V, Jafri SM, Castells L, Ferenci P, Torti C, Durand CM, Loiacono L, Lionetti R, Bahirwani R, Weiland O, Mubarak A, ElSharkawy AM, Stadler B, Montalbano M, Berg C, Pellicelli AM, Stenmark S, Vekeman F, Ionescu-Ittu R, Emond B, and Reddy KR. Daclatasvir combined with sofosbuvir or simeprevir in liver transplant recipients with severe recurrent hepatitis C infection Liver Transpl 2016;PMID: 26890629. Article Request Form

Gammon HM, Shelton CB, Siegert C, Dawson C, Sexton E, Burmeister C, Gnam G, and Siddiqui A. Self-turning for pressure injury prevention Wound Medicine 2016; 12:15-18. PMID: Not assigned Article Request Form

Gardner AK, Nepomnayshy D, Reickert C, Gee DW, Brydges R, Korndorffer JR, Jr., Scott DJ, and Sachdeva AK. The value proposition of simulation Surgery 2016;PMID: 27206331. Full Text

Go P, and Hammoud Z. Eventration of the diaphragm presenting as spontaneous pneumothorax Cleve Clin J Med 2016; 83(1):19-20. PMID: 26760517. Full Text

Go PH, Nemeh HW, Borgi J, Paone G, and Morgan JA. Effect of body mass index on outcomes in left ventricular assist device recipients J Card Surg 2016;PMID: 26856974. Full Text

Go PH, and Alvelo-Rivera M. An unusual manifestation of diabetic ketoacidosis Neth J Med 2016; 74(3):138. PMID: 27020997. Full Text

125 Goldberg JB, Shann KG, Fitzgerald D, Fuller J, Paugh TA, Dickinson TA, Paone G, Prager RL, and Likosky DS. The relationship between intra-operative transfusions and nadir hematocrit on post- operative outcomes after cardiac surgery J Extra Corpor Technol 2016; 48(4):188-193. PMID: 27994259. Article Request Form

Goodwin M, Ito K, Gupta AH, and Rivers EP. Protocolized care for early shock resuscitation Curr Opin Crit Care 2016; 22(5):416-423. PMID: 27583584. Full Text

Goyal N, Taylor AR, and Rivers EP. Relationship between central and peripheral venous oxygen saturation and lactate levels: A prospective study J Emerg Med 2016;PMID: 27210904. Full Text

Greenbaum AB, Babaliaros VC, Chen MY, Stine AM, Rogers T, O'Neill WW, Paone G, Thourani VH, Muhammad KI, Leonardi RA, Ramee S, Troendle JF, and Lederman RJ. Transcaval access and closure for transcatheter aortic valve replacement: A prospective investigation J Am Coll Cardiol 2016;PMID: 27989885. Full text

Gunn T, Paone G, Emery RW, and Ferraris VA. The case for a conservative approach to blood transfusion management in cardiac surgery Innovations (Phila) 2016; 11(3):157-164. PMID: 27532302. Full Text

Hammoud Z. The 5 most important recent publications regarding robotic esophageal surgery Semin Thorac Cardiovasc Surg 2016; 28(1):147-150. PMID: 27568152. Full Text

Healy MA, McCahill LE, Chung M, Berri R, Ito H, Obi SH, Wong SL, Hendren S, and Kwon D. Intraoperative fluid resuscitation strategies in pancreatectomy: Results from 38 hospitals in michigan Ann Surg Oncol 2016;PMID: 27116681. Full Text

Hencken L, To L, Ly N, and Morgan JA. Serotonin syndrome following methylene blue administration for vasoplegic syndrome J Card Surg 2016; 31(4):208-210. PMID: 26934199. Full Text

Henke PK, Park YJ, Hans S, Bove P, Cuff R, Kazmers A, Schreiber T, Gurm HS, and Grossman PM. The association of peri-procedural blood transfusion with morbidity and mortality in patients undergoing percutaneous lower extremity vascular interventions: Insights from BMC2 VIC PLoS One 2016; 11(11):e0165796. PMID: 27835656. Full Text

Jacobs JP, Shahian DM, Prager RL, Edwards FH, McDonald D, Han JM, D'Agostino RS, Jacobs ML, Kozower BD, Badhwar V, Thourani VH, Gaissert HA, Fernandez FG, Wright C, Fann JI, Paone G, Sanchez JA, Cleveland JC, Jr., Brennan JM, Dokholyan RS, O'Brien SM, Peterson ED, Grover FL, and Patterson GA. Introduction to the sts national database series: Outcomes analysis, quality improvement, and patient safety Ann Thorac Surg 2015; 100(6):1992- 2000. PMID: 26525868. Full Text

Jacobs JP, Shahian DM, Prager RL, Edwards FH, McDonald D, Han JM, D'Agostino RS, Jacobs ML, Kozower BD, Badhwar V, Thourani VH, Gaissert HA, Fernandez FG, Wright CD, Paone G, Cleveland JC, Jr., Brennan JM, Dokholyan RS, Brothers L, Vemulapalli S, Habib RH, O'Brien SM, Peterson ED, Grover FL, Patterson GA, and Bavaria JE. The society of thoracic surgeons national database 2016 annual report Ann Thorac Surg 2016; 102(6):1790-1797. PMID: 27847042. Full Text

Jesse MT, Rubinstein E, Eshelman A, Wee C, Tankasala M, Li J, and Abouljoud M. Lifestyle and self- management by those who live it: Patients engaging patients in a chronic disease model Perm J 2016; 20(3)PMID: 27455056. Article Request Form

Jiagge E, Jibril AS, Chitale D, Bensenhaver JM, Awuah B, Hoenerhoff M, Adjei E, Bekele M, Abebe E, Nathanson SD, Gyan K, Salem B, Oppong J, Aitpillah F, Kyei I, Bonsu EO, Proctor E, Merajver SD, Wicha M, Stark A, and Newman LA. Comparative analysis of breast cancer phenotypes in african american, white american, and west versus east african patients: Correlation between african ancestry and triple-negative breast cancer Ann Surg Oncol 2016;PMID: 27469125. Full Text

Kabbani LS, Wasilenko S, Nypaver TJ, Weaver MR, Taylor AR, Abdul-Nour K, Borgi J, and Shepard AD. Socioeconomic disparities affect survival after aortic dissection J Vasc Surg 2016; 64(5):1239-1245. PMID: 27374067. Full Text 126 Kabbani L, Munie S, Lin J, Velez M, Isseh I, Brooks S, Leix S, and Shepard A. Flow patterns in the carotid arteries of patients with left ventricular assist devices Ann Vasc Surg 2016;PMID: 27531092. Full Text

Kabbani L, Balraj P, Mathews J, Tinney F, Jr., Schwartz S, Kwon D, Braun F, and Wasilenko S. Epithelioid hemangioendothelioma presenting as inferior vena cava obstruction diagnosed using an endovascular thrombectomy device Ann Vasc Surg 2016;PMID: 28012782. Full text

Kakkos SK, Kouri AK, Tsolakis IA, Haddad GK, Lampropoulos GC, and Karnabatidis D. Surgical and endovascular revision of brachio-basilic vein fistula J Vasc Access 2016; 17 Suppl 1:6-11. PMID: 26951896. Article Request Form

Karamanos E, Van Esbroeck A, Mohanty S, Syed Z, and Rubinfeld I. Quality and outcomes reporting in trauma using international statistical classification for diseases, ninth revision codes J Surg Res 2015; 199(2):529-535. PMID: 26119273. Full Text

Karamanos E, Dulchavsky S, Beale E, Inaba K, and Demetriades D. Diabetes mellitus in patients presenting with adhesive small bowel obstruction: Delaying surgical intervention results in worse outcomes World J Surg 2016; 40(4):863-869. PMID: 26566780. Full Text

Karamanos E, Schmoekel N, Blyden D, Falvo A, and Rubinfeld I. Association of unplanned reintubation with higher mortality in old, frail patients: A national surgical quality-improvement program analysis Perm J 2016; 20(4)PMID: 27768568. Article request form

Karamanos E, Kandagatla P, Watson J, Schmoekel N, and Siddiqui A. Development and validation of a scoring system to predict surgical site infection after ventral hernia repair: A michigan surgical quality collaborative study World J Surg 2016;PMID: 27872976. Full Text

Kolbe N, Sisson K, and Albaran R. Abdominal pain and hematuria: duodenal perforation from ingested foreign body causing ureteral obstruction and hydronephrosis J Surg Case Rep 2016; 2016(2)PMID: 26903557. Full Text

Krasnick BA, Nathanson SD, Arbabi CN, Chitale DA, and Peterson EL. The predictive value of increased sentinel lymph node volume in breast cancer Surg Oncol 2016; 25(3):321-325. PMID: 27566039. Full Text

Likosky DS, Zhang M, Paone G, Collins J, DeLucia A, 3rd, Schreiber T, Theurer P, Kazziha S, Leffler D, Wunderly DJ, Gurm HS, and Prager RL. Impact of institutional culture on rates of transfusions during cardiovascular procedures: The Michigan experience Am Heart J 2016; 174:1-6. PMID: 26995363. Full Text

Likosky DS, Paugh TA, Harrington SD, Wu X, Rogers MA, Dickinson TA, DeLucia A, 3rd, Benedetti BR, Prager RL, Zhang M, and Paone G. Prediction of transfusions after isolated coronary artery bypass grafting surgical procedures Ann Thorac Surg 2016;PMID: 27726856. Full Text

Lin JC, Kabbani LS, Peterson EL, Masabni K, Morgan JA, Brooks S, Wertella KP, and Paone G. Clinical utility of carotid duplex ultrasound prior to cardiac surgery J Vasc Surg 2016; 63(3):710-714. PMID: 26916583. Full Text

Lin JC, and Myers E. Three-dimensional printing for preoperative planning of renal artery aneurysm surgery J Vasc Surg 2016; 64(3):810. PMID: 27565599. Full Text

Liu Y, Gao X, Deeb D, Zhang Y, Shaw J, Valeriote FA, and Gautam SC. Mycotoxin verrucarin A inhibits proliferation and induces apoptosis in prostate cancer cells by inhibiting prosurvival Akt/NF- kB/mTOR signaling J Exp Ther Oncol 2016; 11(4):251-260. PMID: 27849335. Article Request Form

Louwers L, Schnickel G, and Rubinfeld I. Use of a simplified frailty index to predict clavien 4 complications and mortality after hepatectomy: Analysis of the national surgical quality improvement project database Am J Surg 2015;PMID: 26800866. Full Text

127 Macedo M, Kim B, Khoury R, and Narkiewicz L. A rare case of right lower quadrant abdominal pain Am J Emerg Med 2016;PMID: 27842925. Full Text

Miller-Matero LR, Bryce K, Hyde-Nolan ME, Dykhuis KE, Eshelman A, and Abouljoud M. Health literacy status affects outcomes for patients referred for transplant Psychosomatics 2016;PMID: 27231187. Full Text

Mohammad F, Kabbani L, Lin J, Karamanos E, Esmael F, and Shepard A. Post- procedural pseudoaneurysms: Single-center experience Vascular 2016;PMID: 27370682. Full Text

Mohanty S, Rosenthal RA, Russell MM, Neuman MD, Ko CY, and Esnaola NF. Optimal perioperative management of the geriatric patient: A best practices guideline from the american college of surgeons NSQIP and the american geriatrics society J Am Coll Surg 2016;PMID: 27049783. Full Text

Monaghan KG, Gonzalez HC, Levin AM, Abouljoud MS, and Gordon SC. Post-transplant course of hepatitis C after living donor liver transplantation in association with polymorphisms near IFNL3 J Interferon Cytokine Res 2015; 35(4):313-316. PMID: 25343304. Article Request Form

Morgan JA, and O'Neill WW. Percutaneous right ventricular assist device support in a patient supported by an LVAD Asaio j 2016;PMID: 26771398. Full Text

Morgan JA, Go PH, Xuereb L, Kaur B, Akrawe S, Nemeh HW, Borgi J, Lanfear DE, Williams CT, and Paone G. Outcomes on continuous flow left ventricular assist devices: A single institutional 9-year experience Ann Thorac Surg 2016;PMID: 27173072. Full Text

Nagai S, Mangus RS, Anderson E, Ekser B, Kubal CA, Fridell JA, and Tector AJ. Intestinal graft failure: Should we perform the allograft enterectomy before or with retransplantation? Transplantation 2016;PMID: 26901076. Full Text

Nash NA, Okoye O, Albuz O, Vogt KN, Karamanos E, Inaba K, and Demetriades D. Seat belt use and its effect on abdominal trauma: A national trauma databank study Am Surg 2016; 82(2):134-139. PMID: 26874135. Full Text

Neugut AI, Hillyer GC, Kushi LH, Lamerato L, Buono DL, Nathanson SD, Bovbjerg DH, Mandelblatt JS, Tsai WY, Jacobson JS, and Hershman DL. A prospective cohort study of early discontinuation of adjuvant chemotherapy in women with breast cancer: the breast cancer quality of care study (BQUAL) Breast Cancer Res Treat 2016;PMID: 27287779. Full Text

Newman LA. Parsing the etiology of breast cancer disparities J Clin Oncol 2016;PMID: 26786919. Full Text

Newman LA, Stark A, Chitale D, Pepe M, Longton G, Worsham MJ, Nathanson SD, Miller P, Bensenhaver JM, Proctor E, Swain M, Patriotis C, and Engstrom PF. Association between benign breast disease in african american and white american women and subsequent triple-negative breast cancer JAMA Oncol 2016;PMID: 28006062. Full text

Nguyen HB, Jaehne AK, Jayaprakash N, Semler MW, Hegab S, Yataco AC, Tatem G, Salem D, Moore S, Boka K, Gill JK, Gardner-Gray J, Pflaum J, Domecq JP, Hurst G, Belsky JB, Fowkes R, Elkin RB, Simpson SQ, Falk JL, Singer DJ, and Rivers EP. Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE Crit Care 2016; 20(1):160. PMID: 27364620. Full Text

Pahari H, Chaudhary RJ, Thiagarajan S, Raut V, Babu R, Bhangui P, Goja S, Rastogi A, Vohra V, and Soin AS. Hepatic venous and inferior vena cava morphology no longer a barrier to living donor liver transplantation for budd- chiari syndrome: Surgical techniques and outcomes Transplant Proc 2016; 48(8):2732-2737. PMID: 27788809. Full Text

Parekh R, Kazimi M, Skorupski S, Fagoaga O, Jafri S, and Segovia MC. Intestine transplantation across a positive crossmatch with preformed donor-specific antibodies Transplant Proc 2016; 48(2):489-491. PMID: 27109984. Full Text

128 Park KU, Rubinfeld I, Hodari A, and Hammoud Z. Prolonged length of stay after esophageal resection: Identifying drivers of increased length of stay using the nsqip database J Am Coll Surg 2016;PMID: 27118713. Full Text

Patel HJ, Herbert MA, Paone G, Heiser JC, Shannon FL, Theurer PF, Bell GF, and Prager RL. The midterm impact of transcatheter aortic valve replacement on surgical aortic valve replacement in michigan Ann Thorac Surg 2016;PMID: 27154157. Full Text

Paulson D, Shah M, Miller-Matero LR, Eshelman A, and Abouljoud M. Cognition predicts quality of life among patients with end-stage liver disease Psychosomatics 2016;PMID: 27184728. Full Text

Petersen L, Carlson K, Kopkash K, Witt T, and Madrigrano A. Preoperative antibiotics do not reduce postoperative infections following needle-localized lumpectomy Breast J 2016;PMID: 27615388. Full Text

Qazi Y, Shaffer D, Kaplan B, Kim D, Luan FL, Peddi VR, Shihab F, Tomlanovich S, Yilmaz S, McCague K, Patel D, and Mulgaonkar S. Efficacy and safety of everolimus plus low-dose tacrolimus versus mycophenolate mofetil plus standard-dose tacrolimus in de novo renal transplant recipients: 12-month data Am J Transplant 2016;PMID: 27775865. Full Text

Rao B, Jafri SM, Kazimi M, Mullins K, Raoufi M, and Segovia MC. A case report of acute cellular rejection following intestinal transplantation managed with adalimumab Transplant Proc 2016; 48(2):536-538. PMID: 27109995. Full Text

Rao B, Segovia MC, Kazimi M, Parekh R, Raoufi M, and Jafri SM. Use of everolimus after multivisceral transplantation: A report of two cases Transplant Proc 2016; 48(2):485-488. PMID: 27109983. Full Text

Ruggero JM, and Prakash SN. Symptomatic lymphoepithelial cyst of the pancreas: successful treatment without pancreatic resection J Surg Case Rep 2016; 2016(4)PMID: 27141046. Full Text

Safwan M, Nagai S, and Abouljoud MS. Portal vein inflow from enlarged coronary vein in liver transplantation: Surgical approach and technical tips: A case report Transplant Proc 2016; 48(9):3070-3072. PMID: 27932149. Full text

Scally CP, Varban OA, Carlin AM, Birkmeyer JD, and Dimick JB. Video ratings of surgical skill and late outcomes of bariatric surgery JAMA Surg 2016:e160428. PMID: 27074114. Full Text

Schmoekel NH, O'Connor JV, and Scalea TM. Nonoperative damage control: The use of extracorporeal membrane oxygenation in traumatic bronchial avulsion as a bridge to definitive operation Ann Thorac Surg 2016; 101(6):2384- 2386. PMID: 27211954. Full Text

Shan R, Szmydynger-Chodobska J, Warren OU, Mohammad F, Zink BJ, and Chodobski A. A new panel of blood biomarkers for the diagnosis of mild traumatic brain injury/concussion in adults J Neurotrauma 2016; 33(1):49-57. PMID: 25794137. Full Text

Simmons RM, Ballman KV, Cox C, Carp N, Sabol J, Hwang RF, Attai D, Sabel M, Nathanson D, Kenler A, Gold L, Kaufman C, Han L, Bleznak A, Stanley Smith J, Holmes D, Fornage B, Le-Petross C, Hoda S, McCall L, and Hunt KK. A phase II trial exploring the success of cryoablation therapy in the treatment of invasive breast carcinoma: Results from ACOSOG (Alliance) Z1072 Ann Surg Oncol 2016;PMID: 27221361. Full Text

Strobel RJ, Liang Q, Zhang M, Wu X, Rogers MA, Theurer PF, Fishstrom AB, Harrington SD, DeLucia A, 3rd, Paone G, Patel HJ, Prager RL, and Likosky DS. A preoperative risk model for postoperative pneumonia after coronary artery bypass grafting Ann Thorac Surg 2016;PMID: 27261082. Full Text

Tahir RA, Asmaro K, Pabaney A, Kole M, Nypaver T, and Marin H. Separate origins of the left internal and external carotid arteries from the aortic arch and cervical internal carotid artery aneurysm in a patient with Noonan syndrome J Neurointerv Surg 2016;PMID: 27466463. Full Text

129 Takahashi K, Obeid J, Burmeister CS, Bruno DA, Kazimi MM, Yoshida A, Abouljoud MS, and Schnickel GT. Intrahepatic cholangiocarcinoma in the liver explant after liver transplantation: Histological differentiation and prognosis Ann Transplant 2016; 21:208-215. PMID: 27068242. Article Request Form

Takahashi K, Patel AK, Putchakayala KG, Denny JE, Kim DY, and Malinzak LE. Arterioenteric fistula 12 years after kidney transplant Kidney Int 2016; 90(3):710. PMID: 27521122. Full Text

Takahashi K, Nagai S, Putchakayala KG, Safwan M, Li AY, Kane WJ, Singh PL, Collins KM, Rizzari MD, Yoshida A, Schnickel GT, and Abouljoud MS. Prognostic impact of postoperative low platelet count after liver transplantation Clin Transplant 2016;PMID: 27992667. Full text

Toursavadkohi S, Kakkos SK, Rubinfeld I, and Shepard A. Lower extremity microembolism in open vs. Endovascular abdominal aortic aneurysm repair Front Surg 2016; 3:18. PMID: 27066488. Full Text

Varban OA, Greenberg CC, Schram J, Ghaferi AA, Thumma JR, Carlin AM, and Dimick JB. Surgical skill in bariatric surgery: Does skill in one procedure predict outcomes for another? Surgery 2016; 160(5):1172-1181. PMID: 27324569. Full Text

Wang DD, Eng M, Greenbaum A, Myers E, Forbes M, Pantelic M, Song T, Nelson C, Divine G, Taylor A, Wyman J, Guerrero M, Lederman RJ, Paone G, and O'Neill W. Predicting LVOT Obstruction After TMVR JACC Cardiovasc Imaging 2016;PMID: 27209112. Full Text

Wang DD, Eng M, Kupsky D, Myers E, Forbes M, Rahman M, Zaidan M, Parikh S, Wyman J, Pantelic M, Song T, Nadig J, Karabon P, Greenbaum A, and O'Neill W. Application of 3- dimensional computed tomographic image guidance to WATCHMAN implantation and impact on early operator learning curve: Single-center experience JACC Cardiovasc Interv 2016; 9(22):2329-2340. PMID: 27884358. Full Text

Xuereb L, Go PH, Kaur B, Akrawe S, Borgi J, Paone G, and Morgan JA. Should patients with hepatic fibrosis undergo LVAD implantation: A comparative analysis Asaio j 2016;PMID: 27014788. Full Text

Xuereb L, Go PH, Kaur B, Akrawe S, Nemeh HW, Borgi J, Williams CT, Paone G, and Morgan JA. Impact of preoperative atrial fibrillation on postoperative thromboembolic events after left ventricular assist device implantation Ann Thorac Surg 2016; 102(5):1543-1549. PMID: 27469338. Full Text

Yip J, Bruno DA, Burmeister C, Kazimi M, Yoshida A, Abouljoud MS, and Schnickel GT. Deep vein thrombosis and pulmonary embolism in liver transplant patients: Risks and prevention Transplant Direct 2016; 2(4):e68. PMID: 27500259. Full Text

Plastic Surgery

Meier EM, Wu B, Siddiqui A, Tepper DG, Longaker MT, and Lam MT. Mechanical stimulation increases knee meniscus gene RNA-level expression in adipose-derived stromal cells Plast Reconstr Surg Glob Open 2016; 4(9):e864. PMID: 27757329. Full Text

Reddy V, and Coffey MJ. Plastic surgery and suicide: A clinical guide for plastic surgeons Plast Reconstr Surg Glob Open 2016; 4(8):e828. PMID: 27622096. Full Text

Reinard KA, Zakaria HM, Qatanani A, Lee IY, Rock JP, and Houin HP. Preoperative external tissue expansion for complex cranial reconstructions J Neurosurg 2016:1-8. PMID: 26722853. Full Text

130 UROLOGY

Abdollah F, Briganti A, Montorsi F, Stenzl A, Stief C, Tombal B, Van Poppel H, and Touijer K. Contemporary role of salvage lymphadenectomy in patients with recurrence following radical prostatectomy Eur Urol 2015; 67(5):839-849. PMID: 24698524. Full Text

Abdollah F, Sun M, Sammon JD, Choueiri TK, Menon M, Weissman JS, and Trinh QD. Prevalence of nonrecommended screening for prostate cancer and breast cancer in the United States: A nationwide survey analysis JAMA Oncol 2016;PMID: 26794060. Full Text

Abdollah F, Dalela D, Sood A, Sammon J, Jeong W, Beyer B, Fossati N, Rogers CG, Diaz-Insua M, Peabody J, Haese A, Montorsi F, Graefen M, Briganti A, and Menon M. Intermediate-term cancer control outcomes in prostate cancer patients treated with robotic-assisted laparoscopic radical prostatectomy: a multi-institutional analysis World J Urol 2016;PMID: 26873596. Full Text

Abdollah F, Klett DE, Sammon JD, Dalela D, Sood A, Hsu L, Diaz M, Gupta N, Peabody JO, Trinh QD, and Menon M. Predicting lymph node invasion in patients treated with robot-assisted radical prostatectomy Can J Urol 2016; 23(1):8141-8150. PMID: 26892054. Article Request Form

Abdollah F, Ye Z, Miller DC, Linsell SM, Montie JE, Peabody JO, and Ghani KR. Understanding the use of prostate biopsy among men with limited life expectancy in a statewide quality improvement collaborative Eur Urol 2016;PMID: 27113032. Full Text

Abdollah F, Moschini M, Sood A, Sammon J, Dalela D, Hsu L, Beyer B, Haese A, Graefen M, Gandaglia G, Montorsi F, Briganti A, and Menon M. When should a positive surgical margin ring a bell? An analysis of a multi- institutional robot-assisted laparoscopic radical prostatectomy database J Endourol 2016; 30(2):201-207. PMID: 26415003. Full Text

Abdullah N, Dalela D, Barod R, Larson J, Johnson M, Mass A, Zargar H, Allaf M, Bhayani S, Stifelman M, Kaouk J, and Rogers C. Robotic partial nephrectomy for renal tumours in obese patients: Perioperative outcomes in a multi-institutional analysis Can Urol Assoc J 2015; 9(11-12):E859-862. PMID: 26788235. Full Text

Abdullah N, Rahbar H, Barod R, Dalela D, Larson J, Johnson M, Mass A, Zargar H, Allaf M, Bhayani S, Stifelman M, Kaouk J, and Rogers C. Multicentre outcomes of robot-assisted partial nephrectomy after major open abdominal surgery BJU Int 2016; 118(2):298-301. PMID: 27417163. Full Text

Abdullah N, Rahbar H, Barod R, Dalela D, Larson J, Johnson M, Mass A, Zargar H, Kaouk J, Allaf M, Bhayani S, Stifelman M, and Rogers C. Use of the Satinsky clamp for hilar clamping during robotic partial nephrectomy: indications, technique, and multi-center outcomes J Robot Surg 2016;PMID: 27329237. Full Text

Bardia A, Sood A, Mahmood F, Orhurhu V, Mueller A, Montealegre-Gallegos M, Shnider MR, Ultee KH, Schermerhorn ML, and Matyal R. Combined epidural-general anesthesia vs general anesthesia alone for elective abdominal aortic aneurysm repair JAMA Surg 2016;PMID: 27603002. Full Text

Chao GF, Krishna N, Aizer AA, Dalela D, Hanske J, Li H, Meyer CP, Kim SP, Mahal BA, Reznor G, Schmid M, Choueiri TK, Nguyen PL, M OL, and Trinh QD. Asian Americans and prostate cancer: A nationwide population-based analysis Urol Oncol 2016; 34(5):233.e237-233.e215. PMID: 26725248. Full Text

Cole AP, Abdollah F, and Trinh QD. Observational studies to contextualize surgical trials Eur Urol 2016;PMID: 26992277. Full Text

Cole AP, Leow JJ, Chang SL, Chung BI, Meyer CP, Kibel AS, Menon M, Nguyen PL, Choueiri TK, Reznor G, Lipsitz SR, Sammon JD, Sun M, and Trinh QD. Surgeon and hospital-level variation in the costs of robot-assisted radical prostatectomy J Urol 2016;PMID: 27157376. Full Text

131 Cole AP, Trinh QD, Sood A, and Menon M. The rise of robotic surgery in the new millennium J Urol 2016;PMID: 28010986. Full text

Concodora CW, Maizels M, Dean GE, Weiss DA, Alpert SA, Edmondson JD, Elder JS, Herndon A, Elmore JM, and Rychlik K. Checklist assessment tool to evaluate suitability and success of neonatal clamp circumcision: A prospective study J Pediatr Urol 2016;PMID: 27363331. Full Text

Dabaja AA, and Goldstein M. When is a varicocele repair indicated: the dilemma of hypogonadism and erectile dysfunction? Asian J Androl 2016; 18(2):213-216. PMID: 26696437. Full Text

Dalela D, and Menon M. Contemporary trends in radical prostatectomy in the United States: Open vs minimally invasive surgery Mayo Clin Proc 2016; 91(1):1-2. PMID: 26763508. Full Text

Dalela D, and Abdollah F. The importance of frailty: Know thy patient BJU Int 2016; 117(5):716-717. PMID: 27079481. Full Text

Dalela D, Loppenberg B, Sood A, Sammon J, and Abdollah F. Contemporary role of the decipher(r) test in prostate cancer management: Current practice and future perspectives Rev Urol 2016; 18(1):1- 9. PMID: 27162506. Full Text

Dalela D, Karabon P, Sammon J, Sood A, Loppenberg B, Trinh QD, Menon M, and Abdollah F. Generalizability of the prostate cancer intervention versus observation trial (PIVOT) results to contemporary North American men with prostate cancer Eur Urol 2016;PMID: 27638094. Full Text

Dalela D, Karabon P, and Abdollah F. Androgen deprivation therapy and dose-escalated radiotherapy for intermediate- and high-risk prostate cancer: Sign of changing times? JAMA Oncol 2016;PMID: 27893042. Full Text

Dalela D, Jindal T, Menon M, and Abdollah F. Improved survival with local treatment of prostate cancer in men with metastatic disease: Look before you leap J Clin Oncol 2016:Jco2016696617. PMID: 27937094. Full text

Dangle PP, Akhavan A, Odeleye M, Avery D, Lendvay T, Koh CJ, Elder JS, Noh PH, Bansal D, Schulte M, MacDonald J, Shukla A, Kim C, Herbst K, Corbett S, Kearns J, Kunnavakkam R, and Gundeti MS. Ninety-day perioperative complications of pediatric robotic urological surgery: A multi- institutional study J Pediatr Urol 2015;PMID: 26897324. Full Text

Day KC, Lorenzatti Hiles G, Kozminsky M, Dawsey SJ, Paul A, Broses LJ, Shah R, Kunju LP, Hall C, Palanisamy N, Daignault-Newton S, El-Sawy L, Wilson SJ, Chou A, Ignatoski KM, Keller ET, Thomas DG, Nagrath S, Morgan TM, and Day ML. HER2 and EGFR overexpression support metastatic progression of prostate cancer to bone Cancer Res 2016;PMID: 27793843. Full Text

Den RB, Santiago-Jimenez M, Alter J, Schliekelman M, Wagner JR, Renzulli Ii JF, Lee DI, Brito CG, Monahan K, Gburek B, Kella N, Vallabhan G, Abdollah F, Trabulsi EJ, Lallas CD, Gomella LG, Woodlief TL, Haddad Z, Lam LL, Deheshi S, Wang Q, Choeurng V, du Plessis M, Jordan J, Parks B, Shin H, Buerki C, Yousefi K, Davicioni E, Patel VR, and Shah NL. Decipher correlation patterns post prostatectomy: initial experience from 2,342 prospective patients Prostate Cancer Prostatic Dis 2016;PMID: 27574020. Article Request Form

East E, Fullen DR, Arps D, Patel RM, Palanisamy N, Carskadon S, and Harms PW. Morpheaform basal cell carcinomas with areas of predominantly single-cell pattern of infiltration: Diagnostic utility of p63 and cytokeratin Am J Dermatopathol 2016;PMID: 27043336. Full Text

Fontugne J, Davis K, Palanisamy N, Udager A, Mehra R, McDaniel AS, Siddiqui J, Rubin MA, Mosquera JM, and Tomlins SA. Clonal evaluation of prostate cancer foci in biopsies with discontinuous tumor involvement by dual ERG/SPINK1 immunohistochemistry Mod Pathol 2016; 29(2):157-165. PMID: 26743468. Full Text

Fossati N, Larcher A, Briganti A, and Abdollah F. The Authors Respond J Natl Compr Canc Netw 2016; 14(2):117-122. PMID: 26850481. Article Request Form

132 Freedland SJ, Choeurng V, Howard L, De Hoedt A, du Plessis M, Yousefi K, Lam LL, Buerki C, Ra S, Robbins B, Trabulsi EJ, Shah NL, Abdollah F, Feng FY, Davicioni E, Dicker AP, Karnes RJ, and Den RB. Utilization of a genomic classifier for prediction of metastasis following salvage radiation therapy after radical prostatectomy Eur Urol 2016;PMID: 26806658. Full Text

Ghani KR, Miller DC, Linsell S, Brachulis A, Lane B, Sarle R, Dalela D, Menon M, Comstock B, Lendvay TS, Montie J, and Peabody JO. Measuring to improve: Peer and crowd-sourced assessments of technical skill with robot-assisted radical prostatectomy Eur Urol 2016;PMID: 26755338. Full Text

Griffin MA, Janosek-Albright KJ, Diaz-Insua M, Elshatanoufy S, and Atiemo HO. Quality of life outcomes in peri- urethral calcium hydroxylapatite injection Int Urogynecol J 2016;PMID: 27250833. Full Text

Hanske J, Meyer CP, Sammon JD, Choueiri TK, Menon M, Lipsitz SR, Noldus J, Nguyen PL, Sun M, and Trinh QD. The influence of marital status on the use of breast, cervical, and colorectal cancer screening Prev Med 2016;PMID: 27215758. Full Text

Harms PW, Hocker TL, Zhao L, Chan MP, Andea AA, Wang M, Harms KL, Wang ML, Carskadon S, Palanisamy N, and Fullen DR. Loss of p16 expression and copy number changes of CDKN2A in a spectrum of spitzoid melanocytic lesions Hum Pathol 2016;PMID: 27569296. Full Text

Hsu L, Li H, Pucheril D, Hansen M, Littleton R, Peabody J, and Sammon J. Use of percutaneous nephrostomy and ureteral stenting in management of ureteral obstruction World J Nephrol 2016; 5(2):172-181. PMID: 26981442. Full Text

Huang KC, Begin LR, Palanisamy N, Donnelly B, and Bismar TA. SPINK1 expression in relation to PTEN and ERG in matched primary and lymph node metastatic prostate cancer: Implications for biomarker development Urol Oncol 2015;PMID: 26725250. Full Text

Hussein AA, Ghani KR, Peabody J, Sarle R, Abaza R, Eun D, Hu J, Fumo M, Lane B, Montgomery J, Hinata N, Rooney D, Comstock B, Chan HK, Mane SS, Mohler JL, Wilding G, Miller D, and Guru KA. Development and validation of an objective scoring tool for robot-assisted radical prostatectomy: Prostatectomy assessment and competency evaluation (pace) J Urol 2016;PMID: 27913152. Full Text

Hussein AA, Saar M, May PR, Wijburg CJ, Richstone L, Wagner A, Wilson T, Yuh B, Redorta JP, Dasgupta P, Shamim Khan M, Menon M, Peabody JO, Hosseini A, Gaboardi F, Mottrie A, Rha KH, Hemal A, Stockle M, Kelly J, Maatman TJ, Canda AE, Wiklund P, and Guru KA. Early oncologic failure after robot-assisted radical cystectomy: Results from the international robotic cystectomy consortium J Urol 2016;PMID: 27993668. Full text

Hwang C, Sethi S, Heilbrun LK, Gupta NS, Chitale DA, Sakr WA, Menon M, Peabody JO, Smith DW, Sarkar FH, and Heath EI. Anti-androgenic activity of absorption-enhanced 3, 3'-diindolylmethane in prostatectomy patients Am J Transl Res 2016; 8(1):166-176. PMID: 27069550. Full Text

Jeong W, Kumar R, and Menon M. Past, present and future of urological robotic surgery Investig Clin Urol 2016; 57(2):75-83. PMID: 26981588. Full Text

Jindal T, Seisen T, Sood A, Menon M, and Abdollah F. The importance of adjuvant therapy in patients with node- positive prostate cancer: A nationwide validation study Urol Oncol 2016;PMID: 27575918. Full Text

Kryvenko ON, Diaz M, Matoso A, Kates M, Cohen J, Swanson GP, and Epstein JI. Psa mass density - a measure predicting prostate cancer volume and accounting for overweight and obesity: Related psa hemodilution Urology 2016;PMID: 26773349. Full Text

Leavitt DA, Motamedinia P, Moran S, Siev M, Zhao PT, Theckumparampil N, Fakhoury M, Elsamra S, Hoenig D, Smith A, and Okeke Z. Can activities of daily living predict complications following percutaneous nephrolithotomy? J Urol 2016; 195(6):1805-1809. PMID: 26721225. Full Text

133 Lee HJ, Yousefi K, Haddad Z, Abdollah F, Lam LL, Shin H, Alshalalfa M, Godebu E, Wang S, Shabaik A, Davicioni E, and Kane CJ. Evaluation of a genomic classifier in radical prostatectomy patients with lymph node metastasis Res Rep Urol 2016; 8:77-84. PMID: 27419104. Full Text

Leow JJ, Chang SL, Meyer CP, Wang Y, Hanske J, Sammon JD, Cole AP, Preston MA, Dasgupta P, Menon M, Chung BI, and Trinh QD. Robot-assisted versus open radical prostatectomy: A contemporary analysis of an all-payer discharge database Eur Urol 2016;PMID: 26874806. Full Text

Leyh-Bannurah SR, Gazdovich S, Budaus L, Zaffuto E, Dell'Oglio P, Briganti A, Abdollah F, Montorsi F, Schiffmann J, Menon M, Shariat SF, Fisch M, Chun F, Graefen M, and Karakiewicz PI. Population- based external validation of the updated 2012 partin tables in contemporary north american prostate cancer patients Prostate 2016;PMID: 27683103. Full Text

Lieberman L, Barod R, Tapper A, Kumar R, and Rogers C. Robotic nephrectomy for central renal tumors with intraoperative evaluation of tumor histology J Robot Surg 2016;PMID: 27146858. Full Text

Lieberman L, Barod R, Dalela D, Insua M, Abaza R, Adshead J, Ahlawat R, Challacombe B, Dasgupta P, Gandaglia G, Moon DA, Novara G, Porpiglia F, Mottrie A, Bhandari M, and Rogers CG. Use of main renal artery clamping predominates over minimal clamping techniques during robotic partial nephrectomy for complex tumors J Endourol 2016;PMID: 27936928. Full text

Loppenberg B, Dalela D, Karabon P, Sood A, Sammon JD, Meyer CP, Sun M, Noldus J, Peabody JO, Trinh QD, Menon M, and Abdollah F. The impact of local treatment on overall survival in patients with metastatic prostate cancer on diagnosis: a national cancer data base analysis Eur Urol 2016;PMID: 27174537. Full Text

Lovegrove C, Novara G, Mottrie A, Guru KA, Brown M, Challacombe B, Popert R, Raza J, Van der Poel H, Peabody J, Dasgupta P, and Ahmed K. Structured and modular training pathway for robot- assisted radical prostatectomy (rarp): Validation of the rarp assessment score and learning curve assessment Eur Urol 2016; 69(3):526-535. PMID: 26585582. Full Text

Lovegrove C, Ahmed K, Novara G, Guru K, Mottrie A, Challacombe B, der Poel HV, Peabody J, and Dasgupta P. Modular training for robot-assisted radical prostatectomy: Where to begin? J Surg Educ 2016;PMID: 27932307. Full text

Macki M, and Dabaja AA. Literature review of vaccine-related adverse events reported from HPV vaccination in randomized controlled trials Basic Clin Androl 2016; 26:16. PMID: 27895921. Full Text

Majumder M, House R, Palanisamy N, Qie S, Day TA, Neskey D, Diehl JA, and Palanisamy V. RNA- binding protein FXR1 regulates p21 and TERC RNA to bypass p53-mediated cellular senescence in OSCC PLoS Genet 2016; 12(9):e1006306. PMID: 27606879. Full Text

Mani RS, Amin MA, Li X, Kalyana-Sundaram S, Veeneman BA, Wang L, Ghosh A, Aslam A, Ramanand SG, Rabquer BJ, Kimura W, Tran M, Cao X, Roychowdhury S, Dhanasekaran SM, Palanisamy N, Sadek HA, Kapur P, Koch AE, and Chinnaiyan AM. Inflammation-induced oxidative stress mediates gene fusion formation in prostate cancer Cell Rep 2016; 17(10):2620-2631. PMID: 27926866. Full text

Maurice MJ, Kaouk J, Ramirez D, Bhayani S, Allaf ME, Rogers CG, and Stifelman MD. Robotic partial nephrectomy for posterior tumors via a retroperitoneal approach offers decreased length of stay compared to the transperitoneal approach: A propensity-matched analysis J Endourol 2016;PMID: 27927035. Full text

Meyer CP, Hansen J, Boehm K, Tilki D, Abdollah F, Trinh QD, Fisch M, Sauter G, Graefen M, Huland H, Chun FK, and Ahyai SA. Tumor volume improves the long-term prediction of biochemical recurrence-free survival after radical prostatectomy for localized prostate cancer with positive surgical margins World J Urol 2016;PMID: 27260503. Full Text

Ng AM, Shah PH, and Leavitt DA. Headache and facial swelling JAMA Surg 2016;PMID: 27008236. Full Text 134 Pennell CP, Hirst AD, Campbell WB, Sood A, Agha RA, Barkun JS, and McCulloch P. Practical guide to the idea, development and exploration stages of the IDEAL framework and recommendations Br J Surg 2016;PMID: 26865013. Full Text

Ross AE, Den RB, Yousefi K, Trock BJ, Tosoian J, Davicioni E, Thompson DJ, Choeurng V, Haddad Z, Tran PT, Trabulsi EJ, Gomella LG, Lallas CD, Abdollah F, Feng FY, Klein EA, Dicker AP, Freedland SJ, Karnes RJ, and Schaeffer EM. Efficacy of post-operative radiation in a prostatectomy cohort adjusted for clinical and genomic risk Prostate Cancer Prostatic Dis 2016;PMID: 27136742. Article Request Form

Sarveswaran S, Ghosh R, Morisetty S, and Ghosh J. MK591, a second generation leukotriene biosynthesis inhibitor, prevents invasion and induces apoptosis in the bone-invading C4-2B human prostate cancer cells: implications for the treatment of castration-resistant, bone-metastatic prostate cancer PLoS One 2015; 10(4):e0122805. PMID: 25875826. Full Text

Sarveswaran S, Ghosh R, Parikh R, and Ghosh J. Wedelolactone, an anti-inflammatory botanical, interrupts c-myc oncogenic signaling and synergizes with enzalutamide to induce apoptosis in prostate cancer cells Mol Cancer Ther 2016; 15(11):2791-2801. PMID: 27474149. Article Request Form

Sarveswaran S, Varma N, Morisetty S, and Ghosh J. Inhibition of 5-lipoxygenase downregulates stemness and kills prostate cancer stem cells by triggering apoptosis via activation of c-Jun N- terminal kinase Oncotarget 2016;PMID: 27880719. Full Text

Schmid M, Krishna N, Ravi P, Meyer CP, Becker A, Dalela D, Sood A, Chun FK, Kibel AS, Menon M, Fisch M, Trinh QD, and Sun M. Trends of acute kidney injury after radical or partial nephrectomy for renal cell carcinoma Urol Oncol 2016;PMID: 27033047. Full Text

Seisen T, Jindal T, Karabon P, Sood A, Bellmunt J, Roupret M, Leow JJ, Vetterlein MW, Sun M, Alanee S, Choueiri TK, Trinh QD, Menon M, and Abdollah F. Efficacy of systemic chemotherapy plus radical nephroureterectomy for metastatic upper tract urothelial carcinoma Eur Urol 2016;PMID: 27912971. Full Text

Seisen T, and Abdollah F. Surgery-based multimodal management of high-risk prostate cancer patients: What is the functional price to pay for optimal disease control? Eur Urol 2016;PMID: 27955904. Full text

Smith SC, Palanisamy N, Martin E, Almenara J, McHugh JB, Choi EK, Lucas DR, Betz BL, Thomas D, and Patel RM. The utility of ETV1, ETV4, and ETV5 RNA in situ hybridization in the diagnosis of CIC-DUX4 sarcomas Histopathology 2016;PMID: 27790742. Full Text

Sood A, Abdullah NM, Abdollah F, Abouljoud MS, Trinh QD, Menon M, and Sammon JD. Rates of kidney transplantation from living and deceased donors for blacks and whites in the united states, 1998 to 2011 JAMA Intern Med 2015; 175(10):1716-1718. PMID: 26322565. Full Text

Sood A, Majumder K, Kachroo N, Sammon JD, Abdollah F, Schmid M, Hsu L, Jeong W, Meyer CP, Hanske J, Kalu R, Menon M, and Trinh QD. Adverse event rates, timing of complications, and the impact of specialty on outcomes following adrenal surgery: An analysis of 30-day outcome data from the american college of surgeons national surgical quality improvement program (acs-nsqip) Urology 2015;PMID: 26743396. Full Text

Sood A, Hemal AK, Assimos DG, Peabody JO, Menon M, and Ghani KR. Robotic anatrophic nephrolithotomy utilizing near infrared fluorescence image-guidance: Idea, development, exploration, assessment, long-term monitoring (ideal) stage 0 animal model study Urology 2016;PMID: 27210569. Full Text

Sood A, Klett DE, Abdollah F, Sammon JD, Pucheril D, Menon M, Jeong W, and Peabody JO. Robot-assisted partial cystectomy with intraoperative frozen section examination: Evolution and evaluation of a novel technique Investig Clin Urol 2016; 57(3):221-228. PMID: 27195322. Full Text

Sood A, Li H, Suson KD, Majumder K, Sedki M, Abdollah F, Sammon JD, Friedman A, Loppenberg B, Lakshmanan Y, Trinh QD, and Elder JS. Treatment patterns, testicular loss, and 135 disparities in inpatient surgical management of testicular torsion in boys: a population based study 1998-2010 BJU Int 2016;PMID: 27322784. Full Text

Sood A, Abdollah F, and Menon M. Je le pansai, Dieu le guerit Eur Urol 2016;PMID: 27720535. Full Text

Sood A, Abdollah F, Sammon JD, Arora N, Weeks M, Peabody JO, Menon M, and Trinh QD. Postoperative sepsis prediction in patients undergoing major cancer surgery J Surg Res 2016; 209:60- 69. PMID: 28032572. Full text

Thamilselvan V, Menon M, and Thamilselvan S. Combination of carmustine and selenite effectively inhibits tumor growth by targeting androgen receptor, androgen receptor-variants and Akt in preclinical models: New hope for patients with prostate cancer Int J Cancer 2016;PMID: 27198552. Full Text

Trinh QD, Li H, Meyer CP, Hanske J, Choueiri TK, Reznor G, Lipsitz SR, Kibel AS, Han PK, Nguyen PL, Menon M, and Sammon JD. Determinants of cancer screening in Asian-Americans Cancer Causes Control 2016;PMID: 27372292. Full Text

Trinh VQ, Ravi P, Abd-El-Barr AE, Jhaveri JK, Gervais MK, Meyer CP, Hanske J, Sammon JD, and Trinh QD. Pneumonia after major cancer surgery: Temporal trends and patterns of care Can Respir J 2016; 2016:6019416. PMID: 27445554. Full Text

Walz J, Epstein JI, Ganzer R, Graefen M, Guazzoni G, Kaouk J, Menon M, Mottrie A, Myers RP, Patel V, Tewari A, Villers A, and Artibani W. A critical analysis of the current knowledge of surgical anatomy of the prostate related to optimisation of cancer control and preservation of continence and erection in candidates for radical prostatectomy: An update Eur Urol 2016;PMID: 26850969. Full Text

Wang L, Diaz M, Stricker H, Peabody JO, Menon M, and Rogers CG. Adding a newly trained surgeon into a high- volume robotic prostatectomy group: are outcomes ? J Robot Surg 2016;PMID: 27350553. Full Text

Wang L, Diaz M, Stricker H, Peabody JO, Menon M, and Rogers CG. Erratum to: Adding a newly trained surgeon into a high-volume robotic prostatectomy group: are outcomes compromised? J Robot Surg 2016;PMID: 27743311. Full Text

Williamson SR, Eble JN, and Palanisamy N. Sclerosing TFEB rearrangement renal cell carcinoma: A recurring histologic pattern Hum Pathol 2016;PMID: 27864122. Full Text

Williamson SR, Grignon DJ, Cheng L, Favazza L, Gondim DD, Carskadon S, Gupta NS, Chitale DA, Kalyana- Sundaram S, and Palanisamy N. Renal cell carcinoma with chromosome 6p amplification including the tfeb gene: A novel mechanism of tumor pathogenesis? Am J Surg Pathol 2016;PMID: 28009604. Full text

Yoon HJ, Shanker A, Wang Y, Kozminsky M, Jin Q, Palanisamy N, Burness ML, Azizi E, Simeone DM, Wicha MS, Kim J, and Nagrath S. Tunable thermal-sensitive polymer-graphene oxide composite for efficient capture and release of viable circulating tumor cells Adv Mater 2016;PMID: 27115557. Article Request Form

Zaffuto E, Gazdovich S, Leyh-Bannurah SR, Huland H, Abdollah F, Shariat SF, Menon M, Briganti A, Montorsi F, and Karakiewicz PI. Contemporary rates of pathological features and mortality for adenocarcinoma of the urinary bladder in the USA Int J Urol 2016;PMID: 27875858. Full Text

Zhang Z, Shiratsuchi H, Palanisamy N, Nagrath S, and Ramnath N. Expanded ctcs from a patient with alk positive lung cancer present eml4-alk rearrangement along with resistance mutation and enable drug sensitivity testing: A case study J Thorac Oncol 2016;PMID: 27507192. Article Request Form

136 Henry Ford Health System 2016 Abstracts List

ANESTHESIOLOGY

Aljasmi M, Kareem Uduman A, Gashouta M, Wong H, Bazan L, Mordis C, and Roehrs T. CPAP in OSA patients and post-operative outcomes Chest 2016; 150(4):1279A. PMID: Not assigned. Abstract

El-Bashir J, Dalela S, Owaduge I, and Hommel D. Do not touch the heart ... Please Transplantation 2016; 100:S158-S158. PMID: Not assigned. Abstract

Kaveeshvar H, Kashouty R, and Loomba V. Spontaneous carotid dissection in a patient after incidental amphetamine salt overdose presenting as cluster like headache Neurology 2016; 86(16)PMID: Not assigned. Abstract

Zahoor S, Kaveeshvar H, and Loomba V. Pain as the presenting symptom of primary progressive multiple sclerosis Neurology 2016; 86(16)PMID: Not assigned. Abstract

137 BEHAVIORAL HEALTH SERVICES

Bryce K, Pehote M, and Lanfear D. Cognitive functioning and post-lvad outcomes:Influence of comorbidities and specific cognitive domains J Card Fail 2016; 22(8):S124-S124. PMID: Not assigned. Abstract

Jesse M, Abouljoud M, Eshelman A, DeReyck C, and Lerut J. American and european transplant surgeons: Research, teaching, and burnout Am J Transplant 2016; 16:790. PMID: Not assigned. Abstract

McIlvennan CK, Bryce K, Lindenfeld J, Allen LA, and Lanfear DE. Assessment of cognitive function prior to and after implantation of left ventricular assist device J Heart Lung Transplant 2016; 35(4):S165-S166. PMID: Not assigned Abstract

Rebhan N, Bebanic M, Yoshida A, Macaulay T, Goldstein E, Ho CX, Eshelman A, Abouljoud M, Jesse M, and Rizzari M. Psychiatric characteristics of acute liver failure patients: Acetaminophen overdose versus other etiologies Am J Transplant 2016; 16:524. PMID: Not assigned. Abstract

138 CENTER FOR HEALTH POLICY AND HEALTH SERVICES RESEARCH

Cajigal S, Peterson EL, Wells KE, Zoratti EM, Lanfear DE, Seibold M, Rajesh K, Burchard EG, and Williams LK. Asthma control test composite score may not be superior to assessments of rescue inhaler use for predicting severe asthma exacerbations J Allergy Clin Immunol 2016; 137(2):AB207. PMID: Not assigned. Abstract

Michaels AT, Radjef R, She RC, Liu B, Peterson E, Pinto Y, Williams K, Sabbah H, and Lanfear D. Improving risk prediction in heart failure: MAGGIC plus natriuretic peptides J Card Fail 2016; 22(8):S99- S99. PMID: Not assigned. Abstract

Radjef R, Michaels A, Peterson E, She R, Liu B, Williams K, Sabbah H, and Lanfear D. Performance of MAGGIC score in african americans compared to whites J Card Fail 2016; 22(8):S101- S101. PMID: Not assigned. Abstract

Rajesh K, Cho SH, Min JY, Kang J, Chan W, Kim DY, Oh S, Torgerson D, Del Mar Del-Pino-Yanes M, Hu D, Sen S, Huntsman S, Eng C, Farber HJ, Rodriguez-Cintron W, Rodriguez-Santana J, Serebrisky D, Thyne S, Borrell L, Williams LK, Seibold M, Burchard EG, and Avila PC. PAI-1, early life infections and asthma risk, exacerbations, and reduced lung function J Allergy Clin Immunol 2016; 137(2):AB178. PMID: Not assigned. Abstract

139 DERMATOLOGY

Boguniewicz M, Paller AS, Tom WL, Lebwohl MG, Blumenthal RL, Call RS, Eichenfield LF, Forsha DW, Rees WC, Simpson EL, Stein Gold LF, Zaenglein AL, Hughes MH, Zane LT, and Hebert AA. Efficacy and safety of crisaborole topical ointment, 2%, a novel, nonsteroidal, topical, anti-inflammatory, phosphodiesterase inhibitor in 2 phase 3 studies in children and adults with mildto-moderate atopic dermatitis J Allergy Clin Immunol 2016; 137(2):AB397. PMID: Not assigned. Abstract

Cheng C, Ozog D, Chaffins M, Ginsberg D, and Krakowski A. Ablative fractional resurfacing for treatment of focal dermal hypoplasia in a pediatric patient with goltz syndrome Lasers Surg Med 2016; 48(4):428-428. PMID: Not assigned. Abstract

Eichenfield L, Call R, Forsha D, Fowler J, Hebert A, Spellman M, Stein-Gold L, Syoc MV, Zane L, and Tschen E. Long- term safety of crisaborole in children and adults with mild-to-moderate atopic dermatitis Pediatr Dermatol 2016; 33:S46-S47. PMID: Not assinged. Abstract

Eichenfield L, Call RS, Forsha D, Fowler J, Hebert AA, Spellman M, Stein-Gold L, Van Syoc M, Zane LT, and Tschen EH. Long-term safety of crisaborole topical ointment, 2%, in atopic dermatitis J Invest Dermatol 2016; 136(5):S49- S49. PMID: Not assigned. Abstract

Foley P, Stein-Gold L, Kircik L, Fowler J, Jackson M, Tan J, Draleos Z, Fleischer A, Appell M, Steinhoff M, Lynde C, Hong L, and Jacovella J. Ivermectin 1% Cream, an effective and safe topical treatment of inflammatory lesions of papulopustular rosacea Australas J Dermatol 2016; 57:32-32. PMID: Not assigned. Abstract

Hamzavi I. The role of laser therapy Exp Dermatol 2016; 25:8-8. PMID: Not assigned. Abstract

Levoska MA, Jansen R, Jacobsen G, Jahnke M, Hekman D, and Eide M. Decreasing pediatric skin biopsy rates of lesions that were pigmented in a large health system J Invest Dermatol 2016; 136(5):S36-S36. PMID: Not assigned. Abstract

Modh A, McHargue CA, Lim H, and Siddiqui F. Single-fraction radiation therapy provides highly effective palliation for cutaneous t-cell lymphoma Int J Radiat Oncol Biol Phys 2016; 96(2s):E492. PMID: 27674835. Full Text Abstract

Paller A, Tom W, Lebwohl M, Blumenthal R, Boguniewicz M, Call R, Eichenfield L, Forsha D, Rees W, Simpson E,Stein-Gold L, Zaenglein A, Spellman M, Zane L, and Hebert A. Two phase 3 studies in atopic dermatitis with crisaborole, the novel, nonsteroidal topical phosphodiesterase 4 inhibitor Pediatr Dermatol 2016; 33:S19. PMID: Not assigned. Abstract

Paul C, Stein-Gold L, Cambazard F, Kalb RE, Lowson D, Moller AH, and Griffiths CEM. More rapid improvement in quality of life with fixed-combination calcipotriene plus betamethasone dipropionate aerosol foam vs. topical suspension (PSO-ABLE study in patients with psoriasis vulgaris) Br J Dermatol 2016; 175:213-214. PMID: Not assigned. Abstract

Riyaz F, and Ozog D. A review of confocal microscopy for inflammatory skin disorders Lasers Surg Med 2016; 48:34-34. PMID: Not assigned. Abstract

Yin C, Weiland M, Li J, She R, Zhou L, and Mi Q. Serum miRNAs as potential biomarkers for early prediction of type 1 diabetes FASEB Journal 2016; 30PMID: Not assigned. Abstract

Zane LT, Eichenfield LF, Call RS, Forsha DW, Fowler JF, Hebert AA, Spellman M, Stein-Gold L, Van Syoc M, and Tschen EH. Long-term safety of Crisaborole Topical Ointment, 2%, in children and adults with mild-to-moderate atopic dermatitis J Immunol 2016; 196PMID: Not assigned. Abstract

Zane LT, Paller AS, Tom WL, Lebwohl MG, Blumenthal RL, Boguniewicz M, Call RS, Eichenfield LF, Forsha DW, Rees WC, Simpson EL, Stein-Gold L, Zaenglein AL, and Hebert AA. Two phase 3 study results of children and adults with mild-to-moderate atopic dermatitis treated with Crisaborole Topical Ointment, 2%, a novel, nonsteroidal, topical, anti-inflammatory, phosphodiesterase 4 inhibitor J Immunol 2016; 196PMID: Not assigned Abstract

140 DIAGNOSTIC RADIOLOGY

Aljundi L, Miller N, Taylor A, Hung J, and Hwang C. Time to castration-resistance and docetaxel outcomes in metastatic prostate cancer J Clin Oncol 2016; 34PMID: Not assigned. Abstract

Carlyle L, Wang DD, Taylor A, Swanson B, Wyman J, Pantelic M, Song T, Eng M, Paone G, Greenbaum A, and O'Neill W. No two systoles the same: Personalizing transcatheter heart valve selection for transcatheter aortic valve replacement J Am Coll Cardiol 2016; 67(13):327. PMID: Not assigned. Abstract

Joshi S, Vanderhoek M, and Harkness B. CdZnTe detectors: What you need to know J Nucl Med 2016; 57PMID: Not assigned. Abstract

Kupsky D, Wang DD, Eng M, Song T, Pantelic M, Nadig J, Greenbaum A, and O'Neill W. TCT- 621 Left atrial appendage characteristics evaluated by computed tomography following closure with Watchman device J Am Coll Cardiol 2016; 68(18s):B253. PMID: 27969997. Abstract

Morrison J, Jahangiri Y, Vance L, McVinnie D, and Farsad K. Characterization of iodide-induced sialadenitis: Pooled cohort analysis of case reports J Vasc Interv Radiol 2016; 27(3):S120-S121. PMID: Not assigned. Abstract

Patel K, Le M, Achakzai B, Paidpally V, Jaber M, Danier S, Shah K, Harvill M, Critchfield J, and Saad W. Normal postablative changes vs. residual/ recurrent tumor: How to tell them apart on imaging? J Vasc Interv Radiol 2016; 27(3):S276. PMID: Not assigned. Abstract

Patel K, Le M, Yu H, Achakzai B, Paidpally V, Jaber M, Kakos R, Danier S, Shah K, Harvill M, Critchfield J, and Saad W. Do no harm: Advanced protective techniques during image-guided percutaneous thermal ablation of renal tumors J Vasc Interv Radiol 2016; 27(3):S243. PMID: Not assigned. Abstract

Riaz R, Achakzai B, and Getzen T. Effectiveness of yttrium-90 radioembolization delivery: Comparison of microcatheter flow dynamics and residual activity J Vasc Interv Radiol 2016; 27(3):S67. PMID: Not assigned. Abstract

Rinker E, Rodriguez E, Vanderhoek M, Bevins N, and Schwartz S. Radiation exposure in radial versus femoral artery access in interventional radiology J Vasc Interv Radiol 2016; 27(3):S143- S144. PMID: Not assigned. Abstract

Sever A, Rheinboldt M, Scher C, DelProposto Z, and Klochko C. Multimodality imaging of gout: A review of characteristic features with attention to recent developments in imaging diagnosis Emergency Radiology 2016; 23(6):573. PMID: Not assigned. Abstract

Small B, Mitchell G, Hrabec D, Selim R, and Wang DD. Hyperandrogenism and spontaneous coronary artery dissection: A new entity? Chest 2016; 150(4):89A. PMID: Not assigned. Abstract

Spain JA, Rheinboldt M, and DelProposto Z. Acute biliary inflammation and secondary complications: The gamut of MDCT imaging findings Emergency Radiology 2016; 23(6):572- 573. PMID: Not assigned. Abstract

Stone M, Parrish D, Rheinboldt M, DelProposto Z, and Doshi P. Beyond trauma: The gamut of acute inflammatory and vascular spinal emergencies Emergency Radiology 2016; 23(6):570-571. PMID: Not assigned. Abstract

141 EMERGENCY MEDICINE

Arbit B, Sharma S, Clopton P, Mueller C, Nowak R, McCord J, Mockel M, Filippatos G, Daniels L, Di Somma S, and Maisel A. Influence of gender and copeptin levels on clinical outcomes in patients with acute heart failure J Card Fail 2016; 22:S29. PMID: Not assigned. Abstract

Cheung WL, Chopp M, Zhang T, Zhang ZG, and Morris D. Irisin induces neurite outgrowth in primarycortical neurons Brain Injury 2016; 30(5-6):497-498. PMID: Not assigned. Abstract

Haley L, Buekers TE, Burmeister C, and Elshaikh MA. Older age is no longer an adverse prognostic factor in women with early-stage endometrial carcinoma: A matched analysis Gynecol Oncol 2016; 141:70-71. PMID: Not assigned. Abstract

Jaehne AK, Rivers EP, Poissons LK, Chen Y, Gill J, Deledda J, and Suarez A. Plasma proteome in patients with vasopressor dependent septic shock Shock 2016; 45(6):131. PMID: Not assigned. Abstract

Jain T, Nowak R, Hudson M, Frisoli T, Jacobsen G, Tabaku M, and McCord J. Short and long- term prognostic utility of the heart score in patients presenting to the emergency department with undifferentiated chest pain JAm Coll Cardiol 2016; 67(13):513. PMID: Not assigned. Abstract

Miller J, Thompson R, Akhtar S, Jackson P, Goldberg J, Bitrus R, and Lewandowski C. Pumping against gravity - cardiac function affects fluctuations in cerebral blood flow caused by head position change in acute ischemic stroke Stroke 2016; 47PMID: Not assigned. Abstract

Morris D, Chopp M, Cheung WL, Cui Y, Zhang T, Lu M, Zhang L, and Zhang ZG. Thymosin β4 for the treatment of sub-acute stroke in aged rats Stroke 2016; 47PMID: Not assigned. Abstract

Muller CC, McCord J, Michaels A, Nowak R, Giannitsis E, Body R, Christ M, Lindahl B, DeFilippi C, Christenson R, Bendig G, Jacobsen G, and Mueller C. Symptoms predictive of acute myocardial infarction in the troponin era: Analysis from the TRAPID-AMI study J Am Coll Cardiol 2016; 67(13):518. PMID: Not assigned. Abstract

Nagarwala J, Dev S, and Markin A. The vomiting patient. Small bowel obstruction, cyclic vomiting, and gastroparesis Emerg Med Clin North Am 2016;PMID: Not assigned. Abstract

Small B, Mitchell G, Hrabec D, Selim R, and Wang DD. Hyperandrogenism and spontaneous coronary artery dissection: A new entity? Chest 2016; 150(4):89A. PMID: Not assigned. Abstract

Tirgari S, Markin A, and Kobylak L. Large mature teratoma presenting as incidental mediastinal mass on chest radiograph Chest 2016; 150(4):806A. PMID: Not assigned. Abstract

142 GLOBAL HEALTH INITIATIVE

Dankerlui D, Parke D, Prentiss T, Zervos J, Plum A, Tamler I, Kaljee L, and Kilgore P. Henry ford health system global health initiative’s ‘research training to research project model.’ CUGH Global Health Conference 2016;PMID: Not assigned - Abstract.

Plum AJ, Mucha R, Tamler I, Zervos JM, Hammer PJ. Applying the United Nations Sustainable Development Goals in the United States as a Framework for Local Action in Low-Income Communities: A Workshop Forum for Sustainable Development in Detroit, Michigan Twelfth International Conference on Environmental, Cultural, Economic, and Social Sustainability 2016;PMID: Not assigned - Abstract.

GRADUATE MEDICAL EDUCATION

Bourgi K, Brar I, and Baker-Genaw K. Hepatitis C screening and linkage to care at a comprehensive health system Topics in Antiviral Medicine 2016; 24(E-1):209. PMID: Not assigned. Abstract

Chasteen K, Awdish R, Mendez M, Buick D, and Kokas M. Clear conversations: A comprehensive curriculum to facilitate translation of skills learned in simulated settings to improve communication in real clinical encounters J Pain Symptom Manage 2016; 51(2):384-385. PMID: Not assigned. Abstract

143 INTERNAL MEDICINE

Allergy and Immunology

Brown KR, Zabel RA, Calatroni A, Visness C, Sivaprasad U, Matsui E, West JB, Makhija MM, Gill MA, Kim H, Kattan M, Pillai DK, Gern JE, Busse WW, Togias A, Liu AH, and Khurana Hershey GK. Endotypes of difficult-to-control asthma in inner city children differ by race J Allergy Clin Immunol 2016; 137(2):AB177. PMID: Not assigned. Abstract

Cajigal S, Peterson EL, Wells KE, Zoratti EM, Lanfear DE, Seibold M, Rajesh K, Burchard EG, and Williams LK. Asthma control test composite score may not be superior to assessments of rescue inhaler use for predicting severe asthma exacerbations J Allergy Clin Immunol 2016; 137(2):AB207. PMID: Not assigned. Abstract

Esquivel AT, Busse WW, Calatroni A, Gergen PJ, Grindle K, Gruchalla RS, Kattan M, Kercsmar C, Khurana Hershey GK, Kim H, Lebeau P, Liu AH, Szefler SJ, Teach SJ, Pongracic JA, West JB, Wildfire J, and Gern JE. Omalizumab decreases rates of cold symptoms in Inner-City children with allergic asthma J Allergy Clin Immunol 2016; 137(2):AB87. PMID: Not assigned. Abstract

Liu AH, Babineau DC, Zabel RA, Zoratti EM, Pongracic JA, O'Connor GT, Wood RA, Khurana Hershey GK, Kercsmar C, Gruchalla RS, Kattan M, Teach SJ, Arbes Jr SJ, Gergen PJ, Togias A, Visness C, and Busse WW. Identification of pathways to asthma severity in inner-city children J Allergy Clin Immunol 2016; 137(2):AB10. PMID: Not assigned. Abstract

Luria CJ, Sitarik AR, Havstad S, Wegienka GR, Kim H, Zoratti EM, Joseph CLM, and Andrea Cassidy B. Association between asthma symptom scores and increased perceived stress and trait anxiety in asthmatic adolescents J Allergy Clin Immunol 2016; 137(2):AB11. PMID: Not assigned. Abstract

Pongracic JA, Zabel RA, Babineau DC, Zoratti EM, O'Connor GT, Wood RA, Khurana Hershey GK, Kercsmar C, Gruchalla RS, Kattan M, Teach SJ, Arbes Jr SJ, Busse WW, Gergen PJ, Togias A, Visness C, and Liu AH. Characteristics that distinguish difficult-to-control asthma in inner-city children J Allergy Clin Immunol 2016; 137(2):AB8. PMID: Not assigned. Abstract

Wells KE, Kim H, Havstad S, and Woodcroft KJ. Trends in asthma-related pharmacy fills Pharmacoepidemiol Drug Saf 2015; 24:139-140. PMID: Not assigned. Abstract

Zoratti EM, Zabel RA, Babineau DC, Pongracic JA, O'Connor GT, Wood RA, Khurana Hershey GK, Kercsmar C, Gruchalla RS, Kattan M, Teach SJ, Arbes Jr SJ, Visness C, Busse WW, Gergen PJ, Togias A, and Liu AH. Levels of allergy cluster with asthma severity in inner-city children J Allergy Clin Immunol 2016; 137(2):AB103. PMID: Not assigned. Abstract

144 Cardiology/Cardiovascular Research

Ahmed H, Zhao D, Guallar E, Blaha MJ, Brawner CA, Keteyian SJ, Al-Mallah MH, and Michos ED. Gender and fitness status influence age-related decline in peak heart rate achievement: Insight from the fit cohort Circulation 2016; 133PMID: Not assigned. Abstract

Alame A, Karmpaliotis D, Alaswad K, Jaffer F, Yeh R, Wyman RM, Patel M, Bahadorani J, Lombardi W, Grantham JA, Kandzari D, Lembo N, Moses J, Kirtane A, Toma C, Doing A, Choi J, Uretsky B, Karacsonyi J, Resendes E, Nguyen-Trong PK, Martinez-Parachini JR, Karatasakis A, Danek BA, Rangan B, Thompson C, Banerjee S, and Brilakis E. TCT-301 Outcomes of percutaneous coronary intervention in chronic total occlusions caused by in-stent restenosis: Insights from a U.S. Multicenter registry J Am Coll Cardiol 2016; 68(18s):B123-b124. PMID: 27969644. Abstract

Al-Mallah M, Qureshi W, Ahmed A, Blaha M, Brawner C, Ehrman J, and Keteyian S. Cardiorespiratory fitness predictes outcomes among patients with depression: The henry ford exercise testing (FIT) project Eur Heart J 2016; 37:37. PMID: Not assigned. Abstract

Alraies MC, Yannopoulos D, Karatasakis A, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh R, Patel M, Bahadorani J, Karacsonyi J, Alame A, Banerjee S, Brilakis E, and Garcia S. TCT-286 Coronary artery spatial distribution of chronic total occlusions: Insights from a large us registry J Am Coll Cardiol 2016; 68(18s):B117-b118. PMID: 27969627. Abstract

Alsafadi MY, Mawri S, Shah J, Jain T, Dirani G, Nakhle A, Abdelrahim E, Michaels A, Huda N, and Ananthasubramaniam K. Inferior Vena Cava diameter as a predictor of mortality in septic shock Chest 2016; 150(4):366A. PMID: Not assigned. Abstract

Anantha Narayanan M, Gujjula N, Anugula D, Reddy YN, Baskaran J, and Raveendran G. Tct-203 dual versus triple anti thrombotic therapy in acute coronary syndromes - a meta analysis J Am Coll Cardiol 2016; 68(18s):B82-b83. PMID: 27970374. Abstract

Anantha Narayanan M, Reddy YN, Gujjula N, Anugula D, Baskaran J, Delcore M, and Raveendran G. TCT-186 Delayed versus immediate stenting strategy in ST segment elevation myocardial infarction - A meta analysis J Am Coll Cardiol 2016; 68(18s):B76. PMID: 27970356. Abstract

Arbit B, Sharma S, Clopton P, Mueller C, Nowak R, McCord J, Mockel M, Filippatos G, Daniels L, Di Somma S, and Maisel A. Influence of gender and copeptin levels on clinical outcomes in patients with acute heart failure J Card Fail 2016; 22:S29. PMID: Not assigned. Abstract

Basir M, Khandelwal A, Dixon S, Moses J, Maini B, Grines C, Schreiber T, Ohman EM, and O'Neill W. Tct-121 mechanical circulatory support in acute myocardial infarction complicated by cardiogenic shock: Insights from the cvad registry J Am Coll Cardiol 2016; 68(18s):B49. PMID: 27970286. Abstract

Baumann RL, Wang DD, Brooks K, Panchal R, Raymond T, Andrew T, Parikh S, Zweig B, Schairer J, Eng M, Nemeh H, Ananthasubramaniam K, Greenbaum A, and O'Neill W. Echocardiographic assessment of changes in RV function in patients with mitral regurgitation undergoing mitraclip placement J Am Coll Cardiol 2016; 67(13):347. PMID: Not assigned. Abstract

Bryce K, Lanfear DE, Williams CT, Lindenfeld J, Allen LA, and McIlvennan C. Risk of death or rehospitalization after LVAD and baseline cognitive status J Heart Lung Transplant 2016; 35(4):S126-S127. PMID: Not assigned. Abstract

Bryce K, Tita C, Williams C, Morgan J, Nemeh H, Selektor Y, Borgi J, Velez M, and Lanfear D. Cognitive functioning is associated with clinical outcomes after LVAD implantation J Am Coll Cardiol 2016; 67(13):1273. PMID: Not assigned. Abstract

Bryce K, Pehote M, and Lanfear D. Cognitive functioning and post-lvad outcomes:Influence of comorbidities and specific cognitive domains J Card Fail 2016; 22(8):S124-S124. PMID: Not assigned. Abstract

145

Cajigal S, Peterson EL, Wells KE, Zoratti EM, Lanfear DE, Seibold M, Rajesh K, Burchard EG, and Williams LK. Asthma control test composite score may not be superior to assessments of rescue inhaler use for predicting severe asthma exacerbations J Allergy Clin Immunol 2016; 137(2):AB207. PMID: Not assigned. Abstract

Calmac L, Niculescu R, Badila E, Weiss E, Penes D, Zamfir D, Itu L, Lazar L, Carp M, Itu A, Suciu C, Passerini T, Sharma P, Georgescu B, and Comaniciu D. TCT-527 A data-driven approach combining image-based anatomical features and resting state measurements for the functional assessment of coronary artery disease J Am Coll Cardiol 2016; 68(18s):B212-b213. PMID: 27969893. Abstract

Carlyle L, Wang DD, Taylor A, Swanson B, Wyman J, Pantelic M, Song T, Eng M, Paone G, Greenbaum A, and O'Neill W. No two systoles the same: Personalizing transcatheter heart valve selection for transcatheter aortic valve replacement J Am Coll Cardiol 2016; 67(13):327. PMID: Not assigned. Abstract

Casida J, Pagani FD, Yarandi H, Williams C, Lefebvre M, Fox S, and Lichtenberg P. Cognitive function and self-care in patients with left ventricular assist devices (LVADs) J Heart Transplant 2016; 35(4):S344. PMID: Not assigned. Abstract

Danek BA, Karatasakis A, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Patel MP, Mahmud E, Lombardi WL, Wyman MR, Grantham JA, Doing A, Kandzari DE, Lembo NJ, Garcia S, Toma C, Moses JW, Kirtane AJ, Parikh MA, Ali ZA, Karacsonyi J, Rangan BV, Thompson CA, Banerjee S, and Brilakis ES. Development and validation of a scoring system for predicting periprocedural complications during percutaneous coronary interventions of chronic total occlusions: The prospective global registry for the study of chronic total occlusion intervention (progress cto) complications score J Am Heart Assoc 2016; 5(10)PMID: 27729332. Abstract

Danek BA, Karatasakis A, Karmpaliotis D, Alaswad K, Yeh R, Jaffer F, Patel M, Bahadorani J, Lombardi W, Wyman RM, Grantham JA, Doing A, Kandzari D, Lembo N, Garcia S, Toma C, Moses J, Kirtane A, Parikh M, Ali Z, Karacsonyi J, Alame A, Nguyen-Trong PK, Martinez-Parachini JR, Kalsaria P, Rangan B, Thompson C, Banerjee S, and Brilakis E. TCT-15 use of antegrade dissection re-entry in coronary chronic total occlusion percutaneous coronary intervention in a contemporary multicenter registry J Am Coll Cardiol 2016; 68(18s):B6-b7. PMID: 27970311. Abstract

Danek BA, Karatasakis A, Karmpaliotis D, Alaswad K, Yeh R, Jaffer F, Patel M, Bahadorani J, Lombardi W, Wyman RM, Grantham JA, Doing A, Kandzari D, Lembo N, Garcia S, Toma C, Moses J, Kirtane A, Parikh M, Ali Z, Karacsonyi J, Alame A, Nguyen-Trong PK, Martinez-Parachini JR, Kalsaria P, Rangan B, Thompson C, Banerjee S, and Brilakis E. TCT-281 Development and validation of a scoring system for predicting major adverse cardiovascular events during percutaneous coronary interventions of chronic total occlusions: The progress cto (prospective global registry for the study of chronic total occlusion intervention) mace score J Am Coll Cardiol 2016; 68(18s):B115-b116. PMID: 27969623. Abstract

Daubert MA, Yow E, Dunn G, Barnhart H, Douglas P, Udelson J, O'Connor C, Goldstein S, and Sabbah H. Effects of a novel tetrapeptide in heart failure with reduced ejection fraction (HFREF): A phase I randomized, placebo- controlled trial of elamipretide J Am Coll Cardiol 2016; 67(13):1283. PMID: Not assigned. Abstract

Eng MH, Greenbaum A, Wang DD, Wyman J, Nemeh H, Paone G, and O'Neill W. Transseptal delivery for mitral valve in valve procedures using an apical rail: Technique description and initial results J Am Coll Cardiol 2016; 67(13):335. PMID: Not assigned. Abstract

Gibbs J, Mansour M, Mawri S, Nasr Y, Sudasena D, and Ananthasubramaniam K. The value of additional testing after non-diagnostic stress echocardiography in patients presenting with chest pain: A single-center analysis JAm Coll Cardiol 2016; 67(13):520. PMID: Not assigned. Abstract

Gupta RC, Sing-Gupta V, Palaniyandi S, and Sabbah HN. Reduced aldehyde dehydrogenase-2 activity and protein level in left ventricular myocardium of dogs with chronic heart failure J Am Coll

146 Cardiol 2016; 67(13):1498. PMID: Not assigned. Abstract

Gupta RC, Sing-Gupta V, and Sabbah HN. Bendavia (elamipretide) restores phosphorylation of cardiac myosin binding protein c on serine 282 and improves left ventricular diastolic function in dogs with heart failure J Am Coll Cardiol 2016; 67(13):1443. PMID: Not assigned. Abstract

Hachey B, Kontos M, Newby LK, Peacock WF, and McCord J. Trends in cardiac biomarker protocols and troponin cut-points J Am Coll Cardiol 2016; 67(13):467. PMID: Not assigned. Abstract

Jain T, Nowak R, Hudson M, Frisoli T, Jacobsen G, Tabaku M, and McCord J. Short and long- term prognostic utility of the heart score in patients presenting to the emergency department with undifferentiated chest pain JAm Coll Cardiol 2016; 67(13):513. PMID: Not assigned. Abstract

Karacsonyi J, Alaswad K, Jaffer F, Yeh R, Patel M, Bahadorani J, Danek BA, Karatasakis A, Doing A, Grantham JA, Karmpaliotis D, Moses J, Kirtane A, Parikh M, Ali Z, Lombardi W, Kandzari D, Lembo N, Garcia S, Wyman RM, Alame A, Martinez-Parachini JR, Nguyen-Trong PK, Resendes E, Kalsaria P, Rangan B, Ungi I, Thompson C, Banerjee S, and Brilakis E. TCT-572 Use of intravascular imaging during chronic total occlusion percutaneous coronary intervention: Insights from a contemporary multicenter registry J Am Coll Cardiol 2016; 68(18s):B231. PMID: 27969943. Abstract

Karatasakis A, Danek BA, Karmpaliotis D, Alaswad K, Jaffer F, Yeh R, Patel M, Bahadorani J, Lombardi W, Wyman RM, Grantham JA, Kandzari D, Lembo N, Doing A, Toma C, Moses J, Kirtane A, Parikh M, Ali Z, Garcia S, Kalsaria P, Karacsonyi J, Alame A, Thompson C, Banerjee S, and Brilakis E. TCT-289 Comparison of various scores for predicting success and efficiency of chronic total occlusion percutaneous coronary intervention J Am Coll Cardiol 2016; 68(18s):B119. PMID: 27969631. Abstract

Karatasakis A, Danek BA, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh R, Kandzari D, Lembo N, Patel M, Bahadorani J, Lombardi W, Wyman RM, Grantham JA, Doing A, Toma C, Choi J, Uretsky B, Garcia S, Moses J, Kirtane A, Ali Z, Parikh M, Karacsonyi J, Rangan B, Thompson C, Banerjee S, and Brilakis E. TCT-278 Application and outcomes of the hybrid approach to chronic total occlusion percutaneous coronary intervention: An update from a contemporary multicenter us registry J Am Coll Cardiol 2016; 68(18s):B113-b114. PMID: 27969620. Abstract

Khan J, Rogers T, Faranesh A, Greenbaum A, Babaliaros V, Chen M, and Lederman R. Tct-642 intentional laceration of the anterior mitral valve leaflet to prevent left ventricular outflow tract obstruction (lampoon) during transcatheter mitral valve implantation: Preclinical findings J Am Coll Cardiol 2016; 68(18s):B261. PMID: 27970020. Abstract

Kupsky D, Wang DD, Eng M, Song T, Pantelic M, Nadig J, Greenbaum A, and O'Neill W. TCT- 621 Left atrial appendage characteristics evaluated by computed tomography following closure with Watchman device J Am Coll Cardiol 2016; 68(18s):B253. PMID: 27969997. Abstract

Lanfear DE, Levy WC, Stehlik J, Estep JD, Rogers JG, Shah KB, Boyle AJ, Chuang J, Farrar DJ, and Starling RC. Accuracy of seattle heart failure model and heartmate II risk score in non-inotrope dependent advanced heart failure patients: Insights from the roadmap study J Heart Lung Transplant 2016; 35(4):S109. PMID: Not assigned. Abstract

Luo N, Merrill P, Whellan DJ, Pina IL, Fiuzat M, Kraus WE, Kitzman DW, Keteyian SJ, O'Connor CM, and Mentz RJ. Exercise training in patients with chronic heart failure and atrial fibrillation: Results from the hf-action trial J Card Fail 2016; 22(8):S71-S71. PMID: Not assigned. Abstract

Maini B, Moses J, Dixon S, Anderson M, Lombardi W, Moller JE, Henriques J, Schafer A, Schreiber T, Ohman EM, and O'Neill W. TCT-24 Global cVAD Registry: A global initiative in percutaneous circulatory support From the cVAD Steering Committee on behalf of all cVAD Investigators J Am Coll Cardiol 2016; 68(18s):B10. PMID: 27969582. Abstract

Mawri S, Alsafadi MY, Jain T, Al-Darzi W, Shah J, Michaels A, Gibbs J, Dirani G, Albashaireh D, and Ananthasubramaniam K. Diastolic dysfunction in septic shock: Insights from echocardiography Chest 2016; 150(4):355A. PMID: Not assigned. Abstract 147 McIlvennan CK, Bryce K, Lindenfeld J, Allen LA, and Lanfear DE. Assessment of cognitive function prior to and after implantation of left ventricular assist device J Heart Lung Transplant 2016; 35(4):S165-S166. PMID: Not assigned Abstract

Michaels AT, Radjef R, She RC, Liu B, Peterson E, Pinto Y, Williams K, Sabbah H, and Lanfear D. Improving risk prediction in heart failure: MAGGIC plus natriuretic peptides J Card Fail 2016; 22(8):S99- S99. PMID: Not assigned. Abstract

Michaels AT, Radjef R, She R, Peterson E, Liu B, and Lanfear DE. Predicting mortality at discharge following hospitalization for acute heart failure J Card Fail 2016; 22:S21-S22. PMID: Not assigned. Abstract

Muller CC, McCord J, Michaels A, Nowak R, Giannitsis E, Body R, Christ M, Lindahl B, DeFilippi C, Christenson R, Bendig G, Jacobsen G, and Mueller C. Symptoms predictive of acute myocardial infarction in the troponin era: Analysis from the TRAPID-AMI study J Am Coll Cardiol 2016; 67(13):518. PMID: Not assigned. Abstract

Nakagawa P, Xu J, Bordcoch G, Janic B, and Carretero OA. Inhibition of neutrophil chemotaxis by N-acetyl-seryl- aspartyl-lysyl-proline and thymosin β4 FASEB Journal 2016; 30PMID: Not assigned. Abstract

Radjef R, Michaels A, Peterson E, She R, Liu B, Williams K, Sabbah H, and Lanfear D. Performance of MAGGIC score in african americans compared to whites J Card Fail 2016; 22(8):S101- S101. PMID: Not assigned. Abstract

Raymond T, Mawri S, Jacobsen G, Selektor Y, Velez M, Williams C, Nemeh H, Borgi J, Morgan J, Lanfear D, and Tita C. The incidence of spontaneous intracranial hemorrhage is associated with infection in patients with mechanical circulatory support J Heart Lung Transplant 2016; 35(4):S246. PMID: Not assigned. Abstract

Resendes E, Karmpaliotis D, Alaswad K, Jaffer F, Yeh R, Wyman RM, Patel M, Bahadorani J, Lombardi W, Grantham JA, Kandzari D, Lembo N, Moses J, Kirtane A, Toma C, Doing A, Choi J, Uretsky B, Alame A, Karacsonyi J, Danek BA, Smith M, Karatasakis A, Rangan B, Banerjee S, and Brilakis E. TCT-308 Impact of race and ethnicity on technical and in-hospital outcomes following chronic total occlusions percutaneous coronary intervention J Am Coll Cardiol 2016; 68(18s):B126- b127. PMID: 27969651. Abstract

Rezik M, and Mattina D. Severe cardiomyopathy secondary to anti-TNF therapy for crohn's disease J Am Coll Cardiol 2016; 67(13):1042. PMID: Not assigned. Abstract

Sabbah HN, Gupta RC, and Emanuele M. Vepoloxamer (purified sodium-free poloxamer-188) improves LV systolic function in dogs with advanced heart failure and protects failing cardiomyocytes from calcium overload J Heart Lung Transplant 2016; 35(4):S141. PMID: Not assigned. Abstract

Sabbah HN, Gupta RC, Sing-Gupta V, Zhang K, and Emanuele M. Multiple intravenous infusions of vepoloxamer (purified poloxamer-188) elicit progressive improvements in plasma biomarkers in dogs with advanced heart failure J Am Coll Cardiol 2016; 67(13):1551. PMID: Not assigned. Abstract

Sabbah HN, Gupta RC, Sing-Gupta V, Zhang K, and Emanuele M. Vepoloxamer (purified poloxamer- 188) restores integrity of cardiomyocyte calcium cycling proteins in left ventricular myocardium of dogs with advanced heart failure J Am Coll Cardiol 2016; 67(13):1449. PMID: Not assigned. Abstract

Sabbah HN, Gupta RC, and Sing-Gupta V. Circulating blood levels of growth differentiation factor 11 are decreased in dogs with heart failure and restored after long-term therapy with elamipretide (Bendavia, MTP-131) Eur J Heart Fail 2016; 18:424. PMID: Not assigned. Abstract

Sabbah HN, Gupta RC, Sing-Gupta V, and Zhang K. Elamipretide (Bendavia, MTP-131) normalizes cGMP levels in left ventricular myocardium of dogs with advanced heart failure Eur J Heart Fail 2016; 18:296. PMID: Not assigned. Abstract

148 Sabbah HN, Gupta RC, Gupta V, and Emanuele M. Vepoloxamer (purified poloxamer-188) improves LV function, limits cardiomyocyte calcium overload and restores integrity of calciu cycling proteins in myocardium of dogs with advanced heart failure European Journal of Heart Failure 2016; 18:9. PMID: Not assingned. Abstract

Sabbah HN, Gupta RC, Sing-Gupta V, Zhang K, and Xu J. Long-term therapy with elamipretide normalizes ATP synthase activity in left ventricular myocardium of dogs with advanced heart failure J Card Fail 2016; 22:S23. PMID: Not assigned. Abstract

Sareen N, Mariychina A, Hector C, Mahan M, and Ananthasubramaniam K. Do right ventricular diastolic tissue doppler parameters add diagnostic value in pulmonary hypertension? J Am Soc Echocardiogr 2016; 29(6):B101. PMID: Not assigned. Abstract

Sengupta R, Aljasmi M, Jain T, and Hegab S. Presentation of sub-massive pulmonary embolism mimicking acute liver failure Chest 2016; 150(4):429A. PMID: Not assigned. Abstract

Shah R, Singh G, Lahiri M, Patel R, and Schuger C. Central nervous system mediated cardiac asystole in setting of paraneoplastic N-methyl-D-aspartate receptor antibody encephalitis J Am Coll Cardiol 2016; 67(13):1253. PMID: Not assigned. Abstract

Sharma S, Palacios I, O'Neill W, and Witzke CF. Tct-124 predictors of the need for continuous impella support in high risk percutaneous coronary intervention J Am Coll Cardiol 2016; 68(18s):B50. PMID: 27970289. Abstract

Shavelle D, Kapasi N, Banerjee S, Schreiber T, O'Neill W, Popma J, and Matthews R. Tct-127 prior coronary artery bypass graft surgery and hemodynamically supported high risk percutaneous coronary intervention: Observations from the protect ii randomized trial and the cvad registry J Am Coll Cardiol 2016; 68(18s):B51. PMID: 27970292. Abstract

Singh V, Rodriguez A, Bhatt P, Thakkar B, Patel N, Cohen M, Palacios I, Inglessis I, Elmariah S, and O'Neill W. TCT- 151 ventricular septal rupture complicating st-elevation myocardical infarctions: A nationwide analysis J Am Coll Cardiol 2016; 68(18s):B62. PMID: 27970321. Abstract

Singh V, Thakkar B, Rodriguez A, Patel N, Badheka A, Alfonso C, Cohen M, Palacios I, Inglessis I, Elmariah S, and O'Neill W. TCT-697 comparison of outcomes of transcatheter aortic valve replacement plus percutaneous coronary intervention versus transcatheter aortic valve replacement alone in the united states J Am Coll Cardiol 2016; 68(18s):B282. PMID: 27970079. Abstract

Small B, Mitchell G, Hrabec D, Selim R, and Wang DD. Hyperandrogenism and spontaneous coronary artery dissection: A new entity? Chest 2016; 150(4):89A. PMID: Not assigned. Abstract

Toma C, Karatasakis A, Karmpaliotis D, Alaswad K, Yeh R, Jaffer F, Kandzari D, Lembo N, Lombardi W, Grantham JA, Wyman RM, Doing A, Patel M, Bahadorani J, Moses J, Kirtane A, Ali Z, Danek BA, Karacsonyi J, Rangan B, Banerjee S, and Brilakis E. TCT-273 Predictors of successful Stingray- assisted antegrade dissection reentry: data from the Progress CTO registry J Am Coll Cardiol 2016; 68(18s):B111-b112. PMID: 27969614. Abstract

Wang DD, Eng M, Myers E, Forbes M, Karabon P, Greenbaum A, and O'Neill W. Inferior and posterior: Utilization of 3D print and computer aided design to spatially map optimal transseptal crossing point for left atrial appendage occlusion with the watchman device J Am Coll Cardiol 2016; 67(13):323. PMID: Not assigned. Abstract

Wang DD, Eng M, Greenbaum A, Guerrero M, and O'Neill W. TCT-626 Validating a prediction modeling tool for LVOT obstruction after transcatheter mitral valve replacement J Am Coll Cardiol 2016; 68(18s):B254-b255. PMID: 27970000. Abstract

Xuereb L, Kaur B, Akrawe S, Nemeh HW, Borgi J, Lanfear DE, Williams CT, Paone G, and Morgan JA. Does preoperative atrial fibrillation increase the incidence of thromboembolic complications in patients supported with long- term LVADs? J Heart Lung Transplant 2016; 35(4):S130-S131. PMID: 149 Not assigned. Abstract

Xuereb L, Kaur B, Akrawe S, Rashty J, Nemeh HW, Borgi J, Lanfear DE, Williams CT, Paone G, and Morgan JA. Reoperation for bleeding does not adversely impact long-term outcomes in LVAD recipients J Heart Lung Transplant 2016; 35(4):S249. PMID: Not assigned. Abstract

Xuereb L, Kaur B, Akrawe S, Rashty J, Nemeh HW, Borgi J, Tita C, Selektor Y, Velez M, Lanfear DE, Williams CT, Paone G, and Morgan JA. Drive line infections are not associated with an increased incidence of thromboembolic complications in patients on continuous flow LVAD support J Heart Lung Transplant 2016; 35(4):S246. PMID: Not assigned. Abstract

Yadav P, Eng M, Divine G, Wang DD, Arjomand-Fard H, Wyman J, Isley M, Borgi J, Paone G, Greenbaum A, and O'Neill W. Outcomes of impella assisted percutaneous balloon aortic valvuloplasty in very high risk severe aortic stenosis patients J Am Coll Cardiol 2016; 67(13):404. PMID: Not assigned. Abstract

Yadav P, Singh V, Eng M, MacEdo F, Silva G, Rassi A, Mendirichaga R, Alfonso C, Cohen M, Palacios I, and O'Neill W. TCT-136 outcomes of hemodynamic support with impella in very high-risk patients undergoing balloon aortic aortic valvuloplasty: Results from the global cvad registry J Am Coll Cardiol 2016; 68(18s):B55. PMID: 27970300. Abstract

Yadav P, Wang DD, Eng M, Greenbaum A, and O'Neill W. Tct-813 alcohol septal ablation in patients with left ventricular outflow tract obstruction after transcatheter mitral valve replacement for mitral annular calcification (TMVR in MAC) J Am Coll Cardiol 2016; 68(18s):B329. PMID: 27970202. Abstract

Zhu L, Xu J, Harding P, and Yang XP. Role of ACE2 in the cardioprotective effects of angiotensin II type 2 receptors FASEB Journal 2016; 30PMID: Not assigned. Abstract

150 Endocrinology and Metabolism

Honasoge M. Immobilization hypercalcemia in a patient with erdheim-chester disease with skeletal lesions and end stage renal disease: Response to intravenous zolendronic acid Endocrine Reviews 2016; 37(2)PMID: Not assigned. Abstract

Honasoge M. Refractory amiodarone induced thyrotoxicosis: Management challenges, use of cholestyramine and surgery Endocrine Reviews 2016; 37(2)PMID: Not assigned. Abstract

Honasoge M. Reversible thyrotoxic cardiomyopathy and cardiogenic shock in a young woman with painless thyroiditis:Is thyrotoxic cardiomyopathy a form of takotsubo cardiomyopathy? Endocrine Reviews 2016; 37(2)PMID: Not assigned. Abstract

151 Gastroenterology

Agrawal S, Hussain S, Elbatta M, Markus J, Jafri SM, and Ibrahim M. Adenomyomatous polyp of the duodenum: A phenomenon seen rarely Am J Gastroenterol 2016; 111:S987. PMID: Not assigned. Abstract

Agrawal S, Mullins K, Tosch K, Muszkat Y, and Jafri SM. Single-center experience in concurrent use of ombitasvir/paritaprevir/ritonavir with dasabuvir and tacrolimus for recurrent hepatitis C after liver transplantation Am J Gastroenterol 2016; 111:S907-S908. PMID: Not assigned. Abstract

Aguin V, Bhatti F, El Atrache M, and Kaur N. An unusual case of polypoid vascular ectasia Am J Gastroenterol 2016; 111:S732-S733. PMID: Not assigned. Abstract

Aguin V, Meighani A, Hussain S, Atrache ME, Elbatta M, Bukannan A, Jafri SM, and Ibrahim M. Elevated head of the bed, a novel position for performing colonoscopy: Does it improve the quality of the examination? Am J Gastroenterol 2016; 111:S141. PMID: Not assigned. Abstract

Ahmed A, Saab S, Gordon SC, Dieterich DT, Wong RJ, Brown KA, Kugelmas M, and Younossi ZM. A decision analytic markov model to evaluate the health outcomes of sofosbuvir/velpatasvir for patients with chronic hepatitis C virus genotypes 1 to 6 and decompensated cirrhosis in the US Hepatology 2016; 63(1):418A. PMID: Not assigned. Abstract

Alali F. A rare case of pneumatosis intestinalis Am J Gastroenterol 2016; 111:S1366. PMID: Not assigned. Abstract

Bourlière M, Gordon SC, Ramji A, Ravendhran N, Tran TT, Hyland RH, Zhang J, Dvory-Sobol H, Stamm LM, Brainard DM, Subramanian M, McHutchison JG, Younes Z, Curry MP, Schiff ER, Reddy KR, and Manns MP. Sofosbuvir/velpatasvir/voxilaprevir for 12 weeks as a salvage regimen in NS5A inhibitor-experienced patients with genotype 1-6 infection: The phase 3 POLARIS-1 study Hepatology 2016; 63(1):102A-103A. PMID: Not assigned. Abstract

Brown P, Parekh R, and Zalawadia A. A rare case of abdominal tuberculosis Am J Gastroenterol 2016; 111:S1032- S1033. PMID: Not assigned. Abstract

Chhatwal J, Chen Q, Ayer T, Kanwal F, Kowdley KV, Wang X, Roberts MS, and Gordon SC. Patients who fail treatment in the era of DAAs: Projections from HEP-SIM Model Hepatology 2016; 63(1):412A. PMID: Not assigned. Abstract

Gane EJ, Nguyen M, Kwo P, Kowdley K, Reau N, Jacobson I, Curry M, Pearlman B, Khalid O, Everson G, Gordon S, Poulos J, Sheikh A, Bernstein D, Yang JC, Stamm LM, An D, Dvory-Sobol H, Brainard DM, McHutchison JG, Tong M, Tsai N, Beavers KL, Rabinovitz M, Shiffman M, Stedman C, and Lawitz E. Short duration treatment with sofosbuvir/velpatasvir plus GS-9857 in treatment-naive genotype 1-6 HCV-infected patients with or without cirrhosis J Hepatol 2016; 64(2):S758-S759. PMID: Not assigned. Abstract

Gill B, Soman S, and Bhan A. Comparison of the glasgow-blatchford risk score vs aims65 score in patients on coumadin and anti-platelet therapy or dual anti-platelet therapy Am J Gastroenterol 2016; 111:S494-S495. PMID: Not assigned. Abstract

Gordon SC, Ahmed A, Kugelmas M, Dieterich DT, Wong R, Brown KA, Saab S, and Younossi ZM. A Decision analytic markov model to evaluate the health outcomes of sofosbuvir/velpatasvir for patients with chronic hepatitis C virus genotype 2 and 3 infection in the US Hepatology 2016; 63(1):422A-423A. PMID: Not assigned. Abstract

Hart BR, El Atrache M, and Zalawadia A. A rare case of simultaneous metastatic disease of renal cell carcinoma to the stomach, bone, and lungs Am J Gastroenterol 2016; 111:S1143-S1144. PMID: Not assigned. Abstract

Hart BR, Sedki M, Bukannan A, Zalawadia A, Blumenkehl M, and Jafri SM. Retrospective analysis of specific vs non-specific beta blockers for variceal bleed Am J Gastroenterol 2016; 152 111:S1262-S1264. PMID: Not assigned. Abstract

Jesse M, Goldstein E, Macaulay T, Rebhan N, Ho CX, Bebanic M, Shkokani L, Abouljoud M, Eshelman A, and Yoshida A. Racial disparities in cognitive and social requirements prior to listing for liver transplant Am J Transplant 2016; 16:517. PMID: Not assigned. Abstract

Jesse M, Goldstein E, Rebhan N, Ho CX, Macaulay T, Bebanic M, Shkokani L, Moonka D, Abouljoud M, and Yoshida A. Racial disparities in the evaluation for liver transplantation Am J Transplant 2016; 16:520-521. PMID: Not assigned. Abstract

Lee-Allen J, Hussain S, Jones D, Jafri SM, and Siddiqui Y. Meckel's diverticulum; an obscure cause of adult gastrointestinal bleed Am J Gastroenterol 2016; 111:S1371. PMID: Not assigned. Abstract

Lenhart A, Folt D, Markus J, Cerasale M, and Moonka D. A rare case of a sex cord stromal tumor presenting as elevated liver function tests Am J Gastroenterol 2016; 111:S864-S865. PMID: Not assigned. Abstract

Lenhart A, Hassan M, Meighani A, Sadiq O, and Siddiqui Y. A perplexing case of abdominal pain that led to the diagnosis of zollinger-ellison syndrome Am J Gastroenterol 2016; 111:S1056. PMID: Not assigned. Abstract

Li J, Gordon S, Rupp L, Zhang T, Boscarino J, Trinacty C, Schmidt M, Moorman A, Holmberg S, and Lu M. Long- term fibrosis and viral level progression among treated and untreated patients with chronic hepatitis B J Hepatol 2016; 64(2):S371. PMID: Not assigned. Abstract

Lu M, Gordon SC, Li J, Rupp LB, Zhou Y, Moorman AC, Spradling P, Teshale EH, Boscarino JA, Daida Y, Schmidt MA, Trudeau S, and Holmberg SD. Hepatitis C complications: Prevalence and disparities in a large US cohort 2006- 2014 Hepatology 2016; 63(1):95A-96A. PMID: Not assigned. Abstract

Lu M, Li J, Rupp LB, Boscarino JA, Raebel M, Schmidt MA, Haller IV, Daida Y, Rodriguez CV, Sahota A, VanWormer JJ, Romanelli RG, Vincent J, and Gordon SC. Prevalence of primary biliary cholangitis (PBC) in large US health care systems: Case ascertainment using electronic health records Hepatology 2016; 63(1):196A. PMID: Not assigned. Abstract

Meighani A, Hassan M, Lenhart A, and Gordon S. Aortitis in a patient with chronic hepatitis C virus infection Am J Gastroenterol 2016; 111:S870-S871. PMID: Not assigned. Abstract

Meighani A, Ramesh M, and Salgia R. Successful outcomes of fecal microbiota transplantation in patients with chronic liver disease Hepatology 2016; 63(1):1016A-1017A. PMID: Not assigned. Abstract

Meighani A, Rao B, Hassan M, Abboud R, and Pompa R. Does presenting with an acute diverticular bleed prior to the weekend result in a longer wait time to colonoscopy? Am J Gastroenterol 2016; 111:S1227-S1228. PMID: Not assigned. Abstract

Moonka D, Nagai S, Divine G, and Salgia R. Influence of donor age and cold ischemia on recurrence of hepatocellular carcinoma after liver transplantation Transplantation 2016; 100(7):S427. PMID: Not assigned. Abstract

Moonka D, Nagai S, Gadde R, Datta L, Divine G, Abouljoud MS, and Salgia R. Effect of tumor necrosis from loco- regional therapy prior to liver transplantation on hepatocellular carcinoma recurrence after transplant Hepatology 2016; 63(1):640A-641A. PMID: Not assigned. Abstract

Moonka D, Shah V, Datta L, Gadde R, Divine G, Yoshida A, Jafri SM, and Salgia R. Degree of tumor necrosis from pre-transplant loco-regional therapy is associated with tumor free survival after liver transplantation Transplantation 2016; 100(7):S429. PMID: Not assigned. Abstract O'Leary JG, Brown K, Burton Jr J, Firpi-Morell R, Fontana RJ, Muir A, O'Brien C, Rabinovitz M, 153 Rajender Reddy K, Ryan R, Shprecher A, Villadiego S, Prabhakar A, and Brown Jr RS. Efficacy and safety of simeprevir and sofosbuvir with and without ribavirin for 12 weeks in subjects with recurrent genotype 1 hepatitis C post-orthotopic liver transplant: The galaxy study Journal of Hepatology 2016; 64(2):S540. PMID: Not assigned. Abstract

Parekh R, Segovia M, and Kaur N. Tumor-necrosis-factor-α antagonist therapy for inflammatory bowel disease after liver transplantation Am J Transplant 2016; 16:666-667. PMID: Not assigned. Abstract Parekh R, Ramesh MS, and Tang J. Lymphocytic colitis in patients with recurrent clostridium difficile colitis: Case series Am J Gastroenterol 2016; 111:S1308. PMID: Not assigned. Abstract

Poordad F, Gordon SC, Asatryan A, Felizarta F, Reindollar RW, Landis C, Fried MW, Bernstein DE, Ng TI, Lin CW, Liu R, Kort J, and Mensa FJ. High efficacy of ABT-493 and ABT-530 in HCV genotype 1 infected patients who have failed direct-acting antiviral-containing regimens: The Magellan-i study J Hepatol 2016; 64(2):S160-S161. PMID: Not assigned. Abstract

Ramesh MS, Khanna S, Messer J, and Adams M. Durable prevention of recurrent C. Difficile infection with RBX2660: Results of the PUNCH CD 2 trial Am J Gastroenterol 2016; 111:S93. PMID: Not assigned. Abstract

Rao B, Yoshida A, Ibrahim M, and Jafri SM. The use of perioperative lactate values as markers for adverse outcomes in liver transplantation Am J Transplant 2016; 16:672. PMID: Not assigned. Abstract

Rao B, Markus J, Bukannan A, Parekh R, and Moonka D. Acute pulmonary embolism masquerading as acute liver failure Am J Gastroenterol 2016; 111:S946. PMID: Not assigned. Abstract

Rebhan N, Bebanic M, Yoshida A, Macaulay T, Goldstein E, Ho CX, Eshelman A, Abouljoud M, Jesse M, and Rizzari M. Psychiatric characteristics of acute liver failure patients: Acetaminophen overdose versus other etiologies Am J Transplant 2016; 16:524. PMID: Not assigned. Abstract

Roberts SK, Mangia A, Pianko S, Thompson AJ, Cooper C, Conway B, Bourlière M, Asselah T, Berg T, Zeuzem S, Rosenberg WM, Agarwal K, Gane EJ, Stedman CA, Mazzotta F, Tran TT, Gordon SC, Brainard DM, Afdhal NH, and Foster GR. Sofosbuvir/velpatasvir for 12 wks vs sofosbuvir + ribavirin for 24 wks in GT3 HCV: The ASTRAL-3 study Hepatol Int 2016; 10(1):S11-S12. PMID: Not assigned. Abstract

Siddiqui MA, Eraqi H, Omar S, and Jafri SM. Massive disparity in insurance approval; a comparison between ledipasvir/sofosbuvir based hepatitis C therapy and adalimumab based IBD therapy Hepatology 2016; 63(1):474A. PMID: Not assigned. Abstract

Siddiqui MA, Iraqi H, Aggarwal R, Varma A, El Atrache M, and Jafri SM. Insurance approval rates for medicaid patients: A comparison between ledipasvir/sofosbuvir based hepatitis C therapy and adalimumab based IBD therapy Am J Gastroenterol 2016; 111:S365. PMID: Not assigned. Abstract

Siddiqui MA, Tang J, Khan S, El Atrache M, Varma A, Aggarwal R, and Jafri SM. A case of necrotising pancreatitis following ampullary biopsy Am J Gastroenterol 2016; 111:S549-S550. PMID: Not assigned. Abstract

Souther B, Arnautovic J, and Singh G. Ischemic colitis complicated by consumptive coagulopathy Am J Gastroenterol 2016; 111:S1306-S1307. PMID: Not assigned. Abstract

Spradling PR, Xing J, Rupp LB, Moorman AC, Gordon SC, Lu M, Teshale EH, Boscarino JA, Daida Y, Schmidt MA, and Holmberg SD. Uptake of and factors associated with direct-acting antiviral therapy among patients infected with hepatitis C virus in the chronic hepatitis cohort study, 2014-2015 Hepatology 2016; 63(1):10A-11A. PMID: Not assigned. Abstract

Spradling PR, Xing J, Rupp LB, Moorman AC, Gordon SC, Lu M, Teshale EH, Boscarino JA, Daida Y, Schmidt MA, and Holmberg SD. Preliminary clinical outcome data among patients with hepatitis C virus infection receiving direct- acting antiviral therapy in the Chronic Hepatitis Cohort Study, 2014- 154 2015 Hepatology 2016; 63(1):487A-488A. PMID: Not assigned. Abstract

Teshale EH, Zhong Y, Moorman AC, Spradling PR, Holmberg SD, Rupp LB, Lu M, Gordon SC, Boscarino JA, Daida Y, and Schmidt MA. Alcohol use disorder among chronic hepatitis C patients: Prevalence and treatment outcome, CHeCS, 2006-2013 Hepatology 2016; 63(1):873A-874A. PMID: Not assigned. Abstract

Verna E, Levitsky J, O'Leary J, Bzowej N, Moonka D, Hyland R, Brainard D, McHutchison J, and Terrault N. Short duration perioperative administration of ledipasvir/sofosbuvir is safe and effective in preventing HCV recurrence after liver transplant Am J Transplant 2016; 16:333-334. PMID: Not assigned. Abstract

Weick A, Sadiq O, Jafri SM, and Moonka D. Initial experience with ledipasvir-sofosbuvir based therapy for recurrent hepatitis C after liver transplantation Am J Transplant 2016; 16:793. PMID: Not assigned. Abstract

Weick A, and Lee A. Statin-induced liver injury mimicking autoimmune hepatitis Am J Gastroenterol 2016; 111:S864. PMID: Not assigned. Abstract

155

Hematology-Oncology

Aljundi L, Miller N, Taylor A, Hung J, and Hwang C. Time to castration-resistance and docetaxel outcomes in metastatic prostate cancer J Clin Oncol 2016; 34PMID: Not assigned. Abstract

Ali HY, Munir K, Braun T, Griggs JJ, Silver SM, Gorski DH, Breslin TM, and Henry NL. Appropriate use of the 21- gene recurrence score (RS) assay across Michigan Cancer Research 2016; 76(4)PMID: Not assigned. Abstract

Apolo AB, Infante JR, Hamid O, Patel MR, Wang D, Kelly K, Mega AE, Britten CD, Mita AC, Ravaud A, Cuillerot JM, von Heydebreck A, and Gulley JL. Safety, clinical activity, and PD-L1 expression of avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with metastatic urothelial carcinoma from the JAVELIN Solid Tumor phase Ib trial J Clin Oncol 2016; 34(2) PMID: Not assigned. Abstract

Apolo AB, Infante JR, Hamid O, Patel MR, Wang D, Kelly K, Mega AE, Britten CD, Ravaud A, Mita AC, Safran H, Stinchcombe T, Grote HJ, V on Heydebreck A, Cuillerot JM, and Gulley JL. Avelumab (MSB0010718C; anti-PD-L1) in patients with metastatic urothelial carcinoma from the JAVELIN solid tumor phase 1b trial: Analysis of safety, clinical activity, and PD-L1 expression J Clin Oncol 2016; 34PMID: Not assigned. Abstract

Bardia A, Dacosta NA, Gabrail NY, Lemon S, Danso MA, Ali HY, Fleming RA, Kurman MR, Eisner JR, Moore WR, Gucalp A, and Traina TA. Phase (Ph) 1 study of oral seviteronel (VT-464), a dual CYP17- Lyase (L) inhibitor and androgen receptor (AR) antagonist, in patients (pts) with advanced AR+ triple negative (TNBC) or estrogen receptor (ER)+ breast cancer (BC) J Clin Oncol 2016; 34PMID: Not assigned. Abstract

Bauer MT, Adkins D, Schwartz GK, Werner TL, Alva AS, Hong DS, Carvajal RD, Saleh MN, Bazhenova L, Goel S, Eaton KD, Siegel RD, Wang D, Lauer RC, Neuteboom STC, Faltaos D, Chen I, Christensen J, Chao RC, and Heist RS. A first in human phase I study of receptor tyrosine kinase (RTK) inhibitor MGCD516 in patients with advanced solid tumors J Clin Oncol 2016; 34PMID: Not assigned. Abstract

Berdeja JG, Heinrich M, Dakhil S, Goldberg SL, Wadleigh M, Catchatourian R, Kuriakose P, Cortes JE, Radich JP, Rizzieri DA, Bonifacio G, Dautaj I, Warsi G, and Mauro MJ. ENESTnext final results: Deep molecular response (MR) with nilotinib (NIL) in patients (pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) Blood 2015; 126(23):4. PMID: Not assigned. Abstract

Cristea MC, Miao J, Argiris A, Chen AM, Daly ME, Decker RH, Garland LL, Wang D, Koczywas M, Moon J, Kelly K, and Gandara DR. SWOG S1206: A dose-finding study of veliparib (ABT-888) added to chemoradiotherapy (CRT) with carboplatin (C) and paclitaxel (P) for unresectable stage III non-small cell lung cancer (NSCLC) J Clin Oncol 2016; 34PMID: Not assigned. Abstract

Farhan S, Peres E, and Janakiraman N. Cytomegalovirus and effect on early chimerism in patients with myeloid disorders undergoing stem cell transplantation using reduced toxicity ablative conditioning regimen Bone Marrow Transplant 2016; 51:S328. PMID: Not assigned. Abstract

Farhan S, Pelland D, Wautelet S, Neme K, Mikulandric N, Trapp MA, Szymanski S, Ruemenapp K, Peres E, and Janakiraman N. Impact of cytomegalovirus on early chimerism in patients with myeloid disorders undergoing stem cell transplantation using reduced toxicity ablative conditioning regimen Biol Blood Marrow Transplant 2016; 22(3):S318-S318. PMID: Not assigned. Abstract

Farhan SY, Divine G, Neme K, Pelland D, Wautelet S, Mikulandric N, Ruemenapp K, Peres E, and Janakiraman N. Cytomegalovirus and effect on early chimerism in patients with myeloid disorders undergoing stem cell transplantation using reduced toxicity ablative conditioning regimen Blood 2015; 126(23):3. PMID: Not assigned. Abstract

Gajra A, Ali H, Amiri KI, Karim NA, Matrana MR, Mulford D, Ong TJ, Sanford A, Santos ES, Socinski MA, and Spigel DR. Ps01.08: Abound.Ps2 interim safety results: Nab-paclitaxel/carboplatin followed 156 by nab-paclitaxel in nsclc patients with ecog ps of 2: Topic: Medical oncology J Thorac Oncol 2016; 11(11s):S274. PMID: 27969477. Abstract

Geary M, Kachalsky E, Pennick L, Johnson M, Hatcher N, Rosenblatt K, Dunn L, and Stolfi A. Perceived ideal roles of hemophilia treatment center social workers in the United States and barriers to those roles Haemophilia 2016; 22:113-113. PMID: Not assigned. Abstract

Geary M, Kachalsky E, Pennick L, Rosenblatt K, Hatcher N, Johnson M, Dunn L, and Stolfi A. Social work caseloads in hemophilia treatment centers in the United States Haemophilia 2016; 22:117-117. PMID: Not assigned. Abstract

Hamel LM, Eggly S, Penner L, Chapman R, Frank J, Klamerus A, and Albrecht TL. Patient and oncologist discussions of treatment costs J Clin Oncol 2016; 34(7s):1. PMID: Not assigned. Abstract

Harvey RD, Gore L, Wang D, Mita A, Sharma S, Nemunaitis J, Papadopoulos K, Pinchasik D, Ou Y, Demirhan E, Cutler RE, and Tsimberidou AM. A phase I study to assess food effect on oprozomib in patients with advanced malignancies Clin Pharmacol Ther 2016; 99:S98-S99. PMID: Not assigned. Abstract

Henry NL, Ali H, Braun T, Munir K, Silver SM, Griggs JJ, Breslin TM, and Gorski DH. Use across Michigan of the 21- gene recurrence score (RS) assay in lymph node positive patients with breast cancer Cancer Research 2016; 76(4)PMID: Not assigned. Abstract

Henry NL, Braun T, Lusk E, Munir K, Griggs JJ, Gorski DH, Silver SM, Breslin TM, and Ali HY. Variation in use of advanced imaging at the time of breast cancer diagnosis in a statewide registry J Clin Oncol 2016; 34(7)PMID: Not assigned. Abstract

Jiang F, Cabrera Fernandez DF, Church J, Gulati R, Taylor A, Menon M, and Kuriakose P. Correlation between peripheral blood counts and day 14 bone marrow biopsy in acute myeloid leukemia during induction chemotherapy Blood 2015; 126(23):3. PMID: Not assigned. Abstract

Johnson M, Kachalsky E, Geary M, Pennick L, Dunn L, Hatcher N, Stolfi A, and Rosenblatt K. The role of the Hemophilia Treatment Center (HTC) social worker in the United States Haemophilia 2016; 22:117-117. PMID: Not assigned. Abstract

Kelly K, Heery CR, Patel MR, Infante JR, Iannotti N, Leach JW, Wang D, Chandler JC, Arkenau HT, Taylor MH, Gordon MS, Wong DJL, Safran H, Kaufman H, Keilholz U, Bajars M, V on Heydebreck A, Speit I, Cuillerot JM, and Gulley JL. Avelumab (MSB0010718C; anti-PD-LI) in patients with advanced cancer: Safety data from 1300 patients enrolled in the phase 1b JAVELIN Solid Tumor trial J Clin Oncol 2016; 34PMID: Not assigned. Abstract

Kuriakose J, John J, Hanagavadi S, Balar M, Pillai V, and Kuriakose P. Impact of twinning between HTC's: Incremental gain with longitudinal experience Haemophilia 2016; 22:54-54. PMID: Not assigned. Abstract

Machin N, Ragni MV, Malec LM, Brambilla D, Coyle T, Davis JA, Drygalski A, James AH, Jobe SM, Konkle BA, Kouides P, Kuriakose P, Ma AD, Majerus EM, Nance D, Neff AT, Philipp CS, Wang TF, and Yaish HM. Von willebrand factor for menorrhagia: A survey and literature review Blood 2015; 126(23):4. PMID: Not assigned. Abstract

Malik D, Kuriakose P, Bivins D, and Church J. Single center clinical and pharmacokinetic experience with long- acting recombinant factor VIII (rFVIIIFx) and IX (rFIXFc) Haemophilia 2016; 22:101-101. PMID: Not assinged. Abstract

Mattour AH, Walbert T, Lee I, and Wang D. A revisit of the devastating outcome of leptomeningeal disease JClin Oncol 2016; 34PMID: Not assigned. Abstract

Nabi S, Adeel A, Sudasena D, Jabbar A, Bozorgnia F, and Kuriakose P. Impact of blood groups on 157 clinical outcomes in patients with von willebrand disease Blood 2015; 126(23):2. PMID: Not assigned. Abstract

Newman L, Jiagge E, Bensenhaver J, Jibril A, Awuah B, and Stark A. Comparative Analysis of Breast Cancer Phenotypes in African American, White American, and West Versus East African Patients: Correlation Between African Ancestry and Triple Negative Breast Cancer Annals of Surgical Oncology 2016; 23:S8-S8. PMID: Not assigned. Abstract

Newman LA, Jiagge E, Bensenhaver JM, Chitale D, Kleer C, Merajver S, Kyei I, Aitpillah F, Oppong J, Amankwaa- Frempong E, Adjei E, Wicha M, Awuah B, and Stark A. Comparative analysis of breast cancer phenotypes in African American, white American, and African patients-correlation between African ancestry and triple negative breast cancer Cancer Res 2016; 76(4)PMID: Not assigned. Abstract

Patel MR, Fakih M, Olszanski AJ, Lockhart AC, Drilon AE, Fu S, Bazhenova L, Patel R, Oliver JW, Multani PS, and Wang D. A phase 1 dose escalation study of RXDX-105, an oral RET and BRAF inhibitor, in patients with advanced solid tumors J Clin Oncol 2016; 34PMID: Not assigned. Abstract

Rybkin II, Kio EA, Masood A, Shum MK, Halmos B, Blakely CM, Eaton KD, Sharma N, Nemunaitis JJ, Saccaro SJ, Boumber Y, Mena RR, Mirshahidi HR, Janne PA, Christensen J, Chao RC, Tassell VR, Faltaos D, and Schreeder MT. Amethyst NSCLC trial: Phase 2, parallel-arm study of receptor tyrosine kinase (RTK) inhibitor, MGCD265, in patients (pts) with advanced or metastatic non-small cell lung cancer (NSCLC) with activating genetic alterations in mesenchymal-epithelial transition factor (MET) J Clin Oncol 2016; 34PMID: Not assigned. Abstract

Rybkin I, Smit E, Kopp HG, Kim DW, Spira A, Berruti A, Lee DH, Reguart N, Akimov M, Schumacher K, Upalawanna A, Squires M, and Tan DS. Ps01.60: Ph ib/ii, trial of inc280 +/- erlotinib vs platinum + pemetrexed in adult pts with egfr-mutated, cmet amplified, egfr tki resistant, advanced nsclc: Topic: Medical oncology J Thorac Oncol 2016; 11(11s):S307-s308. PMID: 27969527. Abstract

Saste AB, Jiang F, Arias-Stella J, Gamalski S, Peres E, Janakiraman N, and Farhan S. Emberger syndrome with concomitant GATA2, NPM1 and FLT3-ITD mutations in remission after allogeneic stem cell transplant Biol Blood Marrow Transplant 2016; 22(3):S208-S209. PMID: Not assigned. Abstract - Full Text

Saste AB, Gulati R, Kuriakose P, Inamdar K, Karner K, Carey J, and Menon M. Prognostic impact of aberrant t/NK cell marker expression in AML J Clin Oncol 2016; 34PMID: Not assigned. Abstract

Smit EF, Kopp HG, Kim DW, Tortora G, Spira AI, Berruti A, Lee DH, Reguart N, Rybkin II, Akimov M, Schumacher KM, Upalawanna A, Xu C, Squires M, and Tan DSW. GEOMETRY duo-1: A phase (Ph) Ib/II, multicenter trial of oral cMET inhibitor capmatinib (INC280) ± erlotinib vs platinum + pemetrexed in adult patients (pts) with epidermal growth factor receptor (EGFR)-mutated, cMET-amplified, locally advanced/metastatic non-small cell lung cancer (NSCLC) with acquired resistance to prior EGFR tyrosine kinase inhibitor (TKI) therapy J Clin Oncol 2016; 34PMID: Not assigned. Abstract

Tsimberidou AM, Ou Y, Xu Y, Wang Z, Harvey RD, Mita A, Sharma S, Papadopoulos K, Wang D, Pinchasik D, Demirhan E, Cutler RE, and Gore L. A phase I study of oprozomib to assess drug-drug interaction with midazolam in patients with advanced malignancies Clin Pharmacol Ther 2016; 99:S100- S100. PMID: Not assigned. Abstract

158 Hypertension and Vascular Research

Bryson TD, Szandzik D, and Harding P. Prostaglandin E2 inhibits monocyte chemotactic protein 5 production and secretion in mouse cardiac fibroblasts via EP4 receptor FASEB Journal 2016; 30PMID: Not assigned. Abstract

Caceres PS, and Ortiz PA. Role of the novel kinase TNIK on NKCC2 surface expression, phosphorylation and na reabsorption in the thick ascending limb FASEB Journal 2016; 30PMID: Not assigned. Abstract

Gordish KL, Ortiz PA, Garvin JL, and Beierwaltes WH. Enhanced dietary fructose rapidly induces salt-sensitive hypertension in rats FASEB Journal 2016; 30PMID: Not assigned. Abstract

Gupta RC, Sing-Gupta V, Palaniyandi S, and Sabbah HN. Reduced aldehyde dehydrogenase-2 activity and protein level in left ventricular myocardium of dogs with chronic heart failure J Am Coll Cardiol 2016; 67(13):1498. PMID: Not assigned. Abstract

Gutierrez A, Goleva SB, Rhoads MK, Weaver CC, Beierwaltes WH, and Osborn JL. Altered renal and circulating renin-angiotensin system does not cause spontaneous hypertension in the african green monkey FASEB Journal 2016; 30PMID: Not assigned. Abstract

Jaykumar AB, Caceres P, Ares G, Beierwaltes W, and Ortiz P. ALMS1 (Alstrom Syndrome 1), a new interacting protein of NKCC2, regulates apical NKCC2 trafficking, urinary concentration and blood pressure FASEBJournal 2016; 30 PMID: Not assigned. Abstract

Kumar N, Nakagawa P, Janic B, Romero CA, Worou ME, Peterson EL, Ongeri EE, Niyitegeka JMV, Rhaleb NE, and Carretero OA. The anti-inflammatory peptide AC-SDKP is released from thymosin β4 by meprin α and prolyl oligopeptidase FASEB Journal 2016; 30 PMID: Not assigned. Abstract

Mendez M. Renal cortical hydrogen peroxide (H2O2) stimulates renin release from juxtaglomerular (JG) cells and increases blood pressure: Role of JG cell NOX4 FASEB Journal 2016; 30 PMID: Not assigned. Abstract

Nakagawa P, Xu J, Bordcoch G, Janic B, and Carretero OA. Inhibition of neutrophil chemotaxis by N-acetyl-seryl- aspartyl-lysyl-proline and thymosin β4 FASEB Journal 2016; 30 PMID: Not assigned. Abstract

Romero C, Monu S, Cabral G, Knight R, and Carretero O. Os 21-02 connecting tubule-glomerular feedback (ctgf) in renal hemodynamics and blood pressure regulation after unilateral nephrectomy (unx) J Hypertens 2016; 34 Suppl 1 - ISH 2016 Abstract Book:e235. PMID: 27754097. Abstract

Tackett S, Alsafadi MY, Hegab S, Mendez M, and Thavarajah K. Pulmonary alveolar proteinosis (PAP) after initiation of amiodarone and ticagrelor Chest 2016; 150(4):814A. PMID: Not assigned. Abstract

Zhu L, Xu J, Harding P, and Yang XP. Role of ACE2 in the cardioprotective effects of angiotensin II type 2 receptors FASEB Journal 2016; 30 PMID: Not assigned. Abstract

159 Infectious Diseases

Arshad S, Hartman P, Perri MB, Moreno D, and Zervos MJ. Ceftaroline fosamil for treatment of methicillin-resistant staphylococcus aureus hospital-acquired pneumonia and health care–associated pneumonia: A 5-year matched case-control evaluation of epidemiology and outcomes Infect Dis Clin Pract 2016;PMID: Not assigned. Article Request Form?

Bourgi K, Choi W, Nakhle A, Abdel-Rahman Z, Abreu-Lanfranco O, Ramesh M, Patel A, Del Busto R, and Alangaden G. Risk factors for single and recurrent symptomatic urinary tract infections within the first year after kidney transplantation Am J Transplant 2016; 16:778-779. PMID: Not assigned. Abstract

Bourgi K, Brar I, and Baker-Genaw K. Hepatitis C screening and linkage to care at a comprehensive health system Topics in Antiviral Medicine 2016; 24(E-1):209. PMID: Not assigned. Abstract

Dankerlui D, Parke D, Prentiss T, Zervos J, Plum A, Tamler I, Kaljee L, and P K. Henry ford health system global health initiative’s ‘research training to research project model.’ CUGH Global Health Conference 2016;PMID: Not assigned - Abstract.

Gentile J, and Chen A. Chronic necrotizing aspergillosis Chest 2016; 150(4):167A. PMID: Abstract

Gregory A, Chami E, and Pietsch J. Emotional motivators: Using visual triggers as an infection control intervention to increase hand hygiene compliance throughout the hospital Am J Infect Control 2016; 44(6):S3. PMID: Not Assigned. Abstract

Huprikar S, Casner L, Camera Pierrotti L, Nellore A, Madan R, Garcia-Diaz J, Jacobs S, Lee D, Trindade Clemente W, Alangaden G, La Hoz R, Theodoropoulos N, Miceli M, Santoro-Lopes G, Banach D, Simon D, and Patel G. Outcomes associated with carbapenem-resistant enterobacteriaceae infection after solid organ transplantation in a multicenter study Am J Transplant 2016; 16:403. PMID: Not assigned. Abstract

Huprikar S, Casner L, Pouch S, Pinheiro Freire M, Madan R, Kwak E, Satlin M, Hartman P, Pisney L, Henrique Mourão P, La Hoz R, and Patel G. Prior infection or colonization with carbapenem-resistant enterobacteriaceae is not an absolute contraindication for solid organ transplantation Am J Transplant 2016; 16:260. PMID: Not assigned. Abstract

Meighani A, Ramesh M, and Salgia R. Successful outcomes of fecal microbiota transplantation in patients with chronic liver disease Hepatology 2016; 63(1):1016A-1017A. PMID: Not assigned. Abstract

Parekh R, Ramesh MS, and Tang J. Lymphocytic colitis in patients with recurrent clostridium difficile colitis: Case series Am J Gastroenterol 2016; 111:S1308. PMID: Not assigned. Abstract

Plum AJ, Mucha R, Tamler I, Zervos JM, Hammer PJ. Applying the United Nations Sustainable Development Goals in the United States as a Framework for Local Action in Low-Income Communities: A Workshop Forum for Sustainable Development in Detroit, Michigan Twelfth International Conference on Environmental, Cultural, Economic, and Social Sustainability 2016;PMID: Not assigned - Abstract.

Ramesh MS, Khanna S, Messer J, and Adams M. Durable prevention of recurrent C. Difficile infection with RBX2660: Results of the PUNCH CD 2 trial Am J Gastroenterol 2016; 111:S93. PMID: Not assigned. Abstract

160 Nephrology

Bourgi K, Choi W, Nakhle A, Abdel-Rahman Z, Abreu-Lanfranco O, Ramesh M, Patel A, Del Busto R, and Alangaden G. Risk factors for single and recurrent symptomatic urinary tract infections within the first year after kidney transplantation Am J Transplant 2016; 16:778-779. PMID: Not assigned. Abstract

Moza A, Khan A, Prashar R, Khan S, Khouri S, Vetteth S, Malhotra D, Rees M, Moukarbel G, and Ortiz J. Pulmonary hypertension in renal transplant candidates: A systematic review and meta-analysis of the available evidence Am J Transplant 2016; 16:573. PMID: Not assigned. Abstract

Neyra JA, Canepa-Escaro F, Yee J, and Yessayan L. Hyperchloremia versus nonhyperchloremia or hyperchloremia versus normochloremia? Reply Crit Care Med 2016; 44(1):E53-E54. PMID: Not assigned. Abstract

Prashar R, Goggins M, Yessayan L, Patel A, and Goggins M. Focal C4d staining in biopsies of kidney transplant recipients is not associated with antibody mediated rejection and does not correlate with graft survival Am J Transplant 2016; 16:702. PMID: Not assigned. Abstract

Rodriguez J, Patel A, and Goggins M. Age gap analysis between live donor and recipients in kidney transplantation: Opportunities to improve voluntary exchange programs and kidney paired donation Am J Transplant 2016; 16:450. PMID: Not assigned. Abstract

Singasani R, Goggins M, Patel A, and Venkat K. Liver transplant alone or simultaneous liver kidney transplantation? Case report illustrating dilemmas in patient selection for dual transplantation Am J Kidney Dis 2016; 67(5):A101. PMID: Not assigned. Abstract

Singasani R, Ngansop T, Kumbar L, Li J, Yee J, and Yessayan L. Renal sparing in levamisole/cocaine induced systemic vasculitis Am J Kidney Dis 2016; 67(5):A101. PMID: Not assigned. Abstract

Tinney F, Yessayan L, Abouljoud M, and Patel A. Characterization of vascular lesions in living donor renal transplant implant biopsies Am J Transplant 2016; 16:646. PMID: Not assigned. Abstract

161 Pulmonary and Critical Care Medicine

Abrencillo R, Simoff M, Smoot T, Ray C, Aljasmi M, Jennings J, and Yessayan L. Diphenhydramine as an adjunct to conscious sedation in bronchoscopy Chest 2016; 150(4):980A. PMID: Not assigned. Abstract

Abu Sayf A, Nakhle A, Tatem G, and Polevoy R. Prolymphocytoid transformation of a splenic B- cell lymphoma presenting as a spontaneous splenic rupture Chest 2016; 150(4):258A. PMID: Not assigned. Abstract

Abu Sayf A, Virk F, and Tatem G. A case of catastrophic antiphospholipid antibody syndrome Chest 2016; 150(4):233A. PMID: Abstract

Aljasmi M, Kareem Uduman A, Gashouta M, Wong H, Bazan L, Mordis C, and Roehrs T. CPAP in OSA patients and post-operative outcomes Chest 2016; 150(4):1279A. PMID: Not assigned. Abstract

Alsafadi MY, Mawri S, Shah J, Jain T, Dirani G, Nakhle A, Abdelrahim E, Michaels A, Huda N, and Ananthasubramaniam K. Inferior Vena Cava diameter as a predictor of mortality in septic shock Chest 2016; 150(4):366A. PMID: Not assigned. Abstract

Blum E, Thavarajah K, and Smith AL. Optimization of patient-specific inhaler regimens: A pharmacy-pulmonology collaborative pilot program in the ambulatory care setting Chest 2016; 150(4):635A. PMID: Not assigned. Abstract

Chaaban S, Samuel G, and Awdish R. Aggressively targeting the inflammatory pathway in SLE- PAH improved hemodynamics and allowed for titration off prostacyclin Chest 2016; 150(4):906A. PMID: Not assigned. Abstract

Chasteen K, Awdish R, Mendez M, Buick D, and Kokas M. Clear conversations: A comprehensive curriculum to facilitate translation of skills learned in simulated settings to improve communication in real clinical encounters J Pain Symptom Manage 2016; 51(2):384-385. PMID: Not assigned. Abstract

Demos D, Divine G, Paone G, Borgi J, Morgan J, Allenspach L, Stagner L, and Nemeh H. Abo compatibility in lung transplantation J Heart Lung Transplant 2016; 35(4):S368. PMID: Not assigned. Abstract

Diaz M, Chang S, and Singer M. Adherence to dietary indexes by diabetes and hypertension status among PLCO cancer screening trial participants Adv Nutr 2016; 7(1):38A. PMID: Not assigned. Abstract

Farha R, Usman M, Gandolfo C, Smith A, and Ouellette D. Potential protective effect of PPI in COPD Chest 2016; 150(4):833A. PMID: Not assigned. Abstract

Kelly B, and Lazar M. Spontaneous bladder rupture diagnosed by pleural fluid analysis Chest 2016; 150(4):1140A. PMID: Not Assigned. Abstract

Rezik M, Onyenekwe J, Farha R, and Ouellette D. A rare case of pulmonary plasmacytoma secondary to multiple myeloma Chest 2016; 150(4):1093A. PMID: Not assigned. Abstract

Sareen N, Mariychina A, Hector C, Mahan M, and Ananthasubramaniam K. Do right ventricular diastolic tissue doppler parameters add diagnostic value in pulmonary hypertension? J Am Soc Echocardiogr 2016; 29(6):B101. PMID: Not assigned. Abstract

Sayf AA, Tatem G, and Makki H. Unilateral endoluminal stenosis secondary to pulmonary sarcoidosis Chest 2016; 150(4):1053A. PMID: Not assigned. Abstract

Sengupta R, Aljasmi M, Jain T, and Hegab S. Presentation of sub-massive pulmonary embolism mimicking acute liver failure Chest 2016; 150(4):429A. PMID: Not assigned. Abstract

Tackett S, Alsafadi MY, Hegab S, Mendez M, and Thavarajah K. Pulmonary alveolar proteinosis (PAP) after initiation of amiodarone and ticagrelor Chest 2016; 150(4):814A. PMID: Not assigned. 162 Abstract

Vance S, Al Feghali KA, Taylor A, Kaur M, Neslund-Dudas C, Chetty IJ, Simoff M, Ajlouni M, and Movsas B. Do race and income influence quality of life (QOL) or survival outcomes after lung stereotactic body radiation therapy (SBRT)? a prospective study Int J Radiat Oncol Biol Phys 2016; 96(2s):E534. PMID: 27674948. Full Text Abstract

163 Pulmonary/Sleep Medicine

Aljasmi M, Kareem Uduman A, Gashouta M, Wong H, Bazan L, Mordis C, and Roehrs T. CPAP in OSA patients and post-operative outcomes Chest 2016; 150(4):1279A. PMID: Not assigned. Abstract

Carr AN, Ramsey DL, Brum JM, Thomas P, Kappler G, Chan K, Koshorek G, and Roth T. Diphenhydramine HCL improves both objective and subjective sleep parameters in an occasional sleeplessness population Sleep 2016; 39:A212. PMID: Not assigned. Abstract

Cheng P, Tran M, Tallent G, Pillai V, Cuamatzi A, Bazan L, Moss K, and Drake CL. Circadian misalignment and cognitive flexibility in night shift workers Sleep 2016; 39:A173. PMID: Not assigned. Abstract

Demos D, Divine G, Paone G, Borgi J, Morgan J, Allenspach L, Stagner L, and Nemeh H. Abo compatibility in lung transplantation J Heart Lung Transplant 2016; 35(4):S368. PMID: Not assigned. Abstract

Durrence H, Drake CL, Tran KM, Bazan L, Cheng P, Pillai V, and Roth T. Double-blind, placebo- controlled, 4-way crossover study comparing the effects of doxepin 6 MG and zolpidem 10 MG on gait, balance, and cognitive performance in healthy volunteers Sleep 2016; 39:A206. PMID: Not assigned. Abstract

Durrence H, Roth T, Tran KM, Singh M, Cheng P, Pillai V, and Drake C. Arousability of insomnia patients and healthy volunteers is not impacted by the sleep-specific doses of doxepin (3 MG and 6 MG), but is impacted in healthy volunteers using zolpidem 10 MG Sleep 2016; 39:A201. PMID: Not assigned. Abstract

Fellman-Couture C, Pillai V, Arnedt J, Anderson J, Moss K, Roth T, and Drake C. Long-term efficacy of cognitive behavior therapy for menopausal insomnia Sleep 2016; 39:A198-A199. PMID: Not assigned. Abstract

Goldschmied JR, Cheng P, Armitage R, and Deldin P. Accumulation and dissipation of slow-wave activity andthe effect on mood disturbance Sleep 2016; 39:A304. PMID: Not assigned. Abstract

Gordon VH, Dhand R, Dudney T, Shamiyeh J, Heidel R, and Roehrs T. Total sleep time strongly correlates withself- reported hospital admissions; an inpatient COPD cohort survey Sleep 2016; 39:A269. PMID: Not assigned. Abstract

Jarrin DC, Chen IY, Ivers H, Lamy M, Drake CL, and Morin CM. Temporal stability of the ford insomnia response to stress test (FIRST) Sleep 2016; 39:A195. PMID: Not assigned. Abstract

Palagini L, Bruno RM, Cheng P, Mauri M, Taddei S, Ghiadoni L, Drake CL, and Morin CM. Relationship between insomnia symptoms, perceived stress and coping strategies in subjects with arterial hypertension: Psychological factors may play a modulating role Sleep Med 2016; 19:108-115. PMID: Not yet assigned. Abstract

Palagini L, Mazzei I, Cipollone G, Mauri M, and Drake CL. The role of attachment style in stress perception and reactivity in Insomnia Disorder Sleep 2016; 39:A186. PMID: Not assigned. Abstract

Pillai V, Kalmbach D, Arnedt J, and Drake CL. Sleep system sensitization: Evidence for changing roles of etiological factors in insomnia Sleep 2016; 39:A186. PMID: Not assigned. Abstract

Pillai V, Tran KM, Roth T, and Drake CL. Limitations of current diagnostic criteria for insomnia: A casefor quantitative cut-offs Sleep 2016; 39:A198. PMID: Not assigned. Abstract

Roehrs T, Koshorek G, Withrow D, and Roth T. Cortisol and hyperarousal in insomnia Sleep 2016; 39:A201. PMID: Not assigned. Abstract

164

Roehrs T, Koshorek G, Withrow D, Tancer M, and Roth T. How representative are insomnia clinical trials? Sleep 2016; 39:A198. PMID: Not assigned. Abstract

Verster JC, Peters LV, Van De Loo AJ, Bouwmeester NH, Tiplady B, Alford C, and Roth T. Meta- analysis on the next-morning effects of hypnotic drugs on short- and long-term memory functioning in healthy adults and elderly Sleep 2016; 39:A210-A211. PMID: Not assigned. Abstract

Verster JC, Peters LV, Van De Loo AJAE, Bouwmeester NH, Tiplady B, Alford C, and Roth T. Next- morning effects of hypnotic drugs on attention, psychomotor performance, and memory functioning: Implications for traffic safety J Sleep Res 2016; 25:126-127. PMID: Not assigned. Abstract

Verster JC, Fernstrand AM, Van De Loo AJAE, Roth T, and Garssen J. The impact of dietary intake of tryptophan, niacin, and vitamin B6 on sleep Journal of Sleep Research 2016; 25:127. PMID: Not assigned. Abstract

165 General Internal Medicine/Palliative Medicine/Other

Abu Sayf A, Nakhle A, Tatem G, and Polevoy R. Prolymphocytoid transformation of a splenic B- cell lymphoma presenting as a spontaneous splenic rupture Chest 2016; 150(4):258A. PMID: Not assigned. Abstract

Abu Sayf A, Virk F, and Tatem G. A case of catastrophic antiphospholipid antibody syndrome Chest 2016; 150(4):233A. PMID: Abstract

Aguin V, Bhatti F, El Atrache M, and Kaur N. An unusual case of polypoid vascular ectasia Am J Gastroenterol 2016; 111:S732-S733. PMID: Not assigned. Abstract

Aguin V, Meighani A, Hussain S, Atrache ME, Elbatta M, Bukannan A, Jafri SM, and Ibrahim M. Elevated head of the bed, a novel position for performing colonoscopy: Does it improve the quality of the examination? Am J Gastroenterol 2016; 111:S141. PMID: Not assigned. Abstract

Alsafadi MY, Mawri S, Shah J, Jain T, Dirani G, Nakhle A, Abdelrahim E, Michaels A, Huda N, and Ananthasubramaniam K. Inferior Vena Cava diameter as a predictor of mortality in septic shock Chest 2016; 150(4):366A. PMID: Not assigned. Abstract

Arnautovic J, Brown P, and Tereziu S. Omesartan induced sprue-like enteropathy Am J Gastroenterol 2016; 111:S1364. PMID: Not assigned. Abstract

Arnautovic J, Mazhar A, and Tereziu S. Isolated congenital asplenia: A rare case of small bowel arteriovenous malformation associated bleeding and literature review Am J Gastroenterol 2016; 111:S1365. PMID: Not assigned. Abstract

Barnes G, Cole D, Gu X, Haymart B, Kline-Rogers E, Almany S, Dahu M, Ekola M, Kozlowski J, Krol G, McNamara M, Kaatz S, and Froehlich J. Effectiveness of implementing an extended INR testing interval for stable warfarin patients: Results from the MAQI2 collaborative of anticoagulation clinics J Thromb Haemost 2016; 14:20-21. PMID: Not assigned Abstract

Bourgi K, Choi W, Nakhle A, Abdel-Rahman Z, Abreu-Lanfranco O, Ramesh M, Patel A, Del Busto R, and Alangaden G. Risk factors for single and recurrent symptomatic urinary tract infections within the first year after kidney transplantation Am J Transplant 2016; 16:778-779. PMID: Not assigned. Abstract

Brown P, Parekh R, and Zalawadia A. A rare case of abdominal tuberculosis Am J Gastroenterol 2016; 111:S1032- S1033. PMID: Not assigned. Abstract

Carlyle L, Wang DD, Taylor A, Swanson B, Wyman J, Pantelic M, Song T, Eng M, Paone G, Greenbaum A, and O'Neill W. No two systoles the same: Personalizing transcatheter heart valve selection for transcatheter aortic valve replacement J Am Coll Cardiol 2016; 67(13):327. PMID: Not assigned. Abstract

Chaaban S, Samuel G, and Awdish R. Aggressively targeting the inflammatory pathway in SLE- PAH improved hemodynamics and allowed for titration off prostacyclin Chest 2016; 150(4):906A. PMID: Not assigned. Abstract

Chasteen K, Awdish R, Mendez M, Buick D, and Kokas M. Clear conversations: A comprehensive curriculum to facilitate translation of skills learned in simulated settings to improve communication in real clinical encounters J Pain Symptom Manage 2016; 51(2):384-385. PMID: Not assigned. Abstract

Farha R, Usman M, Gandolfo C, Smith A, and Ouellette D. Potential protective effect of PPI in COPD Chest 2016; 150(4):833A. PMID: Not assigned. Abstract

Gentile J, and Chen A. Chronic necrotizing aspergillosis Chest 2016; 150(4):167A. PMID: Abstract

Gibbs J, Mansour M, Mawri S, Nasr Y, Sudasena D, and Ananthasubramaniam K. The value of

166 additional testing after non-diagnostic stress echocardiography in patients presenting with chest pain: A single-center analysis JAm Coll Cardiol 2016; 67(13):520. PMID: Not assigned. Abstract

Gill B, Soman S, and Bhan A. Comparison of the glasgow-blatchford risk score vs aims65 score in patients on coumadin and anti-platelet therapy or dual anti-platelet therapy Am J Gastroenterol 2016; 111:S494-S495. PMID: Not assigned. Abstract

Hart BR, El Atrache M, and Zalawadia A. A rare case of simultaneous metastatic disease of renal cell carcinoma to the stomach, bone, and lungs Am J Gastroenterol 2016; 111:S1143-S1144. PMID: Not assigned. Abstract

Hart BR, Sedki M, Bukannan A, Zalawadia A, Blumenkehl M, and Jafri SM. Retrospective analysis of specific vs non-specific beta blockers for variceal bleed Am J Gastroenterol 2016; 111:S1262-S1264. PMID: Not assigned. Abstract

Jiang F, Cabrera Fernandez DF, Church J, Gulati R, Taylor A, Menon M, and Kuriakose P. Correlation between peripheral blood counts and day 14 bone marrow biopsy in acute myeloid leukemia during induction chemotherapy Blood 2015; 126(23):3. PMID: Not assigned. Abstract

Joshi S, Vanderhoek M, and Harkness B. CdZnTe detectors: What you need to know J Nucl Med 2016; 57PMID: Not assigned. Abstract

Kothari S, Thakkar S, Rao B, Kothari T, Garg MS, and Kaul V. Multimodal treatment approach for migrated and epithelialized metal biliary stents Am J Gastroenterol 2016; 111:S183. PMID: Not assigned. Abstract

Lenhart A, Folt D, Markus J, Cerasale M, and Moonka D. A rare case of a sex cord stromal tumor presenting as elevated liver function tests Am J Gastroenterol 2016; 111:S864-S865. PMID: Not assigned. Abstract

Lenhart A, Hassan M, Meighani A, Sadiq O, and Siddiqui Y. A perplexing case of abdominal pain that led to the diagnosis of zollinger-ellison syndrome Am J Gastroenterol 2016; 111:S1056. PMID: Not assigned. Abstract

Mawri S, Alsafadi MY, Jain T, Al-Darzi W, Shah J, Michaels A, Gibbs J, Dirani G, Albashaireh D, and Ananthasubramaniam K. Diastolic dysfunction in septic shock: Insights from echocardiography Chest 2016; 150(4):355A. PMID: Not assigned. Abstract

Meighani A, Hassan M, Lenhart A, and Gordon S. Aortitis in a patient with chronic hepatitis C virus infection Am J Gastroenterol 2016; 111:S870-S871. PMID: Not assigned. Abstract

Meighani A, Ramesh M, and Salgia R. Successful outcomes of fecal microbiota transplantation in patients with chronic liver disease Hepatology 2016; 63(1):1016A-1017A. PMID: Not assigned. Abstract

Meighani A, Rao B, Hassan M, Abboud R, and Pompa R. Does presenting with an acute diverticular bleed prior to the weekend result in a longer wait time to colonoscopy? Am J Gastroenterol 2016; 111:S1227-S1228. PMID: Not assigned. Abstract

Michaels AT, Radjef R, She RC, Liu B, Peterson E, Pinto Y, Williams K, Sabbah H, and Lanfear D. Improving risk prediction in heart failure: MAGGIC plus natriuretic peptides J Card Fail 2016; 22(8):S99- S99. PMID: Not assigned. Abstract

Michaels AT, Radjef R, She R, Peterson E, Liu B, and Lanfear DE. Predicting mortality at discharge following hospitalization for acute heart failure J Card Fail 2016; 22:S21-S22. PMID: Not assigned. Abstract

Muller CC, McCord J, Michaels A, Nowak R, Giannitsis E, Body R, Christ M, Lindahl B, DeFilippi C, Christenson R, Bendig G, Jacobsen G, and Mueller C. Symptoms predictive of acute myocardial 167 infarction in the troponin era: Analysis from the TRAPID-AMI study J Am Coll Cardiol 2016; 67(13):518. PMID: Not assigned. Abstract

Nabi S, Adeel A, Sudasena D, Jabbar A, Bozorgnia F, and Kuriakose P. Impact of blood groups on clinical outcomes in patients with von willebrand disease Blood 2015; 126(23):2. PMID: Not assigned. Abstract

Radjef R, Michaels A, Peterson E, She R, Liu B, Williams K, Sabbah H, and Lanfear D. Performance of MAGGIC score in african americans compared to whites J Card Fail 2016; 22(8):S101- S101. PMID: Not assigned. Abstract

Rahman M. Pulmonary hypertension inappropriately who group classified secondary to mass effect J Am Coll Cardiol 2016; 67(13):1105. PMID: Abstract

Ramesh MS, Khanna S, Messer J, and Adams M. Durable prevention of recurrent C. Difficile infection with RBX2660: Results of the PUNCH CD 2 trial Am J Gastroenterol 2016; 111:S93. PMID: Not assigned. Abstract

Rao B, Yoshida A, Ibrahim M, and Jafri SM. The use of perioperative lactate values as markers for adverse outcomes in liver transplantation Am J Transplant 2016; 16:672. PMID: Not assigned. Abstract

Rao B, Markus J, Bukannan A, Parekh R, and Moonka D. Acute pulmonary embolism masquerading as acute liver failure Am J Gastroenterol 2016; 111:S946. PMID: Not assigned. Abstract

Rezik M, and Mattina D. Severe cardiomyopathy secondary to anti-TNF therapy for crohn's disease J Am Coll Cardiol 2016; 67(13):1042. PMID: Not assigned. Abstract

Rezik M, Onyenekwe J, Farha R, and Ouellette D. A rare case of pulmonary plasmacytoma secondary to multiple myeloma Chest 2016; 150(4):1093A. PMID: Not assigned. Abstract

Rodriguez J, Patel A, and Goggins M. Age gap analysis between live donor and recipients in kidney transplantation: Opportunities to improve voluntary exchange programs and kidney paired donation Am J Transplant 2016; 16:450. PMID: Not assigned. Abstract

Sengupta R, Aljasmi M, Jain T, and Hegab S. Presentation of sub-massive pulmonary embolism mimicking acute liver failure Chest 2016; 150(4):429A. PMID: Not assigned. Abstract

Siddiqui MA, Eraqi H, Omar S, and Jafri SM. Massive disparity in insurance approval; a comparison between ledipasvir/sofosbuvir based hepatitis C therapy and adalimumab based IBD therapy Hepatology 2016; 63(1):474A. PMID: Not assigned. Abstract

Siddiqui MA, Iraqi H, Aggarwal R, Varma A, El Atrache M, and Jafri SM. Insurance approval rates for medicaid patients: A comparison between ledipasvir/sofosbuvir based hepatitis C therapy and adalimumab based IBD therapy Am J Gastroenterol 2016; 111:S365. PMID: Not assigned. Abstract

Siddiqui MA, Tang J, Khan S, El Atrache M, Varma A, Aggarwal R, and Jafri SM. A case of necrotising pancreatitis following ampullary biopsy Am J Gastroenterol 2016; 111:S549-S550. PMID: Not assigned. Abstract

Small B, Mitchell G, Hrabec D, Selim R, and Wang DD. Hyperandrogenism and spontaneous coronary artery dissection: A new entity? Chest 2016; 150(4):89A. PMID: Not assigned. Abstract

Souther B, Arnautovic J, and Singh G. Ischemic colitis complicated by consumptive coagulopathy Am J Gastroenterol 2016; 111:S1306-S1307. PMID: Not assigned. Abstract

Tackett S, Alsafadi MY, Hegab S, Mendez M, and Thavarajah K. Pulmonary alveolar proteinosis (PAP) after initiation of amiodarone and ticagrelor Chest 2016; 150(4):814A. PMID: Not assigned. Abstract

168 Tirgari S, Markin A, and Kobylak L. Large mature teratoma presenting as incidental mediastinal mass on chest radiograph Chest 2016; 150(4):806A. PMID: Not assigned. Abstract

Weick A, Sadiq O, Jafri SM, and Moonka D. Initial experience with ledipasvir-sofosbuvir based therapy for recurrent hepatitis C after liver transplantation Am J Transplant 2016; 16:793. PMID: Not assigned. Abstract

Wilkinson J, Kong XW, Almany S, Kozlowski J, Krol G, McNamara M, Kaatz S, Froehlich JB, and Barnes GD. The predictive ability of various risk scores for bleeding in warfarin-treated vte patients Vascular Medicine 2016; 21(3):307-307. PMID: Not assigned. Abstract

169 NEUROLOGY

Affan M, Schultz L, Cerghet M, and Elias S. Clinical and radiological presentation of neurosarcoidosis: Single center cohort study of 107 cases (p6.114) Neurology 2016; 86(16 Supplement)PMID: Not assigned. Abstract

Bagher-Ebadian H, Schwalb J, Mahmoudi F, Air E, Shokri S, Nazem-Zadeh M, Spanaki-Varelas M, Wasade V, and Soltanian-Zadeh H. Localized quantitative analysis of positron emission tomography (PET) for temporal lobe epilepsy lateralization and surgical intervention J Nucl Med 2016; 57PMID: Not assigned. Abstract

Brown SL, Elmghirbi R, Nagaraja T, Keenan KA, Lapanowski K, Panda S, Inder P, Cabral G, Liu L, Kim JH, Movsas B, Chetty IJ, Ewing JR, and Parry R. Toward a noninvasive measurement of cancer stem cells and tumor aggressiveness Int J Radiat Oncol Biol Phys 2016; 96(2s):E592. PMID: 27675105. Full Text Abstract

Bulka H, Croll S, Elias S, and Cerghet M. Paroxysmal dystonia in inflammatory disorders of the central nervous system. A southeastern michigan cohort study CMSC Annual Meeting 2016;PMID: Not assigned. Abstract

Buller B, Moore T, Zhang Y, Pikula E, Martin C, Mortazavi F, Rosene D, Chopp M, and Zhang Z. Exosomes from rhesus monkey MSCs promote neuronal growth and myelination Stroke 2016; 47PMID: Not assigned. Abstract

Cheung WL, Chopp M, Zhang T, Zhang ZG, and Morris D. Irisin induces neurite outgrowth in primarycortical neurons Brain Injury 2016; 30(5-6):497-498. PMID: Not assigned. Abstract

Chopp M. Treatment of stroke and neural injury with exosomes and miRNA cargo Journal of Cerebral Blood Flow and Metabolism 2016; 36:8. PMID: Not assigned. Abstract

Cui C, Chopp M, Ye X, Zacharek A, Ning R, Yan T, Cui X, Yu P, Roberts C, and Chen J. Mir-145 mediates bone- marrow-stromal cell derived from type-one diabetes (t1dm) rats induced neurorestorative effects in T1DM rats Stroke 2016; 47PMID: Not assigned. Abstract

Cui X, Chen J, Zacharek A, Cui Y, Roberts C, and Chopp M. ABCA1/HDL pathway mediates GW3965 induced neurorestoration and white matter remodeling after stroke Stroke 2016; 47PMID: Not assigned. Abstract

Dehkordi AN, Kamali-Asl A, Ewing JR, and Bagher-Ebadian H. An adaptive model for direct estimation of extravascular-extracellular space in dynamic contrast-enhanced magnetic resonance imaging studies Int J Radiat Oncol Biol Phys 2016; 96(2s):E644. PMID: 27675247. Full Text Abstract

Dharia RM, Davoodi-Bojd E, Jing Q, Li L, Cerghet M. Analysis of white matter tracts of resting state cognitive networks in multiple sclerosis Int J MS Care 2016; 18(9s1):62. PMID: Not assigned. Abstract

Girotra T, Baki N, and Grover K. Rituximab for refractory myasthenia gravis in a pregnant patient Neurology 2016; 86(16)PMID: Not assigned. Abstract

Jackson C, George A, Sherman M, Verma A, Shefner J, Scelsa S, Newman D, Kasarskis E, and Heiman-Patterson Early treatment with NIPPV: Factors affecting compliance over time Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 2016; 17:45-46. PMID: Not assigned. Abstract

Kaveeshvar H, Kashouty R, and Loomba V. Spontaneous carotid dissection in a patient after incidental amphetamine salt overdose presenting as cluster like headache Neurology 2016; 86(16)PMID: Not assigned. Abstract

Lewitt P, Freed M, Leinonen M, Sedkov A, and Murck H. Effect of patient characteristics on motor function in response to 35-50 mg of inhaled levodopa (CVT-301) in patients with Parkinson's disease: Results from a phase 2b study Neurology 2016; 86(16)PMID: Not assigned. Abstract

170

LeWitt P, Niyazov A, Sedkov A, Murck H, and Guo A. Patients' experience of Parkinson's disease following treatment with inhaled Levodopa: Results from a phase 2b study Neurology 2016; 86(16)PMID: Not assigned. Abstract

Li C, Zhang Y, Levin AM, Chopp M, and Zhang ZG. Characterization of micrornas and their target proteins in distal axons of cortical neurons Stroke 2016; 47PMID: Not assigned. Abstract

Mahajan A, and Sidiropoulos C. Myoclonus dystonia: A report of two rare mutations Mov Disord 2016; 31:S191. PMID: Not assigned. Abstract

Maturu S, Dayyoub T, Schultz L, Snyder J, Wasade V, Elsayed M, Gaddam S, Mahmood N, Constantinou J, Barkley G, Spanaki-Varelas M, and Zillgitt A. Outcomes of genetic generalized epilepsy at acomprehensive epilepsy center Neurology 2016; 86(16)PMID: Not assigned. Abstract

Mehta C, Jones M, Cuero MR, Wellwood J, Rehman M, Mitsias P, and Varelas P. Intracranial hemorrhage on warfarin: Time to reversal is of the essence Neurology 2016; 86(16)PMID: Not assigned. Abstract

Morris D, Chopp M, Cheung WL, Cui Y, Zhang T, Lu M, Zhang L, and Zhang ZG. Thymosin β4 for the treatment of sub-acute stroke in aged rats Stroke 2016; 47PMID: Not assigned. Abstract

Munkarah AR, Kim S, Buekers TE, Chhina J, Poisson L, Giri S, and Rattan R. Metabolic effects of metformin treatment in ovarian cancer cell lines Gynecol Oncol 2016; 141:168. PMID: Not assigned. Abstract

Munkarah A, Hamid S, Chhina J, Mert I, Jackson L, Hensley-Alford S, Chitale D, Giri S, and Rattan R. Targeting of free fatty acid signaling in ovarian cancer may serve as a potential therapeutic approach Clin Cancer Res 2016; 22PMID: Not assigned. Abstract

Nagaraja TN, Keenan KA, Ewing JR, and Knight RA. Surrogate MRI signatures for contrast enhanced imaging that predict acute blood-brain barrier damage in ischemia-reperfusion Stroke 2016; 47PMID: Not assigned. Abstract

Naqvi I, Katramados A, and Agarwal R. Arachnoid cyst with intracystic hemorrhage in a child: Need for vigilance and prompt treatment Neurology 2016; 86(16)PMID: Not assigned. Abstract

Rattan R, Mert I, Chhina J, Hamid S, Hijaz M, Poisson L, Hensley Alford S, Giri S, and Munkarah AR. Targeting of free fatty acid receptor 1 in EOC: A novel strategy to restrict the adipocyte-EOC dependence Gynecol Oncol 2016; 141:47. PMID: Not assigned. Abstract

Romero C, Monu S, Cabral G, Knight R, and Carretero O. Os 21-02 connecting tubule-glomerular feedback (ctgf) in renal hemodynamics and blood pressure regulation after unilateral nephrectomy (unx) J Hypertens 2016; 34 Suppl 1 - ISH 2016 Abstract Book:e235. PMID: 27754097. Abstract Sakr S, Giri S, Rattan R, Abdulfatah E, Pardeshi V, Morris RT, Munkarah AR, and Ali-Fehmi R. Expression of alcohol dehydrogenase 5 in ovarian carcinoma: Effect on prognosis and therapeutic potential Gynecol Oncol 2016; 141:67. PMID: Abstract

Shehadah A, Kassis H, Li C, Zhang Y, Cui Y, Roberts C, Sadry N, Liu X, Chopp M, and Zhang ZG. Class IIa histone deacetylases are essential for neuronal remodeling and functional recovery after stroke Stroke 2016; 47PMID: Not assigned. Abstract

Snyder J, Scarpace L, Schultz L, and Walbert T. The role of neuro-oncology tumor boards at academic centers in the United States Neuro-Oncology 2016; 18:iv82. PMID: Not assigned. Abstract

Sripathi N, and Grover K. Cardiac conduction defects in oculopharyngeal muscular dystrophy Neurology 2016; 86(16)PMID: Not assigned. Abstract

Taylor M, Mert I, Hijaz M, Chhina J, Morris RT, Giri S, Rattan R, and Munkarah AR. Effects of an

171 olaparib and metformin combination on the AMPK and DNA-damage pathways in ovarian cancer Gynecol Oncol 2016; 141:197- 198. PMID: Not assigned. Abstract

Tzagournissakis M, Spanaki C, Amoiridis G, Plaitakis A, and Mitsias P. Familial amyloidotic polyneuropathy in Crete, Greece Neurology 2016; 86(16)PMID: Not assigned. Abstract

Venkat P, Chopp M, Zacharek A, Ning R, Roberts C, and Chen J. A multiple microinfarction based animal model for vascular dementia J Cereb Blood Flow Metab 2016; 36:217. PMID: Not assigned. Abstract

Wang H, Robinson J, Varelas P, Henderson G, Wijdicks E, and Greer D. Variability of brain death policies in the united states Neurology 2016; 86(16)PMID: Not assigned. Abstract

Xin H. Secondary release of exosomes from astrocytes contributes to neural plasticity and improvement of functional recovery after stroke in rats treated with IA administration of exosomes harvested from miR-133b-enriched MSCs J Extracell Vesicles 2016; 5:17. PMID: Not assigned. Abstract

Yacoby-Zeevi O, Zawoznik E, Weinstock I, Nemas M, Caraco Y, LeWitt P, Oren S, and Shaltiel-Karyo R. Continuous subcutaneous administration of carbidopa enhances levodopa pharmacokinetics: A series of studies conducted in the pig, mouse and healthy volunteers Neurology 2016; 86(16)PMID: Not assigned. Abstract

Zahoor S, Kaveeshvar H, and Loomba V. Pain as the presenting symptom of primary progressive multiple sclerosis Neurology 2016; 86(16)PMID: Not assigned. Abstract

Zhang RL, Chopp M, Pan W, Zhang X, Liu X, Wei M, Roberts C, Wang X, and Zhang ZG. Inducible conditional deletion of dicer in neural progenitor cells induces cognitive impairment Stroke 2016; 47PMID: Not assigned. Abstract

172 NEUROSURGERY

Bagher-Ebadian H, Schwalb J, Mahmoudi F, Air E, Shokri S, Nazem-Zadeh M, Spanaki-Varelas M, Wasade V, and Soltanian-Zadeh H. Localized quantitative analysis of positron emission tomography (PET) for temporal lobe epilepsy lateralization and surgical intervention J Nucl Med 2016; 57PMID: Not assigned. Abstract

Boyce-Fappiano D, Elibe E, Lee IY, Rock J, Siddiqui MS, and Siddiqui F. Combined stereotactic radiosurgery and percutaneous vertebral augmentation for pain control in pathological vertebral compression fractures Int J Radiat Oncol Biol Phys 2016; 96(2s):E87. PMID: 27675486. Full Text Abstract

Boyce-Fappiano D, Elibe E, Lee IY, Rock J, Siddiqui MS, and Siddiqui F. Single-fraction stereotactic radiosurgery for renal cell carcinoma spine metastasis Int J Radiat Oncol Biol Phys 2016; 96(2s):E519. PMID: 27674908. Full Text Abstract

Cloughesy TF, Aghi MK, Chen C, Elder JB, Kesari S, Kalkanis SN, Kaptain G, Landolfi JC, Mikkelsen T, Portnow J, Robbins JM, Ostertag D, Das A, Chu A, and Vogelbaum MA. Encouraging survival with Toca 511 and Toca FC compared to external lomustine control J Clin Oncol 2016; 34PMID: Not assigned. Abstract

Cloughesy TF, Aghi M, Bota D, Chen C, Elder JB, Kalkanis SN, Kaptain GJ, Kesari S, Landolfi J, Mikkelsen T, Portnow J, Robbins JM, Ostertag D, Chu A, Huang T, and Vogelbaum MA. Prior radiation in subjects who were treated with toca 511 and toca fc across 3 toca 511 phase 1 trials Int J Radiat Oncol Biol Phys 2016; 96(2s):E66-e67. PMID: 27675287. Full Text Abstract

Elibe E, Boyce-Fappiano D, Walker EM, Lee IY, Rock J, Siddiqui S, and Siddiqui F. Significance of hormone therapy and bisphosphonate use on vertebral compression fracture (vcf) incidence following spine stereotactic body radiation therapy (sbrt) for breast cancer metastases Int J Radiat Oncol Biol Phys 2016; 96(2s):E509. PMID: 27674881. Full Text Abstract

Jolly DJ, Robbins JM, Ostertag D, Ibanez C, Kasahara N, Gruber H, Kalkanis SN, Vogelbaum M, Aghi MK, Cloughesy T, Chu A, Das A, and Skillings J. Ascending dose trials of a retroviral replicating vector (toca 511) in patients with recurrent high-grade glioma: Clinical update, molecular analyses, and proposed mechanism of action Mol Ther 2016; 24:S27-S27. PMID: Not assigned. Abstract

Mattour AH, Walbert T, Lee I, and Wang D. A revisit of the devastating outcome of leptomeningeal disease JClin Oncol 2016; 34PMID: Not assigned. Abstract

Munster PN, Mahlpal A, Nemunaitis JJ, Mlta MM, Paz-Ares LG, Massard C, Mikkelsen T, Cruz C, Rathkopf DE, Blumenschein GR, Hidalgo M, Smith DC, Eichhorst B, Cloughesy TF, Garrick B, Trowe T, Filvaroff E, Hege K, and Bendell JC. Phase I trial of a dual TOR kinase and DNA-PK inhibitor (CC- 115) in advanced solid and hematologic cancers J Clin Oncol 2016; 34PMID: Not assigned. Abstract

Nagaraja TN, Keenan KA, Ewing JR, and Knight RA. Surrogate MRI signatures for contrast enhanced imaging that predict acute blood-brain barrier damage in ischemia-reperfusion Stroke 2016; 47PMID: Not assigned. Abstract

Nakagawa P, Xu J, Bordcoch G, Janic B, and Carretero OA. Inhibition of neutrophil chemotaxis by N-acetyl-seryl- aspartyl-lysyl-proline and thymosin β4 FASEB Journal 2016; 30 PMID: Not assigned. Abstract

Snyder J, Scarpace L, Schultz L, and Walbert T. The role of neuro-oncology tumor boards at academic centers in the United States Neuro-Oncology 2016; 18:iv82. PMID: Not assigned. Abstract

173 Van Den Bent MJ, Gan HK, Lassman AB, Kumthekar P, Merrell R, Butowski NA, Lwin Z, Mikkelsen T, Nabors LB, Papadopoulos KP, Penas-Prado M, Simes J, Wheeler H, Gomez EJ, Lee HJ, Roberts- Rapp L, Xiong H, Bain EE, Holen KD, and Reardon DA. Efficacy of a novel antibody-drug conjugate (ADC), ABT-414, as monotherapy in epidermal growth factor receptor (EGFR) amplified, recurrent glioblastoma (GBM) J Clin Oncol 2016; 34PMID: Not assigned. Abstract

174 OBSTETRICS GYNECOLOGY AND WOMEN’S HEALTH SERVICES

Allo G, Chitale DA, Alford SH, Munkarah AR, Winer I, and Ratnam M. Glucocorticoid receptor expression in ovarian tumors Lab Invest 2016; 96:274A-274A. PMID: Not assigned. Abstract

Alrahmani L, Adekola H, and Awonuga A. Trauma in multi-fetal gestations Reprod Sci 2016; 23:111A-111A. PMID: Not assigned. Abstract

Aoun J, Shaw J, Eisenstein D, and Tsafrir Z. Long-term follow-up after surgical repair of occult hernia in women with unexplained chronic pelvic pain J Minim Invasive Gynecol 2016; 23(7):S237. PMID: Not assigned. Abstract

Aoun J, Shaw J, Eisenstein D, and Tsafrir Z. Diagnosis of occult hernia in women with unexplained chronic pelvic pain J Minim Invasive Gynecol 2016; 23(7):S15. PMID: Not assigned. Abstract

Eisenstein DI. Laparoscopic ultrasound during robotic myomectomy J Minim Invasive Gynecol 2016; 23(7):S118. PMID: Not assigned. Abstract

Ghanem AI, Khan N, Mahan M, Buekers T, and Elshaikh MA. Survival endpoints with or without lymphadenectomy in women with stage I endometrial carcinoma: A matched-pair analysis J Clin Oncol 2016; 34PMID: Not assigned. Abstract

Griffin M, Diaz-Insua M, ElShatanoufy S, and Atiemo H. Medical student robotic simulator performance does not correlate with their usmle scores Neurourol Urodyn 2016; 35:S14-S15. PMID: Not assigned. Abstract

Haley L, Buekers TE, Burmeister C, and Elshaikh MA. Older age is no longer an adverse prognostic factor in women with early-stage endometrial carcinoma: A matched analysis Gynecol Oncol 2016; 141:70-71. PMID: Not assigned. Abstract

Hijaz M, Das S, Mert I, Chhina J, Tebbe C, Dar S, Seal S, Munkarah AR, and Rattan R. Targeting ovarian cancer by folic acid conjugated nanoceria Gynecol Oncol 2016; 141:184-185. PMID: Not assigned. Abstract

Hijaz M, Jankowski J, and Sangha R. Factors affecting recurrence of leiomyomas in older women (above age 40) J Minim Invasive Gynecol 2016; 23(7):S13. PMID: Not assigned. Abstract

Hijaz M, Jankowski J, and Sangha R. Is race and BMI associated with leiomyoma recurrence in women above age 40? J Minim Invasive Gynecol 2016; 23(7):S241. PMID: Not assigned. Abstract

Hinshaw HD, Boggess JF, Kowalski LD, Scalici JM, Cantrell LA, Schuler KM, Hanna RK, Ivanova A, Matei D, and Rossi EC. The relationship between endometrial cancer sentinel lymph node micro and macro metastases and uterine pathology features Gynecol Oncol 2016; 141:30. PMID: Not assigned. Abstract

Isrow D, Burmeister C, Munkarah AR, and Elshaikh MA. Survival endpoints for young women with early-stage uterine endometrioid carcinoma: A matched analysis Gynecol Oncol 2016; 141:62. PMID: Not assigned. Abstract

Jaber S, Hensley Alford S, Munkarah AR, and Rasool N. Ovarian cancer in elderly women ≥ 70 years of age: Our clinical experience Gynecol Oncol 2016; 141:60-61. PMID: Not assigned. Abstract

Lee JK, Mahan M, Khan N, Hanna R, and Elshaikh MA. Survival outcomes in women with international federation of gynecology and obstetrics stage IIIC2 endometrial carcinoma Int J Radiat Oncol Biol Phys 2016; 96(2s):E308. PMID: 27674336. Full Text Abstract

Mert I, Munkarah AR, Hanna RK, Chhina J, Carey MS, Llaurado M, and Rattan R. Is it time to repurpose metformin for the treatment of low-grade ovarian cancer? Gynecol Oncol 2016; 141:55-56. PMID: Not assigned. Abstract 175

Modh A, Ghanem AI, Burmeister C, Rasool N, and Elshaikh MA. Trends in the utilization of adjuvant radiation treatment in women with early stage type ii endometrial carcinoma: A surveillance, epidemiology, and end-results study Brachytherapy 2016; 15:S89. PMID: Not assigned. Abstract

Munkarah AR, Kim S, Buekers TE, Chhina J, Poisson L, Giri S, and Rattan R. Metabolic effects of metformin treatment in ovarian cancer cell lines Gynecol Oncol 2016; 141:168. PMID: Not assigned. Abstract

Munkarah A, Hamid S, Chhina J, Mert I, Jackson L, Hensley-Alford S, Chitale D, Giri S, and Rattan R. Targeting of free fatty acid signaling in ovarian cancer may serve as a potential therapeutic approach Clin Cancer Res 2016; 22PMID: Not assigned. Abstract

Petersen S, Khangura R, and Sangha R. Chorangiosis: Clinical associations and obstetrical outcomes Obstet Gynecol 2016; 127:131S-132S. PMID: Not assigned. Abstract

Petersen S, Rubinfeld I, Buekers T, and Sangha R. Analysis of risk factors for urologic injuries after minimally invasive vs abdominal hysterectomy J Minim Invasive Gynecol 2016; 23(7):S29. PMID: Not assigned. Abstract

Petersen S, and Sangha R. Urinary tract fistula after minimally invasive hysterectomy: Presentation and outcomes J Minim Invasive Gynecol 2016; 23(7):S218. PMID: Not assigned. Abstract

Rattan R, Mert I, Chhina J, Hamid S, Hijaz M, Poisson L, Hensley Alford S, Giri S, and Munkarah AR. Targeting of free fatty acid receptor 1 in EOC: A novel strategy to restrict the adipocyte-EOC dependence Gynecol Oncol 2016; 141:47. PMID: Not assigned. Abstract

Sakr S, Abdulfatah E, Munkarah AR, Morris RT, Elshaikh MA, Pardeshi V, and Ali-Fehmi R. Prognostic value of loss of MMR protein expression in endometrial carcinoma in African American and White women Gynecol Oncol 2016; 141:112. PMID: Not assigned. Abstract

Sakr S, Giri S, Rattan R, Abdulfatah E, Pardeshi V, Morris RT, Munkarah AR, and Ali-Fehmi R. Expression of alcohol dehydrogenase 5 in ovarian carcinoma: Effect on prognosis and therapeutic potential Gynecol Oncol 2016; 141:67. PMID: Abstract

Sangha R, Bossick A, and Wegienka G. Use of focus groups to identify pre-and post-hysterectomy patient centered preferences J Minim Invasive Gynecol 2016; 23(7):S241. PMID: Not assigned. Abstract

Talukdar S, Underwood J, Atkinson S, and Sangha R. Who will suffer from postablation pelvic pain? A retrospective analysis of risk factors Obstet Gynecol 2016; 127:141S. PMID: Not assigned. Abstract

Taylor M, Mert I, Hijaz M, Chhina J, Morris RT, Giri S, Rattan R, and Munkarah AR. Effects of an olaparib and metformin combination on the AMPK and DNA-damage pathways in ovarian cancer Gynecol Oncol 2016; 141:197- 198. PMID: Not assigned. Abstract

Tran AM, Yang W, Boggess JF, Kowalski LD, Scalici JM, Cantrell LA, Schuler KM, Ivanova A, Hanna RK, and Rossi EC. Bilateral SLN mapping for cervical cancer with ICG and robotic fluorescence imaging is associated with greater accuracy in detecting metastatic disease Gynecol Oncol 2016; 141:21. PMID: Not assigned. Abstract

Underwood J, Chiu M, Park H, and Al-Wahab Z. Hair in all the wrong places: Ovarian steroid cell tumor, not otherwise specified: A case series Obstet Gynecol 2016; 127:137S-138S. PMID: Not assigned. Abstract

Winer IS, Patel D, Dalton V, Johnston C, Quint E, Zochowski M, Munkarah AR, Morris R, and Haefner H. The practice patterns and outlook of gynecology oncologists in the treatment of pediatric, adolescent and young adults with gynecologic malignancies: A survey study J Clin Oncol 2016; 34PMID: Not assigned. Abstract

176

Xu Y, Hanna RK, Burmeister C, Munkarah AR, and Elshaikh MA. Predictors of survival after recurrence inwomen with early-stage endometrial carcinoma Gynecol Oncol 2016; 141:70. PMID: Not assigned. Abstract

177

OPTHALMOLOGY AND EYE CARE SERVICES

Spaulding J, Saraf S, Essad K, and Christianson M. The first case of intracranial rosai dorfman disease Neurology 2016; 86(16)PMID: Not assigned. Abstract

ORTHOPAEDICS AND ATHLETIC MEDICINE

Gibson G, and Yang M. Gene editing in chondrocytes using crispr/cas9 Osteoarthritis and Cartilage 2016; 24:S2-S3. PMID: Not assigned. Abstract

Shehab R. 679 Clinical Case Slide Discussant - Upper Extremity - Shoulder Med Sci Sports Exerc 2016; 48(5 Suppl 1):179. PMID: 27359822. Abstract

178

OTOLARYNGOLOGY – HEAD AND NECK SURGERY

Al Feghali KA, Ghanem AI, Chang S, Ghanem T, Burmeister C, Keller C, and Siddiqui F. Smoking predicts for worse pathological features in oral cavity squamous cell carcinoma Int J Radiat Oncol Biol Phys 2016; 96(2s):E386. PMID: 27674550. Full Text Abstract

Chen KM, Datta I, Stephen JK, Chitale D, Divine G, and Worsham MJ. ER negative-specific differentially methylated genes identify master regulators to expose potential epigenetic drivers of aggressive disease Eur J Cancer 2016; 54:S48. PMID: Not assigned. Abstract

Diaz M, Chang S, and Singer M. Adherence to dietary indexes by diabetes and hypertension status among PLCO cancer screening trial participants Adv Nutr 2016; 7(1):38A. PMID: Not assigned. Abstract

Ghanem AI, Al Feghali KA, Chang S, Ghanem T, Burmeister C, and Siddiqui F. Clinicopathologic features and survival outcomes among young patients with squamous cell carcinoma of the oral cavity Int J Radiat Oncol Biol Phys 2016; 96(2s):E364. PMID: 27674490. Full Text Abstract

Jesse M, Goldstein E, Macaulay T, Rebhan N, Ho CX, Bebanic M, Shkokani L, Abouljoud M, Eshelman A, and Yoshida A. Racial disparities in cognitive and social requirements prior to listing for liver transplant Am J Transplant 2016; 16:517. PMID: Not assigned. Abstract

Jesse M, Goldstein E, Rebhan N, Ho CX, Macaulay T, Bebanic M, Shkokani L, Moonka D, Abouljoud M, and Yoshida A. Racial disparities in the evaluation for liver transplantation Am J Transplant 2016; 16:520-521. PMID: Not assigned. Abstract

Rebhan N, Bebanic M, Yoshida A, Macaulay T, Goldstein E, Ho CX, Eshelman A, Abouljoud M, Jesse M, and Rizzari M. Psychiatric characteristics of acute liver failure patients: Acetaminophen overdose versus other etiologies Am J Transplant 2016; 16:524. PMID: Not assigned. Abstract

Swegal W, and Chang S. Tumor board checklists affect pretreatment clinic referral patterns Int J Rad Onc Biol Phys 2016; 94(4):902-903. PMID: Not assigned. Abstract

Worsham MJ, Chen KM, Chitale D, Stephen JK, and Divine G. Differentially methylated miRNA methylomes of normal breast tissue from ER negative and ER positive breast cancer mimic their respective tumor phenotypes Can Res 2016; 76(4)PMID: Not assigned. Abstract

Worsham MJ, Chen KM, Datta I, Stephen JK, Chitale D, and Divine G. Epigenetically altered microRNAmediated pathway dysregulation in ER negative breast cancer Can Res 2016; 76(4)PMID: Not assigned. Abstract

Worsham MJ, Chen KM, Stephen JK, Datta I, and Divine G. Integrating epigenetics into personalized medicine Eur J Cancer 2016; 54:S44. PMID: Not assigned. Abstract

179 PATHOLOGY

Adwar W, Gadde R, Chitale DA, Allo G, Schultz D, Gaba AR, and Zhang ZY. Management of insufficient endometrial biopsy for women with abnormal uterine bleeding: To further investigate or reassure? Lab Invest 2016; 96:273A-273A. PMID: Not assigned. Abstract

Al Feghali KA, Ghanem AI, Chang S, Ghanem T, Burmeister C, Keller C, and Siddiqui F. Smoking predicts for worse pathological features in oral cavity squamous cell carcinoma Int J Radiat Oncol Biol Phys 2016; 96(2s):E386. PMID: 27674550. Full Text Abstract

Allo G, Chitale DA, Alford SH, Munkarah AR, Winer I, and Ratnam M. Glucocorticoid receptor expression in ovarian tumors Lab Invest 2016; 96:274A-274A. PMID: Not assigned. Abstract

Arias-Stella J, Kezlarian B, Favazza L, Schultz D, and Chitale DA. Programmed cell death ligand 1 (pd-l1) expression in estrogen receptor positive (er plus ) invasive breast cancers (bc): A pilot study of 148 cases Lab Invest 2016; 96:29A-29A. PMID: Not assigned. Abstract

Arias-Stella J, Shah AB, Gupta NS, and Williamson SR. Ck20 and p53 immunohistochemistry: Staining patterns and follow up in urinary bladder specimens with urothelial atypia Lab Invest 2016; 96:215A- 215A. PMID: Not assigned. Abstract

Calio A, Eble JN, Hes O, Martignoni G, Williamson SR, Brunelli M, Osunkoya AO, Wang LS, Comperat E, Wang MS, Zhang SB, Curless K, Post K, Chang HY, Baldridge LA, MacLennan G, Montironi R, Grignon DJ, and Cheng L. Distinct clinicopathological features in metanephric adenoma harboring BRAF mutation Lab Invest 2016; 96:220A-220A. PMID: Not assigned. Abstract

Chen KM, Datta I, Stephen JK, Chitale D, Divine G, and Worsham MJ. ER negative-specific differentially methylated genes identify master regulators to expose potential epigenetic drivers of aggressive disease Eur J Cancer 2016; 54:S48. PMID: Not assigned. Abstract

Chitale DA, Wozniak J, Main N, Varney R, Tuthill M, and Zarbo RJ. Image documented surgical pathology (ID-SP) to enhance patient safety - lean redesign of the value stream steps from gross examination to signout Lab Invest 2016; 96:493A-493A. PMID: Not assigned. Abstract

Gadde R, Barod R, Rogers CG, Gupta NS, and Williamson SR. The spectrum of oncocytic renal tumors from oncocytoma to eosinophilic variant chromophobe renal cell carcinoma - is there a need to sub-classify and what is the malignant potential? Lab Invest 2016; 96:231A-231A. PMID: Not assigned. Abstract

Gadde R, Gulati R, Inamdar KV, Michalowski S, and Menon M. Cytogenetic analysis is crucial in the early diagnosis of indolent t-cell prolymphocytic leukemia Lab Invest 2016; 96:345A-345A. PMID: Not assigned. Abstract

Gulavita P, Zhou M, Amin MB, Sirohi D, Garcia E, Dal Cin P, Williamson SR, and Hirsch M. Morphologic and molecular evaluation of thyroid-like follicular carcinoma of the kidney Lab Invest 2016; 96:235A-235A. PMID: Not assigned. Abstract

Jamal M, Williamson SR, Diaz-Insua M, Menon M, Stricker H, Peabody J, Rogers CG, and Gupta NS. Significance of percentage of gleason pattern 4 at needle biopsy in predicting final gleason score and correlation with pathologic outcomes at radical prostatectomy Lab Invest 2016; 96:240A-240A. PMID: Not assigned. Abstract

Jamal M, Williamson SR, Diaz-Insua M, Menon M, Stricker H, Peabody J, Rogers CG, and Gupta NS. Clinical significance of percentage of gleason pattern 4 in gleason score 7 prostate cancer at radical prostatectomy Lab Invest 2016; 96:240A-240A. PMID: Not assigned. Abstract

Jiang F, Cabrera Fernandez DF, Church J, Gulati R, Taylor A, Menon M, and Kuriakose P. Correlation between peripheral blood counts and day 14 bone marrow biopsy in acute myeloid leukemia during induction chemotherapy Blood 2015; 126(23):3. PMID: Not assigned. Abstract

180 Kezlarian B, Cheng L, Gupta NS, and Williamson SR. Vasitis nodosa and related lesions: A modern immunohistochemical staining profile with special emphasis on diagnostic dilemmas Lab Invest 2016; 96:242A-242A. PMID: Not assigned. Abstract

Kezlarian B, Favazza L, Arias-Stella J, Schultz D, and Chitale DA. Does tumor infiltrating lymphocyte (TIL) count influence oncotype DxTM recurrence score and magee equation scores? Lab Invest 2016; 96:49A-49A. PMID: Not assigned. Abstract

Kouba E, Simper N, Eble JN, Grignon DJ, Wang MS, Zhang SB, Wang LS, Martignoni G, Williamson SR, Brunelli M, Luchini C, Calio A, and Cheng L. High fidelity of driver chromosomal alterations among primary and metastatic renal cell carcinomas: Implications for disease evolution and treatment Lab Invest 2016; 96:243A-243A. PMID: Not assigned. Abstract

Lu ZC, Williamson SR, Diaz-Insua M, Stricker H, Menon M, and Gupta NS. Pathologic outcomes and biochemical recurrence (BCR) free survival in men younger than 45 years with prostate cancer (PCa) treated with robotic radical prostatectomy (RRP) Lab Invest 2016; 96:247A-247A. PMID: Not assigned. Abstract

MacLeod E, Bresler R, Kheradmand T, Skorupski S, Gerlach J, and Ho S. Determining the serologic equivalent of a relatively rare common allele DRB1 11:17 Hum Immunol 2016; 77:141. PMID: Not assigned. Abstract ∗ Moonka D, Nagai S, Gadde R, Datta L, Divine G, Abouljoud MS, and Salgia R. Effect of tumor necrosis from loco- regional therapy prior to liver transplantation on hepatocellular carcinoma recurrence after transplant Hepatology 2016; 63(1):640A-641A. PMID: Not assigned. Abstract

Moonka D, Shah V, Datta L, Gadde R, Divine G, Yoshida A, Jafri SM, and Salgia R. Degree of tumor necrosis from pre-transplant loco-regional therapy is associated with tumor free survival after liver transplantation Transplantation 2016; 100(7):S429. PMID: Not assigned. Abstract

Munkarah A, Hamid S, Chhina J, Mert I, Jackson L, Hensley-Alford S, Chitale D, Giri S, and Rattan R. Targeting of free fatty acid signaling in ovarian cancer may serve as a potential therapeutic approach Clin Cancer Res 2016; 22PMID: Not assigned. Abstract

Newman L, Jiagge E, Bensenhaver J, Jibril A, Awuah B, and Stark A. Comparative Analysis of Breast Cancer Phenotypes in African American, White American, and West Versus East African Patients: Correlation Between African Ancestry and Triple Negative Breast Cancer Annals of Surgical Oncology 2016; 23:S8-S8. PMID: Not assigned. Abstract

Newman LA, Jiagge E, Bensenhaver JM, Chitale D, Kleer C, Merajver S, Kyei I, Aitpillah F, Oppong J, Amankwaa- Frempong E, Adjei E, Wicha M, Awuah B, and Stark A. Comparative analysis of breast cancer phenotypes in African American, white American, and African patients-correlation between African ancestry and triple negative breast cancer Cancer Res 2016; 76(4)PMID: Not assigned. Abstract

Roquiz W, Pardeshi V, Hassan O, Abdulfatah E, Modh A, Salem N, Daaboul M, Schultz D, Elshaikh MA, Bandyopadhyay S, and Ali-Fehmi R. The impact of androgen receptor expression on endometrial carcinoma Lab Invest 2016; 96:306A-307A. PMID: Not assigned. Abstract

Saste AB, Jiang F, Arias-Stella J, Gamalski S, Peres E, Janakiraman N, and Farhan S. Emberger syndrome with concomitant GATA2, NPM1 and FLT3-ITD mutations in remission after allogeneic stem cell transplant Biol Blood Marrow Transplant 2016; 22(3):S208-S209. PMID: Not assigned. Abstract - Full Text

Saste AB, Gulati R, Kuriakose P, Inamdar K, Karner K, Carey J, and Menon M. Prognostic impact of aberrant t/NK cell marker expression in AML J Clin Oncol 2016; 34PMID: Not assigned. Abstract

Shah A, Gadde R, Arias-Stella J, Williamson SR, and Gupta NS. Radical prostatectomy outcomes of prostatic adenocarcinoma diagnosed after initial diagnosis of atypical glands on prostate needle biopsy 181 Lab Invest 2016; 96:261A-262A. PMID: Not assigned. Abstract

Tuthill JM. Analysis of the impact and value of a specimen tracking and routing system implementation for anatomic pathology Virchows Archiv 2016; 469:S192. PMID: Not assigned. Abstract

Tuthill JM. Immunohistochemistry and special stains automated instrument interfaces Virchows Archiv 2016; 469:S303. PMID: Not assigned. Abstract

Williamson SR, Chitale DA, Favazza L, Barod R, Rogers CG, Palanisamy N, and Gupta NS. Clear cell renal cell tumors with intact VHL and chromosome 3p: how many entities exist? Lab Invest 2016; 96:271A-271A. PMID: Not assigned. Abstract

Williamson SR, Gadde R, Trpkov K, Hirsch M, Srigley JR, Reuter VE, Cheng L, Kunju LP, Barod R, Rogers CG, Delahunt B, Hes O, Eble JN, Zhou M, McKenney JK, Martignoni G, Fleming S, Grignon DJ, Moch H, and Gupta NS. Diagnostic criteria for oncocytic renal neoplasms: A survey of specialist renal tumor pathologists Lab Invest 2016; 96:270A-270A. PMID: Not assigned. Abstract

Williamson SR, Grignon DJ, Favazza L, Gupta NS, Chitale DA, and Palanisamy N. Chromosome 6p amplification including the TFEB gene: a novel mechanism of renal cell carcinoma pathogenesis? Lab Invest 2016; 96:270A-271A. PMID: Not assigned. Abstract

Worsham MJ, Chen KM, Chitale D, Stephen JK, and Divine G. Differentially methylated miRNA methylomes of normal breast tissue from ER negative and ER positive breast cancer mimic their respective tumor phenotypes Can Res 2016; 76(4)PMID: Not assigned. Abstract

Worsham MJ, Chen KM, Datta I, Stephen JK, Chitale D, and Divine G. Epigenetically altered microRNAmediated pathway dysregulation in ER negative breast cancer Can Res 2016; 76(4)PMID: Not assigned. Abstract

Worsham MJ, Chen KM, Stephen JK, Datta I, and Divine G. Integrating epigenetics into personalized medicine Eur J Cancer 2016; 54:S44. PMID: Not assigned. Abstract

Zarbo RJ, Felicella M, and Gaba AR. Validation of placental preservation for pathologic examination using the tissueSAFE formalin-free vacuum-sealing system Lab Invest 2016; 96:527A-527A. PMID: Not assigned. Abstract

182 PHARMACY

Abrencillo R, Simoff M, Smoot T, Ray C, Aljasmi M, Jennings J, and Yessayan L. Diphenhydramine as an adjunct to conscious sedation in bronchoscopy Chest 2016; 150(4):980A. PMID: Not assigned. Abstract

Blum E, Thavarajah K, and Smith AL. Optimization of patient-specific inhaler regimens: A pharmacy-pulmonology collaborative pilot program in the ambulatory care setting Chest 2016; 150(4):635A. PMID: Not assigned. Abstract

Farha R, Usman M, Gandolfo C, Smith A, and Ouellette D. Potential protective effect of PPI in COPD Chest 2016; 150(4):833A. PMID: Not assigned. Abstract

Farhan S, Pelland D, Wautelet S, Neme K, Mikulandric N, Trapp MA, Szymanski S, Ruemenapp K, Peres E, and Janakiraman N. Impact of cytomegalovirus on early chimerism in patients with myeloid disorders undergoing stem cell transplantation using reduced toxicity ablative conditioning regimen Biol Blood Marrow Transplant 2016; 22(3):S318-S318. PMID: Not assigned. Abstract

Farhan SY, Divine G, Neme K, Pelland D, Wautelet S, Mikulandric N, Ruemenapp K, Peres E, and Janakiraman N. Cytomegalovirus and effect on early chimerism in patients with myeloid disorders undergoing stem cell transplantation using reduced toxicity ablative conditioning regimen Blood 2015; 126(23):3. PMID: Not assigned. Abstract

183 PUBLIC HEALTH SCIENCES

Affan M, Schultz L, Cerghet M, and Elias S. Clinical and radiological presentation of neurosarcoidosis: Single center cohort study of 107 cases (p6.114) Neurology 2016; 86(16 Supplement) PMID: Not assigned. Abstract

Al Feghali KA, Ghanem AI, Chang S, Ghanem T, Burmeister C, Keller C, and Siddiqui F. Smoking predicts for worse pathological features in oral cavity squamous cell carcinoma Int J Radiat Oncol Biol Phys 2016; 96(2s):E386. PMID: 27674550. Full Text Abstract

Allo G, Chitale DA, Alford SH, Munkarah AR, Winer I, and Ratnam M. Glucocorticoid receptor expression in ovarian tumors Lab Invest 2016; 96:274A-274A. PMID: Not assigned. Abstract

Bazzi M, Abdullah N, Karabon P, Chick J, and Dabaja AA. Trends in embryo transfer rate, multiple birth rate, and pregnancy rate in response to the american society of reproductive medicine's recommendation to limit embryotransfer Fertility and Sterility 2016; 106:e325. PMID: Not assigned. Abstract

Cajigal S, Peterson EL, Wells KE, Zoratti EM, Lanfear DE, Seibold M, Rajesh K, Burchard EG, and Williams LK. Asthma control test composite score may not be superior to assessments of rescue inhaler use for predicting severe asthma exacerbations J Allergy Clin Immunol 2016; 137(2):AB207. PMID: Not assigned. Abstract

Castillo JJ, Glezerman IG, Boklage SH, Lamerato LE, Chiodo JA, Tidwell BA, and Schulman KL. Incidence and prognostic importance of hyponatremia in a cohort of patients with breast cancer Cancer Res 2016; 76(4)PMID: Not assigned. Abstract

Castillo J, Glezerman I, Krasa H, Lamerato L, Chiodo J, Tidwell B, and Schulman K. Treatment of hyponatremia in lung cancer patients with moderate to severe hypervolemic or euvolemic hyponatremia Chest 2016; 150(4):694A. PMID: Not assigned. Abstract

Chen KM, Datta I, Stephen JK, Chitale D, Divine G, and Worsham MJ. ER negative-specific differentially methylated genes identify master regulators to expose potential epigenetic drivers of aggressive disease Eur J Cancer 2016; 54:S48. PMID: Not assigned. Abstract

Cheung WL, Chopp M, Zhang T, Zhang ZG, and Morris D. Irisin induces neurite outgrowth in primarycortical neurons Brain Injury 2016; 30(5-6):497-498. PMID: Not assigned. Abstract

Demos D, Divine G, Paone G, Borgi J, Morgan J, Allenspach L, Stagner L, and Nemeh H. Abo compatibility in lung transplantation J Heart Lung Transplant 2016; 35(4):S368. PMID: Not assigned. Abstract

Farhan SY, Divine G, Neme K, Pelland D, Wautelet S, Mikulandric N, Ruemenapp K, Peres E, and Janakiraman N. Cytomegalovirus and effect on early chimerism in patients with myeloid disorders undergoing stem cell transplantation using reduced toxicity ablative conditioning regimen Blood 2015; 126(23):3. PMID: Not assigned. Abstract.

Frendl D, Epstein M, Fouayzi H, Krajenta R, Rybicki B, and Sokoloff M. Impact of guidelines on prostate cancer screening in a population-based setting, 2000-2014: Preliminary results from the first AUA data grant J Urol 2016; 195(4):e543. PMID: Not assigned. Abstract

Ghanem AI, Khan N, Mahan M, Buekers T, and Elshaikh MA. Survival endpoints with or without lymphadenectomy in women with stage I endometrial carcinoma: A matched-pair analysis J Clin Oncol 2016; 34PMID: Not assigned. Abstract

Ghanem AI, Al Feghali KA, Chang S, Ghanem T, Burmeister C, and Siddiqui F. Clinicopathologic features and survival outcomes among young patients with squamous cell carcinoma of the oral cavity Int J Radiat Oncol Biol Phys 2016; 96(2s):E364. PMID: 27674490. Full Text Abstract 184 Greenlee H, Neugut AI, Falci L, Hillyer GC, Buono D, Roh JM, Ergas IJ, Kwan ML, Lee M, Tsai WY, Shi Z, Lamerato L, Mandelblatt JS, Kushi LH, and Hershman DL. Complementary and alternative medicine use and breast cancer chemotherapy initiation: The BQUAL study Cancer Research 2016; 76(4)PMID: Not assigned. Abstract

Haley L, Buekers TE, Burmeister C, and Elshaikh MA. Older age is no longer an adverse prognostic factor in women with early-stage endometrial carcinoma: A matched analysis Gynecol Oncol 2016; 141:70-71. PMID: Not assigned. Abstract

Haque R, Xu XQ, Yood MU, Cassidy-Bushrow AE, Van den Eeden SK, and Potosky AL. Cardiovascular disease risk and androgen deprivation therapy in patients with localized prostate cancer Pharmacoepidemiol Drug Saf 2015; 24:323-324. PMID: Not assigned. Abstract

Isrow D, Burmeister C, Munkarah AR, and Elshaikh MA. Survival endpoints for young women with early-stage uterine endometrioid carcinoma: A matched analysis Gynecol Oncol 2016; 141:62. PMID: Not assigned. Abstract

Jaber S, Hensley Alford S, Munkarah AR, and Rasool N. Ovarian cancer in elderly women ≥ 70 years of age: Our clinical experience Gynecol Oncol 2016; 141:60-61. PMID: Not assigned. Abstract

Jaehne AK, Rivers EP, Poissons LK, Chen Y, Gill J, Deledda J, and Suarez A. Plasma proteome in patients with vasopressor dependent septic shock Shock 2016; 45(6):131. PMID: Not assigned. Abstract

Jain T, Nowak R, Hudson M, Frisoli T, Jacobsen G, Tabaku M, and McCord J. Short and long- term prognostic utility of the heart score in patients presenting to the emergency department with undifferentiated chest pain JAm Coll Cardiol 2016; 67(13):513. PMID: Not assigned. Abstract

Jiang F, Cabrera Fernandez DF, Church J, Gulati R, Taylor A, Menon M, and Kuriakose P. Correlation between peripheral blood counts and day 14 bone marrow biopsy in acute myeloid leukemia during induction chemotherapy Blood 2015; 126(23):3. PMID: Not assigned. Abstract

King D, Silverstein JM, Munir KM, Roe ED, Fox JL, Kouznetsova M, and Lamerato LE. Capturing acromegaly diagnosis and treatment across four major hospital systems: Insights from the acromedic (acromegaly multi-site electronic data innovative consortium) database Endocrine Reviews 2016; 37(2)PMID: Not assigned. Abstract

Kumar N, Nakagawa P, Janic B, Romero CA, Worou ME, Peterson EL, Ongeri EE, Niyitegeka JMV, Rhaleb NE, and Carretero OA. The anti-inflammatory peptide AC-SDKP is released from thymosin β4 by meprin α and prolyl oligopeptidase FASEB Journal 2016; 30 PMID: Not assigned. Abstract

Lee JK, Mahan M, Khan N, Hanna R, and Elshaikh MA. Survival outcomes in women with international federation of gynecology and obstetrics stage IIIC2 endometrial carcinoma Int J Radiat Oncol Biol Phys 2016; 96(2s):E308. PMID: 27674336. Full Text Abstract

Levoska MA, Jansen R, Jacobsen G, Jahnke M, Hekman D, and Eide M. Decreasing pediatric skin biopsy rates of lesions that were pigmented in a large health system J Invest Dermatol 2016; 136(5):S36-S36. PMID: Not assigned. Abstract

Li C, Zhang Y, Levin AM, Chopp M, and Zhang ZG. Characterization of micrornas and their target proteins in distal axons of cortical neurons Stroke 2016; 47PMID: Not assigned. Abstract

Li J, Gordon S, Rupp L, Zhang T, Boscarino J, Trinacty C, Schmidt M, Moorman A, Holmberg S, and Lu M. Long- term fibrosis and viral level progression among treated and untreated patients with chronic hepatitis B J Hepatol 2016; 64(2):S371. PMID: Not assigned. Abstract

Lu M, Gordon SC, Li J, Rupp LB, Zhou Y, Moorman AC, Spradling P, Teshale EH, Boscarino JA, Daida Y, Schmidt MA, Trudeau S, and Holmberg SD. Hepatitis C complications: Prevalence 185 and disparities in a large US cohort 2006- 2014 Hepatology 2016; 63(1):95A-96A. PMID: Not assigned. Abstract

Lu M, Li J, Rupp LB, Boscarino JA, Raebel M, Schmidt MA, Haller IV, Daida Y, Rodriguez CV, Sahota A, VanWormer JJ, Romanelli RG, Vincent J, and Gordon SC. Prevalence of primary biliary cholangitis (PBC) in large US health care systems: Case ascertainment using electronic health records Hepatology 2016; 63(1):196A. PMID: Not assigned. Abstract

Luria CJ, Sitarik AR, Havstad S, Wegienka GR, Kim H, Zoratti EM, Joseph CLM, and Andrea Cassidy B. Association between asthma symptom scores and increased perceived stress and trait anxiety in asthmatic adolescents J Allergy Clin Immunol 2016; 137(2):AB11. PMID: Not assigned. Abstract

Maturu S, Dayyoub T, Schultz L, Snyder J, Wasade V, Elsayed M, Gaddam S, Mahmood N, Constantinou J, Barkley G, Spanaki-Varelas M, and Zillgitt A. Outcomes of genetic generalized epilepsy at acomprehensive epilepsy center Neurology 2016; 86(16)PMID: Not assigned. Abstract

Michaels AT, Radjef R, She RC, Liu B, Peterson E, Pinto Y, Williams K, Sabbah H, and Lanfear D. Improving risk prediction in heart failure: MAGGIC plus natriuretic peptides J Card Fail 2016; 22(8):S99- S99. PMID: Not assigned. Abstract

Michaels AT, Radjef R, She R, Peterson E, Liu B, and Lanfear DE. Predicting mortality at discharge following hospitalization for acute heart failure J Card Fail 2016; 22:S21-S22. PMID: Not assigned. Abstract

Modh A, Ghanem AI, Burmeister C, Rasool N, and Elshaikh MA. Trends in the utilization of adjuvant radiation treatment in women with early stage type ii endometrial carcinoma: A surveillance, epidemiology, and end-results study Brachytherapy 2016; 15:S89. PMID: Not assigned. Abstract

Moonka D, Nagai S, Divine G, and Salgia R. Influence of donor age and cold ischemia on recurrence of hepatocellular carcinoma after liver transplantation Transplantation 2016; 100(7):S427. PMID: Not assigned. Abstract

Moonka D, Nagai S, Gadde R, Datta L, Divine G, Abouljoud MS, and Salgia R. Effect of tumor necrosis from loco- regional therapy prior to liver transplantation on hepatocellular carcinoma recurrence after transplant Hepatology 2016; 63(1):640A-641A. PMID: Not assigned. Abstract

Moonka D, Shah V, Datta L, Gadde R, Divine G, Yoshida A, Jafri SM, and Salgia R. Degree of tumor necrosis from pre-transplant loco-regional therapy is associated with tumor free survival after liver transplantation Transplantation 2016; 100(7):S429. PMID: Not assigned. Abstract

Morris D, Chopp M, Cheung WL, Cui Y, Zhang T, Lu M, Zhang L, and Zhang ZG. Thymosin β4 for the treatment of sub-acute stroke in aged rats Stroke 2016; 47PMID: Not assigned. Abstract

Muller CC, McCord J, Michaels A, Nowak R, Giannitsis E, Body R, Christ M, Lindahl B, DeFilippi C, Christenson R, Bendig G, Jacobsen G, and Mueller C. Symptoms predictive of acute myocardial infarction in the troponin era: Analysis from the TRAPID-AMI study J Am Coll Cardiol 2016; 67(13):518. PMID: Not assigned. Abstract

Munkarah AR, Kim S, Buekers TE, Chhina J, Poisson L, Giri S, and Rattan R. Metabolic effects of metformin treatment in ovarian cancer cell lines Gynecol Oncol 2016; 141:168. PMID: Not assigned. Abstract

Munkarah A, Hamid S, Chhina J, Mert I, Jackson L, Hensley-Alford S, Chitale D, Giri S, and Rattan R. Targeting of free fatty acid signaling in ovarian cancer may serve as a potential therapeutic approach Clin Cancer Res 2016; 22PMID: Not assigned. Abstract

Radjef R, Michaels A, Peterson E, She R, Liu B, Williams K, Sabbah H, and Lanfear D. 186 Performance of MAGGIC score in african americans compared to whites J Card Fail 2016; 22(8):S101- S101. PMID: Not assigned. Abstract

Rattan R, Mert I, Chhina J, Hamid S, Hijaz M, Poisson L, Hensley Alford S, Giri S, and Munkarah AR. Targeting of free fatty acid receptor 1 in EOC: A novel strategy to restrict the adipocyte-EOC dependence Gynecol Oncol 2016; 141:47. PMID: Not assigned. Abstract

Raymond T, Mawri S, Jacobsen G, Selektor Y, Velez M, Williams C, Nemeh H, Borgi J, Morgan J, Lanfear D, and Tita C. The incidence of spontaneous intracranial hemorrhage is associated with infection in patients with mechanical circulatory support J Heart Lung Transplant 2016; 35(4):S246. PMID: Not assigned. Abstract

Salafia CM, Thomas DM, Roberts DJ, and Straughen JK. Human placental pathology-diagnosis in the 21st century: New approaches and techniques Birth Defects Research Part a-Clinical and Molecular Teratology 2016; 106(5):370-370. PMID: Not assigned. Abstract

Sangha R, Bossick A, and Wegienka G. Use of focus groups to identify pre-and post- hysterectomy patient centered preferences J Minim Invasive Gynecol 2016; 23(7):S241. PMID: Not assigned. Abstract

Sareen N, Mariychina A, Hector C, Mahan M, and Ananthasubramaniam K. Do right ventricular diastolic tissue doppler parameters add diagnostic value in pulmonary hypertension? J Am Soc Echocardiogr 2016; 29(6):B101. PMID: Not assigned. Abstract

Snyder J, Scarpace L, Schultz L, and Walbert T. The role of neuro-oncology tumor boards at academic centers in the United States Neuro-Oncology 2016; 18:iv82. PMID: Not assigned. Abstract

Spradling PR, Xing J, Rupp LB, Moorman AC, Gordon SC, Lu M, Teshale EH, Boscarino JA, Daida Y, Schmidt MA, and Holmberg SD. Uptake of and factors associated with direct-acting antiviral therapy among patients infected with hepatitis C virus in the chronic hepatitis cohort study, 2014-2015 Hepatology 2016; 63(1):10A-11A. PMID: Not assigned. Abstract

Spradling PR, Xing J, Rupp LB, Moorman AC, Gordon SC, Lu M, Teshale EH, Boscarino JA, Daida Y, Schmidt MA, and Holmberg SD. Preliminary clinical outcome data among patients with hepatitis C virus infection receiving direct- acting antiviral therapy in the Chronic Hepatitis Cohort Study, 2014- 2015 Hepatology 2016; 63(1):487A-488A. PMID: Not assigned. Abstract

Teshale EH, Zhong Y, Moorman AC, Spradling PR, Holmberg SD, Rupp LB, Lu M, Gordon SC, Boscarino JA, Daida Y, and Schmidt MA. Alcohol use disorder among chronic hepatitis C patients: Prevalence and treatment outcome, CHeCS, 2006-2013 Hepatology 2016; 63(1):873A- 874A. PMID: Not assigned. Abstract

Vance S, Al Feghali KA, Taylor A, Kaur M, Neslund-Dudas C, Chetty IJ, Simoff M, Ajlouni M, and Movsas B. Do race and income influence quality of life (QOL) or survival outcomes after lung stereotactic body radiation therapy (SBRT)? a prospective study Int J Radiat Oncol Biol Phys 2016; 96(2s):E534. PMID: 27674948. Full Text Abstract

Wells KE, Kim H, Havstad S, and Woodcroft KJ. Trends in asthma-related pharmacy fills Pharmacoepidemiol Drug Saf 2015; 24:139-140. PMID: Not assigned. Abstract

Worsham MJ, Chen KM, Chitale D, Stephen JK, and Divine G. Differentially methylated miRNA methylomes of normal breast tissue from ER negative and ER positive breast cancer mimic their respective tumor phenotypes Can Res 2016; 76(4)PMID: Not assigned. Abstract

Worsham MJ, Chen KM, Datta I, Stephen JK, Chitale D, and Divine G. Epigenetically altered microRNAmediated pathway dysregulation in ER negative breast cancer Can Res 2016; 76(4)PMID: Not assigned. Abstract

Worsham MJ, Chen KM, Stephen JK, Datta I, and Divine G. Integrating epigenetics into personalized 187 medicine Eur J Cancer 2016; 54:S44. PMID: Not assigned. Abstract

Xu Y, Hanna RK, Burmeister C, Munkarah AR, and Elshaikh MA. Predictors of survival after recurrence inwomen with early-stage endometrial carcinoma Gynecol Oncol 2016; 141:70. PMID: Not assigned. Abstract

Xuereb L, Kaur B, Akrawe S, Nemeh HW, Borgi J, Lanfear DE, Williams CT, Paone G, and Morgan JA. Does preoperative atrial fibrillation increase the incidence of thromboembolic complications in patients supported with long- term LVADs? J Heart Lung Transplant 2016; 35(4):S130-S131. PMID: Not assigned. Abstract

Xuereb L, Kaur B, Akrawe S, Rashty J, Nemeh HW, Borgi J, Lanfear DE, Williams CT, Paone G, and Morgan JA. Reoperation for bleeding does not adversely impact long-term outcomes in LVAD recipients J Heart Lung Transplant 2016; 35(4):S249. PMID: Not assigned. Abstract

Xuereb L, Kaur B, Akrawe S, Rashty J, Nemeh HW, Borgi J, Tita C, Selektor Y, Velez M, Lanfear DE, Williams CT, Paone G, and Morgan JA. Drive line infections are not associated with an increased incidence of thromboembolic complications in patients on continuous flow LVAD support J Heart Lung Transplant 2016; 35(4):S246. PMID: Not assigned. Abstract

Yadav P, Eng M, Divine G, Wang DD, Arjomand-Fard H, Wyman J, Isley M, Borgi J, Paone G, Greenbaum A, and O'Neill W. Outcomes of impella assisted percutaneous balloon aortic valvuloplasty in very high risk severe aortic stenosis patients J Am Coll Cardiol 2016; 67(13):404. PMID: Not assigned. Abstract

Yin C, Weiland M, Li J, She R, Zhou L, and Mi Q. Serum miRNAs as potential biomarkers for early prediction of type 1 diabetes FASEB Journal 2016; 30PMID: Not assigned. Abstract

188 RADIATION ONCOLOGY

Al Feghali KA, Ghanem AI, Chang S, Ghanem T, Burmeister C, Keller C, and Siddiqui F. Smoking predicts for worse pathological features in oral cavity squamous cell carcinoma Int J Radiat Oncol Biol Phys 2016; 96(2s):E386. PMID: 27674550. Full Text Abstract

Al Feghali KA, Kolozsvary A, Lapanowski K, Isrow D, Brown SL, and Kim JH. A novel mechanism of radiosensitization by metformin Int J Radiat Oncol Biol Phys 2016; 96(2s):E574. PMID: 27675054. Full Text Abstract

Awan MJ, Zakem SJ, Ward MC, Machtay M, Riaz N, Caudell JJ, Dunlap NE, Isrow D, Dault J, Higgins KA, Beitler JJ, Siddiqui F, Trotti A, Lee N, Koyfman S, Heron DE, and Yao M. Reirradiation outcomes after upfront larynx preservation or total laryngectomy: A multi-institutional analysis Int J Radiat Oncol Biol Phys 2016; 96(2s):E376. PMID: 27674522. Full Text Abstract

Bagher-Ebadian H, Schwalb J, Mahmoudi F, Air E, Shokri S, Nazem-Zadeh M, Spanaki-Varelas M, Wasade V, and Soltanian-Zadeh H. Localized quantitative analysis of positron emission tomography (PET) for temporal lobe epilepsy lateralization and surgical intervention J Nucl Med 2016; 57PMID: Not assigned. Abstract

Bagher-Ebadian H, Siddiqui F, Liu C, Movsas B, and Chetty IJ. Prediction of response to radiation therapy treatment of head and neck cancers using an artificial neural network developed from cone beam computed tomography image textural information Int J Radiat Oncol Biol Phys 2016; 96(2s):S98. PMID: 27676067. Full Text Abstract

Barton KN, Bellon M, Crosby S, McEveney M, and Elshaikh M. Quantification & dosimetric consequences of air gaps surrounding vaginal cylinders in women undergoing vaginal HDR brachytherapy. Final report of a prospective study Brachytherapy 2016; 15:S125-S126. PMID: Not assigned. Abstract

Boyce-Fappiano D, Elibe E, Lee IY, Rock J, Siddiqui MS, and Siddiqui F. Combined stereotactic radiosurgery and percutaneous vertebral augmentation for pain control in pathological vertebral compression fractures Int J Radiat Oncol Biol Phys 2016; 96(2s):E87. PMID: 27675486. Full Text Abstract

Boyce-Fappiano D, Elibe E, Lee IY, Rock J, Siddiqui MS, and Siddiqui F. Single-fraction stereotactic radiosurgery for renal cell carcinoma spine metastasis Int J Radiat Oncol Biol Phys 2016; 96(2s):E519. PMID: 27674908. Full Text Abstract

Brown SL, Elmghirbi R, Nagaraja T, Keenan KA, Lapanowski K, Panda S, Inder P, Cabral G, Liu L, Kim JH, Movsas B, Chetty IJ, Ewing JR, and Parry R. Toward a noninvasive measurement of cancer stem cells and tumor aggressiveness Int J Radiat Oncol Biol Phys 2016; 96(2s):E592. PMID: 27675105. Full Text Abstract

Caudell JJ, Ward MC, Koyfman S, Riaz N, Dunlap NE, Isrow D, Zakem SJ, Awan MJ, Vargo J, Heron DE, Higgins KA, Beitler JJ, Yao M, Machtay M, Trotti A, Siddiqui F, and Lee N. Multi-institution analysis of intensity modulated radiation therapy-based reirradiation for head and neck cancer: Improved risk- benefit profile in the modern era Int J Radiat Oncol Biol Phys 2016; 96(2s):S115-s116. PMID: 27675560. Full Text Abstract

Dehkordi AN, Kamali-Asl A, Ewing JR, and Bagher-Ebadian H. An adaptive model for direct estimation of extravascular-extracellular space in dynamic contrast-enhanced magnetic resonance imaging studies Int J Radiat Oncol Biol Phys 2016; 96(2s):E644. PMID: 27675247. Full Text Abstract

Elibe E, Boyce-Fappiano D, Walker EM, Lee IY, Rock J, Siddiqui S, and Siddiqui F. Significance of hormone therapy and bisphosphonate use on vertebral compression fracture (vcf) incidence following spine stereotactic body radiation therapy (sbrt) for breast cancer metastases Int J Radiat Oncol Biol Phys 2016; 96(2s):E509. PMID: 27674881. Full Text Abstract

189 Feng M, Matuszak MM, Boike TP, Grills IS, Kestin LL, Movsas B, Paximadis PA, Griffith KA, Gustafson GS, Moran JM, Nurushev TS, Radawski JD, Pierce LJ, Hayman JA, and Schipper M. Predictors of heart dose from lung radiation therapy in a large consortium of community and academic practices Int J Radiat Oncol Biol Phys 2016; 96(2s):E482. PMID: 27674809. Full Text Abstract

Freytag SO, Movsas B, and Stricker H. Clinical trials of oncolytic adenovirus-mediated gene therapy Mol Ther 2016; 24:S205-S205. PMID: Not assigned. Abstract

Ghanem AI, Khan N, Mahan M, Buekers T, and Elshaikh MA. Survival endpoints with or without lymphadenectomy in women with stage I endometrial carcinoma: A matched-pair analysis J Clin Oncol 2016; 34PMID: Not assigned. Abstract

Ghanem AI, Al Feghali KA, Chang S, Ghanem T, Burmeister C, and Siddiqui F. Clinicopathologic features and survival outcomes among young patients with squamous cell carcinoma of the oral cavity Int J Radiat Oncol Biol Phys 2016; 96(2s):E364. PMID: 27674490. Full Text Abstract

Glide-Hurst CK, Miller BM, Kim JP, Siddiqui MS, and Movsas B. Potential failure modes for magnetic resonance- only treatment planning in the pelvis Int J Radiat Oncol Biol Phys 2016; 96(2s):S233-s234. PMID: 27675862. Full Text Abstract

Glide-Hurst C, Price R, Kim JP, Zheng W, and Chetty IJ. Validation of synthetic CTs for MR-only planning of brain cancer Radiother Oncol 2016; 119:S870. PMID: Not assigned. Abstract

Haley L, Buekers TE, Burmeister C, and Elshaikh MA. Older age is no longer an adverse prognostic factor in women with early-stage endometrial carcinoma: A matched analysis Gynecol Oncol 2016; 141:70-71. PMID: Not assigned. Abstract

Isrow D, Burmeister C, Munkarah AR, and Elshaikh MA. Survival endpoints for young women with early-stage uterine endometrioid carcinoma: A matched analysis Gynecol Oncol 2016; 141:62. PMID: Not assigned. Abstract

Isrow D, Kolozsvary A, Lapanowski K, Brown SL, and Kim JH. Metformin's preferential cytotoxic effect on cancer stem/non-stem cell populations is (glucose) dependent and correlated with intracellular levels of reactive oxygen species Int J Radiat Oncol Biol Phys 2016; 96(2s):E565. PMID: 27675029. Full Text Abstract

Jagsi R, Griffith KA, Moran JM, Matuszak MM, Feng M, Marsh R, Boike TP, Grills IS, Gustafson GS, Heimburger DK, Nurushev TS, Radawski JD, Walker EM, Hayman JA, and Pierce LJ. Comparative effectiveness analysis of 3DCRT versus intensity modulated radiation therapy in a prospective multicenter cohort of breast cancer patients Int J Radiat Oncol Biol Phys 2016; 96(2s):S207. PMID: 27675795. Full Text Abstract

Karam I, Yao M, Heron DE, Poon I, Koyfman S, Yom SS, Siddiqui F, Lartigau E, Cengiz M, Yamazaki H, Hara W, Phan J, Vargo J, Lee VH, Foote RL, Harter KW, Lee N, Sahgal A, and Lo SS. Consensus statement from the international stereotactic body radiotherapy consortium for head and neck carcinoma-technical factors Int J Radiat Oncol Biol Phys 2016; 96(2s):E382-e383. PMID: 27674541. Full Text Abstract

Karam I, Yao M, Heron DE, Poon I, Koyfman S, Yom SS, Siddiqui F, Lartigau E, Cengiz M, Yamazaki H, Hara W, Phan J, Vargo J, Lee VH, Foote RL, Harter KW, Lee N, Sahgal A, and Lo SS. Consensus statement from the international stereotactic body radiotherapy consortium for head and neck carcinoma-patient selection and pre- and post-stereotactic body radiation therapy evaluation Int J Radiat Oncol Biol Phys 2016; 96(2s):E364-e365. PMID: 27674489. Full Text Abstract

Kumar N, Nakagawa P, Janic B, Romero CA, Worou ME, Peterson EL, Ongeri EE, Niyitegeka JMV, Rhaleb NE, and Carretero OA. The anti-inflammatory peptide AC-SDKP is released from thymosin β4 by meprin α and prolyl oligopeptidase FASEB Journal 2016; 30 PMID: Not assigned. Abstract 190 Lee JK, Mahan M, Khan N, Hanna R, and Elshaikh MA. Survival outcomes in women with international federation of gynecology and obstetrics stage IIIC2 endometrial carcinoma Int J Radiat Oncol Biol Phys 2016; 96(2s):E308. PMID: 27674336. Full Text Abstract

Mahmoud OM, Gabel M, Jhawar S, Gibbon D, Cracchiolo B, Leiser A, Isani S, Khan AJ, and Elshaikh MA. How important is chemotherapy timing and treatment duration in the adjuvant management of cervical cancer? Int J Radiat Oncol Biol Phys 2016; 96(2s):E290. PMID: 27674287. Full Text Abstract

Mahmoud OM, Green WR, Gabel M, Gibbon D, Leiser A, Isani S, Cracchiolo B, Khan AJ, and Elshaikh MA. Replicating landoni's study in the era of chemotherapy: Postoperative or radical concurrent chemoradiation therapy in early-stage cervical cancer? Int J Radiat Oncol Biol Phys 2016; 96(2s):E300. PMID: 27674314. Full Text Abstract

Mayadev JS, Elshaikh MA, Christie A, Nagel C, Khan N, Kennedy V, Lea J, Ghanem A, Miller DS, Xie XJ, Folkert M, and Albuquerque KV. Prognostic significance of nodal location in stage IIIC endometrial carcinoma: Implications for optimal adjuvant therapy Int J Radiat Oncol Biol Phys 2016; 96(2s):E303. PMID: 27674322. Full Text Abstract

Modh A, Ghanem AI, Burmeister C, Rasool N, and Elshaikh MA. Trends in the utilization of adjuvant radiation treatment in women with early stage type ii endometrial carcinoma: A surveillance, epidemiology, and end-results study Brachytherapy 2016; 15:S89. PMID: Not assigned. Abstract

Modh A, McHargue CA, Lim H, and Siddiqui F. Single-fraction radiation therapy provides highly effective palliation for cutaneous t-cell lymphoma Int J Radiat Oncol Biol Phys 2016; 96(2s):E492. PMID: 27674835. Full Text Abstract

Nakagawa P, Xu J, Bordcoch G, Janic B, and Carretero OA. Inhibition of neutrophil chemotaxis by N-acetyl-seryl- aspartyl-lysyl-proline and thymosin β4 FASEB Journal 2016; 30 PMID: Not assigned. Abstract

Paximadis PA, Schipper M, Matuszak MM, Feng M, Boike TP, Grills IS, Kestin L, Movsas B, Griffith KA, Gustafson GS, Moran JM, Nurushev TS, Radawski JD, Pierce LJ, and Hayman JA. Dosimetric variables predicting for acute esophagitis during definitive radiation therapy for locally advanced non- small cell lung cancer-results of a large prospective observational study Int J Radiat Oncol Biol Phys 2016; 96(2s):E447-e448. PMID: 27674717. Full Text Abstract

Roquiz W, Pardeshi V, Hassan O, Abdulfatah E, Modh A, Salem N, Daaboul M, Schultz D, Elshaikh MA, Bandyopadhyay S, and Ali-Fehmi R. The impact of androgen receptor expression on endometrial carcinoma Lab Invest 2016; 96:306A-307A. PMID: Not assigned. Abstract

Sakr S, Abdulfatah E, Munkarah AR, Morris RT, Elshaikh MA, Pardeshi V, and Ali-Fehmi R. Prognostic value of loss of MMR protein expression in endometrial carcinoma in African American and White women Gynecol Oncol 2016; 141:112. PMID: Not assigned. Abstract

Stinchcombe T, Zhang YJ, Vokes EE, Schiller JH, Bradley JD, Curran WJ, Movsas B, Schild SE, Clamon GH, Govindan R, Blumenschein GR, Socinski MA, Ready N, Akerley WL, Cohen HJ, Pang H, and Wang XF. A pooled analysis of concurrent chemoradiotherapy (CCRT) for patients with stage III non-small cell lung cancer (NSCLC) who participated in U.S. cooperative group trials: Comparing the outcomes of elderly to younger patients (pts) J Clin Oncol 2016; 34PMID: Not assigned. Abstract

Vance S, Al Feghali KA, Taylor A, Kaur M, Neslund-Dudas C, Chetty IJ, Simoff M, Ajlouni M, and Movsas B. Do race and income influence quality of life (QOL) or survival outcomes after lung stereotactic body radiation therapy (SBRT)? a prospective study Int J Radiat Oncol Biol Phys 2016; 96(2s):E534. PMID: 27674948. Full Text Abstract

Vargo J, Ward MC, Caudell JJ, Riaz N, Dunlap NE, Isrow D, Zakem SJ, Dault J, Awan MJ, Higgins KA, Beitler JJ, Yao M, Machtay M, Siddiqui F, Trotti A, Lee N, Koyfman S, and Heron DE. Optimal treatment selection of stereotactic body radiation therapy and intensity modulated radiation therapy for reirradiation of head and neck cancer: A multi-institution comparison Int J Radiat Oncol Biol Phys 191 2016; 96(2s):S114-s115. PMID: 27675558. Full Text Abstract

Ward MC, Riaz N, Caudell JJ, Dunlap NE, Isrow D, Zakem SJ, Dault J, Awan MJ, Vargo J, Heron DE, Higgins KA, Beitler JJ, Yao M, Machtay M, Siddiqui F, Trotti A, Lee N, and Koyfman S. Multi- institution analysis of intensity modulated radiation therapy-based reirradiation for head and neck cancer: Prognostic factors and recursive partitioning analysis for overall survival Int J Radiat Oncol Biol Phys 2016; 96(2s):S115. PMID: 27675561. Full Text Abstract

Watkins Bruner D, Pugh SL, Lee WR, Dignam JJ, Low D, Swanson GP, Shah AB, D'Souza DP, Michalski JM, Dayes IS, Seaward SA, Nguyen PL, Hall WA, Pisansky TM, Chen Y, Sandler HM, and Movsas B. NRG oncology/RTOG 0415, phase 3 noninferiority study comparing 2 fractionation schedules in patients with low-risk prostate cancer: prostate-specific quality of life results Int J Radiat Oncol Biol Phys 2016; 96(2s):S2-s3. PMID: 27675773. Full Text Abstract

Wen N, Bagher-Ebadian H, Pantelic M, Hearshen D, Elshaikh MA, Chetty IJ, and Movsas B. A physiologically nested pharmacokinetic model in dynamic contrast-enhanced magnetic resonance imaging for detection of dominant intraprostatic lesions in patients with prostate cancer Int J Radiat Oncol Biol Phys 2016; 96(2s):E619. PMID: 27675180. Full Text Abstract

Wu Q, Wen N, Snyder KC, Liu C, Huang Y, Zhao B, Chetty IJ, Shah MM, Movsas B, and Siddiqui S. The projection summing optimization algorithm can effectively reduce normal brain dose in stereotactic radiosurgery of multiple brain metastases with single isocenter Int J Radiat Oncol Biol Phys 2016; 96(2s):E676-e677. PMID: 27675330. Full Text Abstract

Xu Y, Hanna RK, Burmeister C, Munkarah AR, and Elshaikh MA. Predictors of survival after recurrence inwomen with early-stage endometrial carcinoma Gynecol Oncol 2016; 141:70. PMID: Not assigned. Abstract

192 RESEARCH ADMINISTRATION

Cytogenetics

Gadde R, Gulati R, Inamdar KV, Michalowski S, and Menon M. Cytogenetic analysis is crucial in the early diagnosis of indolent t-cell prolymphocytic leukemia Lab Invest 2016; 96:345A-345A. PMID: Not assigned. Abstract

Image Analysis Program

Bagher-Ebadian H, Schwalb J, Mahmoudi F, Air E, Shokri S, Nazem-Zadeh M, Spanaki-Varelas M, Wasade V, and Soltanian-Zadeh H. Localized quantitative analysis of positron emission tomography (PET) for temporal lobe epilepsy lateralization and surgical intervention J Nucl Med 2016; 57PMID: Not assigned. Abstract

193 SURGERY

Bryce K, Tita C, Williams C, Morgan J, Nemeh H, Selektor Y, Borgi J, Velez M, and Lanfear D. Cognitive functioning is associated with clinical outcomes after LVAD implantation J Am Coll Cardiol 2016; 67(13):1273. PMID: Not assigned. Abstract

Carlyle L, Wang DD, Taylor A, Swanson B, Wyman J, Pantelic M, Song T, Eng M, Paone G, Greenbaum A, and O'Neill W. No two systoles the same: Personalizing transcatheter heart valve selection for transcatheter aortic valve replacement J Am Coll Cardiol 2016; 67(13):327. PMID: Not assigned. Abstract

Davis FM, Horne D, Grey SF, Mansour A, Nypaver T, Grossman P, Gurm H, and Henke P. Surgical site infection: Incidence, prediction, and risk factors following open lower extremity bypass surgery J Vasc Surg 2016; 64(3):870- 870. PMID: Not assigned. Abstract

Demos D, Divine G, Paone G, Borgi J, Morgan J, Allenspach L, Stagner L, and Nemeh H. Abo compatibility in lung transplantation J Heart Lung Transplant 2016; 35(4):S368. PMID: Not assigned. Abstract

Eng MH, Greenbaum A, Wang DD, Wyman J, Nemeh H, Paone G, and O'Neill W. Transseptal delivery for mitral valve in valve procedures using an apical rail: Technique description and initial results J Am Coll Cardiol 2016; 67(13):335. PMID: Not assigned. Abstract

Gupta RC, Sing-Gupta V, Palaniyandi S, and Sabbah HN. Reduced aldehyde dehydrogenase-2 activity and protein level in left ventricular myocardium of dogs with chronic heart failure J Am Coll Cardiol 2016; 67(13):1498. PMID: Not assigned. Abstract

Hans S, and Catanescu I. Results of early versus delayed carotid endarterectomy after a recent mild to moderate stroke J Vasc Surg 2016; 64(3):879-880. PMID: Not assigned. Abstract

Jesse M, Abouljoud M, Eshelman A, DeReyck C, and Lerut J. American and european transplant surgeons: Research, teaching, and burnout Am J Transplant 2016; 16:790. PMID: Not assigned. Abstract

Jesse M, Goldstein E, Macaulay T, Rebhan N, Ho CX, Bebanic M, Shkokani L, Abouljoud M, Eshelman A, and Yoshida A. Racial disparities in cognitive and social requirements prior to listing for liver transplant Am J Transplant 2016; 16:517. PMID: Not assigned. Abstract

Jesse M, Goldstein E, Rebhan N, Ho CX, Macaulay T, Bebanic M, Shkokani L, Moonka D, Abouljoud M, and Yoshida A. Racial disparities in the evaluation for liver transplantation Am J Transplant 2016; 16:520-521. PMID: Not assigned. Abstract

Kavousi Y, Crutchfield JM, Swanson C, Karamanos E, and Lin JC. Use of telemedicine for management of patients with varicose vein disease J Vasc Surg 2016; 64(3):863-864. PMID: Not assigned. Abstract

Moonka D, Nagai S, Divine G, and Salgia R. Influence of donor age and cold ischemia on recurrence of hepatocellular carcinoma after liver transplantation Transplantation 2016; 100(7):S427. PMID: Not assigned. Abstract

Moonka D, Nagai S, Gadde R, Datta L, Divine G, Abouljoud MS, and Salgia R. Effect of tumor necrosis from loco- regional therapy prior to liver transplantation on hepatocellular carcinoma recurrence after transplant Hepatology 2016; 63(1):640A-641A. PMID: Not assigned. Abstract

Moonka D, Shah V, Datta L, Gadde R, Divine G, Yoshida A, Jafri SM, and Salgia R. Degree of tumor necrosis from pre-transplant loco-regional therapy is associated with tumor free survival after liver transplantation Transplantation 2016; 100(7):S429. PMID: Not assigned. Abstract

194 Nagai S, Yoshida A, Rizzari M, Collins K, Kim D, and Abouljoud M. Center and surgeons' experience improves outcome in adult-to-adult living donor liver transplantation: Validation of the report of the A2ALL consortium Am J Transplant 2016; 16:475. PMID: Not assigned. Abstract

Nagai S, Yoshida A, Rizzari M, Collins K, Kim D, and Abouljoud M. Updated experience of living donor right hepatectomy using mini-incision technique Am J Transplant 2016; 16:475. PMID: Not assigned. Abstract

O'Connell PJ, Busque S, Vincenti F, Tedesco Silva H, Yoshida A, Friedewald JJ, Steinberg SJ, Budde K, Broeders EN, Kim YS, Hahn C, Li H, and Chan G. Tofacitinib in renal allograft recipients: Long-term efficacy and safety in an active-comparator-controlled extension trial Transplantation 2016; 100(7):S84-S85. PMID: Not assigned. Abstract

Onders R, Carlin A, Dunkin B, Jossart G, Marohn M, Menegaux F, Morton J, and Smith CD. Multi- center analysis of operative safety of surgery in patients with amyotrophic lateral sclerosis: The diaphragm pacing experience Surg Endosc 2016; 30:S317. PMID: Not assigned. Abstract

Park K, Rosso K, and Nathanson S. Translating a 2-d mammogram into a 3-d breast in the operating room Ann Surg Oncol 2016; 23:S48-S48. PMID: Not assigned. Abstract

Petersen S, Rubinfeld I, Buekers T, and Sangha R. Analysis of risk factors for urologic injuries after minimally invasive vs abdominal hysterectomy J Minim Invasive Gynecol 2016; 23(7):S29. PMID: Not assigned. Abstract

Putchakayala K, Kane W, Takahashi K, Rizzari M, Yoshida A, and Abouljoud M. Left renal vein ligation for management of portal hypoperfusion in liver transplantation Am J Transplant 2016; 16:672. PMID: Not assigned. Abstract

Rao B, Yoshida A, Ibrahim M, and Jafri SM. The use of perioperative lactate values as markers for adverse outcomes in liver transplantation Am J Transplant 2016; 16:672. PMID: Not assigned. Abstract

Raymond T, Mawri S, Jacobsen G, Selektor Y, Velez M, Williams C, Nemeh H, Borgi J, Morgan J, Lanfear D, and Tita C. The incidence of spontaneous intracranial hemorrhage is associated with infection in patients with mechanical circulatory support J Heart Lung Transplant 2016; 35(4):S246. PMID: Not assigned. Abstract

Rebhan N, Bebanic M, Yoshida A, Macaulay T, Goldstein E, Ho CX, Eshelman A, Abouljoud M, Jesse M, and Rizzari M. Psychiatric characteristics of acute liver failure patients: Acetaminophen overdose versus other etiologies Am J Transplant 2016; 16:524. PMID: Not assigned. Abstract

Shaikh S, Stenz J, McVinnie D, Morrison J, Getzen T, Carlin A, and Mir F. Percutaneous gastric remnant gastrostomy following roux-en-Y gastric bypass surgery: A single tertiary center's twelve year experience J Vasc Interv Radiol 2016; 27(3):S43. PMID: Not assigned. Abstract

Takahashi K, Putchakayala K, Malinzak L, Denny J, Yoshida A, Abouljoud M, and Kim D. Is ketorolac really safe for living donor nephrectomy? Am J Transplant 2016; 16:50-50. PMID: Not assigned. Abstract

Takahashi K, Putchakayala K, Malinzak L, Denny J, Abouljoud M, and Kim D. Is ketorolac really safe for donor nephrectomy? Am J Transplant 2016; 16:485. PMID: Not assigned. Abstract

Takahashi K, Putchakayala K, Rizzari M, Collins K, Nagai S, Yoshida A, Abouljoud M, and Schnickel G. Multifactorial prediction of biliary stricture after liver transplantation: The impact of platelet counts Am J Transplant 2016; 16:667-668. PMID: Not assigned. Abstract

Tinney F, Yessayan L, Abouljoud M, and Patel A. Characterization of vascular lesions in living donor renal transplant implant biopsies Am J Transplant 2016; 16:646. PMID: Not assigned. Abstract

195 Varban OA, Cassidy RB, Sheetz KH, Stricklen A, Pesta C, Genaw J, Carlin AM, and Finks JF. Evaluating the effect of technique and devices on leaks after laparoscopic sleeve gastrectomy Surg Endosc 2016; 30:S462. PMID: Not assigned. Abstract

Varban OA, Niemann A, Schram J, Carlin AM, Poplawski SC, and Dimick JB. Video analysis of surgery: Defining the data set of the future Surg Endosc 2016; 30:S482. PMID: Not assigned. Abstract

Vincenti F, Medina Pestana J, Abouljoud M, Bresnahan B, Duro Garcia V, Mulloy L, Rice K, Rostaing L, Zayas C, Calderon K, Meier-Kriesche U, Polinsky M, Zhao H, and Larsen C. Outcomes in black vs non-black patients administered belatacept (bela) or cyclosporine (CSA) in benefit Am J Transplant 2016; 16:743. PMID: Not assigned. Abstract

Wang DD, Eng M, Myers E, Forbes M, Karabon P, Greenbaum A, and O'Neill W. Inferior and posterior: Utilization of 3D print and computer aided design to spatially map optimal transseptal crossing point for left atrial appendage occlusion with the watchman device J Am Coll Cardiol 2016; 67(13):323. PMID: Not assigned. Abstract

Xuereb L, Kaur B, Akrawe S, Nemeh HW, Borgi J, Lanfear DE, Williams CT, Paone G, and Morgan JA. Does preoperative atrial fibrillation increase the incidence of thromboembolic complications in patients supported with long- term LVADs? J Heart Lung Transplant 2016; 35(4):S130-S131. PMID: Not assigned. Abstract

Xuereb L, Kaur B, Akrawe S, Rashty J, Nemeh HW, Borgi J, Lanfear DE, Williams CT, Paone G, and Morgan JA. Reoperation for bleeding does not adversely impact long-term outcomes in LVAD recipients J Heart Lung Transplant 2016; 35(4):S249. PMID: Not assigned. Abstract

Xuereb L, Kaur B, Akrawe S, Rashty J, Nemeh HW, Borgi J, Tita C, Selektor Y, Velez M, Lanfear DE, Williams CT, Paone G, and Morgan JA. Drive line infections are not associated with an increased incidence of thromboembolic complications in patients on continuous flow LVAD support J Heart Lung Transplant 2016; 35(4):S246. PMID: Not assigned. Abstract

Yadav P, Eng M, Divine G, Wang DD, Arjomand-Fard H, Wyman J, Isley M, Borgi J, Paone G, Greenbaum A, and O'Neill W. Outcomes of impella assisted percutaneous balloon aortic valvuloplasty in very high risk severe aortic stenosis patients J Am Coll Cardiol 2016; 67(13):404. PMID: Not assigned. Abstract

196 UROLOGY

Abdollah FFH, Dalela D, Sammon J, Sood A, Fossati N, Gandaglia G, Suardi N, Gaboardi F, Pini G, Jeong W, Rogers C, Peabody J, Montorsi F, Briganti A, Menon M, and Dalela D. Late recovery of erectile function in men treated with robotic-assisted laparoscopic radical prostatectomy (RALP): A novel nomogram development and validation European Urology, Supplements 2016; 15(3):e447. PMID: Not assigned. Abstract

Abdollah FFH, Dalela D, Sood A, Meyer C, Sun M, Trinh QD, Menon M, Sammon J, and Dalela D. The impact of 2012 United States Preventive Services Task Force (USPSTF) panel update on PSA screening practice: A nationwide, and state-by-state level analyses European Urology, Supplements 2016; 15(3):e91+e91a. PMID: Not assigned. Abstract

Abdollah FFH, Dalela D, Sood A, Sammon J, Karabon P, Meyer C, Sun M, Choueiri T, Menon M, Trinh QD, and Dalela D. Temporal trends in prostate cancer (PCa) risk group stratification following the 2008 United States preventive services task force recommendations European Urology, Supplements 2016; 15(3):e726. PMID: Not assigned. Abstract

Bazzi M, Abdullah N, Karabon P, Chick J, and Dabaja AA. Trends in embryo transfer rate, multiple birth rate, and pregnancy rate in response to the american society of reproductive medicine's recommendation to limit embryotransfer Fertility and Sterility 2016; 106:e325. PMID: Not assigned. Abstract

Dalela D, Barod R, Gandaglia G, Abaza R, Adshead J, Ahlawat R, Buffi N, Challacombe B, Dasgupta P, Moon D, Parekh D, Porpiglia F, Rawal S, Novara G, Bhandari M, Rogers C, and Mottrie A. Outcomes of robot-assisted partial nephrectomy in patients with complex renal tumours and pre- existing chronic kidney disease in a multi-institutional, multinational database Eur Urol, Supplements 2016; 15(3):e412. PMID: Not assigned. Abstract

Den RB, Yousefi K, Trock B, Davicioni E, Tosoian J, Thompson D, Choeurng V, Haddad Z, Tran PT, Trabulsi E, Gomella LG, Lallas CD, Abdollah F, Feng FY, Dicker AP, Freedland SJ, Karnes JR, Schaeffer EM, and Ross AE. Efficacy of postoperative radiation in a prostatectomy cohort adjusted for clinical and genomic risk Int J Radiat Oncol Biol Phys 2016; 96(2s):S103-s104. PMID: 27675531. Full Text Abstract

Diaz M, Chang S, and Singer M. Adherence to dietary indexes by diabetes and hypertension status among PLCO cancer screening trial participants Adv Nutr 2016; 7(1):38A. PMID: Not assigned. Abstract

Eleswarapu S, Sood A, Abdollah F, Sammon J, Jeong W, Dalela D, Klett D, Peabody J, Eswara J, Menon M, Trinh QD, and Dabaja A. Complications following male re-constructive urologic surgery Eur Urol, Supplements 2016; 15(3):e326. PMID: Not assigned. Abstract

Elgin R, Pacha T, Di Loreto R, and George V. Office based photovaporization of the prostate for benign prostatic hyperplasia: Outcomes and patient satisfaction Urology Practice 2016; 3(1):70- 75. PMID: Not assigned. Abstract

Feng FY, Karnes JR, Ashab HA, Trock B, Ross AE, Tsai H, Tosoian J, Erho NG, Alshalafa M, Choeurng V, Yousefi K, Abdollah F, Klein EA, Nguyen PL, Dicker AP, Den RB, Davicioni E, Jenkins RB, Lotan T, and Schaeffer EM. Development and validation of genomic signature that predicts androgen deprivation therapy treatment failure Int J Radiat Oncol Biol Phys 2016; 96(2s):E221. PMID: 27674101. Full Text Abstract

Freytag SO, Movsas B, and Stricker H. Clinical trials of oncolytic adenovirus-mediated gene therapy Mol Ther 2016; 24:S205-S205. PMID: Not assigned. Abstract

Gadde R, Barod R, Rogers CG, Gupta NS, and Williamson SR. The spectrum of oncocytic renal tumors from oncocytoma to eosinophilic variant chromophobe renal cell carcinoma - is there a need to sub-classify and what is the malignant potential? Lab Invest 2016; 96:231A-231A. PMID:

197 Not assigned. Abstract

Gadde R, Gulati R, Inamdar KV, Michalowski S, and Menon M. Cytogenetic analysis is crucial in the early diagnosis of indolent t-cell prolymphocytic leukemia Lab Invest 2016; 96:345A-345A. PMID: Not assigned. Abstract

Gandaglia G, Zazzara M, Abaza R, Adshead J, Ahlawat R, Buffi NM, Challacombe B, Dasgupta P, Moon DA, Parekh DJ, Porpiglia F, Rawal S, Novara G, Rogers C, Bhandari M, and Mottrie A. Preoperative predictors of renal failure after robot-assisted partial nephrectomy: Analysis of the Vattikuti Global Quality Initiative in Robotic Urologic Surgery (GQI-RUS) database Eur Urol, Supplements 2016; 15(3):e409. PMID: Not assigned. Abstract

Ghani KR, Aly A, Peabody J, Lane B, Sarle R, Abaza R, Montgomery J, Hu J, Eun D, Fumo M, Comstock B, Linsell S, Miller DC, and Guru K. Assessment of surgical competency for robot-assisted radical prostatectomy: Development and validation of prostatectomy assessment and competency evaluation (PACE) Eur Urol, Supplements 2016; 15(3):e364. PMID: Not assigned. Abstract

Griffin M, Diaz-Insua M, ElShatanoufy S, and Atiemo H. Medical student robotic simulator performance does not correlate with their usmle scores Neurourol Urodyn 2016; 35:S14-S15. PMID: Not assigned. Abstract

Hanna N, Zavaski M, Gelpi-Hammerchmidt F, Meyer C, Sammon J, Kibel A, Menon M, Leow J, Sun M, Abdollah F, and Trinh QD. Informed decision-making for prostate-specific antigen screening Eur Urol, Supplements 2016; 15(3):e94. PMID: Not assigned. Abstract

Jamal M, Williamson SR, Diaz-Insua M, Menon M, Stricker H, Peabody J, Rogers CG, and Gupta NS. Significance of percentage of gleason pattern 4 at needle biopsy in predicting final gleason score and correlation with pathologic outcomes at radical prostatectomy Lab Invest 2016; 96:240A-240A. PMID: Not assigned. Abstract

Jamal M, Williamson SR, Diaz-Insua M, Menon M, Stricker H, Peabody J, Rogers CG, and Gupta NS. Clinical significance of percentage of gleason pattern 4 in gleason score 7 prostate cancer at radical prostatectomy Lab Invest 2016; 96:240A-240A. PMID: Not assigned. Abstract

Karnes J, Ashab HA, Trock BJ, Ross A, Tsai H, Tosoian JJ, Erho N, Choeurng V, Yousefi K, Haddad Z, Abdollah F, Klein EA, Nguyen PL, Feng FYC, Dicker A, Den RB, Davicioni E, Jenkins RB, Lotan TL, and Schaeffer EM. Development and validation of an ADT resistance signature to predict adjuvant hormone treatment failure J Clin Oncol 2016; 34(2):1. PMID: Not assigned. Abstract

Li HH, Borchert A, and Atiemo H. Contemporary treatment of detrusor sphincter dyssynergia: A systematic review Neurourol Urodyn 2016; 35:S54-S55. PMID: Not assigned. Abstract

Löppenberg B, Meyer C, Hanna N, Cole A, Vetterlein M, Menon M, Sammon J, Leow J, Kibel A, and Trinh QD. Sling procedures for female stress incontinence: Does surgical specialty matter? Eur Urol, Supplements 2016; 15(3):e7. PMID: Not assigned. Abstract

Lovegrove CE, Novara G, Guru K, Mottrie A, Challacombe B, Raza J, Van Der Poel H, Peabody J, Popert R, Dasgupta P, and Ahmed K. Learning curve in robot-assisted radical prostatectomy: Practice makes perfect, but what practice? Eur Urol, Supplements 2016; 15(3):e363. PMID: Not assigned. Abstract

Lu ZC, Williamson SR, Diaz-Insua M, Stricker H, Menon M, and Gupta NS. Pathologic outcomes and biochemical recurrence (BCR) free survival in men younger than 45 years with prostate cancer (PCa) treated with robotic radical prostatectomy (RRP) Lab Invest 2016; 96:247A- 247A. PMID: Not assigned. Abstract

Meyer C, Feldman A, Sanchez A, Reznor G, Hanske J, Hanna N, Kibel A, Sammon J, Cole A, Leow J, Sun M, and Trinh QD. Morbidity, mortality and costs of treatment for locally advanced prostate cancer: A populationbased analysis comparing radical prostatectomy and external beam radiation

198 Eur Urol, Supplements 2016; 15(3):e71. PMID: Not assigned. Abstract

Meyer C, Friedlander D, Choi K, Cole A, Abdollah F, Hanske J, Zavaski M, Sammon J, Leow J, Menon M, Sun M, Kibel A, and Trinh QD. A nationwide survey of prostate specific antigen based screening and counseling for prostate cancer Eur Urol, Supplements 2016; 15(3):e93. PMID: Not assigned. Abstract

Meyer C, Sood A, Abdollah F, Sammon J, Vetterlein M, Löppenberg B, Hanske J, Leow J, Cole A, Sun M, Menon M, and Trinh QD. Minimally invasive vs open radical prostatectomy: An analysis of 30- day postoperative complications, unplanned readmissions, and mortality Eur Urol, Supplements 2016; 15(3):e443. PMID: Not assigned. Abstract

Meyer C, Trinh QD, Vetterlein M, Löppenberg B, Hanske J, Leow J, Sammon J, Abdollah F, Menon M, Kibel A, Chang S, Choueiri T, and Sun M. Trends of metastasectomy for metastatic renal cell carcinoma and their impact on overall survival Eur Urol, Supplements 2016; 15(3):e755. PMID: Not assigned. Abstract

Meyer C, Zavaski M, Hanske J, Friedlander D, Cheng P, Menon M, Kibel A, Cole A, Leow J, Abdollah F, Sun M, Sammon J, and Trinh QD. Differences in prostate specific antigen testing among urologists and primary care providers in the United States following the 2011 USPSTF recommendations Eur Urol, Supplements 2016; 15(3):e90. PMID: Not assigned. Abstract

Ross A, Den R, Yousefi K, Trock B, Davicioni E, Tosoian J, Thompson D, Choeurng V, Haddad Z, Tran P, Trabulsi E, Gomella L, Lallas C, Abdollah F, Feng F, Dicker A, Freedland S, Karnes J, and Schaeffer E. Efficacy of early and delayed radiation in a prostatectomy cohort adjusted for genomic and clinical risk Eur Urol, Supplements 2016; 15(3):e435. PMID: Abstract

Sood A, Ghosh P, Jeong W, Bhandari M, Ahlawat R, and Menon M. Robotic kidney transplantation with regional hypothermia: Results from a prospective two-arm non-randomized controlled trial (Ideal phase 2b) Eur Urol, Supplements 2016; 15(3):e715. PMID: Not assigned. Abstract

Sood A, Sammon J, Abdollah F, Klett D, Dalela D, Kibel A, Pucheril D, Schmid M, Jeong W, Dabaja A, Rogers C, Peabody J, Menon M, Trinh Q, and Abdollah F. Complications after adrenalectomy-does the speciality matter? Eur Urol, Supplements 2016; 15(3):e485. PMID: Not assigned. Abstract

Vetterlein M, Meyer C, Löppenberg B, Sammon J, Hanske J, Menon M, Preston M, Chun F, Kibel A, Fisch M, and Trinh QD. Radical cystectomy for bladder cancer vs non-malignant indications: Preoperative predictors of perioperative outcomes in a sample of 3269 patients Eur Urol, Supplements 2016; 15(3):e632. PMID: Not assigned. Abstract

Williamson SR, Chitale DA, Favazza L, Barod R, Rogers CG, Palanisamy N, and Gupta NS. Clear cell renal cell tumors with intact VHL and chromosome 3p: how many entities exist? Lab Invest 2016; 96:271A-271A. PMID: Not assigned. Abstract

Williamson SR, Grignon DJ, Favazza L, Gupta NS, Chitale DA, and Palanisamy N. Chromosome 6p amplification including the TFEB gene: a novel mechanism of renal cell carcinoma pathogenesis? Lab Invest 2016; 96:270A-271A. PMID: Not assigned. Abstract

199