TUESDAY, APRIL 23 Anatomy
956. ANATOMY EDUCATION A242 956.14 Types of tracheal submucosal glands: implications of literature controversy. M.D. Barros, A.P. Landim, Poster A.C.M. Dobre, J.D.B. Andreotti, D.F. Curcio and A.L. Duarte. Santa Casa Sch. of Med. Sci. and São Camilo Univ. Ctr., São Tue. 7:30 am—Boston Convention & Exhibition Center, Paulo. Exhibit Halls A-B A243 956.15 Assessing the value of clay modeling as an Presentation time: 12:30 pm-2:00 pm effective adjunct to human donor dissection. J.A. Rosentsveyg, J. Patel, T. Adar and S. Marquez. SUNY Downstate Med. Ctr. A229 956.1 Head to head: the role of competition in A244 956.16 The new anatomist: preparing to teach in an undergraduate education. S.E. Van Nuland, V.A. Roach, T.D. integrated medical curriculum. G.M. Sorrentino. Hofstra North Wilson and D.J. Belliveau. Sch. of Hlth. Sci., Univ. of Western Shore-Long Island Jewish Sch. of Med. Ontario. A245 956.17 Human structure in 7 weeks: one approach A230 956.2 Comparison between student desired grades to providing foundational anatomical competency in an era and actual final grades in undergraduate human anatomy. S. of compressed medical school curricula. N.L. Halliday, D. Dunham. Indiana Univ. O’Donghue and B. Thompson. Univ. of Oklahoma Col. of A231 956.3 Student peer review and self-reflection in Med. the gross anatomy laboratory: identifying student perceived A246 956.18 The integration of osteology, radiology, and strengths and areas for improvement. A. Edmondson, J.E. surface anatomy into a clinical skills 101 course for first-year Mackey, R. Shelley and C. Nichols. Med. Col. of Georgia, medical students. B.F. Giffin, D.J. Lowrie, D. Pettigrew and A. Georgia Hlth. Sci. Univ. Gunderson. Univ. of Cincinnati Col. of Med. A232 956.4 A comparison of medical student and A247 956.19 Integrating geriatrics with anatomy: an undergrad study skills in anatomy lab courses. J.B. Barger educational collaboration between basic science and primary and P. Husmann. Indiana Univ. and Ashland Univ., OH. care. K.T. Kleber, M. Young and A. Zumwalt. Boston Univ. A233 956.5 The effect of training on individuals’ interactions Sch. of Med. and Boston Med. Ctr. with visual data. L.A. Pfaff, K. Colliard and A. Zumwalt. A248 956.20 Teaching oncology residents anatomy: a Boston Univ. multidisciplinary (MDT) approach. L. D’Souza, J. Jaswal, M. A234 956.6 Training increases subjects’ fixation time Johnson, F. Chan, K.Y. Tay, K. Fung and D. Palma. Western on cognitively salient locations. K. Colliard, L. Pfaff and A. Univ., London Hlth. Sci. Ctr. - Victoria Hosp. and London Reg. Zumwalt. Boston Univ. Cancer Prog., Canada. A235 956.7 Relationship between spatial abilities and A249 956.21 Physician assistant anatomy education: does three-dimensional synthesis of structures. J. Langlois, Y. prior anatomy experience predict performance? C.E. Terhune, Dagenais, R. Lemieux, M. Martin, M. Lecourtois, E. Yetisir, B.Q. Melcher and A.B. Taylor. Duke Univ. Sch. of Med. G. Bergeron, S. Hamstra and G.A. Wells. Hosp. Ctr., Univ. of A250 956.22 Addressing common and specific educational Sherbrooke and Univ. of Ottawa, Canada. goals of the medical illustration discipline-based anatomical A236 956.8 Relationship between spatial abilities and courses that partially overlap with system-based modules in cross-sectional drawings. J. Langlois, Y. Dagenais, C. the medical school curriculum. C. Stefan, W.M. Andrews and Bellemare, R. Lemieux, M. Martin, M. Lecourtois, E. Yetisir, S.J. Harrison. Med. Col. of Georgia and Col. of Allied Hlth. Sci. G. Bergeron, S. Hamstra and G.A. Wells. Sherbrooke Univ. at Georgia Regents Univ. Hosp. Ctr., Univ. of Sherbrooke, Canada and Univ. of Ottawa. A251 956.23 A roadmap for survey design in anatomy T A237 956.9 Top-down influences on visuospatial human education research. K.A. Metzger and R. MacKay. Hofstra U anatomy comprehension. K. Glena, M. Johnson and N. North Shore-Long Island Univ. Sch. of Med. and Hofstra Univ. E Nguyen. Univ. of Western Ontario. A252 956.24 An overview of study methodology and A238 956.10 Exploring the learning environment in a knowledge retention in veterinary anatomy on DVM students. medical school anatomy course: does group emotional C. Trincado, J.C. Gutierrez and L. Freeman. Virginia Tech intelligence affect team performance? S.G. Porter, M. Holman, Col. of Vet. Med. N. Lachman and W. Pawlina. Mayo Med. Sch. and Mayo Clin. A253 956.25 Dissection of the supra-clavicular region, a A239 956.11 Performance in medical gross anatomy as a plaster of the B. cuneo’s collection. P. Le Floch-Prigent. Med. predictor of USMLE Step 1 scores. D. Fletcher and D. Musick. Sch., UFR Med. PIFO, Versailles-Saint Quentin Univ., France. Brody Sch. of Med. at East Carolina Univ. A254 956.26 An enlarged anatomical model of the eye in A240 956.12 Methods for the teaching of gross anatomy: a papier mâché by the Doctor Auzoux. P. Le Floch-Prigent. qualitative look at the use of cadaver dissection, prosection, PIFO Med. Sch., Versailles-Saint Quentin Univ., France. plastination, and computer-aided technology as effective A255 956.27 Anatomy at West Virginia University: 1867- methods. L.J. Day, M. Goldberg, E. Molloy, K.C. Moran and 2012. J.L. Culberson. West Virginia Univ. C. Rocco. Northeastern Univ. A241 956.13 Integrative online/onsite system enhances histology learning in medical education. D.F. Curcio, E.S. Yonamine and M.D. Barros. Santa Casa Sch. of Med. Sci., São Paulo.
321 ANATOMY TUESDAY
957. ANATOMY EDUCATION: ASSESSMENT, A270 957.15 Correlation of student performance on team CURRICULUM AND MENTORING based learning with exams in systems based first year medical school courses. G.D. Guttmann and A. Rosales. Univ. of Poster North Texas Hlth. Sci. Ctr. A271 957.16 Student perceptions and preferences of two Tue. 7:30 am—Boston Convention & Exhibition Center, TBL modalities in the second year medical curriculum. J.S. Exhibit Halls A-B Waggoner, M.W. Braun and V. Dean O’Loughlin. Indiana Presentation time: 12:30 pm-2:00 pm Univ. A272 957.17 Focused preparation of anatomy and A256 957.1 Reflective writing highlights improved student physiology instructors for the undergraduate college and metacognition in an upper level undergraduate anatomy university setting—a report on the first cohort. R. Crocker. New course. V.D. O’Loughlin and L.M. Griffith. Indiana Univ. and York Chiropractic Col. Central Michigan Univ. A273 957.18 Anatomy education in an integrated curriculum: A257 957.2 Assessing the cultural beliefs of medical importance and benefits of training and evaluation of clinical students: impact on the cadaveric dissection experience in the faculty. W. Rennie, K. Metzger and D. Elkowitz. Hofstra North gross anatomy laboratory. R. Khalil, J. Krum, A.R. Jurjus, F. Shore-Long Island Jewish Sch. of Med. Slaby and R.A. Jurjus. George Washington Univ. Sch. of Med. A274 957.19 The intermingled history of occupational and Hlth. Sci. and American Univ. of Beirut. therapy and anatomical education – a retrospective exploration. A258 957.3 What do medical students learn from the M.A. Carroll and K.A. Lawson. Univ. of Texas at El Paso. process of dissection? H.D. Nicholson, A. Barrett and H. A275 957.20 Developing competency in communication: Martyn. Univ. of Otago, New Zealand. medical student perceptions of patients’ knowledge of anatomy. A259 957.4 Varying effects of prosection and dissection D. Dudenkov, J. Primus, S. Mayer, W. Pawlina and N. anatomy curriculums on confidence in the clinical setting. S. Lachman. Mayo Med. Sch. and Mayo Clin. Young, C.R. Guzman, P.F. Wimmers, C.V. Byus and J.J. A276 957.21 Effects of classroom structure on retention Wisco. David Geffen Sch. of Med. at UCLA, UCR/UCLA, and implementation of knowledge in students. A.M. Banda, K. Riverside and Brigham Young Univ. Steed, N. Schmalz, K. Ojukwu, M. Diaz, J. Padilla and J.J. A260 957.5 Anatomical knowledge retention in third year Wisco. UCLA and Brigham Young Univ. medical students prior to OB/GYN and surgery rotations. R.A. Jurjus, J. Krapf, S. Ahle, K. Brown, G. Butera, E. Goldman 958. ANATOMY EDUCATION: CLINICAL-BASED and J. Lee. George Washington Univ. APPROACHES A261 957.6 Medical student feedback on participating in a combined anatomy curriculum, 2010-2012. C. Guzman, S. Poster Young, P. Wimmers, C. Byus and J. Wisco. David Geffen Sch. of Med. at UCLA, UCR/UCLA Thomas Haider Prog. in Biomed. Tue. 7:30 am—Boston Convention & Exhibition Center, Sci., Riverside and Brigham Young Univ. Exhibit Halls A-B A262 957.7 Designing effective student presentation assignments that include thoughtful peer assessment. S.A. Presentation time: 12:30 pm-2:00 pm Miller. Hamilton Col., NY. A277 958.1 Cadaver presentations: an integrative, A263 957.8 Opportunities in a new medical school: a clinical approach to anatomy. J.W. Denham, F. Robichaud, longitudinal, integrated clinical anatomy curriculum. M. Hankin, C.L. Abercrombie, T.E. Kwasigroch, B.M. Browe and P.J. M. Bee, W. Forbes, J. Montante, J. Eastwood, I. Hajj-Hussein, Monaco. Quillen Col. of Med., Mountain Home, TN. N. Afonso, A. Poznanski, J. Venuti and D. Gould. Oakland Univ. A278 958.2 An interprofessional approach to improve William Beaumont Sch. of Med. gestational outcomes. L.J. von Hagen, D. Penava, M. Johnson A264 957.9 Codebook analysis of metacognitive blogs in and M. Mottola. Univ. of Western Ontario and Schulich Sch. of an anatomy learning skills course. A. Schutte. Indiana Univ. Med. and Dent., London, Canada. A265 957.10 Effect of time limits during anatomy practical A279 958.3 The pyramidal lobe: connecting a case study exams on student performance. G. Zhang, B.A. Fenderson, with lymphatic system topics in gross anatomical education. K. R.R. Schmidt and J.J. Veloski. Thomas Jefferson Univ. Cassidy. Indiana Univ. A266 957.11 Does exam performance correlate with A280 958.4 Specialized anatomy electives for fourth year perception of readiness or pretest quizzes? A. Ball, L. Belbeck, medical students in preparation for residency specialties: N. Volc, P. Helli and B. Wainman. McMaster Univ., Canada. plastic surgery, orthopaedics, and obstetrics & gynecology. A267 957.12 Evaluating an anatomy-specific tool for N.S. Viscomi, S. Suprenant-Kotal, B.K. Jones, R.A. Combs Blooming exam questions. A.R. Thompson and V.D. and R.W. Clough. SIU Sch. of Med. Carbondale. O’Loughlin. Indiana Univ. A281 958.5 An interprofessional learning module on bone A268 957.13 E-testing in anatomical teaching. J. Streicher. marrow biopsy within the preclinical undergraduate medical Med. Univ. of Vienna. curriculum. A. Poznanski, R. McGranahan, J. Eastwood and A269 957.14 Statistical analysis of anatomy final examination J. Venuti. Oakland Univ. William Beaumont Sch. of Med. and grades of Hungarian, German and English speaking medical Univ. of Michigan. students at the Semmelweis University. A.D. Székely, S.M. A282 958.6 An introduction to ultrasonography: a novel Attardi and K.A. Rogers. Semmelweis Univ., Hungary and teaching session for final year medical students. R. Subbu, N. Western Univ., Canada. Mackay and P. Abrahams. Warwick Univ., U.K. A283 958.7 Stereo laparoscopy: a novel approach to resident surgical education. V. Roach, M. Mistry and T. Wilson. Univ. of Western Ontario.
322 TUESDAY ANATOMY
A284 958.8 Medical students perceptions of ultrasound A300 959.13 Digital atlas for ultrasound-guided regional use for gross anatomy teaching by clinicians and anatomists. never blocks of the trunk. A. Stone, M. Johnson and S. R.A. Jurjus, K. Dimorier, K. Brown, F. Slaby, K. Calabrese Ganapathy. Univ. of Western Ontario Schulich Sch. of Med. and Y.T. Liu. George Washington Univ. and Dent. A285 958.9 Ultrasound imaging the liver: a supplement to A301 959.14 Spatial ability and cognitive load demands abdominal dissection. V.H. Lee. Texas Tech Univ. Hlth. Sci. Ctr. during visual learning and testing: a transcranial Doppler A286 958.10 Application of stereoscopic visualization on ultrasound study. J. Loftus and T.D. Wilson. Univ. of Calgary/ surgical skill acquisition in novices. M. Mistry, V.A. Roach and Schulich of Med. & Dent., Univ. of Western Ontario. T.D. Wilson. Univ. of Western Ontario. A287 958.11 Integration of histology and pathology in a 960. ANATOMY EDUCATION: TEACHING METHODS senior elective course curriculum. D. Cui and W. Daley. Univ. of AND INNOVATIONS Mississippi Med. Ctr. Poster 959. ANATOMY EDUCATION: COMPUTER-ASSISTED LEARNING Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B
Poster Presentation time: 12:30 pm-2:00 pm
Tue. 7:30 am—Boston Convention & Exhibition Center, A302 960.1 Evaluation of anatomy comic strips for further Exhibit Halls A-B production and applications. M.S. Chung. Ajou Univ. Sch. of Med., South Korea. Presentation time: 12:30 pm-2:00 pm A303 960.2 Cadaver lab, white boards and pedagogy: A288 959.1 3D reconstructions of early heart development uniting teachers, students and anatomy. N. Harper, D.A. as an educational resource. V.M. Piet and R.J. Cork. LSU Hlth. Morton and M.T. Nielsen. Univ. of Utah Sch. of Med. and Univ. Sci. Ctr., New Orleans. of Utah. A289 959.2 Taking A SecondLook™ at teaching histology – A304 960.3 Collaborative key features problems in development of a self-evaluation iPad application. M. Hortsch. anatomy: assessment drives clinical decision making and Univ. of Michigan. anatomical learning. M. Terrell, J. Kalmey and R. Kulesza. A290 959.3 Online histology modules for first-year medical Lake Erie Col. of Osteo. Med. students: a student to student approach. M.V.C. Butler, H.N. A305 960.4 Medical student perceptions of a radiology Yule and K.E. Pinder. Sch. of Popul. and Publ. Hlth., Univ. of tutorial in anatomy education. A. Hoover, L. Smith, P. Brian British Columbia. and M. Lazarus. Penn State Col. of Med. A291 959.4 Use of an audience response (ARS) in an A306 960.5 Movement Guided Learning© as a novel interactive histology laboratory. P.C. Feasel, E. Xanthos, N. means of musculoskeletal anatomy instruction. D.C. Bentley. Borges and L. Ream. Wright State Univ. Univ. of Toronto. A292 959.5 Guided, self-directed learning: building an A307 960.6 A learning strategy for the muscles and fascial anatomy learning module for the iPad. M.L. Haugsdal and planes of the head and neck. L.E. Sanders, D.A. Morton and M.A. Pizzimenti. Univ. of Iowa Carver Col. of Med. M.T. Nielsen. Univ. of Utah. A293 959.6 Learning human neuroanatomical structure A308 960.7 Understanding human cranial nerves through and function using a computer-based learning tool. A.R. a patterned based comparative approach. J.A. Bohn, D.A. Severson and D.J. Forbes. Univ. of Minnesota Duluth. Morton and M.T. Nielsen. Univ. of Utah. A294 959.7 Combining e-learning with practical A309 960.8 3D Atlas of Human Embryology: creating an anatomy—a new dissection manual. L. Hirtler, M. Zauleck application as a new learning tool. B.S. de Bakker and A.F.M. and J. Streicher. Med. Univ. of Vienna and Katharinenhosp., Moorman. Acad. Med. Ctr., Amsterdam. T Stuttgart. A310 960.9 Innovative technology expands student A295 959.8 Anatomical animation: new frontiers in gross laboratory experience during medical gross anatomy course: U anatomy instruction. D.C. Peterson and C. Robertson. Iowa addition of iPads in lab revolutionizes how anatomy is taught. E State Univ. C.L. Abercrombie, N. Yogesh, L.Q. Olive, J.A. Miller, J.W. A296 959.9 Interactive video animations as a study guide Denham, B.M. Browe and T.E. Kwasigroch. Quillen Col. of for the human skeleton: 1. The scapula. G.P. Casey, P.D. Oliver Med., East Tennessee State Univ. and R.J. Cork. LSU Hlth. Sci. Ctr., New Orleans. A311 960.10 Interactive educational touch screen panels in A297 959.10 The role of clinical imaging tutorials in anatomy anatomy laboratuary training. F. Yazar, S. Develi and B. Yalcin. education. L. Smith, A. Hoover, P. Brian and M. Lazarus. Gulhane Military Med. Acad., Turkey. Penn State Col. of Med. A312 960.11 Your voice sounds fine: making podcasts to A298 959.11 Development of a virtual 3D renal corpuscle for promote learning. E.W. Dewar. Suffolk Univ., MA. educational environments. J. Roth, T. Wilson and M. Sandig. A313 960.12 Teaching secular trends of human anatomy in Univ. of Western Ontario. a novel medical school module. F. Rühli, A. Saniotis and M. A299 959.12 Establishing the validity and reliability of Henneberg. Univ. of Zurich and Univ. of Adelaide. computer-based simulation for cerebral angiography using A314 960.13 Retrieval learning as a guiding tool for the ANGIO Mentor Express. N. Nguyen, R. Eagleson and prematriculation students in the study of histology. D. Cui, A.K. S. deRibaupierre. Western Univ. and London Hlth. Sci. Ctr., Pavlov, T. Yang and J.C. Lynch. Univ. of Mississippi Med. Ctr. Canada. A315 960.14 Peer teaching in an online histology classroom. M. Barbeau and K.A. Rogers. Western Univ., Canada.
323 ANATOMY TUESDAY
A316 960.15 Dual-lecturer-mode in teaching advanced A333 960.32 Day one: what are the possibilities for the first medical histology. J. Chen, W. Daley and D. Cui. Univ. of day of gross anatomy courses? K.A. Metzger, D.E. Elkowitz Mississippi Med. Ctr. and W. Rennie. Hofstra North Shore-Long Island Jewish Sch. A317 960.16 Anatomy academy promotes systems-based of Med. practice among medical and undergraduate students. K. A334 960.33 Mobilizing clinical imaging, 3D anatomy, and Ojukwu, J. Padilla, M. Diaz and J. Wisco. Charles R. Drew digital microscopy data for virtual reality learning objects: Univ., UCLA David Geffen Sch. of Med., Luskin Sch. of Publ. HTML5 and ubiquitous learning methods. R.B. Trelease. David Affairs and Fielding Sch. of Publ. Hlth. and Brigham Young Univ. Geffen Sch. of Med. at UCLA. A318 960.17 Multimodal virtual anatomy learning tools A335 960.34 New applications in anatomical education for medical education using recent advances in IT. G. using soft-embalmed cadavers. N.T. Boaz, R. Sikon, D. Sikon, Pnnamaplam. YLL Sch. of Med., Natl. Univ. of Singapore. L.N. Forest and J.R. Wells. Integrat. Ctrs. for Sci. and Med., A319 960.18 Evaluation of a novel online systemic human Martinsville, VA, Virginia Commonwealth Univ., Virginia Dept. anatomy course. S.M. Attardi and K.A. Rogers. Western of Hlth. and Univ. of South Carolina Sch. of Med. Univ., Canada. A336 960.35 The relationship between in-class written A320 960.19 Student perceptions and effectiveness of exercise and exam performance in an allied health gross team-based learning in anatomy. P.B. Palmer. North Georgia anatomy course. K.M. Warren. Brody Sch. of Med. at East Col. & State Univ. Carolina Univ. A321 960.20 Team-based learning in histology: lessons A337 960.36 Texas Tech System for student peer teaching learned through 7 years of experience. J.J. Brokaw and K.W. in anatomy: didactic small group sessions. B.L. Schneider and Condon. Indiana Univ. Sch. of Med. V.H. Lee. Texas Tech Hlth. Sci. Ctr. A322 960.21 Selected versus constructed response in A338 960.37 The development and assessment of a medical assessing anatomy knowledge?outcomes from a brief study. education resource that uses surface anatomy to create a link C. Vasan and N. Vasan. New Jersey Med. Sch., Newark. between gross anatomy and clinical skills. J. Szymus. Queen’s A323 960.22 Heart development tutorial – heart tube folding. Univ., Canada. T.M. DeLorenzo and A. Zumwalt. Boston Univ. A339 960.38 Horizontal and vertical integration of basic A324 960.23 Evaluation of gross anatomy teaching styles at sciences within the undergraduate medical curriculum: the University of Auckland. K. Reilly, A. Wearn and P. Riordan. development of high yield modules for contextual learning. A. Univ. of Auckland, New Zealand. Poznanski, I. Niculescu, D. Gould and M. Hankin. Oakland A325 960.24 Use of a Wiki as a collaborative learning tool to Univ. William Beaumont Sch. of Med. and Beaumont Hosp., promote active learning in a neuroscience course for first-year Royal Oak, MI. medical students. D. Gould and M. Mi. Oakland Univ. William A340 960.39 Teaching medicine through media: an Beaumont Sch. of Med. interprofessional and interdisciplinary activity with neuroscience A326 960.25 The integration of anatomy and radiology and film. A. Poznanski, N. Afonso, K. Edwards, H. Vaughan, through interactive online modules. C. Krebs, M. Fejtek, J. Hu, N. Bulgarelli, E. Krug and D. Gould. Oakland Univ. William M. Kazem, A. Lam, T. Liang, T. Zhang, S. Hayward and S. Beaumont Sch. of Med. and Oakland Univ. Nicolaou. Univ. of British Columbia. A341 960.40 Teaching surface anatomy through near-peer A327 960.26 The development of a web-based interactive instruction. S.J. Carp, K. Metzger and W. Rennie. Hofstra tool to complement anatomy and radiology teaching and North Shore-Long Island Jewish Sch. of Med. learning. C. Krebs, O. Oyedele, M. Fejtek and S. Tolhurst. A342 960.41 Video lab guides: efficacy and student Univ. of British Columbia. perception. H.J. Billings. West Virginia Univ. Sch. of Med. A328 960.27 Development of a resource for training anatomy A343 960.42 Advancing the playing field: a look at how virtual lab dissection techniques. J.H. Bladon and A. Zumwalt. reality can change the future of anatomy teaching learning Boston Univ. process. J. Duarte, C.V. Vilá, J. Vilaró and W.R. Veras. Univ. A329 960.28 Teaching anatomy online using retrieval Central del Caribe, PR. practice, 3D stereoscopic images and virtual human fly-through A344 960.43 Active learning cycle of anatomy laboratory for videos. M.A. Kolitsky. Univ. of Texas at El Paso. the Net Generation. E. De Leon and W.R. Veras. Univ. Central A330 960.29 A subscapular approach to the dissection of del Caribe, PR. the human brachial plexus. S. Hager, T. Backus, B. Futterman, A344A 960.44 Assessing the quality of dissection: a method N. Solounias and M.C. Mihlbachler. New York Inst. of Technol. for improving anatomy knowledge of first year medical students. Col. of Osteo. Med. C. Nwachukwu, N. Lachman and W. Pawlina. Mayo Med. A331 960.30 The value of drawing in anatomical education Sch. (318.6) and its effects on academic performance and retention. S.M. A344B 960.45 Safe Harbor Forum: professionalism reflection Rosa. Queen’s Univ., Canada. sessions for first year medical students in the gross anatomy A332 960.31 Dissection, prosection or both in teaching course. C. Spampinato, C. Wittich and W. Pawlina. Mayo Clin. medical gross anatomy: an old question revisited. C. Vasan, G. Med. Sch. (447.6) Pinhal-Enfield, D. DeFouw and N. Vasan. New Jersey Med. Sch., Newark.
324 TUESDAY ANATOMY
961. ANATOMY EDUCATION — EDUCATIONAL A354 962.2 Zinc supplementation prevents diabetes- COMMUNITY OUTREACH induced heart malformation in mouse model. D.K. Srinivasan, V. Murugaiyan and S.S.W. Tay. Lee Kong Chian Sch. of Med., Poster Nanyang Technol. Univ., Singapore, Natl. Univ. of Singapore and SUNY, Brooklyn. Tue. 7:30 am—Boston Convention & Exhibition Center, A355 962.3 Identification of nicotinic acetylcholine receptor Exhibit Halls A-B subunit expression in early avian embryos. Z. Haroon, J. Presentation time: 12:30 pm-2:00 pm Stathos, D. Higgins, J.T. Olley, P.R. Brauer and M.V. Reedy. Creighton Univ. A345 961.1 Our success in translating anatomy academy, A356 962.4 Developmental horizons in the 2-4 month old an intervention program for 5th and 6th grade students, from infant aerodigestive tract. B.M. Micham and J.T. Laitman. Los Angeles, CA to Salt Lake City, UT. K.S. Steed, M. Diaz, K. Mount Sinai Sch. of Med. Ojukwu, J. Padilla, K. Jenkins, J. Lassetter and J.J. Wisco. A357 962.5 Mutations disrupting PI3K signaling act as Col. of Nursing, Brigham Young Univ., UCLA David Geffen Sch. dominant enhancers of ethanol teratogenicity. N. McCarthy, of Med. and Fielding Sch. of Publ. Hlth. and Charles R. Drew L. Wetherill, C.B. Lovely, M.E. Swartz, T.M. Foroud and J.K. Univ. Eberhart. Univ. of Texas at Austin and Indiana Univ. Sch. of A346 961.2 Augmenting the learning of anatomy beyond Med. the traditional laboratory experience through service teaching A358 962.6 Historical development of the surgical of elementary school students: a medical student perspective. technique for cleft lip and palate surgery: Bourgery’s Treatise H. Lee, K. Ojukwu, M. Diaz, J. Padilla, C. Thang and J.J. on Human Anatomy, 1854. M.D. Barros, J.D.B. Andreotti, S.F. Wisco. David Geffen Sch. of Med. at UCLA, UCLA Fielding Levy, D.F. Curcio and B.M. Liquidato. Santa Casa Sch. of Sch. of Publ. Hlth. and Brigham Young Univ. Med. Sci., São Paulo. A347 961.3 Introducing anatomical concepts to junior A359 962.7 Insertion of a functional copy of six2 into the high school students: early engagement. T. Franz-Odendaal. mouse genome to examine prenatal morphogenetic factors Mount Saint Vincent Univ., Canada. leading to chronic renal failure in the adult. C. Chang, Z. A348 961.4 Learning by teaching: service learning in Stoytcheva, J. Marh, J. Dee, B. Fogelgren, S. Lozanoff and anatomy. J.M. Montante, R. Nazar and M. Bee. Oakland Univ. S. Moisyadi. John A. Burns Sch. of Med., Univ. of Hawaii. William Beaumont Sch. of Med. and Univ. of Detroit Mercy. A349 961.5 MedStart: a hands-on anatomical experience 963. DEVELOPMENT AND GROWTH: CRANIOFACIAL for middle school students. B.M. Laitman, A. Witkin, A. Parikh, A. Armstrong, S. Zuckerman, R. Bhattacharya, E. Chu, M. Poster Schneiderman, A-G. Palermo, S.H. Factor, J.S. Reidenberg and J.T. Laitman. Mount Sinai Sch. of Med. Tue. 7:30 am—Boston Convention & Exhibition Center, A350 961.6 Emphasis placed on active learning in Exhibit Halls A-B remodeling the histology course in the prematriculation summer Presentation time: 12:30 pm-2:00 pm program for entering medical and dental students. A.M. Stefan. Med. Col. of Georgia at Georgia Regents Univ. A360 963.1 Early craniofacial bone growth and maturation A351 961.7 Evaluation of student participation and of Fgfr2+/P253R mice and littermates. C. Percival, T. Pankratz, Y. perceptions of a neuroscience community outreach project. J. Huang, X. Zhou, E.W. Jabs, R. Li and J.T. Richtsmeier. Penn Neal and B. Puder. California Sch. of Podiat. Med. and Samuel State and Mount Sinai Sch. of Med. Merritt Univ. A361 963.2 Ephrin reverse signaling induces mouse palatal A352 961.8 Medical students applying newly learned fusion and epithelial to mesenchymal transition in cultured anatomy knowledge as part of a mentoring and experiential medial edge epithelia. M.J. Serrano, A. Nawshad, I. Ibrahim, learning environment with undergraduate and elementary J. Dyke, K.K. Svoboda and M.D. Benson. Baylor Col. of Dent. students. C.K. Thang, M. Diaz, J. Padilla, K. Ojukwu, H. Lee, and Col. of Dent., Univ. of Nebraska Med. Ctr. T N. Schmalz and J. Wisco. David Geffen Sch. of Med. at UCLA, A362 963.3 Amphibian muscle development and U UCLA Fielding Sch. of Publ. Hlth. and Brigham Young Univ. homologies: broader developmental and evolutionary E implications, with notes on metamorphosis and terminal 962. DEVELOPMENT AND GROWTH: BIRTH additions. J. Ziermann and R. Diogo. Howard Univ. DEFECTS A363 963.4 The role of BCL11 transcription factors in mouse craniofacial suture development. K. Kyrylkova, U.T. Poster Iwaniec and M. Leid. Oregon State Univ. A364 963.5 Refining the timeline of conjunctival papillae Tue. 7:30 am—Boston Convention & Exhibition Center, induction in the chick scleral ossicle system. K. Jourdeuil and Exhibit Halls A-B T. Franz-Odendaal. Dalhousie Univ. and Mount Saint Vincent Univ., Halifax, Canada. Presentation time: 12:30 pm-2:00 pm A365 963.6 Patterns of morphological integration of the A353 962.1 Analysis of overlapping phenotypes from face in boys with autism spectrum disorders. K. Aldridge, trisomic and euploid embryos of a Down syndrome mouse I.D. George, J.R. Austin, Y. Duan and J.H. Miles. Univ. of model (Ts65Dn): implications for human medicine. N. Bhatia, Missouri-Columbia, Sch. of Med. and Thompson Ctr. for Autism R. Diogo and R. Roper. Howard Univ. and Indiana Univ.- & Neurodevelop. Disorders. Purdue Univ. Indianapolis. A366 963.7 The influence of dentition on the developing mandible in a mouse model. M.A. Holmes. Johns Hopkins Sch. of Med.
325 ANATOMY TUESDAY
964. DEVELOPMENT AND GROWTH: LIMBS 966. DEVELOPMENT AND GROWTH: GENE AND PROTEIN EXPRESSION Poster Poster Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Presentation time: 12:30 pm-2:00 pm Presentation time: 12:30 pm-2:00 pm A367 964.1 Multiscale modeling goes out on a limb: in silico simulations of developmental mechanisms shared between A376 966.1 Insights from transcriptional profiling the somitogenesis and the developing embryonic avian limb bud. mouse hindbrain: novel feedback between retinoids and Hox J.S. Gens, J. Srividhya, J.M. Belmonte, S.D. Hester and J.A. genes. M. Yurieva, B. De Kumar and R. Krumlauf. Stowers Glazier. Indiana Univ. and Univ. of Arizona. Inst. for Med. Res., Kansas City, MO. A368 964.2 A novel role for Tbx3 in regulating digit number A377 966.2 A simple PCR-based strategy for estimating in the developing limb by Shh dependent and independent species-specific contributions in chimeras and xenografts. E.L. mechanisms. U.J. Emechebe, P. Kumar, K. Thomas and A. Ealba and R.A. Schneider. UCSF. Moon. Univ. of Utah and Geisinger Clin., Danville, PA. A378 966.3 LMX1B-regulated nephrogenesis: a role for A369 964.3 Upregulation of sonic hedgehog by fibroblast proteoglycans. A.J. Espinoza, J. Feenstra, C. Pira and K. growth factor: Is TFAP2C a downstream intermediate? A. Oberg. Sch. of Med., Loma Linda Univ. Coggins, C.U. Pira, J.M. Feenstra and K.C. Oberg. Loma A379 966.4 Cold-inducible RNA binding protein in breast Linda Univ. development and disease. R.S. Hartley, S. Garcia, L. Ruan, G. A370 964.4 Testing hypotheses of growth in the developing Herrera, T.A. Mitchell, T. Howard and H.J. Hathaway. Univ. of chicken limb bud. D.A. Fowler, E.B. Searle, C. Button, E.K. New Mexico Hlth. Sci. Ctr. Chan and H.C.E. Larsson. McGill Univ., Canada. A371 964.5 The effects of cyclopamine on the ontogeny of 967. ANATOMICAL BASIS OF DEVELOPMENT fibroblast growth factor 8 mRNA expression during embryonic PATHOGENESIS OF DISEASE development of the chick limb. J. Maze, J. Smith and B. Roche. Lander Univ., SC. Poster 965. DEVELOPMENT AND GROWTH: NEURAL Tue. 7:30 am—Boston Convention & Exhibition Center, CREST AND PLACODES Exhibit Halls A-B Presentation time: 12:30 pm-2:00 pm Poster A380 967.1 The chick embryo neural crest model system Tue. 7:30 am—Boston Convention & Exhibition Center, reveals a unique role for EphB6 in melanoma metastasis. C.M. Exhibit Halls A-B Bailey and P.M. Kulesa. Stowers Inst. for Med. Res., Kansas City, MO. Presentation time: 12:30 pm-2:00 pm A381 967.2 Empirical development of a histological protocol A372 965.1 Evidence for dynamic rearrangements but lack for whole brain sectioning to characterize neuropathological of fate or position. M.C. McKinney, K. Fukatsu, J. Morrison, R. patterns in human specimens. K.M. Chan, N.A. Schmalz, K. McLennan, M.E. Bronner and P.M. Kulesa. Stowers Inst. for Choy, A. Nguyen, T.N. Pham, E. Stark, H. Dong, A.W. Toga, Med. Res., Kansas City, MO and Caltech. H.V. Vinters and J.J. Wisco. David Geffen Sch. of Med. at A373 965.2 germ cell nuclear factor (Gcnf/Nr6a1) plays UCLA and Brigham Young Univ. a novel role in neural crest cell induction. A. Achilleos, J. A382 967.3 Quantitative co-localization of hyaluronic acid Dennis, S. Bhatt, D. Sakai and P. Trainor. Stowers Inst. for and damaged myelin in the aging rhesus monkey brain. L.I. Med. Res., Kansas City, MO. Estrada, P. Boule-Getsinger, E. Witkowski, F. Mortazavi and A374 965.3 Using the antiphosphatase paladin to D.L. Rosene. Boston Univ. Sch. of Med. understand the phosphoregulation of neural crest development. A383 967.4 Understanding craniofacial variability caused J. Roffers-Agarwal, K.J. Hutt and L.S. Gammill. Univ. of by loss of Gata3 function. J.K. Eberhart and M.E. Swartz. Minnesota, Minneapolis and Prince Henry’s Inst., Clayton, Univ. of Texas at Austin. Australia. A384 967.5 Characterization of the avian Talpid2 mutant. A375 965.4 Expression and function of tenascin-C during S.A. Brugmann, C-F. Chang, E.N. Schock, J. Snyder and colorectal enteric nervous system development. N. Nagy, M.E. Delany. Cincinnati Children’s Hosp. Med. Ctr. and Univ. of S. Akbareian, C. Steiger, D. Molnar, C. Barad and A.M. California, Davis. Goldstein. Semmelweis Univ. Fac. of Med., Hungary and A385 967.6 Three-dimensional reconstructions of human Massachusetts Gen. Hosp., Harvard Med. Sch. embryos: morphogenesis and hepatic vascularization. M. Lhuaire, E. Scharbarg, É. Micard, R. Cendre, V. Delmas, F. Duparc, P. Mercier, J. Felblinger, M. Braun, C. Avisse and LAST DAY TO VISIT M. Labrousse. Univ. of Reims Champagne-Ardenne, CHU de EXHIBITS Nancy Brabois, René Descartes Univ. Paris V, Rouen Univ., Angers Univ. and Henri Poincaré-Lorraine Univ., Nancy. Tuesday, April 23 A386 967.7 C-jun N-terminal kinase maintains tissue integrity during cell rearrangement in the gut. N. Nascone- 9:00 AM – 4:00 PM Yoder and M. Dush. Col. of Vet. Med., North Carolina State Univ.
326 TUESDAY ANATOMY/BIOCHEMISTRY
A387 967.8 Syntaxin 16 is required for epithelial A389 967.10 Reducing parathyroid hormone is essential for morphogenesis and single lumen formation. J-J. Jung, S.M. correcting cortical bone deficiencies associated with chronic Inamdar, A. Tiwari, D. Ye, F. Lin and A. Choudhury. Univ. of kidney disease. C. Newman, S.M. Moe, N.X. Chen, D.M. Iowa. Brown, V.H. Gattone and M.R. Allen. Indiana Univ. Sch. of A388 967.9 microRNA-26b represses colon cancer Med. cell proliferation by inhibiting lymphoid enhancer factor 1 expression. Z. Sun, Z. Zhang, X. Li and B. Amendt. Univ. of Iowa.
Biochemistry and Molecular Biology
968. MECHANISMS OF GENOMIC STABILITY C11 969.6 Role of salicylic acid in chromatin modification and remodeling. D. Kumar, M.I. Haq, T.A. Hotz, M.A. Hossain, Poster B. Zhao and D. Donald. East Tennessee State Univ. C12 969.7 Transcription factor Sp1 promotes chromatin Tue. 7:30 am—Boston Convention & Exhibition Center, remodeling at DNA double-strand breaks. K. Beishline, S. Exhibit Halls A-B Koduri and J. Clifford. Drexel Univ. Col. of Med. Presentation time: 12:25 pm-1:55 pm 970. CHROMOSOME REARRANGEMENTS C1 968.1 Role of Ku in the DNA damage response activated from telomeres. V. Fell and C. Schild-Poulter. Univ. Poster of Western Ontario and Robarts Res. Inst., London, Canada. C2 968.2 Activity and frequency of the ITPA P32T variant Tue. 7:30 am—Boston Convention & Exhibition Center, among colorectal patients. C. Brown. Wayne State Col. Exhibit Halls A-B C3 968.3 Chromosome fragile sites signature and genome instability in human epithelial cells. S.A. Hosseini, J.C. Presentation time: 12:25 pm-1:55 pm Saldivar, S. Horton, J. Sun, N.A. Heerema and K. Huebner. C13 970.1 Analyzing the effects of sub-optimal doses The Ohio State Univ. Wexner Med. Ctr. of raltegravir on HIV-1 integration. J. Varadarajan, M.J. C4 968.4 Coordinated degradation of replisome McWilliams, D. Hazuda and S. Hughes. NCI, NIH, Frederick components ensures genome stability upon replication stress. and Merck Res. Labs., West Point, PA. E. Noguchi, L. Roseaurlin and T. Toda. Drexel Univ. Col. of Med. and Cancer Res. UK, London. 971. GENOME DIVERSITY AND DNA C5 968.5 Effect of high copy retrotransposon insertions RECOMBINATION on yeast genome stability. C. Lanzillotta and L.Z. Scheifele. Loyola Univ. Maryland. Poster
969. CHROMATIN MODIFICATIONS AND Tue. 7:30 am—Boston Convention & Exhibition Center, REMODELING IN DNA REPLICATION, Exhibit Halls A-B RECOMBINATION AND REPAIR Presentation time: 12:25 pm-1:55 pm
Poster C14 971.1 Large-scale structural variations linked to the NOTCH4 locus of the human major histocompatibility complex. T Tue. 7:30 am—Boston Convention & Exhibition Center, J.D. Bowman, B. Zhou, C-y. Yu and S.K. Lawrance. Otterbein U Exhibit Halls A-B Univ., OH and Nationwide Children’s Hosp. E C15 971.2 Determination of the extent of hybridization Presentation time: 12:25 pm-1:55 pm between the threatened Hibiscus dasycalyx, Hibiscus laevis, C6 969.1 Chromatin dynamics and the Fanconi anemia and Hibiscus moscheutos using ISSR genetic markers. L.M. DNA damage response pathway. K.L. Neira, M. Mauro and Baker and B. Clack. Stephen F. Austin State univ. N.G. Howlett. Univ. of Rhode Island. C7 969.2 DNA damage repaired by the base excision 972. MECHANISM OF DNA RECOMBINATION repair pathway is epigenetic. P.R. Strauss, K. Toomire and S.P.G. Moore. Northeastern Univ. Poster C8 969.3 Dynamics of yeast histone H2A and H2B phosphorylation in response to a double-strand break. C-S. Tue. 7:30 am—Boston Convention & Exhibition Center, Lee, K. Lee, J.E. Haber and G. Legube. Brandeis Univ., Exhibit Halls A-B CNRS, Toulouse and Univ. of Toulouse. Presentation time: 12:25 pm-1:55 pm C9 969.4 Nucleosome dynamics regulate DNA processing. N. Adkins, H. Niu, P. Sung and C. Peterson. Univ. C16 972.1 Isolation and characterization of isopentenyl- of Massachusetts Med. Sch. and Yale Univ. Sch. of Med. diphosphate isomerase from marine bacterium, Kocuria C10 969.5 ATP-dependent heterochromatin remodeling. gwangalliensis. T.H. Jeong, K. Ji, N.Y. Jang, Y.S. Cho and Y.T. B.J. Manning and C. Peterson. Grad. Sch. of Biomed. Sci., Kim. Pukyong Natl. Univ., South Korea. Univ. of Massachusetts Med. Sch.
327 BIOCHEMISTRY TUESDAY
973. MECHANISM OF DNA RECOMBINATION C27 975.5 A novel series of antitumor ruthenium beta- diketonato compounds. J. Matthews, F. Caruso, C. Pettinari, Poster F. Marchetti, R. Pettinari, M. Cariboldi and M. Rossi. Vassar Col. and Univ. of Camerino and Univ. of Insubria, Italy. Tue. 7:30 am—Boston Convention & Exhibition Center, C28 975.6 Investigation of riboflavin binding to DNA using Exhibit Halls A-B polymerase chain reaction. M. Banco and M.A. Benore. Univ. Presentation time: 12:25 pm-1:55 pm of Michigan at Dearborn. C29 975.7 A novel CUGexp·MBNL1 inhibitor with C17 973.1 Pch2 is a meiotic hexameric ATPase that binds therapeutic potential for myotonic dystrophy type 1. A.H. to and alters Hop1 functions. C. Chen, A. Jomaa, J. Ortega Jahromi and S.C. Zimmerman. Univ. of Illinois, Urbana. and E. Alani. Cornell Univ. and McMaster Univ., Canada. C30 975.8 DNA-nuclear protein interactions around -224 C18 973.2 Molecular delineation of BubR1 kinase function A/G single nucleotide polymorphism in the neuropeptide in kinetochore microtubule attachments. H. Jiang, Y. Huang, X. receptor Y2 (NPY2R) gene in predisposition to hypertension. Ding and X. Yao. Anhui Key Lab. of Chem. Biol., Heifei, China, E.M. Albino-Rodriguez, T. Katsuya, A. Deng and J. Dutil. Beijing Univ. of Chinese Med. and Morehouse Sch. of Med. Ponce Sch. of Med., PR, Osaka Univ. Grad. Sch. of Med. and Univ. of Montreal Res. Ctr. CHUM. 974. MUTAGENESIS 976. TRANSLESION AND ERROR-PRONE DNA Poster POLYMERASES Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Poster
Presentation time: 12:25 pm-1:55 pm Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B C19 974.1 ENU-induced mutagenesis in grass carp (Ctenopharyngodon idellus) by treating mature sperm. S-M. Presentation time: 12:25 pm-1:55 pm Zou and X-Y. Jiang. Shanghai Ocean Univ. C31 976.1 Functional studies of point mutation G295R on C20 974.2 Evaluation of oxidative DNA damage, lipid the catalytic core of human DNA polymerase h. A.J. Valdez, M. peroxidation and antioxidant status in patients undergoing Kumar and X. Jiang. Tennessee Technol. Univ. surgery with sevoflurane anesthesia.M.G. Braz, J.E.B. Orosz, C32 976.2 Site-directed mutagenesis, expression, D.T. Pierine, L.G. Braz, A.L.A. Ferreira, D.M.F. Salvadori, purification and translesion synthesis analysis of human DNA K-J. Yeum and J.R.C. Braz. São Paulo State Univ., Botucatu polymerase h mutations found in xeroderma pigmentosum and USDA at Tufts Univ. variant and melanoma patients. M. Kumar and X. Jiang. C21 974.3 Improvement of P. chrysogenum by UV Tennessee Technol. Univ. mutation for overproduction of cellulase and ligninase. O.M. C33 976.3 Werner’s syndrome protein limits the error- Babalola, , M.O. Abiola, E.O. Albert, I.O. Ngozi and E.N. prone 8-oxo-G lesion bypass activity of human DNA polymerase Miriam. Univ. of Lagos, Nigeria. kappa by promoting the error-free bypass. L. Maddukuri, S.D. C22 974.4 Monitoring the expression and activity of the Eddy and R.L. Eoff. Univ. of Arkansas for Med. Sci. DinB protein in vivo in Escherichia coli. B.H. Diamond and V. C34 976.4 Regulation of DNA damage tolerance by the Godoy-Carter. Northeastern Univ. AhR pathway and its role in glioma progression. A. Bostian and R. Eoff. Univ. of Arkansas for Med. Sci. 975. NUCLEIC ACID- SMALL MOLECULE C35 976.5 Overexpression of human polymerase n in E. INTERACTIONS coli. S.C. Shissler and X. Jiang. Tennessee Technol. Univ., Oak Ridge and Cookeville. Poster C36 976.6 Replication of G-quadruplexes by archaeal DNA polymerases. S.D. Eddy, L. Maddukuri and R.L. Eoff. Tue. 7:30 am—Boston Convention & Exhibition Center, Univ. of Arkansas for Med. Sci. Exhibit Halls A-B C37 976.7 Antibiotic resistance acquired through a DNA Presentation time: 12:25 pm-1:55 pm damage-inducible response in Acinetobacter baumannii. M.D. Norton and V.G. Godoy. Northeastern Univ. C23 975.1 Structural characterization of the major DNA- DNA cross-link formed by epichlorohydrin. K. Sirka and J.T. Millard. Colby Col., ME. 977. TRANSPOSITION C24 975.2 Mechanisms of cytotoxicity of bifunctional epoxide cross-linking agents. A. Spierer and J.T. Millard. Poster Colby Col., ME. Tue. 7:30 am—Boston Convention & Exhibition Center, C25 975.3 Amplification of human DNA for probing DEB- Exhibit Halls A-B induced damage via a quantitative polymerase chain reaction. E. Chuang and J.T. Millard. Colby Col., ME. Presentation time: 12:25 pm-1:55 pm C26 975.4 The role of microRNA-208a in cardiac C38 977.1 Cooperative role of MMP-3 and HP1 in heat hypertrophy induced by aerobic physical training. U.P.R. Soci, shock protein transcription. T. Eguchi and S. Calderwood. T. Fernandes, K.T. Rosa, M.C. Irigoyen, M.I. Phillips and Beth Israel Deaconess Med. Ctr., Harvard Med. Sch. E.M. de Oliveira. Sch. of Phys. Educ. and Sports and INCOR- FMUSP, São Paulo and Keck Grad. Inst., Claremont, CA.
328 TUESDAY BIOCHEMISTRY
978. CHROMOSOMES C48 980.7 Characterization of lysine-specific demethylase 1 as a potential olfactory receptor regulator. A.L. Savarino, S. Poster Kilinc and R. Lane. Wesleyan Univ. C49 980.8 Extra-transcriptional effects of RNA polymerase Tue. 7:30 am—Boston Convention & Exhibition Center, III transcription complex on neighboring RNA polymerase II Exhibit Halls A-B transcribing genes in Saccharomyces cerevisiae. A. Korde, Presentation time: 12:25 pm-1:55 pm J.M. Rosselot and D. Donze. LSU. C50 980.9 The Ure2 acap is required for GATA factor C39 978.1 HU decreases diffusible supercoiling density responses to rapamycin, but not nitrogen limitation. J.J. Tate, in bacterial chromosome. A.A. Agbleke, N. Rovinskiy, A. Feller, I. Georis, E. Dubois and T.G. Cooper. Univ. of O. Chesnokova and P.N. Higgins. Univ. of Alabama at Tennessee Hlth. Sci. Ctr., Memphis and Univ. Libre of Brussels. Birmingham. C51 980.10 Study on the neurogenic mechanisms of C40 978.2 Cohesin-dependent association of tRNA traumatic brain injury. H. Duan, Y. Fan, C. Hao, S. Li, S. Wang, genes with nuclear pore complexes in budding yeast. M. Chen H. Wang, D. Kuai, S. Lian and N. Xue. First Clin. Col. of Shanxi and M.R. Gartenberg. UMDNJ-Robert Wood Johnson Med. Med. Univ., China. Sch. 981. EPIGENETICS: HISTONE AND DNA 979. MITOTIC SPINDLE MODIFICATIONS Poster Poster Tue. 7:30 am—Boston Convention & Exhibition Center, Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Exhibit Halls A-B Presentation time: 12:25 pm-1:55 pm Presentation time: 1:05 pm-2:35 pm C41 979.1 Aurora-A-elicited astrin phosphorylation C52 981.1 The role of neuropeptide Y and aquaporin 4 in regulates mitotic progression. S-C. Chiu, J-M.M. Chen, M-C. the pathogenesis of intestinal dysfunction caused by traumatic Liu and C-T.R. Yu. China Med. Univ., China Med. Univ. Hosp. brain injury. H. Duan, C. Hao, S. Li, Y. Fan, H. Wang, J. Hao, Y. and Natl. Chi Nan Univ., Taiwan. Liu and X. Liu. The First Clin. Col. of Shanxi Med. Univ., China. C53 981.2 MeCP2_e2 does not contribute Rett syndrome 980. MECHANISMS OF GENE TRANSCRIPTION AND phenotypes but essential for placenta. M. Itoh, C.G.T. Tahimic, REGULATION II Y-i. Goto and A. Kurimasa. Natl. Ctr. of Neurol. and Psychiat., Kodaira and Tottori Univ., Japan. Poster C54 981.3 Epigenetic markers in patients with endometriosis. K.L. Ray, M. Isme, C. Cook, M. Massie, B. Tue. 7:30 am—Boston Convention & Exhibition Center, Dawley and N. Santanam. Marshall Univ. and Bluefield State Exhibit Halls A-B Col., WV. Presentation time: 1:05 pm-2:35 pm C55 981.4 Epigenetic changes in human cells exposed to X-rays. M.A. Chaudhry and R.A. Omaruddin. Univ. of Session I scheduled on Monday. Vermont. C42 980.1 Function of CDK8 submodule and TRIM28 C56 981.5 IGF1 growth hormone response element in transcriptional regulation at HSPA1B. H. Bunch and S. undergoes developmentally regulated demethylation Calderwood. Beth Israel Deaconess Med. Ctr., Harvard Med. independent of STA5b. R.A. McKnight, J. Wiedmeier, X. Yu, Sch. C.W. Callaway and R.H. Lane. Univ. of Utah. T C43 980.2 The QA repeat domain of TCERG1 plays a role C57 981.6 High fat diet induced genome-wide differential in inhibiting C/EBPa and in its ability to undergo redistribution methylation affecting hepatic signaling pathways in rat. Y. U in the nucleus. W.J. Roesler, N. Miller, N. Timchenko and B. Zhang, D. Zhou, J. Ma, Y-X. Pan and H. Chen. Univ. of Illinois E Moazed. Univ. of Saskatchewan and Baylor Col. of Med. at Urbana-Champaign. C44 980.3 Transcriptional regulator MftR from C58 981.7 The detection of 5-hydroxymethylcytosine in Burkholderia thailandensis participates in oxidative stress Trypanosoma brucei DNA. E. Valentine, R. Smindak and K.T. responses. A. Gupta and A. Grove. LSU. Militello. SUNY at Geneseo. C45 980.4 Regulation of CFTR gene expression by C59 981.8 Replication and transcription of SV40 direct recruitment of an intestinal transcription factor network. J. distinct epigenetic signaling. B. Milavetz, L. Kallestad, A. Kerschner and A. Harris. Children’s Hosp. of Chicago Res. Gefroh, E. Woods and K. Christensen. Univ. of North Dakota. Ctr. and Northwestern Univ. Feinberg Sch. of Med. C60 981.9 Regulation of the DNA-binding protein CFP1 C46 980.5 Identify PCBP1-interacting protein and its by ERK1/2. A.M. Klein, S. Earnest and M.H. Cobb. Univ. of novel functional role on human MOR gene expression. P. Texas Southwestern Med. Ctr. Nahar-Gohad, H. Sultan, Y. Esteban, A. Stabile and J. Ko. Seton Hall Univ. C47 980.6 Effects of recognition sequence variations on transcription regulation of multidrug resistance regulator Pdr1p in yeast. N. Nishida, K. Kuroda and M. Ueda. Kyoto Univ. Grad. Sch. of Agr.
329 BIOCHEMISTRY TUESDAY
982. HETEROCHROMATIN 985. FRONTIERS IN RNA BIOLOGY
Poster Poster
Tue. 7:30 am—Boston Convention & Exhibition Center, Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Exhibit Halls A-B
Presentation time: 1:05 pm-2:35 pm Presentation time: 1:05 pm-2:35 pm C61 982.1 Sirtuins mediate cohesion of silenced domains C69 985.1 Inhibition of HIV-1 transcription by a tunable in Saccharomyces cerevisiae. Y-F. Chen and M. Gartenberg. chimeric tRNA(Ser)-nucloelar localizing trans-activation UMDNJ-Robert Wood Johnson Sch. of Med. response element decoy. C. Stevens, L. Scherer, J. Rossi and K. Haushalter. Harvey Mudd Col., CAand Beckman Res. Inst., 983. NON-CODING RNAS IN GENE REGULATION Duarte, CA. AND CHROMOSOME STRUCTURE 986. RIBOSOME AND TRANSLATION Poster Poster Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Presentation time: 1:05 pm-2:35 pm Presentation time: 1:05 pm-2:35 pm C62 983.1 Identification of SCAL1, a novel long non- coding RNA, induced by cigarette smoke and associated with C70 986.1 The disassembly of post-termination complex lung cancer. P. Thai, S. Statt, E. Liang, C. Campbell and R. by ribosome recycling factor and EF-G occurs first with the Wu. Univ. of California, Davis. releases of tRNA, mRNA, and splitting of the ribosome in its order – IF3 does not participate in this reaction. A. Kaji, N. 984. RECOMBINANT DNA TECHNOLOGY Iwakura and H. Kaji. Univ. of Pennsylvania Sch. of Med. and Thomas Jefferson Univ. Kimmel Cancer Ctr. Poster C71 986.2 Actin bundling mutants in translation elongation factor 1A induce altered protein synthesis at both the initiation Tue. 7:30 am—Boston Convention & Exhibition Center, and elongation steps. W.B. Perez and T.G. Kinzy. UMDNJ- Exhibit Halls A-B Robert Wood Johnson Med. Sch. C72 986.3 Cloning and characterization of leucyl-tRNA Presentation time: 1:05 pm-2:35 pm synthetase from Pseudomonas aeruginosa. E. Medellin, H. C63 984.1 A biologist’s resource for protein expression Salazar, N. Quach, P. Chavero and J. Bullard. Univ. of Texas plasmids: the Protein Structure Initiative:Biology-Materials -Pan American. Repository. C. Cormier, J. Park, M. Fiacco, J. Steel, P. Hunter C73 986.4 Enzymatic analysis of EF-Tu and EF-Ts from and J. LaBaer. Biodesign Inst., Arizona State Univ. Pseudomonas aeruginosa. A. Tran, S. Palmer and J. Bullard. C64 984.2 Vaccination of BALB/c mice against a murine Univ. of Texas-PA. hookworm model. M.W. Schlotterback, P. Comella, C. Horien, C74 986.5 Cloning and characterization of EF-Tu and EF- K. Neutzling, K. Luk, E. Richards and J. Pearson. Concordia Ts from Bacillus subtilis. C. Rivera, V. Garcia and J. Bullard. Col., MN. Univ. of Texas-PA. C65 984.3 Innovative immunological assays for diagnosis C75 986.6 Evolution of ribosomal RNA: universal and of Schistosoma mansoni for clinical acute and/or chronic forms. domain-specific conserved sequences. S.A. Gerbi, S.M. Doris, R.F.G. Queiroz, D. Harn and P.M. Coelho. Fiocruz, Belo D. Smith, B. Raphael, J. Beamesderfer and J. Nathanson. Horizonte, Brazil and Univ. of Georgia. Brown Univ. C66 984.4 Large-scale expression and purification of C76 986.7 Widespread regulation of translation by active pseudolysin in Escherichia coli. R.S. Tarpley, O.A. elongation pausing in heat shock. R. Shalgi, S. Lindquist and Adekoya, I. Sylte and O.O. Odunuga. Stephen F. Austin State C.B. Burge. MIT and Whitehead Inst. for Biomed. Res. Univ., TX and Univ. of Tromsø, Norway. C77 986.8 Primary and alternative S18 ribosomal protein C67 984.5 Novel method for the scarless single-step in Mycobacterium tuberculosis. S. Prisic and R.N. Husson. assembly of many small DNA sequences. T.L. Roth, L. Boston Children’s Hosp./Harvard Med. Sch. Milenkovic and M. Scott. Stanford Univ. C68 984.6 Synthetic biology and the production from 987. RNA EDITING AND MODIFICATION Brazilian spider silk protein Masp1 in E. coli system. V.A. Michalczechen-Lacerda, P.F. Oliveira, G.R. Vianna, A.M. Poster Murad, D.L. Kaplan and E. Rech. Tufts Univ. and Univ. of Brasilia. Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B
Presentation time: 1:05 pm-2:35 pm C78 987.1 Characterization of putative mitochondrial processing peptidase a-subunit in Trypanosoma brucei. I.L. Mak, Z. Lu, V.N. Mehta and R. Salavati. McGill Univ.
330 TUESDAY BIOCHEMISTRY
988. RNA PROCESSING 991. RNA TRANSPORT AND LOCALIZATION
Poster Poster
Tue. 7:30 am—Boston Convention & Exhibition Center, Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Exhibit Halls A-B
Presentation time: 1:05 pm-2:35 pm Presentation time: 1:05 pm-2:35 pm C79 988.1 Structural insights into RNase T in RNA C87 991.1 Regulation of mRNA export by the PI3 kinase/ maturation and DNA repair. H.S. Yuan, Y-Y. Hsiao and W-C. AKT signaling pathway. E.A. Vancor, A.J.C. Quaresma and Chu. Inst. of Molec. Biol., Acad. Sinica, Taipei and Natl. Yang- J.A. Nickerson. Univ. of Massachusetts Med. Sch. Ming Univ., Taiwan. C80 988.2 Investigation of functionally critical residues 992. RNA TURNOVER in the pseudo-helicase domain of Brr2. D. Anguiano, C.M. Brittsan, J.K. Titus, W. Boswell, C. Guthrie and C. Maeder. Poster Texas State Univ.-San Marcos and UCSF. C81 988.3 Comprehensive mechanistic analysis of the Tue. 7:30 am—Boston Convention & Exhibition Center, RNA-lariat debranching enzyme. E.M. Ransey, S. Dey, S. Das Exhibit Halls A-B
and M. Macbeth. Carnegie Mellon Univ. Presentation time: 1:05 pm-2:35 pm C82 988.4 Alternative substrate kinetics of Escherichia coli ribonuclease P: determination of relative rate constants C88 992.1 A stress-activated, p38 MAPK-ATF/CREB by internal competition. L.E. Yandek, H-C. Lin and M. Harris. pathway regulates the post-transcriptional decay of target Case Western Reserve Univ. mRNSs. J. Gao, J.L. Wagnon, R.M. Protacio, G.V. Glazko, C83 988.5 Insights into splicing: structure of the yeast M. Beggs, V. Raj, M.K. Davidson and W.P. Wahls. Univ. of U1 snRNP. C. van der Feltz, N. Grigorieff and D. Pomeranz Arkansas for Med. Sci. Krummel. Brandeis Univ. and HHMI, Chevy Chase, MD. 993. REGULATORY THIOL MODIFICATIONS 989. RNA STRUCTURE AND DYNAMICS Poster Poster Tue. 7:30 am—Boston Convention & Exhibition Center, Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Exhibit Halls A-B Presentation time: 1:05 pm-2:35 pm Presentation time: 1:05 pm-2:35 pm C89 993.1 Turnabout is fair play: mutual regulation of C84 989.1 Molecular dynamics study of the stability of the palmitoylation and raft partitioning. I. Levental and K. Simons. sarcin/ricin domain of RNA. M.F. Bruist and C. Cavanaugh. Univ. of Texas Hlth. Sci. Ctr. at Houston and Max Planck Inst. of Univ. of Sciences in Philadelphia. Cell Biol. and Genet., Dresden. C85 989.2 Conformational stability of loop E in the potato C90 993.2 A redox insensitive triple cysteine mutant of spindle tuber viroid. R.M. Salvo, M.F. Bruist and T. Baumstark. SirT1 rescues oxidative stress-induced apoptosis. D. Shao, Univ. of Sciences, Philadelphia and Cornell Univ. J. Fry, R. Zee, V. Kumar, D. Pimentel, R. Cohen and M. Bachschmid. Boston Univ. 990. RNA STRUCTURE, FUNCTION AND C91 993.3 Modulation of signaling proteins by reversible cysteine modification. J.D. Keyes, K. Nelson, D. Parsonage, REGULATION L. Daniel, C. Furdui and L. Poole. Wake Forest Univ. T C92 993.4 Oxidation of the Hsp70 BiP protects cells Poster U during ER stress. C. Sevier, K. Pareja and J. Wang. Cornell E Tue. 7:30 am—Boston Convention & Exhibition Center, Univ. Exhibit Halls A-B 994. AUTOPHAGY Presentation time: 1:05 pm-2:35 pm C86 990.1 The amyotrophic lateral sclerosis and Poster frontotemporal dementia-associated C9ORF72 r(GGGGCC)n hexanucleotide repeat forms extremely stable uni- and multi- Tue. 7:30 am—Boston Convention & Exhibition Center, molecular RNA G-quadruplex structures. K. Reddy, B. Zamiri, Exhibit Halls A-B S. Stanley, R. Macgregor and C. Pearson. The Hosp. for Sick Presentation time: 1:05 pm-2:35 pm Children and Univ. of Toronto. C93 994.1 Role of HSF1 and FoxO3 in proteotoxic stress induced macroautophagy. A. Murshid, S.D. Chou, T. Eguchi and S. Calderwood. Beth Israel Deaconess Med. Ctr., Harvard Med. Sch. C94 994.2 Failure of autophagy induction makes multidrug resistant cells vulnerable to BH3-mimetic gossypol. J-H. Ahn, G-H. Jang and M. Lee. Univ. of Incheon, South Korea.
331 BIOCHEMISTRY TUESDAY
C95 994.3 Mitophagy as a quality control mechanism in 996. PROTEIN FOLDING, MISFOLDING AND Saccharomyces cerevisiae. H. Abeliovich, M. Zarei, K.T.G. AGGREGATION Rigbolt, R.J. Youle and J. Dengjel. Hebrew Univ. of Jerusalem, Freiburg Inst. for Adv. Studies, Germany and NINDS, NIH. Poster C96 994.4 The role of enhanced autophagy in acquired resistance to new B-Raf inhibitor UI-152. G-H. Jang, J-H. Ahn Tue. 7:30 am—Boston Convention & Exhibition Center, and M. Lee. Univ. of Incheon, South Korea. Exhibit Halls A-B C97 994.5 Effects of aging on the heat shock response Presentation time: 1:05 pm-2:35 pm and autophagy in human peripheral blood mononuclear cells. K.R. Lanphere, S. Schneider, C. Mermier, M. Zuhl, K. C110 996.1 Dual role of the metalloprotease FtsH in Dokladny and P. Moseley. Univ. of New Mexico. biogenesis of the DrrAB drug transporter. W. Li. Georgia State C98 994.6 B19, a novel monocarbonyl analogue of Univ. curcumin induced human ovarian cancer cells apoptosis C111 996.2 Detection of pathological tau conformers in via activation endoplasmic reticulum stress and autophagy cerebrospinal fluid.Z.M. March, S. Gupta and D.W. Colby. signaling pathway. J. Xiao, W. Qu, Z. Wang, H. Shi and H. Univ. of Delaware and Indian Inst. of Technol.-Gandhinagar. Zhang. Wenzhou Med. Col., China. C112 996.3 Antiparallel b structure in Ab42 oligomers. L. C99 994.7 The effect of HSF-1 and HSP70 on autophagy Gu, C. Liu and Z. Guo. UCLA. regulation. K. Dokladny, V. Deretic and P.L. Moseley. Univ. of C113 996.4 Probing molecular mechanism of New Mexico. destabilization and misfolding of human apolipoprotein A-I C100 994.8 Effect of a six week exercise training program in familial amyloidosis. M. Das, X. Mei, D. Atkinson and O. on proteolytic enzyme activity, ROS generation and autophagy Gursky. Boston Univ. Sch. of Med. in the white gastrocnemius and left ventricle of normotensive C114 996.5 Structural and functional importance of third- and hypertensive rats. E.M. McMillan, M-F. Paré and J. circuit hydrogen bonds within hemolysin A. M.A. Apolinario Quadrilatero. Univ. of Waterloo, Canada. and T.M. Weaver. Univ. of Wisconsin-La Crosse. C101 994.9 A protocol for screening of autophagy C115 996.6 Hydrazines as potential anti-amyloidogenic regulatory genes applying cell sorting and next-generation agents. S. Ghosh , C. Schifone, M. Foster, B. Torok, H. Levine sequencing technologies. W-P. Huang and A-Y. Liu. Natl. III and M. Torok. Univ. of Massachusetts Boston and Univ. of Taiwan Univ. Kentucky. C116 996.7 Synthesis of functional proteins via 995. PROTEASES IN CELL REGULATION AND bioconjugation. M. Pirigyi and N.J. Zondlo. Univ. of Delaware. C117 996.8 Isoflurane preconditioning involves the DISEASE upregulation of aquaporin genes. Z. Schwamb, N. Seidler and C. Theisen. Kansas City Univ. of Med. and Biosci. Poster C118 996.9 The circulating molecular chaperone clusterin Tue. 7:30 am—Boston Convention & Exhibition Center, interacts with amyloidogenic transthyretin oligomers and Exhibit Halls A-B modulates amyloid formation. M.J. Greene, E. Klimtchuk, C. Koch, D. Seldin and L.H. Connors. Boston Univ. Sch. of Med. Presentation time: 1:05 pm-2:35 pm C119 996.10 A single-molecule fluorescence system for C102 995.1 Expression of recombinant human neutrophil studying adenylate kinase under force. C.A.M. Wilson, S.M. cathepsin G in Pichia pastoris. E.T. Perry, E. Smith and D. Leachman, B. Cervantes, A. Ierokomos, S. Marqusee and Johnson. East Tennessee State Univ. Quillen Col. of Med. C. Bustamante. Univ. of California, Berkeley. C103 995.2 Extracellular thimet oligopeptidase is carried C120 996.11 Structural and kinetic differences in by cell membrane microvesicles of prostate cancer cells. Y. Liu, oligomerization-fibrillation of serum amyloid A and not the L.A. Bruce and A.J. Wolfson. Wellesley Col. intrinsic amyloidogenicity may contribute to pathogenesis in AA C104 995.3 Perillyl alcohol and rapamycin-mediated amyloidosis. S. Srinivasan, S. Patke, J.J. Aguilera, R.S. Kane inhibition of migration and invasion. T. Sundin, P. Mollica, D. and W. Colon. Rensselaer Polytech Inst. Peffley and P. Hentosh. Old Dominion Univ. C121 996.12 Beta-arc 2 hydrogen bond network within C105 995.4 Nuclear MMP-2: presence and activity in hemolysin A facilitates hemolytic activation. E. Glasgow and T. cardiac myocytes. M.Y. Kondo, M.M. Castro, F. Fan and R. Weaver. Univ. of Wisconsin-La Crosse. Schulz. Univ. of Alberta. C122 996.13 Contribution of an inner core hydrogen-bonding C106 995.5 Caspase-1 activation is critical for endothelial network to b-helix stability within the two-partner secretion activation and early atherogenesis. Y. Yin, H. Wang and X-f. exotoxin family. T.M. Weaver. Univ. Wisconsin-La Crosse. Yang. Temple Univ. Sch. of Med. C123 996.14 Production and characterization of oxidation- C107 995.6 The activation of factor VII by a variety of resistant variants of the human ribonuclease inhibitor. A.W. potential activators. K. Ke and J. Morrissey. Univ. of Illinois, Uebersohn and K.A. Dickson. Lawrence Univ., WI. Urbana. C124 996.15 Analysis of the yeast de novo protein C108 995.7 Development of affinity purification systems for YNR034W-A. A. Shi and M. Cordes. Univ. of Arizona. isolation and proteomic analysis of proteases from Tetrahymena C125 996.16 Mortal Kombat: modeling amyloid fibrils and thermophila. B. Lu, J.R. Carreon and J.W. Straus. Vassar health implications. M. Smaoui, F. Poitevin, M. Delarue, P. Col., NY and Ramapo Col., NJ. Koehl, H. Orland and J. Waldispuhl. Sch. of Computer Sci., C109 995.8 RpoS is directly controlled by ATP levels. C. McGill Univ., Inst. Pasteur, Univ. of California, Davis and CEA- Peterson. Suffolk Univ., MA. Saclay, Gif-sur-Yvette, France.
332 TUESDAY BIOCHEMISTRY
C126 996.17 ER stress-independent noncanonical UPR C138 998.8 Ligand binding and conformational change activation under phenformin treatment. L. Yang, H. Sha, Z. Xue coupling in the HAD superfamily. D. Saltzberg, V. Ovchinnikov, and L. Qi. Cornell Univ. D. Dunaway-Mariano, M. Karplus and K. Allen. Boston Univ., Harvard Univ. and Univ. of New Mexico. 997. MASS SPECTROSCOPY 999. MOLECULAR MOTORS - FORCE AND WORK AS Poster PRODUCTS
Tue. 7:30 am—Boston Convention & Exhibition Center, Poster Exhibit Halls A-B Tue. 7:30 am—Boston Convention & Exhibition Center, Presentation time: 1:05 pm-2:35 pm Exhibit Halls A-B C127 997.1 A systematic study of the chemical stress Presentation time: 12:25 pm-1:55 pm response induced by bleach and vinegar in E. coli on viability and protein expression profiles using plating assays and C139 999.1 Plasticity of the kinesin-microtubule interaction matrix-assisted laser desorption ionization Biotyper™ system. is encoded by the motor domain beta-sheet. J. Richard, E. S. Liu and D. Vardar-Ulu. Wellesley Col. Kim, E. Wojcik and S. Kim. LSU Hlth. Sci. Ctr., New Orleans. C128 997.2 Mass spectrometric immunoassay for insulin- C140 999.2 ATPase coupling in the processive RNA like growth factor 1. D. Nedelkov, E. Niederkofler, D. Phillips, helicase NS3 from hepatitis C virus. M.J. Bradley, A. Henn, S. B. Krastins, U. Kiernan, K. Tubbs and M. Lopez. Thermo Ding, A. Pyle and E. De La Cruz. Yale Univ., Technion Israel Fisher Scientific, Tempe, AZ and Cambridge, MA. Inst. of Technol., Sanford-Burnham Med. Res. Inst., La Jolla C129 997.3 Muscle fiber typing by identification of the and HHMI, New Haven. myosin heavy chain using LCMS. J. Kasper, D. Johnson, E. C141 999.3 Unraveling the architecture of the A1 complex Hayes and D. King. Taylor Univ., IN. of the Nanoarchaeum equitans A1A0 ATP synthase. S. C130 997.4 Development of LCMS method for monitoring Mohanty and C.W.V. Hogue. Natl. Univ. of Singapore. the effects of meat feasting, fasting, and exercise on urinary C142 999.4 A search for novel substrate activity in mutants 3MH levels. S. Fenstermacher, K. Cleary, E. Hayes and D. of L-alanine dehydrogenase. H. Aldeborgh and E. Mundorff. King. Taylor Univ. , IN. Vassar Col. and Hofstra Univ. C143 999.5 Electron transfer without metal:. how amino 998. CATALYTIC MECHANISMS acid radicals (mis)behave. W.H. Koppenol, L. Mahmoudi, R. Kissner and T. Nauser. ETH, Zurich. Poster 1000. MACROMOLECULAR FOLDING AND Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B FLUCTUATIONS
Presentation time: 12:25 pm-1:55 pm Poster
C131 998.1 Design and characterization of Thermotoga Tue. 7:30 am—Boston Convention & Exhibition Center, maritima glycerol dehydrogenase to reduce inactivation by Exhibit Halls A-B dihydroxyacetone. P.G. Gross, J. Beauchamp and C. Vieille. Michigan State Univ. Presentation time: 12:25 pm-1:55 pm C132 998.2 The structure, regulation and activity of non- C144 1000.1 Identification of the DNA binding surface on the canonical inteins. K.V. Mills, J.N. Reitter, K.R. Connor, M.C. SIRV capsid protein. H.E. Allgaier, R.E. Taurog, J.E. Johnson, Nicastri, J.E. Williams, K.M. Colelli and M.D. Marieni. Col. of C.E. Rohlman and B.R. Szymczyna. Albion Col., MI, The the Holy Cross. Scripps Res. Inst. and Western Michigan Univ. T C133 998.3 Rational enzyme redesign for enhancing activity U and selectivity of heterologous taxane oxidation in engineered 1001. MOLECULAR MOTOR PROTEINS AND PUMPS E E. coli. V.G. Yadav, S.M. Edgar and G. Stephanopoulos. MIT. C134 998.4 Towards the nitric oxide reductase mechanism Poster of flavodiiron proteins.R. Frederick and D.M. Kurtz. Univ. of Texas at San Antonio. Tue. 7:30 am—Boston Convention & Exhibition Center, C135 998.5 The structural basis of the secondary function Exhibit Halls A-B of PMM1 in the presence of IMP. T. Ji, D. Dunaway-Mariano Presentation time: 12:25 pm-1:55 pm and K.N. Allen. Boston Univ. and Univ. of New Mexico. C136 998.6 Experimental and computational evidence C145 1001.1 Myo1c, an unconventional motor that maintains that ribonuclease A alters the transition state for RNA glomerular filtration function.E. Arif, L. Mallik, Y.S. Rathore, 2’-O-transphosphorylation. M.E. Harris, H. Gu, K-Y. Wong, B. B. Kumari, M. Ostap, F.N.U. Ashish, L.B. Holzman and D. Radak, T. Dissanayake, D. Kellerman, S. Zhang, Q. Dai, M. Nihalani. Univ. of Pennsylvania and CSIR-Inst. of Microbial Miyagi, V.E. Anderson, D. York and J. Piccirilli. Case Western Technol., India. Reserve Univ. Sch. of Med., Rutgers Univ., Piscataway and C146 1001.2 Can a b/delta fusion protein replace individual Univ. of Chicago. b and delta subunits of ATP synthase in Escherichia coli? C.S. C137 998.7 Kinetic mechanism of human DNA ligase I. P.J. Gajadeera and J. Weber. Texas Tech Univ. and Texas Tech O’Brien. Univ. of Michigan Med. Sch. Univ. Hlth. Sci. Ctr.
333 BIOCHEMISTRY TUESDAY
C147 1001.3 Structural model of a2-subunit N-terminus and C156 1004.4 Mutations found in patients Leber’s congenital its binding interface for cytohesin-2: implication for regulation of amaurosis disrupt retinal guanylate cyclase interaction with V-ATPase function. M. Merkulova, H. Hosokawa, A. Bakulina, rhodopsin in vitro; involvement in phototransduction. V.A. P.V. Dip, Y.R. Thaker, A. Khatri, D.A. Ausiello, G. Grüber and Bondarenko and K. Jones. Touro Univ. Nevada and Touro V. Marshansky. Massachusetts Gen. Hosp., Harvard Med. Univ. Nevda Col. of Osteo. Med. Sch., State Res. Ctr. Virol. Biotech., Kolatsovo, Russia and C157 1004.5 New evidence for dimerization of the short Nanyang Technol. Univ., Singapore. variant of PLA2g6, and regulation of its catalytic activity by Ca2+/calmodulin and Ca2+ influx factor.S. Korolev, P. Csutora, 1002. MULTIENZYME COMPLEXES K. Peter, O. Koroleva, P. Subramanya, K. Malley and V.M. Bolotina. Saint Louis Univ. Sch. of Med. and Boston Univ. Sch. Poster of Med. C158 1004.6 Structure-function studies of the ADPglucose Tue. 7:30 am—Boston Convention & Exhibition Center, pyrophosphorylase from Thermodesulfovibrio yellowstonii. M. Exhibit Halls A-B Susoeff, E. Yik, S. Kaur, G. Dua, M. Badal, A. Orry and C.R.
Presentation time: 12:25 pm-1:55 pm Meyer. California State Univ., Fullerton and Molsoft LLC, San Diego. C148 1002.1 C1- tetrahydrofolate synthase contribution to C159 1004.7 Use of recombinent casein peptides as 1C metabolism. D. Blemur , M. Field and P. Stover. Cornell inhibitors of spPEP. S. Basak and B. Clack. Stephen F. Austin Univ. State Univ. C149 1002.2 NMR studies of the N-terminal domains of E2 C160 1004.8 Pyruvate revisited as a synergistic component of human pyruvate dehydrogenase complex. S. secondary activator of the Escherichia coli ADP-glucose Kumaran, B. Birkaya, M. Patel and F. Jordan. Rutgers Univ. pyrophosphorylase. M.A. Ballicora, M. Asención Diez and and Univ. at Buffalo SUNY. A.A. Iglesias. Loyola Univ. Chicago and Natl. Univ. del Litoral, C150 1002.3 Investigation of protein-protein interactions in Argentina. the pyruvate dehydrogenase complex from Escherichia coli by C161 1004.9 The phage e34 repressor binds to a unique hydrogen/deuterium exchange mass spectrometry. J. Wang, operator. J.D. Williams, D. Jackson and R. Villafane. Alabama N.S. Nemeria and F. Jordan. Rutgers Univ., Newark. State Univ. and Huntingdon Col. C151 1002.4 Develop spatially-interactive multienzyme C162 1004.10 The importance of a loop structure in ATP complex on selfassembled DNA nanostructures. J. Fu. apparent affinity and allosteric activation of Escherichia coli Biodesign at Arizona State Univ. ADP-glucose pyrophosphorylase. B.L. Hill, J. Wong, J. Frisby- Zedan, B. May and M.A. Ballicora. Loyola Univ. Chicago. 1003. PROTEIN INTERACTIONS IN CATALYSIS C163 1004.11 Probing the role of E304 in the allosteric site of ADPglucose pyrophosphorylase from Agrobacterium Poster tumefaciens. S. Bor, H. Karzai, K. Chastain, A. Orry and C.R. Meyer. California State Univ., Fullerton and Molsoft LLC, San Tue. 7:30 am—Boston Convention & Exhibition Center, Diego. Exhibit Halls A-B C164 1004.12 Small crosslink may stabilize P22 tail protein at Presentation time: 12:25 pm-1:55 pm N-terminus. C. Palmer, S. Johnson, D. Dean and R. Villafane. Alabama State Univ. and Huntingdon Col. C152 1003.1 Thermodynamics and kinetics of the interactions of calmodulin with Orai. C-C. Wei, S. Shakya, D. Jensen and K. Bennett. Southern Illinois Univ. Edwardsville. 1005. ROLE OF DYNAMICS IN ENZYME CATALYSIS Poster 1004. REGULATION AND ALLOSTERISM Tue. 7:30 am—Boston Convention & Exhibition Center, Poster Exhibit Halls A-B
Tue. 7:30 am—Boston Convention & Exhibition Center, Presentation time: 12:25 pm-1:55 pm Exhibit Halls A-B C165 1005.1 Structural analysis of an intein from an extreme Presentation time: 12:25 pm-1:55 pm thermophile. J.E. Williams, J.N. Reitter and K.V. Mills. Col. of the Holy Cross. C153 1004.1 The allosteric regulation of phenylalanine C166 1005.2 The role of an extended beta-sheet in hydroxylase provides a foundation for new PKU therapies. stabilizing the structure of a thermophilic intein. K.M. Colelli, E.K. Jaffe, L. Stith, S.H. Lawrence, M. Andrake and R.L. J.M. Pusztay, J.N. Reitter and K.V. Mills. Col. of the Holy Dunbrack. Fox Chase Cancer Ctr., Temple Hlth. Cross. C154 1004.2 Probing the effects of cofactor and substrate on conformation and flexibility of human pGDH.C. Roach and E. Bell. Univ. of Richmond. C155 1004.3 Regulation of assembly of bipolar myosin II filaments. A. Kandel, R. Frei and K. Prehoda. Univ. of Florida and Univ. of Oregon.
334 TUESDAY BIOCHEMISTRY
1006. BIOPHYSICAL METHODS 1008. METABOLIC NETWORKS
Poster Poster
Tue. 7:30 am—Boston Convention & Exhibition Center, Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Exhibit Halls A-B
Presentation time: 12:25 pm-1:55 pm Presentation time: 1:05 pm-2:35 pm C167 1006.1 Measurement of urinary catecholamines for C180 1008.1 Metabolic responses of the aerobic anoxygenic mice. E.A. Smith, A.L. Schwartz, T.L. Garrett and J.B. Lucot. phototrophic bacterium Roseobacter denitrificans during Wright State Univ. photoheterotrophic and heterotrophic growth. J.K-H. Tang. C168 1006.2 Novel gold labeling reagent to localize protein Clark Univ., MA. in macromolecular assemblies. K.C. Anthony, C. You, J. Piehler and D. Pomeranz Krummel. Brandeis Univ. and Univ. 1009. METABOLIC REGULATION of Osnabrück, Germany. C169 1006.3 Antibacterial activities of copper, silver and Poster carbon nanoparticles in sock fabric. Y.G. Gete and R. Walker. Metropolitan State Univ. of Denver. Tue. 7:30 am—Boston Convention & Exhibition Center, C170 1006.4 FTIR microspectroscopic analysis of sodium Exhibit Halls A-B
butyrate induced differentiation in colon cancer cells in a time- Presentation time: 1:05 pm-2:35 pm dependent manner. N. Simsek Ozek, S. Gok, S. Banerjee and F. Severcan. Middle East Tech Univ., Turkey. C181 1009.1 Sickle hemoglobin disturbs normal coupling C171 1006.5 Neuronal networks on the nano alumina between erythrocyte O2 content, glycolysis and antioxidant templates. A. Islam. Northeastern Univ. capacity. S.C. Rogers, J. Ross, A. d’Avignon, L. Gibbons, M. Hassan, D. McLaughlin, S. Griffin, T. Neumayr, M. DeBaun, 1007. CYTOCHROME P450 M. DeBaun and A. Doctor. Washington Univ. in St. Louis and Vanderbilt Univ. Poster C182 1009.2 Generation of an inducible arginase-1 deficient mouse model. K. Mukherjee, L.L. Ballantyne, A. Sin, T. St. Tue. 7:30 am—Boston Convention & Exhibition Center, Amand and C.D. Funk. Queen’s Univ., Canada. Exhibit Halls A-B C183 1009.3 Hyperargininemia in an inducible arginase-1- deficient mouse model. A. Sin, L.L. Ballantyne, K. Mukherjee, Presentation time: 12:25 pm-1:55 pm T. St. Amand, C. McCracken, V. Levandovskiy, A. Schulze C172 1007.1 Metoclopramide is a substrate but not an and C.D. Funk. Queen’s Univ., Canada and The Hosp. for Sick inactivator of CYP2D6. A.K. Bolles, E.D. Briggs, M.R. Livezey, Children, Toronto. L.D. Nagy and L.L. Furge. Kalamazoo Col. C184 1009.4 mTOR complex 2 regulation of hepatic gene C173 1007.2 CYP2D6 is the major metabolizing enzyme of expression. J.M. Boylan, D.W. Lamming, N. Neretti, J. metoclopramide. E.D. Briggs, A.K. Bolles, M.R. Livezey and Ferreira, D.M. Sabatini and P.A. Gruppuso. Brown Univ. and L.L. Furge. Kalamazoo Col. Whitehead Inst. for Biomed. Res., Cambridge, MA. C174 1007.3 Interaction of mechanism-based inactivators C185 1009.5 Visualizing the effect of iron on the localization with modified CYP2D6.M.R. Livezey, M.J. Hicks and L.L. of intracellular ferritin in mosquito cells. Z.R. Conley, D. Geiser Furge. Kalamazoo Col. and J. Winzerling. Univ. of Arizona. C175 1007.4 Covalent modification of CYP2D6 following C186 1009.6 Structure of the carnitine palmitoyltransferase- inactivation by SCH66712. M.J. Hicks, M.R. Livezey and L.L. 1A gene in rats, mice and humans. G.A. Cook and E.A. Park. Furge. Kalamazoo Col. Univ. of Hlth. Sci. Ctr. T C176 1007.5 Regio- and stereo-selective oxidation of U fluorinated substrates by recombinant cytochrome P450 BM3 1010. METABOLISM AND DIABETES E variants. S.S-F. Yu, L-L. Wu, C-H. Chiang, R. Ramu, C-L. Yang, K.Y. Ng, W-I. Luo and S.I. Chan. Inst. of Chem., Acad. Sinica, Poster Taipei, Natl. Cheng Kung Univ. and Natl. Taiwan Univ. of Sci. and Technol., Taiwan. Tue. 7:30 am—Boston Convention & Exhibition Center, C177 1007.6 Regulation of phase I and phase II enzyme Exhibit Halls A-B
gene expressions and their activities by caffeic acid, major Presentation time: 1:05 pm-2:35 pm compound of Perilla frutescens. S-Y. Yang, J-H. Kang, H-Y. Jung, J-E. Yang and K-W. Lee. Korea Univ. C187 1010.1 Role of the sphingolipid biostat in pancreatic C178 1007.7 Metabolism of cyclophosphamide by CYP2B6 bcell apoptosis induced by gluco-lipotoxicity. N. Coant, J. Veret, and associated polymorphisms. J.M. Abbott, D. Calinski and P. Giussani, B. Portha, E.V. Berdyshev and H. Le Stunff. P. Hollenberg. Kalamazoo Col. and Univ. of Michigan Med. Univ. Paris Diderot, France, LITA-Segrate, Milan and Univ. of Sch. Illinois at Chicago. C179 1007.8 Cytochrome P450 autophagy: activation by C188 1010.2 Small-molecule modulators of Nkx6.1 acute hepatic heme depletion. Y. Liu and M.A. Correia. UCSF. expression in pancreatic progenitor cells during directed differentiation of human embryonic stem cell to insulin producing beta cells. Q. Peterson and D. Melton. Harvard Univ.
335 BIOCHEMISTRY TUESDAY
C189 1010.3 Elevated hepatic fatty acid elongase-5 1011. MITOCHONDRIA IN HEALTH AND DISEASE attenuates fatty liver in high fat diet induced obese mice. S. Tripathy, R.D. Stevens, J.R. Bain, C.B. Newgard and D.B. Poster Jump. Oregon State Univ. and Duke Univ. Med. Ctr. C190 1010.4 Ultraviolet B radiation enhances glycation of Tue. 7:30 am—Boston Convention & Exhibition Center, human serum albumin and the formation of CML in vitro. W. Exhibit Halls A-B Liu, M.A. Cohenford, L. Frost and J.A. Dain. Univ. of Rhode Presentation time: 1:05 pm-2:35 pm Island and Marshall Univ. C191 1010.5 The dysregulation of AMPK suppresses C204 1011.1 High fat feeding enhances the ability of phosphorylation of sterol regulatory element binding protein mesenchymal stem cell therapy to modulate mitochondria in and increases its activity in the development of atherosclerosis the infarcted heart. C. Hughey, L. Ma, F.D. James, D.P. Bracy, in pig and human diabetes. M. Zang, Y. Li, S. Xu, B. Jiang and D.H. Wasserman, J.N. Rottman and J. Shearer. Univ. of R.A. Cohen. Boston Univ. Sch. of Med. Calgary, Canada and Vanderbilt Univ. C192 1010.6 The miR-696 contributes to insulin resistance C205 1011.2 Aerobic exercise training during pregnancy by reducing mitochondrial function and antioxidant capacity in improves mitochondrial function in human placenta. R. skeletal muscle cells. A.L. Queiroz, T.A. Sousa, B.G. Teodoro, Ramírez-Vélez. Univ. Manuela Beltrán, Colombia. L.M. Bomfim, I.H. Sampaio and L.R. Silveira. Fac. of Med., C206 1011.3 Mitochondrial sensitivity to ADP in Ribeirão Preto-Univ. of São Paulo. permeabilized fibers changed as a function of cardiac muscle C193 1010.7 Mouse models of insulin resistance: what have compartments: left/right atria and ventricles of sheep heart. we learned? A.E. Bunner and N.D. Barnard. Physicians Cmte. M. Chapolard, F. Vaillant, P. Jais, M. Haissaguerre, P. Dos for Responsible Med., Washington, DC. Santos, P. Diolez and V. Deschodt-Arsac. INSERM U1045, C194 1010.8 COMP-Ang1 preserves vasculature and Bordeaux Segalen Univ. prevents vision loss in diabetic retinopathy. J.M. Cahoon, P.R. C207 1011.4 Can perinatal undernutrition alter mitochondrial Olson, X.H. Zhang, M.M. Flood, B. Archer and B.K. Ambati. function and metabolism in the adult liver? C.J. Lagranha, R. Univ. of Utah. Silva-Filho, C. Freitas, A. Silva, L. Nascimento, A.C. Leite, C195 1010.9 Effects of oleate and inflammatory cytokines M.B. Maia and M.P. Fernandes. Fed. Univ. of Pernambuco, on dermal fibroblasts in type 1 diabetics. A.R. Jones IV, J.T. Vitoria de Santo Antão and Recife, Brazil. Deeney and B. Corkey. Boston Univ. Med. Ctr. C208 1011.5 Metformin attenuates cardiomyocyte C196 1010.10 Inhibition of mono-acyl-glycerol lipase by JZL- hypertrophy through mitochondria: reciprocal interaction 184 results in glucolipotoxicity in pancreatic b-cells. C. Berdan, between AMPKk and angiotensin II type 1 receptor. J. Soto- B.E. Corkey and J.T. Deeney. Boston Univ. Med. Ctr. Hernández and S. Javadov. Sch. of Med., Univ. of Puerto C197 1010.11 Chronic exposure of clonal pancreatic b-cells Rico. (INS-1 832/13) to pyruvate inhibits glucose-induced insulin C209 1011.6 Mammalian Ste20-like protein kinase 3 secretion. N.E. Burritt, B. Corkey and J.T. Deeney. Boston mediates the bioenergetics of mitochondria. C-J. Yuan and Med. Ctr. C-Y. Chen. Natl. Chiao Tung Univ., Taiwan. C198 1010.12 Metabolite predictors of HOMA in at-risk for C210 1011.7 Palm fruit juice phenolics reduce the number of mobility disability elderly subjects. M.S. Lustgarten and R.A. mutations caused by 3’-azido-3’-deoxythymidine treatment in a Fielding. Tufts Univ., Boston. cultured human cell line. A. Osborne, A. Stopa, M. Solomon, C199 1010.13 Iron stimulates insulin secretion in clonal L. Wangh and K.C. Hayes. Brandeis Univ. pancreatic b-cells and dissociated rat islets. K.A. Erion, T. C211 1011.8 Dietary avocado oil prevents the impairment Ferrante, B. Corkey and J. Deeney. Boston Univ. Sch. of Med. in the complex III and ROS production in kidney mitochondria C200 1010.14 Cystathionine-g-lyase (CSE) activation and from diabetic rats by improving the electron flow through cytochrome c1. C. Cortes-Rojo, A. Saavedra-Molina, C.A. H2S formation mediate the effect of vitamin D on glucose transporter 4 translocation and glucose utilization in high Samano-Garcia, O. Ortiz-Avila, E. Calderon-Cortes, D. glucose treated 3T3L1 adipocytes. P. Manna and S.K. Jain. Ortiz-Madrigal, G. Hernandez-Mata and A.R. Rodriguez- LSU Hlth. Sci. Ctr., Shreveport. Orozco. Univ. Michoacana of San Nicolas de Hidalgo, Mexico. C201 1010.15 Deficiency of sphingosine kinase 1 ameliorates C212 1011.9 Using in-line probing to characterize pathogenic hepatic steatosis and inflammation in diet-induced obesity.T. mutations in human mitochondrial tRNAs. B. Still, K. Her and Geng, A. Sutter, D. Lewin, J. Ross, K.D. Chavin and L.A. J. Chihade. Carleton Col., MN. Cowart. Med. Univ. of South Carolina. C213 1011.10 Using long-extension PCR assay to detect C202 1010.16 Hypoglycemia increases glycolytic metabolism large-scale deletions in the mitochondrial DNA. W.K. in the rat ventromedial hypothalamus. J. Mun, A. Cooper, J. Pogozelski, S. Chiappone, C. Evans and R. O’Donnell. Cavaretta and J.L. Beverly. Univ. of Illinois, Urbana. SUNY Geneseo. C203 1010.17 Mesenchymal stem cell therapy to promote C214 1011.11 DNA oxidation in regulatory D-loop region of peripheral tissue insulin sensitivity in the high-fat fed, the mitochondrial genome is important for hypoxia-induced myocardial infarcted mouse. C. Hughey, L. Ma, F.D. James, mitochondrial biogenesis in rat pulmonary artery endothelial D.P. Bracy, D.H. Wasserman, J.N. Rottman and J. Shearer. cells. M.V. Ruchko, O.M. Gorodnya, M.N. Gillespie and V.M. Univ. of Calgary, Canada and Vanderbilt Univ. Pastukh. Univ. of South Alabama. C215 1011.12 Selective targeting of cytochrome C–cardiolipin complex to protect mitochondrial cristae and inhibit apoptosis. A.V. Birk, S. Liu, Y. Soong, J.D. Warren and H.H. Szeto. Weill Cornell Med. Col. Visit the Exhibits C216 1011.13 Modulation of Bcl-2 proteins in an in vitro model of sepsis. J.A. Crum and V. Del Gaizo Moore. Elon Univ., NC.
336 TUESDAY BIOCHEMISTRY
C217 1011.14 Thiol-based antioxidants trigger transient 1014. CHEMISTRY AND CELL BIOLOGY OF NATURAL mitochondrial oxidation. J.N. Beaudoin, V.L. Kolossov, W. PRODUCTS Hanafin, S. DiLiberto, Jr., P.G. Kenis and H.R. Gaskins. Univ. of Illinois at Urbana-Champaign. Poster C218 1011.15 Effect of avocado oil on fatty acid profile and ROS generation in liver and aortic mitochondria from diabetic Tue. 7:30 am—Boston Convention & Exhibition Center, rats. O. Ortiz-Avila, C. Samano-Garcia, E. Calderon-Cortes, Exhibit Halls A-B A. Saavedra-Molina and C. Cortes-Rojo. Univ. Michoacana Presentation time: 1:05 pm-2:35 pm de San Nicolas de Hidalgo, Mexico. C226 1014.1 Tissue culture of the Egyptian cotton cultivars: 1012. NUCLEAR RECEPTORS IN METABOLIC production and morphological heterogeneity of primary callus tissues. H.M. Younis, M.E-T.I. Badawy and H.M.S. Darrag. SYNDROMES Alexandria Univ., Egypt. C227 1014.2 Inhibitory effects of Alaria fistulosa uronan on Poster tyrosinase activity and melanin synthesis. Y.H. Lee, B.H. Yoon Tue. 7:30 am—Boston Convention & Exhibition Center, and M.J. Ku. Kosin Med. Col. and Tongmyong Univ., South Exhibit Halls A-B Korea. C228 1014.3 Synthesis of novel Pb, Mn, Zn, Ag, Co and Presentation time: 1:05 pm-2:35 pm Cu complexes with coumarine derivative moiety and their C219 1012.1 Association of genetic polymorphism of antibacterial activities. S.R. Govori, A. Haziri, F. Palucaj, A. peroxisome proliferator-activated receptor-gamma gene and Krasniqi, A. Rifati and H. Ibrahimi. Fac. of Nat. Sci. and Univ. polycystic ovary syndrome. N.S.E. Hemimi, I.A. Shaafie and of Prishtina, Kosovo. H.H.A. Alshawa. Dubai Med. Col. and Gulf Med. Col., United C229 1014.4 Evaluation of acute toxicity (in mice) and Arab Emirates. subchronic toxicity (in rats) of aqueous extract of Tapinanthus C220 1012.2 Inhibition of secretory phospholipase A2 group bangwensis leaves grown on orange trees. S.C. Nwoke, A.O. IIa by thyroid hormone. P. Sharma, S. Thakran, X. Deng, Magbagdeola,, A.O. Ebuehi, N.A. Imaga, M. Omojufehinsi, S. M.B. Elam and E.A. Park. Univ. of Tennessee Hlth. Sci. Ctr., Gbotolorun,, G.O. Ajayi, and A. Ani. Univ. of Lagos, Nigeria. Memphis. C230 1014.5 The biogeochemical chlorine cycle in forest C221 1012.3 Retinoid X receptor alpha interaction with ecosystems. A. Pirovano and A. Leri. Marymount Manhattan sugars. F.L. Soman, C. de Jesus Piva and H.A. Hostetler. Col. Boonshoft Sch. of Med., Wright State Univ. C231 1014.6 Sensitization of NCI-H460 cells to anticancer drugs with aminoglycosides. M. Cuccarese. Northeastern 1013. ASSEMBLY AND CONTROL OF DYNAMIC Univ. C232 1014.7 Structure activity relationship study of the PROTEIN COMPLEXES cleistriosides and cleistetrosides for antibacterial/anticancer activity. P. Shi. Northeastern Univ. Poster C233 1014.8 C3’/C4’-stereochemical effects of digitoxigenin Tue. 7:30 am—Boston Convention & Exhibition Center, a-L-/a-D-glycoside in cancer cytotoxicity. S. McKenna and J. Exhibit Halls A-B Hinds. Northeastern Univ. C234 1014.9 Synergistic effects of digitoxin analogues in Presentation time: 1:05 pm-2:35 pm combination with chemotherapeutic drugs. J.W. Hinds and S. C222 1013.1 Crystal structure and in vitro analysis of McKenna. Northeastern Univ. human IQGAP1 calponin homology domain: implication for its C235 1014.10 Effects of aloe vera components on the renin- interactions with Ca2+ bound calmodulin and F-actin. J. Liu, angiotensin system in human mesangial cells. L.S. Arita, L. V. Kurella, L.F. LeCour and D.K. Worthylake. LSU Sch. of Santos, R. Yokota, M.M. Tanae, D.S. Aragão, M.D. Nogueira, T Med.,New Orleans. R.S. Banchi, L.E. Matsumoto, D.Y. Arita, T.S. Cunha, M.T.R. U C223 1013.2 Characterization of a novel interaction between Lima-Landman and D.E. Casarini. Fed. Univ. of São Paulo E BLIP-II and Staphylococcus aureus PBP2a. C.J. Adamski, and Tulane Univ. D-C. Chow, N. Brown and T. Palzkill. Baylor Col. of Med. C224 1013.3 GMPCPP and paclitaxel effect on microtubule 1015. PROTEIN-SMALL MOLECULE INTERACTIONS stiffness. S. Cheng and Z. Donhauser. Vassar Col. C225 1013.4 Monitoring the structural dynamics of Poster LRRK2 using split-luciferase protein-fragment-assisted complementation. J. Nardozzi, O. Baker, S. Wong and M.J. Tue. 7:30 am—Boston Convention & Exhibition Center, LaVoie. Harvard Med. Sch. and Brigham and Women’s Hosp. Exhibit Halls A-B Presentation time: 1:05 pm-2:35 pm C236 1015.1 Understanding protein-protein interaction network: a case study with glutaminase interacting protein. M. Ovee, D. Zoetewey, M. Banerjee, R. Bhaskaran, S. Mohanty, S. Zencir and Z. Topcu. Auburn Univ. and Ege Univ., Turkey.
337 BIOCHEMISTRY TUESDAY
C237 1015.2 Specific interaction of the TCERG1 FF4-6 1017. MEMBRANE TRANSPORT tandem repeat domains with RNA polymerase II requires simultaneous phosphorylation at Ser2, Ser5 and Ser7 of the Poster CTD. J. Liu, S. Fan, C-J. Lee, A.L. Greenleaf and P. Zhou. Duke Univ. Med. Ctr. and MRC Lab. of Molec. Biol., Cambridge, Tue. 7:30 am—Boston Convention & Exhibition Center, U.K. Exhibit Halls A-B C238 1015.3 Homogeneous, sulfated oligosaccharides from Presentation time: 12:25 pm-1:55 pm glycosaminoglycans activate promatrilysin (proMMP-7) largely + by co-localization. Y.G. Fulcher, F. Zhang, R.J. Linhardt, C248 1017.1 Mechanisms of Cu transfer from soluble + R. Sanganna Gari, S.H. Prior, Y.J. Jeong, G.M. King and Cu chaperones to transmembrane transport ATPases. S.R. Van Doren. Univ. of Missouri-Columbia and Rensselaer T.N. Padilla-Benavides, C.J. McCann and J.M. Arguello. Polytech Inst. Worcester Polytech Inst. +3 C239 1015.4 Mycobacterium smegmatis Ku binds zinc. A.K. C249 1017.2 A putative Fe /phytosiderophore transporter Kushwaha and A. Grove. LSU. isolated from oats (Avena sativa). G.T. Davis and M. C240 1015.5 The relationship between function and Stocksdale. Bloomsburg Univ., PA and Earlham Col., IN. structure of the heme-scavenging protein IsdX1. A. Kenrick, K. C250 1017.3 Nucleotide binding stabilizes Na,K-ATPase Polzin and M. McEvoy. Univ. of Arizona. quaternary structure and facilitates trafficking to plasma C241 1015.6 Guanosine-5’-triphosphate regulates the membrane. C. Galva, K.R. Louis and C. Gatto. Sch. of Biol. interaction between MciZ and FtsZ. S. Ray, A. Kumar and D. Sci., Illinois State Univ. and Univ. of Illinois, Urbana. Panda. Indian Inst. of Technol. Bombay. C251 1017.4 Identification of TMEM184A in vascular C242 1015.7 Structure-based drug design of inhibitors of endothelial and smooth muscle cells. J.B. Slee and L.J. Lowe- the CD23 and immunoglobulin E interaction. M.O.Y. Pang, J. Krentz. Lehigh Univ. McDonnell and A. Beavil. King’s Col. London. C252 1017.5 Observation of TonB motion using fluorescence C243 1015.8 Design and characterization of an EHD1 anisotropy. L.D. Jordan, Y. Zhou, C.R. Smallwood, Y. Lill, K.P. inhibitor. J. Baleja, T. Corlin, A. Kamens, A. Alt-Holland and Ritchie, W.T. Yip, S.M. Newton and P.E. Klebba. Kansas State J. Kritzer. Tufts Univ. Schs. of Med. and Dent Med. and Tufts Univ., Univ. of Oklahoma and Purdue Univ. Univ. C253 1017.6 Endosomal sorting of VAMP3 is regulated C244 1015.9 The effect of conformational changes on by phosphatidylinositol 4-kinase IIa. M. Jovic, M. Kean, A-C. non-coordinated water occupancy associated with R and T Gingras, J. Brill and T. Balla. NICHD, NIH and Samuel allosteric states of carp hemoglobin. W. Salameh, E. Padilla, Lunenfeld Res. Inst. and The Hosp. for Sick Children, Toronto. P.N. Tipgunlakant, R.A. Goldbeck and D.S. Kliger. San C254 1017.7 Postnatal injection of homocysteic acid in rats Francisco State Univ. and Univ. of California, Santa Cruz. leads to the development of schizophrenia-like behaviors. G. Flores, C. Barney and L. Chase. Hope Col., MI. C255 1017.8 Real time trafficking of System x - in COS-7 1016. CELL AND ORGANELLE DYNAMICS c cells. C. Cramer and L. Chase. Hope Col., MI. C256 1017.9 Identification of putative trafficking motifs in Poster - System xc . S. Lang, A. Georges and L. Chase. Hope Col., MI. Tue. 7:30 am—Boston Convention & Exhibition Center, C257 1017.10 Cell surface expression of xCT is regulated by Exhibit Halls A-B the Akt signaling pathway. L. Chase, D. Smith and N. Schiller. Hope Col., MI. Presentation time: 12:25 pm-1:55 pm C258 1017.11 Vitamin E and nonalcoholic fatty liver disease. C245 1016.1 The role of the C-terminus and transmembrane V. Thakur, L. Ulatowski, R. Parker, R. Zhang, X. Liu and segments in facilitating atlastin-mediated endoplasmic D. Manor. Case Western Reserve Univ., Cornell Univ. and reticulum fusion. T.Y. Liu, X. Bian, S. Sun, X. Hu, R.W. Klemm, Cleveland Clin. Fndn. W.A. Prinz, T.A. Rapoport and J. Hu. Harvard Med. Sch., C259 1017.12 Global deletion of stearoyl-CoA desaturase-2 HHMI, Col. of Life Sci., Nankai Univ. and Tianjin Key Lab. of enhances glucose tolerance. L. O’Neill and J. Ntambi. Univ. of Protein Sci., Tianjin, China and NIDDK, NIH. Wisconsin-Madison. C246 1016.2 Saccharomyces cerevisiae Env7 is a novel C260 1017.13 Characterization of the role of long chain acyl- serine/threonine kinase 16-related protein kinase and CoA synthetase 6 in skeletal muscle energy metabolism. S.Y. negatively regulates organelle fusion at the lysosomal vacuole. Bu. Kyungil Univ., South Korea. E. Gharakhanian, S. Manandhar, F. Ricarte and S. Cocca. C261 1017.14 When fed a high-fat diet,GPAT4-/- mice have California State Univ., Long Beach. an increased metabolic rate and impaired growth and weight C247 1016.3 An in vitro model of T cell exit from the T cell gain. D. Cooper and R.A. Coleman. Univ. of North Carolina at zone mediated by sub-regional co-existing CCL19 and CCL21 Chapel Hill. fields in lymph nodes.S. Andalur Nandagopal and F. Lin. Univ. of Manitoba.
338 TUESDAY BIOCHEMISTRY
1018. LIPID SECOND MESSENGERS C272 1020.2 Both full-length and exon 9-deleted human cholesteryl ester transfer protein isoforms are involved in Poster cellular lipid homeostasis. L. Izem and R.E. Morton. Lerner Res. Inst., Cleveland Clin. Tue. 7:30 am—Boston Convention & Exhibition Center, C273 1020.3 Characterization of the proteome of cytoplamic Exhibit Halls A-B lipid droplets in enterocytes in response to dietary fat. T. Presentation time: 12:25 pm-1:55 pm D’Aquila, D. Sirohi, R.J. Kuhn and K.K. Buhman. Purdue Univ. C262 1018.1 cAMP-stimulated expression of DGKq requires C274 1020.4 Characterization of a perilipin 5 splice variant. steroidogenic factor-1 and sterol regulatory element binding T.C. Hubbell, D.M. DuBreuil and J.T. Tansey. Otterbein Univ., protein. K. Cai and M. Sewer. Skaggs Sch. of Pharm. and OH. Pharmaceut. Sci., UCSD. C263 1018.2 The basis of the substrate specificity of 1021. PROTEIN-LIPID INTERACTIONS the epsilon isoform of human diacylglycerol kinase is not a consequence of competing hydrolysis of ATP. R.M. Epand, Poster A. Prodeus, B. Berno and M.K. Topham. McMaster Univ., Canada and Univ. of Utah. Tue. 7:30 am—Boston Convention & Exhibition Center, C264 1018.3 Phospholipase Cb1 is linked to RNA Exhibit Halls A-B interference of specific genes through translin-associated factor X. S. Scarlata, F. Philip and Y. Guo. Stony Brook Univ. Presentation time: 12:25 pm-1:55 pm C275 1021.1 Acrolein, a component of tobacco smoke and 1019. LIPID SIGNALING age-related oxidative stress disrupts structure and function of apolipoprotein E. T.N. Tran, Y.Y. Lee, K. Uchida and V. Poster Narayanaswami. California State Univ., Long Beach, and Grad. Sch. of Agr. Sci., Nagoya Univ., Japan. Tue. 7:30 am—Boston Convention & Exhibition Center, C276 1021.2 Fatty acids and their thioester derivatives Exhibit Halls A-B as potential endogenous ligands of LXRa. G.V. Hines, A. Presentation time: 12:25 pm-1:55 pm Kaliappan, S.D. Rider, Jr. and H.A. Hostetler. Boonshoft Sch. of Med., Wright State Univ. C265 1019.1 Characterization of tocopherol kinase activity C277 1021.3 A characterization of the modular nature in primary human coronary artery smooth muscle cells. J-M. of histone-derived antimicrobial peptides. M.E. Bustillo, Zingg, M. Meydani and A. Azzi. Tufts Univ. M.A. LaBouyer, A.L. Fischer, D.C. Webb and D.E. Elmore. C266 1019.2 Expression and characterization of Wellesley Col. recombinant neutral sphingomyelinase 2 in Escherichia coli: C278 1021.4 A modular approach to the histone H2A family evidence of sensitivity to redox state. P.P. Dotson II and M. of antimicrobial peptides. A.L. Fischer, M. Bustillo and D.E. Nikolova-Karakashian. Univ. of Kentucky. Elmore. Wellesley Col. C267 1019.3 Searching the extracellular domain of CD36 for C279 1021.5 Engineering a specific phosphatidylcholine fatty acid binding by surface plasmon resonance. A. Jay, A. binding site motif into a phosphatidylinositol-specific Chen and J.A. Hamilton. Boston Univ. phospholipase C. R. Goldstein, J. Cheng, B. Stec, A. C268 1019.4 The role of endosomal phosphoinositides in Gershenson and M.F. Roberts. Boston Col., Sanford- phagocytosis, phagosome maturation and the endosomal Burnham Med. Res. Inst., La Jolla and Univ. of Massachusetts system in macrophages. G.H.E. Kim, M. Dayam and R. Amherst. Botelho. Ryerson Univ., Canada. C280 1021.6 Role of arginine and lysine in the antimicrobial C269 1019.5 Vac14 multimerization is required for Fab1 mechanism of histone-derived peptides. K. Cutrona and D. complex assembly and function. S.C.Y. Ho, T. Alghamdi and Elmore. Wellesley Col. T R.J. Botelho. Ryerson Univ., Canada. C281 1021.7 Biochemical analysis unveils the mechanism U C270 1019.6 Membrane ultrastructure modulates immune of the interaction between Hsp70s and lipids. C. McCallister E cell signaling. A. Pralle, H. Huang and M. Simsek. Univ. at and N. Nikolaidis. California State Univ., Fullerton. Buffalo. C282 1021.8 Spatial and temporal regulation of the Nedd4 family ubiquitin ligases through phospholipid binding. J. Scott 1020. LIPID STORAGE and R.V. Stahelin. Univ. of Notre Dame and Indiana Univ. Sch. of Med. South Bend. Poster C283 1021.9 Lipid binding properties of Ebola virus matrix protein VP40. S. Yong, J.L. Scott and R.V. Stahelin. Univ. of Tue. 7:30 am—Boston Convention & Exhibition Center, Notre Dame and Indiana Univ. Sch. of Med. South Bend. Exhibit Halls A-B C284 1021.10 The interaction of Hsp70s and lipids is Presentation time: 12:25 pm-1:55 pm conserved from bacteria to humans. M.C. Siracusa and N. Nikolaidis. California State Univ., Fullerton. C271 1020.1 Cholesteryl ester transfer protein deficiency in C285 1021.11 Expression and purification of a MORN fusion adipocytes disrupts triglyceride metabolism in multiple ways. protein from Pseudomonas aeruginosa. C.C. Anderson, L.C. D.J. Greene and R.E. Morton. Lerner Res. Inst., Cleveland MacDonald, J.B. Nice, B.W. Berger and C.N. Streu. St. Clin. Mary’s Col. of Maryland and Lehigh Univ.
339 BIOCHEMISTRY TUESDAY
1022. STRESS AND LIPID METABOLISM C293 1025.2 Structural insights into the role of BamA in the biogenesis of beta-barrel membrane proteins in Gram-negative Poster bacteria. N. Noinaj, A. Kuszak, J.C. Gumbart, P. Lukacik, H. Chang, N. Easley, T. Lithgow and S.K. Buchanan. NIDDK, Tue. 7:30 am—Boston Convention & Exhibition Center, NIH, Georgia Tech, Diamond Light Source Ltd, Oxford, FDA, Exhibit Halls A-B Rockville and Monarch Univ., Australia. Presentation time: 12:25 pm-1:55 pm 1026. PROTEIN-LIPID INTERACTIONS AS C286 1022.1 Modulating lipid fate controls lipotoxicity in palmitate-treated hepatic cells. A. Leamy, M. Shiota and J. DETERMINANTS OF FUNCTION Young. Vanderbilt Univ. C287 1022.2 Protective effects of coenzyme Q10 on Poster dystrophic muscle cells. E. Minatel, D.S. Mizobuti, A.B. Tue. 7:30 am—Boston Convention & Exhibition Center, Macedo and L.H.R. Moraes. Univ. of Campinas, Brazil. Exhibit Halls A-B
Presentation time: 12:25 pm-1:55 pm 1023. STRUCTURAL BIOLOGY AND MECHANISMS OF MEMBRANE LIPID ASSEMBLY C294 1026.1 Regulation of the ATP hydrolysis and transport cycles of the P-glycoprotein multidrug transporter by sterols Poster and phospholipids. F.J. Sharom, A.T. Clay and P. Lu. Univ. of Guelph, Canada. Tue. 7:30 am—Boston Convention & Exhibition Center, C295 1026.2 Surprising phospholipid specificity of two blood Exhibit Halls A-B clotting proteins: factor VII and protein C. N. Tavoosi and J.H. Presentation time: 12:25 pm-1:55 pm Morrissey. Univ. of Illinois at Urbana-Champaign. C296 1026.3 The role of cardiolipin in defining the mammalian C288 1023.1 Probing the structure and function of ApoA-I ANT interactome. Y-W. Lu, M.G. Baile, T-C. Huang, A. Pandey C-terminal domain during HDL formation. X. Mei and D. and S.M. Claypool. Johns Hopkins Univ. Sch. of Med. Atkinson. Boston Univ. Sch. of Med. C289 1023.2 Mechanisms of non-random sphingolipid 1027. CELL CYCLE organization in the plasma membranes of fibroblast cells.M.L. Kraft, H.A. Klitzing, J.F. Frisz, K. Kou, P.K. Weber and J. Poster Zimmerberg. Sch. of Chem. Sci., Univ. of Illinois at Urbana- Champaign, Lawrence Livermore Natl. Lab. and NICHD, NIH. Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B 1024. LIPID DOMAINS AND LIPID RAFTS Presentation time: 12:25 pm-1:55 pm Poster C297 1027.1 Cell cycle regulation mechanism in pathogenic yeast, Cryptococcus neoformans: structure-function Tue. 7:30 am—Boston Convention & Exhibition Center, relationship of G1 and G1/S cyclins homologue CnCln1. S. Exhibit Halls A-B Kawamoto, E.V. Virtudazo, A. Suganami and Y. Tamura. Presentation time: 12:25 pm-1:55 pm Chiba Univ. Med. Mycol. Res. Ctr. and Grad. Sch. of Med., Japan. C290 1024.1 The iron transport inhibitor ferristatin II induces C298 1027.2 Video time lapse imaging of mitotic catastrophe degradation of transferrin receptor-1. S.L. Byrne, P.D. Buckett, events in response to thiopurines. S. Patel and D. Pittman. J. Sanford, J. Chen, C. Enns and M. Wessling-Resnick. Univ. of South Carolina and South Carolina Col. of Pharm. Harvard Sch. of Publ. Hlth. and Oregon Hlth. & Sci. Univ. C299 1027.3 Identification and characterization of mitotic C291 1024.2 Differential oligomeric nature of mEos2 and defect-related proteins (MDr1 and MDr2) necessary for bipolar mEos3.2 fluorescent proteins is consequential to diffusion and spindle assembly. K. Cheung and J. Torres. UCLA. confinement of membrane probes. E. Edwald and S.L. Veatch. C300 1027.4 The disruption of the mitotic cell cycle exit by Univ. of Michigan. inositolless death in S. cerevisiae. B.A. Hanson, P.O. O’Connor, J. Frandina, J. Pittari, J. Munezero and V. Croglio. Canisius 1025. MEMBRANE PROTEIN SYNTHESIS, INSERTION Col., NY. AND ASSEMBLY C301 1027.5 Paradoxical effects of metformin on the cell cycle in L6 myoblasts. R. Parakhia and R.S. Ochs. St. John’s Poster Univ., NY. C302 1027.6 Adiponectin receptor (ADIPOR1) signaling Tue. 7:30 am—Boston Convention & Exhibition Center, ameliorates obesity-dependent cell cycle entry in MCF7 cells. Exhibit Halls A-B M. Connor and C. Theriau. York Univ., Canada. Presentation time: 12:25 pm-1:55 pm C303 1027.7 The ubiquitin conjugating enzyme UbcH10 competes with UbcH3 for binding to the SCF complex, a C292 1025.1 Targeting of a mating machinery ATPase to ubiquitin ligase involved in cell cycle progression. A.Y. Le the cell membrane. M.P. Broulidakis, S.J. Laurer and M.B. Feuvre, D. Afful, F. Shang and A. Taylor. USDA at Tufts Univ. Berkmen. Suffolk Univ., MA.
340 TUESDAY BIOCHEMISTRY
C304 1027.8 The SUMO ligase PIAS1 promotes the 1030. CYCLINS AND CYCLIN-DEPENDENT KINASES progression and survival of solid tumors of different histopathological origins. J.D. Constanzo, A. Rabellino, G. Poster Konstantinidou, K. Schuster and P. Scaglioni. Univ. of Texas Southwestern Med. Ctr. Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B
1028. CELL CYCLE AND GROWTH CONTROL Presentation time: 12:25 pm-1:55 pm C313 1030.1 The role of cyclin-dependent kinase 5 in insulin Poster exocytosis. A. Trye and A. Aguanno. Marymount Manhattan Tue. 7:30 am—Boston Convention & Exhibition Center, Col. Exhibit Halls A-B C314 1030.2 Pentoxifylline initiates GSK-3b-induced proteasomal degradation of cyclin D1 and arrests renal cancer Presentation time: 12:25 pm-1:55 pm cells in the G1 phase. W. Cai, N.J. Mastrandrea, K.Y. Tham, C305 1028.1 MED28 regulates cell growth through HMG T.J. Monks and S.S. Lau. Univ. of Arizona Col. of Pharm. box-containing protein 1 in human breast cancer cells. N-T. C315 1030.3 Cyclin dependent kinase 5’s role in the Hsieh, C-Y. Huang, Y-H. Chou, W.C. Ung and M-F. Lee. China development of both insulin-positive and neuronal phenotypes. Med. Univ. and Chang Jung Christian Univ., Taiwan. D.E. Khost and A. Aguanno. Marymount Manhattan Col. C306 1028.2 Cranberry proanthocyanidins affect human prostate cancer cell growth via cell cycle arrest by modulating 1031. MECHANISMS OF SIGNAL TRANSDUCTION II expression of cell cycle regulators. R. Hurta, J. Kim, B. McKeown, K. Patel and C. Neto. Univ. of Prince Edward Isl., Poster Canada and Univ. of Massachusetts Dartmouth. C307 1028.3 Artemisia princeps var. orientalis induces Tue. 7:30 am—Boston Convention & Exhibition Center, cell cycle arrest accompanied by upregulation of p21,CIP1 and Exhibit Halls A-B caspase-dependent apoptosis in human breast carcinoma Presentation time: 12:25 pm-1:55 pm cells. E-J. Choi and G-H. Kim. Duksung Women’s Univ., South Korea. Session I scheduled on Monday. C308 1028.4 Functional analysis of the interaction between C316 1031.1 YAP mediates crosstalk between the Hippo Kaposi sarcoma-associated herpes virus anti-apoptotic Bcl- and PI(3)K–TOR pathways by suppressing PTEN via miR-29. 2 homolog and the human host pro-apoptotic protein, Bik. B. K.A. Tumaneng. UCSD. Caruso, S. Walker and J. Roecklein-Canfield. Simmons Col. C317 1031.2 A-kinase anchoring protein-Lbc coordinates C309 1028.5 Muscle enriched A-type lamin interacting protein kinase A phosphorylation and inhibition of Src homology protein a novel regulator cardiac growth and function. M-E. 2 domain-containing phosphatase 2. B.T. Burmeister, D.M. Cattin, E. Mak-Washburn and P.G. Burgon. Univ. of Ottawa Taglieri, L. Wang and G.K. Carnegie. Univ. of Illinois at Heart Inst. Chicago. C310 1028.6 Effects of sulforaphane on three tumor cell C318 1031.3 Specific mutations on the receptor-binding lines and one normal cell line. F. Jin, T. Terwilliger, J. Bosch interface of non-visual arrestins differently affect recruitment and R.W. O’Donnell. SUNY Geneseo. by the NPY receptor family. L.E. Gimenez, S. Babilon, A.G. C311 1028.7 Using carboxyfluorescein succinimidyl ester Beck-Sickinger and V.V. Gurevich. Vanderbilt Univ. Med. Ctr. to measure the effects of sulforaphane on cell division in a and Leipzig Univ. human leukemia cell line. K. Lehner, O. Feliciano and R.W. C319 1031.4 Analysis of MILLIPLEX® MAP NFkB signaling O’Donnell. SUNY Geneseo. using Luminex® xMAP® technology. J. Hwang, T. Warmke and R. Wiese. EMD Millipore, St. Charles, MO. T 1029. CHECKPOINT MECHANISMS C320 1031.5 Inhibition of ERK5 protects pulmonary fibrosis via downregulation of TGF-b1-Smad signaling. S. Kim, S. Park, U Poster J-H. Lim and C-H. Woo. Yeungnam Univ. and Ewha Womens E Univ., South Korea. Tue. 7:30 am—Boston Convention & Exhibition Center, C321 1031.6 PAR-1 is a novel mechano-sensor transducing Exhibit Halls A-B laminar flow-mediated endothelial signaling.S. Kim, D. Nam, J. Presentation time: 12:25 pm-1:55 pm Han and C-H. Woo. Yeungnam Univ., South Korea. C322 1031.7 Regulator of G protein signaling 6 mediates C312 1029.1 Nuclear localized BMP2 promotes cell cycle doxorubicin-induced myocardial cell apoptosis and progression. B.A. Nichols, W.A. Goar, B.T. McCune and L.C. cardiomyopathy. J. Yang, B. Maity, J. Huang, Z. Gao, A. Bridgewater. Brigham Young Univ. Stewart, R.M. Weiss, M.E. Anderson and R.A. Fisher. Univ. of Iowa. C323 1031.8 RGS6 deficiency promotes anxiolytic and
antidepressant behavior through potentiation of 5-HT1AR signaling. A. Stewart, B. Maity, A.M. Wunsch, J.A. Wemmie and R.A. Fisher. Univ. of Iowa.
341 BIOCHEMISTRY TUESDAY
C324 1031.9 The conformation of active receptor-bound C339 1031.24 Identification of key signaling molecules arrestin. V. Gurevich, M. Kim, S.A. Vishnivetskiy, N. Van Eps, downstream of cAMP that regulate insulin secretion. J.C. N.S. Alexander, W.M. Cleghorn, X. Zhan, S.M. Hanson, T. Neuman, N.A. Truchan, R.L. Pasker and M.E. Kimple. Univ. Morizumi, O.P. Ernst, J. Meiler and W.L. Hubbell. Vanderbilt of Wisconsin-Madison. Univ., UCLA and Univ. of Toronto. C340 1031.25 Novel signaling pathways triggered by a C325 1031.10 Protein structure in context: the landscape of human alpha1a-adrenoceptor genetic variant. A. Oganesian, angiogenesis. E.A. Pellmann, D. Goodsell, R. Ramchandran, M. Kleine-Brueggeney, I. Gradinaru, E. Babaeva and D.A. M. Franzen, T. Herman and D. Sem. Concordia Univ. Schwinn. Univ. of Washington and Univ. of Iowa. Wisconsin, The Scripps Res. Inst., Med. Col. of Wisconsin and Milwaukee Sch. of Engin. 1032. APOPTOSIS AND CELL STRESS C326 1031.11 A BRAF-MEK complex reveals the molecular basis of oncogenic mutations. S.G. Hymowitz, J. Sudhamsu, Poster J. Haling, A. Peck, I. Yen, T. Morales, B. Brandhuber and S. Malek. Genentech, South San Francisco and Array BioPharma, Tue. 7:30 am—Boston Convention & Exhibition Center, Boulder. Exhibit Halls A-B
C327 1031.12 Role of PLD and PA in alcohol (EtOH)-mediated Presentation time: 12:25 pm-1:55 pm mTOR signaling in C2C12 myocytes. L.Q. Hong-Brown, C.R. Brown, M. Navaratnarajah and C.H. Lang. Penn State Col. of C341 1032.1 The Bcl-2 family members Mcl-1 and Bim Med. modulate apoptosis in glutamine-deprived Sp2/0-Ag14 mouse C328 1031.13 Control of entry into meiosis and quiescence in cells. E.R. Gauthier, C. Zhou, J. Woodley and C. Harnett. budding yeast. S. Sarkar, J. Millar and P. Arumugam. Univ. of Laurentian Univ., Canada. Warwick, U.K. C329 1031.14 Estrogen regulation of Jun and Fos in MCF- 1033. BIOCHEMICAL PHARMACOLOGY 7 cells. R. Geck, J.N. Magill and J.M. Schmitt. George Fox Univ., OR. Poster C330 1031.15 AKAP7 regulates CaM kinase activation in Tue. 7:30 am—Boston Convention & Exhibition Center, MCF-7 cells. H.M. McFarland, K. Dodge-Kafka and J.M. Exhibit Halls A-B Schmitt. George Fox Univ., OR and Univ. of Connecticut Hlth. Ctr. Presentation time: 12:25 pm-1:55 pm C331 1031.16 Arrestin-dependent activation of ERK1/2 in response to follicle stimulating hormone. S. Chevalier and B. C342 1033.1 An oxygen-chelate precious metal-based Cohen. Union Col., NY. complex, palladium bis-acetylacetonate, induces apoptosis C332 1031.17 miR-27b regulates expression of fibrotic genes in lung cancer H460 cells via endoplasmic reticulum stress by targeting Gremlin 1. J.R. Graham, C. Williams and Z. Yang. pathway rather than interacting with DNA. Y. Wang, X. Li, H. Pfizer Inc., Cambridge, MA. Zhou and G. Liang. Sch. of Pharm., Wenzhou Med. Col., C333 1031.18 Identification of regulatory factors of the China and Virginia Commonwealth Univ. stationary phase sigma factor RpoS in Escherichia coli. K. C343 1033.2 Apigenin and kaempferol inhibit LPS-induced Nguyen and C. Peterson. Suffolk Univ., MA. inflammatory responses by regulating intracellular translocation C334 1031.19 Analysis of novel interacting protein partners of RNA-binding protein HuR in macrophages. X. Zhang, G. of Wwsc1p and Mid2p, two sensor proteins of the PKC1 Wang, R. Liu, L. Zhang, P.B. Hylemon, W.M. Pandak and H. signaling pathway. E. Santiago, C. De Jesús, A. Borrero, N.M. Zhou. Virginia Commonwealth Univ., China Pharmaceut. Univ., Caballero, O.J. Diaz, I. Stagljar and J.R. Rodríguez-Medina. Nanjing and McGuire VA Med. Ctr. Univ. of Puerto Rico Med. Sci. Campus and Río Piedras C344 1033.3 Wagonin inhibits LPS-induced expression of Campus, San Juan Bautista Sch. of Med., PR, Ederly Col. of inflammatory cytokines by promoting mRNA degradation in Sci., Penn State, Univ. of Puerto Rico Mayaguez Campus and macrophages. X. Wan, Y. Huang, G. Liang, J. Xiao, X. Li, E.C. Univ. of Toronto. Gurley and H. Zhou. Sch. of Pharm., Wenzhou Med. Col., C335 1031.20 Determinants of physical and functional China and Virginia Commonwealth Univ. coupling between thromboxane A2 receptor and Gaq. R. C345 1033.4 Spice synthetic cannabinoid drugs: lung and Chakraborty, B. Xu, R.P. Bhullar and P. Chelikani. Univ. of adrenal cell models. O.A. Vanderpuye, T. Smith, B. Walker, M. Manitoba. Gilbert and O. Okediji. Albany State Univ. C336 1031.21 Tumor suppressor p53 status as a determinant C346 1033.5 Production of transgenic mice expressing of estrogen receptor beta signaling in breast cancer. G.M. Das, human protein C. K-S. Min, T. Nanjidsuren, C-W. Park and U.K. Mukhopadhyay, S. Bansal, R. Medisetty, W.M. Swetzig S-J. Yun. Hankyong Natl. Univ., South Korea. and N. Wickramasekera. Roswell Park Cancer Inst. C347 1033.6 Expression of 20[alpha] HSD in porcine ovary C337 1031.22 Multiple solvent crystal structures of Rap1a and placenta during early pregnancy. K-S. Min, T. Nanjidsuren GTPase. P. Donohue and C. Mattos. Northeastern Univ. and C-W. Park. Hankyong Natl. Univ., South Korea. C338 1031.23 V-ATPase is a novel evolutionarily conserved C348 1033.7 Mutation of non-essential cysteines leads to cytohesin-signaling receptor. H. Hosokawa, P.V. Dip, M. highly soluble and active recombinant full-length NEMO. S.M. Merkulova, A. Bakulina, Z. Zhuang, A. Khatri, X. Jian, P.A. Cote, M. Herscovitch, R. Prenovitz, T. Ennis, T.D. Gilmore Randazzo, D.A. Ausiello, G. Grüber and V. Marshansky. and A. Whitty. Boston Univ. Massachusetts Gen. Hos., Harvard Med. Sch., Nanyang Tech. Univ., Singapore, State Res. Ctr. Virol. Biotech., Koltsovo, Russia and NCI, NIH.
342 TUESDAY BIOCHEMISTRY
C349 1033.8 Characterization of simvastatin-induced 1036. SIGNALING TO THE CYTOSKELETON structural and functional alterations in the molecules of kidney brush border membrane by ATR-FTIR spectroscopy and Poster chemometric approaches. F. Severcan, S. Uzun Gocmen, N. Simsek Ozek and M. Severcan. Middle East Tech Univ. and Tue. 7:30 am—Boston Convention & Exhibition Center, Mustafa Kemal Univ. Fac. of Med., Turkey. Exhibit Halls A-B C350 1033.9 Fertility activity of aqueous leaf extract of Presentation time: 12:25 pm-1:55 pm Tapinanthus bangwensis on ovulation in female Sprague- Dawley rats. D. Onadeko, S.C. Nwoke, A.O. Magbagdeola,, C358 1036.1 AKAP79 interacts with the axon guidance A.O. Ebuehi, N.O. Imaga, G.O. Ajayi, and S.C. Gbotolorun,. receptor Robo2. B. Samelson, M. Colledge and J. Scott. Univ. of Lagos, Nigeria. Univ. of Washington. C359 1036.2 Two domains of the smoothelin-like 1 protein bind apo- and calcium-calmodulin independently. A. Ulke- 1034. CASPASES Lemee, H. Ishida, H.J. Vogel and J.A. MacDonald. Univ. of Calgary, Canada. Poster C360 1036.3 Investigating the role of neuronal AKAP220 Tue. 7:30 am—Boston Convention & Exhibition Center, signaling complexes in cytoskeletal regulation during neurite Exhibit Halls A-B outgrowth. J.L. Whiting, B. Tunquist and J.D. Scott. Univ. of Washington and Array BioPharma, Boulder. Presentation time: 12:25 pm-1:55 pm C361 1036.4 A functional analysis of the projection C351 1034.1 Expression of a metacaspase from the fungus domain of the microtubule associated protein tau using force Schizophyllum commune. E.B. Loew and K.M. Fox. Union spectroscopy. J. Saunders and Z. Donhauser. Vassar Col. Col., NY. C362 1036.5 Identification of calregulin binding proteins in C352 1034.2 Expression, extraction and activity testing of a renal cell line. A.A. Alli, M.S. Ghant, D.S. Montgomery and the metacaspase Scp3. C. Gagliardi and K.M. Fox. Union D.C. Eaton. Emory Univ. and Clark Atlanta Univ. Col., NY. C363 1036.6 Anillin regulates cell-cell junction integrity in the intact epithelium via RhoA and F-actin. A.L. Miller, C.C. 1035. CELL PROLIFERATION Reyes, M. Jin, R. Espino, E. Breznau and A. Goryachev. Univ. of Michigan and Sch. of Biol. Sci., Univ. of Edinburgh. Poster 1037. TOXINS Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Poster pm pm Presentation time: 12:25 -1:55 Tue. 7:30 am—Boston Convention & Exhibition Center, C353 1035.1 Identification and expression analysis of two Exhibit Halls A-B
homologs from Xenopus laevis of the tumorhead putative Presentation time: 12:25 pm-1:55 pm binding protein, FBXO30. J.M. Ayala-Figueroa, N. Flores, D. Nuñez, T. Zbinden and E. Traverso. Univ. of Puerto Rico at C364 1037.1 Mechanism of non point source(s) causing Humacao and Rio Piedras. antibiotic-resistance in infectious diseases. S. Kannan, J. C354 1035.2 Functional characterization of novel tumor Martinez, H. Montoya, J. Barrera, R. Cooley, M. Orozco and suppressor protein Sav1 in cancer cell proliferation and B. Villanueva. Southwest Texas Junior Col., Fort Duncan Reg. epithelial-mesenchymal transition. N. Sakai and K. Shibata. Med. Ctr., Waste Water Recycling Plant, City of Eagle Pass Himeji Dokkyo Univ., Japan. Water Works, CEPWW, Maverick County Water Control and C355 1035.3 Identification of binding proteins of the Xenopus Improvement District #1, Eagle Pass, TX. T morphogenetic factor, Tumorhead. K.M. Alicea-Torres, E. C365 1037.2 Detection of aniline resistant and streptomycin U Lopez, N. Flores, I.E. Vega and E.E. Traverso. Univ. of Puerto sensitive yeast R11 in processed biosolid. S. Kannan, E Rico at Humacao and Univ. of Puerto Rico at Rio Piedras. H. Montoya, J. Barrera, E. Longoria and A. Castillion. C356 1035.4 CTP synthase, a smooth muscle-sensitive Southwest Texas Junior Col., City of Eagle Pass Waste Water therapeutic target for effective vascular repair after injury. R. Processing Plant and Eagle Pass Reg. Water Treatment Plant. Tang. Univ. of Georgia. C357 1035.5 Retardation of cell proliferation by low- 1038. PROTEIN PHOSPHORYLATION AND temperature atmospheric plasma exposure on C2C12 DEPHOSPHORYLATION myoblast. N. Nakai, F. Kawano and Y. Ohira. Osaka Univ. Poster
Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B
Presentation time: 12:25 pm-1:05 pm C366 1038.1 Hepatocyte nuclear factor-4 phosphorylation mediated by inflammatory response.Z. Wang, E. Salih and P.A. Burke. Boston Univ. Sch. of Med. and Henry M. Goldman Sch. of Dent. Med.
343 BIOCHEMISTRY TUESDAY
C367 1038.2 Discovery of a bis-phosphokinetic motif in a 1040. G PROTEINS AND PROTEIN KINASES regulatory region of the transcription factor, BCL11B. T.M. Filtz, W.K. Vogel, P.R. Gafken and M. Leid. Oregon State Univ. and Poster Fred Hutchinson Cancer Res. Ctr. C368 1038.3 Phosphorylation-dependent interaction of Tue. 7:30 am—Boston Convention & Exhibition Center, PRIP with Akt. G. Sugiyama, K. Nagano, T. Otani, J. Gao, H. Exhibit Halls A-B Takeuchi and M. Hirata. Fac. of Dent. Sci., Kyushu Univ. and Presentation time: 12:25 pm-1:55 pm Kyushu Dent. Col., Japan. C369 1038.4 Pasteurella multocida toxin activates mTOR C379 1040.1 Role of the GRK2 extreme amino terminus and and inhibits PP2A via Gaq/11/PLCb/PKC. H. Oubrahim, Y. Shi active site tether in forming G protein-coupled receptor docking and P.B. Chock. NHLBI, NIH. site. R. Sterne-Marr, K. Michalski, A. Beautrait, T. Lopez, K. C370 1038.5 Two unique phosphorylation-driven signaling Mannix, D. McDonald, A. Cutter, C. Francis, C. Medina, M. pathways crosstalk in Staphylococcus aureus: STK1 meets Bouvier and J. Tesmer. Siena Col., NY, Univ. of Montreal and GraR. M. Fridman and D. Golemi-Kotra. York Univ., Canada. Univ. of Michigan. C371 1038.6 Analysis of neuronal migration defects in src-1 C380 1040.2 S1P1 receptor regulation by phosphorylation. mutant and Fyn transgenic C. elegans. K.L. Hinkle, Z. Fulton, S. Bazúa-Valenti, M.A. Morquecho-León, M.T. Romero- E. Chapdelaine and B. Ballif. Norwich Univ., VT and Univ. of Ávila and J.A. García-Sáinz. UNAM, Mexico City. Vermont. C381 1040.3 Lysophosphatidic acid-stimulated p130Cas C372 1038.7 Protein tyrosine phosphatase 1B antagonized phosphorylation and invasive migration of ovarian cancer cells Brk-mediated IGF-1R signaling in ovarian cancer. G. Fan, C. involves a Gai2-dependent signaling mechanism. J. Ward and Fu, G. Lin, D. Pappin, R. Lucito and N.K. Tonks. Cold Spring D. Dhanasekaran. Univ. of Oklahoma Hlth. Sci. Ctr. Harbor Lab., NY. C382 1040.4 Structures of the G-beta–CCT and PhLP1–G- C373 1038.8 Phosphorylation of tau-4R and microtubule beta–CCT complexes reveal a molecular mechanism for G binding region of MAP-2C by PKA and GSK-3b inhibits their protein beta subunit folding and beta-gamma dimer assembly. O-glycosylation by OGT. B.S. Khatra, M. Juarez, D. Johnson R. Plimpton, J. Cuellar, C.W.J. Lai, R. Taylor, J.L. Carrascosa, and M. DeTure. California State Univ., Long Beach and Mayo J.T. Prince, J. Valpuesta and B.M. Willardson. Brigham Young Clin., Jacksonville, FL. Univ. and Natl. Biotechnol. Ctr., Madrid. C374 1038.9 Phosphorylation of the eukaryotic cortactin protein by endogenous kinases in an E. coli expression system. 1041. KINASE CASCADES J. Priester, H. Love and A. Kruchten. Linfield Col., OR. Poster
1039. ADAPTER PROTEINS Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Poster Presentation time: 12:25 pm-1:55 pm Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B C383 1041.1 Quantitative analysis of how RET receptor activation is coupled to ERK and Akt signaling. S. Li, J. Presentation time: 12:25 pm-1:55 pm Noorbakhsh, T.V. Riera, P. Mehta and A. Whitty. Boston Univ. C375 1039.1 Cypher/ZASP, a PKA scaffolding protein to C384 1041.2 Beta synemin binds PKA type I upon beta- regulate the phosphorylation of L-type calcium channel. H. adrenergic stimulation in HL-1 cells. B.C. Prudner, D.S. Cheng, C. Lin, X. Yin, X. Guo, J. Chen and Y. Ke. First Affil. Damron and M.A. Russell. Kent State Univ. and Kent State Hosp., Zhejiang Univ. Sch. of Med., China and UCSD Sch. of Univ. Trumbull. Med. C385 1041.3 Control of plasma membrane lipid asymetry at C376 1039.2 Dissecting distinctive roles of GAB scaffolding the bud neck: septin-bound protein kinase Gin4 locally controls proteins in allergic inflammation in vivo.Y. Zhang, X. Zhang, flippase function. F.M. Roelants, B. Su, J. von Wulffen and J. J. Xu, B. Tao, Z. Liang, H. Cheng and Y. Ke. Zhejiang Univ., Thorner. Univ. of California, Berkeley. China. C386 1041.4 Characterization of BI-D1870, the ATP- C377 1039.3 Identifying chemotaxis protein-protein competitive small molecule inhibitor of p90 ribosomal S6 interactions in Epulopiscium sp. type B using a yeast two hybrid kinase. L.S. Jones. Univ. of North Carolina at Chapel Hill. system. B. Levesque and A.J. Piefer. Hartwick Col., NY. C378 1039.4 Chemotaxis in Epulopiscium. P. Faughnan 1042. MAP KINASES and A. Piefer. Hartwick Col., NY. Poster
Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B
Presentation time: 12:25 pm-1:55 pm C387 1042.1 Investigating inactive conformations of protein kinases. S.B. Hari, B.G.K. Perera, S.E. Leonard and D.J. Maly. Univ. of Washington.
344 TUESDAY BIOCHEMISTRY
C388 1042.2 Epitope guided engineering of monobody 1044. RECEPTOR TYROSINE KINASE SIGNALING TO binders for in vivo inhibition of Erk-2 signaling. S. Park, J.K. NUCLEUS Mann, J.F. Wood, A.F. Stephan, E.S. Tzanakakis and D.M. Ferkey. Univ. at Buffalo, SUNY. Poster C389 1042.3 Characterization of a microtubule-associated protein, doublecortin (DCX), as a substrate of c-Jun N-terminal Tue. 7:30 am—Boston Convention & Exhibition Center, kinases. K. Ngoei, P.R. Gooley, M.W. Parker and M.A. Exhibit Halls A-B Bogoyevitch. Univ. of Melbourne and St. Vincent’s Inst. of Presentation time: 12:25 pm-1:55 pm Med. Res., Fitzroy, Australia. C390 1042.4 JNK3 binding to arrestin-3 differentially affects C400 1044.1 Meta-analysis of nuclear targets of tyrosine recruitment of upstream MAP kinase kinases. X. Zhan, T.S. phosphorylation: identifying nodes that regulate nuclear activity. Kaoud, S. Kook, K.N. Dalby and V.V. Gurevich. Vanderbilt P.V. Hornbeck, J. Kornhauser, E. Skrzypek, B. Zhang, V. Univ. and Univ. of Texas at Austin. Latham and B. Murray. Cell Signaling Technol., Danvers, MA. C391 1042.5 The effect of TBBPA on MAP3Ks in human C401 1044.2 Src kinase mediates renal interstitial fibroblast natural killer cells. L.J. Celada and M.M. Whalen. Tennessee activation and proliferation. L. Ma, J. Tang, M. Ponnusamy and State Univ. S. Zhuang. Brown Univ.-Rhode Island Hosp. C392 1042.6 Arrestin-3 binding to JNK1alpha1/JNK2alpha2: modulation of JNK1 and JNK2 activity via scaffolding. S. 1045. SERINE/THREONINE KINASE Kook, X. Zhan, T.S. Kaoud, K.N. Dalby, V.V. Gurevich and E.V. Gurevich. Vanderbilt Univ. Med. Ctr. and Univ. of Texas at Poster Austin. Tue. 7:30 am—Boston Convention & Exhibition Center, C393 1042.7 Overcoming drug-induced resistance in BRaf Exhibit Halls A-B mutated melanoma cells. R. Samadani, K-Y. Jung, J. Zhang, A. MacKerell, S. Fletcher and P. Shapiro. Univ. of Maryland Presentation time: 12:25 pm-1:55 pm Baltimore. C402 1045.1 Protein kinase C mutations in cancer. C.E. Antal, E. Kang and A.C. Newton. UCSD. 1043. PHOSPHATASES C403 1045.2 Structural insights into the VRK1-mediated histone phosphorylation and its regulation by mH2A1, a histone Poster H2A variant. H.S. Yoon, J. Shin and G. Chakraborty. Sch. of Tue. 7:30 am—Boston Convention & Exhibition Center, Biol. Sci., Nanyang Technol. Univ., Singapore. Exhibit Halls A-B C404 1045.3 Using ProPeL to discover the binding specificity of human DYRK1a. J. Lubner, M.F. Chou, G.M. Church and D. Presentation time: 12:25 pm-1:55 pm Schwartz. Univ. of Connecticut and Harvard Med. Sch. C394 1043.1 Molecular basis for a bipartite phosphatase C405 1045.4 RhoA kinase phosphorylation of NHE1 impact interaction with the anchoring protein AKAP79. P.J. Nygren, on growth factor and G protein coupled receptor signaling. N. M.G. Gold, C.R. Weisbrod, J.E. Bruce and J.D. Scott. Univ. of Berthelsen, H. Pantera, J. Sauer, J. Lawrence, M. Wallert Washington and University Col. London. and J. Provost. Minnesota State Univ. Moorhead and Univ. of C395 1043.2 Structural mechanism of trimeric PR70 PP2A Wisconsin-Stevens Point. holoenzyme: insights into Cdc6 dephosphorylation. N.J. C406 1045.5 Structure of the eukaryotic atypical RIO Wlodarchak, F. Guo, K.A. Satyshur, L. Jiang, P.D. Jeffrey, kinases reveals ATPase-dependent mechanism in ribosome T. Sun, V. Stanevich, M.C. Mumby and Y. Xing. Univ. of biogenesis. N.A. LaRonde. Univ. of Maryland College Park. Wisconsin-Madison, Princeton Univ. and Univ. of Texas C407 1045.6 Investigations into the role of lantibiotic Southwestern Med. Ctr. cyclase-like proteins in mammals. M. Zeng, J. Chen and W. C396 1043.3 Structural basis of PP2A phosphatase activator van der Donk. Univ. of Illinois at Urbana-Champaign. T reveals a unique chaperone function in PP2A activation. F. Guo, U V. Stanevich, N. Wlodarchak, Y. Li, D.C. Pallas, R. Sengupta, 1046. SMALL GTPASES E L. Jiang, K.A. Satyshur and Y. Xing. Uof Wisconsin-Madison, Sch. of Med. and Publ. Hlth. and Emory Univ. Sch. of Med. Poster C397 1043.4 Regulation of epithelial-mesenchymal Tue. 7:30 am—Boston Convention & Exhibition Center, transition and apoptosis by dual specificity phosphatase-2. Exhibit Halls A-B S-C. Lin, K-Y. Hsiao and S-J. Tsai. Natl. Cheng Kung Univ., Taiwan. Presentation time: 12:25 pm-1:55 pm C398 1043.5 Structural basis of stable PP2A latency by a4- protein. V. Stanevich, L. Jiang, R. Sengupta, K. Satyshur, C408 1046.1 Role of DLC1 in regulating cellular and focal G. Watkins, B. Wadzinski, M. Kong and Y. Xing. Univ. of adhesion dynamics. S. Kaushik and B.C. Low. Natl. Univ. of Wisconsin-Madison, Vanderbilt Univ. Med. Ctr. and City of Singapore and Mechanobiol. Inst., Singapore. Hope Natl. Med. Ctr., Duarte, CA. C409 1046.2 The identification, characterization, and C399 1043.6 Structural insights into tight control of PP2Aa subcellular localization of a novel potential GTPase activating methylation and function by LCMT-1. V. Stanevich, L. Jiang, K. protein involved in cytokinesis. S.L. Faitar, J.J. Kilijanski, K.W. Satyshur, Y. Li, P. Jeffrey, Z. Li, P. Menden, M. Semmelhack Heassler and J.J. Davie. D’Youville Col., NY. and Y. Xing. Univ. of Wisconsin-Madison and Princeton Univ.
345 BIOCHEMISTRY TUESDAY
C410 1046.3 Ras activity regulation by monoubiquitination. 1049. CYCLASES S.L. Campbell, R. Baker, S. Lewis, A. Sasaki, E.M. Wilkerson, J. Locasale, L.C. Cantley, B. Kuhlman and H. Dohlman. Univ. Poster of North Carolina at Chapel Hill and Harvard Med. Sch. C411 1046.4 PDZ-RhoGEF and LARG are essential for Tue. 7:30 am—Boston Convention & Exhibition Center, embryo development, and provide a link between thrombin Exhibit Halls A-B receptors and Rho activation. C.M. Mikelis, M. Simaan, W. Presentation time: 12:25 pm-1:55 pm Li, R. Szabo, D. Martin, Y. Mukouyama, T.H. Bugge and S.J. Gutkind. NIDCR and NHLBI, NIH. C421 1049.1 Nasal mucus contains cAMP and cGMP which C412 1046.5 Contribution of residue 188 identity to RhoA are critical factors in preservation of normal olfaction. R.I. and RhoC membrane association. N. Peyton, A. Reicks, A. Henkin. The Taste and Smell Clin., Washington, DC. Patel and S. Ellerbroek. Wartburg Col., IA. C422 1049.2 ATP inhibition couples guanylyl cyclase A and C413 1046.6 Over-expression of mutant Rheb proteins and B to cellular energy status. L.R. Potter, M.A. Mauseth and mTOR signaling. D. Teran and N. Parmar. California State J.W. Robinson. Univ. of Minnesota, Minneapolis. Univ. Channel Islands. C414 1046.7 Rac1b, a variant of Rac1 interacts with 1050. INOSITOL PHOSPHATES AND calmodulin. N. Khanna, B. Xu, P. Chelikani and R.P. Bhullar. PHOSPHOINOSITIDES Univ. of Manitoba. Poster
1047. CALCIUM Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Poster Presentation time: 12:25 pm-1:55 pm Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B C423 1050.1 Tertiary conformational transition in horse haemoglobin induced by inositol hexakisphosphate. O.E. Presentation time: 12:25 pm-1:55 pm Omotosho, K.O. Okonjo, V.T. Omotosho, S.O. Rotimi and C415 1047.1 LT1002 metalloantibody uses Ca2+ cofactor. S.N. Chinedu. Covenant Univ., Nigeria. A.D. Ward, D. Yacoub, F. Erasmus and T. Huxford. San Diego C424 1050.2 The effect of phosphatidylinositol State Univ. 4,5-bisphosphate depletion on the internalization of G protein- C416 1047.2 Automated analysis of Ca2+ mobilization in the coupled receptors. D.J. Tóth, J.T. Tóth, B. Tallósy, L. Hunyady cornea under hypoxia. A. Lee, K. Derricks and V. Trinkaus- and P. Várnai. Fac. of Med., Semmelweis Univ. and Hungarian Randall. Boston Univ. Sch. of Med. Acad. of Sci., Budapest. C417 1047.3 Calcium-induced structural changes of the C425 1050.3 The kinetic properties of a human PPIP5K CaM–KCNQ complex. A. Lvov, K. Mruk and W.R. Kobertz. reveal that its kinase activities are protected against the Univ. of Massachusetts Med. Sch. and Stanford Univ. Sch. of consequences of a deteriorating cellular bioenergetic Med. environment. J.D. Weaver, H. Wang and S.B. Shears. NIEHS, C418 1047.4 Endothelial cell-specific STIM1 deletion NIH, Research Triangle Park. prevents lung vascular leak. A. DebRoy, S.M. Vogel, P.C. Sundivakkam, Y-Y. Zhao, A.B. Malik and C. Tiruppathi. Univ. 1051. NITRIC OXIDE of Illinois at Chicago. C419 1047.5 A role for the excess ryanodine receptors in Poster excitation-contraction coupling. S. Pitake and R.S. Ochs. St. Tue. 7:30 am—Boston Convention & Exhibition Center, John’s Univ., NY. Exhibit Halls A-B
1048. GTPASES Presentation time: 12:25 pm-1:55 pm C426 1051.1 Endomembrane HRas controls the PI3 kinase/ Poster Akt/eNOSsignaling cascade in VEGF induced endothelial Tue. 7:30 am—Boston Convention & Exhibition Center, cell migration. D. Haeussler, J.R. Burgoyne, X. Hou, D.R. Exhibit Halls A-B Pimental, R.A. Cohen and M.M. Bachschmid. Boston Univ. Sch. of Med. and King’s Col. London. Presentation time: 12:25 pm-1:55 pm C427 1051.2 A muscle-specific isoform of neuronal nitric C420 1048.1 Human and murine Evc proteins contain oxide synthase is phosphorylated in response to insulin. K. functional P-loops and possess intrinsic GTPase activity. O.O. Hinchee-Rodriguez, N. Garg, P. Venkatakrishnan, M.G. Odunuga. Stephen F. Austin State Univ., TX. Roman, M. Adamo, B.S. Masters and L.J. Roman. Univ. of Texas Hlth. Sci. Ctr. at San Antonio. C428 1051.3 Protein phosphatase 2A B56a mediates retinoic acid-induced decreases in phosphorylation of endothelial nitric oxide synthase at serine 1179 and nitric oxide production. I. Jo, J-H. Park, H.Y. Sung, J.Y. Lee, H.J. Kim and J-H. Ahn. Ewha Womans Univ. Med. Sch., South Korea.
346 TUESDAY BIOCHEMISTRY/NUTRITION
1052. PHOSPHODIESTERASES C431 1052.3 Selective regulation of PDE3A isoforms by differential phosphorylation. F. Vandeput, N. Szabo-Fresnais, Poster A. Dunlop, J. Krall, V.C. Manganiello, M.D. Houslay and M.A. Movsesian. VA Salt Lake City Hlth. Care Syst., Univ. of Utah, Tue. 7:30 am—Boston Convention & Exhibition Center, Univ. of Glasgow, U.K., NHLBI, NIH and King’s Col. London. Exhibit Halls A-B C432 1052.4 Proteomic identification of preferential Presentation time: 12:25 pm-1:55 pm interactions between PDE6 and its inhibitory subunit. K.A. Kozacka, X-J. Zhang, X-Z. Gao, X. Zeng, F. Chu and R.H. C429 1052.1 Heterologous expression of human Cote. Univ. of New Hampshire. phosphodiesterase 3A enhances oxidative stress resistance in C433 1052.5 Probing the structure of photoreceptor yeast. D.K. Rhee, J.C. Lim, S.C. Hockman, F. Ahmad and V.C. phosphodiesterase (PDE6) and its interactions with transducin Manganiello. NHLBI, NIH. by cross-linking and molecular modeling. X-Z. Gao, X. Zeng, C430 1052.2 Regulation of photoreceptor phosphodiesterase X-J. Zhang, F. Chu and R.H. Cote. Univ. of New Hampshire. (PDE6) by the rod photoreceptor-specific glutamic acid-rich C434 1052.6 PDE inhibitors as potential pesticides targeting protein 2. W. Yao and R.H. Cote. Univ. of New Hampshire. parasitic nematodes. K.D. Schuster, K.B. Cahill, K. Morris, W.K. Thomas and R.H. Cote. Univ. of New Hampshire.
Nutrition
1053. NUTRITION, PHYSICAL PERFORMANCE AND D8 II 1053.8 Effect of saturated or monounsaturated BONE HEALTH fatty acids on bone and calcium absorption in older mice. Y. Wang, P. Dellatore, K. Patel, R. Ferraris and S. Shapses. Poster Rutgers Univ. and UMDNJ-New Jersey Med. Sch. D9 I 1053.9 The efficacy of tart cherry (Sponsored by: Aging and Chronic Disease RIS) supplementation in the prevention of age-related bone loss in Tue. 7:30 am—Boston Convention & Exhibition Center, C57BL6 mice. P. Chongwatpol, E. Rendina, J.L. Graef, S.L. Exhibit Halls A-B Clarke, E.A. Lucas and B.J. Smith. Oklahoma State Univ. D10 II 1053.10 Novel anti-osteoclastogenic activity of Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) fisetin antagonizing RANKL-induced bone resorption in murine D1 I 1053.1 Effects of short-term protein macrophages. Y. Kim, J-L. Kim and Y-H. Kang. Hallym Univ., supplementation on muscle work efficiency in elderly adults. South Korea. K.A. Sands, K.L. Clark, S.P. McKenzie, J.M. Haddad, S. D11 I 1053.11 Osteogenic activity of milk thistle extract Rietdyk and W.W. Campbell. Purdue Univ. and Indiana Univ.- after ovariecotmy to dampen estrogen deficiency-induced Purdue Univ. Indianapolis. osteoporosis. J-L. Kim, Y. Kim, E. Lee and Y-H. Kang. Hallym D2 II 1053.2 Dairy foods intake and bone health. Univ., South Korea. N.A.G. de França, B.S.E. Peters, W.N. de Souza, M.R. D12 II 1053.12 Dietary intake of purple sweet potato Camargo, M. Lazaretti-Castro and L.A. Martini. São Paulo powder affected bone mineral content of ovariectomized rats. Univ., Brazil and Fed. Univ. of São Paulo. C. Wang, L. Huang, X. Zheng and C. Butler. Kentucky State D3 I 1053.3 Genistein activates BMP-Smad Univ. and Northwest A&F Univ., China. signaling pathway in MC3T3-E1 cells. H. Katsuyama, S. D13 I 1053.13 High blood pressure and arterial stiffness are not associated with low bone mass. S.A. Johnson, Fushimi, K. Yamane, H. Hinenoya, Y. Akiyama, M. Tomita, T T. Okuyama, Y. Watanabe, M. Katsuyama and K. Saijoh. A. Figueroa, N. Navaei, A. Wong, R. Kalfon, M. Elam, M. Kawasaki Med. Sch. and Kanazawa Univ. Sch. of Med., Japan. Payton and B.H. Arjmandi. Florida State Univ. and Oklahoma U D4 II 1053.4 Cortical femur response to synbiotics State Univ. E in aging mice. C. Blanton, M. Tyler and A. Gabaldon. Idaho D14 II 1053.14 Association between serum levels of State Univ. and Colorado State Univ.-Pueblo. vitamin D with body fat mass, fasting glucose and lipid profile D5 I 1053.5 Estrogen deficiency worsened Ca in patients with osteogenesis imperfecta. B.S.E. Peters, M. balance via downregulation of epithelial Ca transport proteins Lazaretti-Castro, L.F. Hayashi, A.V. Costa and L.A. Martini. in aged female rats. M.S. Wong, X. Dong and Y. Zhang. The São Paulo Fed. Univ. and Univ. of São Paulo. Hong Kong Polytech Univ. D15 I 1053.15 The relationship between sex hormones D6 II 1053.6 New formulation with potential for the and osteoarthritis. R.G. Feresin, M.L. Elam, Y. Zhao, S. prevention and treatment of osteoporosis and osteoarthritis. Hooshmand and B.H. Arjmandi. Florida State Univ. and San A. Torrent, E. Montell, J. Vergés, R. Ruhí, P. Dalmau, M.C. Diego State Univ. Sch. of Exer. and Nutr. Sci. Carceller, A. Blanco, M.C. Terencio, M.L. Ferrándiz and M.J. D16 II 1053.16 Use of calcium isotope tracers for Alcaraz. Bioiberica, S.A. and Univ. of Valencia, Spain. screening potential treatments for osteoporosis. E.E. Hohman, D7 I 1053.7 Bone turnover markers detect different B.R. Martin, L.D. McCabe, G.P. McCabe, G.S. Jackson, M. treatment effects within six weeks. E.R. Gertz, T. Rogers, E. Peacock and C.M. Weaver. Purdue Univ. and Indiana Univ. Demmer, D. Cheng, A. Villegas, M. Garrod and M. Van Loan. Sch. of Med. USDA, Davis, Univ. of California, Davis, Univ. of California, Berkeley and Univ. of California Merced.
347 NUTRITION TUESDAY
1054. FOOD SECURITY AND ITS CONNECTIONS TO D29 I 1054.13 Effect of prenatal and postpartum NUTRITION AND HEALTH food security status on breastfeeding initiation and duration in Massachusetts WIC participants 2001-2009. L.S. Brown, Poster R. Colchamiro, S. Edelstein and E. Metallinos-Katsaras. Simmons Col. and Massachusetts Dept. of Publ. Hlth., Boston. (Sponsored by: Community and Public Health RIS) D30 II 1054.14 Higher health services utilization and Tue. 7:30 am—Boston Convention & Exhibition Center, lower antiretroviral treatment-adherence in food insecure Exhibit Halls A-B HIV-infected adults in Miami, FL. M. Farsad, A. Campa, S.S. Martinez, Y. Li, S. Williams, S. Barr, T. Stewart, V. Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) Ramamoorthy, P. Greer, D. Gracia and M.K. Baum. R. D17 I 1054.1 Influence of leadership on the systematic Stempel Col. of Publ. Hlth. and Soc. Work and Col. of Med., identification of child food insecurity in schools. E.M. Fishbein, Florida Intl. Univ. and Borinquen Hlth. Care Ctr., Miami. M.S. Fram and E.A. Frongillo. Univ. of South Carolina. D31 I 1054.15 Healthy Eating Index in drug users D18 II 1054.2 Development of a two-item quick screen living in three U.S. East Coast cities. A. Tang, K. Hendricks, S. for household food insecurity assessment. M. Na, K. West, A.A. Skinner, K. Dong, H. Sheehan and C. Wanke. Tufts Univ. Sch. Shamim, S. Mehra, A. Labrique, H. Ali, L. Wu, R. Klemm and of Med. and Dartmouth Univ. Geisel Sch. of Med. P. Christian. Johns Hopkins Bloomberg Sch. of Publ. Hlth. and D32 II 1054.16 Household food insecurity and dietary JiVitA Proj., Bangladesh. intake among Hispanic women of childbearing age. A. Hilmers, D19 I 1054.3 Food insecurity in Palestinian and Iraqi T-A. Chen, D.C. Hilmers and K.C. Cullen. Johns Hopkins refugees in Lebanon. H. Ghattas, N.R. Sahyoun, K. Seyfert Bloomberg Sch. of Publ. Hlth. and Baylor Col. of Med. and A.J. Sassine. American Univ. of Beirut, Univ. of Maryland D33 I 1054.17 Persistent food insecurity is associated College Park and Sch. of Oriental and African Studies, London. with active coping strategies among low-income pregnant D20 II 1054.4 Iron deficiency and anemia are not Latinas. A. Hromi-Fiedler, A. Bermúdez-Millán, J. Leon, associated with food insecurity in pregnant women in the S. Segura-Pérez and R. Pérez-Escamilla. Yale Univ., Univ. United States: NHANES 1999-2008. C. Park and H.A. Eicher- of Connecticut Hlth. Ctr., Frank J. DiLoreto Dual Language Miller. Purdue Univ. Magnet Sch., New Britain and Hispanic Hlth. Council, Hartford. D21 I 1054.5 Food insecurity is not associated with D34 II 1054.18 Household food insecurity is positively body mass index among low-income African American adult associated with perceived discrimination among Cambodian residents in Baltimore City. N. Budd, D. Liu, A. Cuccia, B. pregnant women in Massachusetts. S. Chen, J.N. Peterman, Jock, J. Jeffries, K. Frick and J. Gittelsohn. Johns Hopkins R. Mouth and L. Cordeiro. Univ. of Massachusetts Amherst Bloomberg Sch. of Publ. Hlth. and Univ. of North Carolina and Cambodian Mutual Assist. Assn., Lowell, MA. Gillings Sch. of Global Publ. Hlth. D22 II 1054.6 Very low food security among children 1055. GLOBAL NUTRITION: OBESITY AND is associated with daily energy intake and diet quality. M.P. NUTRITION TRANSITION Burke, S.J. Jones, C.E. Blake, M.S. Fram and E.A. Frongillo. Univ. of South Carolina. Poster D23 I 1054.7 Functional limitation and chronic (Sponsored by: Global Nutrition Council (GNC)) diseases are associated with food insecurity among U.S. adults. B.J. Venci, S. Park and S-Y. Lee. Univ. of Cincinnati Tue. 7:30 am—Boston Convention & Exhibition Center, and Ctrs. for Dis. Control and Prevent. Exhibit Halls A-B D24 II 1054.8 Are physical activity and food insecurity associated with depressive feelings in U.S. adults? M. McNeill, Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) B.J. Venci, S. Park and S-Y. Lee. Univ. of Cincinnati and Ctrs. D35 I 1055.1 Overweight and obesity in children of for Dis. Control and Prevent. Arandas, Mexico during the nutrition transition. E.M. Vasquez- D25 I 1054.9 Food insecurity and food patterns in Garibay, L. Miranda Rios, E. Romero Velarde, M.E. Nuño Mexican-heritage children. A. Aguilera and L. Kaiser. Univ. of Cosio, R. Troyo Sanroman, L. Campos Barrera, E. Caro California, Davis. Sabido, J. Ramirez Diaz and M. Tremblay. Univ. of Guadalajara D26 II 1054.10 The distribution of food insecurity in and Inst. Alteño para el Desarrollo de Jalisco, Mexico and Univ. Mexico. T. Shamah Levy, V. Mundo-Rosas, L. Cuevas-Nasú, of Ottawa. M.C. Morales-Ruan and J.A. Rivera Dommarco. Natl. Publ. D36 II 1055.2 Effectiveness of “”Pilas””, a community- Hlth. Inst., Cuernavaca. based pilot intervention for chronic disease prevention in D27 I 1054.11 The effects of short-term participation Guatemalan school-age children. A.V. Chacon, P. Letona, in the Supplemental Nutrition Assistance Program on food M. Ramirez-Zea, J. Gittelsohn and B. Caballero. INCAP, security and dietary intake of low-income Massachusetts Guatemala City and Johns Hopkins Bloomberg Sch. of Publ. adults: a pilot study. C.W. Leung, S. Cluggish, E. Villamor, P.J. Hlth. Catalano, W.C. Willett and E.B. Rimm. UCSF, Proj. Bread- D37 I 1055.3 Mean total cholesterol/HDL-cholesterol The Walk for Hunger, East Boston, Univ. of Michigan Sch. of ratio and hs-CRP levels among foreign-born Afro Caribbeans Publ. Hlth., Harvard Sch. of Publ. Hlth. and Dana Farber Cancer and their United States-born counterparts in South Florida. E. Inst. Davis, F. Huffman and J. Dehpahlavan. Life Univ., GA and D28 II 1054.12 Food security and supplemental nutrition Florida Intl. Univ. Stempel Sch. of Publ. Hlth. assistance participation associated with home availability and preschool child consumption of 100% fruit juice. K. Yarbrough, E.A. Schilling and A.M. Ferris. Univ. of Connecticut Hlth. Ctr., East Hartford.
348 TUESDAY NUTRITION
D38 II 1055.4 Cultural definitions of healthy eating: D50 II 1055.16 Animal and plant protein intakes among views from poor Salvadorian communities. M. Fuster, E. different regional diets and their association with overweight Messer, R.F. Houser, P. Palma, H. Deman and O.I. Bermudez. and obesity. F. Zhai, H. Wang, B. Zhang and S. Du. Inst. of Friedman Sch. of Nutr., Tufts Univ. , PRESANCA, San Salvador Nutr. and Food Safety, Chinese Ctr. for Dis. Control, Beijing and and Tufts Univ. Sch. of Med. Univ. of North Carolina at Chapel Hill. D39 I 1055.5 Diet and other health-related behaviors D51 I 1055.17 Associations between wealth and of individuals with impaired glucose tolerance, cardiovascular weight status in Filipinos from birth to early adulthood. E. disease (CVD) or CVD risk: a global view from the NAVIGATOR Tzioumis and L.S. Adair. Univ. of North Carolina at Chapel study. C. Bales , S. Haffner, L. Thomas, J. Sun, T. Yates, K. Hill. Huffman, R. Califf, J. Toumilehto, J. McMurray, R. Holman, D52 II 1055.18 Fluid consumption by Mexican women M. Davies and W. Kraus. VA Med. Ctr. and DCRI, Durham, during pregnancy and first semester of lactation. H. Martinez. NC, Univ. of Texas Hlth. Ctr., Shavano Park, Univ. of Leicester, Children’s Hosp. “”Dr. Federico Gómez””, Mexico City and Danube Univ., Austria, Univ. of Glasgow and Univ. of Oxford. RAND Corp., Santa Monica, CA. D40 II 1055.6 A case study: nutrition and physical D53 I 1055.19 Waist circumference and waist:hip ratio activity environments of public childcare centers in Korea, predict hypertension and diabetes risk better than body mass Sweden, and U.S. J. Kim, N. Jackson, L.S. Elinder, D. index among Filipinos. C. Acuin and C. Duante. Univ. of the Singhru, L. Olsson, S. Bremberg and K. Kim. East Carolina Philippines, Cornell Univ., San Diego and Food and Nutr. Res. Univ., Karolinska Inst. and Sungkyunkwan Univ., South Korea. Inst., Taguig, Philippines. D41 I 1055.7 Understanding the formulation process D54 II 1055.20 Prospective analysis of the formulation of the Mexico and Spain school-feeding policies. K.Y. García , of country-level plans of a regional health partnership. W. E.A. Frongillo, A.C. Dresser, E. Orozco and G. Rodríguez. Gonzalez, E.A. Frongillo and J.F. Thrasher. Univ. of South Natl. Inst. of Publ. Hlth., Morelos, Mexico and Univ. of South Carolina. Carolina. D55 I 1055.21 Anthropometric differences and body D42 II 1055.8 A cardiovascular risk reduction composition among ethnic minorities in northern Vietnam. P.H. intervention in patients with hypertension and/or type 2 diabetes Nguyen, B. Katz, A.E. Lowe, H. Nguyen, T. Truong, H. Pham, in San José, Costa Rica and Chiapas, México. H. Martinez, S. Nguyen, G.A. Reinhart, K.B. Harding, L.M. Neufeld, M. Fort, A.L. Dengo, M. Castro, L. Peña, N. Alvarado, I. de R. Martorell and U. Ramakrishnan. Thai Nguyen Univ. of Beausset, M. Ramírez-Zea and S. Murillo. RAND Corp., Pharm. and Med., Vietnam, Intl. Food Policy Res. Inst., Hanoi, Children’s Hosp. of Mexico “”Dr. Federico Gómez””, INCAP, Columbia Univ., Emory Univ., The Mathile Inst., Dayton and Guatemala City, Univ. of Costa Rica Sch. of Nutr. and UNICACH, Micronutrient Initiative, Ottawa. Tuxtla Gutiérrez, Mexico. D56 II 1055.22 Process evaluation of a community- D43 I 1055.9 Maternal DHA supplementation during based pilot intervention for chronic disease prevention in pregnancy and plasma lipids and glucose levels in offspring Guatemalan school-aged children. P. Letona, J. Gittelsohn, at age 4y: follow-up of a randomized controlled trial. Y.Y. V. Chacon, M. Ramirez-Zea and B. Caballero. INCAP, Gutierrez-Gomez, U. Ramakrishnan, A.D. Stein, R. Martorell, Guatemala City and Johns Hopkins Bloomberg Sch. of Publ. C. Aguilar-Salinas, I. Romieu and J.A. Rivera. Natl. Inst. of Hlth. Publ. Hlth., Cuernavaca, Technol. of Monterrey, Mexico City, D57 I 1055.23 Preventing the global burden of type 2 Emory Univ., Natl. Nutr. Inst. Salvador Zubiran, Mexico City and diabetes by improving the quality of staple foods: The Global Intl. Agency for Res. on Cancer, Lyon. Nutrition and Epidemiologic Transition Initiative. J. Mattei, V. D44 II 1055.10 Physiological changes in Japanese Malik, N.M. Wedick, D. Spiegelman, F.B. Hu, W.C. Willett students during a one-year study abroad program in the United and H. Campos. Harvard Sch. of Publ. Hlth. and Univ. of States. C.R. Cahill and S. Stavrianeas. Willamette Univ., OR. Massachusetts Med. Sch. D45 I 1055.11 Associations between nutritional status D58 II 1055.24 Prevalence and determinants of of micronutrients and the growth, body composition and hyperhomocysteinemia in school aged children in rural Nepal. T biomarkers of metabolic risk in Chilean children. D. Lopez de K.J. Schulze, M. Yakub, P. Christian, C.P. Stewart and K.P. Romana, C. Corvalan, R. Uauy, G. Cediel, G. Duran and A.M. West, Jr. Johns Hopkins Bloomberg Sch. of Publ. Hlth. and U Palomino. Univ. of Chile. Univ. of California, Davis. E D46 II 1055.12 Spatial characteristics of BMI among D59 I 1055.25 The changing influence of wealth, women in Kurdistan, Iraq. K.M. Curtin, L. Pawloski, T.K. education and urbanization on overweight and obesity in Rasheed and H. Ahmad. George Mason Univ. and Univ. of Guatemalan women between 1995 and 2008. R. Kanter, M.P. Salahhadin, Iraq. Fort, M. Ramirez and R. Martorell. INCAP, Guatemala City D47 I 1055.13 Who is undernourished and who is and Rollins Sch. of Publ. Hlth., Emory Univ. overweight in Nigeria? O. Adeyemi, R.J. Stoltzfus, C.M. D60 II 1055.26 Relationships between overweight, Devine, D.L. Pelletier and P. Pinstrup-Andersen. Cornell inflammation, and iron status in women in the 2006 Mexican Univ. National Health and Nutrition Survey (ENSANUT). S.V. Luna, D48 II 1055.14 Why have NCDs received so little J.D. Haas, T. Shamah and S. Villalpando. Cornell Univ. and attention in Nigeria? O. Adeyemi, D.L. Pelletier, C.M. Devine, Natl. Inst. of Publ. Hlth., Cuernavaca. P. Pinstrup-Andersen and R.J. Stoltzfus. Cornell Univ. D61 I 1055.27 Physical activity and sedentary behavior D49 I 1055.15 The components of metabolic syndrome in South Indian adults: urbanicity, gender, and obesity. V.R. in relation to weight status in South Indians. A. Must, M. Chomitz, S.S. Prabhu, S. Thanikachalam, H. Vijayakumar, Thanikachalam, M. Begum, H. Vijayakumar, K. Chui, V. K.K.H. Chui, A. Must, O. Bermudez and M. Thanikachalam. Chomitz, O. Bermudez and S. Thanikachalam. Tufts Univ., Tufts Univ.,Boston, Sri Ramachandra Univ., India and The Ohio Boston, The Ohio State Univ. and Sri Ramachandra Univ., State Univ. India.
349 NUTRITION TUESDAY
D62 II 1055.28 Iron and diabetes risk among Filipino D73 II 1056.8 The healthy eating index and the women. A. Feranil, N. Lee, I. Bas, F. Largado and L. Adair. intestinal microbiome in HIV infection. G. Volpe, H. Sheehan, Univ. of San Carlos, Philippines and Univ. of North Carolina at A. Tang, C. Duffalo, D. Dinh, D. Landy, H. Ward, A. Kane and Chapel Hill. C. Wanke. Tufts Univ., Boston, Tufts Med. Ctr. and Univ. of D63 I 1055.29 Low calcium intake is associated with Miami. increased blood pressure among Filipino women. N.R. Lee, I. D74 I 1056.9 Purple-fleshed potatoes suppress Bas, F. Largado, J. Borja, P. Duazo and L. Adair. Univ. of San colon-systemic oxidative stress/inflammatory markers via Carlos Ofc. of Popul. Studies Fndn. Inc., Philippines and Univ. alternations in the gut bacterial signature. L. Reddivari, S.W. of North Carolina at Chapel Hill. Kim, S. Radhakrishnan, P. Yang, R. Knight and J. Vanamala. D64 II 1055.30 Low meats and sweets diet attenuates Colorado State Univ. , North Carolina State Univ., Univ. of Texas, the effect of overweight duration on glucose levels among MD Anderson Cancer Ctr. and Univ. of Colorado Boulder. Filipino women. P. Duazo, N. Lee, I. Bas, F. Largado, J. Borja D75 II 1056.10 Biotransformation of and L. Adair. Univ. of San Carlos-Ofc. of Popul. Studies Fndn. polymethoxyflavones by mouse and human colonic microflora. Inc, Philippines and Univ. of North Carolina at Chapel Hill. C. Ma, J. Zheng, T. Warnick, S. Leschine and H. Xiao. Univ. of D65 I 1055.31 A gauge repeatability and reproducibility Massachusetts Amherst. study applied to the measurements from the ENSANUT-2012 D76 I 1056.11 Past international residence and current anthropometric training. R. Garcia-Feregrino and A.D. gut microbiome. C. Frankenfeld, J.K. Poudrier, M. Sikaroodi, Quezada-Sanchez. Natl. Publ. Hlth. Inst., Cuernavaca. N. Waters, S. Shoemaker and P.M. Gillevet. George Mason Univ. 1056. NUTRITION AND THE MICROBIOME D77 II 1056.12 Sorghum-based dietary intervention enriches Faecalibacterium prausnitzii in fecal samples of Poster overweight individuals. D.V. Seidel, I. Martínez, S.S. Taddeo, R. Zoh, M.D. Haub, J. Walter and N.D. Turner. Texas A&M (Sponsored by: Medication Nutrition Council (MNC)) Univ., Univ. of Nebraska-Lincoln and Kansas State Univ.
Tue. 7:30 am—Boston Convention & Exhibition Center, D78 I 1056.13 The impact of long-term storage Exhibit Halls A-B on fermentability of human fecal bacteria. K. Racicot , S. Arcidiacono, C.Y. Chen and J. Soares. U.S. Army Natick Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) Soldier Ctr. and Tufts Univ., Boston. D66 I 1056.1 Soluble corn fiber modulates calcium D79 II 1056.14 High protein diet reduces food intake absorption by altering colonic microbiota. C.M. Whisner, C.H. and adiposity and alters GI microbiome. K. Pioli, C. Barbieri, I. Nakatsu, B.R. Martin, L.D. McCabe, G.P. McCabe and C.M. Cann, R. Mackie and J. Beverly. Univ. of illinois, Urbana and Weaver. Cornell Univ. and Purdue Univ. Univ. of North Carolina at Greensboro. D67 II 1056.2 Shifts in the fecal microbial community D80 I 1056.15 A study of the effects of the delivery composition are associated with dietary fiber solubility.F. system on the efficacy of the probiotic Bifidobacterium Yang, N. Chia, L.B. Schook and B.A. White. Univ. of Illinois at animalis subsp. lactis BB-12 in mediating colonic transit time Urbana-Champaign and Mayo Clin. and improving immune function. S. Holligan, R.F. Roberts, D68 I 1056.3 Increased gut microbiome diversity P.M. Kris-Etherton, J.A. Fleming, Z. Ba, K.E. Polizzano, E.J. following a high fiber Mediterranean style diet.N. Steinle, Furumoto and C.J. Rogers. Penn State. S. Cirimotch, K. Ryan, C. Fraser, A. Shuldiner and E. D81 II 1056.16 Use of urinary markers of the gut Mongodin. Univ of Maryland Sch of Med. and Baltimore VA microbiome in epidemiological studies: the case of bisphenol Med. Ctr. A concentrations in relation to enterolactone and enterodiol D69 II 1056.4 Compound seropositivity of neutralizing concentrations. C. Frankenfeld and P. Gillevet. George antibodies against adipogenic adenoviruses (ADV36+ and Mason Univ. ADV37+): no additive effect on overweight-obesity and on insulin resistance (IR-HOMA). The microbiome across the 1057. INTERVENTIONS FOR THE TREATMENT obesity and into the liver. G.M. Trovato, D. Catalano, G.F. AND PREVENTION OF NUTRITION-RELATED Martines, F.M. Trovato, A. Garozzo, C. Pirri and A. Tonzuso. DISEASES Univ. of Catania and Policlin.-VE, Catania, Italy. D70 I 1056.5 A 50:50 blend of insoluble and soluble Poster fibers added to enteral formula increases fermentation and prevents decline in gut bacteria. K. Koecher, W. Thomas and (Sponsored by: Medication Nutrition Council (MNC)) J. Slavin. Univ. of Minnesota, St. Paul and Minneapolis. Tue. 7:30 am—Boston Convention & Exhibition Center, D71 II 1056.6 Determining the gut microbiota- Exhibit Halls A-B independent effects of prebiotic fiber in diet-induced obese rats. M. Bomhof, H. Skochylas and R. Reimer. Univ. of Calgary, Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) Canada. D82 I 1057.1 The effect of one Hass avocado per day D72 I 1056.7 Effects of unsaturated fatty acids on cardiovascular disease risk factors. L. Wang, P.L. Bordi, on human gut microbiome profile in a subset of canola oil J.A. Fleming and P.M. Kris-Etherton. Penn State. multicenter intervention trial. S. Pu, H.R. Khazanehei, D.O. Krause, S.G. West, P.M. Kris-Etherton, D.J. Jenkins, B. Lamarche, P.J. Jones and E. Khafipour. Univ. of Manitoba, Penn State, Univ. of Toronto and Univ. Laval, Canada.
350 TUESDAY NUTRITION
D83 II 1057.2 Factors influencing theD96 I 1057.15 Lathosterol to cholesterol ratio in serum 25-hydroxyvitamin D level of pregnant women and their predicts cholesterol lowering response to plant sterol therapy newborns in Giessen, Germany. C. Wuertz, P. Gilbert, W. in a dual center, randomized, single-blind placebo controlled Baier and C. Kunz. Inst. of Nutr. Sci. , Germany, St. Josefs trial. D.S. MacKay, S. Gebauer, D. Baer and P. Jones. Univ. of Hosp. Balserische Fndn., Germany and Lab. Med. Dres. med. Manitoba and USDA, Beltsville. Wisplinghoff and Colleagues, Germany. D97 II 1057.16 A randomized controlled trial of genetic D84 I 1057.3 Insulin-sensitizing effects of an information on dietary intake. D. Nielsen and A. El-Sohemy. isocaloric diet containing soluble fiber-enriched flour in non- Univ. of Toronto and Nutrigenomix Inc., Toronto. obese non-diabetic subjects. M.M. Corsi Romanelli, S. D98 I 1057.17 Genetic control of serum 1,25 Briganti, S. Goggi, F. Ermetici, R. Zelaschi, C. Oggioni, D. dihydroxyvitamin D level under normal and low dietary calcium Ignaccolo, M. Orsi, L. Morricone and A.E. Malavazos. Univ. conditions. R.A. Replogle, L. Wang, M. Zhang and J.C. Fleet. of Milan and IRCCS Polyclin. San Donato, Milan. Purdue Univ. D85 II 1057.4 The association between diet and acne. J.C. Burris, W. Rietkerk and K. Woolf. NYU and New York 1058. PRENATAL NUTRIENT PROGRAMMING Med. Col. D86 I 1057.5 Effects of mango supplementation on Poster body weight and composition and clinical parameters of obese individuals. S.F. Evans, M. Meister, S. Peterson, P. Perkins- (Sponsored by: Medication Nutrition Council (MNC))
Veazie, S. Clarke, M. Payton, B. Smith and E. Lucas. Tue. 7:30 am—Boston Convention & Exhibition Center, Oklahoma State Univ. and North Carolina State Univ. Res. Exhibit Halls A-B Campus. D87 II 1057.6 Effect of the glutathione S-transferase Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) M1 and Tl polymorphism on the blood pressure, lipid profiles, D99 I 1058.1 Iron status is associated with auditory and the blood glucose of Korean subclinical hypertensive brainstem response measures in newborns. S. Lee, R. Guillet, patients after kale juice supplementation. M-H. Kang, J-H. M. Orlando, E. Cooper, E. Pressman, R.A. Queenan and Han, H-J. Lee and T.S. Kim. Hannam Univ., South Korea and K.O. O’Brien. Cornell Univ. and Univ. of Rochester Sch. of Pulmuone Hlth. & Living Co. Ltd., Seoul. Med. and Dent. D88 I 1057.7 Effectiveness of insulin pump use in D100 II 1058.2 Prebiotic fiber diet does not improve regulating blood glucose in type 1 diabetes mellitus patients. offspring ‘leaky gut’ from maternal low protein diet. M.C. Hallam N.M. Nemeh-Saad and A.M. Mistry. Sch. of Hlth. Sci., Easter and R.A. Reimer. Univ. of Calgary, Canada. Michigan Univ. D101 I 1058.3 A high protein:low carbohydrate diet D89 II 1057.8 Omega-3 fatty acid supplementation during pregnancy affects glucose metabolism in last trimester does not alter insulin sensitivity or serum adiponectin in healthy sows and fetuses and leads to intrauterine growth restriction. Hispanic women. S.E. Deemer, G.A. King, M.S. Hickey and C.C. Metges, S. Görs, I. Lang, K. Brüssow, H.M. Hammon, C.L. Melby. Colorado State Univ. and Univ. of Texas at El Paso. C. Rehfeldt and W. Otten. Leibniz Inst. for Farm Animal Biol., D90 I 1057.9 Moderate hyperglycemia and a blunted Dummerstorf, Germany. anabolic response to perioperative parenteral amino acids in D102 II 1058.4 An in vivo model for human fetal type 2 diabetes mellitus patients undergoing colorectal cancer adipose tissue development. J.A. Sanders, O. Onikoyi and surgery. A. Manjrekar, E. Nitschmann, R. Lattermann, T. P.A. Gruppuso. Rhode Island Hosp. and Alpert Med. Sch. of Schricker and L. Wykes. Sch. of Dietetics and Human Nutr., Brown Univ. McGill Univ. D103 I 1058.5 Iron status in multiples and their D91 II 1057.10 Anti-asthmatic of Lactobacillus neonates. Y. Ru, E.K. Pressman, R. Guillet, B.M. Cooper, P.J. paracasei subsp. paracasei NTU101 in OVA-induced asthmatic Katzman, S. Caveglia and K. O’Brien. Cornell Univ. and Univ. mice. W-K. Huang, J-H. Cai, M. Koriui and H-Y. Huang. Shih of Rochester Med. Ctr. T Chien Univ., Taiwan. D104 II 1058.6 Inrauterine growth retardation results in D92 I 1057.11 Long term supplement AGV- U altered metabolism and elevated preadipocyte proliferation in E isomaltooligosaccharides drink into water can moldulate the pigs. K.M. Ajuwon. Purdue Univ. gut microflora in rats. Y-C. Lin, C-P. Hsu, M-S. Peng, S-W. Lin D105 I 1058.7 Effect of Chdh deletion on mouse fetal and H-Y. Huang. Shih Chien Univ., Taiwan. neurogenesis and apoptosis. S. Lao, A.R. Johnson, M.G. D93 II 1057.12 A meta-analysis of randomized Mehedint, Y-W. Teng, S. Zhang and S.H. Zeisel. Univ. of controlled trials of Internet-based diabetes self management North Carolina at Chapel Hill Gillings Sch. of Global Publ. Hlth. intervention in patients with type 2 diabetes. Y. Kim and H. and Univ. of North Carolina at Chapel Hill, Kannapolis. McCollum. Louisiana Tech Univ. D106 II 1058.8 Vitamin D deficiency in cord plasma D94 I 1057.13 A moderate-fat diet with pistachios from multiethnic subjects living in the tropics. B.M. Halm, J.F. lowers small-dense LDL and improves markers of insulin Lai, I. Pagano, W. Cooney, R.A. Soon and A.A. Franke. Univ. sensitivity in subjects with moderately-elevated cholesterol of Hawaii Cancer Ctr., Kapiolani Med. Ctr. for Women and levels. S. Holligan, S.G. West, S.K. Gebauer, C.D. Kay and Children and Univ. of Hawaii John A. Burns Sch. of Med. P.M. Kris-Etherton. Penn State, USDA, Beltsville and Norwich Med. Sch., Univ. of East Anglia, U.K. D95 II 1057.14 The effect of more vegetable intake on risk factors for cardiovascular disease in hemodialysis patients. P.Y. Wu, Y-i.F. Chiu, Y-J. Lu, H-H. Chen, C-T. Su and S-H. Yang. Sch. of Nutr. and Hlth. Sci., Div. of Nephrol. and Dept. of Family Med., Taipei City.
351 NUTRITION TUESDAY
1059. RESEARCH WITH DIETARY SUPPLEMENTS D116 II 1060.6 When obesity begins: anthropometric AND BIOACTIVE COMPONENTS and demographic characteristics of California WIC child participants. P.C. Papathakis, A. Nazmi, S. Phelan and P. Poster Engle. Cal Poly San Luis Obispo. D117 I 1060.7 Nutritional deficits in juvenile end- (Sponsored by: Nutritional Epidemiology RIS) stage renal disease in a Guatemalan context. J. Casimiro, R. Tue. 7:30 am—Boston Convention & Exhibition Center, Lou-Meda, N.W. Solomons and K. Schümann. Tech Univ. Exhibit Halls A-B München and Roosevelt Hosp. and CeSSIAM, Guatemala City. D118 II 1060.8 Contrubution of snacks to total nutrient Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) intake by normal and overweight Puerto Rican children at D107 I 1059.1 Associations between urinary soy three different school levels. A.M. Preston, H. Venegas, R.M. isoflavones and inflammatory markers in adults in the Velez-Rodriguez, C.A. Rodriguez and N. Rodriguez. Univ. of United States in 2005-2008. H.L. Nicastro, A.M. Mondul, S. Puerto Rico-Med. Sci. Campus. Rohrmann and E.A. Platz. NCI, NIH, Rockville, Univ. of Zurich D119 I 1060.9 Association of body mass index and and Johns Hopkins Bloomberg Sch. of Publ. Hlth. waist circumference with metabolic alterations in children from D108 II 1059.2 Predictors of vitamin D status in subjects Arandas, Jalisco, Mexico. E. Romero-Velarde, E.M. Vásquez- that consume a vitamin D supplement. M.A. Levy, A. Dern, T. Garibay, L. Miranda-Rios and M.E. Nuño-Cosío. Univ. of Barker, E. Schneider, T. McKinnon, J. Robertson, J. Cuomo, Guadalajara, Mexico. T. Wood and B.M. Dixon. USANA Hlth. Sci., Salt Lake City and D120 II 1060.10 Factors associated with adherence to Orthoped. Specialty Hosp., Muray, UT. the dietary management of children and adolescents with type D109 I 1059.3 Comparative bioavailability of tableted 1 diabetes mellitus. E. Romero-Velarde, R.V. León-Robles, water-soluble olive polyphenols with and without phospholipid E. Vásquez-Garibay, C. Hunot-Alexander, B. Vizmanos- micelle incorporation in humans. J.A. Templeton, H. Goldfine, Lamotte and L. Aguirre-Salas. Univ. of Guadalajara and E. Schneider, T. McKinnon, J. Cuomo, B.M. Dixon and M.A. Hosp. Civil of Guadalajara. Levy. USANA Hlth. Sci. Inc., Salt Lake City. D121 I 1060.11 Serum levels of coenzyme Q10, D110 II 1059.4 Vitamin D supplement use by adult tocopherols, and C-reactive protein in adolescent girls and Canadians: sociodemographic correlates. S.I. Barr and T.J. premenopausal women. W. Chai, R. Novotny, R.V. Cooney, G. Green. Univ. of British Columbia. Maskarinec, A.A. Franke and L. Le Marchand. Logan Col., MO and Univ. of Hawaii. D122 II 1060.12 Body image perception among pre- 1060. ASSESSMENT OF CHILD AND ADOLESCENT adolescent children participating in a nutrition and physical NUTRITIONAL STATUS, GROWTH AND OBESITY activity intervention program. A. McCann, T. Kemmer, H. Wey and B. Jensen. South Dakota State Univ. Poster D123 I 1060.13 Higher dairy calcium intake compared to (Sponsored by: Nutritional Epidemiology RIS) other dietary sources of calcium is associated with decreased whole body and regional adiposity in adolescent girls. D.M. Tue. 7:30 am—Boston Convention & Exhibition Center, Vassallo, D. Laddu, V. Lee, R. Blew and S. Going. Univ. of Exhibit Halls A-B Arizona. Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) D124 II 1060.14 “...and we took the median of the three values”: optimal treatment of replicate measurements in D111 I 1060.1 Iodine and iron deficiency and parasites anthropometric studies. E. Villamor and R.J. Bosch. Univ. of in children of Arandas, Mexico during the nutrition transition. Michigan Sch. of Publ. Hlth. and Harvard Sch. of Publ. Hlth. E.M. Vasquez-Garibay, L.R. Campos Barrera, E. Romero D125 I 1060.15 Can teens accurately report their Velarde, M.E. Nuño Cosio, R. Troyo Sanroman, L. Miranda weight, height, and waist and hip circumferences? G.S. Siapco, Rios, F. Napoles Rodriguez, A.R. Del Angel and F. Velarde. S. Alomairah and J. Sabate. Sch. of Publ. Hlth., Loma Linda Univ. of Guadalajara and Inst. Alteño para el Desarrollo de Univ. Jalisco, Mexico. D126 II 1060.16 Infant dietary intake is associated with D112 II 1060.2 Beyond calcium status obesity would weight gain from 1 to 12 months of age. S. Gallo, C. Vanstone, impair bone mineralization in school age children of both sexes: C. Rodd and H.A. Weiler. Sch. of Dietetics and Human Nutr., preliminary report. M.E. Rio and H. Dupraz. Univ. of Buenos McGill Univ. and Montreal Children’s Hosp. Aires. D127 I 1060.17 Regular soy intake supports normal D113 I 1060.3 What are U.S. children under two growth of teens and has no effect on risk of obesity. J. Sabaté, eating? Results from NHANES (2003-2008). S. Keim, A.M. T. Norkunas, L. Huey and G. Segovia-Siapco. Loma Linda Branum and J. Peck. Nationwide Children’s Hosp., The Ohio Univ. State Univ. Col. of Med., Ctrs. for Dis. Control and Prevent., D128 II 1060.18 Fructose, sweetened food and beverage Hyattsville, MD. intake and metabolic markers in children. C. County, A. D114 II 1060.4 Vitamin D status, sun exposure and Thomas, P.M. Catalano and N.L. Nock. Case Western lipid profile among adolescents living in São Paulo, Brazil. K.V. Reserve Univ. and MetroHlth. Med. Ctr. Giudici, M.A. Lopes, D.M.L. Marchioni, R.M. Fisberg and D129 I 1060.19 Accuracy of weight perception following L.A. Martini. Univ. of São Paulo. KidQuest intervention in rural South Dakota elementary D115 I 1060.5 Infant feeding practices and challenges: students. T.M. Kemmer, H. Wey, A. McCann and B. Jensen. a pilot-study in Lebanon. N. Hwalla, F. Naja, T. Fossian, D. South Dakota State Univ. Zebian and L. Nasreddine. American Univ. of Beirut.
352 TUESDAY NUTRITION
D130 II 1060.20 A prospective study of body image 1061. NUTRITION WITHOUT BORDERS: dissatisfaction and BMI change in school children. O. Duchin, EPIDEMIOLOGIC METHODS IN EXAMINING M. Mora-Plazas, C. Marin, C. Mendes de Leon, J.M. Lee, A. HEALTH DISPARITIES AND NUTRITION Baylin and E. Villamor. Univ. of Michigan Sch. of Publ. Hlth., OUTCOMES IN DIVERSE POPULATIONS Res. Fndn. for Nutr. and Hlth., Bogota and Univ. of Michigan Hlth. Systs. Poster D131 I 1060.21 Selecting items of a food behavior checklist for the development of nutrition quotient for children in (Sponsored by: Nutritional Epidemiology RIS) Korea. M-H. Kang, J-S. Lee, H-Y.P. Kim, S. Kwon, Y-S. Choi, Tue. 7:30 am—Boston Convention & Exhibition Center, H.R. Chung, T-K. Kwak, H-J. Lee and Y-H. Cho. Hannam Exhibit Halls A-B Univ., FANSA, Seoul, Yongin Univ., Daegu Univ., Nutr. for the Future Inc., Seoul, Yonsei Univ., South Korea and Amway Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) Korea, Seoul. D140 I 1061.1 The Hispanic dietary mosaic: assessing D132 II 1060.22 Early rapid weight gain is associated the diet of women in Puerto Rico in the Atabey Study. M. with overweight and obesity at 8 years in a breastfed population Schelske-Santos, C.M. Nazario, R.V. Rosario Rosado, I. in Peru. M.E. Penny and M. Marin. Nutr. Res. Inst., Lima, Peru. Mansilla-Rivera, J. Hernández, F.A. Ramírez Marrero, S. D133 I 1060.23 Development of a nutrition quotient McCann and J.L. Freudenheim. Univ. of Puerto Rico-Rio equation modeling for children and the evaluation of its Piedras, Univ. of Puerto Rico-Med. Sci., Roswell Park Cancer construct validity in Korea. H-Y.P. Kim, S. Kwon, J-S. Lee, Y-S. Inst. and Univ. at Buffalo. Choi, H.R. Chung, T-K. Kwak, J. Park, H-J. Lee and M-H. D141 II 1061.2 Sociodemographic, clinical, and lifestyle Kang. Yongin Univ., Hannam Univ., FANSA, Seoul, Daegu factors associated with prostate cancer aggressiveness in a Univ., Nutr. for Future Inc., Seoul, Yonsei Univ., South Korea population-based study. T.M. Vance, Y. Wang, L.J. Su, E.T.H. and Amway Korea, Seoul. Fontham, J.T. Bensen, J.L. Mohler, M-H. Chen and O.K. D134 II 1060.24 Using principal component analysis to Chun. Univ. of Connecticut, NCI, NIH, LSU Hlth. Sci. Ctr., New characterize dietary patterns in children from Uruguay. Y. Lee, Orleans, Sch. of Med., Univ. of North Carolina at Chapel Hill P.Y. Hsiao, E. Queirolo, F. Peregalli and K. Kordas. Penn and Roswell Park Cancer Inst. State and Catholic Univ. of Uruguay. D142 I 1061.3 Dietary total antioxidant capacity and D135 I 1060.25 Anthropometric measurements, dietary prostate cancer tumor stage among African and Caucasian intakes, mealtime and other behaviors of children with autism. Americans in a population-based study. T.M. Vance, Y. Wang, S.M. Ekvall, P. Fugazzi, F. Stevens and V. Ekvall. Univ of L.J. Su, E.T.H. Fontham, J.T. Bensen, J.L. Mohler, M-H. Chen Cincinnati and Cincinnati Children’s Hosp. Med Ctr. and O.K. Chun. Univ. of Connecticut, NCI, NIH, LSU Sch. of D136 II 1060.26 Dietary intakes of children from birth to Publ. Hlth., New Orleans, Sch. of Med., Univ. of North Carolina 24 months: What We Eat in America NHANES 2007-2010. D.G. at Chapel Hill and Roswell Park Cancer Inst. Rhodes, M.E. Adler, J.C. Clemens, J.D. Goldman and A.J. D143 II 1061.4 Vitamin deficiencies are both risk Moshfegh. USDA, Beltsville. factors and protective against diverse urogenital and intestinal D137 I 1060.27 Fat imaging via magnetic resonance infections in pregnant Ngabe women from Panama. M.E. Scott, imaging in young children (ages 1-4 years) without sedation. D. Gonzalez-Fernandez, E. Murillo, O. Sinisterra and K.G. G.E. Shearrer, B. House, J. Luci and J. Davis. Univ. of Texas Koski. Sch. of Dietetics and Human Nutr., McGill Univ., Fac. of at Austin. Med., Univ. of Panama and Panamanian Ministry of Hlth. D138 II 1060.28 Vitamin D, calcium, potassium and calorie intakes associated with distinct breakfast patterns in children (NHANES 2001-2008). E.E. Quann, V.L. Fulgoni III 1062. NUTRITION EDUCATION and N. Auestad. Natl. Dairy Council, Rosemont, IL and Nutr. Poster Impact LLC, Battle Creek, MI. T D139 I 1060.29 Beverage consumption among school- (Sponsored by: Nutrition Education RIS) age children of different race/ethnic backgrounds from the U National Health and Nutrition Examination Survey. E.E. Tue. 7:30 am—Boston Convention & Exhibition Center, E Quann, N. Auestad and V.L. Fulgoni III. Natl. Dairy Council, Exhibit Halls A-B Rosemont, IL and Nutr. Impact LLC, Battle Creek, MI. Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) D144 I 1062.1 Efficacy of interactive whiteboards as teaching tools in the nutrition education of 1st and 2nd grade students. L. Maddox, T. Crook, D. Gonzales and R. Hakkak. POSTER PRESENTERS: Univ. of Arkansas for Med. Sci. UPLOAD YOUR POSTER D145 II 1062.2 The effects of a 3-year worksite health promotion program in male workers with metabolic syndrome. Where: E-Poster Counter, Sun. – Tue. Hall A; Wed. Hall C S.W. Cho, J-Y. Kang, T-I. Choi and Y-K. Park. Grad. Sch. of Deadline: Tue., April 23, 5:00 pm; Wed., April 24, 3:00 pm East-West Med. Sci. , Kyung Hee Univ., South Korea and Korea Hydro & Nuclear Power Co. Ltd., Seoul. Uploaded posters will be available online to all D146 I 1062.3 Weight control attitude and nutrition registered attendees following the meeting at knowledge of Korean high school students by BMI. K.J. Chang www. experimentalbiology.org and H-Y. Cho. Inha Univ., South Korea.
353 NUTRITION TUESDAY
D147 II 1062.4 A comparative study of unbalanced D160 I 1063.3 Using focus groups to inform an eating habit and dietary pattern of middle school students in intervention to promote adoption of the DGA among African Incheon area, Korea. Y. Kim and E. Lee. Inha Univ., South American children in the lower Mississippi Delta. B.B. McGee, Korea. V. Richardson, G. Johnson and C. Johnson. Southern Univ. D148 I 1062.5 Dietary patterns of Korean elementary and A&M Col. school students in Incheon region. Y. Kim and B.H. Cho. Inha D161 II 1063.4 Food choices for 2-5-year-old children Univ., South Korea. in California childcare: comparing 2008 and 2012. S. Sharma, D149 II 1062.6 Efficacy of an evidence-based food S. Yoshida, E. Braff-Guajardo and L.D. Ritchie. Univ. of guide for vegetarians and vegans. J.R. Knurick, L. Fladell and California, Berkeley, Samuels and Assocs., Oakland and C.S. Johnston. Arizona State Univ. California Food Policy Advocates, Oakland. D150 I 1062.7 Innovation in dietetic internship D162 I 1063.5 2010-2011 USDA fresh fruit and education at Iowa State University. R.S. MacDonald, J.A. vegetable program improved Indiana elementary students’ Anderson, E. Bergquist, J.S. Johnson and L.S. Kruzich. consumption of fruit. L. Huang, Y-C. Lin, E. Foland, Y. Bai, Y. Iowa State Univ. Liu and A.D. Fly. Sch. of Publ. Hlth., Indiana Univ., Indiana D151 II 1062.8 Dietary behavior and nutrition Dept. of Educ., Indianapolis and Montclair State Univ. knowledge of Korean elementary students. K.J. Chang and D163 II 1063.6 Associations between knowledge and J-s. Jang. Inha Univ., South Korea. attitudes about sports drinks and sports drink intake among D152 I 1062.9 iCook: developing a 4-H curriculum for U.S. youth. D. Zytnick, S. Park and S.J. Onufrak. Ctrs. for Dis. youth and adults. L. Franzen-Castle, M. Krehbiel, A. White, D. Control and Prevent. Mathews, K. Yerxa, S. Colby, A. Donaldson, K. Kattelmann, D164 I 1063.7 Medical student initiative of monitoring A. Koens, M. Olfert and S. Flanagan. Univ. of Nebraska- USDA nutritional guidelines adherence with novel application of Lincoln, Univ. of Maine, Univ. of Tennessee, Knoxville, South digital photography in elementary school meals. D. Monlezun, Dakota State Univ. and West Virginia Univ., Morgantown and A. Rodman, B. Telsey, B. Leong, L. Abu-Shamat, D. Kay, D. Martinsburg. Green, L. Sarris and T. Harlan. Tulane Univ. and Tulane Univ. D153 II 1062.10 A web-based food value analysis Sch. of Med. application to compare foods at different levels of processing. D165 II 1063.8 The relationship between infant-feeding M.K. Muth, S. Karns, M. Coglaiti, M. Zmuda, M. Koyanagi, attitudes and practices and infant weight at 2 and 4 months of K. Duffey, C. Dunn, H. Jensen and C. Gregory. RTI Intl., age. K.M. Bower, J.C. Nicklas, A.N. Sberna, J.J. Waller, J.L. Research Triangle Park, Virginia Tech, North Carolina State Burney, B.P. Greer and K.F. Kavanagh. Univ. of Tennessee, Univ., Iowa State Univ. and Econ. Res. Svc., Washington, DC. Knoxville. D154 I 1062.11 White potato consumption is positively D166 I 1063.9 Use of digital messages to increase associated with potassium intake. M.L. Storey and P. parental engagement in an after-school obesity prevention Anderson. Alliance for Potato Res. & Educ., McLean, VA. program. L. Miesel, M. Spence, C. Perry-Burst, A. McDonald D155 II 1062.12 Korean middle school students’ dietary and J. Beason. Univ. of Tennessee, Knox Cty. Schs. and habits and degree of satisfaction with school meals. Y. Kim and Tennova Healthcare, Knoxville. H.Y. Kim. Inha Univ., South Korea. D167 II 1063.10 After-school obesity prevention D156 I 1062.13 Training and professional development programs: are engaged parents a myth or reality? M. Spence, barriers and opportunities in programs participating in the A. McDonald and C. Perry-Burst. Univ. of Tennessee, National School Lunch Program. A.M. Jones, M. Punia, S. Knoxville and Knox County Schs., TN. Young, C. Chase and S. Zidenberg-Cherr. Univ. of California, D168 I 1063.11 Food as a reward and weight status Davis, and California Dept. of Educ. and Dairy Council of in children with autism. L. Bandini, C. Curtin, S. Anderson, California, Sacramento. S. Philips and A. Must. Univ. of Massachusetts Med. Sch., D157 II 1062.14 Motivating Me: Healthy Minds, Healthy Boston Univ., The Ohio State Univ. Col. of Publ. Hlth. and Tufts Bodies: development of a psychoeducational program for Univ. Sch. of Med. obese children. A.M. Maia and A.A. White. Univ. of Maine. D169 II 1063.12 Parent reports of young children’s sensory characteristics are related to children’s food 1063. PREVENTING CHILDHOOD OBESITY neophobia. S.L. Johnson, P. Davies, R.E. Boles, W. Gavin and L. Bellows. Univ. of Colorado Anschutz Med. Campus and Poster Colorado State Univ. D170 I 1063.13 Perceptions of factors and messages (Sponsored by: Nutrition Education RIS) related to childhood obesity among Mexican-origin parents.
Tue. 7:30 am—Boston Convention & Exhibition Center, L.E. Vera-Becerra, A. Aguilera, L. Kaiser, R. Manzo and Exhibit Halls A-B A. de la Torre. Sch. of Med. and Nutr., Univ. of Guanajuato, Mexico and Sch. of Educ., Univ. of California, Davis. Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) D171 II 1063.14 Strength of association of dietary D158 I 1063.1 Withdrawn. factors and physical activity with obesity and body fat in school D159 II 1063.2 Fathers’ buying habits related to children in Mexico City. D. Barrera, M. Perez-Rodriguez, N. increased sweetened beverage consumption in preschool Vega, E. Gamez, G. Leyva, F. Pfeffer and A. Ortiz. Mexican children. A.S. Coleman and A.M. Ferris. Univ. of Connecticut, Hlth. Fndn., Tlalpan. East Hartford. D172 I 1063.15 Obesity prevention in preschool-aged children: the importance of sleep. D. Golem, J. Martin-Biggers, J. Worobey and C. Byrd-Bredbenner. Col. of Hlth., Human Svcs. and Sci., Ashford Univ., CA and Rutgers, The State Univ. of New Jersey.
354 TUESDAY NUTRITION
D173 II 1063.16 Relationship of body mass index to D184 II 1064.2 Teaching 3rd & 4th year medical screen time in head start participants in Central Arkansas. B. students how to cook: an innovative approach to balance Timmerman, T. Crook, D. Gonzales, L. Maddox, K. Smith, C. lifestyle modification and medication therapy in chronic disease Feild and R. Hakkak. Univ. of Arkansas for Med. Sci. management. B. Leong, L. Abu-Shamat, D. Kay, D. Monlezun, D174 I 1063.17 Healthy lifestyle telephone group L. Sarris and T. Harlan. Tulane Univ. counseling for children and their families. C.A. Gibson, R.J. D185 I 1064.3 Increasing medical student knowledge Sol, S. Staubach, J.L. Greene, J.H. Lee, C.C. Pritchard, D.K. of the urban nutrition climate through an orientation bus tour Sullivan and D. Davis. Univ. of Kansas Med. Ctr., Univ. of and urban nutritition scavenger hunts. K. Ireland, M. Beste, V. Kansas and Blue Cross, Kansas City, MO. Halls, R. Jordan, C. Lenders and E. Hardt. Boston Univ. Sch. D175 II 1063.18 iCook: lessons learned about recruiting of Med. and Sargent Col. of Hlth. and Rehabil. Sci. youth and their primary adult food preparers for a 4-H cooking D186 II 1064.4 Physician attitudes towards individuals intervention. M.D. Olfert, E. Smith, S. Flanagan, S.E. Colby, who are overweight. S. Garner, D. Gonzales, T. Crook and R. K. Shanklin, A.A. White, D. Mathews, K. Yerxa, L. Franzen- Hakkak. Univ. of Arkansas for Med. Sci. Castle, M. Krehbiel, K.K. Kattelmann and A. Koens. West D187 I 1064.5 Dietary supplement education for the Virginia Univ., Univ. of Tennessee, Knoxville, Univ. of Maine, military: an education module for healthcare providers. S. Univ. of Nebraska, Scottsbluff and South Dakota State Univ. Attipoe, R. Costello, M. Kohlmeier and P. Deuster. Uniformed D176 I 1063.19 Simple Suppers: a family nutrition Svcs. Univ. of Hlth. Sci., ODS, NIH and Univ. of North Carolina education and cooking program delivered in the daycare setting at Chapel Hill. designed to improve diet quality in preschool aged children. A. D188 II 1064.6 Online and campus students have Wagner, A. Rose, J. Kennel and C. Gunther. The Ohio State positive perceptions of an open educational resource, the Univ. Kansas State University Human Nutrition (HN 400) Flexbook. D177 II 1063.20 Dairy intake and obesity risk among B. Lindshield and K. Adhikari. Kansas State Univ. teens. M. Nezami , G. Siapco and J. Sabate. Loma Linda Univ. D189 I 1064.7 Nutrition, Behavior, and Mental Health: D178 I 1063.21 The effects of dairy intake among a unique undergraduate course at the intersection of food preschool aged girls and boys on their weight status. T.R. and mood. L. Chen and L.E. Murray-Kolb. Johns Hopkins Cohen, T.J. Hazell, S. Jean-Philippe, T. Pham, C.A. Vanstone, Bloomberg Sch. of Publ. Hlth. and Penn State. C.R. Rodd and H.A. Weiler. Sch. of Dietetics and Human Nutr., D190 II 1064.8 Dentists’ dietary perception and McGill Univ., Univ. of Lethbridge, Canada, Children’s Hosp. of practice patterns in a dental practice-based research network. Eastern Ontario Res. Inst. and Montreal Children’s Hosp. Y. Yokoyama, N. Kakudate, F. Sumida, Y. Matsumoto, G.H. D179 II 1063.22 Inclusion of peers in a school-based Gilbert and V.V. Gordan. Japan Soc. for the Promotion of obesity intervention. C.A. Johnston, J. Moreno, A. El- Sci.. Suita, Stanford Univ. Sch. of Med., Nagayama Family Mubasher, M.A. Papaioannou and D. Woehler. Baylor Col. of Dent. Clin., Sapporo, Wing Town Dent. Clin., Okazaki, Univ. of Med. and The Cluthe & William B. Oliver Fndn., Houston. Alabama at Birmingham and Univ. of Florida. D180 I 1063.23 Adherence to a multi-component weight management program for Mexican American adolescents. C.A. 1065. NUTRITION TRANSLATION Johnston, M.A. Papaioannou, J.P. Moreno, A. El-Mubasher and J.P. Foreyt. Baylor Col. of Med. Poster D181 II 1063.24 The impact of metabolic syndrome on child weight outcomes in pediatric obesity program for Mexican (Sponsored by: Nutrition Translation RIS)
Americans. C.A. Johnston, J.P. Moreno, L. Green, A. El- Tue. 7:30 am—Boston Convention & Exhibition Center, Mubasher, B.K. McFarlin and J.P. Foreyt. Baylor Col. of Med. Exhibit Halls A-B and Univ. of North Texas. D182 I 1063.25 The impact of acculturation level on Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) weight status and weight outcomes in Mexican American D191 I 1065.1 Perceptions and use of nutrition labeling T children. C.A. Johnston, R. Cameron, S. Lyons, J.P. Moreno information. W.Y. Juan, Y. Zhang, M. Kantor and M. Ali. USDA, and M.A. Papaioannou. Baylor Col. of Med., Sam Houston U College Park, MD. E State Univ. and George Washington Univ. D192 II 1065.2 Assessment of variation in methods to determine reported iron content of nutrition labels of 1064. EDUCATION AND TEACHING IN MEDICAL AND commercial dark chocolate bars. R. Giusti and A. Kazaks. OTHER PROFESSIONAL SCHOOLS Bastyr Univ., WA. D193 I 1065.3 Impact of prompts with diet self- Poster assessment tools in determining calcium intake in college- aged adults. K. Plawecki, C.K. Kwan and K. Chapman- Tue. 7:30 am—Boston Convention & Exhibition Center, Novakofski. Benedictine Univ., IL, Univ. of Illinois, Urbana and Exhibit Halls A-B The Univ. of Hong Kong. Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) D194 II 1065.4 Expert recommendations for consumption frequencies of specific foods.J.Y. Andrews D183 I 1064.1 Dietary intake of sleep-deprived, on- Chavez, J. Konick, C. Davis, E. Marino-Costello, P. Connell call anesthesiology residents. M.K. Taylor, C.A. Gibson, G.K. and R.F. Houser. Tufts Univ. Friedman Sch. of Nutr. Sci. and Unruh, L.T. Ptomey, K.R. Spaeth and D.K. Sullivan. Univ. of Policy, Tufts Univ. and Connecticut Col. Kansas Med. Ctr.
355 NUTRITION TUESDAY
D195 I 1065.5 Development of 2010 Dietary Guidelines D211 I 1065.21 Assessing issue awareness and for Americans menus for a randomized controlled-feeding study. messaging on purchasing behavior of fresh fruits and N. Schroeder, M-S. Kang, Y. Kim, G. Ha, Y-H. Park, H-R. Kim, vegetables in low-income populations. Y. Huang, B. Wuchner, A. Yates and B. Caballero. USDA, Beltsville, Rural Develop. S. Thomas, E. Park, I. Edirisinghe and B. Burton-Freeman. Admin., Suwon, South Korea and Johns Hopkins Univ. Illinois Inst. of Technol. D196 II 1065.6 Child and adolescent dietary intake of D212 II 1065.22 Bioaccessibilities of K, P, Fe and B produce with high pesticide exposure. E.K. Kobernik and A.M. minerals in oleaster flour as a novel food ingredient. Y. Sahan, Branum. Natl. Ctr. for Hlth. Stats., Hyattsville, MD. A. Cansev, G. Celik and D. Gocmen. Uludag Univ. and Bursa D197 I 1065.7 School children’s acceptance of fat-free, Test and Analysis Lab., Turkey. low added sugars flavored milk.B.A. Yon and R.K. Johnson. D213 I 1065.23 Antioxidant properties and their Univ. of Vermont. bioaccessibility of blessed thistle under different processed D198 II 1065.8 Dairy products consumption in French treatments. Y. Sahan and D. Dulger. Uludag Univ. and Istanbul children in 2010. C. Marmonier, E. Chazelle and B. Coudray. Aydýn Univ., Turkey. CNIEL and CERIN, Paris. D214 II 1065.24 Sandwiches are an important source of D199 I 1065.9 Is there fruit in that? Children are misled both nutrients to increase and nutrients to reduce: results from by television food advertisements. R. Heller, A. Berhaupt- what we eat in America, NHANES 2009-2010. R.S. Sebastian, Glickstein, J. Martin-Biggers and C. Byrd-Bredbenner. C. Wilkinson Enns, J.D. Goldman and A.J. Moshfegh. Rutgers, The State Univ. of New Jersey. USDA, Beltsville. D200 II 1065.10 Energy implications of eating out and D215 I 1065.25 Anti-hyperglycemic effect of arginyl- other diet behaviors in Filipino adults. I.N. Bas, F.G. Largado, fructose and arginyl-fructosyl-glucose in db/db mice model. J.B. Borja, N.R. Lee and L.S. Adair. Univ. of San Carlos Ofc. of K-S. Ha, S-H. Jo, E. Apostolidis, C.M. Lee, Y-H. Kim, M.S. Popul. Studies Fndn., Philippines and Univ. of Northa Carolina Lee, H-D. Jang and Y-I. Kwon. Hannam Univ., South Korea, at Chapel Hill. Framingham State Univ., Univ. of Rhode Island and Chungnam D201 I 1065.11 Comparison of main contributors to Natl. Univ., South Korea. dietary fiber and whole grain in Americans’ diet: NHANES D216 II 1065.26 Resistant starch as a novel food 2003-2010. S. Kranz, K.W. Dodd, W. Juan and L.K. Johnson. ingredient in human nutrition. D. Gocmen and A.N. Dundar. Purdue Univ., NCI, NIH, Rockville, FDA, College Park, MD and Uludag Univ. Fac. of Agr. and Vocational Sch. of Y. Sehir Ibrahim USDA, Grand Forks. Orhan, Turkey. D202 II 1065.12 Organic and genetically modified food: D217 I 1065.27 Oat usage in food production as a consumer beliefs and behavior. J.C. Panchalk and A.M. bioactive component source. D. Gocmen, E. Aydin, A.Y. Kilci Mistry. Sch. of Hlth. Sci., Eastern Michigan Univ. and M. Aydin. Uludag Univ. Fac of Agr. and Vocational H.S. of D203 I 1065.13 Relationship between green eating and Keles, Turkey. environmental attitudes and behaviors in college students. D218 II 1065.28 Evidence of revising calcium dietary E. Vandeputte, J.T. Nash, K. Weller, G.W. Greene and I.E. reference intakes for Korean elderly. Y-S. Choi, H. Joung and Lofgren. Univ. of Rhode Island. J. Kim. Daegu Univ., South Korea and Seoul Natl. Univ. D204 II 1065.14 The “”Green Eating”” project: a pilot intervention to promote sustainable and healthy eating in 1066. OBESITY: CARBOHYDRATE INTAKE AND college students. J. Nash, K. Eastman, N. Mundorf and G. WEIGHT MANAGEMENT Greene. Univ. of Rhode Island. D205 I 1065.15 Green eating and dietary quality in Poster university students. G.A. Brown, J. Arts, J.T. Nash, I.E. Lofgren and G.W. Greene. Univ. of Rhode Island. (Sponsored by: Obesity RIS) D206 II 1065.16 Environmentally conscious behavior at Tue. 7:30 am—Boston Convention & Exhibition Center, three Northeastern universities. S.J. McPartland, J.T. Nash, K. Exhibit Halls A-B Melanson, R. Hall, A.A. White, T.M. Horacek and G. Greene. Univ. of Rhode Island, Univ. of Maine and Syracuse Univ. Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) D207 I 1065.17 HSCCC isolation and characterization D219 I 1066.1 The ability of spices to increase of walnut polyphenols with antioxidative and lipolytic activity. vegetable intake among overweight adults, measured by M.H. Grace, S.A. Neff, C. Warlick, E. Ayoub, D. Esposito, M. a universal eating monitor. Z. Li, L.K. Brahe, A. Zerlin, A. Wilson, S. Komarnytsky and M.A. Lila. North Carolina State Rheinwald-Jones, M. Krak, G. Thames and D. Heber. UCLA Univ., Kannapolis. and Univ. of Copenhagen. D208 II 1065.18 Nutrient composition of regular and low D220 II 1066.2 Inclusion of a high carbohydrate sodium bacon. J. Dai and L. Thompson. Texas Tech Univ. meal with nutrition education decreases weight and body fat D209 I 1065.19 The relevances of metabolic syndrome more than education alone. M.C. Caamaño, D. Ronquillo, with dietary habit and lifestyle in Korean middle-aged women. O.P. García, G. Martínez-Peña, S. García-Padilla and J.L. H.J. Lee and K-H. Lee. Changwon Natl. Univ., South Korea. Rosado. Autonomous Univ. of Querétaro, Cindetec A.C. and D210 II 1065.20 Food insecurity and its association Kellogg de Mexico, Querétaro. with risky behaviors among tTanzanian adolescents. J. D221 I 1066.3 Iin vitro digestive enzyme inhibitory Klingensmith and L.S. Cordeiro. Univ. of Massachusetts effects of eight common spices and herbs. T. Moss-Pierce, Z. Amherst. Tu and A. Jiang. McCormick and Co. Inc., Hunt Valley, MD.
356 TUESDAY NUTRITION
D222 II 1066.4 High fructose corn syrup-sweetened D233 II 1067.10 A high protein diet results in moderate cola and the hypothalamus: a dose-response fMRI study. S. renal and hepatic damage but improves body size, glucose Hudgins, A. Smaliy, W. Zhan, J.L. Leger, S. Gebauer, D.J. handling and haptoglobin levels in diet-induced obese rats. Baer and T.W. Castonguay. Univ. of Maryland College Park J.G. Devassy, N. Ibrahim, C.G. Taylor, P. Zahradka and H.M. and USDA, Beltsville. Aukema. Univ. of Manitoba and Canadian Ctr. for Agri-Food D223 I 1066.5 Sugar sweetened beverage Res. in Hlth. and Med., Winnipeg. consumption is higher in normal weight than overweight and D234 I 1067.11 HbA1c levels in non-diabetic overweight obese adolescents: implications for future increased prevalence and obese subjects. L. Zago, A. Weisstaub, M.C. Masselli, of obesity. M. Rodriguez, R. Ortiz, P. Montez and S. Weffer. V. Ortiz, A.L. Felipoff, H. Dupraz, C. Perdomo, M.E. Rio, N. Univ. of California, Merced and Northern Illinos Univ. Presner, S. Rivera and C. González Infantino. Fac. of Pharm. and Biochem, Univ. of Buenos Aires, Clin. Hosp. and CONICET, 1067. OBESITY: CHRONIC DISEASES Buenos Aires. D235 II 1067.12 Changes in cardiovascular risk factors Poster after 4-week consumption of two diet patterns: Korean and 2010 U.S. Dietary Guidelines. N. Schroeder, M-S. Kang, Y. (Sponsored by: Obesity RIS) Kim, G. Ha, Y-H. Park, H-R. Kim, A. Yates and B. Caballero.
Tue. 7:30 am—Boston Convention & Exhibition Center, USDA, Beltsville, Rural Develop. Admin., Suwon, South Korea Exhibit Halls A-B and Johns Hopkins Univ. D236 I 1067.13 Response of serum osteocalcin to Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) caloric restriction with and without exercise in post-menopausal D224 I 1067.1 Health behaviors index for women. A.J. Centi, S.L. Booth, C.M. Gundberg, B. Nicklas cardiovascular disease prevention among young Brazilian and M.K. Shea. USDA at Tufts Univ., Yale Sch. of Med. and college students. K. Bousquet-Santos, D. Santos, A. Silva, P. Wake Forest Univ. Sch. of Med. Bastos, G. Oliveira and I. Martins. Univ. of Brasilia. D237 II 1067.14 Adiponectin levels in individuals with D225 II 1067.2 Korean pine nut oil attenuated hepatic type 2 diabetes on a high fiber or a low glycemic index diet. TG accumulation in high-fat diet-induced obese mice. S. Park, L.S.A. Augustin, S. Blanco Mejia, A. Mirrahimi, S. Mitchell, S. Shin, Y. Lim, J.H. Shin, J.K. Seong and S.N. Han. Seoul P. Connelly, C.W.C. Kendall and D.J.A. Jenkins. St. Michael’s Natl. Univ. Hosp., Toronto, Univ. of Toronto and Univ. of Saskatchewan. D226 I 1067.3 Vitamin E and vitamin C supplementation does not prevent glucose intolerance in obese-prone rats. M.J. 1068. OBESITY: PHYSICAL ACTIVITY Picklo. USDA, Grand Forks. D227 II 1067.4 Fatty liver accompanies an increase of Poster Lactobacillus acidophilus in the hind gut of C57/BL mice fed (Sponsored by: Obesity RIS) a high-fat diet. H. Zeng, J. Liu, M. Jackson, L. Yan and G. Combs, Jr. USDA, Grand Forks and Mayo Clin., Scottsdale, Tue. 7:30 am—Boston Convention & Exhibition Center, AZ. Exhibit Halls A-B D228 I 1067.5 Atypical antipsychotics attenuate Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) associations between linoleic acid and reduced markers of metabolic syndrome. S.J. Evans, A.R. Prossin, M.G. McInnis, D238 I 1068.1 Substituting dietary monounsaturated C.F. Burant and V.L. Ellingrod. Univ. of Michigan Col. of fat for saturated fat is associated with increased daily physical Pharm. activity and resting energy expenditure and with changes in D229 II 1067.6 Do dietary behaviors of adult preterms mood. C.L. Kien, J.Y. Bunn, C.L. Tompkins, J.A. Dumas, K.I. explain some of the elevated future risk of cardiovascular Crain, D.B. Ebenstein, T.R. Koves and D.M. Muoio. Univ. of disease? M. Sharafi, V.B. Duffy, R.J. Miller, S.B. Winchester Vermont Col. of Med., Colchester and Burlington and Duke T and M.C. Sullivan. Univ. of Connecticut, Women & Infants Univ. U Hosp., Providence and Univ. of Rhode Island. D239 II 1068.2 Effects of a dietary and Tai Chi E D230 I 1067.7 Non-alcoholic fatty liver disease in non- intervention on body composition in obese older women. J. diabetic subjects: independent relationship of dietary profile Bekke, J. Letendre, N. Beebe, F. Xu, I. Lofgren and M.J. and bright liver score with the severity of systolic heart function Delmonico. Univ. of Rhode Island. impairment. G.M. Trovato, D. Catalano, G.F. Martines, F. D240 I 1068.3 Feasibility of current physical activity Carcò, D. Coco, D. Brischetto, A. Abate and F.M. Trovato. recommendations for school age children. M. Perez-Rodriguez, Univ. of Catania and Polyclin.-VE, Catania, Italy. E. Gamez, J. Talavera, N. Vega, D. Barrera, F. Pfeffer, E. Tejero D231 II 1067.8 High rate of overweight and obesity in and G. Melendez. Mexican Hlth. Fndn., Tlalpan, Mexican Inst. post-combat military service members and veterans exposed of Social Security, Cuahtemoc and Natl. Inst. of Genomic Med., to blast and/or blunt head trauma. K.N. Starr, C.A. Smith Tlalpan. Hammond, S.H. Candice, L. Markley, R. Sisk, C. Brown and D241 II 1068.4 The relationship between body C.W. Bales. Duke Univ. Med. Ctr. and Durham VA Med. Ctr. roundness, exercise dose, and exercise type. Y.L. Maeda, M. D232 I 1067.9 Reduction of metabolic syndrome by a Tibbi, M.J. Scott and S. Islam. Montclair State Univ. lifestyle-modification program is accompanied by improvements D242 I 1068.5 Environmental barriers to children’s of aerobic fitness and plasma antioxidant markers.F. Moreto, summer outdoor play. J. Worobey, L. Lelah and R. Gaugler. R.M. Manda, K.C. Portero-McLellan, C.R. Correa and R.C. Rutgers Univ. Burini. Botucatu Sch. of Med., Brazil.
357 NUTRITION TUESDAY
D243 II 1068.6 Combined effects of objectively 1071. PHYSIOLOGY AND PATHOPHYSIOLOGY measured physical activity and serum 25-hydroxyvitamin D status on type 2 diabetes risk among U.S. adults. J.E. Choi Poster and B.E. Ainsworth. Arizona State Univ. D244 I 1068.7 Sedentary behavior and mortality in (Sponsored by: Obesity RIS) older women. R. Seguin, D. Buchner, J. Liu, M. Allison, T. Tue. 7:30 am—Boston Convention & Exhibition Center, Manini, J. Manson, C. Messina, M. Patel, L. Moreland and A. Exhibit Halls A-B LaCroix. Cornell Univ., Fred Hutchinson Cancer Res. Ctr., Univ. of Illinois, Champaign, UCSD, Univ. of Florida, Harvard Med. Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) Sch., Stony Brook Univ., Duke Univ. and Univ. of Pittsburgh. D251 I 1071.1 Permethrin, a pyrethroid insecticide, D245 II 1068.8 Decreasing physical activity is linked potentiates adipogenesis in 3T3-L1 adipocytes. J. Kim, Y. Park, with increased obesity in Henan Province, China. D. Zhang, K.S. Yoon, J.M. Clark and Y. Park. Univ. of Massachusetts S. Zhang, X. Zhan, F. Chao and S. Du. Inst. of Publ. Hlth., Amherst and Korea Univ. Henan Ctr. for Dis. Control and Prevent., China and Univ. of D252 II 1071.2 Metabolic status of adipocytes triggers North Carolina at Chapel Hill. rapid adjustments of systemic glucose tolerance. C. Kless and D246 I 1068.9 Factors associated with physical M. Klingenspor. Tech Univ. Munich, Freising. inactivity among women in Santos, Brazil. A.B. Trude, Y. Mui, J. D253 I 1071.3 Gender differences in hepatic lipogenic Giltensohn and P.A. Martins. Fed. Univ. of São Paulo, Brazil and inflammatory genes after 72 hours of high fat diet. C. Miller, and Johns Hopkins Bloomberg Sch. of Publ. Hlth. P.T. Cooney, S. Rayalam, L.M. Brown and C.A. Baile. Univ. of Georgia, Univ. of North Carolina at Greensboro and Sch. of 1069. OBESITY: ENERGY EXPENDITURE Pharm., Philadelphia Col. of Osteo. Med., Suwanee, GA. D254 II 1071.4 Organochlorine insecticides potentiate Poster adipogenesis in 3T3-L1 adipocytes. J. Kim, Y. Park, K.S. Yoon, J.M. Clark and Y. Park. Univ. of Massachusetts Amherst and (Sponsored by: Obesity RIS) Korea Univ. Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B 1072. POLYUNSATURATED FATTY ACIDS AND
Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) HEALTH
D247 I 1069.1 Comparison of dynamic model predicted Poster and actual weight gain during overfeeding: an energy balance analysis. Y. Begum, S. Cupidon, T. Aftab and M. Anazodo. (Sponsored by: Energy and Macronutrient Metabolism RIS) Montclair State Univ., NJ. Tue. 7:30 am—Boston Convention & Exhibition Center, D248 II 1069.2 Adaptive thermogenic response to over Exhibit Halls A-B and underfeeding occurs acutely. A. O’Connor, W. Luo, J. Galanko, C. Brouwer and A.G. Swick. Univ. of North Carolina Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) Nutr. Res. Inst. and Univ. of North Carolina at Charlotte, D255 I 1072.1 Effects of age, sex, body mass index Kannapolis and Univ. of North Carolina at Chapel Hill. and APOE genotype on cardiovascular biomarker response to an n-3 polyunsaturated fatty acid supplementation. E. Thifault, 1070. OBESITY: SOCIOECONOMICS H. Cormier, A. Bouchard-Mercier, I. Rudkowska, S. Lemieux, P. Couture and M-C. Vohl. Laval Univ., Canada. Poster D256 II 1072.2 Dietary fat source alters hepatic gene expression profile and determines the type of liver (Sponsored by: Obesity RIS) pathology in rats overfed via total enteral nutrition. M. Ronis, J. Tue. 7:30 am—Boston Convention & Exhibition Center, Baumgardner, J. Marecki, L. Henning, X. Wu, K. Shankar, M. Exhibit Halls A-B Cleves, H. Gomez-Acevedo and T. Badger. Univ. of Arkansas for Med. Sci. Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) D257 I 1072.3 Protective effects of different dietary D249 I 1070.1 Public beliefs about involvement of proportion of fish oil on hepatic injury in chronic ethanol-fed religious institutions with obesity. S. Stiles and J. Sobal. rats. S-C. Yang, H-C. Peng, Y-L. Chen, W-H. Liao and X-D. Cornell Univ. Wang. Sch. of Nutr. and Hlth. Sci., Taipei Med. Univ. and USDA D250 II 1070.2 Associations between socioeconomic at Tufts Univ. status and dietary patterns in the REGARDS study population. D258 II 1072.4 Tri-docosahexaenoic but not tri- K.P. Kell, S.E. Judd, J.M. Shikany and J.R. Fernandez. Univ. eicosapentaenoic acid-rich emulsions are neuroprotective after of Alabama at Birmingham Sch. of Publ. Hlth. and Sch. of Med. cerebral hypoxic-ischemic injury in mice. K. Mayurasakorn, V.S. Ten and R.J. Deckelbaum. Columbia Univ. Med. Ctr. D259 I 1072.5 Estrogen increases the conversion of a-linolenic acid to docosahexaenoic acid in ovariectomized mice. J.K. Mason, S. Kharotia, A.K.A. Wiggins, J. Chen and L.U. Thompson. Univ. of Toronto.
358 TUESDAY NUTRITION
D260 II 1072.6 Expressional regulation of the leptin by D273 I 1072.19 Supplementation of omega 3 fatty n-3 FA is related to the epigenetic modification of its promoter acids, vitamins and minerals has a moderating effect in the in diet induced obese mice. C. Fan, W. Shen, C. Wang, R. behavior of typically developing adolescent schoolchildren in Deckelbaum and K. Qi. Beijing Children’s Hosp., Capital Med. the U.K.: a double blind placebo controlled trial. J. Tammam, D. Univ. and Columbia Univ. Med. Ctr. Steinsaltz, D.W. Bester, T. Semb and J. Stein. Oxford Univ. D261 I 1072.7 Risk factors for age-related macular D274 II 1072.20 Metabolic effects of bedtime pistachio degeneration appear early in life. M.J. Buck, H.A. Durham, consumption for 6 weeks in overweight persons. A.D. A.R. Smither, B.G. Woods, E.L. Nickens, M.M. Lewis and Anderson, M.M. Anderson, J.L. Jacobson, M.R. Popko, J.R. C.J. Lammi-Keefe. LSU, Pennington Biomed. Res. Ctr. and Young, P.J. Limburg and T. Wilson. Winona State Univ. and LSU AgCtr. Mayo Clin. D262 II 1072.8 Plasma n-3/n-6 PUFAs interact D275 I 1072.21 Omega-3 fatty acid intake patterns with FADS2 genetic variations to affect blood cholesterol in obese Southern women. K. Heidal, T. Goad, J. Cox, R.C. concentrations in type 2 diabetes. M-C. Huang, P-C. Huang, Hickner and R.N. Cortright. Col. of Human Ecol. and Brody H-F. Chung and C-C. Hsu. Kaohsiung Med. Univ. and Natl. Sch. of Med., East Carolina Univ. Hlth. Res. Inst., Zhubnan, Taiwan. D263 I 1072.9 Polyphenol supplementation amelio- 1073. METABOLIC PHENOTYPING, METABOLOMICS rates PUFA benefits in metabolic and oxidative status in dogs. AND BIOMARKERS V.M. Leray, C. Talbot, K. Ouguerram, A-S. Martineau and P. Nguyen. Oniris, Vet Sch. Nantes and U1089,INSERM, Nantes. Poster D264 II 1072.10 Vegans report less mood disturbance than omnivores. B. Beezhold and J. Schiappa. Benedictine (Sponsored by: Energy and Macronutrient Metabolism RIS) Univ., IL. Tue. 7:30 am—Boston Convention & Exhibition Center, D265 I 1072.11 Effects of heated versus unheated Exhibit Halls A-B soybean oil in C57BL/6J mice. O. Middleton, N. Dingels and M. Penumetcha. Georgia State Univ. Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) D266 II 1072.12 Erythrocyte levels of omega-3 D276 I 1073.1 Contrast ultrasound imaging of the polyunsaturated fatty acids were negatively associated with aorta does not affect progression of atherosclerosis in ApoE- the risk of rheumatoid arthritis in Korean women. A. Lee and Y. /- mice. B.W. Smith, D.G. Simpson, S. Sarwate, R.J. Miller, Park. Hanyang Univ., South Korea. R.M. Abuhabsah, J.W. Erdman, Jr. and W.D. O’Brien, Jr. D267 I 1072.13 Bone mechanical competence in Univ. of Illinois at Urbana-Champaign. hypercholesterolemic rats fed MUFAn9 rich diets. E. Alsina, D277 II 1073.2 Effects of consuming oxidized vegetable C. Bozzini, E. Macri, F. Lifshitz, P. Rodriguez, P. Boyer and oils on tryptophan metabolism. L. Wang, D. Yao and C. Chen. S. Friedman. Sch. of Dent.. Univ. of Buenos Aires and Pediat. Univ. of Minnesota Twin Cities. Sunshine Acads. & Sansum Med. Res. Inst., Santa Barbara, D278 I 1073.3 2-Hydrazinoquinoline as a novel CA. derivatization agent for LC-MS-based metabolomic D268 II 1072.14 Low omega-3 fatty acid status in investigation of streptozotocin-elicited ketoacidosis. Y. Lu, D. residents of the Guatemalan Pacific Coastal Plain.R. Campos, Yao and C. Chen. Univ. of Minnesota, St.Ppaul. M.J. Soto-Méndez, E. Bailey, M. Detlefsen, K. Kraemer and D279 II 1073.4 Effect of an algal infusion on plasma N. Salem. CeSSIAM, Guatemala City, DSM Nutr. Products metabolomic profile in hypercholesterolemic hamsters.A. LLC, Columbia, MD, Cabcorp, Guatemala City and DSM Nutr. Geamanu, N. Saadat, A. Goja and S.V. Gupta. Wayne State Products Ltd., Kaiseraugst, Switzerland. Univ. D269 I 1072.15 Parenteral lipid minimization versus D280 I 1073.5 Investigation of metabolic adaptation composition for intestinal failure associated liver disease. J.K. in developing chicken embryo and post-hatch chicks by blood Josephson, P.W. Wales, P.N. Nation, P. Wizzard, D. Mager, metabolomics. Q. Hu, U. Agarwal and B.J. Bequette. Univ. of T C.J. Field, R.O. Ball, P.B. Pencharz and J.M. Turner. Univ. of Maryland College Park. Alberta and Univ. of Toronto. U D281 II 1073.6 Plasma amino acids as predictors for D270 II 1072.16 Phospholipid PUFA: a better indicator E outcome in patients at the intense care unit. B. Twelkmeyer, for assessing health risks. Y. Li, A.A. Friedman, Z. Yu, H. P.C. Rodas, E. Skog-Nejman, J. Wernerman and O. Tamez, J. Wenger, R. Thadhani and B.A. Watkins. Univ. of Rooyackers. Karolinska Univ. Hosp. Huddinge. Connecticut, Indiana Univ. Sch. of Med. and Massachusetts D282 I 1073.7 Plasma branch chain and aromatic Gen. Hosp. amino acid levels are associated with insulin resistance in D271 I 1072.17 Human milk fat globule proteinogenic nonalcoholic fatty liver disease. N.E. Sunny, R. Lomonaco, R. mRNA reveal existence of alternative transcripts. K.S.D. Petrocelli, U. Bashir, A. Egan and K. Cusi. Univ. of Florida. Kothapalli, J.S. Zou, S.S. Hyon, K.E. Ojukwu, G.L. Bugbee, D283 II 1073.8 A targeted lipidomic analysis of renal R. Alluri, H.K. Park, J. Zhang, R.R. Ran-Ressler and J.T. oxylipins in kidney disease reveals differences in the effects of Brenna. Cornell Univ. dietary flax compared to fish oil. J.G. Devassy, T. Yamaguchi, D272 II 1072.18 Baseline serum n-3 eicosapentaenoic N. Ibrahim, A. Ravandi and H.M. Aukema. Univ. of Manitoba, acid concentration is associated with subsequent mood Canadian Ctr. for Agri-Food Res. in Hlth. and Med. and St. disturbance during the acute stress of military survival school Boniface Gen. Hosp. Res. Ctr., Winnipeg. training. E.K. Farina, K. Grohmann, J.C. Biedenkapp, J.P. D284 I 1073.9 Calorie intake and blood lipidomics. B. McClung and H.R. Lieberman. U.S. Army Res. Inst. of Envrn. Kristal, V.S. Hubbard, P. Starke-Reed, S.S. Bird, V.R. Marur, Med., Natick, MA, Oak Ridge Inst. for Sci. and Educ., Belcamp, M. Sniatynski and D. Sheldon. Brigham and Women’s Hosp, MD and U.S. Army John F. Kennedy Spec. Warfare Ctr., Fort Harvard Med. Sch. and NIDDK, NIH. Bragg, NC.
359 NUTRITION TUESDAY
D285 II 1073.10 Perinatal bisphenol A exposure D295 I 1074.5 Effects of fructose on uric acid promotes hyperactivity with corresponding hormonal metabolism. F. Theytaz, L. Egli, Y. Cordero Rodriguez, V. responses. O.S. Anderson, K.E. Peterson, B.N. Sanchez, Z. Campos, P. Schneiter and L. Tappy. Univ. of Lausanne. Zhang, P. Mancuso and D.C. Dolinoy. Univ. of Michigan. D296 II 1074.6 Reduced glycemic response to starch D286 I 1073.11 Impact of parenteral lipid emulsions feeding of Mgam null mice is buffered by increased endogenous on the metabolomic phenotype in preterm TPN-fed piglets. gluconeogenesis. A.H-M. Lin, M. Diaz-Sotomayor, R. M.A. Kulkarni, H. Vlaardingerbroek, B. Stoll, O. Ilkayeva, C. Quezada-Calvillo, S.E. Avery, S.K. Chacko, L-k. Yan, Z-h. Newgard, O. Olutoye, J.B. Van Goudoever and D. Burrin. Ao, B.R. Hamaker and B.L. Nichols. Purdue Univ. and USDA, Baylor Col. of Med., Erasmus MC-Sophia Children’s Hosp., Baylor Col. of Med. Rotterdam, Duke Univ. Med. Ctr. and VU Univ. Med. Ctr., D297 I 1074.7 A randomized, crossover comparison of Amsterdam. the effects of high fructose corn syrup versus sucrose intake on D287 II 1073.12 Targeted disruption of the nucleosomal basic physiologic measures. E.M. Mouch, A.M. Walz, L. Tomaj binding protein HMGN5 results in altered glutathione and J.W. Carbone. Eastern Michigan Univ. Sch. of Hlth. Sci. metabolism and mild hepatic dysfunction. E.D. Ciappio, M. D298 II 1074.8 Fructose intake and circulating Rochman, M. Horsch, J. Beckers, K.W. Krausz, J.A. Bonzo, triglycerides: an examination of the roles of APOC 3 and F.J. Gonzalez and M. Bustin. NCI, NIHand German Res. Ctr. FOXO1. E.S. Campbell and T.W. Castonguay. Univ. of for Envrn. Hlth., Neuherberg. Maryland College Park. D288 I 1073.13 Metabolomics profiling predicts SORT1 D299 I 1074.9 Dairy snack reduces glycemia in normal LDL-cholesterol locus in a fit, young adult population.L. weight children. B. Gheller, M. McCormick, A. Li, Y. Anini, N. Kirtiadi, E. Gnatiuk, A. Karlos, K. Connors, H.J. Vogel, J. Bellissimo, J. Hamilton, G.H. Anderson and B.L. Luhovyy. Shearer and D.S. Hittel. Univ. of Calgary, Canada. Mount Saint Vincent Univ. and Dalhousie Univ., Halifax, D289 II 1073.14 Association of lead exposure and Ryerson Univ., Toronto and Univ. of Toronto. untargeted metabolomics with BMI and hormones in D300 II 1074.10 Elevated gluconeogenesis in aging and adolescence. K.E. Peterson, D. Dolinoy, C. Burant, J. Lee, lung cancer is related to inflammation and blunted insulin- B. Sanchez, Z. Zhang, T.C. Yang, J. Goodrich, A. Ettinger, induced protein anabolism. J. MacAdams, A. Winter, J.A. J. Meeker, H. Hu, M. Solano, N. Wang and M.M. Tellez-Rojo. Morais, S.C. Burgess and S. Chevalier. McGill Univ. and Univ. Univ. of Michigan Sch. of Publ. Hlth., Univ. of Michigan Med. of Texas Southwestern Med. Ctr. Sch., Yale Sch. of Publ. Hlth., Univ. of Toronto, Natl. Inst. of Publ. D301 I 1074.11 Effect of cinnamon on blood glucose, Hlth., Cuernavaca and Univ. of Michigan. satiety and caloric intake in middle-aged obese adults. J.C. D290 I 1073.15 Metabolomic profiling of the small for Chezem , S. Tickle, N. Fernandes and J.H. Bolin. Ball State gestational age piglet. C.M. Getty, A.A. Baratta and R.N. Univ. Dilger. Univ. of Illinois, Urbana. D302 II 1074.12 Grain sorghum reduces plasma glucose and insulin levels in healthy men. X. Gu, N. Poquette and S-O. 1074. CARBOHYDRATE METABOLISM Lee. Univ. of Arkansas. D303 I 1074.13 Enzyme-synthesized highly branched Poster maltodextrins have slow glucogenesis at the mucosal a-glucosidase level and are slowly digestible in vivo. B-H. Lee, (Sponsored by: Energy and Macronutrient Metabolism RIS) B.L. Nichols and B.R. Hamaker. Purdue Univeristy and Baylor
Tue. 7:30 am—Boston Convention & Exhibition Center, Col. of Med. Exhibit Halls A-B D304 II 1074.14 In vitro fermentation of various pectin substrates by human fecal microbiota. B. Min, O-k. Koo, N. Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) Jarvis, P. Crandall, S. Ricke and S-o. Lee. Univ. of Arkansas. D291 I 1074.1 Acute human consumption of crystalline short-chain amylose. Y-C. Shi, L.R. Brewer, C. Weber, L. Cai 1075. PROTEIN INTAKE AND HEALTH IMPLICATIONS and M.D. Haub. Kansas State Univ. D292 II 1074.2 A standardized method for preparation Poster of potatoes and analysis of their resistant starch content: (Sponsored by: Energy and Macronutrient Metabolism RIS) variation by cooking method and service temperature. M.I. Jackson, L.A. Idso, G.F. Combs, K. Beals and S.K. Raatz. Tue. 7:30 am—Boston Convention & Exhibition Center, USDA, Grand Forks, Univ. of Utah and Univ. of Minnesota, St. Exhibit Halls A-B Paul. Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) D293 I 1074.3 Lactating mouse mammary gland expresses secreted Mgam which enables unweaned suckling D305 I 1075.1 Casein and gluten-derived opiate pup starch digestion. B.L. Nichols, M. Diaz-Sotomayor, S.E. peptides affect cysteine uptake and redox status. J.J. Shah, M. Avery, D.L. Hadsell, L. Yan, B.R. Hamaker and R. Quezada- Trivedi, N. Hodgson and R. Deth. Northeastern Univ. Calvillo. Baylor Col. of Med., Purdue Univ. and Autonomous D306 II 1075.2 Plant and animal protein intakes are Univ. of San Luis Potosi, Mexico. differently associated with nutrient adequacy in French adults. D294 II 1074.4 Chronic distal digesting of starch reduces E.O. Verger, G.M. Camilleri, J-F. Huneau, F. Carpentier, C. subsequent starch digestion through a post-translational Dubuisson and F. Mariotti. AgroParisTech, Danone Res., mechanism which reduces mucosal disaccharidase activities. Palaiseau and ANSES, Maisons-Alfort, France. L. Yan, S.E. Avery, F.A. Vohra, S.K. Chacko, B.L. Nichols and D307 I 1075.3 Meal consisting of egg white protein B.R. Hamaker. Purdue Univ. and Baylor Col. of Med. yields higher satiety than an isocaloric wheat gluten protein meal. K. Du, S. Adams and J.L. Beverly. Univ. of Illinois at Urbana-Champaign.
360 TUESDAY NUTRITION
D308 II 1075.4 Effect of leucine supplementation on D319 II 1076.2 Effect of Eurycoma longifolia on stress lean body mass during prolonged hypoxic exposure for 13-day hormones and psychological mood state in moderately trek to Everest Base Camp: a double-blind randomized study. stressed subjects. S. Talbott, J. Talbott, A. George and M. D.C. Gershenoff, S.L. Wing-Gaia, M.J. Drummond, P.F. Gaia Pugh. SupplementWatch, Draper, UT, Biotropics Malaysia, and E.W. Askew. Univ. of Utah. Kuala Lumpur and MonaVie, South Jordan, UT. D309 I 1075.5 Higher protein preterm formula D320 I 1076.3 Effect of magnolia/phellodendron on increases weight gain. S. Simpson, T. Kennedy and R. cortisol and mood state in moderately stressed subjects. S. Larzelere. Oklahoma State Univ. Talbott, J. Talbott and M. Pugh. SupplementWatch, Draper, D310 II 1075.6 Dietary protein requirement of 65-75 UT and MonaVie, South Jordan, UT. year old females using indicator amino acid oxidation technique. D321 II 1076.4 Energy drink use in military populations: M. Rafii, G. Courtney-Martin, K. Chapman, J. Owens, R. an exploratory analysis. L.F. Delahanty, E. Jones, S. Attipoe, Elango, W.W. Campbell, R.O. Ball and P.B. Pencharz. The P. Deuster, D. Jones and M. Stephens. Uniform Svc. Univ. of Hosp. for Sick Children, Toronto, Univ. of British Colombia, Hlth. Sci. Purdue Univ. and Univ. of Alberta. D322 I 1076.5 HMB attenuates a loss of myofiber D311 I 1075.7 Effects of whey protein supplementation cross-sectional area during prolonged exercise with calorie on dietary compensation and muscle energetics in elderly restriction by enhancing regenerative capacity. B-S. Park, P.C. adults. K.L. Clark, K.A. Sands, S.P. McKenzie, J.M. Haddad, Henning, A.V. Khamoui, E. Jo, S-R. Lee, M.C. Zourdos, D-H. S. Rietdyk and W.W. Campbell. Purdue Univ. and Indiana Kim, M-C. Yeh and J-S. Kim. Florida State Univ., U.S. Army Univ.-Purdue Univ. Indianapolis. Res. Inst. of Envrn. Med., Natick, MA, Univ. of Memphis and D312 II 1075.8 No difference in protein leverage Florida Atlantic Univ. affecting energy intake between soy and whey protein. E. D323 II 1076.6 Comparison of watermelon and Martens, S. Lemmens and M. Westerterp-Plantenga. carbohydrate beverage on exercise-induced oxidative stress, Maastricht Univ., Netherlands. inflammation, and immune dysfunction, and augmentation D313 I 1075.9 The impact of a protein-rich breakfast index. R.A. Shanely, D.C. Nieman, A.M. Knab, P. Perkins- on food cravings and reward in overweight/obese ‘breakfast Veazie, D. Henson, L. Cialdella-Kam, W. Sha and M.P. skipping’ adolescent girls. L.C. Ortinau, H.A. Hoertel, S.M. Meaney. Appalachian State Univ., North Carolina State Univ. Douglas and H.J. Leidy. Univ. of Missouri-Columbia. and Univ. of North Carolina at Charlotte, Kannapolis. D314 II 1075.10 Rice bran protein concentrate can D324 I 1076.7 A randomized double blind placebo reduce fat accumulation in rats fed high-fat diet. J. Yu and O. controlled evaluation of MSM for exercise-induced discomfort/ Lee. Yongin Univ., South Korea. pain. D. Kalman, S. Feldman, A. Samson and D. Krieger. D315 I 1075.11 Dietary protein intake, energy deficit, Miami Res. Assocs. and nitrogen balance in normal-weight adults: a randomized D325 II 1076.8 Effects of a novel dietary supplement on controlled trial. L.M. Margolis, J.J. Cao, L.D. Whigham, J.P. physical and mental function in middle-aged adults: a double- McClung, G.F. Combs, A.J. Young and S.M. Pasiakos. U.S. blind, randomized, placebo-controlled trial. S.M. Wood, S. Army Res. Inst. of Envrn. Med., Natick, MA and USDA, Grand Poole, M. Bartlett, A. Mastaloudis and D. Burke. Nu Skin Forks. Enterprises, Provo, UT. D316 II 1075.12 Dietary protein requirement of 65- 75 year old adult males using indicator amino acid oxidation 1077. B VITAMINS AND ONE-CARBON METABOLISM technique. G. Courtney-Martin, M. Rafii, K. Chapman, R. Elango, W.W. Campbell, R.O. Ball and P.B. Pencharz. The Poster Hosp. for Sick Children, Torontom British Columbia Children’s Hosp., Purdue Univ. and Univ. of Alberta. (Sponsored by: Vitamins and Minerals RIS)
D317 I 1075.13 Current intake of animal and vegetable Tue. 7:30 am—Boston Convention & Exhibition Center, protein in the U.S.: What We Eat in America/National Health Exhibit Halls A-B T and Nutrition Examination Survey, 2007-2010. V.L. Fulgoni III, D.R. Keast, C.E. O’Neil and T.A. Nicklas. Nutr. Impact LLC, Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) U E Battle Creek, MI, Okemos, MI, LSU AgCtr. and USDA, Baylor D326 I 1077.1 A comparison of American and Col. of Med. Canadian RBC folate concentrations. C.K. Colapinto, M.S. Tremblay, S. Aufreiter, T. Bushnik, C.M. Pfeiffer and D.L. 1076. SPORTS NUTRITION: DIETARY SUPPLEMENTS O’Connor. Children’s Hosp. of Eastern Ontario Res. Inst., The AND HUMAN PERFORMANCE Hosp. for Sick Children, Toronto Stats. Canada, Ottawa and Ctrs. for Dis. Control and Prevent. Poster D327 II 1077.2 Folate in human skin: its correlation with serum levels, and the unusual abundance in the epidermis Tue. 7:30 am—Boston Convention & Exhibition Center, of 5-methyl-tetrahydrofolate. L.Z. Hasoun, S.W. Bailey, K.K. Exhibit Halls A-B Outlaw and J.E. Ayling. Univ. of South Alabama and Mobile Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) Infirmary. D328 I 1077.3 A comprehensive list of D318 I 1076.1 The short-term effects of black pepper sociodemographic, dietary and lifestyle factors has limited (Piper nigrum) and rosemary (Rosmarinus officinalis) on predictive power in determining RBC folate concentrations sustained attention and energy and fatigue mood states in maximally protective against neural tube defects. B. Hartman, young adults with low energy. J.B. Lindheimer, B.D. Loy and A.J. Hanley, S. Aufreiter, C.K. Colapinto, M.S. Tremblay P.J. O’Connor. Univ. of Georgia. and D.L. O’Connor. Univ. of Toronto and Children’s Hosp. of Eastern Ontario, Ottawa.
361 NUTRITION TUESDAY
D329 II 1077.4 Comparison study between RBC D341 II 1077.16 Relationship between leukocyte global folate measured by microbiologic assay and Immulite 2000 DNA methylation and RBC folate in the Women’s Health immunoassay. S. Aufreiter, C.K. Colapinto, M.S. Tremblay, Initiative Observational Study. S. Bae, M.A. Caudill, L.B. Bailey, T. Bushnik, C.M. Pfeiffer and D.L. O’Connor. The Hosp. for O. Malysheva, J.W. Miller, E.C. Brown, M.L. Neuhouser, D. Sick Children, Toronto, Children’s Hosp. of Eastern Ontario, Maneval, T-Y.D. Cheng, L. Hou, S.A.A. Beresford, X. Song, Ottawa, Statistics Canada, Ottawa and Ctrs. for Dis. Control Y. Zheng, K. Buck and C.M. Ulrich. Cornell Univ., Univ. of and Prevent. Georgia, Rutgers Univ., Fred Hutchinson Cancer Res. Ctr., D330 I 1077.5 Perturbed 1-carbon metabolism alters Univ. of Florida, Northwestern Univ., Chicago and German bile acid pools and insulin signaling. K.D. Corbin, S. Mei, W. Cancer Res. Ctr., Heidelberg. Cao and S.H. Zeisel. Univ. of North Carolina at Chapel Hill, D342 I 1077.17 Low-dose methotrexate inhibits Kannapolis and Gillings Sch. of Global Publ. Hlth., Chapel Hill. methionine S-adenosyltransferase in vitro and in vivo. Y-C. D331 II 1077.6 Dietary intake and major food sources of Wang and E-P. Chiang. Natl. Chung Hsing Univ., Taiwan. vitamin B6 in Korean adults. Y-N. Kim and Y-O. Cho. Duksung D343 II 1077.18 Detectable levels of unmetabolized folic Women’s Univ., South Korea. acid in Canadian pregnant women. L. Plumptre, S. Masih, A. D332 I 1077.7 Choline modulates soluble-endoglin Ly, S. Aufreiter, R. Croxford, A.Y. Lausman, H. Berger, D.L. and vascular endothelial growth factor in cultured human O’Connor and Y-I. Kim. Univ. of Toronto, St. Michael’s Hosp. placental trophoblasts. B.Y. Andrew, X. Jiang, S. Jones, M.A. and The Hosp. for Sick Children, Toronto. Caudill and P.M. Brannon. Cornell Univ. D344 I 1077.19 Dietary vitamin B6 intake modulates D333 II 1077.8 Folate deficiency acceleratescolonic inflammation in the IL-10-/- model of inflammatory bowel Alzheimer’s disease related pathology in APP/PS1 mice. disease. J. Selhub, A. Byun, Z. Liu, J.B. Mason, R.T. Broson N. Crivello, T. Spires-Jones, B. Shukitt-Hale, A. Carey, and J.W. Crott. USDA at Tufts Univ., Univ. of Massachusetts A. Roe, D. Smith, J. Krzysztof Blusztajn, B. Hyman and I. Amherst and Harvard Med. Sch. Rosenberg. USDA at Tufts Univ., Massachusetts Gen. Hosp./ D345 II 1077.20 B-vitamins influence arsenic metabolism Harvard Med. Sch., Charlestown and Boston Univ. Sch. of Med. in Mexico. M.A. Mendez, R. Vavolizza, M.C. Gonzalez- D334 I 1077.9 Influence of lactation and choline Horta, J. Saunders, D. Gutiérrez-Torres, M.L. Ballinas intake on one-carbon biomarkers in women. C. Davenport, K. Casarrubias, B.E. Sánchez-Ramírez, M.C. Ishida, L.M. Del Shields, J. Yan, X. Jiang, O. Malysheva, M. Caudill, S. Stabler Razo, G. García-Vargas, Z. Drobná, J. Buse, D. Loomis and and R. Allen. Cornell Univ. and Univ. of Colorado Denver. M. Styblo. Univ. of North Carolina at Chapel Hill, Autonomous D335 II 1077.10 Response of vitamin B12 status to a Univ. of Chihuahua, Mexico, Univ. Juárez del Estado de controlled B12 intake in nonpregnant, pregnant, and lactating Durango, Mexico and IARC, Lyon, France. women. S. Bae, A.A. West, J. Yan, X. Jiang, C.A. Perry and D346 I 1077.21 Anthranilic acid and 3-hydroxyanthranilic M.A. Caudill. Cornell Univ. acid, but not kynurenic acid, are associated with plasma D336 I 1077.11 Fortifying whole wheat flour with folic pyridoxal-5 phosphate levels. C.D. Reginaldo, J. Selhub, L. acid does not change the prevalence of folate inadequacy nor Paul, P. Jacques, T. Wang and R. Gerszten. Friedman Sch. of the percentage of Canadians with intakes above the tolerable Nutr. Sci. and Policy and USDA at Tufts Univ. and Massachusetts upper intake level. Y-M. Chan, A. MacFarlane and D.L. Gen. Hosp., Harvard Med. Sch. O’Connor. Univ. of Toronto and Hlth. Canada, Ottawa. D347 II 1077.22 Methylmalonic acid concentration in D337 II 1077.12 Genetic C677T polymorphisms dried blood spots – validation of a novel method for vitamin of methylenetetrahydrofolate reductase and one-carbon B12 status assessment. T.H. Schroder, T.A.W. Quay and Y. metabolites as prognostic predictors for survival outcome of Lamers. Univ. of British Columbia. patients with hepatocellular carcinoma. C.S. Kuo, C-Y. Hwung, D348 I 1077.23 Effects of vitamin B6 on one-carbon S-D. Kuo, C-P. Cheng, C-H. Chen, C-L. Lu and R-F. Huang. metabolism in oral contraceptive users. L. Rios-Avila, M. Fu Jen Univ., New Taipei City, Chi-Mei Med. Ctr., Tainan and Ralat, B. Coats, P.W. Stacpoole and J.F. Gregory. Univ. of Natl. Taiwan Univ. Hosp. and Col. of Med. Florida Col. of Med. D338 I 1077.13 Uracil accumulation induced by folate D349 II 1077.24 The effects of folate, choline and betaine depletion is dependent on uracil DNA glycosylase activity. H. on transmethylation in a methionine-restricted piglet. J.L. Ma, Y. Wu, K. Simon, A. Ahmed and D.C. Cabelof. Wayne Robinson, L.E. McBreairty, J.A. Brunton and R.F. Bertolo. State Univ. Mem. Univ. of Newfoundland, Canada. D339 II 1077.14 Pregnancy increases the use of choline- D350 I 1077.25 Folic acid supplementation for 12 weeks derived methyl groups for phosphatidylcholine production modifies gene expression in leukocytes in men with low folate through the PEMT pathway with subsequent selective transfer status. L. Paul, C. Razzari, F. Sampietro, G. Fontana, I. Fermo, of PEMT-PC to the fetus. J. Yan, A.A. West, X. Jiang, C.A. C. Reginaldo, M. Cattaneo, A. D’Angelo, P.F. Jacques and J. Perry, O.V. Malysheva and M.A. Caudill. Cornell Univ. and Selhub. USDA at Tufts Univ., Hosp. San Paolo, Univ. of Milan Shepherd Univ., WV. and Sci. Inst. San Raffaele, Milan. D340 I 1077.15 The effect of fruits and vegetables in the D351 II 1077.26 Cellular pyridoxal phosphate elevated plasma homocysteine: experience of using a quantile concentration influences amino acid profiles and presence regression approach. J. Steluti, E. Verly, Jr., R.M. Fisberg and of hydrogen sulfide biomarkers in cultured HepG2 cells.B.N. D.M.L. Marchioni. Sch. of Publ. Hlth., Univ. of São Paulo and DeRatt, M. Ralat, O. Kabil, R. Banerjee and J.F. Gregory. Inst. of Soc. Med., Rio de Janeiro State Univ. Univ. of Florida and Univ. of Michigan Med. Sch. D352 I 1077.27 Paternal folate deficiency influences hepatic DNA methylation, IGF-1, IGF-2 and IGF-1R expression in the rat pup. K.K.R. Mejos, E.M. Lim, H.W. Kim and N. Chang. Ewha Womans Univ., South Korea.
362 TUESDAY NUTRITION
1078. CARDIOVASCULAR EFFECTS OF DIETARY D363 I 1078.11 Barley beta-glucan consumption BIOACTIVE COMPONENTS decreases serum cholesterol level and increases 7 alpha- hydroxy-4-cholesten-3-one level in hypercholesterolemic Poster adults. Y. Wang, S.E. Harding, S.M. Tosh, P.J. Jones and N.P. Ames. Univ. of Manitoba, Cereal Res. Ctr., Winnipeg, King’s (Sponsored by: Dietary Bioactive Components RIS) Col. London, Guelph Food Res. Ctr. and Richardson Ctr. for Tue. 7:30 am—Boston Convention & Exhibition Center, Funct. Foods and Nutraceuts., Winnipeg. Exhibit Halls A-B D364 II 1078.12 Comparison of hypolipidemic effects of three berries in diet-induced obese C57BL6J mice. B. Kim, Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) S.G. Lee, C.S. Ku, Y. Park, Y. Yang, T.X. Pham, C. Wegner, S.I. D353 I 1078.1 Effects of low-fat dairy intake on Koo, O.K. Chun and J. Lee. Univ. of Connecticut. blood pressure and endothelial function in subjects with D365 I 1078.13 Effects of polyphenolic-rich dark pre-hypertension or stage I hypertension. K. Maki, T. Rains, chocolate/cocoa and almonds on established and emerging A. Schild, M. Dicklin, A. Lawless, K. Kelley and K. Park. cardiovascular risk factors: study design. C.E. Berryman, Biofortis Clin. Res., Addison, IL and Dairy Res. Inst./Natl. Dairy S.G. West, C-Y.O. Chen, J.B. Blumberg, J.A. Fleming, A.G. Council, Rosemont, IL. Preston, D.L. Miller and P.M. Kris-Etherton. Penn State, D354 II 1078.2 Effects of walnuts on vascular function USDA at Tufts Univ. and The Hershey Co. and platelet reactivity in postmenopausal women with D366 II 1078.14 Consuming 12 eggs per week for 1 hypercholesterolemia. S.J. Yim, D. Djurica, R.R. Holt, C.L. year does not alter serum lipids, lipoprotein cholesterol, or Keen and R.M. Hackman. Univ. of California, Davis. C-reactive protein in older adults. T.A. Wilson, H. Aljohi, E. D355 I 1078.3 Manganese supplementation reduces Kotyla and M.D. Nelson. Univ. of Massachusetts Lowell. monocyte adhesion to endothelial cells by reducing ROS and D367 I 1078.15 Effect of vitamin D on ROS, ICAM-1 downregulating ICAM-1 independently of MnSOD. E. Burlet and monocyte adhesion in human umbilical vein endothelial and S.K. Jain. LSU Hlth.- Shreveport. cells treated with high glucose and acetoacetate. P. Kanikarla- D356 II 1078.4 Assessment of folate, vitamin B6 and Marie and S.K. Jain. LSU Hlth. Sci. Ctr., Shreveport. vitamin B12 status among newly diagnosed Omani cardiac D368 II 1078.16 Effects of milk and carbonated beverage patients. M.I. Waly, A. Ali, Y.M. Al-Farsi, A. Ouhtit, A. Al- consumption on ambulatory blood pressure and cardiovascular Nassri and M. Arafa. Sultan Qaboos Univ., Oman, Alexandria responses to stress: a pilot study. S.A. Kynast-Gales, E.C. Univ., Egypt and King Saud Univ., Saudi Arabia. Johnson and L.K. Massey. Washington State Univ. D357 I 1078.5 Low-fat dairy intake improves endothelial function in subjects with pre-hypertension or stage 1079. DIETARY BIOACTIVE COMPONENTS OF I hypertension and impaired endothelial dysfunction. K. Maki, MEDICINAL, FUNCTIONAL AND WHOLE FOODS T. Rains, A. Schild, M. Dicklin, A. Lawless, K. Kelley and K. (INCLUDING PROBIOTICS AND FERMENTED Park. Biofortis Clin. Res., Addison, IL and Natl. Dairy Council, FOODS) Rosemont, IL. D358 II 1078.6 Wild blueberry-enriched diet affects a1- Poster adrenergic induced vasoconstrictor response in the aorta of obese Zucker rats. S. Vendrame, A.S. Kristo, A. Daugherty, (Sponsored by: Dietary Bioactive Components RIS)
D.A. Schuschke and D. Klimis-Zacas. Univ. of Maine and Tue. 7:30 am—Boston Convention & Exhibition Center, Univ. of Louisville Sch. of Med. Exhibit Halls A-B D359 I 1078.7 Physiological responses to caffeine are moderated by sex and pubertal phase. A.M. Ziegler, A. Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) Graczyk, A. Bendlin, K. Vattana, T. Sion, S. O’Leary and J.L. D369 I 1079.1 Pooled analysis of impact of Lycium Temple. Univ. at Buffalo. barbarum fruit (goji) intake on central adiposity, sleep quality T D360 II 1078.8 Regulation of genes involved intestinal and general well-being: randomized, double-blind, placebo- U cholesterol metabolism by polyphenol-rich black currant controlled human clinical studies. H. Amagase, C-H. Hsu and E extract in Caco-2 cells. B. Kim, A. Perkins and J. Lee. Univ. of D.M. Nance. FreeLife Intl., Phoenix, Univ. of Arizona Col. of Connecticut. Publ. Hlth. and Univ. of California Irvine, Orange. D361 I 1078.9 Effect of rosemary supplementation D370 II 1079.2 Sorghum extracts reduced hepatic on oxidative stress after myocardial infarction in rats. B.P.M. cholesterol biosynthesis in mice fed high cholesterol diet. S.H. Rafacho, P.P. dos Santos, A.F. Gonçalves, R. Candido, Kim and Y. Park. Hanyang Univ., South Korea. A.A.H. Fernandes, P.A. Schmidt, L.A.M. Zornoff, Á.O. D371 I 1079.3 Effects of dietary fiber on body Campana, M.F. Minicucci and S.A.R. Paiva. São Paulo State mass index: a systematic review of cross-sectional studies, Univ., Bauru and Botucatu. prospective cohort studies and randomized controlled trials. R. D362 II 1078.10 Effect of a flavonoid-rich cacao extract Korczak and J.L. Slavin. Univ. of Minnesota, St. Paul. on vascular reactivity in a mouse model. K.G. Castillo- D372 II 1079.4 The efficacy of some common Hernández, M.C. Castillo-Hernández, G. Guevara-Balcázar vegetables in ameliorating the impact of cement dust selected and R.M. Coral-Vázquez. Grad. Sch. of Med., Natl Polytech enzymes in wild and laboratory rats. J.E. Okpuzor and Y. Inst., Mexico City. Tajudeen. Univ. of Lagos, Nigeria.
363 NUTRITION TUESDAY
D373 I 1079.5 Differential capability of Korean soybean D388 II 1079.20 L. reuteri NCIMB 30242: a probiotic with varieties to biosynthesize glyceollins. J-S. Kim, I.S. Park, H.J. benefits. M.L. Jones, C.J. Martoni and S. Prakash. McGill Kim, J.Y. Seo, S.S. Kim, B.R. Kim, A. Zakharova and H.R. Univ. and Micropharma, Montreal. Kang. Sch. of Applied Biosci., Kyungpook Natl. Univ., South D389 I 1079.21 Bioactive compounds and antioxidant Korea. property of Korean traditional tea. H-R. Yang, Y-J. Yi, J-S. Park, D374 II 1079.6 The p53-dependent elevation of human H-B. Jo, J-H. Kim and Y-Z. Chae. Seoul Metro. Govt. Res. Inst. colon cancer stem cell apoptosis by Java plum anthocyanins. of Publ. Hlth. and Envrn. V.R. Charepalli, L. Reddivari and J. Vanamala. Colorado D390 II 1079.22 Effects of the sea tangle-added patty State Univ. on postprandial blood glucose and lipid profiles in borderline- D375 I 1079.7 Antidiabetic effects and antioxidant hyperlipidemic adults. H-S. Lim and H-H. Kim. Chonnam Natl. capacity of polyphenol-enhanced Rutgers scarlet lettuce. D.M. Univ., South Korea. Cheng, N. Pogrebnyak, A. Poulev, P. Kuhn, C.G. Krueger, D391 I 1079.23 Analysis of coenzyme Q10 in marine oil C. Waterman and I. Raskin. Rutgers Univ. and Complete supplements. C. Scholl, J. Dever and D. Barnes. Standard Phytochem. Solutions LLC, Cambridge, WI. Process Inc., Palmyra, WI. D376 II 1079.8 Anti-stress effect of enzyme-treated D392 II 1079.24 Sweet potato cultivar flesh color and asparagus extract (ETAS). S. Kudo, A. Sato, T. Ito, K. Homma compositional effects on glycemic index. J.C. Allen, W. Sun and H. Nishioka. Amino Up Chem. Co. Ltd., Sapporo. and V.D. Truong. North Carolina State Univ. and USDA, D377 I 1079.9 Wheat bran for colon cancer prevention: Raleigh. phytochemicals versus fiber. S. Sang, Y. Zhu and D.N. Soroka. D393 I 1079.25 Identification of resveratrol-3-b- North Carolina A&T State Univ. glucoside in Clifornia almond varieties. L. Xie and B. Bolling. D378 II 1079.10 Hypocholesterolemic effect of Univ. of Connecticut. hexacosanol in HepG2 cells and C57BL6 mice. J.H. Lee, Y. D394 II 1079.26 Changes in the metagenome and Kim, W-D. Seo and S-J. Lee. Col. of Life Sci. and Biotechnol, plasma lipids of hamsters fed high fat diets containing Korea Univ. and Natl. Inst. of Crop Sci., Miryang, South Korea. Chardonnay grape seed flour. H. Kim, T. Arvik, R. Lipson, D379 I 1079.11 Baked purple potato extracts, containing G.E. Bartley, D-H. Kim, K. Seo and W. Yokoyama. Univ. of anthocyanins, elevate apoptosis in colon cancer stem cells via California, Davis, Sonomaceuts., Santa Rosa, CA, USDA, p53 independent pathways. J. Vanamala, V. Charepalli and L. Albany, CA and Konkuk Univ., South Korea. Reddivari. Colorado State Univ. D395 I 1079.27 Fatty acid and phytosterol profiles of D380 II 1079.12 Health and functional characteristics of commercial saw palmetto supplements. K. Penugonda and indigenous food in the Korean longevity belt. M.S. Lee and K-H. B.L. Lindshield. Kansas State Univ. Moon. Hannam Univ. and Sunchang Inst. of Hlth. & Longevity, D396 II 1079.28 Fucosterol, a liver X receptors agonist, South Korea. stimulates RCT and regulates the expression of key genes in D381 I 1079.13 Changes in RAPD molecular marker cholesterol homeostasis in vitro. H. Minh Hien and S-J. Lee. polymorphism during Cordyceps sinensis maturation. L. Gao, Col. of Life Sci. and Biotechnol., Korea Univ. Y-S. Yao, Z. Wu and J-S. Zhu. Pharmanex Beijing Pharmacol. D397 I 1079.29 Seanol® and its major compound, Ctr., NS Ctr. for Anti-Aging Res., Provo, UT and Hong Kong dieckol suppress lipid accumulation during adipogenesis Polytech Univ. through inhibition of mitotic clonal expansion and cell cycle D382 II 1079.14 Standardized chungkookjang, short- arrest. H-S. Choi, H-J. Jeon, O-H. Lee and B-Y. Lee. CHA term fermented soybeans with Bacillus lichemiformis, improves Univ. and Kangwon Natl. Univ., South Korea. cognitive function and insulin resistance in b-amyloid-infused D398 II 1079.30 Effects of phytosterols and fatty acids diabetic rats. S. Park, S. Kang, H.J. Kim, D.Y. Kwon and J. from lotus (Nelumbo nucifera) seed on differentiation of human Daily. Hoseo Univ. and Korean Food Res. Insts., South Korea preadipocytes into adipocytes. S.H. Kim, X. Zhao, J. Shen and and Daily Manufacturing Inc., Rockwell, NC. K.J. Chang. Konkuk Univ. and Inha Univ., South Korea. D383 I 1079.15 Evaluation of long-chain n3 fatty acid D399 I 1079.31 A solute carrier protein, the mammalian content in diploid and triploid rainbow trout. M.J. Picklo, S.K. flavonoid transporter, mediates cellular flavonoid uptake.J.H. Raatz, B. Cleveland and C. Rexroad III. USDA, Grand Forks Lee, Y. Kim and S-J. Lee. Col. of Life Sci. and Biotechnol., and Natl. Ctr. for Cool and Cold Water Aquacult., Kearneysville, Korea Univ. WV. D400 II 1079.32 Sweet potato skin provides health D384 II 1079.16 Isolation of anti-obesity active benefits in Caenorhabditis elegans model. C. Gao, M. King, compound orientin from Lythrum salicaria L. H.Y. Kim, K.Y. J. Finley, F. Greenway, M. Keenan, F. Enright, R. Martin, W. Lee, S-Y. Hong, S.H. Lim, K.H. Kim and S. Kim. Gangwondo Johnson and J. Zheng. LSU AgCtr. and Pennington Biomed. Agr. Res. and Ext. Svcs., Chuncheon-si and Kangwon Natl. Res. Ctr. Univ., South Korea. D401 I 1079.33 Kaempferia galanga L. suppresses D385 I 1079.17 L. reuteri NCIMB 30242: the sunshine melanin synthesis through inhibition of the CREB/MITF in B16 probiotic? M.L. Jones, C.J. Martoni and S. Prakash. McGill cells. B-K. Jeon, Y-J. Mun, W-H. Woo and Y-E. Lee. Wonkwang Univ. and Micropharma Ltd., Montreal. Univ., South Korea. D386 II 1079.18 Immunostimulatory effects of Curcuma D402 II 1079.34 Supercritical fluid extraction of anti- longa L. mulberry leaves, and purple sweet potato extracts : inflammatory polyacetylenes from celeriac Apium( graveolens modulation of immune functions during murine leukemia virus L.). B.T. Metzger, J.C. Waksmonski, A.L. Thompson and infection. S-A. Yoo, O-K. Kim, D-E. Nam, S-J. Park, D-K. Han, D.M. Barnes. Standard Process Inc., Palmyra, WI. H-O. Kwon and J. Lee. Kyung Hee Univ., South Korea. D403 I 1079.35 Comparison and purification of grape D387 I 1079.19 Polyphenolic content of sweet dried pomace extracts for inhibition of intestinal a-glucosidases. H.C. cranberries compared to cranberry juice cocktail. J. Marais Kadouh, S. Sun and K. Zhou. Wayne State Univ. and C. Khoo. Ocean Spray Cranberries Inc., Lakeville, MA.
364 TUESDAY NUTRITION
D404 II 1079.36 Characterization and quantitation of D418 II 1079.50 The dipeptide H-Trp-Glu-OH shows bioactive compounds in date fruit seed using UPLC-DAD-ESI- agonistic activity to PPAR-a, reducing hepatic lipid accumulation MS. H. Habib, C. Platat and W. Ibrahim. United Arab Emirates in lipid-loaded H4IIE cells. Y. Jia and S-J. Lee. Col. of Life Sci. Univ. and Biotechnol., Korea Univ. D405 I 1079.37 Bioactive micronutrients in rice varieties D419 I 1079.51 Anti-obesity effects of Cheonggukjang and their extraction efficiency. I.O. Minatel, G. Aldini, M. and Natto extract: from in vivo to in vitro study. C-B. Bae, M-S. Colzani, S-I. Han, C.R. Correa, D. Fecchio and K-J. Yeum. Byun, O-K. Yu, T-S. Park and Y-S. Cha. Chonbuk Natl. Univ., USDA at Tufts Univ., São Paulo State Univ., Botucatu Med. South Korea. Sch., Univ. of Milan and Natl. Inst. of Crop Sci., RDA, Miryang, D420 II 1079.52 Effect of replacing of pork fat with barley South Korea. flour in reduced-fat sausage on cholesterol concentrations in D406 II 1079.38 A flavonoid-rich apple extract inhibits C57BL6J mice. H. Minh Hien and S-J. Lee. Col. of Life Sci. growth of HCT116 human colon cancer cells. A. Morton, L. and Biotechnol., Korea Univ. Cao and L.D. Bourquin. Michigan State Univ. D421 I 1079.53 Fermented barley averts diet-induced D407 I 1079.39 Padiococcus acidilactici isolated from obesity via modulating the lipid metabolic gene expression in traditional Makgeolli inhibits lipid accumulation in 3T3-L1 Sprague Dawley rats. P.B.T. Pichiah, H-J. Moon, Y-J. Moon adipocyte and obesity in C57BL6J mice fed a high-fat diet. Y-J. and Y-S. Cha. Chonbuk Natl. Univ., South Korea. Moon, S-H. Baik and Y-S. Cha. Chonbuk Natl. Univ., South D422 II 1079.54 Biological activities of water-soluble Korea. sulfated polysaccharides from Ecklonia cava, Enteromorpha D408 II 1079.40 Anti-obesity effect of GTF extracts in prolifera and Monostroma nitidum. H. Minh Hien , J-Y. Kim high fat diet-induced obesity mice. S. Park, O-K. Kim, D-E. and S-J. Lee. Col. of Life Sci. and Biotechnol., Korea Univ. Nam, J-N. Ho, S-A. Yoo, D-K. Han, H-ol. Kwon and J. Lee. D423 I 1079.55 Baicalein inhibits lipid accumulation Kyung Hee Univ., South Korea. through regulation of MCE and cell cycle during 3T3-L1 D409 I 1079.41 Effect of storage temperature on the adipocyte differentiation. M-J. Seo, H-S. Choi, O-H. Lee and stability of fat-soluble micronutrients in rice varieties. I.O. B-Y. Lee. CHA Univ. and Kangwon Natl. Univ., South Korea. Minatel, D.T. Pierine, S-I. Han, C.R. Correa, D. Fecchio and D424 II 1079.56 Therapeutic effect of daily vinegar K-J. Yeum. USDA at Tufts Univ., Botucatu Med. Sch., State ingestion for individuals at risk for type 2 diabetes. C.S. Univ. of São Paulo and Natl. Inst. of Crop Sci., RDA, Miryang, Johnston, S. Quagliano and S. Loeb. Arizona State Univ. South Korea. D425 I 1079.57 Suppression of TPA-induced invasion of D410 II 1079.42 Ex vivo anti-adhesion activity of a HepG2 cells by glyceollins. J-S. Kim, I.S. Park, H.J. Kim, S.S. proanthocyanidin standardized cranberry powder beverage. Kim, H.R. Kang, B.R. Kim, A. Zakharova and J.Y. Seo. Schs. K.L. Kaspar, A.B. Howell and C. Khoo. Ocean Spray of Applied Biosci. and Food Sci. and Biotechnol., Kyungpook Cranberries Inc., Lakeville, MA and Rutgers, The State Univ. of Natl. Univ., South Korea. New Jersey, Chatsworth. D426 II 1079.58 Endotoxin neutralization activity of D411 I 1079.43 Acute toxicity of lotus (Nelumbo bovine plasma and bovine immunoglobulin (IgG)-rich fractions nucifera) seed ethanol extract in ICR mice. J.S. You, S.H. Kim, as compared to human plasma. E.M. Weaver, G.L. Klein, B.K. Y.J. Lee, S.Y. Kim, X. Zhao and K.J. Chang. Inha Univ. and DeVries, K. Maas and A.L. Shaw. Entera Hlth. Inc., Ankeny, IA Konkuk Univ., South Korea. and Cary, NC. D412 II 1079.44 Single dose oral toxicity of the lotus D427 I 1079.59 Effects of a high fat/high fructose (Nelumbo nucifera) root ethanol extract in ICR mice. J.S. You, diet on brain mitochondria are counteracted by cinnamon in S.H. Kim, Y.J. Lee, S.Y. Kim, X. Zhao and K.J. Chang. Inha stressed rats. C. Batandier, L. Poulet, F. Canini, K. Couturier, Univ. and Konkuk Univ., South Korea. I. Hininger-Favier, R.A. Anderson and A-M. Roussel. Univ. D413 I 1079.45 Serum-derived bovine immunoglobulin Joseph Fourier, Grenoble, Army Res. Ctr., La Tronche, France isolate as a potential therapy for inflammatory bowel disorders. and USDA, Beltsville. G.L. Klein, E. Weaver, A.L. Shaw and J. Cohn. Entera Hlth. D428 II 1079.60 Evaluation of pumpkins as a novel T Inc. and Tab Clin. Trials Inc., Cary, NC. source for a-carotene. M. Kemp, J. Dever, A. Thompson, B. D414 II 1079.46 The natural carotenoid astaxanthin, Metzger and D. Barnes. Standard Process, Palmyra, WI. U a PPAR modulator, ameliorates hepatic steatosis in C57BL6 D429 I 1079.61 Systematic review of wild rice: an E mice. Y. Jia and S-J. Lee. Grad. Sch. of Biotechnol. and Col. of ancient grain with modern benefits. D.A. Timm and J. Slavin. Life Sci. and Biotechnol., Korea Univ. Univ. of Minnesota-Twin Cities. D415 I 1079.47 In vitro inhibition of dipeptidyl peptidase D430 II 1079.62 Inhibitory effect of Canavalia gladiata IV by amaranth peptides. A.J. Velarde-Salcedo, S. Lara- extract on gastric inflammation induced by acute ethanol González, G.M. Monero-Morán, E. Gonzalez de Mejia and treatment in SD rats. O.K. Kim, J-N. Ho, D-A. Nam and J. Lee. A.P. Barba de la Rosa. IPICyT, San Luis Potosi, Mexico and Kyung Hee Univ., South Korea. Univ. of Illinois, Urbana. D431 I 1079.63 Effect of a Korean, 2010 Dietary D416 II 1079.48 NIH/ODS Analytical Methods and Guidelines for Americans, and typical American diet on fecal Reference Materials Program: accomplishments and future microbiota composition of overweight adults. G.I. Solano- directions. J.M. Betz, L.G. Saldanha, G.L. Cragg, B.C. Sorkin Aguilar, M. Kang, N. Schroeder, S. Lakshman, B. Vinyard, and P.M. Coates. ODS, NIH. G. Ha, Y. Kim, Y. Park, H. Kim, A. Yates and B. Caballero. D417 I 1079.49 Protective effect of GSW against UVB- USDA, Beltsville, Natl. Acad. of Agr. Sci., Suwon, South Korea induced skin damage. O-K. Kim, J-N. Ho, D-E. Nam and J. and Johns Hopkins Univ. Lee. Kyung Hee Univ., South Korea.
365 NUTRITION TUESDAY
D432 II 1079.64 Measurement of the whole blood 1081. NUTRIENT REGULATION OF EPIGENETICS IN transcriptomic signatures in healthy elderly subjects fed the MATERNAL PROGRAMMING probiotic bacteria Lactobacillus rhamnosus GG ATCC 53103 (LGG). G.I. Solano-Aguilar, A. Molokin, C. Botelho, A-M. Poster Fiorino, C. Chen, J. Urban, H. Dawson, M. Haverkamp, L. (Sponsored by: Nutrient-Gene Interactions RIS) Wang and P. Hibberd. USDA, Beltsville and Massachusetts Gen. Hosp. for Children. Tue. 7:30 am—Boston Convention & Exhibition Center, D433 I 1079.65 Glucosamine sulfate attenuates dextran Exhibit Halls A-B sodium sulfate induced colitis in mice. Y-K. Bak, J.W. Lampe and M-K. Sung. Sookmyung Women’s Univ., South Korea and Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) Fred Hutchinson Cancer Res. Ctr. D441 I 1081.1 Obesogenic phenotype of offspring of dams fed a high multivitamin diet is prevented by a post- 1080. NUTRIENT CONTROL OF PROTEOMICS AND weaning high multivitamin or high folate diet. C.E. Cho, D. METABOLOMICS Sanchez-Hernandez, S.A. Reza-Lopez, P.S.P. Huot, Y-I. Kim and G.H. Anderson. Univ. of Toronto and St. Michael’s Hosp. Poster D442 II 1081.2 Maternal obesity and post-natal high fat diet disrupt hepatic circadian rhythm in rat offspring. K. (Sponsored by: Nutrient-Gene Interactions RIS) Shankar, S.J. Borengasser, J. Faske, P. Kang and H. Gomez- Tue. 7:30 am—Boston Convention & Exhibition Center, Acevedo. Arkansas Children’s Nutr. Ctr. and Univ of Arkansas Exhibit Halls A-B for Med. Sci.
Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) 1082. ANIMAL RESEARCH MODELS FOR D434 I 1080.1 Dietary C20-22 w3 PUFA regulate MACRONUTRIENT METABOLISM hepatic oxidized PUFA levels and attenuate markers of diet- induced non-alcoholic steatohepatitis in Ldlr-/- mice. C.M. Poster Depner, K.M. Bohren, E. Morin-Kensicki and D.B. Jump. (Sponsored by: Experimental Animal Nutrition RIS) Oregon State Univ., USDA, Baylor Col. of Med. and Metabolon Inc., Durham, NC. Tue. 7:30 am—Boston Convention & Exhibition Center, D435 II 1080.2 Vitamin D status impacts serum Exhibit Halls A-B metabolomic profiles in pregnant adolescents. J.L. Finkelstein, Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) E.K. Pressman, E.M. Cooper, T.R. Kent and K.O. O’Brien. Cornell Univ. and Univ. of Rochester Med. Ctr. D443 I 1082.1 Effects of a high fat or a high D436 I 1080.3 Caffeine intake and the plasma carbohydrate diet and exercise on energy substrate utilization proteome. O. Tian, A.R. Josse and A. El-Sohemy. Univ. of in rat brain. X. Minjun, T. Sonou, T. Fujii, A. Nakashima, C. Toronto. Tanaka and K. Okamura. Osaka Univ. of Hlth. and Sport Sci. D437 II 1080.4 A genome-wide association study of D444 II 1082.2 Protein turnover in pregnant pigs when the human plasma proteome. J. Jamnik, B. Garcia-Bailo, C. feeding limiting amounts of amino acids. S. Moehn, M. Rafii, Borchers and A. El-Sohemy. Univ. of Toronto and Univ. of P.B. Pencharz and R.O. Ball. Univ. of Alberta and The Hosp. Victoria, Canada. for Sick Children, Toronto. D438 I 1080.5 Hyperglycemia mediates a shift from D445 I 1082.3 Expression of transcription factors cap-dependent to cap-independent mRNA translation through involved in lipid metabolism in mice fed algae, yeast, or fish oil. a 4E-BP1 dependent mechanism. M.D. Dennis, S.R. Kimball L.T. Clevenger, K. Barnes, J. Ketz and M. Rodavich. West and L.S. Jefferson. Penn State Col. of Med. Virginia Univ. D439 II 1080.6 Lower plasma DHA and EPA and their D446 II 1082.4 Impact of high saturated lipids diet related oxylipins are potential contributors to vascular disease on serum fatty acid profile in rats. P.D. Perris, C. Silva, I. in hemodialysis patients. B.A. Watkins, J. Kim, S. Kaiser, A.N. Fernandez, C. Mambrin, N. Slobodianik and M.S. Feliu. Sch. Friedman, Y. Li, T.L. Pedersen and J.W. Newman. Univ. of of Nutr., Fac. of Pharm. and Biochem., Univ. of Buenos Aires. Connecticut, Indiana Univ. Sch. of Med. and USDA, Davis. D440 I 1080.7 Effects of antenatal micronutrient 1083. ANIMAL RESEARCH MODELS INVESTIGATING supplementation on plasma protein profiles in Nepalese NUTRITION AND INFLAMMATION children. S.E. Lee, K.P. West, Jr., R.N. Cole, I. Ruczinski, K. Schulze, J.D. Yager, J. Groopman and P. Christian. Johns Poster Hopkins Bloomberg Sch. of Publ. Hlth. and Johns Hopkins Sch. of Med. (Sponsored by: Experimental Animal Nutrition RIS)
Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B
LAST DAY TO Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) VISIT EXHIBITS D447 I 1083.1 Porcine prepubertal obesity is associated with altered adipokine mRNA in visceral and Tuesday, April 23 subcutaneous fat. W. Zhang, J. Scheffler, J. Escobar, H. 9:00 AM – 4:00 PM Reeves, G. Van Eyk, K. Fisher, K. Seelenbinder, K. Price, T. Scheffler, X. Zhao and E. Gilbert. Virginia Tech, Novus Intl. Inc., Charles, MO and Sichuan Agr. Univ., China. 366 TUESDAY NUTRITION/PATHOLOGY
D448 II 1083.2 Development of a piglet model of D456 II 1083.10 Dietary supplementation with a low dose neonatal systemic Staphylococcus aureus infection. E.A. of (-)-epigallocatechin-3-gallate reduces pro-inflammatory Reznikov, J.L. Hoeflinger, M.H. Monaco, M.J. Miller and S.M. response in peripheral leukocytes of non-obese type 2 diabetic Donovan. Univ. of Illinois, Urbana. GK rat. Y. Uchiyama and K. Mochizuki. Univ. of Shizuoka and D449 I 1083.3 Dietary açai fruit improves cognition Univ. of Yamanashi, Japan. and mobility in aged rats. M.G. Miller, D.R. Fisher, A.N. Carey, S.M. Poulose and B. Shukitt-Hale. Tufts Univ., USDA at Tufts 1084. ANIMAL RESEARCH MODELS IN NUTRITION Univ. and Simmons Col. AND MUSCULOSKELETAL DEVELOPMENT D450 II 1083.4 The protective effects of alginate and fucoidan from the brown seaweed on the alcohol-induced liver Poster damage. T. Kim, Y-J. Kim, J.D. Lim and E-H. Sohn. Kangwon Natl. Univ., South Korea. (Sponsored by: Experimental Animal Nutrition RIS) D451 I 1083.5 Blueberry supplementation improves Tue. 7:30 am—Boston Convention & Exhibition Center, memory in middle aged mice consuming a high fat diet. A.N. Exhibit Halls A-B Carey and B. Shukitt-Hale. Simmons Col. and USDA at Tufts Univ. Presentation time: 12:45 pm-1:45 pm (I); 1:45 pm-2:45 pm (II) D452 II 1083.6 Improved insulin sensitivity and reduced D457 I 1084.1 Amiloride derivative phenamil adiposity with aP2 driven TLR4 overexpression in transgenic restricts long bone growth in broilers in conjunction with zinc mice. K.D. Ono-Moore, L. Zhao, S. Huang, J-a. Kim, J.M. accumulation. T. Price, K.L. Moncada, K.W. Park, P. Tontonoz Rutkowsky, R.G. Snodgrass, D.A. Schneider, M.J. Quon and R.L. Walzem. Texas A&M Univ., Sungkyunkwan Univ., and D.H. Hwang. Univ. of California, Davis, USDA, Davis, Univ. South Korea and HHMI, UCLA. of Tennessee, Knoxville, Univ. of Alabama at Birmingham and D458 II 1084.2 The effects of silk fibroin on bone Univ. of Maryland Baltimore. metabolism in ovariectomized rats. S.H. Shin, JY. Yoon, J-W. D453 I 1083.7 The effect of omega-3 polyunsaturated Chon, K-G. Lee, H.Y. Kweon, Y-Y. Jo, H-S. Lee and Y-K. Park. fatty acid and soy protein isolate supplementation on kidney Grad. Sch. of East-West Med. Sci., Kyung Hee Univ. and Natl. function in female polycystic kidney diseased rats. K.H. Maditz, Acad. of Agr. Sci., Suwon, South Korea. K. Mock, A. Knecht, N. Nanda, C. Oldaker and J. Tou. West D459 I 1084.3 High resolution in vivo micro- Virginia Univ. computed tomography is preferential over dual energy X-ray D454 II 1083.8 Effects of dietary protein and vitamin A absorptiometry for detecting bone loss in the orchidectomized on retinoids and retinol binding protein in periparturient rats. F. guinea pig. I.L. Mak, J.R. DeGuire, P. Lavery, S. Agellon and Foroudi, K.C. Ramsey and P. Rezamand. Univ. of Idaho. H.A. Weiler. Sch. of Dietetics and Human Nutr., McGill Univ. D455 I 1083.9 Protective effects of ellagic acid on D460 II 1084.4 Distinct role of Rheb and Grb10 in the ethanol-induced toxicity in hepatic HepG2 cells. Y-J. Kim, T. regulation of mTORC1 signaling in skeletal muscle of neonatal Kim, S. Namkoog and E-H. Sohn. Kangwon Natl. Univ., South pigs. A. Suryawan, H.V. Nguyen and T.A. Davis. USDA, Baylor Korea. Col. of Med.
Pathology
1085. PATHOPHYSIOLOGY OF CARDIOVASCULAR Municipal Clin. Emer. Hosp. No.1, Orenburg and Kirov Military DISEASE Med. Acad., Russia. A393 1085.4 Search for plasma biomarkers for dilated T Poster cardiomyopathy using a mouse model with sialyltransferase U transgenes. O. Suzuki. Natl. Inst. of Biomed. Innovation, E Tue. 7:30 am—Boston Convention & Exhibition Center, Ibaraki-shi. Exhibit Halls A-B A394 1085.5 P2Y2 receptor deficiency reduces vascular Presentation time: 11:45 am-1:45 pm inflammation and atherosclerosis in mice.C. Seye. Indiana Univ. Sch. of Med. A390 1085.1 Exercise training on left ventricular interstitial A395 1085.6 Reduced BDNF attenuates inflammation and collagen in spontaneously hypertensive rats. L.U. Pagan, angiogenesis to improve survival and cardiac function following R. Damatto, M. Cezar, A. Lima, C. Bonomo, D. Guizoni, myocardial infarction in mice. G.V. Halade, Y. Ma, T.R. Ramirez, P. Martinez, R. Gimenes, M. Okoshi and K. Okoshi. Univ. J. Zhang, Q. Dai, J.G. Hensler, E.F. Lopez, O. Ghasemi, Y-F. Estadual Paulista-UNESP, Botucatu, Brazil. Jin and M.L. Lindsey. Univ. of Texas Hlth. Sci. Ctr. and Univ. of A391 1085.2 The possible role of serum from septic Texas at San Antonio. mice in dystrophin proteolysis in cultured newborn mice A396 1085.7 Pressure overload amplifies IL-18 signaling cardiomyocytes. L.M.M. Malvestio, C.M. Prado, M.R.N. Celes, in a rabbit model of myocardial hypertrophy and failure. T. E.C. Campos, P.M. Ferezin and M.A. Rossi. Univ. of São Yoshida, M. Srinivas, I. Friehs, P.J. del Nido, N. Somanna, Paulo, Ribeirão Preto. A.J. Valente and B. Chandrasekar. Tulane Univ. Sch. of Med., A392 1085.3 Chronic hypoestrogenism promotes apoptotic Univ. of Texas Hlth. Sci. Ctr. at San Antonio and Harvard Med. death in cardiac myocytes of the left ventricular myocardium. Sch. Y.V. Liskova , E.A. Kovalevskaya, S.P. Salikova, A.A. Stadnikov and E.V. Blinova. Orenburg State Med. Acad.,
367 PATHOLOGY TUESDAY
A397 1085.8 Influence of late exercise training on myostatin 1086. CELL STRESS AND CELL DEATH and follistatin expression in soleus muscle of rats with chronic heart failure. D.M. Guizoni, S.A. Oliveira Junior, P.F. Martinez, Poster A.R.R. Lima, C. Bonomo, R.L. Damatto, M.D.M. Cezar, L.U. Pagan, L.A.M. Zornoff, K. Okoshi and M.P. Okoshi. Botucatu Tue. 7:30 am—Boston Convention & Exhibition Center, Med. Sch., Brazil. Exhibit Halls A-B A398 1085.9 Adiponectin inhibits leptin-induced Presentation time: 11:45 am-1:45 pm cardiomyocyte hypertrophy by attenuation of calcineurin/NFAT activation. V. Rajapurohitam, B. Suen and M. Karmazyn. A410 1086.1 Mechanism underlying the antioxidant activity Univ. of Western Ontario. of taurine. C.J. Jong and S. Schaffer. Univ. of South Alabama. A399 1085.10 Muscle ring finger 1 (MuRF1) and MuRF2 A411 1086.2 Modulation of autophagy affects the hepatic regulate gene expression mediated by the E2F transcription pathology in alcoholic and non-alcoholic liver diseases. H. factors and are necessary but functionally redundant during Zhang, B. Khambu, X. Chen and X-M. Yin. Indiana Univ. Sch. developmental cardiac growth in vivo. M.S. Willis, K.M. of Med. Wadosky and C. Patterson. Univ. of North Carolina at Chapel A412 1086.3 Autophagy in neuronal bioenergetics and Hill. survival. J. Zhang, M. Dodson, Q. Liang, G. Benavides and A400 1085.11 Cardiomyocytes hypertrophy in vitro are V.M. Darley-Usmar. Univ. of Alabama at Birmingham and induced by TLR2 and TLR4 agonists through NF-kB pathway. Birmingham VA Med. Ctr. F.G. Silva and M.S.C. Ramos. Fed. Univ. of ABC, Brazil. A413 1086.4 Induction of apoptosis in the bone marrow A401 1085.12 Expression of cardiolipin biosynthesis and promotes regenerative actions of parathyroid hormone in remodeling enzymes in adult heart failure. J.E. Grudis, K.C. bone. A.J. Koh, S.W. Cho, P. Entezami, G. Pettway and L. Chatfield, G.C. Sparagna, J. Hijmans, R.D. Sobus, C.C. McCauley. Univ. of Michigan. Sucharov, S.D. Miyamotto and B.L. Stauffer. Sch. of Med., A414 1086.5 Role of bile acids in autophagy and alcohol- Univ. of Colorado Denver, Children’s Hosp. Colorado, Aurora, induced liver injury. S. Manley, H. Ni, H. Yang, G. Guo, U. Apte Univ. of Colorado Boulder and Univ. of Colorado Denver, and W-X. Ding. Univ. of Kansas Med. Ctr. Aurora. A415 1086.6 Autophagy in pituitary tumors. F. Rotondo, E. A402 1085.13 New susceptibility locus for obesity and Horvath, K. Kovacs, L.V. Syro and S. Yamada. St. Michael’s dyslipidemia on chromosome 3q22.3. N. Dzimiri, M. Al-Najai, Hosp., Toronto, Pablo Tobon Uribe Hosp., Medellin, Colombia P. Muiya, E. Andres, N. Mazher, M. Alshahid and B.F. Meyer. and Toranomon Hosp., Tokyo. King Faisal Spec. Hosp. and Res. Ctr., Saudi Arabia. A416 1086.7 Prolonged NLRP3 inflammasome activation A403 1085.14 The HNF1a is a susceptibility gene for enhances the secretion of autophagy-derived vesicles myocardial infarction and dyslipidaemia. P. Muiya, M. Al- containing LC3II in murine dendritic cells. H.M. Russo and Najai, N. Mazher, E. Andres, M. Alshahid, B.F. Meyer and N. G.R. Dubyak. Case Western Reserve Univ. Dzimiri. King Faisal Spec. Hosp. and Res. Ctr., Saudi Arabia. A417 1086.8 Caspase-generated neoepitopes as markers A404 1085.15 Evaluation of the HNF1a gene as a risk factor of axonal degeneration in neural development and injury. J.D. for metabolic syndrome in the Saudi population. D.M. Bakheet, Sokolowski, D.S. Heffron, C. Deppmann, A.C. LeBlanc and M. Al-Najai, N. Mazher, S. Elhawwari, E. Andres, M. Alshahid, J.W. Mandell. Univ. of Virginia and McGill Univ. P. Muiya, B.B. Meyer and N. Dzimiri. King Faisal Spec. Hosp. A418 1086.9 Evaluation of antioxidant defense in patients & Res. Ctr., Saudi Arabia. undergoing minor elective surgery with balanced anesthesia A405 1085.16 Examining the role of cytoskeletal signaling maintained with the inhaled isoflurane. M.G. Braz, D. Salvadori, in cardiac preconditioning. A.J. Perricone, B.J. Bivona, F.R. L. Braz, J.R. Braz, G. Tang and K-J. Yeum. São Paulo State Jackson and R.S. Vander Heide. LSU Hlth. Sci. Ctr. , New Univ. and USDA at Tufts Univ. Orleans. A419 1086.10 PGC-1 isoforms modulate the antioxidant A406 1085.17 Physical rehabilitation based on the response of photoreceptors to photo-oxidative stress. J. phenomenon of ischemic preconditioning in patients with Iacovelli, Z. Arany and M. Saint-Geniez. Schepens Eye Res. ischemic heart disease. N.P. Lyamina, E.V. Kotelnikova, E.S. Inst., Mass Eye and Ear Infirm., Harvard Med. Sch. and Beth Karpova, V.N. Senchikhin, S.V. Lyamina, H.F. Downey and Israel Deaconess Med. Ctr. E.B. Manukhina. Saratov Res. Inst. of Cardiol., Moscow State A420 1086.11 Low respiratory quotients in chow-fed male Univ. of Med. and Dent., Univ. of North Texas Hlth. Sci. Ctr. and bonnet macaque monkeys as an indicator of metabolic stress Inst. of Gen. Pathol. and Pathophysiol., Moscow. due to single cage housing. R. Rising and J. Lin. D & S A407 1085.18 Deficiency of apoptosis inducing factor Consulting Svcs. Inc., New York and Plexxikon Inc., Berkeley. decreases complex I activity and increases the ROS generation A421 1086.12 High MUC2 production in goblet cells caused in isolated cardiac mitochondria. K. Szczepanek, Y. Hu, E. ER stress and susceptibility to apoptosis. A.A. Tawiah, F. Lesnefsky and Q. Chen. Virginia Commonwealth Univ. and Moreau and K. Chadee. Univ. of Calgary, Canada. McGuire VA Med. Ctr. A422 1086.13 Cisplatin nephrotoxicity involves mitochondrial A408 1085.19 Plasma Hsp27 and phosphorylated Hsp27 injury with impaired tubular mitochondrial enzyme activity. Z.K. levels as biomarkers of cardiovascular disease. W.T. Zsengeller, P. Mukhopadhyay, B. Kalyanaraman, S. Parikh, Gerthoffer, L.T. Muphy, C. Malozzi and C.V. Massey. Univ. of A.S. Karumanchi, I.E. Stillman and P. Pacher. Beth Israel South Alabama. Deaconess Med. Ctr., NIAAA, NIH and Med. Col. of Wisconsin. A409 1085.20 Reactive oxygen species and electron flow are A423 1086.14 Cigarette smoking affects human semen needed to oxidize cytochrome c at the methionine residues. quality in synergy with functional Nrf2 polymorphisms. Z. H.S. Aluri, Q. Chen, Y. Hu and E.J. Lesnefsky. Virginia Huang and B. Yu. Sun Yat-sen Univ. and Third Affiliated Hosp. Commonwealth Univ. and McGuire VA Med. Ctr. of Guangzhou Med. Univ., China.
368 TUESDAY PATHOLOGY
A424 1086.15 Cigarette smoke-induced myocardial A436 1087.11 IFN-gamma specifically targets melanoma inflammation and contractile dysfunction is mediated by stem cells and inhibits in vitro spherogenic growth. C-W. Lee, J. unsaturated aldehydes and TRPV1. E.Y. He, Z. Wu, G.I. Scott Huang, Y-T. Chuang and G.F. Murphy. Brigham and Women’s and J. Ren. Univ. of Wyoming, Fourth Military Med. Univ., Hosp. , Harvard Med. Sch. and Boston Children’s Hosp. China. A437 1087.12 Association of HER2 Ile655Val and Ala1170Pro A425 1086.16 Bromelain prevents mouse testis from tert-butyl polymorphisms with breast cancer prognosis factors. D. Furrer, hydroperoxide-induced dysfunction by inhibiting apoptosis, C. Laflamme, M-A. Côté, L. Provencher, F. Barabé, S. Jacob, inflammation, and cellular senscence.Y-C. Yeh, C-H. Tsai, C. St-Pierre, É. Demers, R. Tremblay-LeMay, C. Nadeau- T-J. Liu, H-C. Lai and L-C. Wang. Nanhua Univ. and Taichung Larochelle, A. Michaud, J. Lemieux and C. Diorio. Res. Ctr. Veterans Gen. Hosp., Taiwan. CHUQ, Laval Univ. Canada. A438 1087.13 An interleukin-15 fusion protein enhances the 1087. INTRA- AND EXTRACELLULAR BIOLOGY OF oncolytic effects of myxoma virus in a murine melanoma model. MALIGNANCY A.L. MacNeill, V. Tosic, R.A. Doty, J. Liu, G. McFadden and E.J. Roy. Univ. of Illinois, Urbana and Univ. of Florida. Poster A439 1087.14 Anti-angiogenic activity of alpha7-nicotinic receptor antagonists in human small cell lung cancer. B.A. Tue. 7:30 am—Boston Convention & Exhibition Center, Thornhill, K.C. Brown, J.K. Lau, A.M. Dom, T.R. Witte, W.E. Exhibit Halls A-B Hardman, H. Luo, Y.C. Chen and P. Dasgupta. Joan C. Edwards Sch. of Med., Marshall Univ. and Alderson-Broaddus Presentation time: 11:45 am-1:45 pm Col., WV. A426 1087.1 Proteomic profiling of thyroid follicular A440 1087.15 Role of C-terminal domain of E-cadherin in adenoma. X. Lai. Indiana Univ. Sch. of Med. activating b-catenin/TCF pathway in cancer cells under hypoxic A427 1087.2 Floating cultured melanoma cells are a distinct conditions. H. Sellak, S. Wu and T.M. Lincoln. Georgia Hlth. subpopulation enriched for cancer stem cell biomarkers. J. Sci. Univ. and Univ. of South Alabama. Huang, C-W. Lee, Y-T. Chuang and G.F. Murphy. Brigham A441 1087.16 Cav1 is a key mediator of tumor-stromal and Women’s Hosp., Harvard Med. Sch. and Boston Children’s interactions in melanoma. C. Trimmer and F. Capozza. Hosp. Thomas Jefferson Univ. A428 1087.3 Interaction of MCM7 and RACK1 for activation A442 1087.17 WNT5a-mediated tumor suppression of of MCM7 and cell growth. X. Zhang, Y.P. Yu and J-H. Luo. Univ. esophageal adenocarcinoma in vitro. T. Moore, O. Lyros, L. of Pittsburgh. Nie, N. Jovanovic, R. Medda, T. Perkins, M. Otterson and R. A429 1087.4 Patterned laminin expression by spheroid- Shaker. Med. Col. of Wisconsin. forming melanoma cells. A.R. Larson, C. Lezcano, C-W. Lee, A443 1087.18 Are the intrarenal hormones the culprit in renal J. Huang, Q. Zhan and G.F. Murphy. Brigham and Women’s cell carcinoma? C.A. Jackson and D.D. Canionero. Tuskegee Hosp., Harvard Med. Sch. Univ. A430 1087.5 Scanning acoustic microscopy for A444 1087.19 Epigenetic regulation of PTEN in hepatic characterization of gastric lesions. K. Miura and S. Yamamoto. cancer. X.V. Qadir, C. Han and T. Wu. Tulane Univ. Sch. of Med. Hamamatsu Univ. Sch. of Med., Japan. A431 1087.6 High prevalence of Chlamydophila psittaci 1088. ADVANCES IN DIAGNOSIS AND TREATMENT subclinical infection in Italian patients with Sjögren’s syndrome OF MALIGNANCY and parotid gland B-cell lymphoma. M. Fabris, R. Dolcetti, E. Pasini, L. Quartuccio, E. Pontarini, M. Ponzoni, C.A. Scott, Poster F. Curcio and S. De Vita. Univ. Hosp. of Udine, NCI of Aviano, Humanitas Clin. Inst., Rozzano (Milan) and San Raffaele Sci. Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Inst., Milan. T A432 1087.7 Identification of PKM2 interacting proteins by Presentation time: 11:45 am-1:45 pm tandem mass spectrometry. S.R. Hwang, S.R.P. McDonnell, V. U Basrur, K.P. Conlon, D. Fermin, C. Murga-Zamalloa, K.S.J. A445 1088.1 Role of HO-1 in neuroblastoma resistance E Elenitoba-Johnson and M.S. Lim. Univ. of Michigan. to bortezomib. A. Furfaro, S. Piras, M. Passalacqua, C. A433 1087.8 Expression of MDR-transporter, ABCB5, in Domenicotti, M.A. Pronzato, U.M. Marinari, L. Moretta, N. Merkel cell carcinoma. C. Lezcano, S. Kleffel, A.C. Laga, Traverso and M. Nitti. Univ. of Genoa and Giannina Gaslini Q. Zhan, A. DoRosario, M.H. Frank, L. Wang, G.F. Murphy Inst., Genoa. and T. Schatton. Brigham and Women’s Hosp., Dana-Farber A446 1088.2 mTOR inhibition leads to decrease of breast Cancer Inst., Children’s Hosp. Boston and Mercy Med. Ctr., cancer progression in vitro via cytoskeleton remodeling. O. Baltimore. Cherednyk, A. Khoruzhenko, V. Kosach and V. Filonenko. A434 1087.9 cGMP-dependent protein kinases (PKG-Ib and Inst. of Molec. Biol. and Genet., NAS of Ukraine, Kiev. PKG-II) modulate b-catenin/TCF pathway in cancer cells. H. A447 1088.3 The pMAPK/pAMPK ratio modulates the Sellak, S. Wu and T.M. Lincoln. Georgia Hlth. Sci. Univ. and effect of adiponectin on breast cancer cell growth. L. Mauro, Univ. of South Alabama. M. Pellegrino, E. Ricchio, F. De Amicis, S. Catalano, D. A435 1087.10 Differential antibody responses to HPV16 in Bonofiglio, P. Rizza, M.L. Panno and S. Andò. Univ. of cervical and oropharyngeal cancer. E.R. Unger, G. Panicker, Calabria, Italy. J. Wong, G. Wallstrom, R. Haddad, G. D’Souza, M. Posner A448 1088.4 Combinatorial treatment of malignant and K.S. Anderson. Ctrs. for Dis. Control and Prevent., Dana- peripheral nerve sheath tumors with tyrosine kinase inhibitors Farber Cancer Inst., Arizona State Univ., Johns Hopkins Sch. hinders proliferation and survival. S.N. Brosius, K.A. Roth and of Publ. Hlth. and Mount Sinai Sch. of Med. S.L. Carroll. Univ. of Alabama at Birmingham.
369 PATHOLOGY/PHARMACOLOGY TUESDAY
A449 1088.5 Aptamer-drug conjugates for targeted therapy A457 1088.13 Development of experimental protocol for of CD30-expressing lymphomas. P.A. Parekh, S.R. Kamble, Z. photodynamic therapy on colorectal tumors: determination Zihua and Y. Zu. The Methodist Hosp. Res. Inst., Houston. of irradiation by fluorescence spectroscopy. J. Duarte, A.O. A450 1088.6 A targeted iron-based MRI contrast for tumor Ferreira, L. Silveira, Jr. and H. Plapler. Univ. Paulista, São detection. D.R. Mills, E.G. Walsh, K.E. Brilliant, D.C. Hixson Jose dos Campos, Fed. Univ. of São Paulo and Univ. Camilo and W.K.C. Park. Rhode Island Hosp. and Brown Univ. Castelo Branco, Brazil. A451 1088.7 An ultra pH-sensitive and aptamer-equipped A458 1088.14 p38MAPK inhibition: a new combined approach hollow gold nanosphere for selective killing of tumor cells. N. to reduce neuroblastoma resistance under etoposide treatment. Zhao, J. You, Z. Zeng, C. Li and Y. Zu. The Methodist Hosp. B. Marento, R. Ricciarelli, C. De Ciucis, A. Furfaro, R. Colla, Res. Inst. and Univ. of Texas MD Anderson Cancer Ctr. E. Canepa, N. Traverso, U.M. Marinari, M.A. Pronzato and C. A452 1088.8 Comparison of micro-bubble assisted p53, Domenicotti. Univ. of Genoa. pRB, and p130 gene therapy in combination with radiation A459 1088.15 Inhibition of lysine-specific histone demethylase therapy in prostate cancer in vitro and in vivo. R.P. Nande, LSD1 suppresses melanoma growth. C.G. Lian, R. Fang, Q. M.S. Gossman, J.P. Lopez, C.M. Howard, J. Denvir and Zhan, J. Ma, C-W. Lee, M.H. Frank, Y.G. Shi and G.F. Murphy. P.P. Claudio. Marshall Univ. and Tri-State Reg. Cancer Ctr., Brigham and Women’s Hosp., Harvard Med. Sch. and Boston Ashland, KY. Children’s Hosp. A453 1088.9 Development of ssDNA-based aptamers A460 1088.16 Targeting retinoblastoma: therapeutic inhibition specific to PSMA. B. Yuan, N. Zhao, S-n. Pei and Y. Zu. The using catalytic antioxidant cerium oxide nanoparticles. K.E. Methodist Hosp. Res. Inst., Houston. Klump, X. Cai, R. Towner, S. Seal, M. Dyer and J. McGinnis. A454 1088.10 In vivo murine lymph node imaging Univ. of Oklahoma Hlth. Sci. Ctr., Oklahoma Med. Res. Fndn., with multispectral photoacoustic technology and clinical Univ. of Central Florida and St. Jude Children’s Res. Hosp. contrast agents. A. Heinmiller, C. Hupple, A. Needles, C. A461 1088.17 Mouse models of cancer—how to optimize Theodoropoulos and R.W. Wood. VisualSonics Inc., Toronto their predictive value in cancer drug development. G.S. Herter- and Univ. of Rochester Med. Ctr. Sprie and K-K. Wong. Dana-Farber Cancer Inst. and Harvard A455 1088.11 MG624, a synthetic small molecule alpha7 Med. Sch. receptor antagonist, inhibits growth of human small cell lung A462 1088.18 Develop a novel aptamer-mediated assay for cancer. C.A. McNees, K.C. Brown, J.K. Lau, A.M. Dom, B. simultaneous detection of different types of circulating tumor Shiflett, T.R. Witte, W.E. Hardman, H. Luo, Y.C. Chen, A.B. cells in whole blood samples. Z. Zeng, P. Parekh, N. Zhao and Carpenter and P. Dasgupta. Joan C. Edwards Sch. of Med., Y. Zu. The Methodist Hosp., Houston. Marshall Univ. and Alderson-Broaddus Col., WV. A463 1088.19 Molecular histology with high resolution A456 1088.12 Withdrawn. imaging mass spectrometry. K. Kellersberger, J-M. Kowalski, M. Becker, S-O. Deininger and S. Cornett. Bruker Daltonics, Billerica, MA and Bremen, Germany.
Pharmacology and Experimental Therapeutics
1089. CARDIAC SIGNALING 1090. VASCULAR PHARMACOLOGY
Poster Poster
Tue. 7:30 am—Boston Convention & Exhibition Center, Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Exhibit Halls A-B
Presentation time: 12:30 pm-2:30 pm Presentation time: 12:30 pm-2:30 pm A1 1089.1 The inhibitory effect of cibenzolineon Na+/Ca2+ A5 1090.1 Alteration of endothelial CaMKII in AngII- exchange current in cardiac myocytes. Y. Watanabe and J. induced hypertensive mice. C. Charbel, F. Toussaint, A. Kimura. Hamamatsu Univ. and Fukushima Med. Univ., Japan. Blanchette and J. Ledoux. Montreal Heart Inst. and Univ. of A2 1089.2 H2S-induced cardiac protection is caused by Montreal. activation of mTORC2/Akt/Bim pathway in an isolated rat heart A6 1090.2 Adenosine A2A receptor modulates vascular ischemia/reperfusion model. Y. Zhou, D. Wang, X. Gao, K. response in soluble epoxide hydrolase-null mice through Lew, A. Richards and P. Wang. Natl. Univ. of Singapore, Putuo cyp2j-epoxygenases and PPARg. M.A. Nayeem, I. Pradhan, Hosp. and Huashan Hosp., Shanghai. S.J. Mustafa, C. Morisseau, J.R. Falck and D.C. Zeldin. A3 1089.3 Helium inhalation induces caveolin secretion West Virginia Univ., Univ. of California, Davis, Univ. of Texas to blood. N.C. Weber, J.M. Schilling, J.C. Finley, M. Irvine, Southwest Med. Ctr. and NIEHS, NIH, Research Triangle Park. S.E. Kellerhals, I.R. Niesman, D.M. Roth, B. Preckel, M.W. A7 1090.3 PAR-2 receptors modulate nerve-evoked Hollmann and H.H. Patel. Univ. of Amsterdam, UCSD and VA contraction of resistance arteries. P. Kerr, M. Zwozdesky, M. San Diego Healthcare Syst. Chen, R. Wei and F. Plane. Macewan Univ., Canada and Univ. A4 1089.4 Rapamycin-regulated ubiquitin specific of Alberta. peptidases expression in cardiocytes. A.V.D. Zanetti, L.C. Santos, V.A. Schoeps, P.S. Sanzovo, J.V.S. Carniello, A.A.S. Manso, F.W. Sellke and C. Bianchi. Rhode Island Hosp.
370 TUESDAY PHARMACOLOGY
A8 1090.4 Lipopolysaccharide increases agonist- 1092. VASCULAR SMOOTH MUSCLE SIGNALING induced contractile responses in Sprague Dawley rat corpus cavernosum. I.S. Stallmann-Jorgensen and R.C. Webb. Poster Georgia Hlth. Sci. Univ. A9 1090.5 Thrombospondin-1 impairs vasorelaxation Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B via signal regulatory protein-a-mediated activation of NADPH oxidase 1. M. Yao, G. Csanyi, A. Rodriguez, D. Roberts, P. Presentation time: 12:30 pm-2:30 pm Pagano and J. Isenberg. Midwestern Univ., AZ, Univ. of Pittsburgh and NCI, NIH. A20 1092.1 Abnormal calcium homeostasis in the aorta of A10 1090.6 Pharmacological interventions to overcome the spontaneously hypertensive rat is mediated by endoplasmic reactive oxygen species in hemorrhagic shock. M-F. Doursout, reticulum stress. K. Spitler and R.C. Webb. Georgia Hlth. Sci. Y. Liang and L. Vandelaar. Univ. of Texas Med. Sch. at Houston. Univ. A11 1090.7 Toll-like receptor 2 activation increases A21 1092.2 Differential contribution of pannexin-1 channels adrenergic sensitivity in mesenteric resistance vessels of rats. to agonist and neurogenic constriction of mesenteric arteries T.A. Hardigan, K.P. Nunes, T. Szasz and R.C. Webb. Georgia and veins from normotensive and DOCA-salt hypertensive rats. Hlth. Sci. Univ. J. Hernandez, H. Xu, S. Sangsiri and J. Galligan. Michigan State Univ. A22 1092.3 a1-Adrenergic receptor activation rapidly 1091. VASCULAR SIGNALING IN DIABETES upregulates L-type Ca2+ channels in rat mesenteric arteries in vivo. A.K. Srivastava, S.V. Kharade, T.W. Fletcher, S.W. Rhee Poster and N.J. Rusch. Univ. of Arkansas for Med. Sci. Tue. 7:30 am—Boston Convention & Exhibition Center, A23 1092.4 Modulation of vascular response by high salt Exhibit Halls A-B intake depends on the presence or absence of adenosine A2A receptor using A2A AR-null mice. I. Pradhan, S.J. Mustafa, Presentation time: 12:30 pm-2:30 pm D.C. Zeldin, C. Ledent, J.R. Falck and M.A. Nayeem. West A12 1091.1 Angiotensin-(1-7) stimulates mobilization of Virginia Univ., NIEHS, NIH, Research Triangle Park, Univ. Libre bone marrow stem/progenitor cells in diabetes. Y. Jarajapu, G. of Brussels and Univ. of Texas Southwestern Med. Ctr., Dallas. Vasam, R. Pawar and S. Bartelmez. North Dakota State Univ. A24 1092.5 Mechanism of glabridin-mediated vasorelaxa- and BetaStem Therapeut. Inc., San Francisco. tion of rat main mesenteric artery. P. Aaronson and D. Chanda. A13 1091.2 Toll-like receptor 4 mediates endothelial King’s Col. London. dysfunction during type I diabetes. M.A. Carrillo-Sepulveda, A25 1092.6 Dynein-mediated lysosome trafficking in K.P. Nunes and R.C. Webb. Georgia Hlth. Sci. Univ. autophagic flux of mouse coronary arterial myocytes.M. Xu, X. A14 1091.3 Cystathionine gamma-lyase deficiency impairs Li, Y. Zhang and P-L. Li. Virginia Commonwealth Univ. A26 Endothelial dysfunction accentuates the loss of H2S biosynthesis and vessel reactivity in type-2 diabetes. G.V. 1092.7 Velmurugan and C. White. Rosalind Franklin Univ. function of beta adrenergic receptors in the smooth muscle of A15 1091.4 Comparative analysis of the vascular the rat aorta during maturation. O. Lopez-Canales, J. Lopez- sympatho-inhibition to moxonidine in control or streptozotocin- Canales, G. Guevara-Balcazar, M.C. Castillo-Hernandez induced diabetic rats. D. Centurion, E. Moreno-Vázquez, M.T. and B. Escalante-Acosta. Med. Sch. and CINVESTAV del Villamil-Hernández, O. Alcántara-Vázquez, S.J. Acosta- IPN, Mexico City. Cota and A. Sánchez-López. Cinvestav-IPN, Mexico City. A27 1092.8 Testosterone induces activation of the extrinsic A16 1091.5 Effect of pentoxifylline and losartan on insulin- apoptotic pathway in VSMC by mechanisms involving ROS resistant equine digital vessels. C.S. Venugopal, E. Holmes, generation. R. Lopes, K. Neves, A. Chignalia, C. Zanotto, C. C. Koch, M. Kearney and S. Eades. LSU Sch. of Vet. Med. Pestana, C. Curti and R. Tostes. Univ. of São Paulo, Ribeirão A17 1091.6 Reduced nitric oxide–cGMP signaling Preto. contributes to vascular dysfunction induced by the adipokine T chemerin. K. Neves, N. Lobato, R. Lopes, C. Zanotto, F. 1093. GASTROINTESTINAL PHARMACOLOGY U Filgueira, A.M. Oliveira and R. Tostes. Univ. of São Paulo, E Ribeirão Preto. Poster A18 1091.7 The effect of nitric oxide on blockade of the norepinephrine transporter, uptake-1, by atomoxetine. J.A. Tue. 7:30 am—Boston Convention & Exhibition Center, Simaan. American Univ. of Beirut. Exhibit Halls A-B A19 1091.8 The oligomerized polyphenol oligonol Presentation time: 12:30 pm-2:30 pm ameliorates high glucose- and TNF-a-induced NADPH oxidase activation and insulin signaling downregulation in vascular A28 1093.1 The role of FcRn in monoclonal antibody serum endothelial cells. H. Yokoo, K. Taguchi and Y. Hattori. Univ. of uptake from the intestine in suckling rat pups. P.R. Cooper, C. Toyama, Japan. Kliwinski, R. Perkinson, J. Mabus, J. Giles-Komar and P. Hornby. Janssen R&D. Radnor, PA. A29 1093.2 Gastroprotective, ulcer healing and antioxidant activity of protoberberine alkaloid isolated from partially purified fraction of crude dichloromethane stem extract of coscinium fenestratum. P.N. Okechukwu, J. Marunga, N.C. Chiam, P.R. Godspower and G.A. Akowuah. Ucsi Univ., Malaysia.
371 PHARMACOLOGY TUESDAY
A30 1093.3 FcRn expression and antibody transcytosis in A44 1093.17 Losartan protection against CCL4-induced adult human and non-human primate intestine. P.J. Hornby, hepatic fibrosis involves changes in adhesion molecules and P.R. Cooper, C. Kliwinski, E. Ragwan, J.R. Mabus, B. inflammatory markers.N.N. Nassar, S.A. El Wakeel, M.I. El Harman, H. Dorai and J. Giles-Komar. Janssen R&D, Radnor, Sayed and E.S.M. El-Denshary. Fac. of Pharm., Cairo Univ., PA. Misr Intl. Univ. and Sinai Univ., Egypt. A31 1093.4 Bifidobacteria confer protection against A45 1093.18 Stable gastric pentadecapeptide BPC 157 for NSAID-enteropathy independently of acetate production. colitis and multiple sclerosis: healing of cysteamine-colitis and S.D. Syer, R. Martin, G.W. McKnight, P. Langella and J.L. colon-colon-anastomosis. P. Sikiric, R. Klicek, D. Kolenc, J. Wallace. McMaster Univ., Canada and MICALIS Inst. INRA, Suran, D. Drmic, L. Brcic, G. Aralica, S. Seiwerth and R. Jouy en Josas. Rucman. Med. Fac., Univ. of Zagreb, Croatia. A32 1093.5 Dihydrotanshinone induced apoptosis in colon A46 1093.19 TCP-1 as a novel phage-display peptide cancer cells by p53-independent but ROS dependent pathway targeting colon cancer. L. Lan and C.C. Hin. The Chinese Univ. mediated by mitochondria. L. Wang, J.H.K. Yeung, W.Y.W. Lee, of Hong Kong. X.L. Zhou, T. Hu and C.H. Cho. The Chinese Univ. of Hong A47 1093.20 Additive antiemetic efficacy ofD 9-THC with Kong. vanilloid TRPV1 receptor agonists in the least shrew (Cryptotis A33 1093.6 The human host defense peptide cathelicidin parva). R.S. Brar, S. Chebolu, W. Zhong and N.A. Darmani. induces AIFf- and EndoG-mediated cell death in colon cancer COMP, Western Univ., CA. cells. C.H. Cho and S.X. Ren. Sch. of Biol. Sci., The Chinese A48 1093.21 Both supraspinal and spinal mechanisms may Univ. of Hong Kong. be involved in the maintenance of gastric mucosal integrity in A34 1093.7 Cathelicidin is a host defense peptide in the rat. K. Gyires, V. Tóth, K. Király, I. Barna and Z.S. Zádori. controlling Helicobacter pylori survival and infection. L. Zhang, Semmelweis Univ. and Inst. of Exptl. Med., Budapest. J. Yu, W.K.K. Wu and C.H. Cho. The Chinese Univ. of Hong A49 1093.22 Antiviral activity of Bifidobacterium longum Kong and Prince of Wales Hosp., Hong Kong. SPM1205, 1206 and Lactobacillus ruminis SPM0211 against - A35 1093.8 Gender difference in duodenal HCO3 response rotavirus. J-Y. Kang, D-K. Lee, M-J. Kim, J-E. Park, H-S. Shin to mucosal acidification: importance of upregulation of ASIC3 and N-J. Ha. Col. of Pharm., Duksung Women’s Univ. and Col. by estradiol. K. Takeuchi, Y. Ohashi, K. Amagase and E. of Pharm., Sahmyook Univ., South Korea. Aihara. Kyoto Pharmaceut. Univ. A50 1093.23 Antiviral activity of Bifidobacterium adolescentis A36 1093.9 Role of calcium-sensing receptor on gastric SPM1605 against coxsackievirus B3. M.J. Kim, D.K. Lee, J.Y. acid secretion in isolated mouse stomachs. K. Takeuchi, S. Kang, J.E. Park and N.J. Ha. Sahmyook Univ. and DukSung Hayashi, K. Amagase and E. Aihara. Kyoto Pharmaceut. Women’s Univ., South Korea. Univ. A51 1093.24 Electrophysiological characterization of A37 1093.10 Mucosal protective agents prevent purinergic receptors in mouse enteric neuron-glia culture. A.R. exacerbation of NSAID-induced small intestinal lesions caused Gade and H.I. Akbarali. Virginia Commonwealth Univ. by antisecretory drugs in rats. H. Satoh, K. Amagase, A. Yokoi, A52 1093.25 Signaling pathways in control of gastric acid M. Ohashi, S. Kuwata, S. Mochizuki and K. Takeuchi. Kyoto secretion and food-stomach-bone axis revealed by gene Pharmaceut. Univ. expression profiling in the stomach of genetically targeted A38 1093.11 Cortricotropin-releasing factor (CRF) may mice deficient in CCK1 receptor and gastrin/CCK2 receptor. protect the gastric mucosa against injury through involvement D. Chen and C-M. Zhao. Norwegian Univ. of Sci. and Technol., CRF1 and CRF2 receptor types. L. Filaretova, O. Morozova, Trondheim. M. Myazina and T. Bagaeva. Pavlov Inst. of Physiol., St. A53 1093.26 Pentadecapeptide BPC 157 after 70% liver Petersburg, Russia. resection in rats. P. Sikiric, D. Crvenkovic, M. Sever, N. Lojo, A39 1093.12 Evidence of NSAID partitioning into splanchnic Z. Krstonijevic, D. Drmic, A. Zenko, L. Brcic, I. Zoricic, lymphatics: possible route to avoid first-pass hepatic Z. Rasic, R. Rucman and S. Seiwerth. Med. Fac., Univ. of metabolism. L.M. Lichtenberger, T. Phan and E. Dial. Univ of Zagreb, Croatia. Texas Hlth. Sci. Ctr. at Houston. A54 1093.27 R-type Ca2+ channels and inhibitory A40 1093.13 The effect of a hydrogen sulfide-releasing non- neuromuscular transmission in the gastrointestinal tract. E. steroidal anti-inflammatory drug on gastric and renal damage Rodriguez-Tapia and J. Galligan. Michigan State Univ. in streptozotocin-induced diabetic rats. M. Chan, R. Blackler, A55 1093.28 Macrophage infiltration and oxidative stress in W. McKnight and J. Wallace. McMaster Univ., Canada. rat ileum cause loss of nitrergic inhibitory neurons in DOCA- A41 1093.14 Bacterial stimulation of endogenous hydrogen salt hypertensive rats. L. Thang, D. Fried and J. Galligan. sulfide synthesis: a novel mechanism for resolution and repair Michigan State Univ. in the colon. K. Flannigan, E. Verdu and J. Wallace. McMaster A56 1093.29 Electrophysiological properties of colon- Univ., Canada. projecting sensory neurons in male and female serotonin A42 1093.15 Reversal of p-glycoprotein mediated multidrug transporter knockout rats. S. Schneider, H. Wang, D. Fried resistance by cryptotanshinone and dihydrotanshinone. T. Hu, and J. Galligan. Michigan State Univ. and Univ. of Michigan. J.H.K. Yeung, L. Wang, X. Zhou, P.M.Y. Or, K.K.W. To and C.H. A57 1093.30 Peripheral and central NK1 receptors in emesis Cho. Sch. of Biomed. Sci. and Sch. of Pharm., The Chinese control in Suncus murinus. J.A. Rudd, F.H.M. Cheng and B. Univ. of Hong Kong. Moreaux. Sch. of Biomed. Sci., Chinese Univ. of Hong Kong, A43 1093.16 The newer therapeutic alternatives to the Hong Kong and Johnson and Johnson R&D, Belgium. acid-oriented approach via targeting endothelial metabolism A58 1093.31 Transcription factor Egr-1 in molecular in esophagoprotection by 5-hydroxytryptamine and melatonin. mechanisms of experimental gastric ulcers. S. Beregoviy, V. O. Zayachkivska, M. Savytska, S. Mandrusyak and A. Kukharskyy, K. Bernyk, T. Beregova and G. Tolstanova. Yaschenko. Lviv Natl. Med. Univ., Ukraine. Taras Shevchenko Natl. Univ. of Kiev, Ukraine.
372 TUESDAY PHARMACOLOGY
A59 1093.32 Redox regulation of the KATP channel complex A70 1095.7 Regulation of the AGS4–Gai interaction by in colonic inflammation. M. Kang, A.R. Gade and H.I. Akbarali. chemokine receptors and the non-receptor guanine nucleotide Virginia Commonwealth Univ. exchange factor Ric-8A. W.G. Robichaux III, S.S. Oner, S.M. Lanier and J.B. Blumer. Med. Univ. of South Carolina. 1094. G PROTEINS A71 1095.8 RGS2 repression increases susceptibility of mice to interleukin-13-induced airway hyperresponsiveness. Y. Poster Xie, H. Jiang, P.W. Abel, T.B. Casale, R.A. Panettieri and Y. Tu. Creighton Univ. and Univ. of Pennsylvania. Tue. 7:30 am—Boston Convention & Exhibition Center, A72 1095.9 Structural studies of RGS inhibitors. C.A. Exhibit Halls A-B Higgins, E. Fuentes and D. Roman. Univ. of Iowa and Univ. of
Presentation time: 12:30 pm-2:30 pm Iowa Hosps. and Clins. A73 1095.10 Neuroadaptations in D2-like autoreceptor A60 1094.1 Constitutive activity of Gs a R201H is function following AMPH self-administration. E.S. Calipari, H. suppressed by disruption of either of two hydrophobic pockets Sun, S.R. Jones and R. Chen. Wake Forest Sch. of Med. within the protein. R. Pals-Rylaarsdam, K. Turcic, J. Carroll, A74 1095.11 Dynamic control of allosteric inhibitor specificity R. Tobar-Rubin, D. Janevska, E. Din, R. Alvarez and F. for RGS4. A.J. Storaska, H. Vashitsh and R.R. Neubig. Univ. Choudhry. Benedictine Univ., IL. of Michigan. A61 1094.2 The mechanism of the Ric-8 protein A75 1095.12 Regulator of G-protein signaling 5 reduces requirement in heterotrimeric G protein biosynthesis. P.Y. Chan HeyA8 ovarian cancer cell proliferation and extends survival in and G. Tall. Univ. of Rochester. a murine tumor model. M.K. Altman, A. Beedle and M. Murph. A62 1094.3 Identification of a novel activator of GOA- Univ. of Georgia. 1, a trimeric G protein critical for early stages of C. elegans A76 1095.13 Modulation of regulator of G-protein signaling development. B.D. Coleman, L.T. Nguyen and M. Garcia- 4 activity by covalent modification of 4hydroxy-2-nonenal. C.A. Marcos. Boston Univ. Sch. of Med. and Boston Univ. Monroy and D. Roman. Univ. of Iowa. A63 1094.4 Activation of the G(s) heterotrimer monitored in living cells with novel G(s) biosensors. H. Yano, D. Provasi, 1096. GPCR CELLULAR SIGNALING AND M. Filizola, S. Ferre and J.A. Javitch. Columbia Univ., NIDA, PHYSIOLOGY NIH, Baltimore and Mount Sinai Sch. of Med. Poster 1095. RGS/AGS PROTEINS Tue. 7:30 am—Boston Convention & Exhibition Center, Poster Exhibit Halls A-B
Tue. 7:30 am—Boston Convention & Exhibition Center, Presentation time: 12:30 pm-2:30 pm Exhibit Halls A-B A77 1096.1 Non-canonical MMP1-PAR1 signaling drives Presentation time: 12:30 pm-2:30 pm vascular smooth muscle cell de-differentiation and restenosis. K. Austin, G. Javid and A. Kuliopulos. Sackler Sch. of A64 1095.1 Transcriptional suppression, DNA methylation, Biomed. Sci., Tufts Univ. and Tufts Med. Ctr. and histone deacetylation of the regulator of G-protein signaling A78 1096.2 Role of kallikrein 6-mediated PAR signaling 10 (RGS10) gene in ovarian cancer cells. M.W. Ali, E. Cacan, Y. in astrogliosis. M. Radulovic, H. Yoon, A. Vandell and I. Liu, S.T. Eblen, S.F. Greer and S.B. Hooks. Univ. of Georgia, Scarisbrick. Mayo Clin. Georgia State Univ. and Med. Univ. of South Carolina. A79 1096.3 Induction of CXCR7 switches SDF-1 signaling A65 1095.2 GPR158 and GPR179: a subfamily of orphan and phagocytic function in macrophages: a potential role in GPCRs as a new class of G protein signaling modulators. C. atherosclerosis. W. Ma, Y. Liu, N. Ellison and J. Shen. Auburn T Orlandi, I. Masuho, E. Posokhova, Y. Cao, T. Ray, N. Hasan, Univ. R. Gregg and K. Martemyanov. The Scripps Res. Inst., Jupiter, A80 1096.4 GPR124 coupling and function in astrocytomas. U FL and Univ. of Louisville. A. Cherry, Y.H. Lin, C. Hague, S-E. Ong and N. Stella. Univ. of E A66 1095.3 RGS 2 and RGS 4 differentially modulate G Washington. protein coupled receptor signaling in the mouse aorta. N.W. A81 1096.5 G-protein coupled receptor profiling: an omics Mabe, S. Seeley, L. Fehrman, P. Garber, R.R. Neubig and approach to study receptors and cell signaling. A.S. Wilderman, B.R. Rorabaugh. Ohio Northern Univ. Col. of Pharm. and Univ. A. Snead, F. Murray, N. Aroonsakool and P.A. Insel. UCSD. of Michigan Med. Sch. A82 1096.6 Repeated cannabinoid administration induces A67 1095.4 Activator of G protein signaling-3 regulates DFosB and sensitizes mu opioid receptor activity in the nucleus CXCR4 and CCR7 signaling in murine lymphocytes and bone accumbens. L. Sim-Selley, M. Lazenka, E. Nestler and D. marrow-derived dendritic cells. M. Branham-O’Connor, W.G. Selley. Virginia Commonwealth Univ. and Mount Sinai Sch. of Robichaux III, E.M. Maher, X. Zhang and J.B. Blumer. Med. Med. Univ. of South Carolina. A83 1096.7 Receptor mediated signaling by A68 1095.5 RGS2 protein degradation is mediated by a lysophosphatidic acid and epidermal growth factor in a colon novel multiprotein E3 ligase containing Cullin 4b and F box 44. cancer cell line. A.K. Bell, Z. Zhang and K. Meier. Washington B. Sjogren, S. Swaney and R. Neubig. Univ. of Michigan. State Univ. A69 1095.6 RGS2 regulates urotensin II-induced A84 1096.8 Modification of sterol composition in yeast cell 2+ intracellular Ca elevation and contraction in glomerular membrane from ergosterol to cholesterol and its effect on Ste2 mesangial cells. A. Adebiyi. Univ. of Tennessee, Memphis. signaling. K. Kuroda, S. Morioka, T. Shigemori, K. Hara, H. Morisaska and M. Ueda. Grad. Sch. of Agr., Kyoto Univ.
373 PHARMACOLOGY TUESDAY
A85 1096.9 Lipopolysaccharide-induced upregulation A98 1097.4 Effect of cannabinoid CB2 receptor agonism of cannabinoid 2 receptors in rat cortical astrocytes. D.N. on learning and memory in a mouse model of photothrombosis. Jackson and A. Shivachar. Col. of Pharm. and Hlth. Sci., A.M. Myers, R.D. Ronca, E.A. Walker, R.F. Tuma and S.J. Texas Southern Univ. Ward. Temple Univ. A86 1096.10 PKCe-mediated P-Rex1 downregulation A99 1097.5 In search of endocannabinoid degradation suppresses breast cancer cell proliferation. C-Y.A. Wong, Y. enzymes inhibitors in nutmeg. A.T. El-Alfy, S. Joseph and A. Xie, D.W. Wolff, P.W. Abel and Y. Tu. Creighton Univ. Sch. of Brahmbhatt. Chicago State Univ. Med. A100 1097.6 Discriminative stimulus effects of the synthetic A87 1096.11 CB1 cannabinoid receptors signal through cannabinoid JWH-018 in rhesus monkeys. J.S. Rodriguez and focal adhesion kinase to activate ERK in neuronal cells. G.D. L.R. McMahon. Univ. of Texas Hlth. Sci. Ctr. at San Antonio. Dalton and A.C. Howlett. Wake Forest Sch. of Med. A101 1097.7 Inhibition of both FAAH and MAGL, but not A88 1096.12 Effect of D3 dopamine receptor signaling either separately, produces delta-9-THC like discriminative properties on rodent locomotion. S.R. Cote, Y. Li and E. stimulus effects. L. Hruba, M.J. Niphakis, B.F. Cravatt, A.H. Kuzhikandathil. Univ. of Med. and Dent. of New Jersey, Lichtman and L.R. McMahon. Univ. of Texas Hlth. Sci. Ctr. at Newark. San Antonio, The Scripps Res. Inst. and Virginia Commonwealth A89 1096.13 Astrocytes produce nitric oxide in response to Univ. cholinergic or glutamatergic stimulation. X. Wang, A. Lessard, A102 1097.8 A behavioral assessment of the aversive L-E. Trudeau and H. Girouard. Univ. of Montreal and Univ. of properties of delta-9-THC in Fischer-Lewis rats. A. Presley Maryland Baltimore. and A. Riley. American Univ.
A90 1096.14 Initial characterization of histamine H2-receptor A103 1097.9 Cannabidiol attenuates the long lasting overexpressing mice. J. Neumann, F. Köhler, U. Kirchhefer, A. cognitive deficits and anxiogenic-like behaviors promoted by Höft, I. Buchwalow and U. Gergs. Martin Luther Univ. Halle- murine cerebral malaria. A.C. Campos, A.S. Miranda, F. Brant, Wittenberg, Inst. for Pharmacol. and Toxicol., Münster and N.P. Rocha, F.S. Machado, M.A. Rachid, F.S. Guimarães Hematopathol. Inst., Hamburg, Germany. and A.L. Teixeira. Fed. Univ. of Minas Gerais, Sch. of Med. of A91 1096.15 Evidence that the a1L-adrenoceptor is the Ribeirão Preto and Univ. of São Paulo. native a1A-adrenoceptor in rat vas deferens. J.R. Docherty. A104 1097.10 Effects of anandamide and other CB1 ligands Royal Col. Surgeons Ireland. on cognitive function. B.D. Kangas and J. Bergman. Harvard A92 1096.16 Neuroblastoma cell proliferation involves Med. Sch./McLean Hosp. prostaglandin E2 and subsequent b-catenin stabilization. S. Jansen, J. Van Oppen, I. Hedemann, R. Holman, S. Faraj, 1098. STIMULANTS II J.W. Kok, S. Diks, W. Timens, R. Gosens, E. De Bont and M. Schmidt. Univ. of Groningen and Univ. Med. Ctr. Groningen. Poster A93 1096.17 The 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. O. Tue. 7:30 am—Boston Convention & Exhibition Center, Lin, E.V.P. Espinosa and F.T. Khasawneh. Western Univ. of Exhibit Halls A-B
Hlth. Sci. Presentation time: 12:30 pm-2:30 pm A94 1096.18 Activation of G protein-coupled estrogen receptor 1 induced coronary vasodilation by activation of MLCP A105 1098.1 The effects of tropisetron on cocaine-induced via cAMP/PKA pathway. X. Yu, F. Li, R.E. White, J.N. Stallone, conditioned taste aversions. M. Briscione, K. Serafine, C.L. Heaps and G. Han. Texas A&M Univ. and Philadelphia A. Merluzzi, K. Rice and A. Riley. American Univ., Univ. of Col. of Osteo. Med., Suwanee, GA. Texas Hlth. Sci. Ctr. at San Antonio and NIDA and NIAAA, NIH, Baltimore. 1097. CANNABINOIDS A106 1098.2 Stereoselective effects of methcathinone on intracranial self-stimulation in rats. J.S. Bonano, M.L. Banks, Poster R.A. Glennon and S.S. Negus. Virginia Commonwealth Univ. A107 1098.3 Attenuation of cocaine-induced behaviors by Tue. 7:30 am—Boston Convention & Exhibition Center, the sigma receptor ligand YZ-185. A.S. Sage, K-H. Fan, J.R. Exhibit Halls A-B Lever, S.Z. Lever and D.K. Miller. Univ. of Missouri-Columbia. A108 1098.4 Effects of chronic amphetamine treatment Presentation time: 12:30 pm-2:30 pm on cocaine-induced facilitation of intracranial self-stimulation A95 1097.1 Tolerance and cross-tolerance among high- in rats. C.T. Bauer, M.L. Banks and S.S. Negus. Virginia efficacy synthetic cannabinoids JWH-018 and JWH-073 and Commonwealth Univ. Sch. of Med. low-efficacy phytocannabinoidD 9-THC. W.E. Fantegrossi, L.N. A109 1098.5 Loss of sensitivity to varenicline in monkeys Franks, T. Vasiljevik and P.L. Prather. Univ. of Arkansas for receiving chronic nicotine treatment. C.S. Cunningham and Med. Sci. and Univ. of Kansas. L.R. McMahon. Univ. of Texas Hlth. Sci. Ctr. at San Antonio. A96 1097.2 Possible efficacy related differences among A110 1098.6 Punishment by intravenous nicotine in rats. cannabinoid agonists. G. Chopda, J. Bergman, K. Vemuri, Y.N-T. Truong and J. Woods. Univ. of Michigan. A. Makriyannis and C.A. Paronis. Northeastern Univ. and A111 1098.7 Physical dependence liability of nicotine in McLean Hosp./Harvard Med. Sch. mice—possible involvement of endogenous opioid system A97 1097.3 Interactions between mu opioid receptor located on the downstream of a 7 nicotinic acetylcholine agonists and cannabinoid receptor agonists CP55940 and receptor. S. Kishioka, N. Kiguchi, Y. Kobayashi, N. Wakida WIN55212-2 in rhesus monkeys: evaluation of treatment- and and C. Yamamoto. Wakayama Med. Univ., Japan. abuse-related effects. D.R. Maguire, W. Yang and C.P. France. Univ. of Texas Hlth. Sci. Ctr. at San Antonio.
374 TUESDAY PHARMACOLOGY
A112 1098.8 Anatabine significantly decreases nicotine A125 1099.3 Optogenetic and pharmacological activation of self-administration. N.K. Mello, P.A. Fivel, S.J. Kohut and S.B. beta-adrenergic receptor signaling in the basolateral amygdala Caine. McLean Hosp., Harvard Med. Sch. promotes anxiety and aversive behavior. E.R. Siuda, R. Al- A113 1098.9 Further characterization of varenicline and Hasani, J.G. McCall, S.D. Chang, S.L. Anderson and M.R. mecamylamine and effects on self-administration of cocaine Bruchas. Washington Univ. in St. Louis. and nicotine. S.A. Kromrey, S. Nader and M. Nader. Wake A126 1099.4 An investigation of metabotropic glutamate Forest Sch. of Med. receptor 5 negative allosteric modulators in physiological A114 1098.10 Discriminative-stimulus effects of and behavioral indicators of anxiety and cognition in rodents. 3,4-methylenedioxy-N-methylamphetamine (MDMA) and a J. Moon, D. McGinnis, D.L. Smith, R. Graf, Z. Hughes, S. novel MDMA quatenary analog. J.M. Slezak, M. Mueller, G.A. Grimwood, E. Miller, P. Trapa, C.L. Shaffer and C.J. Siok. Ricaurte, J. Cao, A.H. Newman and J.L. Katz. NIDA, NIH, Pfizer Inc., Cambridge, MA. Baltimore and Johns Hopkins Sch. of Med. A127 1099.5 Anti-neuroinflammation and antidepressant A115 1098.11 Cocaine-induced locomotor activity in rats effects of Schisandrin B in mice. C-H. Yeh, M-W. Lin and H-C. selectively-bred for high and low motivation to voluntarily Lin. Chang Jung Christian Univ., Kaohsiung Chang Gung run. J.D. Brown, C. Green, D. Miller and F. Booth. Univ. of Mem. Hosp. and Natl. Yang-Ming Univ., Taiwan. Missouri-Columbia. A128 1099.6 Melatonin accelerates the re-entrainment A116 1098.12 Effects of two-week chronic treatment with rate of multiple spontaneous homecage behavioral rhythms phendimetrazine on choice between cocaine and food in in the C3H/HeN mice. E.B. Adamah-Biassi, I. Stepien, R.L. rhesus monkeys. M.L. Banks, B.E. Blough and S.S. Negus. Hudson and M.L. Dubocovich. Univ. at Buffalo Sch. of Med. Virginia Commonwealth Univ. and Res. Triangle Inst. and Biomed. Sci. A117 1098.13 A comparison of the subjective and cardiovascular effects produced by exposure to intravenous 1100. NEUROPSYCHIATRIC DISORDERS versus smoked methamphetamine in the laboratory. J.J. Mahoney, C. Haile, T. Newton, B. Shapiro and R. De La Poster Garza. Baylor Col. of Med. A118 1098.14 Modulation of the discriminative-stimulus Tue. 7:30 am—Boston Convention & Exhibition Center, effects of cocaine by dopamine b-hydroxlyase inhibitors in rats. Exhibit Halls A-B D.F. Manvich, L. DeBrouse and D. Weinshenker. Emory Univ. Presentation time: 12:30 pm-2:30 pm A119 1098.15 Behavioral effects of quinpirole on schedule- controlled responding in radiation sensitive and insensitive rats. 7:30 AMA129 1100.1 Uncovering interactions between C.M. Davis and R.D. Hienz. Johns Hopkins Univ. Sch. of Med. organic cation transporters and monamine systems: A120 1098.16 Discriminative stimulus effects of direct- and implications for novel antidepressant therapies. D.M. Apple, indirect-acting dopamine receptor agonists in free-feeding and R.E. Horton, M. Vitela, W. Koek and L.C. Daws. Univ. of Texas food-restricted mice. G.T. Collins, J.A. Jackson, C. Henson, Hlth. Sci. Ctr. at San Antonio. W. Koek and C.P. France. Univ. of Texas Hlth. Sci. Ctr. at San 7:31 AMA130 1100.2 The tryptophan hydroxylase 2 Antonio. polymorphism C2432T mediates mRNA expression and A121 1098.17 Differential expression of MDPV-induced responses to antidepressant treatment in a sex-specific taste aversions and thermoregulation in adolescent and adult manner. B.R. Brookshire and I. Lucki. Univ. of Pennsylvania rats. A.P. Merluzzi, Z. Hurwitz, M. Briscione, J. Cobuzzi, B. Sch. of Med. Wetzell, K. Rice and A. Riley. American Univ. and NIDA, NIH. 7:32 AMA131 1100.3 Reduction in peripheral blood beta A122 1098.18 Eating high fat chow selectively impacts arrestin1 levels during major depressive disorder in reproductive sensitivity to drugs acting on dopamine D3/D2 but not serotonin women. T. Nayyar, F. Alam, W. Richie, T.A. Ansah and R.K. 2A receptors. K.M. Serafine and C.P. France. Univ. of Texas Bailey. Meharry Med. Col. Hlth. Sci. Ctr. at San Antonio. 7:33 AMA132 1100.4 Effects of duloxetine in rats trained to discriminate between 22 and 2 hours food deprivation. M.A. T U 1099. MOOD DISORDERS Vanden Avond, A.R. Johnson, K.A. Reed, M.M. Savickas, D.J. Nemec, A.T. Schultz, E.J. Hendrickson, N.K. Takle, C.A. E Poster Toddes, A.L. Lucas, B.N. Shattuck, A.P. Halverson, T.J. Vossen and D.C. Jewett. Univ. of Wisconsin-Eau Claire. Tue. 7:30 am—Boston Convention & Exhibition Center, 7:34 AMA133 1100.5 Age-related changes in anxiety- Exhibit Halls A-B like behavior modified by expression of a4 subunit containing nicotinic acetylcholine receptors. S. Anderson and D. Brunzell. Presentation time: 12:30 pm-2:30 pm Virginia Commonwealth Univ. A123 1099.1 Unraveling mechanisms contributing to lack 7:35 AMA134 1100.6 High levels of serotonin modulate of antidepressant efficacy in juveniles and adolescents. N.C. oxidative balance in brain’s area related with anxiety behavior? Mitchell, R.E. Horton, M. Vitela, G.G. Gould, W. Koek and A.I. da Silva, C. Freitas, L. Nascimento, L.C.M. Galindo, R. L.C. Daws. Univ. of Texas Hlth. Sci. Ctr. at San Antonio. Manhaes-de-Castro, C. Lagranha and S.L. de Souza. Fed. A124 1099.2 The role of hippocampal a2-containing GABAA Univ. of Pernambuco, Recife and Vitoria de Santo Antão, Brazil. receptors in benzodiazepine-induced anxiolysis. E. Engin, K.S. 7:36 AMA135 1100.7 Role of oxidative stress in anxiety- Smith, R. Keist, F. Crestani, J-M. Fritschy and U. Rudolph. like behavior and learning and memory impairment in a rat Harvard Med. Sch./McLean Hosp. and Univ. of Zurich. model of social stress. G. Patki, F. Allam, R. Bohat, F. Jafri, M. Saleem and S. Salim. Univ. of Houston.
375 PHARMACOLOGY TUESDAY
7:37 AMA136 1100.8 Chronic administration of the A146 1102.3 Induction of CYP2D6 expression during antipsychotic olanzapine dose-dependently enhances pregnancy is associated with an increased activity of hepatocyte sleep phenotypes in a rat model of metabolic syndrome. S. nuclear factor 4a. X. Pan, K. Koh, A-M. Yu and H. Jeong. Univ. Radzikowski, B.P. Shortal, C.J. Watson, L.G. Koch, S.L. of Illinois at Chicago and Univ. at Buffalo SUNY. Britton and H.A. Baghdoyan. Univ. of Michigan. A147 1102.4 Induction of cytochrome P450 2E1 expression 7:38 AMA137 1100.9 Simultaneous, in vivo monitoring by placental lactogen. J.K. Lee, H.J. Chung, X. Pan, M. of 10 neurotransmitters in rat prelimbic cortex reveals that Ingelman-Sundberg and H. Jeong. Univ. of Illinois at Chicago systemic and local administration of the atypical antipsychotic and Karolinska Inst. olanzapine differentially altered only serotonin levels. C.C. A148 1102.5 Aryl hydrocarbon receptor-dependence of Norton, O.S. Mabrouk, A. Shatsman, S. Radzikowski, R.T. dioxin effects on constitutive mouse hepatic cytochromes P450 Kennedy and H.A. Baghdoyan. Univ. of Michigan. and growth hormone signaling components. D.S. Riddick and 7:39 AMA138 1100.10 Neuropeptide Y infusion attenuates C. Lee. Univ. of Toronto. development of PTSD-like symptoms to traumatic stress in A149 1102.6 The role of cytochrome P450-dependent rats. L. Serova, A. Tillinger, L.G. Alaluf, M. Laukova and E.L. metabolism in the regulation of mouse hepatic growth Sabban. New York Med. Col. hormone signaling components and target genes by 3-methylcholanthrene. D.S. Riddick, C. Lee and X. Ding. Univ. 1101. CLINICAL PHARMACOLOGY of Toronto and New York State Dept. of Hlth., Albany. A150 1102.7 Long noncoding RNAs and transcription of Poster cytochrome P450s in mouse liver during maturation. L. Peng, A. Paulson, H. Li, X. He, H. Lu, C.D. Klaassen, L. Li and Tue. 7:30 am—Boston Convention & Exhibition Center, X-b. Zhong. Univ. of Connecticut, Univ. of Kansas Med. Ctr., Exhibit Halls A-B Stowers Inst. for Med. Res., MO and SUNY Upstate Med. Univ.
Presentation time: 12:30 pm-2:30 pm A151 1102.8 17b-Estradiol (E2) induces sulfotransferase 2A1 expression through estrogen receptor a. W. Li, M. Ning, H. A139 1101.1 Lost in translation—challenges for academic Kim and H. Jeong. Univ. of Illinois at Chicago and Yangzhou scientists in writing clinical protocols. E.M. Seymour, J. Univ., China. Wright, M. Moore, B. Reisdorph and K. Weatherwax. Univ. of A152 1102.9 Functional analysis of splice variants of human Michigan. constitutive androstane receptor: investigation with flavonol A140 1101.2 Effect of azelnidipine in human internal (3-hydroxyflavone) and its metabolites. A.J. Lau and T.K.H. mammary artery and clinical implications. G. Gao, X-Y. Bai, C. Chang. Univ. of British Columbia. Xuan, X-C. Liu, W-B. Jing, Q. Yang and G-W. He. TEDA Intl. Cardiovasc. Hosp., Med. Col., Nankai Univ., The Chinese Univ. 1103. PHARMACOKINETICS/PHARMACODYNAMICS of Hong Kong and Oregon Hlth. & Sci. Univ. A141 1101.3 The occurrence and management of pediatric Poster poisonings in Lenasia, South Africa. A.Y. Ahmed and S. Moch. Univ. of Witwatersrand, South Africa. Tue. 7:30 am—Boston Convention & Exhibition Center, A142 1101.4 Effect of cilostazol on patients with intermittent Exhibit Halls A-B claudication: role of endothelial progenitor cells. T. Tejerina, M. Presentation time: 12:30 pm-2:30 pm Ramajo, J. Navarro-Dorado, U. Medina, M.H. Rydings, M. Perera, E. Puras, F.J. Serrano-Hernando and S. Redondo. A153 1103.1 P-glycoprotein (ABCB1) and breast cancer Sch. of Med., Complutense Univ. of Madrid, Clin. Hosp. San resistance protein (ABCG2) restrict the brain penetration of Carlos and Alcorcon Fndn. Hosp., Madrid. the Janus family of tyrosine kinase (JAK) inhibitor CYT387. S. A143 1101.5 Prescription analysis for patients with upper Durmus, N. Xu, R.W. Sparidans, E. Wagenaar, J.H. Beijnen respiratory tract infections at tertiary referral center in Anand. and A.H. Schinkel. Netherlands Cancer Inst., Amsterdam, K.J. Patel, A. Leuva and A. Rangoonwala. Ramanbhai Patel China-Japan Union Hosp., Changchun, China, Utrecht Univ. Col. of Pharm. and Pramukh Swami Med. Col., India. Fac. of Sci. and Slotervaart Hosp., Netherlands. A154 1103.2 Human pharmacokinetics of xanthohumol, a 1102. TRANSCRIPTIONAL REGULATION OF DRUG flavonoid from hops with anti-diabetic activity. L. Legette, R. METABOLISM Reed, C. Miranda, C. Karnpracha, J.M. Christensen and J.F. Stevens. Col. of Pharm., Oregon State Univ. Poster A155 1103.3 A novel method to estimate AF-219 levels in bladder interstitium derived from drug excreted into the Tue. 7:30 am—Boston Convention & Exhibition Center, urine. S.A. Smith, D. Black, D. Song and A.P. Ford. Afferent Exhibit Halls A-B Pharmaceuts., San Mateo, CARE Res., Fort Collins and PPL Lab., Redwood City. Presentation time: 12:30 pm-2:30 pm A156 1103.4 Assessing drug interaction risk of the A144 1102.1 Transcriptional regulation of human UDP- grapefruit juice component and dietary supplement glucuronosyltransferase 2B4 by sulfotransferase deficiency. K. 6’,7’-dihydroxybergamottin via physiologically-based Barrett, H. Fang, T.A. Kocarek and M. Runge-Morris. Wayne pharmacokinetic modeling and simulation. G.R. Ainslie, B.T. State Univ. Gufford, C.S. Won, K.K. Wolf and M.F. Paine. Eshelman Sch. A145 1102.2 Functional association of hepatocyte nuclear of Pharm., Univ. of North Carolina at Chapel Hill. factor 4 alpha and Krüppel-like factor 9 in cytochrome P450 2D6 regulation during pregnancy. K.H. Koh, X. Pan, A. Yu and H. Jeong. Col. of Pharm., Univ. of Illinois at Chicago and Univ. at Buffalo SUNY. 376 TUESDAY PHARMACOLOGY
A157 1103.5 Comparative pharmacokinetics of the A168 1104.9 Purinergic mechanisms in breast cancer complement inhibitor CDX-1135. E. Forsberg, J.M. Boyer, development: a role for nucleoside diphosphate kinase. S. L.E. Gergel, C.D. Pilsmaker, K.M. Borrelli, S.M. Round, S.R. Wong, N. Yokdang, K. Speirs and I.L.O. Buxton. Univ. of Naylor, H.C. Marsh, Jr., T. Keler and L.J. Thomas. Celldex Nevada, Reno. Therapeut., Needham, MA and Phillipsburg, NJ. A158 1103.6 Evaluation of oral dabigatran etexilate 1105. CANCER THERAPEUTICS pharmacokinetics and pharmacodynamics in hemodialysis patients. K. Goralski, M. Morrison, P. Mossop, S. Soroka, Poster D. Anderson and J-A. Wilson. Col. of Pharm., Dalhousie Univ. and Hlth. Sci. Ctr., Capital District Hlth. Authority, Halifax, Tue. 7:30 am—Boston Convention & Exhibition Center, Canada. Exhibit Halls A-B
A159 1103.7 Contrasting pharmacodynamic requirements Presentation time: 12:30 pm-2:30 pm of disease models revealed through characterization of a novel and selective M1 agonist. M. Wood, G. Martino, M. Coupal, A169 1105.1 Modulated light wave tumor therapy: case M. Lindberg, P. Schroeder, V. Santhakumar, M. Valiquette, J. study. O.L. Tulp, G.P. Einstein, T. Chow, M.P. Wnuk and R. Sandin, D. Widzowski and J. Laird. AZ Neurosci., Cambridge, Branly. USAT Col. of Med., Montserrat and Univ of Wisconsin- MA. Milwaukee. A170 1105.2 Rock inhibition reduces senescent cell size. 1104. CANCER PREVENTION Y.D. Simay, S. Hosbas, B. Ibisoglu, M. Yildiz, A. Ozdemir and M. Ark. Gazi Univ., Turkey. Poster A171 1105.3 Apoptotic mechanism of novel anticancer agents is mediated by MAPKs in breast cancer cells. L.S. Tue. 7:30 am—Boston Convention & Exhibition Center, McLean and E. Brantley. Loma Linda Univ. Exhibit Halls A-B A172 1105.4 Oncolytic adenoviral therapy enhanced by targeting cyclin E overexpression and inducing autophagy. P-h. Presentation time: 12:30 pm-2:30 pm Cheng, X-M. Rao, K.M. McMasters and H.S. Zhou. Univ. of A160 1104.1 Soluble epoxide hydrolase deficiency inhibits Louisville. DSS-induced colitis and carcinogenesis in mice. W. Zhang, A173 1105.5 Alterations in the intracellular Ca2+ H. Li, H. Dong, J. Liao, B.D. Hammock and G-Y. Yang. concentration and vimentin in endothelial cells following tumor Northwestern Univ., Chicago and Univ. of California, Davis. cell-endothelial cell interactions. Y. Pan and X. Li. Peking Univ. A161 1104.2 Curcumin and turmeric as preventive agents A174 1105.6 A new strategy to block tumor angiogenesis for iron-related carcinogenesis. D.J. Messner, T. Robinson by inhibiting endocannabinoid inactivation. M. El-Azab, R. and K.V. Kowdley. Bastyr Univ. and Benaroya Res. Inst. at Ammar, M. Abdel-Hamid and Y. Moustafa. Suez Canal Univ., Virginia Mason Hosp., Seattle. Sinai Univ. and Al-Azhar Univ., Egypt. A162 1104.3 Chemopreventive role of metformin during A175 1105.7 Withdrawn. DMBA–induced breast carcinogenesis inMCF10A cells through A176 1105.8 The role of 20-HETE in the regulation of CYP1A1-AhR signaling pathway. Z.H. Maayah, A.A. AlHaider androgen receptor nuclear translocation. Y. Liu, K. Gotlinger and H.M. Korashy. King Saud Univ., Saudi Arabia. and M. Schwartzman. New York Med. Col. A163 1104.4 The preventive and therapeutic efficacy of A177 1105.9 Crude extracts of Antrodia cinnamomea inhibit finasteride and dutasteride in TRAMP mice.A.B. Opoku- invasion and migration of human hepatocellular carcinoma Acheampong, D. Unis, A.P. Beck, J. Henningson and B.L. cells. Y-Y. Chen and M-J. Sheu. China Med. Univ., Taiwan. Lindshield. Kansas State Univ. and Yale Univ. Sch. of Med. A178 1105.10 Celecoxib induces apoptosis by the intrinsic A164 1104.5 miR-627 mediates the epigenetic mechanism pathway in HT-29 colon carcinoma and A375 melanoma cells. of vitamin D in suppression of colon cancer growth both in vitro R.A. Schneider, K.G. Eckles, V.C. Kelty, L.R. Palmisano, K.A. and in vivo. S. Padi and B. Guo. North Dakota State Univ. Strozewski, J.S. Teckmeyer and D.H. Kinder. Col. of Pharm., T A165 1104.6 Pterostilbene inhibits VEGF production in Univ. of Findlay and Col. of Pharm., Ohio Northern Univ. U human breast cancer [MDA-MB-231] cells. A. Sanghani, T. A179 1105.11 Epinephrine stimulates secretion of VEGF E Kandra, S. Bavadekar and S. Vansal. Long Island Univ. and by human prostate cancer cells, LNCaP, through a beta2- Touro Col. of Pharm., NY. adrenergic receptor-mediated pathway. S. Bavadekar, F. A166 1104.7 Alterations in benzo(a)pyrene induced DNA Budajaja, K. Patel and S. Vansal. Arnold & Marie Schwartz damage via organosulfide compounds in MCF-10A cells. Col. of Pharm. and Hlth. Sci., Long Island Univ. and Touro Col. S.F. Darling-Reed, Y. Nkrumah-Elie, A. Hudson, H. Flores- of Pharm., New York. Rozas, M. Jett, R. Hammamieh, A. Day, E. Oriaku and J.S. A180 1105.12 Allicin inhibits metastasis of MCF-7 cells by Reuben. Florida A&M Univ., Oregan State Univ., WRAIR, Ft. inhibition of VCAM-1 expression. C.G. Lee and S. Pyo. Sch. of Detrick, Howard Univ and Univ. of South Carolina Sch. of Med. Pharm., Sungkeunkwan Univ., South Korea. A167 1104.8 GUCY2C hormone deficiency contributes A181 1105.13 Small molecule targeting of RhoC-regulated to diet-induced colorectal tumorigenesis. J.E. Lin, F. Colon- gene transcription in metastatic, undifferentiated melanoma. Gonzalez, G.W. Kim, P. Li, E.S. Blomain, G. Marszalowicz, A.J. Haak, S.M. Wade, J.L. Bell, S.D. Larsen, M. Verhaegen, B.A. Stoecker and S.A. Waldman. Thomas Jefferson Univ., E.R. Lawlor and R.R. Neubig. Univ. of Michigan. Univ. of Utah and Drexel Univ. A182 1105.14 The ameliorative effect of silymarin on cadmium-treated human lung carcinoma cells. C.A. Webster, L.M. Latinwo, V.L.D. Badisa, C.O. Odewumi and S.F. Darling- Reed. Florida A&M Univ.
377 PHARMACOLOGY TUESDAY
A183 1105.15 Cytoskeletal inhibitor disruption of tunneling A198 1105.30 Selective growth inhibition of human malignant nanotube mediated communication may affect cancer melanoma cells by syringic acid-derived proteasome inhibitors. progression. Y.D. Connor, S. Bhatia, N.K. Gill, S. Tekleab, D. M-S.I. Abaza, K. Orabi, K. El Sayed, A. Elnagar, R. Al-Attiyah Bharat and S. Sengupta. Harvard-MIT, Cambridge, Smith Col. and R. Guleri. Kuwait Univ., Univ. of Louisiana at Monroe and and Brigham and Women’s Hosp. Univ. of Southern California. A184 1105.16 Growth inhibition and radiosensitization of human papillomavirus positive head and neck cancer by 1106. HEPATOTOXICITY epidermal growth factor receptor inhibition is mediated by apoptosis. R.J. Kimple, M.A. Smith, G.C. Blitzer, H-S. Huang Poster and A.D. Torres. Univ. of Wisconsin-Madison. A185 1105.17 Selective estrogen receptor modulators Tue. 7:30 am—Boston Convention & Exhibition Center, resveratrol, genistein, tamoxifen and pterostilbene downregulate Exhibit Halls A-B
the expression of estrogen-regulated trefoil factor 1 gene in Presentation time: 12:30 pm-2:30 pm MCF-7 breast cancer cells. V.D. Bhatt and W.N. Ratna. Arnold & Marie Schwartz Col. of Pharm., Long Island Univ. A199 1106.1 Secreted factors of Lactobacillus rhamnosus A186 1105.18 Induction of apoptosis in MCF-7 and NCI/ GG culture prevents chronic alcohol-induced liver injury. Y. ADR-RES cells by triazole-containing estradiol analogs. R.A. Wang, C. Wang, C. Wang, M. Zhang, Y. Liu, C. McClain and Schneider, L.N. Reiff and R.W. Dudley. Univ. of Findlay, OH. W. Feng. Univ. of Louisville and Louisville VA Med. Ctr. A187 1105.19 Bioenergetic immunostimulation, metabolism, A200 1106.2 S-adenosyl-L-methionine (SAMe) protects and nutrition support in lung cancer: a case study. O.L. Tulp, the liver from acetaminophen (APAP) protein modifications G.P. Einstein, J. Kowaleski and M. Dancewicz. USAT- due to oxidative stress. A.B. Lamyaithong, J.M. Brown, J.G. Montserrat, and Nicolaus Copernicus Univ., Poland. Ball, J. Wolfe and M.A. Valentovic. Wheeling Jesuit Univ. and A188 1105.20 The role of reactive oxygen species in the Marshall Univ. apoptotic effects of curcumin and simvastatin on lung cancer A201 1106.3 The role of choline depletion in cell line. S.H. Lee, I.K. Kim, H.I. Lee, H.Y. Lee, W.H. Ban, S.W. perfluorooctanesulfonate-induced hepatic steatosis. P. Kim, H.H. Kang and H.S. Moon. St. Paul’s Hosp., The Catholic Krishnan, A.D. Patterson, D.J. Ehresman, P.B. Smith, M.K. Univ., Seoul. Scavello, S-C. Chang, J.L. Butenhoff and J.M. Peters. Penn A189 1105.21 The effect of CBG (BDS) botanical cannabinoid State and 3M Co. extract on MCF-7 human breast carcinoma cells. F. Javid and A202 1106.4 Potentiation of cytotoxicity by two metabolites S. Fshinjavid. Sch. of Applied Sci., Univ. of Huddersfield, U.K. of 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione in HepG2 cells. A190 1105.22 Development of selective inhibitors of the S. Ejaz, R. Tchao and P.J. Harvison. Univ. of the Scis. in isoprenoid biosynthetic pathway and their effects on human- Philadelphia. derived chronic myelogenous leukemia cells. J.E. Reilly, X. A203 1106.5 Zinc oxide nanparticles induce apoptosis Zhou, H. Tong, D. Wiemer and R.J. Hohl. Univ. of Iowa. and necrosis in hepatocellular carcinoma HepG2 cells. S.M. A191 1105.23 Induction of autophagy by cisplatin-resistant Tadinada, M.B. Lai, V. Idikuda, K. Mukka, R.M. Singh, J. esophageal cancer cells promotes survival and recovery. L. Yu, Pfau, A. Bhushan, S. Leung and J.C.K. Lai. Idaho State Univ. C. Gu and S. Liu. Sch. of Pharmaceut. Sci., Southern Med. A204 1106.6 The possible antidotal effect of alpha-lipoic Univ., China. acid against acetaminophen-induced hepatotoxicity in rats. A192 1105.24 Pro-apoptotic agents induce ATP release from M.A. El-Moselhy, S.M. El-Shazly and W.A. Barakat. Fac. of leukemia/ lymphoma tumor cells via pannexin-1 dependent Pharm., Minia Univ. and Zagazig Univ., Egypt. and pannexin-1-independent mechanism. A.M. Boyd-Tressler A205 1106.7 Effects of fluoxetine and aspirin on bleeding and G.R. Dubyak. Case Western Reserve Univ. time and liver when used alone or in combination in rats. S. A193 1105.25 Modulation of indoleamine 2,3-dioxygenase Shrestha and N. Sookvanichsilp. Mahidol Univ., Thailand. pathway by a combination therapy strategy targeting myeloid A206 1106.8 Induction of neuronal nitric oxide synthase in derived suppressor cell function in lung cancer. C. Schafer, livers of mice treated with toxic doses of acetaminophen. R. T.H. Jin, A. Sawant, J. Roth, S. Grant, S. Ponnazhagan and Agarwal, S. Banerjee and J.A. Hinson. Univ. of Arkansas for J. Deshane. Univ. of Alabama at Birmingham. Med. Sci. A194 1105.26 Cyclin D2-mediated cardiomyocyte cell cycle A207 1106.9 Activation of autophagy by globular adiponectin activity reverses doxorubicin-induced cardiotoxicity. W. Zhu, attenuates ethanol-induced apoptosis in HepG2 cells. S. Nepal, M.H. Soonpaa, W. Zhang, W. Shou, R.M. Payne and L.J. M.J. Kim, A. Subedi and P-H. Park. Col. of Pharm., Yeungnam Field. Indiana Univ. Sch. of Med. Univ., South Korea. A195 1105.27 Prevention of cyclophosphamide-induced A208 1106.10 Alcohol exposure increases fibroblast growth alopecia by selegiline in a murine model. M.D. Berry, A.C. factor 21 expression. C. Zhao, Y. Liu, C. McClain and W. Feng. Gaiser, S.I. Chapman and P. Jackson. Brandon Univ., Univ. of Louisville and Louisville VA Med. Ctr. Canada. A209 1106.11 Fibroblast growth factor 21 is required for A196 1105.28 Differential effects of cisplatin on lung cancer alcohol-induced adipose tissue lipoatrophy in mice. Y. Liu, C. cells and primary neurons: roles of small GTPase RhoA. Z. Zhao, Y. Wang, C. McClain and W. Feng. Univ. of Louisville Weng, A. Friesland, Z. Lu, Y-H. Chen, F.M. Longo, C. Boykin and Louisville VA Med. Ctr. and Q. Lu. East Carolina Univ. and Stanford Univ. A197 1105.29 Role of RhoA in cisplatin–induced neurotoxicity. A.M. Friesland, M. Duenas, Z. Weng, F.M. Longo, Y-H. Chen and Q. Lu. East Carolina Univ. and Stanford Univ.
378 TUESDAY PHARMACOLOGY
1107. PULMONARY PHARMACOLOGY AND A218 1107.9 Sphingolipid biosynthesis and inflammatory TOXICOLOGY signaling in asthma. S. Ramachandran, A. Engel, G. Barton and J. Thorner. Univ. of California, Berkeley. Poster A219 1107.10 Follistatin-like 1 enhances cigarette smoke- induced interleukin-8 secretion from human airway smooth Tue. 7:30 am—Boston Convention & Exhibition Center, muscle cells. H. Cernecka, W.J. Poppinga, S.R. Jansen, M. Exhibit Halls A-B Schmidt, M.J.B. van den Hoff and H. Maarsingh. Univ. of Presentation time: 12:30 pm-2:30 pm Groningen, Netherlands and Acad. Med. Ctr., Amsterdam. A220 1107.11 Therapeutic efficacy of MJ33, a novel inhibitor A210 1107.1 Olaparib, a PARP inhibitor approved for of phospholipase A2 of peroxiredoxin 6, in LPS-induced acute human testing, prevents allergen-induced airway inflammation lung injury. I. Lee, C. Dodia, S. Chatterjee, S.I. Feinstein and and hyperresponsiveness in a mouse model of asthma and A.B. Fisher. Univ. of Pennsylvania. reduces proliferation of human CD3/C28-stimulated CD4+ T A221 1107.12 Differential expression of renin-angiotensin cells. M.A. Ghonim, A.S. Naura, P. Rodriguez, A. Al Khami, system components in the choroid plexus of betamethasone C. Hernandez, M.S. Mansy, A. Ochoa and H. Boulares. LSU exposed and control sheep. A.C. Marshall, H.A. Shaltout, N.T. Sch. of Med., New Orleans and Fac. of Pharm., Al-Azhar Univ., Pirro, J.C. Rose, D.I. Diz and M.C. Chappell. Wake Forest Egypt. Sch. of Med. and Sch. of Pharm., Alexandria Univ., Egypt. A211 1107.2 Validation of an early life candidate biomarker A222 1107.13 Pharmacological evaluation of Cissus for childhood asthma. H. Xu, T. Radabaugh, Z. Lu, D. quadrangularis fractionated extracts for bronchodilatory activity Billheimer, D. Vercelli, M. Halonen and S.S. Lau. Univ. of using guinea pigs. S.D. Patil and N.K. Kumavat. R.C. Patel Arizona. Inst. of Pharmaceut. Educ. and Res., Shirpur, India. A212 1107.3 Genetic influences in the development of A223 1107.14 Influence of hepatic P450-mediated amiodarone-induced pulmonary fibrosis. M. Hartog, B. Herron, amiodarone metabolism on amiodarone-induced pulmonary D. Lawrence and X. Ding. New York State Dept. of Hlth. and toxicity. M. Hartog, Y. Zhu, D. Lawrence, B. Herron and X. Sch. of Publ. Hlth., SUNY at Albany. Ding. New York State Dept. of Hlth. and Sch. of Publ. Hlth., A213 1107.4 Acetaminophen at low doses depletes airway Univ. at Albany SUNY. glutathione and alters respiratory reflex responses. G.J. Smith, A224 1107.15 Nerve growth factor reduces amiloride- J.A. Cichocki, J.E. Manautou and J.B. Morris. Univ. of sensitive Na+ transport in human airway epithelial cells. M.J. Connecticut. Shimko, E.J. Zaccone, J.A. Thompson, D. Schwegler-Berry, A214 1107.5 Role of biased signaling by beta-blockers in P.A. Willard and J.S. Fedan. West Virginia Univ. and NIOSH. the development of asthma phenotype in a murine model. A225 1107.16 Effects of popcorn butter flavorings, diacetyl V.J. Thanawala, G. Forkuo, N. Al-Sawalha, B. Knoll, P. Leff and 2,3-pentanedione, on isolated airway preparations. E.J. and R. Bond. Univ. of Houston and Pharmaceut. Consultant, Zaccone, J.A. Thompson, M.J. Shimko and J.S. Fedan. Cheshire, U.K. West Virginia Univ. and NIOSH. A215 1107.6 Role for A-kinase anchoring proteins in A226 1107.17 The role of the b2-adrenoceptor Gs pathway in cigarette smoke-induced barrier dysfunction. A. Oldenburger, the development of the asthma phenotype in murine models. W. Poppinga, F. Kos, W. Rijks, I. Heijink, W. Timens, H. Meurs, G.S. Forkuo, V.J. Thanawala, N. Sawalha, B. Knoll and R. H. Maarsingh and M. Schmidt. Univ. Med. Ctr. Groningen, Bond. Univ. of Houston. Netherlands. A227 1107.18 Informed target discovery for gene and stem A216 1107.7 Epac2 and PLCe contribute to the inflammatory cell therapy in acute lung injury. D.Y. Zhou, H. Amatullah, Y.X. response to cigarette smoke in vivo. A. Oldenburger, S. Bos, Shan, P. Gali, P.Z. Hu and C.C. dos Santos. Univ. of Toronto. A. Smrcka, H. Meurs, H. Maarsingh and M. Schmidt. Univ. of A228 1107.19 Losartan improves impaired vascular and Groningen, Netherlands and Univ. of Rochester Sch. of Med. endothelial responses in mice with allergic asthma. D.S. A217 1107.8 Effects of dabigatran on bleomycin-induced Ponnoth and S.J. Mustafa. West Virginia Univ. pulmonary toxicities and its safety profile in mice. N. Shrestha T and N. Sookvanichsilp. Mahidol Univ., Thailand. U E
POSTER PRESENTERS: Are you Tweeting about UPLOAD YOUR POSTER EB 2013? Where: E-Poster Counter, Sun. – Tue. Hall A; Wed. Hall C To Tweet use #EB2013 Deadline: Tue., April 23, 5:00 pm Be sure to follow EB on Facebook Wed., April 24, 3:00 pm Uploaded posters will be available online to all registered attendees following the meeting and Twitter . at www. experimentalbiology.org
379 PHYSIOLOGY TUESDAY Physiology
1108. HYPERTENSION III B11 1109.2 Metabolic reprogramming and miRNA expression profile in liver of prenatally dexamethasone-treated Poster rats. L.C. Pantaleão, L.R.B. Santos, L. Sakamoto, C. Lellis- Santos, P.R.L. Gomes, S.C. Rodrigues, M.Q. Latorraca and Tue. 7:30 am—Boston Convention & Exhibition Center, S. Bordin. Univ. of São Paulo and Fed. Univ. of Mato Grosso, Exhibit Halls A-B Brazil. Presentation time: 12:45 pm-3:00 pm B12 1109.3 Methyl-b-cyclodextrin increases GLUT4- mediated glucose transport in skeletal muscle fibers from B1 1108.1 Autophagy in RLVM mediates ER stress- insulin-resistant mice. P. Llanos, A. Contreras-Ferrat, C. associated neurogenic hypertension in SHR. Y-M. Chao, J.Y.H. Osorio-Fuentealba, A. Espinosa, J. Hidalgo, C. Hidalgo and Chan and S.H.H. Chan. Chang Gung Mem. Hosp.-Kaohsiung E. Jaimovich. Univ. of Chile, Chile and ICBM, Santiago. Med. Ctr. and Natl. Cheng Kung Univ., Taiwan. B13 1109.4 The upregulation of skeletal muscle B2 1108.2 Decreased transglutaminase activity in aorta inflammatory genes links inflammation with impaired insulin from hypertensive rats, measured by in situ detection of a free resistance in women with the metabolic syndrome. M.T.E. amine donor. H.G. Petersen-Jones, K.B. Johnson and S.W. Hopman, G. Lammers, F. Poelkens and C.J. Tack. Radboud Watts. Michigan State Univ. Univ. Nijmegen Med. Ctr., Netherlands. B3 1108.3 Effects of ethanol extract of Gastrodia elata B14 1109.5 Obesity and insulin resistance in adolescents: Blume on high-fructose induced metabolic syndrome. M.C. impact of renin angiotensin system. F.B. Fernandes, A.B. Kho, Y.J. Lee, Y.M. Ahn, Y.H. Choi, A.Y. Kim, D.G. Kang and Fernandes, A.C. da Silva Febba, M.S. de Souza Vitale, F.F. H.S. Lee. Wonkwang Univ., South Korea. Jung and D.E. Casarini. Fed. Univ. of São Paulo, Presbyterian B4 1108.4 Time course of changes in sympathetic nerve Mackenzie Univ. and Camilo Castelo Branco Univ., Brazil. activity during development of hypertension in spontaneously B15 1109.6 Induced pulp lesion promotes alteration of the hypertensive rats. N. Mineyama, M. Yoshimoto, M. Shirai and insulin signal and causes insulin resistance. D.H. Sumida, R.D. K. Miki. Nara Women’s Univ. and Natl. Cardiovasc. Ctr., Osaka. Astolphi, M.M. Curbete, F.Y. Chiba, A.P. Yamamoto, A.K.C. B5 1108.5 The balance between neural and hemodynamic Prieto and L.T.A. Cintra. São Paulo State Univ., Araçatuba. factors is abolished in hypertensive men. E. Hart, A. Burchell, B16 1109.7 Chronic treatment with NaF promotes L. Ratcliffe, A. Baumbach, A. Nightingale and J.F.R. Paton. dyslipidemia in rats. D.H. Sumida, C.A.S. Garbin, N.H. Sch. of Clin. Sci. and Bristol Heart Inst., Univ. of Bristol. Colombo, R.D. Astolphi and F.Y. Chiba. São Paulo State B6 1108.6 2,4,3´,5´-Tetramethoxystilbene reduces blood Univ., Araçatuba. pressure and associated cardiac fibrosis via inhibition of B17 1109.8 Effect of milk consumption and the glycemic cytochrome P450 1B1 and decreased oxidative stress in SHR. response on healthy college aged subjects. T.M. Fodstad, K.C. B.L. Jennings, D.E. Montanez, A.M. Estes, F.A. Yaghini and Ackermann and T. Wilson. Winona State Univ. K.U. Malik. Univ. of Tennessee, Memphis. B18 1109.9 BXD mouse lines as a genetic reference B7 1108.7 Carotid body denervation stunts development population for metabolic syndrome. S. Lamy. EPFL, Lausanne. of Goldblatt 2 kidney-1 clip hypertension in adult rats. F.D. B19 1109.10 Muscle-specific deletion of mTORC2 (Rictor) McBryde, A.P.L. Abdala, E.B. Hendy and J.F.R. Paton. Univ. blocks insulin stimulated Akt Ser 473 phosphorylation and of Bristol. impairs submaximal but not maximal insulin induced glucose B8 1108.8 Tissue-specific regulation of CB1/CB2 gene uptake. M. Kleinert, L. Sylow, T.E. Jensen, A-J. Oxboll and E. receptors in salt-sensitive hypertension of SHR. J. Varagic and Richter. Univ. of Copenhagen. P.E. Gallagher. Wake Forest Univ. B9 1108.9 Angiotensin II-induced hypertension results in 1110. RENAL HEMODYNAMICS AND GFR an oligioclonal T cell receptor expansion in mouse kidney. D.W. Trott, C-I. Li, Y. Shyr and D.G. Harrison. Vanderbilt Univ. Med. Poster Ctr. Tue. 7:30 am—Boston Convention & Exhibition Center, 1109. DIABETES AND INSULIN RESISTANCE III Exhibit Halls A-B
Presentation time: 12:45 pm-3:00 pm Poster B20 1110.1 Rho kinase inhibition counteracts tyrosine Tue. 7:30 am—Boston Convention & Exhibition Center, kinase inhibitor-induced rise in arterial pressure and renal Exhibit Halls A-B vascular resistance. O. Grisk, T. Meissner, A. Donner, D. Presentation time: 12:45 pm-3:00 pm Braun, U. Zimmermann and R. Rettig. Univ. of Greifswald, Germany. B10 1109.1 Effects of aerobic exercise training on obese B21 1110.2 Acute renal medullary interstitial infusion of female mice: metabolic and autonomic evaluation. M. Sartori, either saline or 2% albumin indistinctly rises RIHP and RMBF L.E. de Souza, P.R. de Souza, F. Santos, K. De Angelis and in the rat. M.E. Sánchez-Briones, J.F. López-Rodríguez, M.C. Irigoyen. Heart Inst. and Fac. of Med., Univ. of São Paulo M.Z. Calvo-Turrubiartes and M. Rodríguez-Martínez. and Nove de Julho Univ., Brazil. Autonomuos Univ. of San Luis Potosí, Mexico.
380 TUESDAY PHYSIOLOGY
B22 1110.3 The a2-adrenoceptor agonist, B35 1110.16 Renal autoregulation dynamics monitored dexmedetomidine, elicits pronounced decreases in arterial across the renal surface. C. Scully, N. Mitrou, B. Braam, W. blood pressure and renal hemodynamics in Cyp1a1-Ren2 Cupples and K. Chon. Worcester Polytech Inst., Simon Fraser transgenic rats with angiotensin II-dependent malignant Univ., Canada and Univ. of Alberta. hypertension. C.K. Thorngren, M.E. Patterson, P.D. Davis B36 1110.17 A pivotal role for pericytes in non-steroidal anti- and K.D. Mitchell. Tulane Univ. and Ochsner Hlth. Syst., New inflammatory drug-induced toxicity. C.M. Peppiatt-Wildman, Orleans. T. Kennedy-Lydon, C. Crawford and S.S.P. Wildman. B23 1110.4 Role of connexin 45 in the autoregulatory Medway Sch. of Pharm. and Royal Vet. Col., Univs. of Kent and response of the afferent arteriole. C.M. Sorensen, T.H. Greenwich, U.K. Braunstein and N-H. Holstein-Rathlou. Univ. of Copenhagen. B37 1110.18 Renal ischemia-reperfusion led to enhanced B24 1110.5 Nephrovascular interactions in a mathematical renal microvascular response to sphingosine-1-phosphate. model of rat renal autoregulation. I. Sgouralis and A. Layton. Z. Guan, S.T. Singletary, J. Van Beusecum, A.K. Cook and Duke Univ. E.W. Inscho. Georgia Hlth. Sci. Univ. B25 1110.6 Sequential assessment of glomerular filtration B38 1110.19 Potential sex differences in the vascular rate during development of hypertension in freely moving Dahl endothelial growth factor signaling pathway in the kidney. A. salt-sensitive rats. A.W. Cowley, Jr., R.P. Ryan, T. Kurth, D. Rouch and L. Fan. Oklahoma State Univ. Ctr. for Hlth. Sci. Schock-Kusch and N. Gretz. Med. Col. of Wisconsin and Univ. B39 1110.20 Acute podocyte injury enhances the of Heidelberg, Mannheim. susceptibility to blood pressure-induced injury in rats with B26 1110.7 N-acetyl-seryl-aspartyl-lysyl-proline (Ac- underlying ¾ renal mass reduction. A.J. Polichnowski, SDKP) prevents the progression of renal dysfunction in mice M.M. Picken, K.A. Griffin and A.K. Bidani. Hines VA Hosp. with lupus (MRL/lpr). T-D. Liao, P. Nakagawa, M. D’Ambrosio, and Loyola Univ. Chicago, Hines and Loyola Univ. Chicago, N-E. Rhaleb, X-P. Yang and O. Carretero. Henry Ford Hosp. Maywood. B27 1110.8 Resveratrol induces acute endothelium- B40 1110.21 Renal autoregulation is not impaired during dependent renal vasodilation. K.L. Gordish and W.H. early streptozotocin diabetes mellitus in Long-Evans rats. N. Beierwaltes. Wayne State Univ. and Henry Ford Hosp. Mitrou, F. Hansen, S. Morrison, P. Mousavi, C. Hong and W. B28 1110.9 Switch from ACE to chymase mRNA expression Cupples. Simon Fraser Univ., Canada. in diabetes in enriched renal vascular tissues harvested by B41 1110.22 Macula densa nitric oxide contributes to manual sieving. S.M. Ford, P.M. Berner and L.M. Harrison- anomalous tubuloglomerular feedback in subtotal nephrectomy Bernard. LSU Hlth. Sci. Ctr., New Orleans. rats on high salt diet. P. Singh, H. Pham, S. Khang and S. B29 1110.10 The role of nitric oxide in pericyte-mediated Thomson. UCSD and VA San Diego Healthcare Syst. and regulation of vasa recta diameter. C. Crawford, J.S. Pollock, O’Brien Core Ctr., San Diego. S.S.P. Wildman and C.M. Peppiatt-Wildman. Medway Sch. of B42 1110.23 ADP-ribosyl cyclase (CD38) and superoxide Pharm., Univs. of Kent and Greenwich, U.K. and Med. Col. of mediate renal vasoconstriction due to thromboxane receptor Georgia. (TpR) activation. N. Moss, T. Kopple and W. Arendshorst. B30 1110.11 Telemetry-based oxygen sensor to continuously Univ. of North Carolina at Chapel Hill. monitor renal cortical oxygenation in the conscious rat. M.P. B43 1110.24 Connecting tubule glomerular feedback in Koeners, C.P.C. Ow, R.G. Evans, D.M. Russell, J.A. Joles Dahl salt-sensitive and spontaneously hypertensive rats. and S. Malpas. Univ. of Auckland, New Zealand, Univ. Med. M.A. D’Ambrosio, H. Wang, J.L. Garvin, Y. Ren and O.A. Ctr. Utrecht, Netherlands, Monash Univ., Australia and Millar Carretero. Henry Ford Hosp. Instruments, Auckland. B44 1110.25 Electroacupuncture and moxibustion hinder B31 1110.12 Serine proteases affect in situ vasa recta the progression of renal disease by modulating systemic and capillary diameter: mechanism for kidney failure associated renal renin-angiotensin system. M.A. Naves, J.C. Paterno, with pancreatitis? R. Birch, C. Crawford, M. Kelly, R.J. Unwin, Z.P. Jara, F.B. Fernandes, D.E. Casarini, E.O. Sales and V.P. E. Schwiebert, S.S.P. Wildman and C.M. Peppiatt-Wildman. Teixeira. Fed. Univ. of São Paulo. T Medway Sch. of Pharm., Univs. of Kent and Greenwich, UCL U Med. Sch., Royal Free Hosp., London and DiscoveryBiomed 1111. RENAL WATER TRANSPORT, UREA Inc., Birmingham, AL. TRANSPORT AND COUNTERCURRENT E B32 1110.13 A novel role for GABA and glutamate in MECHANISMS pericyte-mediated regulation of medullary blood flow. K.N. Dunn, S.P. Kelley, C. Crawford, S.S.P. Wildman and C.M. Poster Peppiatt-Wildman. Medway Sch. of Pharm., Univs. of Kent and Greenwich, U.K. Tue. 7:30 am—Boston Convention & Exhibition Center, B33 1110.14 Inhibition of NADPH oxidase improves renal Exhibit Halls A-B autoregulation in rats fed a high salt diet. R.C. Fellner, M.I. Presentation time: 12:45 pm-3:00 pm Giddens and E.W. Inscho. Georgia Hlth. Sci. Univ. B34 1110.15 Attenuated contractility in afferent arterioles B45 1111.1 A novel small-molecule urea transporter during development of proteinuria in two-kidney, one-clip inhibitor acts as a potential diuretic. B. Yang, F. Li, T. Lei and H. hypertensive rats. T.D. Dahl, T. Skogstrand, F. Helle, M. Zhou. Peking Univ. Hultström, O. Tenstad and B.M. Iversen. Univ. of Bergen, B46 1111.2 Modeling the effects of medullary blood flow Norway, Univ. of Uppsala, Sweden and Haukeland Univ. Hosp., regulation on pressure natriuresis. R. Moss and A. Layton. Bergen. Duke Univ.
381 PHYSIOLOGY TUESDAY
B47 1111.3 Protein carbamylation is a physiological post- 1112. SEX DIFFERENCES IN RENAL FUNCTION AND translational modification in the renal inner medulla.J.S. DISEASE Claxton, G. Liu, P.C. Sandoval, C-L. Chou and M.A. Knepper. NHLBI, NIH. Poster B48 1111.4 Increased UT-A1 ubiquitination is partially due to decreased deubiquitination activity in streptozotocin-induced Tue. 7:30 am—Boston Convention & Exhibition Center, diabetic rat kidney inner medulla. H. Su, T.O. Ilori, J.D. Klein, Exhibit Halls A-B J.M. Sands and G. Chen. Emory Univ. Presentation time: 12:45 pm-3:00 pm B49 1111.5 Quantitative proteomics of hypokalemia induced nephrogenic diabetes insipidus. S. Khositseth, P. B62 1112.1 Sex does not impact asymmetric Somparn, P. Uawithya and S-H. Chen. Thammasat Univ., dimethylarginine or L-arginine levels in spontaneously Chulalongkorn Univ. and Mahidol Univ., Thailand and Natl. hypertensive rats. K.N. Brinson, S. Sharma, M.J. Romero Cheng Kung Univ., Taiwan. and J.C. Sullivan. Georgia Hlth. Sci. Univ. B50 1111.6 Membrane mobility of aquaporin-2 tagged with B63 1112.2 Estrogen supplementation increases renal photoconvertible fluorescence protein in mpkCCD cells. K-P. sodium absorption during high salt consumption in female and Yip, J. Amin, C-M. Tse and B. Cha. Univ. of South Florida and male mice. A. Rouch, L. Kudo, S. Nguyen and M. Nadeem. Johns Hopkins Univ. Oklahoma State Univ. Ctr. for Hlth. Sci. B51 1111.7 Progressive increase in collecting duct basal/ B64 1112.3 Postmenopausal response to angiotensin II- apical AQP2 expression ratio with increasing depth along the induced hypertension is blunted during perimenopause: a corticopapillary axis positively correlates with maximum urine study in the accelerated ovarian failure model of menopause. concentrating capacity. M. Espineira, R.L. Gilbert and T.L. D. Pollow, Jr., J. Perez, A. Booth, E. Constantopoulos, J.P. Pannabecker. Univ. of Arizona. Konhilas and H.L. Brooks. Univ. of Arizona. B52 1111.8 Genetic ablation of aquaporin-2 in the mouse connecting tubules results in defective renal water handling. 1113. SEX DIFFERENCES IN BLOOD PRESSURE AND M.L.A. Kortenoeven, N.B. Pedersen, R.L. Miller, A. Rojek FLUID VOLUME HOMEOSTASIS and R.A. Fenton. Aarhus Univ., Denmark and Univ. of Utah. B53 1111.9 Computer modeling of peristaltic contraction Poster and solute concentration in 3D inner medulla of the rat. P. Lee and D. Beard. Med. Col. of Wisconsin. Tue. 7:30 am—Boston Convention & Exhibition Center, B54 1111.10 Rapamycin, an inhibitor of mTOR signaling Exhibit Halls A-B pathway, reverses lithium-induced cell proliferation in renal Presentation time: 12:45 pm-3:00 pm collecting ducts. Y. Gao, J. Romero-Aleshire, Q. Cai, T.J. Price and H.L. Brooks. Univ. of Arizona. B65 1113.1 Angiotensin II-pretreated female but not male B55 1111.11 Dialysis efficacy at rest and during intra-dialytic rats are protected from pressor response and sympathetic exercise: agreement between serum and online Kt/V. C. Getz, activation to 2% saline drinking. T. Wei, S.C. Clayton, B. Xue, T. Parsons, R. Morton, E. Toffelmire and C. King-VanVlack. M. Hay and A.K. Johnson. Univ. of Iowa and Univ. of Arizona. Queen’s Univ., Canada. B66 1113.2 Sex-specific actions of the prostaglandin E B56 1111.12 Outer medullary Na-K-ATPase activity and type 4 receptor to attenuate salt sensitivity and hypertension. protein expression levels of the highly concentrating kangaroo M. Herrera, B. Koller and T.M. Coffman. Duke Univ. and Univ. rat exceed those of Sprague-Dawley or Munich-Wistar rats. of North Carolina at Chapel Hill. T.M. Armstrong, M. Shahidullah and T.L. Pannabecker. Univ. B67 1113.3 Neither hypertension nor sexual maturation of Arizona. is responsible for elevated mesenteric arterial expression of B57 1111.13 Prox1 expression in the ascending thin limb of TGF-b in female spontaneously hypertensive rats. A.J. Tipton, Henle’s loop is regulated by osmolality. J. Kim, Y-M. Kim, W-Y. M. Womack and J. Sullivan. Georgia Hlth. Sci. Univ. Kim and S-A. Nam. The Catholic Univ. of Korea. B68 1113.4 Effects of estrogen on relaxation rates in rat B58 1111.14 Urea permeabilities in defined segments of rat caudal artery. I. Allawzi, A. Garcia, O. Uzomah and N. Pelaez. renal inner medullary thin limbs of Henle’s loops. K.K. Evans, Purdue Univ. T.L. Pannabecker and W.H. Dantzler. Univ. of Arizona. B59 1111.15 Gene expression in the thin limbs of Henle of 1114. OBESITY AND INFLAMMATION: the water-restricted rat. C.M. Nawata, W.H. Dantzler and T.L. CONTRIBUTIONS TO VASCULAR AND RENAL Pannabecker. Univ. of Arizona. DISEASE (POSTERS) B60 1111.16 RNA-Seq analysis of glycosylation related gene expression in streptozotocin-induced diabetic rat kidney Poster inner medulla. G. Chen, X. Li, H. Su, T.O. Ilori, J.D. Klein and R.P. Hughey. Emory Univ. and Univ. of Pittsburgh Sch. of Med. Tue. 7:30 am—Boston Convention & Exhibition Center, B61 1111.17 Transgenic mice expressing UT-A1, but lacking Exhibit Halls A-B UT-A3, have intact urine concentrating ability. J.D. Klein, O. Presentation time: 12:45 pm-3:00 pm Fröhlich, A.C. Mistry, K.J. Kent, C.F. Martin and J.M. Sands. Emory Univ. B69 1114.1 Weight-loss surgery rapidly alleviates platelet hyperactivity in morbid obesity. Y. Dobrydneva, M. Periasamy, M. Butcher, E. Galkina, N. Kuhn, D. Lieb, M. Fontana, S. Wohlgemuth and J. Nadler. Eastern Virginia Med. Sch. and Sentara Med. Gp., Norfolk.
382 TUESDAY PHYSIOLOGY
B70 1114.2 Role of the angiotensin AT2 receptor in obesity- B83 1115.6 Genetic defects in congenital solitary kidney linked inflammation and renal injury: effect of gender. I. Dhande, rats cause low nephron numbers and predispose to severe M.A. Khan, S. Nag and T. Hussain. Univ. of Houston. renal damage. X. Wang, A.C. Johnson, J. Lee, L. Solberg- B71 1114.3 Etanercept improves glucose intolerance and Woods and M.R. Garrett. Univ. of Mississippi Med. Ctr. and dyslipidemia in insulin-resistant rats. A. Lee, R. Rodriguez, Med. Col. of Wisconsin. R. Ortiz and M. Ryan. Univ. of California Merced and Univ. of B84 1115.7 Hypertension in a rat model of HELLP Mississippi Med. Ctr. syndrome is associated with increased TNF-alpha, IL-6 and B72 1114.4 Mutation of Sh2b3 attenuates Dahl SS CD4+ T cell activation. K. Wallace, M. Darby, P. Kyle, R. Morris, hypertension via inflammatory signaling.N. Rudemiller, H. J. Moseley, K. Frazier and B. LaMarca. Univ. of Mississippi Lund, C. Guo, A. Geurts, H. Jacob and D.L. Mattson. Med. Med. Ctr. Col. of Wisconsin. B85 1115.8 Sodium storage during high salt intake is not B73 1114.5 Effect of high-fat diet on resistance artery dependent upon endothelin B receptors. J.S. Speed, J.M. Titze function in normal pregnant rats. F.T. Spradley, A.C. Palei and and D.M. Pollock. Georgia Hlth. Sci. Univ. and Vanderbilt Univ. J.P. Granger. Univ. of Mississippi Med. Ctr. B86 1115.9 Hypertonic NaCl intake induces renal TNF B74 1114.6 Acute kidney injury following orthopedic trauma production by a pathway involving NKCC2A and NFAT5. S. in obese Zucker rats. P. Mittwede, L. Xiang, J. Clemmer, S. Lu, Hao, L. Bellner and N.R. Ferreri. New York Med. Col. A. Gowdey and R. Hester. Sch. of Med., Univ. of Mississippi B87 1115.10 Mechanisms of shear stress mediated nitric Med. Ctr. oxide production by inner medullary collecting duct cells. K.A. B75 1114.7 The impact of high mobility group box 1 protein Hyndman and J.S. Pollock. Georgia Hlth. Sci. Univ. on renal ischemia-reperfusion injury in male and female B88 1115.11 Protein carbonylation regulates renal proximal spontaneously hypertensive rats. G.R. Crislip, A.J. Tipton and tubular Na/K-ATPase signaling and sodium transport. Y. Yan, J.C. Sullivan. Georgia Hlth. Sci. Univ. Z-j. Xie, J.I. Shapiro and J. Liu. Joan C. Edwards Sch. of Med., B76 1114.8 Impaired pancreatic function contributes to the Marshall Univ., Yanshan Univ., China and Univ. of Toledo. age-dependent development of metabolic syndrome in female B89 1115.12 Dynamin 2 is a Ca2+-dependent regulator of intrauterine growth-restricted rats. S. Intapad, A.D. Brown, NOS1a and a possible negative regulator of NOS1b. S.K.H. F.L. Tull, J.M. Fahling, J.H. Dasinger, N.B. Ojeda and B.T. Morsing, K.A. Hyndman and J.S. Pollock. Georgia Hlth. Sci. Alexander. Univ. of Mississippi Med. Ctr. Univ. and Karolinska Inst. B77 1114.9 Vascular smooth muscle specific deletion of the B90 1115.13 Altered thick ascending limb function in aging leptin receptor attenuates leptin-induced vascular dysfunction. female mice consuming high quantities of fructose-sweetened T.T. Coleman, D.E. Stec and M.J. Ryan. Univ. of Mississippi water. L. Li, A. Yunghans, S-B. Awan, L. Alamri and C. Med. Ctr. Ecelbarger. Georgetown Univ. B91 1115.14 Genotype-phenotype relationship in patients 1115. WATER AND ELECTROLYTE HOMEOSTASIS: affected by novel CLCNKB mutations. O. Andrini, M. Keck, A. PATHOPHYSIOLOGY AND PHYSIOLOGY Blanchard, R. Vargas-Poussou, S. Lourdel and J. Teulon. UPMC Univ. and Européen Hosp. Georges Pompidou, Paris. Poster B92 1115.15 Atractylodes macrocephala regulates water channel protein expression by hypertonic stress in renal Tue. 7:30 am—Boston Convention & Exhibition Center, collecting duct cells. Y.P. Lee, Y.J. Lee, S.M. Lee, J.J. Yoon, Exhibit Halls A-B D.H. Kim, B. Li, D.G. Kang and H-S. Lee. Wonkwang Univ., South Korea. Presentation time: 12:45 pm-3:00 pm B93 1115.16 Effect of Poria cocos on hypertonic stress- B78 1115.1 Renal intramedullary infusion of tempol induced water channel expression and apoptosis in renal normalizes the blood pressure response to intrarenal blockade collecting duct cells. S.M. Lee , Y.J. Lee, J.J. Yoon, B. Li, Y.P. of heme oxygenase-1 in angiotensin II-dependent hypertension. Lee, D.H. Kim, D.G. Kang and H.S. Lee. Wonkwang Univ., T D. Stec and M. Gousset. Univ. of Mississippi Med. Ctr. South Korea. B79 1115.2 Indoleamine-2,3-dioxygenase restrains B94 1115.17 Peroxisome proliferator activated receptor – U hypertension induced by angiotensin II in rats fed a high salt alpha regulation of sodium transport mechanisms in human E diet. K. H. Yiew, S.K. Yoon, L. Huang, C. Jin, A.L. Mellor and primary renal proximal tubule epithelial cells during acute D.M. Pollock. Georgia Hlth. Sci. Univ. angiotensin II treatment. K. Doh, T. Hudson and D.L. Lee. B80 1115.3 Increases in renal medullary 20-HETE Univ. of Maryland Baltimore County and Howard Univ. formation oppose the development of hypertension and B95 1115.18 The effects of intermittent heat acclimation improves pressure natriuresis in CYP4A1 transgenic Dahl on water balance in rats. J. Johnson, A. Beck, E. Ray, V. S rats. S. Murphy, F. Fan, R. Baker and R. Roman. Univ. of Janardan and C. Barney. Hope Col., MI. Mississippi Med. Ctr. B96 1115.19 Biomarkers of kidney disease identified using B81 1115.4 Blunting circulating TH17 cells decreases a novel rat model and evaluated in human CKD patients. A.C. hypertension and oxidative stress in response to placental Harmon, A.C. Johnson, A. Driesbach and M.R. Garrett. ischemia. D.C. Cornelius, J.P. Hogg, K. Wallace, J. Moseley Univ. of Mississippi Med. Ctr. and B. LaMarca. Univ. of Mississippi Med. Ctr. B97 1115.20 Glycogen synthase kinase-3 inhibition reduces B82 1115.5 Regulation of renal sodium excretion by renal cystogenesis in polycystic kidney disease. R. Rao, S. Tao, medullary NLRP3 inflammasome activation beyond turning on E. Suderman and P. Pandey. Univ. of Kansas Med. Ctr. inflammation. M. Xia, J. Xiong, J.M. Abais, K.M. Boini and B98 1115.21 A novel treatment for X-linked nephrogenic P-L. Li. Virginia Commonwealth Univ. diabetes insipidus: the secret in secretin? G. Procino, S. Milano, M. Carmosino, M.C. Nicoletti, J. Wess and M. Svelto. Univ. of Bari, Italy and NIDDK, NIH.
383 PHYSIOLOGY TUESDAY
B99 1115.22 What is the physiological relevance of the 1117. ASSESSING POSTGANGLIONIC SYMPATHETIC renal H,K-ATPase type 2? Example of K+ reabsorption during NEURONAL DISCHARGE PATTERNS: K+ depletion, gestation and circadian rhythm. G. Crambert, C. IMPLICATIONS FOR UNDERSTANDING Lamouroux and A. Salhi. INSERM, Univ Paris 6 - Univ Paris ABERRANT SYMPATHETIC OUTFLOW 5, CNRS. (POSTERS) B100 1115.23 Usp2-45 represses aldosterone response by decreasing mineralocorticoid receptor availability. O. Staub, A. Poster Debonneville, D. Pouly and N. Faresse. Univ. of Lausanne. B101 1115.24 Vacuolar proton pump a4 subunit is critical Tue. 7:30 am—Boston Convention & Exhibition Center, for inner ear development and renal function. N. Picard, J-C. Exhibit Halls A-B Hennings, A. Huebner, T. Stauber, H. Maier, D. Brown, T. Presentation time: 12:45 pm-3:00 pm Jentsch, R. Vargas-Poussou, D. Eladari and C. Huebner. INSERM, Paris, Inst. for Human Genet., Jena, Max Delbrück B109 1117.1 A case for a standardized method for the Ctr. for Molec. Med., Berlin and Hannover Med. Sch., Germany, normalization of muscle sympathetic nerve activity amplitude. Massachusetts Gen. Hosp. and Hosp. Georges Pompidou, D.W. White, V.L. Kay, G. Moralez, W.L. Eubank and P.B. Paris. Raven. Univ. of North Texas Hlth. Sci. Ctr. at Fort Worth. B102 1115.25 Rh proteins mediated ammonia excretion in the B110 1117.2 Augmented response of renal sympathetic skin of zebrafish larvae: evidence of active ammonia transport nerve single units to chemoreceptor stimuli in rabbits with by ionocytes. T-H. Shih, J-L. Horng, Y-T. Lai and L-Y. Lin. Natl. angiotensin-induced hypertension. G.A. Head, S.L. Burke Taiwan Normal Univ. and Taipei Med. Univ. and E.V. Lukoshkova. Baker IDI Heart and Diabetes Inst., B103 1115.26 Enhanced urinary sodium and potassium Melbourne and Natl. Cardiol. Res. Ctr., Moscow. excretion in VAMP3 knockout mice. M.Z. Haque and P.A. Ortiz. B111 1117.3 Sympathetic vascular transduction following Henry Ford Hosp. spontaneous MSNA bursts is augmented in young black men. D.P. Credeur, S.W. Holwerda, S.T. Fairfax, D.M. Keller and 1116. NEUROHUMORAL MECHANISMS OF BLOOD P.J. Fadel. Univ. of Missouri-Columbia and Univ. of Texas at PRESSURE AND VOLUME REGULATION Arlington. B112 1117.4 Sympathetic and cardiovagal baroreflex Poster sensitivity in humans: comparison of Valsalva’s maneuver and spontaneous methodologies. H. Yang and J.R. Carter. Tue. 7:30 am—Boston Convention & Exhibition Center, Michigan Technol. Univ. Exhibit Halls A-B B113 1117.5 Sympathetic nerve activity and systemic
Presentation time: 12:45 pm-3:00 pm arterial pressure during obstructive sleep apnea in conscious rats. C. Sukeguchi and K. Miki. Nara Women’s Univ., Japan. B104 1116.1 Is there truly a sympathetic component B114 1117.6 Effect of mental stress on skin sympathetic to aldosterone hypertension? T. Lohmeier, B. Liu and D. nerve activity: are responses reproducible? C.A. Ray, C.L. Georgakopoulos. Univ. of Mississippi Med. Ctr. and CVRx Sauder and M.D. Muller. Penn State, Hershey. Inc., Minneapolis. B115 1117.7 Evaluation of muscle sympathetic nerve B105 1116.2 Nicotine reduces blood pressure in mouse activity in patients with chronic severe aortic insufficiency. model of systemic lupus erythematosus. K.W. Mathis. Univ. of S.B.P.C. Souza, T.A.D. Accorsi, M. Katz, O.C. Bezerra, G.A. Mississippi Med. Ctr. Neves, M.B.P. Grinberg, F.M. Consolim-Colombo and F.B.P. B106 1116.3 Nitric oxide impacts on angiotensin AT2 Tarasoutchi. Clin Hosp., Sch. of Med., Univ. of São Paulo. receptors modulation of high-pressure baroreflex control of renal sympathetic nerve activity in rats. M.H. Abdulla and E.J. 1118. NEURAL CONTROL OF CARDIOVASCULAR Johns. University Col. Cork, Ireland. FUNCTION B107 1116.4 Vasopressin infusion increases intravesical pressure in Wistar rats. E.M. Cafarchio, L.A. Silva, E. Poster Colombari, C.A. Ogihara, R.L. Almeida and M.A. Sato. Fac. of Med., ABC, Santo Andre, Brazil and São Paulo State Univ., Tue. 7:30 am—Boston Convention & Exhibition Center, Araraquara. Exhibit Halls A-B B108 1116.5 Renal effects produced by microinjection of Presentation time: 12:45 pm-3:00 pm kappa opioid agonist into the bed nuclei of the stria terminalis (BST). C. Franklin, Y. Rangel, L. Fortepiani, G. Toney and H. B116 1118.1 The effect of gender on sympathetic neural Gottlieb. Sch. of Optom., Univ. of Incarnate Word and Univ. of responses to cold pressor testing in hypertensive seniors. J.M. Texas Hlth. Sci. Ctr. at San Antonio. Hendrix, T. Bivens, S. Best, Y. Okada, B.D. Levine and Q. Fu. Univ. of Texas Southwestern Med. Ctr. and Inst. for Exercise and Envrn. Med., Dallas. B117 1118.2 Macrophage migration inhibitory factor LAST DAY TO decreases neuroinflammation in the solitary tract nucleus of spontaneously hypertensive rats. A.H. Freiria-Oliveira, VISIT EXHIBITS G.T. Blanch, H. Li, D.S.A. Colombari, E. Colombari and C. Sumners. FOAR-UNESP, Brazil, Univ. of Florida and Southern Tuesday, April 23 Med. Univ., China. 9:00 AM – 4:00 PM
384 TUESDAY PHYSIOLOGY
B118 1118.3 Elderly blacks have a similar sympathetic B132 1118.17 Lack of interaction of co-existing TRPV1 and neural responsiveness but greater pressor response to cold CB1 receptors indicates differential control of separate basal stress than elderly whites. Y. Okada, J. Edwards, S.S. Jarvis, and synchronous glutamate release mechanisms in the S.A. Best, R.L. Meier, T.B. Bivens, W. Vongpatanasin, B.D. solitary tract nucleus. M.C. Andresen, M.E. Hofmann and J.A. Levine and Q. Fu. Texas Hlth. Presbyterian Hosp. Dallas and Fawley. Oregon Hlth. & Sci. Univ. Univ. of Texas Southwestern Med. Ctr. B133 1118.18 Individual differences in cardiac and vascular B119 1118.4 P2Y1-receptors are expressed by C1 cells and components of the pressor responses to isometric handgrip regulate peripheral chemoreceptor modulation of breathing and exercise in humans. K. Watanabe, M. Ichinose, R. Tahara and blood pressure. I.C. Wenker, C.R. Sobrinho, A.C. Takakura, T. Nishiyasu. Univ. of Tsukuba and Meiji Univ., Japan. T.S. Moreira and D.K. Mulkey. Univ. of Connecticut and Univ. B134 1118.19 Hormone-phase dependence of muscle of São Paulo. sympathetic nerve activity in young healthy women using B120 1118.5 Activation of NMDA receptors results in hormonal contraceptives. C.W. Usselman, T.A. Luchyshyn, T.I. different autonomic and cardiovascular responses along Gimon, C.A. Nielson, S.H.M. Van Uum and J.K. Shoemaker. the rostrocaudal axis of the insular cortex. F.R. Marins, M. Sch. of Kinesiol. and Schulich Sch. of Med. and Dent., Western Limborço-Filho, G.C. Vaz, C.H. Xavier and M.A.P. Fontes. Univ., Canada. Fed. Univ. of Minas Gerais, Brazil. B135 1118.20 Rheumatoid arthritis and arterial baroreflex B121 1118.6 Distension of central great vein decreases function. A.M. Adlan, G. Kitas, J.F.R. Paton, G.Y.H. Lip and sympathetic outflow in humans. J. Cui, Z. Gao, C. Blaha, J. J.P. Fisher. Univ. of Birmingham, Russells Hall Hosp., Dudley, Mast, M.D. Herr and L.I. Sinoway. Penn State Col. of Med. Univ. of Bristol and City Hosp., Birmingham, U.K. B122 1118.7 Cardiovascular responses during static skeletal B136 1118.21 Diminished baroreflex function following muscle contraction following neuronal NOS blockade within the ovariectomy is a consequence of the reduced excitability ventrolateral medulla. A. Ally and T.J. Maher. South Col. Sch. of a sex-specific population of low threshold myelinated of Pharm., KY and Massachusetts Col. of Pharm. & Hlth. Sci. baroreceptor afferents in the rat. G.C. Santa Cruz Chavez, B. B123 1118.8 Respiratory influences on muscle sympathetic Li and J.H. Schild. Indiana Univ.-Purdue Univ. Indianapolis. nerve activity and limb vascular conductance in the steady- B137 1118.22 Auditory and visual stimuli evoke a state. J.K. Limberg, B.J. Morgan, W.G. Schrage and J.A. synchronized activation of sympathetic, respiratory and motor Dempsey. Sch. of Educ. and Sch. of Med. and Publ. Hlth., Univ. outputs after disinhibition of midbrain colliculi. F.C.F. Muller- of Wisconsin-Madison. Ribeiro, M.P. Fontes, R.A.L. Dampney and A.K. Goodchild. B124 1118.9 The exaggerated exercise pressor reflex in Macquarie Univ., Australia, Fed. Univ. of Minas Gerais, Brazil heart failure: MAPK activation in peripheral dorsal root ganglia. and Sydney Univ. H. Wang, W. Wang, G.J. Rozanski and I.H. Zucker. Univ. of B138 1118.23 Influence of age on respiratory modulation Nebraska Med. Ctr. of muscle sympathetic nerve activity and blood pressure B125 1118.10 Afferent vagal nerve stimulation resets the in humans. A. Shantsila, D.B. McIntyre, G.Y.H. Lip, J.F.R. baroreflex neural arc and inhibits sympathetic nerve activity. Paton, P.J. Fadel, A.E. Pickering and J.P. Fisher. Univ. K. Saku, K. Sakamoto, K. Hosokawa, T. Kakino, M. Ikeda, of Birmingham and City Hosp., U.K., Univ. of Bristol Sch. of Y. Oga, A. Nishizaki, T. Ide and K. Sunagawa. Kyushu Univ., Physiol. & Pharmacol. and Univ. of Missouri-Columbia. Japan. B139 1118.24 Gene expression of NMDA receptor subunits B126 1118.11 Hyperadrenergic activity and the postural using laser capture microdissection in the rostral ventrolateral tachycardia syndrome. D.A. Low, M.A. Akhtar, V. Iodice, L. medulla of sedentary versus physically active rats. M. Watson and C.J. Mathias. Imperial Col. London and Natl. Subramanian, A.G. Holt and P.J. Mueller. Wayne State Univ. Hosp. for Neurol. and Neurosurg., London. B140 1118.25 Immunofluorescence identifies the a1 subunit
B127 1118.12 Elevated brain-derived neurotrophic factor of the GABA A receptor on spinally projecting neurons in rostral levels in the paraventricular nucleus increase blood pressure, ventrolateral medulla. M.D. Dombrowski, I.J. Llewellyn-Smith heart rate and indices of sympathetic activity. B. Erdos, I. and P.J. Mueller. Wayne State Univ. Sch. of Med. and Flinders T Backes, M.L. McCowen and D.A. Scheuer. Univ. of Florida. Med. Ctr., Australia. B128 1118.13 Severe hemorrhage attenuates B141 1118.26 Water drinking enhances the gain of arterial U cardiopulmonary chemoreflex control of renal and adrenal baroreflex control of muscle sympathetic nerve activity in E sympathetic nerves via adenosine operating in the nucleus of healthy humans. L.C. Vianna, I.A. Fernandes, D.G. Martinez, the solitary tract. Z. Minic, C. Li, D.S. O’Leary and T.J. Scislo. B.M. Silva, P.J. Fadel and A.C. Nobrega. Fluminense Fed. Wayne State Univ. Sch. of Med. Univ. and Salgado Oliveira Univ., Brazil and Univ. of Missouri- B129 1118.14 Sympathoinhibition in men during paced Columbia. breathing at 0.25 Hz. N. Coverdale, C.W. Usselman, T.I. B142 1118.27 Heart rate variability and cardiorespiratory Gimon, C.A. Nielsen, T.A. Luchyshyn and J.K. Shoemaker. fitness in African American men.R.L. Herron and M.R. Esco. Western Univ., Canada. Univ. of Alabama and Auburn Univ. Montgomery. B130 1118.15 Immunohistochemistry confirms the functional B143 1118.28 Neurocardiovascular effects of V1b receptor evidence that the cardiopulmonary chemoreflex pathways in blockade within paraventricular nucleus in conscious Sprague the caudal nucleus of the solitary tract are directly inhibited by Dawley rats. W.M. El Werfali, M. Maliszewska-Scislo, H.
A1 adenosine receptors and indirectly inhibited by A2a receptor Chen and N.F. Rossi. Wayne State Univ. and John D. Dingell Z. Minic, D.S. O’Leary, H.G. Goshgarian and T.J. Scislo. VA Med. Ctr. Wayne State Univ. Sch. of Med. B144 1118.29 Sympatho-inhibition in an ovine model of septic B131 1118.16 Muscle metaboreflex-induced increases in shock: cardiovascular and renal effects. C. May, R. Bellomo ventricular performance are limited in hypertension due to and P. Calzavacca. Florey Inst. of Neurosci. and Ment. Hlth. exaggerated coronary vasoconstriction. M.D. Spranger, J.A. and Austin Hlth., Melbourne. Sala-Mercado, J. Kaur, R. Abu-Hamdah and D.S. O’Leary. Wayne State Univ. Sch. of Med. 385 PHYSIOLOGY TUESDAY
B145 1118.30 Increasing leptin sensitivity via PTP1B deletion 1119. NEURAL CONTROL OF CARDIOVASCULAR does not increase blood pressure through an increased FUNCTION: THE VASCULATURE sympathetic tone in mice on a Balb/c background. B.R. Butler, J.B. Norman, M.L. Tremblay and E.J. Belin de Chantemele. Poster Georgia Hlth. Sci. Univ. and McGill Univ. B146 1118.31 Continuous and intermittent electrical Tue. 7:30 am—Boston Convention & Exhibition Center, stimulation of the aortic depressor nerve in conscious rats: Exhibit Halls A-B time course of the hemodynamic responses. H. Salgado, F. Presentation time: 12:45 pm-3:00 pm Brognara, D.P.M. Dias, J.A. Castania and R. Fazan, Jr. Univ. of São Paulo, Ribeirão Preto. B157 1119.1 Impaired hypoxic vasodilation in healthy older B147 1118.32 Technique-dependent considerations when adults: role for altered sympatho-adrenal control of vascular assessing racial differences in arterial baroreflex function.D.M. tone. J.C. Richards, A.R. Crecelius, B.S. Kirby, L.J. Garcia, Keller, S.W. Holwerda, D.P. Credeur and P.J. Fadel. Univ. of G.J. Luckasen, D.G. Larson and F.A. Dinenno. Colorado Texas at Arlington and Univ. of Missouri-Columbia. State Univ. and Med. Ctr. of Rockies, Loveland, CO. B148 1118.33 Carotid baroreflex control of heart rate is B158 1119.2 The role of a-adrenergic receptors in mediating enhanced during whole-body heat stress. D. Krnjajic, C.L. beat-by-beat sympathetic vascular transduction in resting Butts, W.S. Warren, M.R. Samels and D.M. Keller. Univ. of humans. S.T. Fairfax, D.P. Credeur, S.W. Holwerda, M.Y. Texas at Arlington. Zuidema, J.H. Medley, P.C. Dyke II and D.W. Wray. Univ. of B149 1118.34 Arterial baroreflex control of sympathetic Missouri-Columbia and Univ. of Utah. nerve activity during acute hypotension is enhanced in young B159 1119.3 Alternative pathway to angiotensin converting normotensive black men. S.W. Holwerda, D.M. Keller, D.P. enzyme for angiotensin II generation in mouse mesenteric Credeur and P.J. Fadel. Univ. of Missouri-Columbia and Univ. artery. C. Becari, M.A. Barbosa da Silva, H.C. Salgado, of Texas at Arlington. R.C.A. Tostes, E.B. Oliveira and M.C.O. Salgado. Fac. of B150 1118.35 Astrocytes influence SON and PVN Med. of Ribeirão Preto, Univ. of São Paulo. neurosecretory and presympathetic neuronal excitability B160 1119.4 Effects of the reversible acetylcholinesterase via activation of an extrasynaptic NMDA/A-type K+ channel inhibitor pyridostigmine on vascular reactivity of spontaneously coupling mechanism. K. Naskar and J.E. Stern. Georgia Hlth. hypertensive rats. R.M. Lataro, M.A.B. Silva, R.C.A. Tostes Sci. Univ. and H.C. Salgado. Sch. of Med. of Ribeirão Preto, Univ. of São B151 1118.36 A novel relationship between estrogen, insulin Paulo. resistance, and cardiovagal baroreflex sensitivity in obese B161 1119.5 The 5-HT1A receptor and sympathetic PCOS women. J.A. Miner, J.C. Miner, V.E. Brunt, P.F. Kaplan neurotransmission to mesenteric blood vessels in salt-sensitive and C.T. Minson. Univ. of Oregon and Oregon Hlth. & Sci. Univ. hypertension. J.D. Bomar and J.J. Galligan. Michigan State B152 1118.37 An inverse relationship between testosterone Univ. and muscle sympathetic nerve activity: an investigation in lean healthy females. E.E. Madison, J.C. Miner, J.A. Miner, P.F. 1120. NEURAL CONTROL OF VISCERAL AND Kaplan and C.T. Minson. Univ. of Oregon and Oregon Hlth. & METABOLIC FUNCTION Sci. Univ. B153 1118.38 The neurosteroid metabolite of progesterone, Poster 3a-OH-dihydroprogesterone, is required for attenuated baroreflex mediated sympathoexcitation in pregnancy. J.G. Tue. 7:30 am—Boston Convention & Exhibition Center, Phaup, E.M. Hasser and C.M. Heesch. Univ. of Missouri- Exhibit Halls A-B Columbia. Presentation time: 12:45 pm-3:00 pm B154 1118.39 Testosterone increases muscle sympathetic nerve activity in young healthy males. J.C. Miner, J.A. Miner, B162 1120.1 Further studies on the sensory motor P.F. Kaplan and C.T. Minson. Univ. of Oregon and Oregon integration of gill lateral cilia in the bivalve mollusc Crassostrea Hlth. & Sci. Univ. virginica. P. Williams, P. Akande, E.J. Catapane and M.A. B155 1118.40 Autonomic reflexes may contribute to the Carroll. Medgar Evers Col., CUNY. symptomatology of mal de debarquement syndrome. T.E. B163 1120.2 Glycemic control by the brain renin-angiotensin Wilson, A.D. LePorte, K. Toma, J.S. Thomas and B.C. Clark. system: role for peripheral AT2 receptors. B.J. Weidemann, Ohio Univ. Heritage Col. of Osteo. Med. N.K. Littlejohn, C.D. Sigmund and J.L. Grobe. Univ. of Iowa. B156 1118.41 Mindfulness meditation lowers blood pressure B164 1120.3 Shp2 signaling in Pomc neurons is important and sympathetic activity in hypertensive patients with chronic for leptin’s actions on blood pressure, energy balance and kidney disease. J. Park and S. Bauer-Wu. Emory Univ. Sch. of glucose homeostasis. J.M. do Carmo, A.A. da Silva, P.O. Med. and Sch. of Nursing. Sessums, S.H. Ebaad and J.E. Hall. Univ. of Mississippi Med. Ctr. B165 1120.4 Glucoprivation of hypothalamic neurons elicits the counter-regulatory response in rats. T.J. Verberne and W.S. Korim. Univ. of Melbourne. B166 1120.5 Systemic CCK increases brown adipose tissue sympathetic nerve activity. C.J. Madden. Oregon Hlth. & Sci. Univ.
386 TUESDAY PHYSIOLOGY
1121. BLOOD BRAIN BARRIER, BLOOD FLOW AND 1123. CENTRAL REGULATION OF FOOD INTAKE AND METABOLISM BODY WEIGHT
Poster Poster
Tue. 7:30 am—Boston Convention & Exhibition Center, Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Exhibit Halls A-B
Presentation time: 12:45 pm-3:00 pm Presentation time: 12:45 pm-3:00 pm B167 1121.1 In vitro modeling of inflammation-induced B177 1123.1 Control of feeding behavior by CRH 2 blood-brain barrier dysfunction in sickle cell disease. H. receptors in the paraventricular nucleus of the hypothalamus of Parfenova, T. Pestina, D. Persons and S. Basuroy. Univ. of adrenalectomized rats. M. Rito-Domingo, V.E. López Alonso, Tennessee, Memphis and St. Jude Children’s Res. Hosp. K.A. Reyes Santos, G. Ambrocio Segundo, K. Cruz García B168 1121.2 Role of NOS in early-stage BBB disruption and J.M. Mancilla Díaz. Natl. Autonomous Univ. of Mexico. following transient focal cerebral ischemia. Z. Jiang, C. Li, D.M. B178 1123.2 Nesfatin-1 does not influence intracellular Arrick, S. Yang and H. Sun. LSU Hlth. Sci. Ctr.-Shreveport. calcium concentrations in neurons of the nucleus of the B169 1121.3 Cerebrovascular reactivity and implications solitary tract or the paraventricular nucleus. A. Mimee and A.V. for understanding the pathophysiology of multiple sclerosis. Ferguson. Queen’s Univ., Canada. O. Pucci, A. Battisti-Charbonney, J. Fierstra, D.M. Mandell, B179 1123.3 Nesfatin-1 influences the excitability of D. Mikulis, J. Poublanc, A. Crawley, J. Fisher and J. Duffin. subfornical organ neurons. M.A. Kuksis, L. Dai and A.V. Univ. of Toronto and Univ. Hlth. Network, Toronto. Ferguson. Queen’s Univ., Canada. B170 1121.4 Cerebrovascular reactivity to carbon dioxide: a B180 1123.4 Intrauterine undernutrition programs the theoretical examination. O. Pucci, A. Battisti-Charbonney, J. hypothalamic proteome of female rats. E.B. Ribeiro, A.P. Fierstra, J. Poublanc, A. Crawley, D.M. Mandell, D. Mikulis, J. Pedroso, A.P. Souza, A.P.S. Dornellas, D. Estadella, C.M.O. Fisher and J. Duffin. Univ. of Toronto and Univ. Hlth. Network, Nascimento, L.M. Oyama, J.C. Rosa and R.L.H. Watanabe. Toronto. Fed. Univ. of São Paulo. B171 1121.5 Role of fibrinogen in traumatic brain injury. N. B181 1123.5 Subfornical organ: a novel site for the actions Muradashvili, R. Tyagi, R.L. Benton and D. Lominadze. Univ. of cholecystokinin. A-S.F. Ahmed, A.V. Ferguson and K.A. of Louisville. Sharkey. Univ. of Calgary and Queen’s Univ., Canada. B172 1121.6 Choroid plexus inorganic phosphate (Pi) B182 1123.6 A monoclonal antibody targetting the FGFR- transport: stress-induced alteration of PiT-1 (Slc20A1) 1c isoform reduces body weight and food intake, which localization. J.L. Renfro, S.L. Parker and A. Bataille. Univ. of is, associated with a suppression of deiodinase 2 mRNA Connecticut. expression in hypothalamic tanycytes. R. Samms, A. Lory, J. B173 1121.7 Aerobic training improves the integrity blood Roberts, A. Warner, S. Sundquis, P. Emmerson, B. Perry, K. brain barrier in spontaneously hypertensive rats. L. Buttler, Tsintzas and F. Ebling. Univ. of Nottingham, Karolinska Inst., M.T. Jordão and L.C. Michelini. Univ. of São Paulo. Eli Lilly and Univ. of Aberdeen. B174 1121.8 Low-dose cadmium exposure upregulates B183 1123.7 Photic stimulation is required to elicit estrogen- glutathione (GSH) synthesis in cultured choroid plexus. A. induced anorexia in rats. K. Mabuchi, A. Takano, Y. Hara, K. Villalobos, R. Young and S. Francis Stuart. Texas A&M Univ. Morimoto and A. Takamata. Nara Women’s Univ, Japan. B184 1123.8 Insulin and glucose stimulation of vasopressin 1122. BRAIN DEVELOPMENT AND AGING and oxytocin release requires glucokinase and PI3 kinase. C.D. Sladek, Z. Song and W. Stevens. Univ. of Colorado Sch. of Poster Med. B185 1123.9 Taste without calories is insufficient to drive Tue. 7:30 am—Boston Convention & Exhibition Center, conditioned flavor preferences.J.M. Stratford and T.E. Finger. T Exhibit Halls A-B Univ. Colorado Denver Anschutz Med. Campus. U
Presentation time: 12:45 pm-3:00 pm B186 1123.10 Orchiectomy increases food intake and E perifornical orexin A neuron’s activity during glucoprivation. A. B175 1122.1 Lactational DEHP exposure-impaired motor Takamata, K. Miyake, K. Mabuchi and K. Morimoto. Nara coordination and motor skill learning in adolescent rats. S-C. Women’s Univ, Japan. Yueh, R-C. Yang and D-C. Wang. Kaohsiung Med. Univ., B187 1123.11 Insulin-induced increase in intracellular Taiwan. calcium in the supraoptic nucleus neurons requires activation B176 1122.2 Microglia display distinct sex-dependent of PI3 kinase. Z. Song, W. Stevens and C.D. Sladek. Univ. of gene expression profiles in the postnatal and adult CNS.M. Colorado Sch. of Med. Nikodemova, J. Crain and J.J. Watters. Univ. of Wisconsin- B188 1123.12 Hypophysectomy attenuates leptin-induced Madison. tachycardia without affecting leptin’s action on appetite and body weight. A.A. da Silva, Z. Wang, J.E. Hall and J.M. do Carmo. Univ. of Mississippi Med. Ctr. B189 1123.13 Adiponectin receptor mediated weight regulation: an inflammation-independent mechanism? Z.A.P. Wintrob, H. Radpasand, M.H. Elmeshad, A. Barima, J.L. Rabey, K.A. Chmiel, Z.S. Fayazi, L. Otvos, E. Surmacz, S. Faitar and A.C. Ceacareanu. Univ. at Buffalo, D’Youville Col., NY and Temple Univ. and Sbarro Inst. for Cancer Res.
387 PHYSIOLOGY TUESDAY
1124. COGNITION AND BEHAVIOR 1125. PERIPHERAL CIRCULATION
Poster Poster
Tue. 7:30 am—Boston Convention & Exhibition Center, Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Exhibit Halls A-B
Presentation time: 12:45 pm-3:00 pm Presentation time: 12:45 pm-3:00 pm B190 1124.1 Correlation and causation: systems level B200 1125.1 Heterogeneous vasodilator pathways understanding of decision-making signals at the single-neuronal underlying flow mediated dilation are preserved in healthy level in the human brain. S.R. Patel, S. Sheth, M. Mian, S. aging. K.D. Ballard, M.E. Tschakovsky, A.L. Zaleski, D.M. Bourne, A. Flaherty and E. Eskandar. Massachusetts Gen. Polk, P.D. Thompson, F.J. Kiernan and B.A. Parker. Hartford Hosp. Hosp., CT, Sch. of Kinesiol. and Hlth. Studies, Queen’s Univ., B191 1124.2 Avoidance of environmental gas irritants Canada and Univ. of Hartford. mediated by TRPA1. T. Yonemitsu, N. Takahashi, Y. Mori, B201 1125.2 High dietary sodium reduces flow mediated Y. Kanmura and T. Kuwaki. Grad. Sch. of Med. Dent. Sci. dilation similarly in humans with salt sensitive and salt resistant Kagoshima Univ. and Grad. Sch. of Engin., Kyoto Univ. blood pressure. E.L. Matthews, J.J. DuPont, J.L. Greaney, B192 1124.3 Less exercise, more effects: enhancement S.L. Lennon-Edwards, D.G. Edwards and W.B. Farquhar. of cognitive functions associated with hippocampal BDNF Univ. of Delaware. signaling by voluntary resistance wheel running in adult rats. B202 1125.3 Role of forearm vasoconstriction in the M.C. Lee, Y.F. Liu, K. Inoue, M. Okamoto and H. Soya. Inst. development of primary Raynaud’s disease. Z. Hussain, G. for Hlth. and Sports Sci., Tsukuba, Japan. Ball and J.E. Davis. Alma Col., MI. B193 1124.4 Omega-3 fatty acid supplementation improves B203 1125.4 Sensitivity of forearm critical power to acute adaptive coping in a rat model of post-partum depression. E.M. manipulation of perfusion pressure. J. M. Kellawan, R.F. Gonzales, D.W. Barrett, F. Gonzalez-Lima and M.A. Lane. Bentley, J.J. Walsh, J.S. Moynes and M.E. Tschakovsky. Texas State Univ., San Marcos and Univ. of Texas at Austin. Sch. of Kinesiol and Hlth. Studies, Queen’s Univ., Canada. B194 1124.5 Stress and immune function of social drinking B204 1125.5 Contributions of cyclooxygenase and NO college students before and after spring break. S. Sharma, K. synthase pathways to endothelium-dependent dilatation in the Howard, R. Graham and N. Ceballos. Texas State Univ.-San finger of women.J.M. Marshall. Univ. of Birmingham, U.K. Marcos. B205 1125.6 Individual vasodilatory response heterogeneity B195 1124.6 Decreased neurogenesis in the dentate gyrus during progressive forearm exercise: evidence for vasodilator following sensory non-normative overstimulation. J.S.B. phenotypes. R.F. Bentley, J.M. Kellawan, J.S. Moynes, V.J. Ramirez, D.A. Christakis, R.D. Hodge, R.F. Hevner, A.F. Poitras, J.J. Walsh and M.E. Tschakovsky. Sch. of Kinesiol. Smith, T.K-M. Ramirez, M.F. Burgos and J.M. Ramirez. and Hlth. Studies, Queen’s Univ., Canada. Seattle Children’s Res. Inst., Univ. of Washington and Univ. of B206 1125.7 Pro-atherogenic blood flow and shear patterns Chicago. acutely induce the release of CD62E+ and CD31+/CD42b- B196 1124.7 Behavioral profile assessment in offspring endothelial microparticles in humans. N.T. Jenkins, J. Padilla, of Swiss mice underwent to neonatal treatment with L. Boyle, D.P. Credeur, M.H. Laughlin and P.J. Fadel. Univ. of D-fenfluramine. R.L. Melo, A.L.B. Silveira, F.A.C. Seara, F.F. Missouri-Columbia. Rocha, L.C. Reis and W.S. Cortes. Fed. Rural Univ. of Rio de B207 1125.8 Carotid artery intima-media echogenicity and Janeiro, Seropédica. aortic stiffness in healthy middle-aged and older humans. B197 1124.8 Behavioral profile assessment in offspring of K. Aizawa, S. Elyas, D.D. Adingupu, F. Casanova, K.M. Swiss mice treated during pregnancy and lactation with caffeine. Gooding, D.M. Mawson, A.C. Shore, W.D. Strain and P.E. A.L.B. Silveira, R.L. Melo, F.A.C. Seara, C.S. Almeida, F.F. Gates. Univ. of Exeter Med. Sch., U.K. Rocha, A.S.N. Santos, B.G. Marinho, L.C. Reis and W.S. B208 1125.9 Lower potassium intake is associated with Cortes. Fed. Rural Univ. of Rio de Janeiro, Seropédica. increased wave reflection in young healthy males.S. Lennon- B198 1124.9 Perinatal exposure to low levels of carbon Edwards, T. Schellhardt, B. Allman, W.B. Farquhar and D.G. monoxide impairs neurobehavior in adult mice. J.T. O’Neill, Edwards. Univ. of Delaware. M.L. Kehl, K.P. Johnson, K. Cravedi, E.S. Barry and N.E. B209 1125.10 Mitochondria-targeted antioxidant therapy Grunberg. Uniformed Svcs. Univ. of Hlth. Sci. with MitoQ ameliorates age-related vascular endothelial B199 1124.10 Comparison of floor aerobics and treadmill dysfunction. R.A. Gioscia-Ryan, T.J. LaRocca, M.C. Zigler, walking on cognitive changes and participant satisfaction. J. M.P. Murphy and D.R. Seals. Univ. of Colorado Boulder and Larsen, C-L. Hansen, M. Schmitter-Edgecombe and J. Univ. of Cambridge. Knuth. Washington State Univ. B210 1125.11 Model predictions of arterial adaptation to steady-flow left ventricular assist devices. P.H. Nguyen, E. Tuzun, S.F. Knezek, M.W. Mohiuddin and C.M. Quick. Michael E. DeBakey Inst. and Texas A&M Inst. for Preclin. Studies.
388 TUESDAY PHYSIOLOGY
1126. CARDIAC FUNCTION AND DYNAMICS I 1127. ENDOTHELIAL CELL BIOLOGY III
Poster Poster
Tue. 7:30 am—Boston Convention & Exhibition Center, Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Exhibit Halls A-B
Presentation time: 12:45 pm-3:00 pm Presentation time: 12:45 pm-3:00 pm B211 1126.1 Is myocardial iron content associated B222 1127.1 Protease-activated receptor-3 signals with left atrial systolic function in asymptomatic hereditary independent of protease-activated receptor-1 to regulate hemochromatosis? Y. Shizukuda, D. Tripodi, V. Sachdev, C. endothelial nitric oxide synthase in human endothelial cells. Brenneman, S. Sidenko, M. St. Peter, C. Bolan, Y.Y. Yau, A. L.C. Tillery and E. Motley-Johnson. Meharry Med. Col. Arai, P. Bandettini, S. Leitman and D. Rosing. NHLBI, NIH, B223 1127.2 Sex differences in aortic endothelial function Univ. of Cincinnati and NIH Clin. Ctr. of streptozotocin-induced diabetic rats: a possible role of B212 1126.2 Epicardial force and strain measurements from superoxide production. X. Han, R. Zhang, L. Anderson and R. the in vivo murine heart. C. Constantinides, M. Michaelides Rahimian. Univ. of Pacific. and S. Georgiadou. Univ. of Cyprus, Cyprus and Natl. B224 1127.3 L-leucine inhibits nitric oxide synthesis in Reference Lab. for Animal Hlth., Cyprus. endothelial cells. Y. Yang, C. Meininger, K. Kelly, Z. Wu, F. B213 1126.3 Longitudinal assessment of systolic and Bazer and G. Wu. Texas A&M Univ. diastolic function using conventional and speckle tracking B225 1127.4 Physiologic cyclic strain stimulates heme echocardiography following acute ischemia and prolonged oxygenase-1 gene expression in endothelial cells: role in cell reperfusion in the rat. W. Bao, F. Wright, Z. Ao, R.C. Mirabile, survival and proliferation. W. Durante, X-m. Liu and K.J. K.S. Frazier, R.W. Coatney, C.G. Schnackenberg and B.M. Peyton. Univ. of Missouri-Columbia. Jucker. GlaxoSmithKline. B226 1127.5 b-Arrestin-mediated signal transduction B214 1126.4 Measurement of heart function for myocardial participates in laminar shear stress-induced production of nitric infarction model of rat by microCT. S. Matsushita, M. Naito oxide in endothelial cells. A.P.C. dos Santos, V.G. Barauna, and A. Amano. Juntendo Univ., Japan. M.H.F. Alaniz, A.C.C. Girardi and J.E. Krieger. Univ. of São B215 1126.5 Cardiovascular response to an inhaled Paulo Med. Sch. b-agonist in patients with heart failure: effect of b-blockade. B227 1127.6 Endothelial cells from different vascular bed M. Martinez, S.E. Baker, B. Taylor, B.D. Johnson and E.M. respond to secondhand smoke differently under dynamic shear Snyder. Univ. of Arizona, Mayo Clin. and Univ. of Minnesota, stress. W. Yin, E.C. Ngwe and D.A. Rubenstein. Oklahoma Minneapolis. State Univ. B216 1126.6 Interaction of mitofilin with respiratory B228 1127.7 Disturbed flow increases caveolae-mediated complexes in mitochondrial subpopulations. D. Thapa, R. oxLDL uptake in endothelial cells. E. LeMaster, S. Sun, V. Jagannathan, T.L. Croston, W.A. Baseler, C.E. Nichols, D.L. Shinin, D. Eddington, M. Cho, R. Minshall and I. Levitan. Shepherd, S.E. Lewis and J.M. Hollander. West Virginia Univ. Univ. of Illinois at Chicago. B217 1126.7 Age dependency of autonomic response to B229 1127.8 20-HETE activates endothelial ACE via an IKK/ recumbent positions. R. Sato, K. Sasaki, M. Haga, H. Sato, Y. NF-kB dependent pathway. V.G. Garcia, L. Milhau, J.R. Falck Kimura, E. Kanno and R. Maruyama. Tohoku Univ. Grad. Sch. and M.L. Schwartzman. New York Med. Col., Fac. of Pharm., of Med., Japan and Univ. of Tokyo Hosp. Montpellier, France and Univ. of Texas Southwestern Med. Ctr. B218 1126.8 A rat model of doxorubicin-induced late-onset B230 1127.9 Tachycardia promotes mitochondrial DNA cardiotoxicity. N.M. Gibson, C-Y. Lien, B.T. Jensen, D.S. damage by JNK translocation to mitochondria. N. Jen, R. Li Hydock and R. Hayward. Univ. of Northern Colorado, Taiwan and T. Hsiai. Univ. of Southern California. Natl. Univ. and Slippery Rock Univ. B219 1126.9 Endovascular dual-sensor composite sensor 1128. INFLAMMATION AS AN ORCHESTRATOR IN T catheter for the measurement of flow and pressure in rats using HEART FAILURE (POSTERS) U telemetry. K. Pitsillides, M. Lin, L. Griffiths, D. Uyeminami, K. E Johnson and K. Pinkerton. Transonic EndoGear Inc., Davis Poster and Univ. of California, Davis. B220 1126.10 Oxidative stress level mediates the inotropic Tue. 7:30 am—Boston Convention & Exhibition Center, effects of alcohol on the heart. M. AlRubaiee, N. Umoh, M. Exhibit Halls A-B Jeffress, R. Walker, V. Cousins and G.E. Haddad. Howard Presentation time: 12:45 pm-3:00 pm Univ. B221 1126.11 Ursolic acid potentiates muscarinic receptor- B231 1128.1 The role of TNF-a in cardioprotection induced induced ANP secretion in perfused beating rat atria. H.Y. Kim, by adaptation to chronic hypoxia in rats. J. Neckar, A. Chytilova, O.J. Kwon, J.H. Kho, R. Tan, K.W. Cho, D.G. Kang and H.S. G.H. Borchert and F. Kolar. Inst. of Physiol. Acad. of Sci. of Lee. Wonkwang Univ., South Korea. Czech Republic, Prague. B232 1128.2 Thromboxane A2 mediates apoptosis in cardiomyocytes via IP3. C.D. Touchberry, C.J. Elmore, S. Srinivas and M.J. Wacker. Sch. of Med., Univ. of Missouri- Kansas City. B233 1128.3 Gene expression profiling in the rat infarcted heart in response to antioxidant treatment. W. Zhao, T. Zhao, Y. Chen, Y. Qu, I.C. Gerling, K.T. Weber and Y. Sun. Univ. of Tennessee, Memphis.
389 PHYSIOLOGY TUESDAY
B234 1128.4 The protection of urocortin 2 against ischemia/ B247 1128.17 Nicotine reduced post-infarct inflammation and reperfusion injury is due to p38 MAPK downregulation in an improved cardiac output during exercise in conscious mice. isolated rat heart model. Y. Zhou, X. Gao, D. Wang, K. Lew, H.L. Lujan, R. Wang, A.J. Blumberg and S.E. DiCarlo. Wayne A. Richards and P. Wang. Natl. Univ. of Singapore, Huashan State Univ. Sch. of Med. Hosp., Shanghai and Putuo Hosp., Shanghai. B248 1128.18 Epidermal growth factor receptor-tyrosine B235 1128.5 Crosstalk between Toll-like receptor 4 and kinase inhibition by erlotinib causes hypomagnesemia, interleukin 10 in cardiomyocyte survival. A.K. Bagchi, A. oxidative stress and cardiac dysfunction. W.B. Weglicki, I.T. Sharma, G. Akolkar and P.K. Singal. St. Boniface Res. Ctr., Mak, J.J. Chmielinska, C.F. Spurney and J.H. Kramer. The Univ. of Manitoba. George Washington Univ. and Children’s Natl. Med. Ctr. B236 1128.6 CD40-CD40 ligand (CD40L) signaling modulates cardiac hypertrophy in angiotensin-IIi induced 1129. MATRIX METALLOPROTEINASES IN THE hypertensive heart disease. W. Derks, E. Lutgens, M. van CARDIOVASCULAR SYSTEM (POSTERS) Bilsen and S. Heymans. Maastricht Univ. and Acad. Med. Ctr., Amsterdam. Poster B237 1128.7 Thromboxane A2 mimetic, U46619, does not induce markers of pathological hypertrophy in cardiomyocytes. Tue. 7:30 am—Boston Convention & Exhibition Center, M.J. Wacker, V. Tchikrizov, H.K. Swan, L.A. Wetmore and Exhibit Halls A-B C.D. Touchberry. Sch. of Med., Univ. of Missouri-Kansas City Presentation time: 12:45 pm-3:00 pm and William Jewell Col., MO. B238 1128.8 Osteonectin protects against adverse cardiac B249 1129.1 S100A4 is a key regulator of matrix inflammation during viral myocarditis. A. Papageorgiou, metalloproteinases expression in vascular smooth muscle M. Rienks, D. Vanhoutte, W. Verhesen, P. Carai, T. cells. V. Lemaitre, J-A. Weir and H. Miura. Univ. of Nevada, Vandendriessche, M. Chuah and S. Heymans. Maastricht Reno. Univ., Netherlands, Univ. Leuven, Belgium and Cincinnati B250 1129.2 Selective upregulation of genes for MMP3 and Children’s Hosp. Med. Ctr. MT-1 MMP by substance P in cardiac fibroblasts.H.M. Dehlin, B239 1128.9 The role of inflammatory responses in alcoholic A. Monroe, M. Reimer, E. Manteufel and S. Levick. Med. Col. cardiomyopathy. R.K. Walker and G.E. Haddad. Howard Univ. of Wisconsin. B240 1128.10 Cannabinoid 1 receptor promotes cardiac B251 1129.3 Ablation of MMP9 ameliorates epigenetic dysfunction, oxidative stress, inflammation, and fibrosis in modifications and mitigates diabetic cardiomyopathy.P.K. diabetic cardiomyopathy. P. Pacher, M. Rajesh, S. Batkai, P. Mishra, V. Chavali, N. Metreveli and S.C. Tyagi. Univ. of Mukhopadhyay, W-S. Lee, B. Horvath, R. Cinar, L. Liaudet, Louisville. K. Mackie and G. Haskó. NIAAA, NIH, Rockville, Univ. Hosp., B252 1129.4 MMP-9 dependent proteins regulate left Lausanne, Indiana Univ. and UMDNJ-New Jersey Med. Sch., ventricular remodeling following myocardial infarction. L.E. Newark. de Castro Bras, K.Y. DeLeon, A. Yabluchanskiy, Y. Ma, B241 1128.11 Circulating inflammatory mediators as potential G.V. Halade, K. Hakala, S.T. Weintraub and M.L. Lindsey. biomarkers for heart failure: a study of the baseline levels in Univ. of Texas Hlth. Sci. Ctr. at San Antonio and San Antonio healthy volunteers. R. Altara, M.H.M. Hessel, M. Manca, H.P. Cardiovasc. Proteomics Ctr. Brunner-La Rocca, A.P.M. Gorgels, R.J.J. Hermans, B.J.A. B253 1129.5 Endurance exercise training attenuates fibrosis Janssen, H.A.J. Struijker Boudier and M.W. Blankesteijn. and collagen cross-linking in myocardium of aged F344BNF1 Maastricht Univ., Netherlands. rats. K.J. Wright, A. Betik, M. Thomas, R. Hepple and D. B242 1128.12 Prohibitin coordinates an anti-inflammatory/ Belke. McGill Univ., Victoria Univ., Australia, McMaster Univ. antioxidant feedback loop from mitochondria to nucleus to and Univ. of Calgary, Canada. protect the heart from severe inflammatory stress.T.A. Mattox, B254 1129.6 Cardiac fibrosis and diastolic dysfunction are K.A. Thayne and E.J. Anderson. Brody Sch. of Med. at East highly correlated in a mouse chronic pressure-overload model. Carolina Univ. A. Olzinski, W. Bao, D. DeLong, S. Lenhard, F. Wright, R. B243 1128.13 Differential response of cardiac NOX-2 and -4 Coatney, B. Jucker, S. Eisennagel, S. Needle, T. Wang and to mild and severe pressure overload. J.M. Bradley, M.C. El C. Schnackenberg. GlaxoSmithKline. Hajj, A.J. Mouton, E.C. El Hajj and J.D. Gardner. LSU Hlth. B255 1129.7 Both collagen and elastin matrices are Sci. Ctr., New Orleans. remodeled in the failing ovine atria – a role for elastin- B244 1128.14 Circulating Porphyromonas gingivalis degrading enzymes in atrial structural remodeling. M.A. Horn, lipopolysaccharide induces left ventricular dysfunction through H.K. Graham, S.J. Borland, J.D. Clarke, K.M. Dibb and A.W. MMP-9 regulation of inflammation. K.Y. DeLeon, L.E. de Trafford. Univ. of Manchester. Castro Bras, J. Zhang and M.L. Lindsey. Univ. of Texas Hlth. B256 1129.8 Activation of proteases and changes in Na+-K+ Sci. Ctr. at San Antonio. ATPase subunits in hearts subjected to ischemia-reperfusion. B245 1128.15 Lysyl oxidase inhibition in the volume overloaded A.L. Müller, D.H. Freed and N.S. Dhalla. Univ. of Manitoba. heart prevents adverse collagen remodeling, apoptosis, and B257 1129.9 Doxycycline attenuates cardiac injury and cardiac dysfunction. M.C. El Hajj, T.G. Voloshenyuk, M.A. improves cardiac function with inhibition of myocardial matrix Claudino, J.M. Bradley and J.D. Gardner. LSU Hlth. Sci. Ctr., metalloproteinase-2 in a swine model of hypoxia-reoxygenation. New Orleans. J.R. LaBossiere, J-S. Pelletier, M. Ali, D. Bigam, R. Schulz B246 1128.16 The inflammatory mediator SH2B3 increases and P-Y. Cheung. Univ. of Alberta. risk of heart failure. M.J. Flister, C. Moreno, M.J. Hoffman, B258 1129.10 Analysis of mitochondrial MMP-2 and MMP-9 S.Z. Prisco, J. Lazar, J.L. Hall and H.J. Jacob. Med. Col. of in the heart. B. Hughes, F. Fan, T. Simmen and R. Schulz. Wisconsin and Univ. of Minnesota, Minneapolis. Univ. of Alberta.
390 TUESDAY PHYSIOLOGY
B259 1129.11 The increase of mitochondrial DNA copy B270 1130.4 Mechanical tissue resuscitation activates the number attenuates eccentric cardiac remodeling in volume risk pathway and widens the therapeutic window for treating overload model. M. Ikeda, T. Ide, T. Fujino, Y. Hata, T. Takehara, acute myocardial infarction. J.E. Jordan, B.D. Pereira, M.J. K. Onitsuka, T. Tobushi, K. Sakamoto, K. Saku, T. Kakino, Morykwas, M.R. Lane, J.J. Mays, G. Colmer, C. Hollingsworth H. Tyynismaa, A. Suomalainen and K. Sunagawa. Kyushu and L.C. Argenta. Wake Forest Sch. of Med. Univ., Japan and Univ. of Helsinki. B271 1130.5 Evidence for pleiotropic cardioprotection by B260 1129.12 Molecular mechanisms of PDGF-D-induced the bradycardic agent ivabradine. P. Kleinbongard and G. cardiac fibrogenesis. T. Zhao, W. Zhao, Y. Chen, V.S. Li and Y. Heusch. Univ. Hosp. Essen, Germany. Sun. Univ. of Tennessee Hlth. Sci. Ctr., Memphis. B272 1130.6 Reactive oxygen species in saliva-related B261 1129.13 Identification of novel scleraxis gene targets in acute myocardial infarction. M.C. Rubio, S. Puntarulo, P. cardiac myofibroblasts.R. Bagchi, P. Roche, R. Schweitzer Gonzalez, C. Ramos, P. Lewin, F. Lifshitz, S. Friedman and and M. Czubryt. Univ. of Manitoba and Oregon Hlth. & Sci. L. Nicolosi. Sch. of Dent., Hosp. Español., PRALIB, CONICET, Univ. Sch. of Pharm. and Biochem., Univ. of Buenos Aires and Pediat. B262 1129.14 Autophagy in phenoconversion of differentiated Sunshine Acad. & Sansum Med. Res Inst., Santa Barbara. and undifferentiated fibroblasts. S. Gupta, M. Kavosh, S-R. B273 1130.7 Low-dose intra-nasal cocaine causes Chen, S. Ghavami, S. Rattan, T. Klonisch and I. Dixon. Univ. subclinical microvascular coronary ischemia in humans. M. of Manitoba. Nelson, S.V. Gurudevan, X. Tang, J. Lewis, J. Johannes, T. B263 1129.15 The passive mechanical environment alters Belcik, J.R. Lindner and R.G. Victor. Cedars-Sinai Med. Ctr. the phenotype of cardiac fibroblasts. M. Galantowicz, T.A. and Oregon Hlth. & Sci. Univ. West, X. Zhang, R.C. Childers, K.J. Gooch, J.C. Weibel, M.J. B274 1130.8 Hemodynamic and bioenergetics of hearts Cismowski and P.A. Lucchesi. Nationwide Children’s Hosp. from obese adult mice overfed during early life. A.K. Vieira, and The Ohio State Univ. A.M. de Mattos, F.A. Neves, A.F. Bernardo, E.C. Cortez, L.R. B264 1129.16 Anti-parstatin promotes angiogenesis and de Souza, G.L. Miranda, V.M. dos Santos, A.C.S. Rodrigues- ameliorates left ventricular dysfunction during pressure Cunha, É.P. Garcia-Souza, R. Sichieri and A.S. Moura. Rio overload. S. Givvimani, N. Narayanan, S.B. Pushpakumar de Janeiro State Univ. and S.C. Tyagi. Univ. of Louisville. B275 1130.9 Reciprocal endothelial NO synthase Ser1177 B265 1129.17 Absence of TRPV4 channels improves cardiac phosphorylation and Thr495 dephosphorylation is key for function and remodeling following myocardial infarction and robust in vivo cardioprotection: therapeutic implication of a transverse aortic constriction. R.K. Adapala, D.J. Luther, V.A. novel ischemic preconditioning stimuli. M.A.H. Talukder, F. Ohanyan, J. Luli, R. Thoppil, S. Paruchuri, W.M. Chilian, J.G. Yang, C. Yang, Y. Nishijima, C-A. Chen, S. Varadharaj and Meszaros and C.K. Thodeti. Northeast Ohio Med. Univ. and J.L. Zweier. Davis Heart and Lung Inst., The Ohio State Univ. Univ. of Akron. B276 1130.10 a1-Adrenergic receptor activation mimics B266 1129.18 Angiotensin II-induced myocardial hypertrophy ischemic postconditioning. D.M. Janota and J. Yun. Northeast and fibrosis are characterized by enhanced MMP-9 and Ohio Med. Univ. and Kent State Univ. suppressed RECK expression. J.M. Siddesha, A.J. Valente, S.S.V.P. Sakamuri and B. Chandrasekar. Tulane Univ. Sch. of 1131. NOVEL SIGNALING MOLECULES IN VASCULAR Med., Univ. of Texas Hlth. Sci. Ctr. at San Antonio and Southeast INJURY AND INFLAMMATION (POSTERS) Louisiana Veterans Hlth. Care Syst. Poster 1130. MYOCARDIAL ISCHEMIA/MYOCARDIAL METABOLISM I Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B
Poster Presentation time: 12:45 pm-3:00 pm T Tue. 7:30 am—Boston Convention & Exhibition Center, B277 1131.1 Telomere uncapping causes cellular Exhibit Halls A-B senescence and inflammation in arteries: implications for U arterial aging. R.G. Morgan, S.J. Ives, L.A. Lesniewski, E Presentation time: 12:45 pm-3:00 pm R.M. Cawthon, R.H.I. Andtbacka, R.D. Noyes, E.L. Denchi, B267 1130.1 Mechanical tissue resuscitation reduces R.S. Richardson and A.J. Donato. Univ. of Utah, George E. myocardial tissue injury following myocardial ischemia- Wahlen DVA Med. Ctr. and The Scripps Res. Inst. reperfusion. J.E. Jordan, J.J. Mays, J.E. Shelton, E.A. B278 1131.2 Ga13 targeting of VE-cadherin mediates Thompson, A.K. Bryant, M.R. Lane and M.J. Morykwas. disassembly of adherens junctions and endothelial permeability. Wake Forest Sch. of Med. H. Gong, X. Gao, M.R. Siddiqui, A. Garcia, M. Bonini, S.M. B268 1130.2 The roles of mitochondrial Src tyrosine kinase Vogel and A.B. Malik. Univ. of Illinois at Chicago. and zinc in nitric oxide-induced cardioprotection against B279 1131.3 Stathmin modulates microtubule dynamics ischemia/reperfusion injury. Z. Xu, X. Liu, L. Zhang, Y. Kang, J. and controls Rho signaling and vascular permeability. A.A. Lou and Y. Zhu. Tianjin Med. Univ., China. Birukova, N. Sarich, T. Wu and X. Tian. Univ. of Chicago. B269 1130.3 Novel fatty acyl CoA synthetase inhibitors – B280 1131.4 Novel Rap1-dependent regulator of endothelial new tools to study ischemia/reperfusion injury. N.R. Blakeman, cell junctions afadin mediates protective effects by oxidized A.M. Prior, L. Pokhrel, D.H. Hua and M.T. Weis. Sch. of phospholipids in the models of acute lung injury. K.G. Birukov, Pharm., Texas Tech Univ. Hlth. Sci. Ctr. and Kansas State Univ. N. Sarich, O. Dubrovskyi and N. Zebda. Univ. of Chicago.
391 PHYSIOLOGY TUESDAY
B281 1131.5 LPS induces pp60c-srcmediated tyrosine 1132. EXERCISE TRAINING RESPONSES phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung. N. Barabutis, V. Handa, C. Dimitropoulou, Poster R. Rafikov, C. Snead, S. Kumar, A. Joshi, G. Thangjam, D. Fulton, S.M. Black, V. Patel and J.D. Catravas. Georgia Hlth. Tue. 7:30 am—Boston Convention & Exhibition Center, Sci. Univ. Exhibit Halls A-B B282 1131.6 Post-treatment with the heat shock protein 90 Presentation time: 12:45 pm-3:00 pm inhibitor, 17-AAG, reduces pulmonary inflammation, hyper- permeability and airway dysfunction associated with LPS- B295 1132.1 Applying lactate sampling to interval training in induced acute lung injury in mice. C. Dimitropoulou, A. Joshi, CAD. J.W. Christle, A. Pressler, U. Wisloff and M. Halle. Tech N. Barabutis, M. Shaw, V. Patel and J.D. Catravas. Georgia Univ. Munich and Norwegian Univ. of Sci. and Technol. Hlth. Sci. Univ. B296 1132.2 Gluconeogenesis and hepatic glycogenolysis B283 1131.7 ER stress regulator BiP and mitochondrial during exercise at the lactate threshold. C-A.W. Emhoff, L.A. chaperone mortalin differentially regulate RelA/p65 activation Messonnier, M.A. Horning, J.A. Fattor, T.J. Carlson and and endothelial cell inflammation. A. Leonard, A. Rahman and G.A. Brooks. Univ. of California, Berkeley and Univ. de Savoie, F. Fazal. Univ. of Rochester Med. Ctr. France. B284 1131.8 Regenerative cerebral arteriogenesis is B297 1132.3 Effects of aging and low-load balance exercise induced by GM-CSF and inhibited by anti-inflammatory on the expression of neurotrophins and glutamate receptors in cardiovascular medications. A.B. Persson, A. Duelsner, N. the mouse brain. H. Maejima, N. Kanemura, T. Kokubun, K. Gatzke and I.R. Buschmann. Charité Univ. Hosp. Berlin. Murata and K. Takayanagi. Teikyo Univ. of Sci. and Saitama B285 1131.9 Role of sphingolipids in fibrinogen-induced Prefect. Univ., Japan. cerebrovascular permeability. N. Muradashvili, S.J. B298 1132.4 Determination of exercise modality employing Khundmiri, R. Tyagi, M-J. Lee and D. Lominadze. Univ. of serum metabolomics profiling in type 2 diabetes: relation to Louisville and Wayne State Univ. clinical outcomes. J.J. Yang, M. Palmnas, J. Su, L. Kirtiadi, H. B286 1131.10 Novel mitochondrial mechanisms mediate Vogel, R. Sigal and J. Shearer. Univ. of Calgary, Canada. enhanced vasodilation of rat middle cerebral arteries to B299 1132.5 Muscle perilipin 3 is reduced using in vitro and mitochondrial depolarization following ischemia-reperfusion in vivo exercise models and negatively associated with exercise injury. I. Rutkai, E.A. Wappler, P.V.G. Katakam, D. Liu and lipid oxidation. J.D. Covington, J.E. Galgani, A.C. Rustan, Z. D.W. Busija. Tulane Univ. Sch. of Med. Zhang, C. Moro, S.R. Smith, E. Ravussin and S. Bajpeyi. B287 1131.11 Activation of formyl peptide receptors induces Pennington Biomed. Res. Ctr., Baton Rouge, Pontifical Catholic relaxation and reduces contraction in resistance arteries. C.F. Univ. of Chile, Univ. of Oslo, Inst. of Metab. and Cardiovasc. Wenceslau, C.G. McCarthy, S. Goulopoulou and R.C. Webb. Dis., Toulouse, Florida Hosp.-TRI, Orlando and Univ. of Texas Georgia Hlth. Sci. Univ. at El Paso. B288 1131.12 Connexin 40 is necessary for recovery of B300 1132.6 Low volume high intensity training improves ischemic hindlimb perfusion—inflammation and gender insulin sensitivity but reduces aerobic power in trained middle- considerations. J.M. Burt, L.L. Querin, J.R. Oulton and J.S. aged runners. K. Winding, L.S. Hansen, T.A. Knudsen, Y. Fang. Univ. of Arizona. Hellsten, S.P. Mortensen and B.K. Pedersen. Copenhagen B289 1131.13 FoxO induced inhibition of secreted molecule Univ. Hosp. and Univ. of Copenhagen. signaling pathways: role in promoting angiostasis in the B301 1132.7 Low-volume high intensity interval training ischemic muscle. E.A. Roudier, M. Milkiewicz and T.L. Haas. induces a modest inflammatory response in young active York Univ., Canada and Pomeranian Med. Univ., Poland. males. C.S. John, M.M. Lawrence, R.A. Shanely, R.A. B290 1131.14 Intravenous infusion of Bendavia during renal Battista and K.A. Zwetsloot. Appalachian State Univ., Boone revascularization attenuates cardiac injury and dysfunction in and Kannapolis, NC. swine renovascular hypertension. B.J. Williams, A. Eirin, B. B302 1132.8 Effects of resistance interval and constant Ebrahimi, X. Zhang, J.R. Woollard, H. Tang, K.L. Jordan, J.A. training on muscular hemodynamic kinetics in sedentary men. Crane, A. Lerman and L.O. Lerman. Mayo Clin. and Univ. of C-L. Chiang and J-S. Wang. Natl. Taiwan Sport Univ. and California, Irvine Sch. of Med. Chang Gung Univ., Taiwan. B291 1131.15 Myloid differentiation factor 88 does not B303 1132.9 Resistance exercise training reverses age- contribute to hypertension or endothelial dysfunction produced related impairments in macro- and microvascular blood flow by angiotensin II. J.R. Gomolak, J.L. Faulkner and S.P. and the associated blunted muscle protein synthesis response Didion. Univ. of Mississippi Med Ctr. to nutrition. B. Phillips, P. Atherton, K. Varadhan, M. Limb, M. B292 1131.16 Antagonistic effects of mineralocorticoid Rennie, K. Smith and J. Williams. Sch. of Grad. Entry Med. receptor blockade on the vascular reactivity of male and female and Hlth. and Sch. of Biomed. Sci., Univ. of Nottingham. leptin-sensitized mice. A-C. Huby, M.L. Tremblay and E.J. B304 1132.10 Basal expression of VEGF does not correlate Belin de Chantemele. Georgia Hlth. Sci. Univ. and McGill Univ. with loss of skeletal muscle capillarity with detraining. S. B293 1131.17 Immune cell-mediated regulation of lymphatic Olenich, K. Roberts, G. Audet and I.M. Olfert. West Virginia contractility during inflammation.S. Chakraborty, W. Wang, Univ. D.C. Zawieja and M. Muthuchamy. Col. of Med., Texas A&M B305 1132.11 Effect of aerobic interval training on erythrocyte Hlth. Sci. Ctr. rheological and hemodynamic functions in heart failure patients B294 1131.18 PPARg-mediated modulation of acrolein- with anemia. J-S. Wang. Chang Gung Univ., Taiwan. induced oxidative stress: role of NAD(P)H oxidase subunit B306 1132.12 Effect of combined aerobic and resistance gp91phox. N. Chug, K. Marek, Z. Yousefipour and M. Newaz. exercise training on platelet adhesiveness under shear flow in Chicago State Univ. and Texas Southern Univ. sedentary men. Y-C. Chen and J-S. Wang. Chang Gung Univ., Taiwan.
392 TUESDAY PHYSIOLOGY
B307 1132.13 Effects of combined aerobic and resistance B322 1132.28 Impact of exercise training on cardiovascular exercise training on apoptosis and autophagy of CD4+ risk and anti-risk factors in adolescent boys. M. Koozehchian, lymphocytes in sedentary men. Y-H. Lin and J--S. Wang. F. Nazem and R.B. Kreider. Texas A&M Univ. and Bu Ali Sina Chang Gung Univ., Taiwan. Univ., Iran. B308 1132.14 Effect of combined aerobic and resistance B323 1132.29 Enhanced spontaneous cage activity induced exercise training on circulating progenitor cells in sedentary by continuous low intensity spinal cord epidural stimulation in men. C-P. Lin and J-S. Wang. Chang Gung Univ., Taiwan. complete spinal cord transected adult rats. P. Gad, J. Choe, M. B309 1132.15 Aerobic interval training improves mobilization Rath, P. Shah, Y. Gerasimenko, H. Zhong, R.R. Roy and V.R. and migratory capacity of endothelial progenitor cells in Edgerton. UCLA. sedentary men. H-H. Tsai and J-S. Wang. Chang Gung Univ., B324 1132.30 Effect of unilateral E-stim on strength in a Taiwan. contralateral untrained limb after bilateral strength training. S. B310 1132.16 Hospital-based supervised aerobic training LoRusso, N. Barr, W. Hanik, J. Hazen, A. Strittmatter and T. effectively improves ventilation efficiency and cardiac output Tocco. Saint Francis Univ., PA. power in patients with systolic heart failure. C-W. Ho, S-C. B325 1132.31 The changes of lower limb muscle function and Huang, S-C. Cheng, C-H. Chan and J-S. Wang. Chang Gung gait with application of aquatic rehabilitation exercise in Korean Univ., Taiwan. stroke patients. H.M. Jin, I.G. Jeon and H.E. Kim. Kyonggi B311 1132.17 Different physiological adaptations to aerobic Univ. and Dong-eui Univ., South Korea. interval training between heart failure patients with reduced B326 1132.32 Endurance training promotes upregulation in and preserved ejection fractures. T-C. Fu and J-S. Wang. microRNA-206 on blood and in human skeletal muscle. C.R. Chang Gung Memory Hosp. and Chang Gung Univ., Taiwan. Alves, J.R.L. Junior, G.B. Alves, C.E. Negrão and E.M. B312 1132.18 Effects of obesity and exercise training on Oliveira. Univ. of São Paulo, Heart Inst. and Sch. of Phys. testosterone levels in male rats. N. Arsenis, B. Disanzo and Educ.and Sport. T. You. Univ. of Massachusetts Boston and Univ. at Buffalo, B327 1132.33 Influence of sprint interval training on skeletal SUNY. muscle mitochondria as determined by high-resolution B313 1132.19 The effects of combined exercise on body respirometry. J.W. Beals, C.H. Le, R.L. Scalzo, S.E. Binns, compositions and blood lipid profiles in Korean obese women. G.R. Giordano, A.L. Klochak, H.L. Paris, K.E. Sevits, C. Bell H.M. Jin and P.J. Kim. Grad. Sch. of Sport Sci., Kyonggi Univ., and A.J. Chicco. Colorado State Univ. South Korea. B314 1132.20 Adipose tissue decrease by exercise training 1133. MICROVASCULAR RESPONSES AND is associated with blood pressure reduction in old fructose-fed THERMOREGULATORY CONTROL IN NORMAL female rats. J.F. Machi, N. Bernardes, D.S. Dias, F. Santos, AND CLINICAL POPULATIONS (POSTERS) I.C. Moraes-Silva, M. Sartori, R.B. Wichi, K. De Angelis and M.C. Irigoyen. Heart Inst. and Fac. of Med., Univ. of São Paulo, Poster Nove de Julho Univ., São Paulo and Fed. Univ. of Sergipe, Brazil. Tue. 7:30 am—Boston Convention & Exhibition Center, B315 1132.21 Sex-differences in the effects of isometric Exhibit Halls A-B handgrip training on resting blood pressure and resistance Presentation time: 12:45 pm-3:00 pm vessel function. M.B. Badrov, S.R. Freeman, P.J. Millar and C.L. McGowan. Univ. of Windsor, Canada and Toronto Gen. B328 1133.1 Endothelium-dependent vasodilation in Hosp. young, obese adults: contribution of NOS. G.L. Peltonen, B316 1132.22 Aquatic training reduces exercise blood R.E. Johansson, J.W. Harrell, J.K. Limberg, M.K. Crain, J.J. pressure and increases muscle eNOS. S.F. Crouse, N.P. Sebranek, B.J. Walker, E.W. Marlowe and W.G. Schrage. Greene, B.S. Lambert, A.T. Carradine, D. Joubert, S. Univ. of Wisconsin-Madison. Riechman and J. Fluckey. Texas A&M Univ. and Univ. of B329 1133.2 Reduced contribution of NOS and CO to T Virginia. beta adrenergic vasodilation in obesity. M.K. Crain, R.E. B317 1132.23 Physiological and biomechanical analysis of a Johansson, G.L. Peltonen, J.W. Harrell, W.G. Schrage, J.K. U foot-tapping device. L. Brilla, D.N. Suprak and R. Callahan. Limberg, J.J. Sebranek, B.J. Walker and M.W. Eldridge. E Western Washington Univ. Univ. of Wisconsin-Madison and Univ. of Wisconsin Sch. of B318 1132.24 Modeling exercise effects on cardiovascular Med. and Publ. Hlth. fitness using STELLA. A.C. Sanders and R.T. Davidson. B330 1133.3 Heat production per unit mass determines Logan Univ., MO. the core temperature response to exercise in compensable B319 1132.25 Block periodization training in Navy SEAL conditions. M.N. Cramer and O. Jay. Univ. of Ottawa Sch. of Operators: effect of 12 weeks on salivary hormones. J. Oliver, Human Kinet. A.C. Zimmer, D. Wood, J.P. Abt, T.C. Sell and S.M. Lephart. B331 1133.4 Improved thermoregulatory and autonomic Univ. of Pittsburgh and Naval Special Warfare, Pittsburgh. responses contribute to reduced fatigue and faster recovery B320 1132.26 Overall stress response is reduced in U.S. from exertional heat stress by sympatholytic treatment with marines following infantry training. K. Kelly, A. Jensen, B. clonidine. H.M. Stauss, N. Choudhary, A.M. Moss and K.C. Niederberger, R. Congalton and R. Jaworski. Naval Hlth. Kregel. Univ. of Iowa. Res. Ctr., San Diego and Marine Corps Systs. Command, B332 1133.5 Effects of prior exercise on skin blood flow and Quantico, VA. insulation during subsequent moderate cold exposure. M.G. B321 1132.27 Exercise training in childhood cancer survivors Spitz, J.W. Castellani, M.J. Alinovi and D.W. DeGroot. U.S. with subclinical cardiomyopathy. W.A. Smith, K.K. Ness, V.M. Army Res. Inst. of Envrn. Med., Natick, MA and U.S. Army Publ. Joshi, M.M. Hudson, L.L. Robison and D.M. Green. St. Jude Hlth. Command, Aberdeen, MD. Children’s Res. Hosp. and Univ. of Mississippi.
393 PHYSIOLOGY TUESDAY
B333 1133.6 Whole-body sweat sensitivity in burn survivors B348 1134.4 Maternal exercise during pregnancy improves following heat acclimation. Z.J. Schlader, R.A.I. Lucas, P. glucose metabolism of offspring. K.I. Stanford, M-Y. Lee, K.M. James, M.S. Ganio and C.G. Crandall. Presbyterian Hosp. of Getchell, M.F. Hirshman and L.J. Goodyear. Joslin Diabetes Dallas, Cardiff Metro. Univ., U.K. and Univ. of Arkansas. Ctr. B334 1133.7 Dietary nitrate supplementation augments B349 1134.5 Effects of in utero heat stress on post- cutaneous reflex vasodilation in healthy humans. E.L. Levitt, natal thermoregulation. J.S. Johnson, J. Ross, J. Selsby, J.T. Keen and B.J. Wong. Kansas State Univ. R. Boddicker, M. Lucy, T. Safranski, R. Rhoads and L. B335 1133.8 Effects of dietary nitrate supplementation Baumgard. Iowa State Univ., Univ. of Missouri-Columbia and on NO-mediated vasodilation during local heating in healthy VPI and State Univ. humans. J.T. Keen, E.L. Levitt and B.J. Wong. Kansas State B350 1134.6 Exercise ameliorates high fat diet-mediated Univ. inflammation, DNA methylation and heart failure in female B336 1133.9 Microvascular function is reduced in mice. V. Chavali, J.M. Harris, S. Givvimani, N. Qipshidze, normotensive salt-sensitive individuals independent of dietary L.A. Murphy, G. Tyagi, N. Metreveli, S.C. Tyagi and P.K. sodium intake. J.J. DuPont, J.L. Greaney, E.M. Matthews, Mishra. Univ. of Louisville. S.L. Lennon-Edwards, W.B. Farquhar and D.G. Edwards. Univ. of Delaware. 1135. CENTRAL NERVOUS SYSTEM MODULATION B337 1133.10 ETA subtype receptor sensitivity to testosterone OF CARDIORESPIRATORY RESPONSES TO contributes to microvascular dysfunction in PCOS. N. HYPOXIA (POSTERS) Stachenfeld, M. Wenner and H.S. Taylor. John B. Pierce Lab., Yale Sch. of Med. and Univ. of Delaware. Poster B338 1133.11 Non-uniform age-related decrements in regional sweating and skin blood flow.C.J. Smith, L.M. Tue. 7:30 am—Boston Convention & Exhibition Center, Alexander and W.L. Kenney. Penn State. Exhibit Halls A-B B339 1133.12 Acute oral sapropterin (Kuvan®) augments Presentation time: 12:45 pm-3:00 pm NO-dependent reflex vasodilation in aged human skin. A.E. Stanhewicz, L.M. Alexander and W.L. Kenney. Penn State. B351 1135.1 Rett syndrome mutation MeCP2 T158A affects B340 1133.13 Total/HDL cholesterol ratio predicts impaired hypoxic ventilatory response in mice. J.M. Bissonnette, S.J. NO-dependent vasodilation in human skin. J.D. Dahmus, D.H. Knopp and Z. Zhou. Oregon Hlth. & Sci. Univ. and Univ. of Craighead, W.L. Kenney and L.M. Alexander. Penn State. Pennsylvania. B341 1133.14 Characterization of the cutaneous blood flow- B352 1135.2 Recruitment of serotonergic responses in local temperature response through its entire range. R.S. cardiac vagal neurons during hypoxia and hypercapnia. L.A. Bruning, L.M. Alexander and W.L. Kenney. Penn State. Weigand and D. Mendelowitz. The George Washington Univ. B342 1133.15 A novel look at KIR channels and potassium in B353 1135.3 Central modulation of arterial chemo-baroreflex human skin. M.A. Francisco, N. Fujii, C.T. Minson and V.E. control by propofol during severe arterial hypoxia in the rabbit. Brunt. Univ. of Oregon. A.W. Quail, D.B. Cottee, R. Roach and S.W. White. Univ. of B343 1133.16 A complex interplay between NO, EDHFs, and Newcastle and Hunter Med. Res. Inst., Australia. KIR channels in cutaneous active vasodilation. V.E. Brunt, N. B354 1135.4 Knockdown of tyrosine hydroxylase in the Fujii and C.T. Minson. Univ. of Oregon. nucleus of the solitary tract reduces elevated blood pressure B344 1133.17 Endothelium-dependent cutaneous vaso- during chronic intermittent hypoxia. C.S. Bathina, A. Rajulapati, dilation in young smokers: role of endothelial-derived M. Franzke, K. Yamamoto and S. Mifflin. Univ. of North Texas hyperpolarizing factors. N. Fujii, V.E. Brunt, M.A. Francisco Hlth. Sci. Ctr. and C.T. Minson. Univ. of Oregon. B355 1135.5 Short-term sustained hypoxia affects synaptic transmission in the nucleus tractus solitarius neurons of 1134. EPIGENETICS AND EXERCISE (POSTERS) juvenile rats. D. Accorsi-Mendonça, C.E.L. Almado and B.H. Machado. Sch. of Med. of Ribeirão Preto, Univ. of São Paulo. Poster B356 1135.6 Changes in ionic currents of respiratory neurons produce sympathetic overactivity in chronic intermittent Tue. 7:30 am—Boston Convention & Exhibition Center, hypoxic rats. D.J.A. Moraes, M.P. da Silva, D.B. Zoccal, W.A. Exhibit Halls A-B Varanda and B.H. Machado. Sch. of Med. of Ribeirão Preto, Presentation time: 12:45 pm-3:00 pm Univ. of São Paulo. B357 1135.7 Sympathetic nerve activity response to acute B345 1134.1 Endurance training changes the DNA intermittent hypoxia and development of sympathetic long- methylation pattern in human skeletal muscle. M.E. Lindholm, term facilitation. A.Y. Fong, A.M. Hammond, T. Xing and P.M. F. Marabita, D. Gomez-Cabrero, H. Fischer, J. Tegnér and Pilowsky. Macquarie Univ., Australia. C.J. Sundberg. Karolinska Inst., Stockholm and Huddinge. B358 1135.8 Intermittent hypoxia induces leptin signaling B346 1134.2 HDZCs are O-GlcNAc modified and OGT in the carotid body. J. Ciriello and S.A. Messenger. Univ. of O-GlcNAcylation is decreased with acute exercise. H.M. Western Ontario. Medford and S.A. Marsh. Washington State Univ. B359 1135.9 Ventilatory instability persists 1 week after B347 1134.3 Exercise during pregnancy attenuates prenatal lipopolysaccharide exposure in newborn rat pups. A.V. Mason, high-fat diet-induced hypermethylation of the Pgc-1a gene E. Kostuk, M. Shirahata and E.B. Gauda. Johns Hopkins Sch. and protects against age-induced glucose intolerance in the of Med. and Johns Hopkins Bloomberg Sch. of Publ. Hlth. offspring. R.C. Laker, T. Lillard, M. Okutsu, J. Connelly and B360 1135.10 Developmental hyperoxia attenuates hypoxic Z. Yan. Univ. of Virginia. ventilatory depression in neonatal rats. R.W. Bavis, S.H. Grandgeorge and C.B. Hill. Bates Col.
394 TUESDAY PHYSIOLOGY
B361 1135.11 Perinatal sulfur dioxide exposure alters B374 1136.9 Endogenous estrogen enhances brachial blood brainstem parasympathetic control of heart rate. A.L. Woerman conductance during dynamic handgrip in young healthy and and D. Mendelowitz. George Washington Univ. metabolic syndrome women. R. Restaino, T. Schwermann, A. B362 1135.12 Endogenous hydrogen sulfide in the rostral Blankenship and M.A. Barlow. Eastern New Mexico Univ. ventrolateral medulla mediates ventilatory response induced B375 1136.10 Chronic depressive symptoms and gender: by hypoxia. A.F. Donatti, M. Kwiatkoski, R.N. Soriano, E.C. impact on conduit vascular outcomes. S.C. Stanley, J.T. Carnio and L.G.S. Branco. Univ. of São Paulo, Ribeirão Preto. Butcher, S.J. Frisbee, A.C. d’Audiffret and J.C. Frisbee. B363 1135.13 Measuring hydrogen sulfide at the cellular and West Virginia Univ. sub-cellular level with fluorescent nanoparticles. E.R. DeLeon, B376 1136.11 A single bout of aerobic exercise prevents the M. Galvan, S.S. Bohlson and K.R. Olson. Indiana Univ. Sch. transient endothelial dysfunction induced by mental stress in of Med. South Bend and Univ. of Notre Dame. men with metabolic syndrome. A.R.K. Sales, I.A. Fernandes, B364 1135.14 HIF-1a increases glutamatergic NMDA N.G. Rocha, V.P. Garcia, L.S. Costa, B.M. Silva and A.C.L. da receptors in the PVN during chronic heart failure. N. Sharma, Nóbrega. Fluminense Fed. Univ., Brazil. C. Cunningham, X. Liu, H. Zheng and K. Patel. Univ. of B377 1136.12 Five days of reduced physical activity Nebraska Med. Ctr. selectively impairs endothelial function of the inactive limbs. L. B365 1135.15 Autonomic function assessed with heart rate Boyle, D. Credeur, N. Jenkins, J. Padilla, J. Thyfault and P. variability in Everest climbers. J.W. Marck, A. Issa, B. Taylor, Fadel. Univ. of Missouri-Columbia. D. Summerfield, A. Kasak and B. Johnson. Mayo Clin. and B378 1136.13 The effect of L-arginine supplementation TNO, The Hague. and voluntary wheel running on vascular function in rats with chronic kidney disease. C.R. Martens, J.M. Kuczmarski, S. 1136. VASCULAR RESPONSES TO EXERCISE AND Lennon-Edwards and D.G. Edwards. Univ. of Delaware. ENVIRONMENTAL STRESS B379 1136.14 Regulation of antioxidant enzyme expression in response to exercise in skeletal muscles of dyslipidemic Poster mice. A.Q. Nguyen and E. Thorin. Montreal Heart Inst. and Univ. of Montreal. Tue. 7:30 am—Boston Convention & Exhibition Center, B380 1136.15 Role of vascular dysfunction in prostate tumor Exhibit Halls A-B perfusion during exercise. D.J. McCullough, D.W. Siemann and B.J. Behnke. Univ. of Florida. Presentation time: 12:45 pm-3:00 pm B381 1136.16 The effects of continuous-flow left ventricular B366 1136.1 Plasticity in the microvasculature of conditioned assist devices on peripheral vascular function. M.A.H. Witman, weight lifters after acute high pressure stress. M.J. Durand, H.J. Groot, J.R. Gifford, J.D. Trinity, J. Stehlik, S.G. Drakos S.A. Phillips and D.D. Gutterman. Med. Col. of Wisconsin and and R.S. Richardson. Univ. of Utah and Salt Lake City VA Univ. of Illinois at Chicago. Med. Ctr. B367 1136.2 Is sympathetic restraint of skeletal muscle B382 1136.17 Investigating relationships between arterial blood flow present during exercise? Z. Barrett-O’Keefe, S.J. stiffness and collagen turnover in humans. L. Cotie, K. Currie, Ives, J.D. Trinity, M.A.H. Witman, M.J. Rossman, H.J. Groot, J. Totosy de Zepetnek, A. Josse, G. McGill, S. Phillips and D.E. Morgan, B. Gmelch, R.S. Richardson and D.W. Wray. M. MacDonald. McMaster Univ., Canada and Univ. of Toronto. Univ. of Utah and VA Med. Ctr. B383 1136.18 Alterations in the coagulation and fibrinolytic B368 1136.3 Ascorbic acid inhibits histamine-receptor systems following an ultra-marathon. B.R. Kupchak, B.M. mediated sustained post-exercise vasodilation in humans. S.A. Volk, L. Kunces, L. Phinney, M.D. Hoffman, S.D. Phinney Romero, J.M. Kono and J.R. Halliwill. Univ. of Oregon. and J.S. Volek. Univ. of Connecticut, UCLA, Univ. of California B369 1136.4 Nitric oxide-mediated vascular function in Davis Med. Ctr., VA Northern California Hlth. Care Syst. and response to limb movement: the impact of age. J.D. Trinity, H.J. Univ. of California, Davis. Groot, G. Layec, M.J. Rossman, S.J. Ives, D.E. Morgan, B.S. B384 1136.19 Coronary blood flow during cold air breathing: T Gmelch, A. Bledsoe and R.S. Richardson. VA Med. Ctr. and mechanistic insights using pharmacological blockade. M.D. Univ. of Utah. Muller, Z. Gao, J.L. Mast, U.A. Leuenberger and L.I. Sinoway. U B370 1136.5 Contributions of nitric oxide and prostaglandins Penn State Col. of Med. E to exercise hyperemia in young obese adults. R.E. Johansson, B385 1136.20 Adenosine receptor inhibition attenuates J.W. Harrell, J.K. Limberg, M.K. Crain, C.L. Rousseau, P.A. cutaneous vasoconstriction during whole-body cooling. G.P. Yanke, J.J. Sebranek, B.J. Walker, M.W. Eldridge and W.G. Kenny, R. McGinn, B. Swift and D. Gagnon. Sch. of Human Schrage. Sch. of Med. and Publ. Hlth., Univ. of Wisconsin- Kinetics, Univ. of Ottawa. Madison. B371 1136.6 The effect of short-term exercise training and 1137. CONTROL OF BREATHING: CHEMORECEPTION nitric oxide on the adaptation of femoral vascular conductance at the onset of contraction. T. Just, N.G. Jendzjowsky and Poster D.S. DeLorey. Univ. of Alberta. B372 1136.7 Contribution of nitric oxide in the contraction- Tue. 7:30 am—Boston Convention & Exhibition Center, induced rapid vasodilation in young and older adults. D.P. Exhibit Halls A-B Casey, B.G. Walker, S.M. Ranadive, J.L. Taylor and M.J. Presentation time: 12:45 pm-3:00 pm Joyner. Mayo Clin. B373 1136.8 Sex related differences in vasodilator B386 1137.1 Carbonic anhydrase activity underlies spike responsiveness to hypoxia at rest and during exercise. J.R.A. frequency adaptation in avian intrapulmonary chemoreceptors. Shepherd, M.J. Joyner and D.P. Casey. Mayo Clin. K.L. Sheridan, J-G. Lonjaret and S.C. Hempleman. Northern Arizona Univ.
395 PHYSIOLOGY TUESDAY
B387 1137.2 Two potassium-channel blockers differently B401 1137.16 ATP acts via P2Y1 receptors in the preBötzinger affect afferent signal of avian intrapulmonary chemoreceptors. complex in vivo to attenuate the secondary hypoxic respiratory J-G. Lonjaret, K.L. Sheridan and S.C. Hempleman. Northern depression. V. Rajani, J.D. Zwicker, S. Pagliardini and G.D. Arizona Univ. Funk. Univ. of Alberta.
B388 1137.3 Pulmonary neuroendocrine H146 cells as B402 1137.17 Increased respiratory rhythm and O2 and CO2 hypercapnic sensors. K. Ludlow and J. Buttigieg. Univ. of chemosensitivity in juvenile rats submitted to perinatal protein Regina, Canada. undernutrition. J.H. Costa-Silva, J.L.B. Alves, V.O. Nogueira, B389 1137.4 Changes in expression and activity of MnSOD G.B. Oliveira, G.S.F. Da Silva, A.G. Wanderley and C.V.G. and CuZnSOD in carotid body and adrenal medullary cells of Leandro. Fed. Univ. of Pernambuco, Vitoria de Santo Antão rats exposed to chronic intermittent hypoxia. E. Moya, C.R. and Recife and Univ. of São Paulo, Ribeirão Preto. Varela, P. Arias and R. Iturriaga. Pontifical Catholic Univ. of B403 1137.18 Hypoglycemia-induced hyperpnoea: a role for Chile. epinephrine and the carotid body? E.L. Thompson, C.J. Ray, B390 1137.5 Key role for the multimodal CaSRr in A. Coney and P. Kumar. Univ. of Birmingham, U.K. pulmonary neuroepithelial body microenvironment physiology. B404 1137.19 Consequences of a maternal vitamin B6 R. Lembrechts, I. Brouns, K. Schnorbusch, I. Pintelon, P.J. deficiency on hypercapnic response in rat pups.J.L. St. Kemp, J-P. Timmermans, D. Riccardi and D. Adriaensen. Laurent, K. Iceman and M.B. Harris. Univ. of Alaska Fairbanks. Univ. of Antwerp, Belgium and Sch. of Biosci., Cardiff Univ., B405 1137.20 The origin of air breathing in vertebrates: turn U.K. (on) your head and cough. M. Hoffman, B.E. Taylor and M.B. B391 1137.6 A fetal mouse lung slice model for molecular Harris. Univ. of Alaska Fairbanks. live cell imaging of the pulmonary neuroepithelial body B406 1137.21 Intermittent hypercapnia-induced
microenvironment. K. Schnorbusch, I. Brouns, R. Lembrechts, GABAergic plasticity sufficiently enhances ventilatory CO2/ I. Pintelon, J-P. Timmermans and D. Adriaensen. Univ. of pH chemosensitivity to overcome serotonergic dysfunction. Antwerp, Belgium. B.P. Mosher, B.E. Taylor and M.B. Harris. Univ. of Alaska B392 1137.7 Carotid body denervation attenuates Fairbanks. oscillations in respiratory rate and sympathetic nerve activity, B407 1137.22 Medullary raphé chemosensory amplifier and decreases apnea/hypopnea index in congestive heart interneurons are mediated by serotonin/substance P and failure. N.J. Marcus, R. Del Rio and H.D. Schultz. Univ. of GABA-synthesizing neurons in situ. K.E. Iceman and M.B. Nebraska Med.Ctr. Harris. Univ. of Alaska Fairbanks.
B393 1137.8 GAL-021 increases CO2-chemosensitivity at B408 1137.23 Ionotropic but not metabotropic glutamatergic doses that do not stimulate minute ventilation. S.M. Baby, F.J. receptors in the locus coeruleus modulate the hypercapnic Golder, A.P. Kennedy, S. Peng and D.E. McIntyre. Galleon ventilatory response in unanesthetized rats. M.B. Dias, C.L. Pharmaceuts. Inc., Horsham, PA. Taxini, C.C.I. Puga, L.H. Gargaglioni and K.C. Bícego. São B394 1137.9 Medullary raphé transcriptome comparisons Paulo State Univ., Botucatu, Jaboticabal and IBILCE, São Jose among inbred rat strains differing in ventilatory sensitivity to do Rio Preto, Brazil.
CO2. M.R. Hodges, C. Yang, G.C. Mouradian, P. Liu and M. B409 1137.24 Hypercapnic acidosis increases glutamatergic Liang. Med. Col. of Wisconsin. but decreases GABAergic input to chemosensitive neurons B395 1137.10 Isoflurane stimulates firing frequency and from the caudal nucleus tractus solitarius from neonatal rats.
masks chemosensitivity of CO2-inhibited GABAergic neurons K-Y. Li and R.W. Putnam. Wright State Univ. Boonshoft Sch. in situ. S.L. Johansen, K.E. Iceman, G.B. Richerson and of Med.
M.B. Harris. Univ. of Alaska Fairbanks and Univ. of Iowa. B410 1137.25 Accelerators and brakes in CO2 chemosensitive B396 1137.11 Chemosensitive neurons in the retrotrapezoid neurons. M.C. Quintero, J.M. Cordovez and R.W. Putnam. nucleus express SK channels with low Ca2+ affinity.X. Chen, Los Andes Univ., Colombia and Wright State Univ. J. Hawryluk, A.V. Tzingounis and D.K. Mulkey. Univ. of B411 1137.26 Brain-derived erythropoietin modulates the Connecticut. hypercapnic ventilatory response during early postnatal life. J. B397 1137.12 Effects of leptin in the retrotrapezoid nucleus Soliz. Laval Univ., Canada.
on CO2-sensitivity and respiration. M. Bassi, W.I. Furuya, J.V. B412 1137.27 Erythropoietin increases the hypoxic sensitivity Menani, D.S. Colombari, J.M. do Carmo, A. da Silva, J.E. of the neural respiratory control system in newborn mice. J. Hall, I.C. Wenker, D. Mulkey and E. Colombari. São Paulo Soliz. Laval Univ., Canada. State Univ., Araraquara, Univ. of Mississippi Med. Ctr. and Univ. B413 1137.28 Thiosulfate: a readily accessible source of of Connecticut. hydrogen sulfide in oxygen sensing. K.R. Olson, E.R. DeLeon, B398 1137.13 Role of purinergic neurotransmission in Y. Gao, K. Hurley, V. Saduskas, C. Batz and G. Stoy. Indiana
different brainstem CO2-chemoreceptor regions. I.C. Wenker, Univ. Sch. of Med.-South Bend and Univ. of Notre Dame. C.R. Sobrinho, A.C. Takakura, T.S. Moreira and D.K. Mulkey. B414 1137.29 NAD(P)H autofluorescence induction by Univ. of Connecticut and Univ. of São Paulo. compound C in rat carotid chemoreceptor cells. I. Kim, J.L. B399 1137.14 Chemosensory control by purinergic signaling Fite, D. Kim, D.F. Donnelly and J.L. Carroll. Univ. of Arkansas within the retrotrapezoid nucleus in conscious rats. B.F. Barna, for Med. Sci., Chicago Med. Sch. and Yale Univ. Sch. of Med. A.C. Takakura, D.K. Mulkey and T.S. Moreira. Univ. of São Paulo and Univ. of Connecticut. B400 1137.15 Purinergic signaling in the retrotrapezoid nucleus contributes to central and peripheral chemoreflexes by divergent mechansims. T.S. Moreira, C.R. Sobrinho, I.C. Wenker, D.K. Mulkey and A.C. Takakura. Univ. of São Paulo and Univ. of Connecticut.
396 TUESDAY PHYSIOLOGY
1138. VASCULAR PATHOBIOLOGY I 1139. VASCULAR SMOOTH MUSCLE II
Poster Poster
Tue. 7:30 am—Boston Convention & Exhibition Center, Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Exhibit Halls A-B
Presentation time: 12:45 pm-3:00 pm Presentation time: 12:45 pm-3:00 pm B415 1138.1 Polyphenols prevent obesity-induced aortic B425 1139.1 The function of cAMP responsive element vascular stiffness in C57BL/6 mice. R.M. Weisbrod, J. Fry, P. modulator in PDGF induced proliferation of vascular smooth Chauhan, R.A. Cohen and F. Seta. Boston Univ. Sch. of Med. muscle cells. M.D. Seidl, I. Hildebrandt, C. Klugstedt, F. B416 1138.2 Expression of dysfunctional connexin40 in Nunes, S. Endo, N. Kojima, W. Schmitz and F.U. Müller. Univ. vascular endothelium enhances myogenic constriction and of Münster, Tokyo Metro. Inst. of Gerontol. and Gunma Univ. reduces artery distensibility. D.J. Chaston, B.K. Baillie, T.H. Med. Sch., Japan. Grayson, R.J. Courjaret, J.M. Heisler, K.A. Lau, K. Machaca, B426 1139.2 cGMP-dependent protein kinase I (PKGI) B.J. Nicholson, A. Ashton, K.I. Matthaei and C.E. Hill. undergoes post-translational modifications in the Golgi Australian Natl. Univ., Weill Cornell Med. Col.-Qatar, Univ. of apparatus. S. Kato and J.D. Roberts, Jr. Massachusetts Gen. Texas Hlth. Sci. Ctr. at San Antonio and Univ. of Sydney. Hosp., Charlestown. B417 1138.3 Arterial stiffness in diet-induced obese mice B427 1139.3 Inhibition of vascular smooth muscle growth is reversed by weight loss. T. Shiang, L. Al Sayah, J. Fry, R. by the soluble guanylyl cyclase activator BAY 60-2770. D.N. Weisbrod, S. Bajpai, C. Reinhart-King, R. Cohen and F. Martin, S.P. Adderley, C.N. Joshi, W. Durante and D.A. Tulis. Seta. Boston Univ. and Cornell Univ. Brody Sch. of Med. at East Carolina Univ. and Univ. of Missouri- B418 1138.4 Vascular aging: association between Columbia Sch. of Med. endothelial function and arterial stiffness. M. Heldens, T. B428 1139.4 Cascade transmission in skeletal muscle Tarumi, M. Ayaz, R. Parker, C. Tinajero, C. Hill, B.Y. Tseng, arteries. H.A. Kluess. Auburn Univ. J. Liu and R. Zhang. Radboud Univ. Nijmegen Med. Ctr., B429 1139.5 Molecular interactions of serotonin and Netherlands, Texas Hlth. Presbyterian Hosp. Dallas and Univ. endothelin-1 in vascular smooth muscle cells: roles of p42/44 of Texas Southwestern Med. Ctr. mitogen activated protein kinase and Janus kinase 2 pathways. B419 1138.5 Angiotensin II increases arterial stiffness that S. Bhaskaran, J. Zaluski and A.K.L. Banes-Berceli. Oakland is prevented by polyphenol S17834. J.L. Fry, R.M. Weisbrod, Univ., MI. F. Seta and R.A. Cohen. Boston Univ. Med. Ctr. B430 1139.6 TNFa receptor 1 causes endocytosis- B420 1138.6 Toll-like receptor 4 mediates cavernosal dependent NF-kB and -independent JNK activation in vascular dysfunction in diabetic rats. K.P. Nunes, M.A. Carrilo- smooth muscle cells. H. Choi and F.S. Lamb. Vanderbilt Univ. Sepulveda, T. Szasz and R.C. Webb. Georgia Hlth. Sci. Univ. Med. Ctr. B421 1138.7 Novel anti-atherogenic effects of trivalent B431 1139.7 Hydrogen peroxide modulates the contractile chromium in vascular smooth muscle cells: therapeutic response induced by phenylephrine in renal hypertensive implication for diabetic vascular complications. R. Ganguly, S. rat aorta. B.R. Silva, L. Pernomian, M.D. Grando and L.M. Sahu and P. Raman. Northeast Ohio Med. Univ. Bendhack. Sch. of Med. and Fac. of Pharmaceut. Sci. of B422 1138.8 Reduced NO bioavailability, oxidative stress Ribeirão Preto, Univ. of São Paulo. and alteration of calcium homeostasis in vascular endothelium B432 1139.8 Reactive oxygen species and purinergic from diabetic mice. S. Banquet, M.P. Bourguignon, A. Garry, signaling contribute to the thyroid hormone-induced E. Royere, C. Crespo, I. Lapret, S. Simonet, W. Gosgnach, vasodilation. C.R. Fürstenau Basso, L.R.G. Bechara, A. C. Thollon, N. Villeneuve and J.P. Vilaine. Servier Res. Inst., Belló-Klein, P.C. Brum and M.L.M. Barreto-Chaves. Sch. of Suresnes, France. Phys. Educ. and Sport, Univ. of São Paulo and Fed. Univ. of Rio B423 1138.9 Transcriptional mechanisms that mediate Grande do Sul, Brazil. T upregulation of thrombospondin-1 expression by leptin in B433 1139.9 The G protein-coupled estrogen receptor U vascular smooth muscle cells. S. Sahu, R. Chavez, R. Ganguly 1 (GPER1/GPR30) agonist G-1 regulates vascular smooth E and P. Raman. Northeast Ohio Med. Univ. muscle cell Ca2+ handling. A. Holm, B. Olde, F. Leeb-Lundberg B424 1138.10 Angiopoietin like-2 knock-down improves the and B-O. Nilsson. Lund Univ., Sweden. lipid profile of high-fat diet-fed mice and maintains vascular endothelial function. C. Yu and E. Thorin. Montreal Heart Inst. 1140. LUNG PHYSIOLOGY: PULMONARY and Univ. of Montreal. HYPERTENSION
Poster POSTER PRESENTERS: Tue. 7:30 am—Boston Convention & Exhibition Center, UPLOAD YOUR POSTER Exhibit Halls A-B
Where: E-Poster Counter, Sun. – Tue. Hall A; Wed. Hall C Presentation time: 12:45 pm-3:00 pm Deadline: Tue., April 23, 5:00 pm; Wed., April 24, 3:00 pm B434 1140.1 Inhibition of soluble epoxide hydrolase augments hypoxic pulmonary vasoconstriction and improves Uploaded posters will be available online to all gas exchange in mice. A. Beloiartsev, C. Ventocilla, J.D. registered attendees following the meeting at Winkler, K.D. Bloch and W.M. Zapol. Massachusetts Gen. www. experimentalbiology.org Hosp. and Univ. of Pennsylvania.
397 PHYSIOLOGY TUESDAY
B435 1140.2 Mitochondrial catalase expression protects B449 1140.16 Can haptoglobin attenuate hemoglobin- against hypoxia-induced pulmonary hypertension. S.E. induced vascular damage? Y. Alonso, C. Lisk and D. Irwin. Adesina, C.M. Hart and R.L. Sutliff. Atlanta VA Med. Ctr. and Univ. of Puerto Rico at Ponce and Univ. of Colorado Denver, Emory Univ. Anschutz Med. Campus. B436 1140.3 Pressure-dependent pulmonary arterieal tone B450 1140.17 Poly ADP-ribose polymerase (PARP-1) and following chronic hypoxia requires depolarization-induced DNA damage in pulmonary arterial hypertension. J. Meloche, activation of epidermal growth factor receptor and NADPH A. Courboulin, J. Krietsch, G. Margaillan, A. Courchesne, oxidase. C.E. Norton, B.R. Walker and T.C. Resta. Univ. of Y. Coulombe, S. Provencher, G. Poirier, J-Y. Masson and S. New Mexico. Bonnet. CHUQ, Laval Univ., Canada.
B437 1140.4 Loss of endogenous H2O2-induced inhibition B451 1140.18 Inhibition of the receptor of advanced glycation of ASIC1-mediated Ca2+ influx in pulmonary artery smooth reverses pulmonary arterial hypertension. J. Meloche, A. muscle cells following chronic hypoxia. D.R. Plomaritas, L.M. Courchesne, M. Barrier, M-P. Tremblay, S. Breuils-Bonnet, Herbert, T.C. Resta, B.R. Walker and N.L. Jernigan. Univ. of E. Tremblay, S. Provencher and S. Bonnet. Laval Univ., New Mexico Hlth. Sci. Ctr. Canada. B438 1140.5 Underdeveloped bradykinin-dependent B452 1140.19 Effect of VPAC2 agonist on improving cardiac vasorelaxation in immature pulmonary arteries from long term output in pulmonary hypertension. Y. Mizuno, M. Koga, S. hypoxic sheep is not due to loss of cGMP signaling. C.L. Wee, Kashiwagi, I. Watanabe and T. Goto. Yokohama City Univ. C. Blum-Johnston, Q. Blood, R.H. Wilson, A.B. Blood, L.D. B453 1140.20 miR204/RUNX2 axis regulates HIF-1a Longo and S.M. Wilson. Loma Linda Univ. activation in pulmonary arterial hypertension. G. Margaillan, B439 1140.6 Postnatal-related changes in cAMP mediated M. Barrier, F. Potus, J. Meloche, A. Courboulin, C. Couture, pulmonary arterial relaxation and calcium signals persist P. Bonnet, S. Provencher and S. Bonnet. CRIUCPQ, Quebec. following long term hypoxia in sheep. R. Paez, M. Rubalcava, B454 1140.21 Morphological changes of the intrinsic cardiac Q. Blood, S. Hong, M. Francis, M.S. Taylor, L.D. Longo and nervous system in experimental models of right ventricular S.M. Wilson. Loma Linda Univ. and Univ. of South Alabama hypertrophy. M.J. Gómez Villalobos, R. Giles and G. Flores. Col. of Med. Autonomous Univ. of Puebla, Mexico. B440 1140.7 Bradykinin-induced pulmonary vasorelaxation is modified by long term hypoxia and postnatal maturation in 1141. LUNG PHYSIOLOGY: VASCULAR SMOOTH sheep. C. Blum-Johnston, Q. Blood, C. Wee, R. Wilson, A.B. MUSCLE BIOLOGY, VASCULAR REGULATION Blood, L.D. Longo and S. Wilson. Loma Linda Univ. AND HYPOXIA B441 1140.8 Implication of lysophosphatidic acid in hypoxic pulmonary vascular remodeling: effects on cell adhesion and Poster migration. V. Shlyonsky, R. Naeije and F. Mies. Univ. Libre of Brussels. Tue. 7:30 am—Boston Convention & Exhibition Center, B442 1140.9 TRPC1 and TRPC6 regulate chronic Exhibit Halls A-B hypoxia-induced vascular tone, vasoreactivity and pulmonary Presentation time: 12:45 pm-3:00 pm hypertension. Y. Xia, X-R. Yang, O. Paudel, Z. Fu, L. Birnbaumer and J.S.K. Sham. Johns Hopkins Univ. and Natl. B455 1141.1 Nitric oxide bioavailability in patients with cystic Inst. of Envrn. Sci., Durham. fibrosis.R.A. Harris, N. Seigler, B. Fox, C. White, L. Brantley, B443 1140.10 Adaptive immune cells contribute to chronic D. Eidson and K.T. McKie. Georgia Hlth. Sci. Univ. hypoxia-induced pulmonary hypertension. L.D. Maston, T.C. B456 1141.2 The role of the type III transforming growth Resta, J.L. Cannon, W. Giermakowska and L.V. González factor-b receptor TGFbr3 in the regulation of pulmonary Bosc. Univ. of New Mexico. vascular development. G. Niess, J. Wygowski, W. Seeger and B444 1140.11 Development and long term hypoxia: changes R.E. Morty. Max Planck Inst. for Heart and Lung Res., Bad in ryanodine receptor expression in ovine pulmonary arteries. Nauheim. K.L. Young II, R. Goyal, Q. Blood, S.M. Wilson and L.D. B457 1141.3 Effects of hypoxia on regulators of G-protein Longo. Loma Linda Univ. signaling 2 regulation of pulmonary arterial constriction. N. B445 1140.12 Pde3a-deficient mice have evidence of Jain, Y. Tu and P.W. Abel. Creighton Univ. pulmonary hypertension. B. Chen, X. Meng, Y. Jin and L.D. B458 1141.4 Quantification of reduced blood flow through Nelin. Nationwide Children’s Hosp. and The Ohio State Univ. intrapulmonary arteriovenous anastomoses in healthy humans
B446 1140.13 Pulmonary vascular reactivity with aging. K. during exercise breathing 100% O2. S. Laurie, J.E. Elliott, Pugh and G. Balanos. Sch. of Sports and Exercise Sci., Univ. J.W. Duke, R.D. Goodman, I.M. Gladstone, M.B. Fish and of Birmingham, U.K. A.T. Lovering. Johns Hopkins Med. Inst., Univ. of Oregon B447 1140.14 Transient receptor potential channels contribute and Oregon Heart & Vasc. Inst. and Sacred Heart Med. Ctr., to an enhanced endothelial cell proliferation and irreversible Springfield, OR. vascular remodeling associated with the development of B459 1141.5 Activation of calpain in pulmonary arterial pulmonary arterial hypertension. P. Sundivakkam, H. Tang, R. smooth muscle cells. L. Kovacs, R. Rafikov, A. Szabo, Z. Fernandez, A. Drennan and J.X-J. Yuan. Univ. of Illinois at Bagi, S.M. Black and Y. Su. Med. Col. of Georgia, Georgia Chicago. Regents Univ. B448 1140.15 The C-terminal tail of aquaporin 1 is required B460 1141.6 Loss of PPARg promotes NF-kB activation, for migration and proliferation of pulmonary arterial smooth Nox4 induction, and proliferation of human pulmonary artery muscle cells. N. Lai, J.M. Lade, K. Leggett, C. Undem, M. smooth muscle cells. K.M. Bijli, B-Y. Kang, T. Murphy and Crow, X. Yun and L.A. Shimoda. Johns Hopkins Univ. C.M. Hart. Atlanta VA Med. Ctr. and Emory Univ. Med. Ctr.
398 TUESDAY PHYSIOLOGY
B461 1141.7 Characterization of ryanodine receptor-gated B473 1142.10 Compartmentalization of redox processes, store-operated calcium entry in rat pulmonary artery smooth Nox4 and endoplasmic reticulum chaperones within lipid muscle cells. A.H.Y. Lin, H. Sun, Y-L. Jiang, M-J. Lin and droplets in vascular smooth muscle cells. T.B. Abrahao. InCor, J.S.K. Sham. Johns Hopkins Univ. São Paulo. B462 1141.8 Alterations in intracellular Ca2+ release via B474 1142.11 Signaling mechanism of cytochrome P450 1B1- CD38-dependent pathways in pulmonary arterial smooth dependent angiotensin II-induced activation of NADPH oxidase muscle of rat by chronic hypoxia. S. Lee, Y. Jiang, O. Paudel in vascular smooth muscle cells. C.Y. Song, B.L. Jennings, J. and J.S.K. Sham. Johns Hopkins Univ. and Johns Hopkins Lin, X.R. Fang and K.U. Malik. Univ. of Tennessee Hlth. Sci. Sch. of Publ. Hlth. Ctr., Memphis. B463 1141.9 Thioredoxin-1 is necessary for hypoxia- B475 1142.12 Quantitative analysis of tetrahydrobiopterin induced cell proliferation in human pulmonary artery smooth synthesis and oxidation in eNOS uncoupling. S. Kar and M. muscle cells. Y. Jin, T.E. Tipple, L.G. Chicoine, L.D. Nelin Kavdia. Wayne State Univ. and B. Chen. Nationwide Children’s Hosp. and The Ohio State B476 1142.13 Hydrogen peroxide induced changes in Univ. endothelial function. H. Patel, J. Chen, S. Daoud and M. Kavdia. Wayne State Univ. 1142. FREE RADICAL SIGNALING, OXIDANT STRESS AND INJURY II 1143. OXIDATIVE STRESS III
Poster Poster
Tue. 7:30 am—Boston Convention & Exhibition Center, Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Exhibit Halls A-B
Presentation time: 12:45 pm-3:00 pm Presentation time: 12:45 pm-3:00 pm B464 1142.1 Elevated peripheral blood mononuclear cell- B477 1143.1 Proteomic analysis of the lung proteome after derived superoxide production in healthy young black men. chronic ethanol exposure. A.A. Alli, D.S. Montgomery, M.S. S.H. Deo, S.W. Holwerda, D.M. Keller and P.J. Fadel. Univ. of Ghant, D.C. Eaton and M.N. Helms. Emory Univ. and Clark Missouri-Columbia and Univ. of Texas at Arlington. Atlanta Univ. B465 1142.2 Restoration of endothelial function in Ppara-/- B478 1143.2 EtOH consumption contributes to a ‘pro-injury’ mice by Tempol. N. Silswal, M.J. Wacker and J. Andresen. environment in the alcoholic lung. A.F. Eaton, L.A. Brown and Univ. of Missouri-Kansas City. M.N. Helms. Emory Univ. and Children’s Healthcare of Atlanta. B466 1142.3 Determination of Prdx6 binding sites for its B479 1143.3 Detecting cell adhesion molecules in intact interaction with SP-A. S.Y. Krishnaiah, C. Dodia, S.I. Feinstein lung using quantum dot conjugates targeted to endothelial and A.B. Fisher. Univ. of Pennsylvania Sch. of Med. cells. R.L. Orndorff, N.K. Hong, B.J. Zern, K. Yu, K. Debolt, B467 1142.4 Direct and indirect effects of particulate V.R. Muzykantov, S. Huang, A.B. Fisher and S. Chatterjee. exposure on the heart. M.W. Gorr, D.J. Youtz, E. Cormet- Univ. of Pennsylvania. Boyaka and L.E. Wold. Nationwide Children’s Hosp. and The B480 1143.4 Resolvins play a role in the resolution of Ohio State Univ. acute lung injury. R.R. Cox, Jr., O. Phillips, J. Fukumoto, B468 1142.5 Effect of prenatal antioxidant sulforaphane on I. Fukumoto, P. Tamarapu Parthasarathy, V. Lagishetty, fetal transcriptomics in mice. H-Y. Cho, L. Miller-DeGraff, L. T. Luong, N. Remsen, R. Lockey and N. Kolliputi. Univ. of Perrow, M. Yamamoto and S.R. Kleeberger. NIEHS, NIH, South Florida Morsani Col. of Med. Research Triangle Park and Tohoku Univ. Grad. Sch. of Med., B481 1143.5 ASC plays a role in alveolar epithelial integrity. J. Japan. Fukumoto, I. Fukumoto, O. Phillips, R. Cox, Jr., P. Tamarapu Parthasarathy, V. Lgishetty, R. Lockey and N. Kolliputi. Univ. B469 1142.6 Systemic oxidative stress in older adults: do T peripheral blood mononuclear cells contribute? J.C. Schanzle, of South Florida. S.H. Deo and P.J. Fadel. Univ. of Missouri-Columbia. B482 1143.6 Caveolae regulate nitroxidative signaling via U B470 1142.7 PPARa modulates acrolein-induced localized nitration of Src-family kinase in endothelial cells. H. E inflammatory signaling ingp91phox knock-out mice. K. Marek, Singh and V. Rizzo. Temple Univ. Sch. of Med. N. Chug, Z. Yousefipour and M. Newaz. Chicago State Univ. B483 1143.7 Resveratrol blunts the positive effects of and Texas Southern Univ. exercise training in aged men; a double-blind, randomized, B471 1142.8 Caveolin-1 regulates neuronal regeneration placebo-controlled training study. L. Gliemann, M. Nyberg, in peripheral nerve crush injury via regulation of Schwann cell R.S. Biensø, N. Iversen, J. Olesen, S.P. Mortensen, J.F. function. S.D. Garcia, J. Dolkas, I. Shubayev, S.E. Kellerhals, Schmidt, H. Pilegaard and Y. Hellsten. Univ. of Copenhagen J.M. Schilling, V.I. Shubayev, H.H. Patel and Y. Kim. UCSD and Rigshospitalet. and VA San Diego Healthcare Syst. B484 1143.8 Nitric oxide deficit elicits oxidative stress and B472 1142.9 Neuroprotective properties of antioxidants augments T-type calcium channel contribution to vascular tone. in stroke correlate with their effects on ischemic release of C.E. Hill, I.Y. Kuo, A. Ellis, D.J. Chaston, H-S. Shin, P.B. glutamate. P. Dohare, A. Vipani, M.C. Hyzinski-Garcia, N.H. Hansen and L. Howitt. Australian Natl. Univ., Korea Inst. of Bowens, P.J. Feustel, R.W. Keller, Jr., D. Jourd’heuil and Sci. and Technol. and Univ. of Southern Denmark. A.A. Mongin. Albany Med. Col.
399 PHYSIOLOGY TUESDAY
B485 1143.9 N-acetylcysteine administration modulates B497 1144.5 Lysophosphatidic acid induces reactive oxygen NADPH oxidase in skeletal muscle of rats with heart failure. species generation through PLC/PKC/Nox pathway in PC-3 P.F. Martinez, D.C. Fernandes, C. Bonomo, M.D.M. Cezar, prostate cancer cells. C-C. Lin, C-E. Lin, Y-C. Lin and H. Lee. S.A. Oliveira, Jr., L.A.M. Zornoff, K. Okoshi, F.R. Laurindo Natl. Taiwan Univ. and M.P. Okoshi. UNESP, Botucatu, InCor, São Paulo and B498 1144.6 Oxidative stress and ER stress induce UFMS, Campo Grande, Brazil. Zidovudine (AZT)-mediated hepatic lipid accumulation. A. B486 1143.10 Correlation between cardiovascular autonomic Banerjee, M.A. Abdelmegeed, S. Jang and B.J. Song. control dysfunction and oxidative stress in an experimental NIAAA, NIH, Rockville. model of hypertensive and menopause submitted to fructose B499 1144.7 Inspiratory muscle exercise reduces overload. F.F. Conti, J.O. Brito, R.K. Palma, N. Bernardes, I.C. lipoperoxidation in obese and healthy subjects: a pilot study. Sanches, M.C. Irigoyen and K. De Angelis. Nove de Julho C.C. Callegaro, L. Maldaner, L. Donato, A. Spring, F. Porto, Univ., Brazil and Univ. of São Paulo - Heart Inst. L. Chaves and R. Cattaneo. Univ. of Cruz Alta, Brazil. B487 1143.11 Dependence of cytotoxicity of menadione and B500 1144.8 Ketone supplementation reduces superoxide cytoprotection by antioxidants in human endothelial cells on production in cultured primary human dermal fibroblasts: oxygen levels: atmospheric oxygen versus physiological levels. comparison of young versus aged cells. S.L. Kesl, A.N. Moor, A. Rastogi, S. Stavchansky and P. Bowman. U.S. Army Inst. M.Y. Jung, A.M. Poff, L. Gould and D.P. D’Agostino. Morsani of Surg. Res., Fort Sam Houston, The Geneva Fndn., Tacoma, Col. of Med., Univ. of South Florida. WA and Univ. of Texas at Austin. B488 1143.12 Role of TRPC6 in high glucose-induced 1145. ION TRANSPORT IN CELL DIFFERENTIATION, podocyte apoptosis. B-C. Liu, X. Song, L-L. Yang, D. Eaton MIGRATION, POLARIZATION AND ADHESION and H-P. Ma. Emory Univ. Sch. of Med. (POSTERS) B489 1143.13 Superoxide and hydrogen peroxide stimulate renin release from juxtaglomerular cells. M. Mendez. Henry Poster Ford Hosp.. B490 1143.14 The effect of allopurinol administration on Tue. 7:30 am—Boston Convention & Exhibition Center, xanthine oxidoreductase and mitochondrial respiration in Exhibit Halls A-B broiler chickens. T.L. Settle, E. Falkenstein, K. Blemings and Presentation time: 12:45 pm-3:00 pm H. Klandorf. West Virginia Univ. B491 1143.15 Hydrogen peroxide is not increased in B501 1145.1 Regulation of cell motility by Na+/H+ exchanger angiotensin II-stimulated neurons overexpressing superoxide NHE1: implications for cancer development. S.F. Pedersen. dismutase. A.J. Case, R.F. Cruz and M.C. Zimmerman. Univ. Univ. of Copenhagen. of Nebraska Med. Ctr. and Univ. of Nebraska-Lincoln. B502 1145.2 ERM proteins colocalize with the Na+/H+ B492 1143.16 Proteomic analysis of the cAMP/protein kinase exchanger NHE1 in MCF-7 breast cancer cell invadopodia and A (PKA) signaling pathway identifies PKA as a regulator affect invadopodia number. G.A.B. Roest and S.F. Pedersen. of cellular response to oxidative stress. T. McCann, A.S. Univ. of Copenhagen. Wilderman, Y. Guo, S.S. Taylor and P.A. Insel. UCSD and B503 1145.3 Stable expression of the sodium iodide HHMI. symporter in metastatic cancer cells: a novel imaging tool. K.B. Gagnon, D. Chapman, D.M.L. Cooper, S. Caine, V. Verge and 1144. OXIDATIVE STRESS BIOLOGY H. Nichol. Univ. of Saskatchewan. B504 1145.4 b-Adrenergic receptor agonists known to Poster stimulate b-arrestin-dependent signaling inhibit CFTR activity, cell migration and airway epithelial restitution. E.R. Peitzman Tue. 7:30 am—Boston Convention & Exhibition Center, and S.M. O’Grady. Univ. of Minnesota, St. Paul. Exhibit Halls A-B B505 1145.5 Chloride channel inhibition reduces tail Presentation time: 12:45 pm-3:00 pm regeneration in the developing vertebrate Ambystoma mexicanum. B.M. Franklin, R. Voss and J. Osborn. Univ. of B493 1144.1 Differential effects of low pH on Ca2+-induced Kentucky. ROS emission from mitochondrial complexes I and III. D.P. B506 1145.6 Adenosine inhibits human T lymphocyte Lindsay, A.K.S. Camara, D.F. Stowe and M. Aldakkak. Med. migration via inhibition of KCa3.1 channels. A.A. Chimote, V. Col. of Wisconsin. Kucher, N. Boiko, P. Hajdu, Z. Kuras, Y-H. Yun, O. Szilagyi B494 1144.2 Attenuating complex I activity decreases p66shc and L. Conforti. Univ. of Cincinnati and North Carolina A&T phosphorylation and translocation to mitochondria during State Univ. cardiac ischemia reperfusion injury. M. Yang, D.F. Stowe, J.S. B507 1145.7 Cortactin and the actin cytoskeleton control Heisner and A.K.S. Camara. Med. Col. of Wisconsin and VA the lateral membrane mobility of Kv1.3 channels. G.V. Martin, Med. Ctr. P. Hajdu, A.A. Chimote, K. Takimoto, O. Szilagyi and L. B495 1144.3 HVCN1 contributes to superoxide production Conforti. Univ. of Cincinnati, Nagaoka Univ. of Technol., Japan independent of intracellular pH regulation. P.M. O’Connor, J. and Univ. of Debrecen, Hungary. Sun and B.A. Mazer. Georgia Hlth. Sci. Univ. B508 1145.8 The role of the Arp2/3 complex in the B496 1144.4 Loud sound-induced hearing loss is prevented cytoskeleton organization and actin-mediated sodium by methylene blue. T.M. Wilson, I. Omelcheko, S. Foster and reabsorption in kidney epithelial cells. D.V. Ilatovskaya, V. A.L. Nuttall. Oregon Hlth. & Sci. Univ. Chubinskiy-Nadezhdin, L.S. Shuyskiy, T.S. Pavlov, O. Palygin, Y.A. Negulyaev and A. Staruschenko. Med. Col. of Wisconsin and Inst. of Cytol., RAS, St. Petersburg.
400 TUESDAY PHYSIOLOGY
1146. STEM CELLS AND CELL GROWTH, 1147. CELL-BASED THERAPY FOR THE HEART DEVELOPMENT AND DIFFERENTIATION AND KIDNEY: FROM BENCH TO BEDSIDE (POSTERS) Poster Poster Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Presentation time: 12:45 pm-3:00 pm Presentation time: 12:45 pm-3:00 pm B509 1146.1 Lysophosphatidic acid inhibits megakaryocyte differentiation in CD34+ hematopoietic stem cells. K-H. Lin, B520 1147.1 Beneficial effects of angiotensin (1-7) on C-L. Yao and H. Lee. Natl. Taiwan Univ. and Yuan Ze Univ., dysfunctional CD34+ endothelial progenitor cells from patients Taiwan. with heart failure. S. Hazra, C.T. Cole-Jeffrey, C.J. Pepine, B510 1146.2 The role of lysophosphatidic acid in M.J. Katovich, M.B. Grant and M.K. Raizada. Univ. of Florida. erythropoiesis in K562 human erythroleukemia cell line. Y-H. B521 1147.2 Mesenchymal stem cells attenuate renal Ho, K-H. Lin and H. Lee. Natl. Taiwan Univ. inflammation, microvascular rarefaction and fibrosis in the B511 1146.3 Osteoblast differentiation of adipose tissue- renovascular hypertension rat model. M.A. Boim, E.B. derived mesenchymal stem cells (MSCs) is enhanced by bone Oliveira-Sales, E. Maquigussa, P. Semedo, L.G. Pereira, marrow MSC-conditioned medium. M.M. Beloti, R.F. Abuna, N.O. Camara, C.T. Bergamaschi and R.R. Campos. Fed. F.S. de Oliveira, R.B. Kato and A.L. Rosa. Sch. of Dent. of Univ. of São Paulo. Ribeirão Preto - Univ. of São Paulo. B522 1147.3 Impact of augmenting intracellular ATP on the B512 1146.4 Role of MMP-2 activation in oncostatin-M inducible release of ATP from banked erythrocytes. B.S. Kirby, induced cardiomyocyte dedifferentiation. F. Fan, M.A.M, Ali, H. Zhu, D.A. Riccio and T.J. McMahon. Duke Univ. Med. Ctr. B.G. Hughes and R. Schulz. Univ. of Alberta. and VA Med. Ctr. B513 1146.5 Characterization of cardiac progenitor cells B523 1147.4 Autonomic dysregulation and its prevention by from adult murine skeletal muscle. C.A. Pacak, I. Alpatov, S. voluntary exercise in a mouse model of chronic widespread Fullen, S.F. Emmer and D.B. Cowan. Boston Children’s Hosp. pain (fibromyalgia).R. Sabharwal, L.A. Rasmussen, K.A. and Harvard Med. Sch. Sluka and M.W. Chapleau. Univ of Iowa and VA Med. Ctr. B514 1146.6 Chronic binge alcohol-induced skeletal muscle B524 1147.5 Renal regeneration in diabetic nephropathy. wasting: implications for satellite cell function. L.E. Decker, K.J. Kelly and J. Dominguez. Indiana Univ. Med. Sch. N.J. LeCapitaine, G.J. Bagby, S. Nelson and P.E. Molina. B525 1147.6 Dystrophin insufficiency causes a Becker Mandeville H.S., Mandeville, LA and LSU Hlth. Sci. Ctr., New muscular dystrophy-like phenotype in swine. K. Hollinger, Orleans. C-X. Yang, J.W. Ross, G.A. Rohrer, D. Nonneman and J.T. B515 1146.7 Polyamines enhance satellite cell activation Selsby. Iowa State Univ. and USDA, Clay Center, NE. and expression of myogenic regulatory factors. K.J. Thornton, B526 1147.7 Differences in the association between stress, K.C. Chapalamadugu, M.E. Doumit and G.K. Murdoch. Univ. depression and cardiovascular disease risk factors in children of Idaho and Univ. of South Florida. and adults. S.C. Stanley, A.C. D’Audiffret, N. Pagano, S.J. B516 1146.8 Chronic a 1AAR stimulation may increase adult Frisbee and J.C. Frisbee. West Virginia Univ. neurogenesis and parvalbumin interneurons. A. Nielsen, K. Collette, D. Perez and V. Doze. Univ. of North Dakota and 1148. REGULATION OF EPITHLIAL WATER AND Cleveland Clin. Fndn. ION CHANNELS, TRANSCELLULAR AND B517 1146.9 Critical role of Sox9 in the differentiation of PARACELLULAR PERMEABILITY AND mesenchymal stem cells to endothelial cells. D.K. Agrawal, I. Attairu, K.P. Djossou and D. Pankajakshan. Creighton Univ. EPITHELIAL POLARITY Sch. of Med. T B518 1146.10 Genotyped adipocytes to monitor adiponectin Poster U expression in response to environmental stressors. C. Zhang, Tue. 7:30 am—Boston Convention & Exhibition Center, E J.B. Alley, S.A. Samy, D. Bohman, F. Bovenzi, L. Fitzgerald, Exhibit Halls A-B J-M. Prot, M.L. Shuler and M. Ariza-Nieto. Cornell Univ. and Guthrie Clin., Sayre, PA. Presentation time: 12:45 pm-3:00 pm B519 1146.11 Osteogenic differentiation of human B527 1148.1 Role of the epithelial Na+ channels in mesenchymal stem cells induced by nanostructures. S.Y. development of ARPKD. T.S. Pavlov, V. Levchenko, D.V. Choi, P.D. Ryu, S-W. Joo and S.Y. Lee. Seoul Natl. Univ. and Ilatovskaya, O. Palygin and A. Staruschenko. Med. Col. of Soongsil Univ., South Korea. Wisconsin. B528 1148.2 ENaC gating is coupled to the distance between the a- and bENaC subunits at the base of the thumb and wrist domains. D.M. Collier and P.M. Snyder. Univ. of Iowa Carver Col. of Med. B529 1148.3 Mice lacking protein kinase Ca show enhanced membrane localization and activity of the epithelial sodium channel in the renal cortical collecting duct. H-F. Bao, Q. Yue, T.L. Thai, J.D. Klein, J.M. Sands and D.C. Eaton. Emory Univ.
401 PHYSIOLOGY TUESDAY
B530 1148.4 Deficiency of urokinase plasminogen activator B546 1148.20 Prostaglandin receptor EP2- and EP4- suppresses epithelial sodium channels in tracheal epithelial mediated aquaporin-2 membrane accumulation does not cells. H-L. Ji, Z. Chen, X. Liang, R. Zhao and M. Zhao. Univ. of depend on cAMP. E.T.B. Olesen and R.A. Fenton. Aarhus Texas Hlth. Sci. Ctr. at Tyler. Univ., Denmark. B531 1148.5 Rab22 is involved in regulation of the epithelial B547 1148.21 Intestinal epithelial endocytosis of commensal sodium channel. X. Liu, C. Bertuccio, D. Devor and M. bacteria is dependent on IFNg-induced terminal web myosin Butterworth. Univ. of Pittsburgh. phosphorylation and brush border fanning. L-L. Wu, W-T. Kuo, B532 1148.6 Acetylation modulates ENaC degradation. P.L. W-H. Peng, K-S. Lu, Y-H. Ni and L.C-H. Yu. Natl. Taiwan Univ. Butler and P.M. Snyder. Univ. of Iowa. Col. of Med. and Natl. Taiwan Univ. Hosp. B533 1148.7 Sex differences in the effects of b-estradiol on B548 1148.22 Reduced transepithelial glucose movement ENaC current in cell culture. J.D. Mitzelfelt, M.M. Greenlee in metformin-treated airways correlates with inhibition of and D.C. Eaton. Emory Univ. hyperglycemia-induced bacterial growth. J.P. Garnett, E.H. B534 1148.8 Heterogeneous nuclear ribonucleoprotein A2/ Baker, J.S. Tregoning and D.L. Baines. St George’s, Univ. of B1 is a novel aldosterone target gene in the rat distal colon London and Imperial Col. London. epithelium. D. Alvarez de la Rosa, I. Hernandez-Diaz, S. B549 1148.23 Zebrafish as a model to analyze macromolecule Morales, G. Hernandez, E. Salido, C.M. Canessa and T. absorption in intestinal enterocytes. J.L. Cocchiaro, A. Navis, Giraldez. Univ. of La Laguna, Univ. Hosp. NS Candelaria, M. Bagnat and J.F. Rawls. Univ. of North Carolina at Chapel Santa Cruz de Tenerife, Univ. Hosp. of Canarias, La Laguna, Hill and Duke Univ. Spain and Yale Univ. Sch. of Med. B550 1148.24 Paracellular urate transport in the placenta.
B535 1148.9 Evaluation of the H2S gasotransmitter system H. Sakurai, T. Kimura, A. Tsukada, S. Ohtsuki, I. Uehara, as a regulator of transepithelial sodium absorption in native S. Tanigaki, M. Iwashita and K. Ichida. Kyorin Univ. Sch. of lung epithelia (Xenopus laevis). M. Althaus, A. Erb, A. Agné, Med., Tokyo Metro. Ohtsuka Hosp., Kumamoto Univ. Fac Life K.R. Olson, P. Glombik, W.G. Clauss and M. Fronius. Justus Sci, Kyorin Univ. Sch. of Med. and Tokyo Univ. Pharm. & Life Liebig Univ., Germany and Indiana Univ. Sch. of Med.-South Sci., Japan. Bend. B536 1148.10 Biomechanical forces differentially regulate 1149. COMPARATIVE AND EVOLUTIONARY signaling in the cortical collecting duct. R. Carrisoza, C.K. PHYSIOLOGY: CARDIOVASCULAR, Else, D. Flores, H.G. Lee, F.Y. Lee, R. Rohatgi and L.M. RESPIRATORY, LOCOMOTION AND Satlin. Mount Sinai Sch. of Med., Columbia Univ. Col. of P&S METABOLISM and James J. Peters VA Med. Ctr. B537 1148.11 Mechanosensitive activation of ATP-sensitive Poster K+ channels in native pulmonary epithelium depends on pannexin and connexin hemichannel mediated ATP release. K. Tue. 7:30 am—Boston Convention & Exhibition Center, Richter, K.P. Kiefer, M. Lintges, L. Geissert, W. Clauss and Exhibit Halls A-B M. Fronius. Justus Liebig Univ., Giessen. B538 1148.12 Activation of electrogenic K secretion requires Presentation time: 12:45 pm-3:00 pm BK channels in guinea pig distal colon. D.R. Halm, J. Zhang B551 1149.1 Transmural variation in the length-force and S.T. Halm. Wright State Univ. relationships and in vivo operating length ranges of the mantle B539 1148.13 Ion transport across the murine retinal pigment muscles of squid. H. Perilstein, J.T. Thompson, R.M. Shelton epithelium. S.S. Arnason, S.B. Skarphedinsdottir and T. and W.M. Kier. Franklin & Marshall Col., PA and Univ. of North Eysteinsson. Univ. of Iceland. Carolina at Chapel Hill. B540 1148.14 Inhibition of NFkB activity in renal collecting B552 1149.2 Investigating jumping of various Caelifera duct cells abolishes transepithelial voltage difference. P. grasshopper species over an altitudinal gradient in New York. Svenningsen and B.L. Jensen. Univ. of Southern Denmark. A.R. Stamatis, O.C. Townsend and S.D. Kirkton. Union Col., B541 1148.15 Evidence for the existence of calcium signaling N Y. domains in a renal cortical collecting duct cell line. T.L. Thai, B553 1149.3 Scaling of midgut perimeter and amino acid H-F. Bao, B. Liu, H. Ma and D.C. Eaton. Emory Univ. transporter expression in Manduca sexta larvae. C.M. Gillen, B542 1148.16 Deletion of claudin-7 in renal collecting duct H. Itagaki, A.J. Yeoh, A.V. Vela-Mendoza, K.P. Connell, A.G. cells impairs paracellular chloride permeability. J. Fan, R. Sanderlin and A.J. Kerkhoff. Kenyon Col., OH. Tatum, J. Hoggard, B.G. Jeansonne and Y-H. Chen. Brody B554 1149.4 Micro-CT measured tracheal changes in the Sch. of Med., East Carolina Univ. metathoracic femur of developing American locusts. K.L. Marti, B543 1148.17 GPCR activation of CFTR through two A.J. Rapoff and S.D. Kirkton. Union Col., NY. independent phosphorylation pathways. A. Billet and J.W. B555 1149.5 Using corrosion casts to understand oxygen Hanrahan. McGill Univ. delivery in the grasshopper leg. N.M. Ferrara and S.D. Kirkton. B544 1148.18 AQP2 poly-phosphorylation and water Union Col., NY. permeability in inner medullary collecting duct. C.A. Miranda, B556 1149.6 Temperature-dependent variation in respiratory J.W. Lee, C.L. Chou and M.A. Knepper. NHLBI, NIH. patterns and spiracular control in Rhodnius prolixus. E. B545 1148.19 Mechanisms of interferon gamma-induced Heinrich and T. Bradley. Univ. of California, Irvine. suppression of aquaporin 1 in murine intestinal epithelium. B557 1149.7 Respiration and ventilation responses to acute M. Dicay, N. Ronaghan, M. Peplowski, C. Carati and W.K. hypoxic stress in the Guyana orange spotted cockroach. C.S. MacNaughton. Univ. of Calgary, Canada and Flinders Univ., Mallery, Jr. and E.M. Dzialowski. Univ. of North Texas. Australia.
402 TUESDAY PHYSIOLOGY
B558 1149.8 Pharmacogenetic approaches in altering 1150. AGING AND MUSCLE FUNCTION heart rate in Drosophila larvae. R.L. Cooper, Z.R. Majeed, J. Titlow, A. Stacy, K. King, J.M. Rufer and C.D. Nichols. Univ Poster of Kentucky, Univ of Salahaddin Col. of Sci., Iraq and LSU Hlth. Sci. Ctr., New Orleans. Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B B559 1149.9 Enhanced cardiac KATP channel activity after acclimation to hypoxia in goldfish (Carassius auratus L.). J.P. Presentation time: 12:45 pm-3:00 pm DeWitt, T.T. Ngo, S. Chan and J.S. Cameron. Wellesley Col. B560 1149.10 Paradoxical anaerobism in desert pupfish. M. B573 1150.1 Motor unit number estimates in world-class Heuton, S. Steinberg, S. Hillyard and F. van Breukelen. Univ. masters athletes: is 80 the new 60? M.D. Allen, G.A. Power, of Nevada Las Vegas. M.E. Filion, T.J. Doherty, C.L. Rice, T. Taivassalo and R.T. B561 1149.11 Heart rate, blood pressure and baroreflex gain Hepple. Sch. of Kinesiol., Univ. of Western Ontario, Montreal in three species of anurans from different environments. K.A. Neurol. Inst. and McGill Univ. Hlth. Ctr. McNew and M.S. Hedrick. Univ. of North Texas. B574 1150.2 Comparative effects of high velocity and low B562 1149.12 Effects of developmental hypoxia on alligator velocity power training on muscle performance, muscle mass cardiac myocytes. H.A. Shiels, H. Moore, C. Hill, R. Elsey, and functional ability in mobility-limited elders: a randomized D. Warren and D. Crossley. Univ. of Manchester Univ. of trial. K.F. Reid, K.I. Martin, G. Doros, D.J. Clark, C. Patten, North Texas, Saint Louis Univ. and Rockefeller Refuge, Grand E.M. Phillips, C. Hau, W.R. Frontera and R.A. Fielding. Chenier, LA. USDA at Tufts Univ., Boston Univ. Sch. of Publ. Hlth., Malcom B563 1149.13 Environmentally-induced phenotypic plasticity Randall VA Med. Ctr., Gainesville, FL and Vanderbilt Univ. in embryonic reptiles. D.A. Crossley, R. Elsey, C. Marks and B575 1150.3 Effect of hypovitaminosis D on muscle function J. Eme. Univ. of North Texas and Rockefeller Wildlife Refuge, and physical performance in Saudi women cross sectional. Grand Chenier, LA. K.S. Hussein. Surrey Univ., U.K. and Physiol., Jeddah, Saudi B564 1149.14 Lung volume and pulmonary compliance in the Arabia. alligator (Alligator mississippiensis). M.S. Hedrick, Z.F. Kohl, B576 1150.4 Stereological analysis of Akt in muscles of M. Khan, J. Eme, E.M. Dzialowski and D.A. Crossley. Univ. of young and old rats following a single bout of stretch-shortening North Texas. contractions. E.P. Rader, J. Ensey and B.A. Baker. NIOSH, B565 1149.15 The effects of hypoxic development on cardiac WV. function in fetal chickens. S.S. Jonker and D.A. Crossley II. B577 1150.5 The combined effects of anastrozole and Oregon Hlth. & Sci. Univ. and Univ. of North Texas. testosterone or trenbolone on prostate and levator ani- B566 1149.16 Heart rate and metabolic rate of bar-headed bulbocavernosus mass. D.T. Beck, J.F. Yarrow, S.C. McCoy, geese flying in hypoxia. J.U. Meir, W. Jardine, J. York, B. Chua L.A. Beggs, F. Ye, A. Balaez, S.M. Combs, J.R. Miller, C.F. and W.K. Milsom. Harvard Med. Sch. and Univ. of British Conover and S.E. Borst. Malcom Randall VA Med. Ctr. and Columbia. Univ. of Florida. B567 1149.17 Development of endothermy in the Pekin duck B578 1150.6 Old age of male C57/BL6 mice coincides with (Anas pekin). S. Ream, A. Duquaine, S.K. Goy Sirsat, T.S. development of sarcopenia and anabolic resistance. M. van Sirsat and E.M. Dzialowski. Univ. of North Texas. Dijk, J. Nagel, F.J. Dijk, S. Walrand, K. van Norren and Y. B568 1149.18 The small heart of the ornate tinamou is Luiking. Danone Res., Wageningen, Netherlands and Univ. compatible with endothermy and flight but compromises d’Auvergne, France. aerobic metabolism and thermoregulation during recovery B579 1150.7 Neural and bioenergetic mechanisms of human from exhaustive activity. J. Altimiras, L.M. Giraldo Deck and skeletal muscle fatigue resistance in old age. J. Kent-Braun, A. Á. Garitano-Zavala. Linköpings Univ., Sweden and Univ. Tonson, J. Deblois, J. Fay, T. O’Brien, S. Foulis, G. Kamen, Mayor de San Andrés, Bolivia. D. Befroy, K. Holste and A. Christie. Univ. of Massachusetts Amherst, Yale Univ. and Univ. of Oregon. B569 1149.19 Influence of regular endurance training on T postexercise hemodynamic regulation to orthostatic challenge. B580 1150.8 Sarcopenia and hypertrophy in aged skeletal J. Sugawara, H. Komine, T. Miyazawa, T. Imai and S. Ogoh. muscle is independent of lifelong muscle stem cell depletion. J.D. U Natl. Inst. of Adv. Ind. Sci. and Technol., Tsukuba, Univ. of Lee, J. Mula, C.S. Fry, T.J. Kirby, J.R. Jackson, J.A. Beggs, E Tsukuba and Toyo Univ., Japan. M.S. Campbell, T.E. Kmiec, E.E. Dupont-Versteegden, J.J. B570 1149.20 Pulmonary functions in different phases of McCarthy and C.A. Peterson. Univ. of Kentucky. menstrual cycle. E. Saperova and D. Dimitriev. Chuvash State B581 1150.9 Age-associated attenuation of autophagy Pedagogical Univ., Russia. underlies ryanodine receptor hyperactivity. L.L. Cooper, Y.C. B571 1149.21 The new mode to neurohumoral regulation Lu, J. Centracchio, R. Terentyeva, D. Terentyev and G. in respiratory and circulatory systems. X-G. Sun. Natl. Ctr. of Koren. Brown Univ. and Rhode Island Hosp., Alpert Med. Sch. Cardiovasc. Dis., Beijing. B582 1150.10 The influence of satellite cell-depletion on B572 1149.22 Effects of acetylcholine and cholinergic glycosaminoglycan accumulation in aged skeletal muscle. Z.J. antagonists on the activity of nucleus of the solitary tract Hardyniec, J.D. Lee and C.A. Peterson. Alma Col., MI and neurons. W.I. Furuya, E. Colombari, A.V. Ferguson and D.S. Univ. of Kentucky. Colombari. São Paulo State Univ., Araraquara and Queen’s Univ., Canada.
403 PHYSIOLOGY TUESDAY
1151. MICRORNA AND STEM CELLS IN MUSCLE B595 1152.11 Improvements in aerobic fitness but not PATHOPHYSIOLOGY mitochondrial content are intensity dependent in overweight men. J.C. Boyd, C.A. Simpson, M.E. Jung and B.J. Gurd. Poster Queen’s Univ., Canada and Univ. of British Columbia at Okanogan. Tue. 7:30 am—Boston Convention & Exhibition Center, B596 1152.12 The differential accumulation of doxorubicin in Exhibit Halls A-B the soleus and gastrocnemius muscle of the rat. S.A. Fabris, P. Presentation time: 12:45 pm-3:00 pm Chenard, L. Anderson and D. MacLean. Laurentian Univ. and Northern Ontario Sch. of Med. B583 1151.1 Mitochondrial division inhibitor ameliorates B597 1152.13 Cellular mechanims for the protective effects of post-myocardial infarction via stimulating stem cell by elevating prior exercise on statin-associated muscle force loss in mice. level of miR-499 in diabetes. N. Qipshidze, P.K. Mishra and M. Godar, C. Chamney and K. Huey. Drake Univ. S.C. Tyagi. Univ. of Louisville. B598 1152.14 The role of increased sarcolipin expression in B584 1151.2 miR-133a ameliorates cardiac stem cells neonatal development and in muscle disease. M. Pant, N.C. survival and differentiation in Insulin2 mutant diabetic mice. Bal, D.A. Delfin, J.A. Rafael-Fortney and M. Periasamy. The V. Chavali, N.L. Diaz, S.C. Tyagi and P.K. Mishra. Univ. of Ohio State Univ. Louisville. B599 1152.15 Specific and progressive diaphragmatic myopathy during the development of heart failure. A.J. Foster, 1152. SKELETAL MUSCLE PHYSIOLOGY A. Arkell, M. Platt, J.A. Simpson and C.L. Murrant. Univ. of Guelph, Canada. Poster B600 1152.16 The interactive effects of K+ and Cl- on force generation in skeletal muscles: impact at the onset of exercise. Tue. 7:30 am—Boston Convention & Exhibition Center, A.M. Higgins and J-M. Renaud. Univ. of Ottawa. Exhibit Halls A-B B601 1152.17 Characterization of myogenesis in C2C12 Presentation time: 12:45 pm-3:00 pm myoblasts using flow cytometry. Z. Yang, C. Mo, J. Isaacson, S. Romero-Suarez, J. Vallejo, A. Alsousi, L. Wetmore and M. B585 1152.1 Effects of estrogen on statin-induced toxicity Brotto. William Jewell Col., MO and Sch. of Pharm. and Sch. in proliferating and differentiating myoblasts. C.C. Mertz, M. of Nursing, Univ. of Missouri-Kansas City. Bielman and K.L. Ball. Alma Col., MI. B602 1152.18 Prostaglandin E2 signaling plays an important B586 1152.2 Interleukin 6 alters myogenic regulatory role in the regulation of the cell cycle progression in C2C12 factors expression in cultured mammalian satellite cells. J.A. myoblasts. C. Mo, J. Vallejo, J. Isaacson, Z. Yang, L. Wetmore, Macumber, K.J. Thornton, M.E. Doumit and G.K. Murdoch. T. Allen, O. Igwe and M. Brotto. Univ. of Missouri-Kansas City Univ. of Idaho. and William Jewell Col., MO. B587 1152.3 MC3R activation does not attenuate pro- B603 1152.19 Dissociation of recovery of muscle activation inflammatory macrophage-induced reductions in myoblast and force following a sustained maximal isometric contraction. proliferation. D.S. Kump, S. Brooks and R.A. Kump. Winston- K.E. Houle, B.J. Kantner and W.F. Brechue. U.S. Military Salem State Univ. and Hanes Magnet Sch., Winston-Salem. Acad., West Point and Philadelphia Col. of Osteo. Med. B588 1152.4 Satellite cells regulate the skeletal muscle B604 1152.20 PKCq contributes to myotube formation by environment by inhibiting fibroblast function.C.S. Fry, J.D. regulating protein synthesis. J.S. Marino, T. Hinds, R.A. Lee, J.R. Jackson, T.J. Kirby, E.E. Dupont-Versteegden, J.J. Hoover, E. Ondrus, J.L. Onion, A. Dowling, T. McLoughlin, McCarthy and C.A. Peterson. Univ. of Kentucky. E.R. Sanchez and J.W. Hill. Univ. of Toledo. B589 1152.5 Monocarboxylate transporter expression at B605 1152.21 A gender comparison of electromyography the onset of skeletal muscle regeneration. D. Smith and T. during repetitive arm work with and without mental stress. A. Washington. Univ. of Arkansas. Crenshaw, M. Fahlstrom and E. Lyskov. Univ. of Gavle and B590 1152.6 Hormone-sensitive lipase knockout mice have Umeå Univ., Sweden. higher post-exercise insulin sensitivity despite accumulation of B606 1152.22 Muscle-specific deletion of p38a/b MAPK diacylglycerol. A.K. Serup, T. Alsted, J. Wojtaszewski and B. improves glucose tolerance and reduces body fat but impairs Kiens. Univ. of Copenhagen. exercise capacity. N.P. Greene, V.A. Lira, K.H. Chain, M. B591 1152.7 Rac1 is a novel regulator of stretch-induced Zhang, S.R. Hargett, S.R. Keller and Z. Yan. Univ. of Virginia. glucose uptake in muscle. L. Sylow, M. Kleinert, E.A. Richter B607 1152.23 Fiber type specific PGC-1a content and and T.E. Jensen. Univ. of Copenhagen. its relation to capillarization and mitochondrial content. G. B592 1152.8 The myosin converter region influences cross- Gouspillou, N. Sgarioto, B. Norris and R.T. Hepple. McGill bridge stiffness and muscle kinetics. D. Swank, B. Glasheen, Univ. S. Ramanath, Q. Wang, D. Sheppard and L. Riley. Rensselaer B608 1152.24 A novel mechanism for UCP1-independent Polytech Inst. thermogenesis. L. Rowland, N. Bal and M. Periasamy. The B593 1152.9 Satellite cell depletion negatively impacts Ohio State Univ. voluntary wheel running performance in mice. J.R. Jackson, B609 1152.25 Vitamin D modulation of diaphragm C.S. Fry, T.J. Kirby, J.D. Lee, C.S. Dean, J.H. Werker, J.J. muscle strength in mice. A.D. Ray, K.J. Pesonius and P.A. McCarthy, E.E. Dupont-Versteegden and C.A. Peterson. Hershberger. Univ. at Buffalo and Roswell Park Cancer Inst. Univ. of Kentucky. B610 1152.26 Resistance training and CLA/n-3 administration B594 1152.10 Effects of hydrogen ion and inorganic improve myofiber size and myogenic capacity in high-fat diet- phosphate on calcium sensitivity in rat slow muscle fibers.C.R. fed mice. S-R. Lee, E. Jo, A.V. Khamoui, B-S. Park, M.C. Nelson and R.H. Fitts. Marquette Univ. Zourdos, L.B. Panton, M.J. Ormsbee and J-S. Kim. Univ. of Memphis and Florida State Univ.
404 TUESDAY PHYSIOLOGY
B611 1152.27 Combined endothelial and skeletal myofiber B625 1153.12 Adiponectin expression in liver, omental fat, and VEGF gene deletion leads to capillary regression in adult peripheral circulation in morbidly obese patients undergoing mouse hind limb muscle. A.G. Sulaeman, H. Delavar, J. Fine, Roux-en-Y gastric bypass. P. Sarkaria, J. Alley , B. Andrew , P.D. Wagner and E.C. Breen. UCSD. J-M. Prot, S. Samy , L. Fitzgerald , M.L. Shuler and M. Ariza- B612 1152.28 Abnormal fiber type specification in Nieto. Cornell Univ., Guthrie Clin. and Guthrie Fndn. for Educ. dystroglycanopathy skeletal muscle. A.M. Beedle and G.A. and Res., Sayre, PA. Melick. Univ. of Georgia. B626 1153.13 Body-on-a-chip BOAC: a tool to elucidate B613 1152.29 Identification of the ATP sensitive potassium clinical observations that involve modulations of the “ethylation channel isolated from mammal and avian skeletal muscle. J. pathway in association with the expression of adipokines. M. Urincho-Castro, S. Manzo-Ávalos, E. Sánchez-Duarte, X. Ariza-Nieto, J.B. Alley, S.A. Samy, L. Fitzgerald and M.L. Trujillo, M. Huerta, A. Saavedra-Molina and R. Montoya- Shuler. Cornell Univ. and Guthrie Clin., Sayre, PA. Pérez. Univ. Michoacana de San Nicolás de Hidalgo and Univ. de Colima, Mexico. 1154. PANCREATIC HORMONES, DIABETES AND NOVEL INTERVENTIONS FOR THE TREATMENT 1153. OBESITY AND SATIETY OF OBESITY AND DIABETES
Poster Poster
Tue. 7:30 am—Boston Convention & Exhibition Center, Tue. 7:30 am—Boston Convention & Exhibition Center, Exhibit Halls A-B Exhibit Halls A-B
Presentation time: 12:45 pm-3:00 pm Presentation time: 12:45 pm-3:00 pm B614 1153.1 The effect of shifting food-intake period on rat B627 1154.1 Pancreatic ACE2 shedding is associated with body weight and plasma levels of glucose, leptin, melatonin, impaired glycemia in high fat diet-fed mice. K.H. Chhabra, cholesterol and triglyceride. M.O. Tanira, A. Al Qutiti and B. Al K.B. Pedersen, H. Xia, V. Shenoy, M.K. Raizada and E. Jahwari. Sultan Qaboos Univ., Oman. Lazartigues. LSU Hlth. Sci. Ctr., New Orleans and Univ. of B615 1153.2 Unique roles for 3 specific amino acids in the Florida. control of food intake. J. Jordi, T.A. Lutz and F. Verrey. Univ. of B628 1154.2 Improved satiety effect of leptin fusion proteins Zurich. with prolonged plasma half-life in mice. F. Bolze, V. Morath, B616 1153.3 Dietary sodium suppresses high-fat diet weight S. Schneider, S. Mocek, M. Schlapschy, A. Skerra and M. gain in C57BL/6J mice. N.A. Pearson, N.K. Littlejohn, M.L. Klingenspor. Tech Univ. Munich, Freising. Lutter and J.L. Grobe. Univ. of Iowa. B629 1154.3 Effects of Sertoli cells implantation on type 2 B617 1153.4 Impaired skeletal muscle metabolism in diabetes in nonhuman primates. B.C. Hansen, D. Cameron, obesity-prone rats on a high fat diet. T.D. Allerton, E. Bench R. Calafiore, G. Luca, E.H. Linden and C. Szekeres. Univ. of and S. Primeaux. LSU Hlth. Sci. Ctr., New Orleans. South Florida and Univ. of Perugia. B618 1153.5 Obesity-resistant rats demonstrate enhanced B630 1154.4 Chronic carbon monoxide treatment attenuates energy sensing and metabolism. T.D. Allerton and S.D. the development of obesity and remodels adipocytes in mice Primeaux. LSU Hlth. Sci. Ctr., New Orleans. fed a high fat diet. P.A. Hosick, A.A. Al Amoudi, M.V. Storm, B619 1153.6 Cardiovascular and metabolic regulation in M.U. Gousset, B.E. Pruett, W. Gray III, J. Stout and D.E. Stec. mice with neuron specific deletion of the leptin receptor.J.M. Univ. of Mississippi Med. Ctr. do Carmo, A.A. da Silva, B.R. Pace, M.T. Davis and J.E. Hall. B631 1154.5 The role of skeletal muscle tribbles 3 on Univ. of Mississippi Med. Ctr. endoplasmic reticulum stress- and high fat diet-induced insulin B620 1153.7 The relationship of muscle sympathetic nerve resistance. H-J. Koh, T. Toyoda, M.M. Jung, M-Y. Lee, M.F. activity to the sympathetically-mediated thermic effect of food Hirshman and L.J. Goodyear. Joslin Diabetes Ctr. Inc. T in young healthy subjects. L.J. Matzek, J. Miles, M. Jensen, J. B632 1154.6 Targeting diabetes with a novel small molecule Levine, M. Joyner and T. Curry. Mayo Clin. activator of sarco/endoplasmic reticulum Ca2+-ATPase. S. U B621 1153.8 Low salt intake is associated with maternal Kang, R. Dhal, K. Zsebo, D. Thomas, R. Cornea, R. Hajjar E obesity before and during pregnancy. M.S. Tresoldi, J.C. and D. Lebeche. Mount Sinai Sch. of Med., Rosalind Franklin Heimann and K.L. Lopes. Univ. of São Paulo Sch. of Med. Univ. of Med. and Sci., Celladon Corp., San Diego and Univ. of B622 1153.9 Total circulating levels of adiponectin versus Minnesota, Minneapolis. transcript abundance in omental fat following the MIQE B633 1154.7 ACE2 gene therapy decreases fibrosis in guidelines in a group of morbidly obese patients. A.Z. Mobula, the pancreas of high fat diet-fed mice. H. Chodavarapu, K. J. Alley, S. Samy, L. Fitzgerald and M. Ariza. Cornell Univ. Chhabra, V. Shenoy, M.K. Raizada, X. Yue and E. Lazartigues. and Guthrie Clin., Sayre, PA. LSU Hlth. Sci. Ctr., New Orleans and Univ. of Florida. B623 1153.10 Severe left ventricular dysfunction following B634 1154.8 Influence of fish oil on skeletal muscle short-term high fat feeding in a canine model. M. Nelson, J. mitochondrial energetics and lipid metabolites during high-fat Broussard, C. Kolka, I.A. Bediako, L.S. Szczepaniak and R. diet. I.R. Lanza, A. Blachnio-Zabielska, P. Zabielski, K.S. Bergman. Cedars-Sinai Med. Ctr. Nair, M. Jensen and N. Lebrasseur. Mayo Clin. B624 1153.11 Metabolic effects of polydextrose, lactitol and B635 1154.9 Angiogenesis inhibitor, Sunitinib significantly Bacteroides thetaiotaomicron in rats fed with high-fat diet. K-H. reduces adipose tissue mass in high fat diet-induced Herzig, K. Olli, M. Madetoja and K. Tiihonen. Univ. of Oulu, postmenopausal obese mice. J-W. Gu, K.L. Makey, E. DuPont Nutr. and Hlth., Kantvik and SBW/Toxis, Turku, Finland. Chinchar, C. Howie and L. Miele. Univ. of Mississippi Med. Ctr.
405 PHYSIOLOGY TUESDAY
B636 1154.10 Hypothalamic mTOR pathway mediates B652 1154.26 Diosgenin administration improved neuronal actions of insulin. K. Muta, D.A. Morgan and K. hyperglycemia through the activation of muscular glucose Rahmouni. Univ. of Iowa. metabolism. K. Sato, S. Fujita and M. Iemitsu. Ritsumeikan B637 1154.11 Transcytosis of insulin across microvascular Univ., Japan. endothelium. P.M. Azizi, C. Wang, S.M. Armstrong, A. Klip and W.L. Lee. Univ. of Toronto, The Hosp. for Sick Children and 1155. ALCOHOLIC AND NONALCOHOLIC FATTY St. Michael’s Hosp., Toronto. LIVER DISEASES B638 1154.12 Treatment with sulodexide restores compromised glucose tolerance in diet-induced obese mice. Poster B. Eskens, H. Vink and J. VanTeeffelen. Maastricht Univ., Netherlands. Tue. 7:30 am—Boston Convention & Exhibition Center, B639 1154.13 TRPV1 in the paraventricular nucleus of the Exhibit Halls A-B hypothalamus is involved in the regulation of systemic blood Presentation time: 12:45 pm-3:00 pm glucose levels. A. Zsombok, K. Miyata, J.D. O’Hare, T.L. Fourrier, A.M. Krantz and A.V. Derbenev. Tulane Univ. B653 1155.1 Steatosis response to curcumin in an obese B640 1154.14 TNFa–mediated hyperglycemia in obese mouse model. A. Nookala, T. Quinn, B. Herndon, A. Molteni, Zucker rats following orthopedic trauma. L. Xiang, P.N. L. Alba, J. Nachnani and D. Bulchandani. Univ. of Missouri- Mittwede, J.S. Clemmer, S. Lu and R.L. Hester. Univ. of Kansas City Sch. of Med. and Sumner Med. Gp., Gallatin, TN. Mississippi Med. Ctr. B654 1155.2 Metformin, aerobic exercise, and the B641 1154.15 Hepatocyte nuclear factor 1a stimulates the combination in the treatment of type 2 diabetes and NAFLD compensatory axis of the renin-angiotensin system in the in OLETF rats. M.A. Linden, G.M. Meers, J.A. Fletcher, pancreatic islet by specific induction of angiotensin-converting S. Siddique, M.H. Laughlin, F.W. Booth, J.A. Ibdah, J.P. enzyme 2. K.B. Pedersen, K. Chhabra and E. Lazartigues. Thyfault and R.S. Rector. Univ. of Missouri-Columbia and LSU Hlth. Sci. Ctr., New Orleans. Harry S. Truman Mem. Veterans Med. Ctr. B642 1154.16 Activation of CaMKKa stimulates skeletal B655 1155.3 Effects of high dose of methionine on plasma muscle glucose uptake in insulin-resistant mice. C.A. Witczak, oxidative stress and lipid profiles in rats treated with ethanol. J.M. Hinkley, J.L. Ferey, C.A.S. Smith, L.A.A. Gilliam and SY. Kim and H. Min. Hannam Univ., South Korea. J.J. Brault. East Carolina Univ. Brody Sch. of Med. B656 1155.4 The role of b1 adrenergic receptor in non- B643 1154.17 CaMKKa stimulates skeletal muscle glucose alcoholic fat liver disease development. G.W. Fernandes, C.P. uptake independent of increases in glucose transporter Marcelino, P.C. Brum, M. Passarelli, B.M.L. Bocco and M.O. expression. J.M. Hinkley and C.A. Witczak. East Carolina Ribeiro. Fed. Univ. of São Paulo, Presbyterian Univ. Mackenzie, Univ. Brody Sch. of Med. São Paulo and Sch. of Phys. Educ. and Sport and Fac. of Med. B644 1154.18 Multivalent GLP-1/Yhb for targeted therapy Sci., Univ. of São Paulo. and imaging of pancreatic b-cells. K. Ananthakrishnan, L.V. B657 1155.5 Protective effect ofHhedyotis diffusa on Penrod, N.J. Hart, C.S. Weber, M. Anderson, J. Vagner, S.W. lipopolysaccharide-induced liver damage. M-J. Kang and J-I. Limesand and R.M. Lynch. Univ. of Arizona. Kim. Changwon Natl. Univ. and Inje Univ., South Korea. B645 1154.19 Effects of the Momordica charantia in the alterations caused by administration of a high fat diet (HL) as 1156. GASTROINTESTINAL CANCER AND a model of non-alcoholic fatty liver disease. M.E.S.M. Santos, METASTASIS B.S.O. Lemos, K.B. Teixeira, L.N. Silva, G.A. Souza, F.C.H. Pinto, L.A.R. Lima and M.E.S.M. Santos. Fed. Univ. of São Poster João Del Rei, Brazil. B646 1154.20 Effect of prolonged, mild cold exposure Tue. 7:30 am—Boston Convention & Exhibition Center, on metabolic regulation in insulin resistant overweight and Exhibit Halls A-B obese men. M. Chondronikola, N.M. Hurren, G. Porter, P. Presentation time: 12:45 pm-3:00 pm Annamalai, E. Volpi, E. Borsheim and L. Sidossis. Univ. of Texas Med. Branch and Shriners Hosps. for Children. B658 1156.1 Protective role of selenium and adiponectin B647 1154.21 Type II diabetes increases myocardial deficiency in chronic inflammation induced colon cancer.A. mitochondrial DNA damage by altered mitochondrial Saxena, K. Kaur, E. Fletcher, B. Larsen, S. Hegde and R. topoisomerase function. J.G. Edwards, B. Piteo, D. Laurent, Fayad. Univ. of South Carolina. M. Mitry and S. Hicks. New York Med. Col. B659 1156.2 New experimental model of gastric B648 1154.22 Upregulation of p21 activates the intrinsic carcinogenesis in rats with the use of formaldehyde and apoptotic pathway in pancreatic b cells. A.M. Hernandez, E.S. hydrogen peroxide mixture. M. Senchukova, A.A. Stadnikov Colvin and P.T. Fueger. Indiana Univ. Sch. of Med. and D.A. Bokov. Orenburg State Med. Acad., Russia. B649 1154.23 Identifying novel plasma biomarkers of B660 1156.3 The appearance of the gastric submucosal pancreatic beta-cell function using acute and chronic models microvessels and the degree of gastric mucosal atrophy may of hyperglycemia. T.P.J. Solomon, K. Karstoft, S.H. Knudsen predict prognosis in gastric cancer patients. O. Tomchuk. and B.K. Pedersen. Rigshospitalet, Copenhagen. Orenburg State Med. Acad., Russia. B650 1154.24 Rapamycin induces diabetes mellitus only in B661 1156.4 Chronic gastric inflammation drives the male mice. U. Partap and S.J. Swoap. Williams Col. malignant transformation of bone marrow-derived mesenchymal B651 1154.25 Chronic rapamycin treatment confers partially stem cells. J. Donnelly, M. Engevik, C. Xiao, R.T. Worrell and reversible diabetes mellitus. C.E. Schindler and S.J. Swoap. Y. Zavros. Univ. of Cincinnati and Cincinnati Children’s Hosp. Williams Col. Med. Ctr.
406 TUESDAY PHYSIOLOGY
B662 1156.5 Effect of leptin on HCT-116 colon cancer cell 1158. GASTROINTESTINAL NUTRIENT SENSORS growth. S. Tanner and D.L. Osborne. Paul Foster Sch. of Med., Texas Tech Univ. Hlth Sci. Ctr., El Paso. Poster
Tue. 7:30 am—Boston Convention & Exhibition Center, 1157. GASTROINTESTINAL MOTILITY Exhibit Halls A-B
Poster Presentation time: 12:45 pm-3:00 pm
Tue. 7:30 am—Boston Convention & Exhibition Center, B674 1158.1 Presence of luminal acetate sensing and Exhibit Halls A-B absorption mechanisms in rat duodenum. I. Kaji, Y. Akiba and J.D. Kaunitz. UCLA Med. Sch., West Los Angeles VA Med. Ctr. Presentation time: 12:45 pm-3:00 pm and Brentwood Biomed. Res. Inst., Los Angeles. B663 1157.1 Resveratrol relaxes cholecystokinin- and KCl- B675 1158.2 Activation of gut calcium-sensing receptor by induced tension in guinea pig gallbladder strips by inhibiting peptide agonists promotes glucose tolerance in rats. T. Hira, M. extracellular Ca2+ entry. L.W. Kline and E. Karpinski. Univ. of Muramatsu, A. Mitsunaga, E. Sato, S. Nakajima, Y. Kitahara, Alberta. Y. Eto and H. Hara. Sch. of Agr., Hokkaido Univ. and Ajinomoto B664 1157.2 Do incisor and molar periodontal ligament Co. Inc., Kawasaki. mechanoreceptors stimulate antral motility to different B676 1158.3 High fat diet decreases glucose-dependent degrees? M. Lorber. Georgetown Univ. Sch. of Med. modulation of 5-HT responses in gastrointestinal vagal afferent B665 1157.3 Effects of fibrates on duodenal contractions. neurons. A.E. Troy and K.N. Browning. Penn State Col. of J.D. Peuler, D. Belisle and L.E. Phelps. Midwestern Univ., IK. Med. B666 1157.4 Brain-derived neurotrophic factor augments the contraction of intestinal longitudinal muscle strips induced 1159. GI AND LIVER STEM CELLS by carbachol. M. Alqudah, S. Mahavadi, K.M. Srinivasa and J. Grider. Virginia Commonwealth Univ. Poster B667 1157.5 Inhibitory neuromuscular transmission in the mouse distal colon is mediated by SK and calcium activated Tue. 7:30 am—Boston Convention & Exhibition Center, chloride channels. Y. Bhattarai and J. Galligan. Michigan Exhibit Halls A-B State Univ. Presentation time: 12:45 pm-3:00 pm B668 1157.6 Dopamine enhances gastric motility through D1 dopaminergic receptors on cholinergic neurons in the B677 1159.1 Disruption of Shp2 tyrosine phosphatase myenteric plexus of rats. J. Song, L. Zheng, J. Xu and J. Zhu. promotes Hes1/Stat3 complex in intestinal epithelia, Capital Med. Univ., Beijing. contributing to enhanced self-renewal capacity and impaired B669 1157.7 Detection of local serotonin release and differentiation in the crypt niche. Q. Gui, X. Zhang, L. Xu, H. clearance in the human small intestine using amperometry. M. Cheng and Y. Ke. Sch. of Med., Hangzhou, China. France, J. Galligan and G. Swain. Michigan State Univ. B670 1157.8 Evidence for swallowing reflexes evoked by 1160. GI HORMONES, PEPTIDES AND RECEPTORS acid and mechanical stimulation of the vagal afferent nerves innervating the larynx in anesthetized guinea pigs. T. Tsujimura Poster and B.J. Canning. Johns Hopkins Asthma and Allergy Ctr. Tue. 7:30 am—Boston Convention & Exhibition Center, B671 1157.9 Perinatal high fat diet dysregulates GABAergic Exhibit Halls A-B signaling to vagal efferent motoneurons regulating gastric motility. Z.K. Reagan and K.N. Browning. Penn State Col. of Presentation time: 12:45 pm-3:00 pm Med. B678 1160.1 Effects of different sweeteners on incretin B672 1157.10 Activation of both phasic and tonic GABA T A hormone secretion, gastric emptying, intragastric distribution receptors modulates vagal efferent outflow regulating gastric U and postprandial glycemia in healthy humans. R.M. Pereira, motor functions. Z.K. Reagan and K.N. Browning. Penn State M. Secaf and R.B. de Oliveira. Sch. of Med. of Ribeirão Preto, E Col. of Med. Univ. of São Paulo. B673 1157.11 A Cav1.2 Ca2+ channel mutation that reduces B679 1160.2 Regulation of glucose metabolism by intestinal smooth muscle contractility. M.E. Duffey, J.M. nesfatin-1. Z. Li, Y. Li and W. Zhang. Peking Univ. Hlth. Sci. Ctr. Helman, S.F. Gugino, J.A. Russell, G.C.L. Bett and R.L. B680 1160.3 CCK8 enhances anti-diabetic efficacy of Rasmusson. Univ. at Buffalo. GLP1. Y. Chen, M. Song, F. Liu, J. Lockwood, J. Alsina and C. Hammond. Eli Lilly and Co. B681 1160.4 Primary cilia regulate gastrin secretion in GLUTag cells. M. Saqui-Salces and J.L. Merchant. Univ. of Michigan. B682 1160.5 Role of Na-K-2Cl symporter in GABA-evoked excitation in rat enteric neurons. S. Liu, T. Ji, W. Ren, M-H. Qu, J-X. Zhu and J.D. Wood. Univ. of Wisconsin-La Crosse, Capital Med. Univ., Beijing and The Ohio State Univ.
407 PHYSIOLOGY TUESDAY
B683 1160.6 Preserved adiposity in the Fischer 344 rat 1162. MECHANISMS OF INTESTINAL NUTRIENT, devoid of gut microbiota. F.A. Duca, T.D. Swartz, Y. Sakar and WATER AND ELECTROLYTE TRANSPORT M. Covasa. INRA, UMR 1319 Micalis, Jouy-en-Josas, France and Col. of Osteo. Med., Western Univ. of Hlth. Sci. Poster B684 1160.7 Ghrelin and peptide YY increase with weight loss during a 12-month intervention to reduce dietary energy Tue. 7:30 am—Boston Convention & Exhibition Center, density in obese women. B.R. Hill, B.J. Rolls, L.S. Roe, M.J. Exhibit Halls A-B De Souza and N.I. Williams. Penn State. Presentation time: 12:45 pm-3:00 pm B685 1160.8 GLP-2 receptor is required for glucose homeostasis and energy balance. X. Shi, S. Wen, B. Chang, L. B695 1162.1 Roles of RSK1 in LPA5R-induced NHE3 Chan and X. Guan. Baylor Col. of Med. regulation. B.K. Yoo and C.C. Yun. Emory Univ. B696 1162.2 Intact colonic K+ secretion in KCNMB2 knockout 1161. LIVER PHYSIOLOGY AND PATHOPHYSIOLOGY mice. C.K. Larsen, H.A. Praetorius and J. Leipziger. Aarhus Univ., Denmark. B697 1162.3 GIP regulates Pept1 via Akt and EPAC signaling Poster pathways in intestinal epithelial cells. S. Coon, J. Schwartz Tue. 7:30 am—Boston Convention & Exhibition Center, and S. Singh. Boston Univ. and VA Boston Healthcare Syst. Exhibit Halls A-B B698 1162.4 Luminal acid-associated post-prandial epithelial hypoxia maintains the expression of iron absorptive Presentation time: 12:45 pm-3:00 pm DMT1 and Dcytb in rat duodenum. Y. Akiba, I. Kaji and J.D. B686 1161.1 Increased corticosterone levels contribute Kaunitz. UCLA Med. Sch., West Los Angeles VA Med. Ctr. and to glucose intolerance induced by the absence of melatonin. Brentwood Biomed. Res. Inst., Los Angeles. S.C. Rodrigues, L. Pantaleão, C. Lellis-Santos, K. Veras, F. B699 1162.5 Role of GLUT5 and ketohexokinase in fructose- Amaral, G. Anhê and S. Bordin. Univ. of São Paulo and Fac. induced, acute increases in intestinal active Ca transport. P. of Med. Sci., State Univ. of Campinas, Brazil. Tharabenjasin, V. Douard, N. Krishnamra, J. Zuo, R.J. B687 1161.2 Alleviative effect of andrographolide on alpha- Johnson and R.P. Ferraris. UMDNJ-New Jersey Med. Sch. naphthylisothiocyanate-induced cholestatic liver injury in rats. and Mahidol Univ., Thailand. T. Khamphaya, P. Piyachaturawat and J. Weerachayaphorn. B700 1162.6 Role of metabolism in fructose-induced GLUT5 Mahidol Univ. Fac. of Sci., Thailand. regulation. C.R. Patel, V.R. Douard and R. Ferraris. UMDNJ, B688 1161.3 Enhanced autophagic flux contributes collagen Newark. production in hepatic stellate cells involving TGFbeta1/Smad B701 1162.7 Mechanisms underlying modulation of pathway signaling. X-Z. Chen, W-M. Yao, G. Zhang, H-L. Ye, SLC26A3 activity by Lactobacillus acidophilus-secreted L. Chen and F-C. Zhang. People’s Hosp. of Guangxi Zhuang soluble factors. A. Borthakur, S. Priyamvada, A. Kumar, T. Autonomous Reg., China. Gujral, A.A. Natarajan, W.A. Alrefai and P.K. Dudeja. Univ. of B689 1161.4 Histidine decarboxylase regulates biliary Illinois at Chicago and Jesse Brown VA Med. Ctr. homeostasis via autocrine histamine signaling. H. Francis, L. B702 1162.8 Farnesoid X receptor activation inhibits colonic Hargrove, G. Alpini and F. Meng. Scott & White Healthcare, epithelial CFTR expression—a new target for antidiarrheal Central Texas Veterans Healthcare Syst. and Texas A&M Univ. therapy? M.S. Mroz, N. Keating, J.B.J. Ward, S. Amu, R. Hlth. Sci. Ctr. Col. of Med., Temple. Sarker, P.G. Fallon, M. Donowitz and S.J. Keely. Royal Col. B690 1161.5 Genome-wide combinatorial transcriptional of Surgeons in Ireland, Trinity Col. Dublin and Johns Hopkins regulatory dynamics during early onset of liver regeneration Univ. Sch. of Med. and chronic alcohol intake. B. Patra, L. Kuttippurathu, D. B703 1162.9 Leucine and methionine share a Na/K- Cook, J.B. Hoek and R. Vadigepalli. Thomas Jefferson Univ. dependent amino acid transporter in shrimp hepatopancreas. B691 1161.6 Hepatic steatosis and severe coagulopathy A. Duka and G.A. Ahearn. Univ. of North Florida. precede premature death in GCN2 null mice treated with B704 1162.10 The G protein-coupled bile acid receptor, asparaginase. G.J. Wilson, P. She, E.T. Mirek, R.C. Wek and TGR5, is expressed on colonic epithelial cells and regulates T.G. Anthony. Rutgers Univ. and Indiana Univ. Sch. of Med. ion transport. J.B.J. Ward, M.S. Mróz and S.J. Keely. Royal B692 1161.7 Cystathione-g-lyase deficiency protects Col. of Surgeons in Ireland. mice from galactosamine/LPS-induced acute liver failure. K. B705 1162.11 Regulation of human intestinal SLC26A3 Shirozu, K. Tokuda, E. Marutani, D. Lefer, R. Wang and F. expression by hepatocyte nuclear factors. A. Kumar, A. Ichinose. Massachusetts Gen. Hosp. and Harvard Med. Sch., Alakkam, A. Borthakur, A.N. Anbazhagan, S. Saksena, Charlestown, Emory Univ. Sch. of Med. and Lakehead Univ., R.K. Gill, J. Malakooti, W.A. Alrefai and P.K. Dudeja. Univ. of Canada. Illinois at Chicago and Jesse Brown VA Med. Ctr. B693 1161.8 Roux-en-Y gastric bypass surgery prevents diet-induced hepatic steatosis and endoplasmic reticulum stress in the liver of obese rats. J.D. Mosinski, M. Pagadala, H. Huang, O. Dan, H. Shimizu, E. Batayyah, P.R. Schauer, S.A. Brethauer and J.P. Kirwan. Cleveland Clin. Fndn. B694 1161.9 Characterization of the hepatic stellate cell populations in carbon tetrachloride liver rat through Golgi-Cox method. M.J. Gómez Villalobos, R. Giles, I. Carreon, S. Vidrio and V. Chagoya De Sanchez. Autonomous Univ. of Puebla, Mexico and UNAM, Mexico City.
408 TUESDAY PHYSIOLOGY
1163. MEMBRANE TRAFFICKING AND SECRETION IN B713 1165.3 Dexamethasone differentially modulates the DIGESTIVE EPITHELIA human angiotensinogen gene (hAGT) expression and blood pressure in transgenic mice containing -6A and -6G haplotype Poster of the hAGT gene. V.G. Pandey, S. Jain and A. Kumar. Univ. of Toledo. Tue. 7:30 am—Boston Convention & Exhibition Center, B714 1165.4 Changes in angiotensin II-induced vasomotor Exhibit Halls A-B function from newborn to senescence: correlation with Presentation time: 12:45 pm-3:00 pm expression of AT1 and AT2 receptors. Z. Vamos, P. Cseplo, Z. Bátai, O. Torok, I. Ivic, R. Matics, J. Hamar and A. Koller. B706 1163.1 Short duodenal acid exposure elicits protective Univ. of Pecs, Hungary. - HCO3 secretary response via Slc26a3, Slc26a9 and CFTR B715 1165.5 ACE2 activation ameliorates endothelial activation and NHE3 inhibition. U.E. Seidler, A.K. Singh, Y. Liu, function in the right ventricles of pulmonary hypertensive rats. B. Riederer, R. Engelhardt, B.K. Thakur and M. Soleimani. G.H. Sapp, J. Abbatematteo, C. Cole, V. Shenoy, M. Katovich, Hannover Med. Sch., Germany and Cincinnati Med. Sch. M. Raizada and J. Muller-Delp. Univ. of Florida. B707 1163.2 Involvement of store-operated cAMP signaling B716 1165.6 Increased ACE expression and iNOS protein in the regulation of colonic secretory function. J.M. Nichols, I. levels in the aorta of 2-month-old Syrian cardiomyopathic Maiellaro, J. Abi-Jaoude, S. Curci and A.M. Hofer. VA Boston hamsters. N. Cruz, J. Quidgley, L. El Musa, J. Garcia, G. Healthcare Syst./Harvard Med. Sch., West Roxbury. Torres, J. Miranda and M.J. Crespo. Univ. of Puerto Rico Sch. of Med. 1164. NEUROTRANSMISSION AND CA2+ B717 1165.7 Effects of chronic swim stress on endocrine SENSITIZATION IN GASTROINTESTINAL and cardiac function in angiotensin AT1a receptor knockout SMOOTH MUSCLES mice. N.K. Almahroug, A. Alhajoj, M. Alghamri, M. Morris and R.L. Pohlman. Wright State Univ. Poster B718 1165.8 Angiotensin II receptors modulate nitric oxide effects on renal sodium handling in conscious lambs. A.E. Tue. 7:30 am—Boston Convention & Exhibition Center, Vinturache and F.G. Smith. Univ. of Calgary, Canada. Exhibit Halls A-B B719 1165.9 Ang-(1-7) induced MAS1 receptor-mediated
Presentation time: 12:45 pm-3:00 pm angiogenesis in the rat microvasculature. B.R. Hoffmann, T.J. Stodola, J.R. Wagner and A.S. Greene. Med. Col. of B708 1164.1 NANC neuron mediated relaxation of murine Wisconsin. gastric fundus smooth muscle: phosphorylation of MYPT1 on B720 1165.10 Transgenic mice containing two haplotypes T696 (ROK site) and S695 (PKG site) are mutually exclusive. of human angiotensin receptor type 1 show differential gene G. Pfitzer, M.S. Hunger, S. Puetz, D. Metzler, L.T. Lubomirov expression and regulation of blood pressure. S. Jain, V.G. and A.V. Somlyo. Univ. of Cologne, Germany and Univ. of Pandey and A. Kumar. Univ. of Toledo. Virginia. B721 1165.11 Production of angiotensin within the SFO is B709 1164.2 Inhibition of RhoA/Rho kinase pathway and sufficient to increase ERK1/2 and CREB activity in the SFO contraction by endogenous and exogenous hydrogen sulfide and PVN. J. Coble, J. Grobe, M. Cassell and C.D. Sigmund. in gastrointestinal smooth muscle. A.D. Nalli, S. Rajagopal, Univ. of Iowa. S. Mahavadi, J.R. Grider and K.S. Murthy. Virginia B722 1165.12 Renin gene expression is regulated by Commonwealth Univ. chicken ovalbumin upstream promoter transcription factor B710 1164.3 Pharmacologically-induced alterations in II. P. Lachmann, S. Mayer, M. Roeser, S. Ishii, J.M. Suh, S. gastrointestinal motility affects regional colonic microbial Harlander, M. Desch, C. Brunssen, H. Morawietz, S.Y. Tsai, assemblage. K. Touw, Y. Wang, E. Huang, V. Leone and E. M-J. Tsai, B. Hohenstein, C. Hugo and V.T. Todorov. Univ. of Chang. Univ. of Chicago. Technol. Dresden, Univ. of Regensburg, Germany and Baylor T Col. of Med. 1165. RENIN-ANGIOTENSIN SYSTEM B723 1165.13 Human prorenin induces Ang II-independent U pressor response in neuron-specific human (pro)renin receptor E Poster transgenic mice. H. Peng, W. Li, C.D. Sigmund and Y. Feng. Tulane Univ. and Univ. of Iowa. Tue. 7:30 am—Boston Convention & Exhibition Center, B724 1165.14 Anti-hypertensive effect of chronic ICV Exhibit Halls A-B angiotensin-(1-7) in (mRen2)27 transgenic rats is blocked by Presentation time: 12:45 pm-3:00 pm Mas antagonist. L.M. Kangussu, R.A.S. Santos and M.J. Campagnole-Santos. Fed. Univ. of Minas Gerais, Brazil. B711 1165.1 The dissociation of the soluble prorenin B725 1165.15 Mineralocorticoid receptor antagonism exhibits receptor in plasma and urine of diabetic patients. D.Y. Arita, C. comparable BP lowering efficacy in Dahl salt-sensitive rats with Luffman, C.R.T. Bourgeois, T. Theti and M.C. Prieto. Tulane high versus low renin and aldosterone tone. X. Ma, L. Contino, Univ. and Fed. Univ. of Sao Paulo. O. Price, D. Shuster, L. Xu, J. Xue and J. Metzger. Merck Res. B712 1165.2 Effects of a (pro)renin receptor blocker on Lab., Rahway. NJ. weight gain in obese mice. P. Tan, Z. Shamansurova, C. B726 1165.16 Angiotensin II stimulates renin synthesis and Michel, T. Nguyen, P. Schiller, J. Gutkowska and J. Lavoie. secretion in mouse collecting duct M-1 cells via a PKC alpha- Univ. of Montreal, CRCHUM and IRCM. mediated cAMP stimulation mechanism. L. Liu, L.S. Lara, A.A. Gonzalez, C.R.T. Bourgeois, D.M. Seth and M.C. Prieto. Tulane Univ. Sch. of Med. and Fed. Univ. of Rio de Janeiro.
409 PHYSIOLOGY TUESDAY
B727 1165.17 Loss of cilia increases angiotensin II mediated B730 1165.20 Complementation of juxtaglomerular cell apical angiotensin-1-receptor localization in collecting duct granulation in ren-1d null mice by human renin. C. Buckley, cells. T. Saigusa, Y. Dang, T.A. Morinelli and P.D. Bell. Med. R. Nelson, M. Sharp, S. Flemming, C. Kenyon, L. Mullins, D. Univ. of South Carolina and VA Med. Ctr. Steppan and J. Mullins. Univ. of Edinburgh, Univ. of Dundee, B728 1165.18 Discovery of new renal ang II processing U.K. and Univ. of Regensburg, Germany. enzyme activity using mass spectrometry and gene deletion B731 1165.21 Markers of acute cardiovascular inflammation mouse models. N. Grobe, K.M. Elased, E.S.B. Salem, S.B. induced by angiotensin II in a murine model. A.B.C. Santana, Gurley, F.S. Ong, K.E. Bernstein, A.H. Schmaier and M. T. Souza-Oliveira, V. Barauna, L. Souza, M.C. Irigoyen, L. Morris. Wright State Univ., Duke Univ. and Durham VA Med. Campos, J.E. Krieger and S. Lacchini. Univ. of São Paulo. Ctrs., Cedars-Sinai Med. Ctr. and Univ. Hosps. Case Med. Ctr., B732 1165.22 Angiotensin II receptor signaling modulates Case Western Reserve Univ. vascular smooth muscle sensitivity to nitric oxide in an B729 1165.19 Phosphoproteomic analysis of signaling adiposity-specific manner in healthy adults. D.D. Christou, responses to angiotensin II in proximal tubules of NHE3- M-H. Hwang, A.E. Walker, M. Zigler and D.R. Seals. Univ. of deficient mice.X.C. Li, E. Miguel-Qin, G.E. Shull and J.L. Florida and Univ. of Colorado Boulder. Zhuo. Univ. of Mississippi Med. Ctr. and Univ. of Cincinnati Col. B733 1165.23 Acute mineralocorticoid receptor blockade of Med. leads to decreased vascular endothelial function in healthy older adults. H.K. Kim, M-H. Hwang, J-K. Yoo, M.J. Luttrell, T.H. Meade, M.W. English and D.D. Christou. Univ. of Florida and Texas A&M Univ. Hlth. Sci. Ctr.
Join Us Next Year! Experimental Biology 2014
April 26 – 30 San Deigo, CA
American Association of Anatomists (AAA) The American Physiological Society (APS) American Society for Biochemistry and Molecular Biology (ASBMB) American Society for Investigative Pathology (ASIP) American Society for Nutrition (ASN) American Society for Pharmacology and Experimental Therapeutics (ASPET)
For further information: www.experimentalbiology.org
410